[ { "uniprot_canonical_ac": "A0A8M1QHC1-1", "uniprot_id": "A0A8M1QHC1_DANRE", "mass": 131663.0, "length": 1163, "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "usp28", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 28 isoform X1", "refseq_ac": "XP_001920096", "gene_names_uniprotkb": "usp28", "gene_names_refseq": "usp28", "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 28 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:567050)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001920096.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QHC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RN59-1", "uniprot_id": "A0A8M1RN59_DANRE", "mass": 146011.0, "length": 1300, "protein_name": "Diacylglycerol kinase", "gene_name": "dgkzb", "organism": "Zebrafish", "refseq_name": "diacylglycerol kinase zeta isoform X1", "refseq_ac": "XP_003201445", "gene_names_uniprotkb": "dgkzb", "gene_names_refseq": "dgkzb", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase zeta isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100148835)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003201445.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0047649 alkylglycerol kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0046486 glycerolipid metabolic process;GO:0046339 diacylglycerol metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RN59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q0D8-1", "uniprot_id": "A0A2R8Q0D8_DANRE", "mass": 55268.0, "length": 483, "protein_name": "Platelet-derived growth factor subunit B", "gene_name": "pdgfbb", "organism": "Zebrafish", "refseq_name": "uncharacterized protein pdgfbb isoform X1", "refseq_ac": "XP_021329258", "gene_names_uniprotkb": "pdgfbb", "gene_names_refseq": "pdgfbb", "protein_names_uniprotkb": "Platelet-derived growth factor subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide", "protein_names_refseq": "uncharacterized protein pdgfbb isoform X1", "tax_id": 7955, "disease": "sinusitis (Disease Ontology:DOID:0050127); inflammatory bowel disease (Disease Ontology:DOID:0050589); basal ganglia calcification (Disease Ontology:DOID:0060230); COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); prostatic hypertrophy (Disease Ontology:DOID:11132); oligohydramnios (Disease Ontology:DOID:12215); leiomyoma (Disease Ontology:DOID:127); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); cholestasis (Disease Ontology:DOID:13580); Leydig cell tumor (Disease Ontology:DOID:2696); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); dermatofibrosarcoma protuberans (Disease Ontology:DOID:3507); choriocarcinoma (Disease Ontology:DOID:3594); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); familial meningioma (Disease Ontology:DOID:4586); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dre:796490); (R-DRE-114608); (R-DRE-1257604); (R-DRE-186763); (R-DRE-186797); (R-DRE-5673001); (R-DRE-6811558)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9PQH3", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005161 platelet-derived growth factor receptor binding", "go_cellular_component": "GO:0016020 membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051496 positive regulation of stress fiber assembly;GO:0035791 platelet-derived growth factor receptor-beta signaling pathway;GO:0051781 positive regulation of cell division;GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q0D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286YAF2-1", "uniprot_id": "A0A286YAF2_DANRE", "mass": 68468.0, "length": 601, "protein_name": "Grainyhead-like protein 1 homolog", "gene_name": "grhl1", "organism": "Zebrafish", "refseq_name": "grainyhead-like protein 1 homolog", "refseq_ac": "NP_001292496", "gene_names_uniprotkb": "grhl1; fc49a04; wu:fc49a04", "gene_names_refseq": "fc49a04; grhl1; wu:fc49a04", "protein_names_uniprotkb": "Grainyhead-like protein 1 homolog", "protein_names_refseq": "grainyhead-like 1; grainyhead-like protein 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:324942)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19757382;22931925;23943873;25896282;26469318;28886269;28945736;29242584;34570762;34962934", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01016844.1, SRR32588734.2653585.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Mar 19, 2015 this sequence version replaced XP_005158795.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that grhl1 is a novel common marker of all or most 'non-keratinocyte' epidermal progenitors, and that the sub-functionalisation of these cells is regulated by differential positive and negative effects of Foxi3 factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6C3", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008544 epidermis development;GO:0048839 inner ear development;GO:0002934 desmosome organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A286YAF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5J6-1", "uniprot_id": "A0A8M2B5J6_DANRE", "mass": 134057.0, "length": 1230, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "hipk2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "hipk2; cb1009; si:dkey-16j24.2; si:dkey-239k7.1; wu:fk56d12", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:557551); (R-DRE-3899300); (R-DRE-6804756); (R-DRE-8939243); (R-DRE-9022692)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "15520368;21199918;25159144;27189481;27935819;31199790;31888327;33901262;34666023", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;2.3.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0045634 regulation of melanocyte differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2B5J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PSS7-1", "uniprot_id": "A0A8M1PSS7_DANRE", "mass": 47939.0, "length": 433, "protein_name": "Receptor-interacting serine/threonine-protein kinase 3 isoform X1", "gene_name": "ripk3", "organism": "Zebrafish", "refseq_name": "receptor-interacting serine/threonine-protein kinase 3 isoform X1", "refseq_ac": "XP_001343827", "gene_names_uniprotkb": "ripk3", "gene_names_refseq": "ripk3", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 3 isoform X1", "protein_names_refseq": "receptor-interacting serine/threonine-protein kinase 3 isoform X1", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adult respiratory distress syndrome (Disease Ontology:DOID:11394)", "pathway": " (dre:100004555)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004706 JUN kinase kinase kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PSS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QI61-1", "uniprot_id": "A0A2R8QI61_DANRE", "mass": 20432.0, "length": 182, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "arl3a", "organism": "Zebrafish", "refseq_name": "ADP-ribosylation factor-like protein 3a isoform 1", "refseq_ac": "NP_001315350", "gene_names_uniprotkb": "arl3a; si:dkey-52k1.1; zgc:110197", "gene_names_refseq": "arl3a; si:dkey-52k1.1; zgc:110197", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3", "protein_names_refseq": "ADP-ribosylation factor-like 3a; ADP-ribosylation factor-like protein 3a isoform 1", "tax_id": 7955, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 83 (Disease Ontology:DOID:0112140)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588733.1304412.1, SRR32588732.25436218.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jun 16, 2016 this sequence version replaced XP_009305433.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3V9", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005813 centrosome;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A2R8QI61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IS36-1", "uniprot_id": "A0A0R4IS36_DANRE", "mass": 44385.0, "length": 397, "protein_name": "Endophilin-B1", "gene_name": "sh3glb1b", "organism": "Zebrafish", "refseq_name": "endophilin-B1b isoform X1", "refseq_ac": "XP_005163364", "gene_names_uniprotkb": "sh3glb1b; im:5777505; sh3glb1; wu:fa08f03; wu:fb13e12", "gene_names_refseq": "im:5777505; sh3glb1b; sh3glb1; wu:fa08f03; wu:fb13e12", "protein_names_uniprotkb": "Endophilin-B1; SH3 domain-containing GRB2-like protein B1", "protein_names_refseq": "endophilin-B1b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:334911)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16109975;16448862;26469318;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAQ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0R4IS36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4INT7-1", "uniprot_id": "A0A0R4INT7_DANRE", "mass": 40680.0, "length": 360, "protein_name": "Homer protein homolog 1", "gene_name": "homer1b", "organism": "Zebrafish", "refseq_name": "homer protein homolog 1b isoform 2", "refseq_ac": "NP_001313219", "gene_names_uniprotkb": "homer1b; homer1; zgc:100854; zgc:92844", "gene_names_refseq": "homer1b; homer1; zgc:100854; zgc:92844", "protein_names_uniprotkb": "Homer protein homolog 1", "protein_names_refseq": "homer homolog 1b; homer homolog 1; homer protein homolog 1b isoform 2; homer scaffolding protein 1b", "tax_id": 7955, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:436769); (R-DRE-6794361)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "23936160;24002024;27189481;28252024;29201571;32179471;33200539;35754711;35877057;36613611", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588726.5948031.1, SRR32588733.2817736.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On May 13, 2016 this sequence version replaced XP_005157352.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Results indicate that miR-3906 controls [Ca(2+)]i homeostasis in fast muscle through fine tuning homer-1b expression during differentiation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P2K2", "ec_number_list": "", "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:2001256 regulation of store-operated calcium entry;GO:0061061 muscle structure development;GO:0007216 G protein-coupled glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4INT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2KFP7-1", "uniprot_id": "A0A0G2KFP7_DANRE", "mass": 80257.0, "length": 749, "protein_name": "Metal regulatory transcription factor 1", "gene_name": "mtf1", "organism": "Zebrafish", "refseq_name": "metal regulatory transcription factor 1 isoform X1", "refseq_ac": "XP_021322285", "gene_names_uniprotkb": "mtf1; MTF-1", "gene_names_refseq": "MTF-1; mtf1", "protein_names_uniprotkb": "Metal regulatory transcription factor 1; MRE-binding transcription factor; Transcription factor MTF-1", "protein_names_refseq": "metal regulatory transcription factor 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals. Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A. Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9PM66", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010043 response to zinc ion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0046686 response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2KFP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2KHQ4-1", "uniprot_id": "A0A0G2KHQ4_DANRE", "mass": 21845.0, "length": 197, "protein_name": "Dual specificity protein phosphatase", "gene_name": "dusp26", "organism": "Zebrafish", "refseq_name": "dual specificity protein phosphatase 26", "refseq_ac": "XP_699429", "gene_names_uniprotkb": "dusp26", "gene_names_refseq": "dusp26", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 26", "tax_id": 7955, "disease": "", "pathway": " (dre:570815)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_699429.1. COMPLETENESS: full length., [RefSeq]; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate. Involved in the modulation of AMPK and MAPK1/2 signaling pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T6Z5", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007409 axonogenesis;GO:0010842 retina layer formation;GO:0048666 neuron development;GO:0043409 negative regulation of MAPK cascade;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2KHQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2KIZ8-1", "uniprot_id": "DNAI3_DANRE", "mass": 110941.0, "length": 968, "protein_name": "Dynein axonemal intermediate chain 3", "gene_name": "dnai3", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "dnai3; wdr63", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 3; WD repeat domain 63", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;29285825", "class_list": "", "function": "May be involved in the regulation of cilia function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036156 inner dynein arm", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003341 cilium movement;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2KIZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2KN81-1", "uniprot_id": "A0A0G2KN81_DANRE", "mass": 57847.0, "length": 511, "protein_name": "Serine/threonine-protein kinase receptor", "gene_name": "acvr2bb", "organism": "Zebrafish", "refseq_name": "activin receptor type-2B", "refseq_ac": "XP_002667626", "gene_names_uniprotkb": "acvr2bb", "gene_names_refseq": "acvr2bb", "protein_names_uniprotkb": "Serine/threonine-protein kinase receptor; 2.7.11.30", "protein_names_refseq": "activin receptor type-2B", "tax_id": 7955, "disease": "", "pathway": " (dre:100331938)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RN24", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0048185 activin binding;GO:0017002 activin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048179 activin receptor complex", "go_biological_process": "GO:0071363 cellular response to growth factor stimulus;GO:0032924 activin receptor signaling pathway;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2KN81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2KQA6-1", "uniprot_id": "A0A0G2KQA6_DANRE", "mass": 48579.0, "length": 420, "protein_name": "Septin", "gene_name": "septin4b", "organism": "Zebrafish", "refseq_name": "septin 4b", "refseq_ac": "NP_001315432", "gene_names_uniprotkb": "septin4b; sept4b", "gene_names_refseq": "sept4b; septin4b", "protein_names_uniprotkb": "Septin", "protein_names_refseq": "septin 4b", "tax_id": 7955, "disease": "", "pathway": " (dre:100003446)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17967425;27189481;36855298", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505380 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Jun 25, 2025 this sequence version replaced NP_001315432.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P4Z5", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2KQA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2L0Q2-1", "uniprot_id": "A0A0G2L0Q2_DANRE", "mass": 28394.0, "length": 242, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "hacd1", "organism": "Zebrafish", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1", "refseq_ac": "NP_001314793", "gene_names_uniprotkb": "hacd1; ptpla", "gene_names_refseq": "hacd1; ptpla", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; 4.2.1.134", "protein_names_refseq": "protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A; protein tyrosine phosphatase-like, member A; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1", "tax_id": 7955, "disease": "congenital myopathy (Disease Ontology:DOID:0081337)", "pathway": " (dre:553326); (R-DRE-75876)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12477932;21873635;34016526", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH591206.1, EL646435.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On May 27, 2016 this sequence version replaced XP_699783.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P9G1", "ec_number_list": "4.2.1.134", "go_molecular_function": "GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2L0Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0G2L2K4-1", "uniprot_id": "A0A0G2L2K4_DANRE", "mass": 45729.0, "length": 410, "protein_name": "5-hydroxytryptamine receptor 7", "gene_name": "htr7d", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 7", "refseq_ac": "XP_003199632", "gene_names_uniprotkb": "htr7d; htr7", "gene_names_refseq": "htr7", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 7; Serotonin receptor 7", "protein_names_refseq": "5-hydroxytryptamine receptor 7", "tax_id": 7955, "disease": "", "pathway": " (dre:100536080)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003199632.1. COMPLETENESS: full length., [RefSeq]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RIZ1", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2L2K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0N4SUG9-1", "uniprot_id": "A0A0N4SUG9_DANRE", "mass": 40563.0, "length": 355, "protein_name": "P2Y purinoceptor 1", "gene_name": "p2ry1", "organism": "Zebrafish", "refseq_name": "P2Y purinoceptor 1", "refseq_ac": "XP_001343355", "gene_names_uniprotkb": "p2ry1", "gene_names_refseq": "p2ry1", "protein_names_uniprotkb": "P2Y purinoceptor 1; Purinergic receptor", "protein_names_refseq": "P2Y purinoceptor 1", "tax_id": 7955, "disease": "impotence (Disease Ontology:DOID:1875)", "pathway": " (dre:100003922); (R-DRE-416476); (R-DRE-417957); (R-DRE-418592)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PV70", "ec_number_list": "", "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0031686 A1 adenosine receptor binding;GO:0045031 G protein-coupled ATP receptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090075 relaxation of muscle;GO:0030168 platelet activation;GO:0002250 adaptive immune response;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0N4SUG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IAP0-1", "uniprot_id": "A0A0R4IAP0_DANRE", "mass": 62824.0, "length": 560, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "edem2", "organism": "Zebrafish", "refseq_name": "ER degradation-enhancing alpha-mannosidase-like protein 2 precursor", "refseq_ac": "NP_001292543", "gene_names_uniprotkb": "edem2", "gene_names_refseq": "edem2", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "ER degradation-enhancing alpha-mannosidase-like protein 2 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:402801)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25253178;26469318;29778665;36768797", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009155.1, BC055547.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P1W0", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:1904380 endoplasmic reticulum mannose trimming;GO:1904154 positive regulation of retrograde protein transport, ER to cytosol;GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0R4IAP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IB00-1", "uniprot_id": "A0A0R4IB00_DANRE", "mass": 68960.0, "length": 613, "protein_name": "Matrix metalloproteinase-17b isoform 1 precursor", "gene_name": "mmp17b", "organism": "Zebrafish", "refseq_name": "matrix metalloproteinase-17b isoform 1 precursor", "refseq_ac": "NP_001352431", "gene_names_uniprotkb": "mmp17b; mmpl2; sb:eu434; si:ch211-199b20.1", "gene_names_refseq": "mmp17b; mmpl2; sb:eu434; si:ch211-199b20.1", "protein_names_uniprotkb": "Matrix metalloproteinase-17b isoform 1 precursor", "protein_names_refseq": "MMPLd; matrix metallopeptidase like 2; matrix metalloproteinase-17b isoform 1 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:100322027); (R-DRE-1592389); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "17439641;19929220;24098510;26908177;27189481;28837622;30405119;33554855;33951474;37426341", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588714.37648867.1, SRR32588733.1469454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Aug 30, 2018 this sequence version replaced XP_002664536.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Mmp17b is essential for proper neural crest cell migration in vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RRF6", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0001755 neural crest cell migration;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IB00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IBS8-1", "uniprot_id": "A0A0R4IBS8_DANRE", "mass": 54139.0, "length": 469, "protein_name": "Sorting nexin-7 isoform X1", "gene_name": "snx7", "organism": "Zebrafish", "refseq_name": "sorting nexin-7 isoform X1", "refseq_ac": "XP_005162901", "gene_names_uniprotkb": "snx7; zgc:92458", "gene_names_refseq": "snx7; zgc:92458", "protein_names_uniprotkb": "Sorting nexin-7 isoform X1", "protein_names_refseq": "sorting nexin-7 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:431776)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22213104;23897685;31680844", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B9U9", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0000407 phagophore assembly site;GO:0005737 cytoplasm", "go_biological_process": "GO:0001889 liver development;GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0000423 mitophagy;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IBS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PAA2-1", "uniprot_id": "A0A8M1PAA2_DANRE", "mass": 113498.0, "length": 1024, "protein_name": "Signal peptide, CUB and EGF-like domain-containing protein 1", "gene_name": "scube1", "organism": "Zebrafish", "refseq_name": "signal peptide, CUB and EGF-like domain-containing protein 1 isoform 1 precursor", "refseq_ac": "NP_001315528", "gene_names_uniprotkb": "scube1; im:7427863", "gene_names_refseq": "im:7427863; scube1", "protein_names_uniprotkb": "Signal peptide, CUB and EGF-like domain-containing protein 1; Signal peptide, CUB and EGF-like domain-containing protein 2", "protein_names_refseq": "signal peptide, CUB and EGF-like domain-containing protein 1 isoform 1 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:797832)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16109975;16626681;22609552;23271740;26469318;26699903;27189481;31053140;33788916", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JQ740109.1, GFIL01034633.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Jun 18, 2016 this sequence version replaced XP_009298451.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology., [UniProtKB, UniProtKB, UniProtKB]; Data show that knocking down the function of all three scube genes scube1, scube2 and scube3 simultaneously phenocopies a complete loss of Hedgehog (HH) signal transduction in the embryo., [RefSeq, PubMed]; Describe novel mechanisms in targeting S1 to the plasma membrane and demonstrate that N-glycans are required for S1 functions during primitive haematopoiesis in zebrafish., [RefSeq, PubMed]; Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005615 extracellular space", "go_biological_process": "GO:0030509 BMP signaling pathway;GO:0002040 sprouting angiogenesis;GO:0009967 positive regulation of signal transduction;GO:0007224 smoothened signaling pathway;GO:0060215 primitive hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1PAA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ICJ7-1", "uniprot_id": "A0A0R4ICJ7_DANRE", "mass": 40525.0, "length": 353, "protein_name": "Beta-1,4-galactosyltransferase", "gene_name": "b4galt4", "organism": "Zebrafish", "refseq_name": "beta-1,4-galactosyltransferase 4", "refseq_ac": "NP_001007402", "gene_names_uniprotkb": "b4galt4; CH1073-177A15.1; wu:fb08f09; zgc:101780", "gene_names_refseq": "CH1073-177A15.1; b4galt4; fk70b01; wu:fb08f09; wu:fk70b01; zgc:101780", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase; 2.4.1.-; Beta-1,4-GalTase", "protein_names_refseq": "beta-1,4-galactosyltransferase 4", "tax_id": 7955, "disease": "", "pathway": " (dre:492760); (R-DRE-2022854); (R-DRE-975577)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588720.145178.1, SRR32588714.15580721.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Oct 18, 2018 this sequence version replaced NP_001007402.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BA11", "ec_number_list": "2.4.1.-;2.4.1.90;2.4.1.274", "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003945 N-acetyllactosamine synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0R4ICJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IPT5-1", "uniprot_id": "A0A0R4IPT5_DANRE", "mass": 68133.0, "length": 618, "protein_name": "Lipolysis-stimulated lipoprotein receptor isoform X1", "gene_name": "lsr", "organism": "Zebrafish", "refseq_name": "lipolysis-stimulated lipoprotein receptor isoform X1", "refseq_ac": "XP_005157688", "gene_names_uniprotkb": "lsr; Lisch7; lsrl; zgc:114089", "gene_names_refseq": "Lisch7; lsrl; lsr; zgc:114089", "protein_names_uniprotkb": "Lipolysis-stimulated lipoprotein receptor isoform X1", "protein_names_refseq": "lipolysis-stimulated lipoprotein receptor isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B3Y8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0012505 endomembrane system;GO:0005886 plasma membrane;GO:0061689 tricellular tight junction", "go_biological_process": "GO:0031016 pancreas development;GO:0007492 endoderm development;GO:0060856 establishment of blood-brain barrier;GO:1904274 tricellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IPT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286Y8T8-1", "uniprot_id": "A0A286Y8T8_DANRE", "mass": 69426.0, "length": 640, "protein_name": "Numb-like protein", "gene_name": "numbl", "organism": "Zebrafish", "refseq_name": "numb-like protein isoform X1", "refseq_ac": "XP_005173435", "gene_names_uniprotkb": "numbl; z-numb; zgc:123031", "gene_names_refseq": "numbl; z-numb; zgc:123031", "protein_names_uniprotkb": "Numb-like protein", "protein_names_refseq": "numb-like protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:497616)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16493689;16701985;21179188;21937602;26392552;27189481;28642593;30833887", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in the process of neurogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BKQ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0007399 nervous system development;GO:0007368 determination of left/right symmetry;GO:0045746 negative regulation of Notch signaling pathway;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A286Y8T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IE73-1", "uniprot_id": "A0A0R4IE73_DANRE", "mass": 41546.0, "length": 374, "protein_name": "Dual specificity protein phosphatase", "gene_name": "dusp7", "organism": "Zebrafish", "refseq_name": "dual specificity protein phosphatase 7", "refseq_ac": "NP_956068", "gene_names_uniprotkb": "dusp7; fd19d04; wu:fd19d04; zgc:55957; zgc:77211", "gene_names_refseq": "dusp7; fd19d04; wu:fd19d04; zgc:55957; zgc:77211", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity phosphatase 6; dual specificity protein phosphatase 7", "tax_id": 7955, "disease": "", "pathway": " (dre:327246); (R-DRE-112409); (R-DRE-202670); (R-DRE-5675221)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "19445916;27189481;31787979", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC066600.1, SRR26395028.670763.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA4476743 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jan 29, 2016 this sequence version replaced NP_956068.2. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PEJ2", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;2.7.11.24;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IE73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IEQ0-1", "uniprot_id": "A0A0R4IEQ0_DANRE", "mass": 47017.0, "length": 400, "protein_name": "Guanine nucleotide-binding protein subunit alpha", "gene_name": "gna11a", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein subunit alpha-11a", "refseq_ac": "NP_001038501", "gene_names_uniprotkb": "gna11a; gna11; si:dkey-42p8.2", "gene_names_refseq": "gna11a; gna11; si:dkey-42p8.2", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha", "protein_names_refseq": "G11-2; Galpha 11b; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide-binding protein subunit alpha-11a", "tax_id": 7955, "disease": "familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108)", "pathway": " (dre:563953)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;19164534;20333216;21242316;21452212;25184495;28252024;34816109;35255436;35816398", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000022.1. On Sep 1, 2006 this sequence version replaced XP_692405.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N1YX09", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IEQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IES7-1", "uniprot_id": "BLTP1_DANRE", "mass": 545451.0, "length": 4923, "protein_name": "Bridge-like lipid transfer protein family member 1", "gene_name": "bltp1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "bltp1; si:ch211-233a24.2", "gene_names_refseq": "", "protein_names_uniprotkb": "Bridge-like lipid transfer protein family member 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;29290337", "class_list": "", "function": "Bridge-like lipid transfer protein that functions as molecular bridges between endoplasmic reticulum and the membranes targeted for lipid delivery (By similarity). Forms a tunnel with multiple beta-grooves that allows the transport of phospholipids (By similarity). Plays a role in endosomal trafficking and endosome recycling (By similarity). Also involved in the actin cytoskeleton and cilia structural dynamics (By similarity). Acts as a regulator of phagocytosis (By similarity). Required for the formation of endoplasmic reticulum-plasma membrane junctions which are critical for lipid exchange (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1904121 phosphatidylethanolamine transfer activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0098793 presynapse;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0006909 phagocytosis;GO:0016197 endosomal transport;GO:0032456 endocytic recycling;GO:0120009 intermembrane lipid transfer;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IES7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IF99-1", "uniprot_id": "ZD16B_DANRE", "mass": 44693.0, "length": 382, "protein_name": "Palmitoyltransferase ZDHHC16B", "gene_name": "zdhhc16b", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC16B", "refseq_ac": "NP_001314728", "gene_names_uniprotkb": "zdhhc16b; DHHC-16B; zgc:63934", "gene_names_refseq": "DHHC-16B; zdhhc16b; zgc:63934", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC16B; 2.3.1.225; DHHC-16B; Zinc finger DHHC domain-containing protein 16B", "protein_names_refseq": "palmitoyltransferase ZDHHC16B; probable palmitoyltransferase ZDHHC16; zinc finger DHHC domain-containing protein 16B; zinc finger DHHC-type containing 16b; zinc finger DHHC-type palmitoyltransferase 16b; zinc finger, DHHC domain containing 16b", "tax_id": 7955, "disease": "", "pathway": " (dre:393316)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.120516.1, SRR26395012.866180.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On May 26, 2016 this sequence version replaced XP_005156038.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Palmitoyl acyltransferase that mediates palmitoylation of proteins and is required during embryonic heart development. Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IX74;F1R4N0;R4GEX6", "ec_number_list": "2.3.1.225;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007507 heart development;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0R4IF99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IFJ4-1", "uniprot_id": "A0A0R4IFJ4_DANRE", "mass": 129868.0, "length": 1181, "protein_name": "Pyruvate carboxylase", "gene_name": "pcxa", "organism": "Zebrafish", "refseq_name": "pyruvate carboxylase a", "refseq_ac": "NP_001315285", "gene_names_uniprotkb": "pcxa; PYCa; pcl; zgc:123047", "gene_names_refseq": "PYCa; pcl; pcxa; zgc:123047", "protein_names_uniprotkb": "Pyruvate carboxylase; 6.4.1.1", "protein_names_refseq": "pyruvate carboxylase a; pyruvate carboxylase, like", "tax_id": 7955, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); pyruvate carboxylase deficiency disease (Disease Ontology:DOID:3651)", "pathway": " (dre:553283); (R-DRE-196780); (R-DRE-70263); (R-DRE-70268)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "19500364;24611545;25754827;27189481;32849832;39021799;39069827", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01029598.1, GDQH01000183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On Jun 25, 2025 this sequence version replaced NP_001315285.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments, and RNA-seq and orthologous data., [RefSeq]; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second., [UniProtKB, UniProtKB]; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3R3", "ec_number_list": "6.4.1.1;6.4.1.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004736 pyruvate carboxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0046959 habituation;GO:0006629 lipid metabolic process;GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0R4IFJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IGE7-1", "uniprot_id": "A0A0R4IGE7_DANRE", "mass": 50377.0, "length": 460, "protein_name": "Tumor necrosis factor receptor superfamily member EDAR precursor", "gene_name": "edar", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor receptor superfamily member EDAR precursor", "refseq_ac": "NP_001108536", "gene_names_uniprotkb": "edar; fls", "gene_names_refseq": "edar; fls", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member EDAR precursor", "protein_names_refseq": "ectodysplasin receptor; finless; tumor necrosis factor receptor superfamily member EDAR precursor", "tax_id": 7955, "disease": "ectodermal dysplasia 10A (Disease Ontology:DOID:0111663); ectodermal dysplasia 10B (Disease Ontology:DOID:0111665); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793)", "pathway": " (dre:796370); (R-DRE-5669034)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18833299;24173565;24821783;26134525;27504894;28835471;30014845;32398375;32647268;32703943", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588714.35892423.1, SRR32588728.21990920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898404, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 18, 2025 this sequence version replaced NP_001108536.2., [RefSeq]; Eda and edar are not required for early development but are specific for the development of adult skeletal and dental structures. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UYT0", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0007631 feeding behavior;GO:0060348 bone development;GO:0033333 fin development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IGE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IH97-1", "uniprot_id": "A0A0R4IH97_DANRE", "mass": 69195.0, "length": 631, "protein_name": "Aryl hydrocarbon receptor nuclear translocator-like protein 2", "gene_name": "bmal2", "organism": "Zebrafish", "refseq_name": "aryl hydrocarbon receptor nuclear translocator-like protein 2", "refseq_ac": "NP_571653", "gene_names_uniprotkb": "bmal2; arntl2; wu:fj90c09", "gene_names_refseq": "arntl2; bmal2; wu:fj90c09", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator-like protein 2", "protein_names_refseq": "aryl hydrocarbon receptor nuclear translocator-like 2; aryl hydrocarbon receptor nuclear translocator-like protein 2; bmal2a; brain and muscle ARNT-like 2", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:58099)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14653994;15657039;17785416;18602103;18850331;32186706;33508534;34769181;34925060;35512552", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128806.1, GDQH01023007.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jun 25, 2025 this sequence version replaced NP_571653.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBM1", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007623 circadian rhythm;GO:0009416 response to light stimulus;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IH97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IHZ4-1", "uniprot_id": "A0A0R4IHZ4_DANRE", "mass": 44973.0, "length": 400, "protein_name": "5-hydroxytryptamine receptor 7", "gene_name": "htr7c", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 7", "refseq_ac": "XP_002662019", "gene_names_uniprotkb": "htr7c", "gene_names_refseq": "htr7c", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 7; Serotonin receptor 7", "protein_names_refseq": "5-hydroxytryptamine receptor 7", "tax_id": 7955, "disease": "", "pathway": " (dre:572143)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_002662019.4. COMPLETENESS: full length., [RefSeq]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RQY0", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IHZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B533-1", "uniprot_id": "A0A8M2B533_DANRE", "mass": 92318.0, "length": 833, "protein_name": "dual-specificity kinase", "gene_name": "dyrk1b", "organism": "Zebrafish", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1", "refseq_ac": "XP_005158271", "gene_names_uniprotkb": "dyrk1b; si:ch211-225p5.1", "gene_names_refseq": "dyrk1b; si:ch211-225p5.1", "protein_names_uniprotkb": "dual-specificity kinase; 2.7.12.1", "protein_names_refseq": "dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); abdominal obesity-metabolic syndrome 3 (Disease Ontology:DOID:0060612); intellectual disability (Disease Ontology:DOID:1059); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (dre:556212)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20014342;26469318;27307198;28252024;34752933", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.10.2;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001706 endoderm formation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IJC7-1", "uniprot_id": "A0A0R4IJC7_DANRE", "mass": 79330.0, "length": 715, "protein_name": "ATP-dependent zinc metalloprotease YME1L1", "gene_name": "yme1l1b", "organism": "Zebrafish", "refseq_name": "ATP-dependent zinc metalloprotease YME1L1b", "refseq_ac": "NP_001317997", "gene_names_uniprotkb": "yme1l1b; ftsh1; yme1l1; zgc:162158", "gene_names_refseq": "ftsh1; yme1l1b; yme1l1; zgc:162158", "protein_names_uniprotkb": "ATP-dependent zinc metalloprotease YME1L1; ATP-dependent metalloprotease FtsH1; YME1-like protein 1", "protein_names_refseq": "ATP-dependent metalloprotease FtsH1; ATP-dependent zinc metalloprotease YME1L1b", "tax_id": 7955, "disease": "optic atrophy 11 (Disease Ontology:DOID:0111436)", "pathway": " (dre:557907); (R-DRE-8949664); (R-DRE-9840373)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10843804;26039894", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1717953.1, SRR26395014.1531560.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Sep 8, 2016 this sequence version replaced XP_009295158.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Characterization of the human YME1-like 1 ortholog., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P496", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0007005 mitochondrion organization;GO:0034982 mitochondrial protein processing;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IJC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IJV5-1", "uniprot_id": "A0A0R4IJV5_DANRE", "mass": 68512.0, "length": 608, "protein_name": "ATP-dependent RNA helicase", "gene_name": "ddx52", "organism": "Zebrafish", "refseq_name": "probable ATP-dependent RNA helicase DDX52", "refseq_ac": "NP_001037780", "gene_names_uniprotkb": "ddx52", "gene_names_refseq": "ddx52", "protein_names_uniprotkb": "ATP-dependent RNA helicase; 3.6.4.13", "protein_names_refseq": "probable ATP-dependent RNA helicase DDX52", "tax_id": 7955, "disease": "", "pathway": " (dre:407696)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27189481;34323273;34463754", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC085394.1, GDQH01019906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1, EH493950.1, EH580775.1, CT716534.2 and CT698434.2. On Aug 22, 2015 this sequence version replaced NP_001037780.1., [RefSeq]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N8X8", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0040008 regulation of growth;GO:0030490 maturation of SSU-rRNA;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IJV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IKC9-1", "uniprot_id": "A0A0R4IKC9_DANRE", "mass": 140702.0, "length": 1268, "protein_name": "Zinc finger protein basonuclin-2 isoform 1", "gene_name": "bnc2", "organism": "Zebrafish", "refseq_name": "zinc finger protein basonuclin-2 isoform 1", "refseq_ac": "NP_001314679", "gene_names_uniprotkb": "bnc2; bnp; coral; crl; fi18b05; poppy; si:dkey-114f6.1; wu:fi18b05", "gene_names_refseq": "bnc2; bnp; coral; crl; fi18b05; poppy; si:dkey-114f6.1; wu:fi18b05", "protein_names_uniprotkb": "Zinc finger protein basonuclin-2 isoform 1", "protein_names_refseq": "basonuclin 2; zinc finger protein basonuclin-2 isoform 1", "tax_id": 7955, "disease": "urinary tract obstruction (Disease Ontology:DOID:5200)", "pathway": " (dre:559327)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19956727;23737760;25374113;25558068;26469318;27189481;31051115;32629302", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.31419234.1, SRR32588719.14079853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476740, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jun 13, 2025 this sequence version replaced NP_001314679.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Bnc2 acts non-autonomously to the melanophore lineage and is expressed by hypodermal cells adjacent to chromatophores during adult pigment pattern formation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3N3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0048066 developmental pigmentation;GO:0039020 pronephric nephron tubule development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A0R4IKC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IKE0-1", "uniprot_id": "A0A0R4IKE0_DANRE", "mass": 63837.0, "length": 553, "protein_name": "Calsequestrin", "gene_name": "casq1a", "organism": "Zebrafish", "refseq_name": "calsequestrin-1a precursor", "refseq_ac": "NP_001003620", "gene_names_uniprotkb": "casq1a; bZ1G18.2; zgc:100957", "gene_names_refseq": "bZ1G18.2; casq1a; zgc:100957", "protein_names_uniprotkb": "Calsequestrin", "protein_names_refseq": "CSQ1; calsequestrin-1a precursor", "tax_id": 7955, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:445226)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19837881;20878432;21256971;26585961;27189481;30252882;31468037;32372920;35893052;39175772", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155741.1, SRR32588714.38944799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On May 22, 2009 this sequence version replaced NP_001003620.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle., [UniProtKB, UniProtKB, UniProtKB]; Three zebrafish Casqs: Casq1a, Casq1b and Casq2 were identified by mass spectrometry (Data are available via ProteomeXchange with identifier PXD002455). Skeletal and cardiac zebrafish calsequestrins share properties with mammalian Casq1 and Casq2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N1H2", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0030018 Z disc;GO:0033018 sarcoplasmic reticulum lumen", "go_biological_process": "GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IKE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IKF0-1", "uniprot_id": "A0A0R4IKF0_DANRE", "mass": 30140.0, "length": 257, "protein_name": "Apolipoprotein A-Ib precursor", "gene_name": "apoa1b", "organism": "Zebrafish", "refseq_name": "apolipoprotein A-Ib precursor", "refseq_ac": "NP_001093614", "gene_names_uniprotkb": "apoa1b; wu:fb66d03; wu:fd19c08; xx:sd49", "gene_names_refseq": "apoa1b; wu:fb66d03; wu:fd19c08; xx:sd49", "protein_names_uniprotkb": "Apolipoprotein A-Ib precursor", "protein_names_refseq": "apolipoprotein A-Ib precursor", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary hypoalphalipoproteinemia 2 (Disease Ontology:DOID:0080958); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); Budd-Chiari syndrome (Disease Ontology:DOID:11512); nephrotic syndrome (Disease Ontology:DOID:1184); familial hypercholesterolemia (Disease Ontology:DOID:13810); hypolipoproteinemia (Disease Ontology:DOID:1387); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); coronary artery disease (Disease Ontology:DOID:3393); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100101640)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16631158;24608635;24611545;25030662;25633982;34725363;36948605;37094155;38699158;39528516", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CK872615.1, EH492121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB855858.1 and CK024997.1. On Nov 22, 2012 this sequence version replaced NP_001093614.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NE64", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron;GO:0034362 low-density lipoprotein particle;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:0033344 cholesterol efflux;GO:0055090 acylglycerol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IKF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IKF7-1", "uniprot_id": "A0A0R4IKF7_DANRE", "mass": 63048.0, "length": 574, "protein_name": "Sulfite oxidase, mitochondrial", "gene_name": "suox", "organism": "Zebrafish", "refseq_name": "sulfite oxidase, mitochondrial", "refseq_ac": "NP_001313359", "gene_names_uniprotkb": "suox", "gene_names_refseq": "suox", "protein_names_uniprotkb": "Sulfite oxidase, mitochondrial; 1.8.3.1", "protein_names_refseq": "sulfite oxidase, mitochondrial", "tax_id": 7955, "disease": "isolated sulfite oxidase deficiency (Disease Ontology:DOID:0111270); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (dre:566675); (R-DRE-1614517)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "26469318;27189481;39159974;39778749", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.1375804.1, SRR26395039.956750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 26, 2025 this sequence version replaced NP_001313359.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7X9", "ec_number_list": "1.8.3.1", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0020037 heme binding;GO:0043546 molybdopterin cofactor binding;GO:0008482 sulfite oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0007399 nervous system development;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0R4IKF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IKQ6-1", "uniprot_id": "A0A0R4IKQ6_DANRE", "mass": 80425.0, "length": 719, "protein_name": "CD248 molecule, endosialin a precursor", "gene_name": "cd248a", "organism": "Zebrafish", "refseq_name": "CD248 molecule, endosialin a precursor", "refseq_ac": "NP_001092698", "gene_names_uniprotkb": "cd248a; fb96b12; wu:fb96b12; zgc:162651", "gene_names_refseq": "cd248a; fb96b12; wu:fb96b12; zgc:162651", "protein_names_uniprotkb": "CD248 molecule, endosialin a precursor", "protein_names_refseq": "CD248 molecule, endosialin a precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:323364)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28705894;35088848;36119065", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC141789.1, GDQQ01014874.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 10, 2025 this sequence version replaced NP_001092698.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Cd248a and Cd248b in zebrafish participate in innate immune responses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NDU1", "ec_number_list": "", "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016477 cell migration;GO:0032496 response to lipopolysaccharide;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IKQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IL29-1", "uniprot_id": "A0A0R4IL29_DANRE", "mass": 48288.0, "length": 417, "protein_name": "Calreticulin", "gene_name": "calr3b", "organism": "Zebrafish", "refseq_name": "calreticulin 3b precursor", "refseq_ac": "NP_958873", "gene_names_uniprotkb": "calr3b; calr3; calrl; id:ibd1087; wu:fc59g10", "gene_names_refseq": "calr3b; calr3; calrl; cb583; id:ibd1087; sb:cb583; wu:fc59g10", "protein_names_uniprotkb": "Calreticulin", "protein_names_refseq": "calreticulin 3b precursor; calreticulin like", "tax_id": 7955, "disease": "", "pathway": " (dre:321315)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23014190;23615277;24019943;27068748;27189481;27716741;29471808", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01002926.1, GDQQ01000357.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1, EH579061.1 and EH602296.1. On Jun 19, 2015 this sequence version replaced NP_958873.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PCH6", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0033018 sarcoplasmic reticulum lumen;GO:0060473 cortical granule", "go_biological_process": "GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0R4IL29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IL71-1", "uniprot_id": "A0A0R4IL71_DANRE", "mass": 115533.0, "length": 998, "protein_name": "Insulin-degrading enzyme", "gene_name": "ide", "organism": "Zebrafish", "refseq_name": "insulin-degrading enzyme isoform 1", "refseq_ac": "NP_001082994", "gene_names_uniprotkb": "ide; zgc:162603", "gene_names_refseq": "ide; zgc:162603", "protein_names_uniprotkb": "Insulin-degrading enzyme; 3.4.24.56; Insulin protease; Insulysin", "protein_names_refseq": "insulin-degrading enzyme isoform 1; insulysin", "tax_id": 7955, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:561390); (R-DRE-5689880); (R-DRE-77387)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18065431;24714733;26469318;26963759;27189481;30721868;31154177;33524730;35295584;36403304", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588715.3201522.1, SRR26395014.633251.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On or before Jun 24, 2024 this sequence version replaced XP_005169584.1, NP_001082994.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JI45", "ec_number_list": "3.4.24.56;3.1.1.29;3.4.19.12;3.6.5.-", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1990798 pancreas regeneration;GO:0050435 amyloid-beta metabolic process;GO:0042447 hormone catabolic process;GO:0043171 peptide catabolic process;GO:0031018 endocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IL71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ILA8-1", "uniprot_id": "A0A0R4ILA8_DANRE", "mass": 47883.0, "length": 427, "protein_name": "26S proteasome regulatory subunit 6A isoform X1", "gene_name": "psmc3", "organism": "Zebrafish", "refseq_name": "26S proteasome regulatory subunit 6A isoform X1", "refseq_ac": "XP_005169019", "gene_names_uniprotkb": "psmc3; wu:fb39a02; zgc:86713", "gene_names_refseq": "psmc3; wu:fb39a02; zgc:86713", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6A isoform X1", "protein_names_refseq": "26S proteasome regulatory subunit 6A isoform X1", "tax_id": 7955, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); cataract (Disease Ontology:DOID:83)", "pathway": " (R-DRE-1169091); (R-DRE-1234176); (R-DRE-1236978); (R-DRE-174084); (R-DRE-174154); (R-DRE-174178); (R-DRE-174184); (R-DRE-187577); (R-DRE-195253); (R-DRE-2467813); (R-DRE-349425); (R-DRE-350562); (R-DRE-382556); (R-DRE-450408); (R-DRE-4608870); (R-DRE-4641257); (R-DRE-4641258); (R-DRE-5358346); (R-DRE-5610780); (R-DRE-5610785); (R-DRE-5632684); (R-DRE-5658442); (R-DRE-5668541); (R-DRE-5687128); (R-DRE-5689603); (R-DRE-5689880); (R-DRE-6798695); (R-DRE-68867); (R-DRE-68949); (R-DRE-69017); (R-DRE-69481); (R-DRE-69601); (R-DRE-75815); (R-DRE-8852276); (R-DRE-8854050); (R-DRE-8939236); (R-DRE-8939902); (R-DRE-8941858); (R-DRE-8948751); (R-DRE-8951664); (R-DRE-9755511); (R-DRE-9762114); (R-DRE-9766229); (R-DRE-983168); (R-DRE-9907900); (R-DRE-9929491); (R-DRE-9932298); (R-DRE-9954709)", "pathway_count": 48, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BG93", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0002088 lens development in camera-type eye;GO:0060879 semicircular canal fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4ILA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ILY5-1", "uniprot_id": "A0A0R4ILY5_DANRE", "mass": 60072.0, "length": 532, "protein_name": "TNF receptor-associated factor", "gene_name": "traf2b", "organism": "Zebrafish", "refseq_name": "TNF receptor-associated factor 2 isoform X1", "refseq_ac": "XP_005165556", "gene_names_uniprotkb": "traf2b", "gene_names_refseq": "traf2b", "protein_names_uniprotkb": "TNF receptor-associated factor; 2.3.2.27", "protein_names_refseq": "TNF receptor-associated factor 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-3371378); (R-DRE-5218900); (R-DRE-5357786); (R-DRE-5357905); (R-DRE-5357956); (R-DRE-5668541); (R-DRE-5675482); (R-DRE-5676594); (R-DRE-5689880); (R-DRE-69416); (R-DRE-75893)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BD02", "ec_number_list": "3.4.19.12;2.3.2.27;2.7.11.10;2.7.11.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008289 lipid binding;GO:0061630 ubiquitin protein ligase activity;GO:0035591 signaling adaptor activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:1990604 IRE1-TRAF2-ASK1 complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043235 receptor complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0006915 apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0042981 regulation of apoptotic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4ILY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IM91-1", "uniprot_id": "A0A0R4IM91_DANRE", "mass": 105181.0, "length": 915, "protein_name": "Short transient receptor potential channel 4b isoform X1", "gene_name": "trpc4b", "organism": "Zebrafish", "refseq_name": "short transient receptor potential channel 4b isoform X1", "refseq_ac": "XP_009290061", "gene_names_uniprotkb": "trpc4b; trpc4a", "gene_names_refseq": "trpc4a; trpc4b", "protein_names_uniprotkb": "Short transient receptor potential channel 4b isoform X1", "protein_names_refseq": "short transient receptor potential channel 4b isoform X1", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (R-DRE-3295583)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AIN4", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005261 monoatomic cation channel activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0006812 monoatomic cation transport;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IM91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IMG2-1", "uniprot_id": "A0A0R4IMG2_DANRE", "mass": 57098.0, "length": 507, "protein_name": "N-acetylglucosamine-6-sulfatase", "gene_name": "gnsb", "organism": "Zebrafish", "refseq_name": "glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b precursor", "refseq_ac": "NP_956135", "gene_names_uniprotkb": "gnsb; gns; wu:fi20h10; zgc:55370", "gene_names_refseq": "gnsb; gns; wu:fi20h10; zgc:55370", "protein_names_uniprotkb": "N-acetylglucosamine-6-sulfatase; 3.1.6.14; Glucosamine-6-sulfatase", "protein_names_refseq": "glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b precursor", "tax_id": 7955, "disease": "mucopolysaccharidosis type IIID (Disease Ontology:DOID:0111402); mucopolysaccharidosis III (Disease Ontology:DOID:12801)", "pathway": " (dre:327635)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11116086;16109975;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045323.1, GDQH01000390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On or before Feb 25, 2016 this sequence version replaced XP_005155531.1, NP_956135.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments and orthologous alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PFZ3", "ec_number_list": "", "go_molecular_function": "GO:0008449 N-acetylglucosamine-6-sulfatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0030203 glycosaminoglycan metabolic process;GO:0030200 heparan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4IMG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IMZ7-1", "uniprot_id": "A0A0R4IMZ7_DANRE", "mass": 36050.0, "length": 315, "protein_name": "[histone H4]-lysine(20) N-methyltransferase", "gene_name": "kmt5ab", "organism": "Zebrafish", "refseq_name": "lysine methyltransferase 5Ab", "refseq_ac": "NP_001093559", "gene_names_uniprotkb": "kmt5ab; setd8b; wu:fc23f12; zgc:171649", "gene_names_refseq": "kmt5ab; setd8b; wu:fc23f12; zgc:171649", "protein_names_uniprotkb": "[histone H4]-lysine(20) N-methyltransferase; 2.1.1.361", "protein_names_refseq": "SET domain containing (lysine methyltransferase) 8b; SET domain containing 8b; lysine methyltransferase 5Ab", "tax_id": 7955, "disease": "", "pathway": " (dre:100004770)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18231586;24174574;24240475;26972483;31078877;36846912", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC151909.1, GDQH01026878.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001093559.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NFD5", "ec_number_list": "2.1.1.361;2.1.1.-;2.1.1.354;2.1.1.362;2.1.1.364;2.1.1.359;2.1.1.355", "go_molecular_function": "GO:0042799 histone H4K20 methyltransferase activity;GO:0140944 histone H4K20 monomethyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005700 polytene chromosome", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0R4IMZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IN78-1", "uniprot_id": "A0A0R4IN78_DANRE", "mass": 48024.0, "length": 432, "protein_name": "Serine/threonine-protein kinase 24", "gene_name": "stk24b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase 24 isoform X1", "refseq_ac": "XP_005165890", "gene_names_uniprotkb": "stk24b; stk24; wu:fi29b08; zgc:66137", "gene_names_refseq": "stk24b; stk24; wu:fi29b08; zgc:66137", "protein_names_uniprotkb": "Serine/threonine-protein kinase 24; 2.7.11.1; Mammalian STE20-like protein kinase 3; STE20-like kinase MST3", "protein_names_refseq": "serine/threonine-protein kinase 24 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-111465); (R-DRE-75153)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BD45", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0048679 regulation of axon regeneration;GO:0007507 heart development;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IN78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4INB9-1", "uniprot_id": "CX111_DANRE", "mass": 10226.0, "length": 94, "protein_name": "C-X-C motif chemokine 11-1", "gene_name": "cxcl11.1", "organism": "Zebrafish", "refseq_name": "C-X-C motif chemokine 11-1 precursor", "refseq_ac": "NP_001373708", "gene_names_uniprotkb": "cxcl11.1; cxcl11aa; cxcl11l", "gene_names_refseq": "cxcl11.1; cxcl11l", "protein_names_uniprotkb": "C-X-C motif chemokine 11-1", "protein_names_refseq": "C-X-C motif chemokine 11-1 precursor; C-X-C motif chemokine 11-1; CXCL-chr5d; CXCL11aa; chemokine (C-X-C motif) ligand 11 like; dr-chr5-CXCL11; vig7", "tax_id": 7955, "disease": "pulmonary sarcoidosis (Disease Ontology:DOID:13406); interstitial cystitis (Disease Ontology:DOID:13949); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (dre:798892)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16365434;17371995;18482437;22705555;23145839;23594743;25573892;33208372;33238180;33761328;35079792;36120339", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EB953258.1, SRR32588725.13374052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Sep 3, 2020 this sequence version replaced XP_001339307.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ligand for cxcr3.2. Chemotactic for macrophages., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006952 defense response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A0A0R4INB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4INZ3-1", "uniprot_id": "A0A0R4INZ3_DANRE", "mass": 53804.0, "length": 494, "protein_name": "Solute carrier family 41 member", "gene_name": "slc41a2a", "organism": "Zebrafish", "refseq_name": "solute carrier family 41 member 2", "refseq_ac": "XP_693342", "gene_names_uniprotkb": "slc41a2a", "gene_names_refseq": "slc41a2a", "protein_names_uniprotkb": "Solute carrier family 41 member", "protein_names_refseq": "solute carrier family 41 member 2", "tax_id": 7955, "disease": "", "pathway": " (dre:564932)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_693342.3. COMPLETENESS: full length., [RefSeq]; Acts as a magnesium transporter., [UniProtKB, UniProtKB]; Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TBE2", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030001 metal ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4INZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IP11-1", "uniprot_id": "ORA4_DANRE", "mass": 37804.0, "length": 344, "protein_name": "Olfactory receptor class A-like protein 4", "gene_name": "ora4", "organism": "Zebrafish", "refseq_name": "olfactory receptor class A-like protein 4", "refseq_ac": "NP_001410742", "gene_names_uniprotkb": "ora4", "gene_names_refseq": "ora4", "protein_names_uniprotkb": "Olfactory receptor class A-like protein 4", "protein_names_refseq": "olfactory receptor class A (V1r-like homolog); olfactory receptor class A-like protein 4", "tax_id": 7955, "disease": "", "pathway": " (dre:100004842)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17717047;22038944;23594743;26108469;26555542;32636305;36045218", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.21302788.1, SRR32588730.11163957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476815, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1 and AM778166.1. On Aug 16, 2023 this sequence version replaced XP_005168339.1., [RefSeq]; Probable olfactory receptor., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8E0X0;F6P1D8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0R4IP11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IP53-1", "uniprot_id": "A0A0R4IP53_DANRE", "mass": 115258.0, "length": 1001, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "taok1b", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase TAO1-B", "refseq_ac": "XP_009293944", "gene_names_uniprotkb": "taok1b", "gene_names_refseq": "taok1b", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase TAO1-B", "tax_id": 7955, "disease": "", "pathway": " (dre:554108); (R-DRE-141430); (R-DRE-141444); (R-DRE-2467813); (R-DRE-2500257); (R-DRE-5663220)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AU74", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;3.1.3.16;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;3.6.4.12;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0046330 positive regulation of JNK cascade;GO:0051493 regulation of cytoskeleton organization;GO:0032874 positive regulation of stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IP53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IPR8-1", "uniprot_id": "A0A0R4IPR8_DANRE", "mass": 83501.0, "length": 761, "protein_name": "ARF GTPase-activating protein GIT1 isoform X1", "gene_name": "git1", "organism": "Zebrafish", "refseq_name": "ARF GTPase-activating protein GIT1 isoform X1", "refseq_ac": "XP_697386", "gene_names_uniprotkb": "git1", "gene_names_refseq": "git1", "protein_names_uniprotkb": "ARF GTPase-activating protein GIT1 isoform X1", "protein_names_refseq": "ARF GTPase-activating protein GIT1 isoform X1", "tax_id": 7955, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dre:568935); (R-DRE-3928664); (R-DRE-9013148); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013406); (R-DRE-9013420); (R-DRE-9013423); (R-DRE-9013424)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_697386.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UVA0", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse;GO:0043005 neuron projection;GO:0098793 presynapse", "go_biological_process": "GO:0001525 angiogenesis;GO:0007420 brain development;GO:0001568 blood vessel development;GO:0036465 synaptic vesicle recycling;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IPR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IPV5-1", "uniprot_id": "A0A0R4IPV5_DANRE", "mass": 56634.0, "length": 509, "protein_name": "Protein disulfide-isomerase", "gene_name": "p4hb", "organism": "Zebrafish", "refseq_name": "protein disulfide-isomerase precursor", "refseq_ac": "NP_998529", "gene_names_uniprotkb": "p4hb; psmb3; zgc:92596", "gene_names_refseq": "p4hb; psmb3; zgc:92596", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1", "protein_names_refseq": "procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide; protein disulfide-isomerase precursor", "tax_id": 7955, "disease": "Cole-Carpenter syndrome (Disease Ontology:DOID:0060438)", "pathway": " (dre:406673); (R-DRE-1650814); (R-DRE-264876); (R-DRE-3299685); (R-DRE-381426); (R-DRE-5358346); (R-DRE-8957275); (R-DRE-8964041); (R-DRE-9020591)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "16109975;23427857;23798569;26657776;30359749;31680844;32467236;36283702", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4ISX6;A0A8M1PGX7", "ec_number_list": "5.3.4.1;3.4.24.81;1.8.3.2;3.1.1.98;3.4.21.112;1.11.1.9;3.1.-.-", "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A0R4IPV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IQM9-1", "uniprot_id": "A0A0R4IQM9_DANRE", "mass": 68715.0, "length": 603, "protein_name": "Syntaxin-binding protein 1", "gene_name": "stxbp1a", "organism": "Zebrafish", "refseq_name": "syntaxin-binding protein 1a isoform X1", "refseq_ac": "XP_005161170", "gene_names_uniprotkb": "stxbp1a; fj43h10; stxbp1; wu:fj36d12; wu:fj43h10; zgc:114171", "gene_names_refseq": "fj43h10; stxbp1a; stxbp1; wu:fj36d12; wu:fj43h10; zgc:114171", "protein_names_uniprotkb": "Syntaxin-binding protein 1; Protein unc-18 homolog 1; Protein unc-18 homolog A", "protein_names_refseq": "syntaxin-binding protein 1a isoform X1", "tax_id": 7955, "disease": "West syndrome (Disease Ontology:DOID:0050562); developmental and epileptic encephalopathy 4 (Disease Ontology:DOID:0080436)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B819", "ec_number_list": "", "go_molecular_function": "GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0098793 presynapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0099525 presynaptic dense core vesicle exocytosis;GO:1903305 regulation of regulated secretory pathway;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IQM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IR18-1", "uniprot_id": "A0A0R4IR18_DANRE", "mass": 64132.0, "length": 564, "protein_name": "Activating signal cointegrator 1", "gene_name": "trip4", "organism": "Zebrafish", "refseq_name": "activating signal cointegrator 1", "refseq_ac": "NP_001071043", "gene_names_uniprotkb": "trip4; dZ221I3.1; im:7143009; si:busm1-221i3.1; si:dkey-173l11.4; zgc:153348", "gene_names_refseq": "dZ221I3.1; im:7143009; si:busm1-221i3.1; si:dkey-173l11.4; trip4; zgc:153348", "protein_names_uniprotkb": "Activating signal cointegrator 1; Thyroid receptor-interacting protein 4", "protein_names_refseq": "activating signal cointegrator 1", "tax_id": 7955, "disease": "", "pathway": " (dre:568585)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26924529;33771997", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC124323.1, GDQH01022788.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA3505393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Aug 19, 2009 this sequence version replaced NP_001071043.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7UYD4", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0180022 RQC-trigger complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0061055 myotome development;GO:0006351 DNA-templated transcription;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IR18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IR92-1", "uniprot_id": "A0A0R4IR92_DANRE", "mass": 42661.0, "length": 380, "protein_name": "Dopamine receptor D4a", "gene_name": "drd4a", "organism": "Zebrafish", "refseq_name": "dopamine receptor D4a", "refseq_ac": "NP_001012634", "gene_names_uniprotkb": "drd4a; zgc:158147", "gene_names_refseq": "drd4a; zgc:158147", "protein_names_uniprotkb": "Dopamine receptor D4a", "protein_names_refseq": "dopamine D4a receptor; dopamine receptor D4a", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); pervasive developmental disorder (Disease Ontology:DOID:0060040); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); antisocial personality disorder (Disease Ontology:DOID:10939); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); opioid abuse (Disease Ontology:DOID:11206); pathological gambling (Disease Ontology:DOID:12399); conduct disorder (Disease Ontology:DOID:12995); alcohol use disorder (Disease Ontology:DOID:1574); substance abuse (Disease Ontology:DOID:302); dyslexia (Disease Ontology:DOID:4428); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); cannabis abuse (Disease Ontology:DOID:9505); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:503564)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16764679;22207143;22313674;23707737;26674873;35710785;35905303;36936688;39145297;39199302", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129139.1, AY750152.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC129139.1 and JBMGRA010000025.1. On Dec 4, 2015 this sequence version replaced NP_001012634.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N4C0", "ec_number_list": "", "go_molecular_function": "GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0021520 spinal cord motor neuron cell fate specification;GO:0014059 regulation of dopamine secretion;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IR92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IS45-1", "uniprot_id": "A0A0R4IS45_DANRE", "mass": 73435.0, "length": 654, "protein_name": "Conserved oligomeric Golgi complex subunit 6", "gene_name": "cog6", "organism": "Zebrafish", "refseq_name": "conserved oligomeric Golgi complex subunit 6", "refseq_ac": "NP_001307276", "gene_names_uniprotkb": "cog6; si:ch211-203f4.1; zgc:56117", "gene_names_refseq": "cog6; si:ch211-203f4.1; zgc:56117", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 6; COG complex subunit 6; Component of oligomeric Golgi complex 6", "protein_names_refseq": "conserved oligomeric Golgi complex subunit 6", "tax_id": 7955, "disease": "congenital disorder of glycosylation type IIl (Disease Ontology:DOID:0070264)", "pathway": " (dre:393290); (R-DRE-6807878); (R-DRE-6811438)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "27189481;30905685", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01021752.1, GDQH01008234.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH587218.1, JBMGRA010000015.1 and EH587636.1. On Feb 20, 2016 this sequence version replaced XP_005157440.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Required for normal Golgi function., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P2Y8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IS45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ISJ3-1", "uniprot_id": "A0A0R4ISJ3_DANRE", "mass": 109254.0, "length": 952, "protein_name": "5'-3' exoribonuclease", "gene_name": "xrn2", "organism": "Zebrafish", "refseq_name": "5'-3' exoribonuclease 2", "refseq_ac": "NP_001001944", "gene_names_uniprotkb": "xrn2; wu:fb38g12; wu:fj53d06; zgc:55717", "gene_names_refseq": "wu:fb38g12; wu:fj53d06; xrn2; zgc:55717", "protein_names_uniprotkb": "5'-3' exoribonuclease; 3.1.13.-", "protein_names_refseq": "5'-3' exoribonuclease 2", "tax_id": 7955, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung cancer (Disease Ontology:DOID:1324); leiomyosarcoma (Disease Ontology:DOID:1967)", "pathway": " (dre:321940)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21468032;27189481;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.1014815.1, SRR26395012.1333037.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Jul 22, 2010 this sequence version replaced NP_001001944.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1MZQ7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0004534 5'-3' RNA exonuclease activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006353 DNA-templated transcription termination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4ISJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ISQ3-1", "uniprot_id": "A0A0R4ISQ3_DANRE", "mass": 59103.0, "length": 525, "protein_name": "Neuronal acetylcholine receptor subunit beta-4 isoform X1", "gene_name": "chrnb4", "organism": "Zebrafish", "refseq_name": "neuronal acetylcholine receptor subunit beta-4 isoform X1", "refseq_ac": "XP_696993", "gene_names_uniprotkb": "chrnb4", "gene_names_refseq": "chrnb4", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-4 isoform X1", "protein_names_refseq": "neuronal acetylcholine receptor subunit beta-4 isoform X1", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); cocaine abuse (Disease Ontology:DOID:809); oral cavity cancer (Disease Ontology:DOID:8618)", "pathway": " (R-DRE-629594); (R-DRE-629597); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_696993.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TBN6", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0060084 synaptic transmission involved in micturition;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4ISQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IT36-1", "uniprot_id": "A0A0R4IT36_DANRE", "mass": 85744.0, "length": 791, "protein_name": "Junctophilin", "gene_name": "jph3b", "organism": "Zebrafish", "refseq_name": "junctophilin-3", "refseq_ac": "NP_001116174", "gene_names_uniprotkb": "jph3b; fc26e06; jph3; si:ch211-255l14.9; wu:fc26e06", "gene_names_refseq": "fc26e06; jph3b; jph3; si:ch211-255l14.9; wu:fc26e06", "protein_names_uniprotkb": "Junctophilin", "protein_names_refseq": "junctophilin 3; junctophilin-3", "tax_id": 7955, "disease": "Huntington's disease-like 2 (Disease Ontology:DOID:0090104)", "pathway": " (dre:569861)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21873635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.23297900.1, SRR26395062.1122086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000025.1. On Jun 5, 2025 this sequence version replaced NP_001116174.1., [RefSeq]; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NGP7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030314 junctional membrane complex", "go_biological_process": "GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0R4IT36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IT47-1", "uniprot_id": "A0A0R4IT47_DANRE", "mass": 22511.0, "length": 198, "protein_name": "Metalloproteinase inhibitor 4", "gene_name": "timp4.3", "organism": "Zebrafish", "refseq_name": "metalloproteinase inhibitor 4.3 precursor", "refseq_ac": "NP_001313362", "gene_names_uniprotkb": "timp4.3; timp4a; timp4", "gene_names_refseq": "timp4.3; timp4a; timp4", "protein_names_uniprotkb": "Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4", "protein_names_refseq": "TIMP metallopeptidase inhibitor 4a; TIMP2d; metalloproteinase inhibitor 4.3 precursor", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); renal hypertension (Disease Ontology:DOID:1073); endometrial cancer (Disease Ontology:DOID:1380); nephroblastoma (Disease Ontology:DOID:2154); endometrial carcinoma (Disease Ontology:DOID:2871); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:100124610)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17439641;19929220;25239370;27189481;27516442;30824836;31816958", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093210.1, EH472853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH447003.1 and EH479172.1. On May 18, 2016 this sequence version replaced XP_009303999.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P3B3", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A0R4IT47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ITR4-1", "uniprot_id": "A0A0R4ITR4_DANRE", "mass": 60009.0, "length": 523, "protein_name": "GPI mannosyltransferase 2", "gene_name": "pigv", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC18-A", "refseq_ac": "NP_001186989", "gene_names_uniprotkb": "pigv; zdhhc18a", "gene_names_refseq": "pigv; zdhhc18a", "protein_names_uniprotkb": "GPI mannosyltransferase 2; 2.4.1.-", "protein_names_refseq": "GPI mannosyltransferase 2; palmitoyltransferase ZDHHC18-A; zinc finger DHHC domain-containing protein 18-A", "tax_id": 7955, "disease": "hyperphosphatasia with impaired intellectual development syndrome 1 (Disease Ontology:DOID:0070433)", "pathway": " (dre:100148642); (R-DRE-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12477932;21873635", "class_list": "", "function": "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NWM6", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0000009 alpha-1,6-mannosyltransferase activity;GO:0004376 GPI mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4ITR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4ITS3-1", "uniprot_id": "A0A0R4ITS3_DANRE", "mass": 40955.0, "length": 372, "protein_name": "Trophoblast glycoprotein a precursor", "gene_name": "tpbg1b", "organism": "Zebrafish", "refseq_name": "trophoblast glycoprotein a precursor", "refseq_ac": "NP_919373", "gene_names_uniprotkb": "tpbg1b; YF-296; sb:cb613; tpbga; tpbgl; waif1a; zgc:109764", "gene_names_refseq": "YF-296; sb:cb613; tpbg1b; tpbga; tpbgl; waif1a; zgc:109764", "protein_names_uniprotkb": "Trophoblast glycoprotein a precursor", "protein_names_refseq": "Wnt-activated inhibitory factor 1a; trophoblast glycoprotein a precursor; trophoblast glycoprotein a; trophoblast glycoprotein-like", "tax_id": 7955, "disease": "", "pathway": " (dre:373095)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12045154;12641569;22100263;27189481;32243887", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JN653073.1, AB097825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Dec 16, 2016 this sequence version replaced NP_919373.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PET6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0060028 convergent extension involved in axis elongation;GO:2000052 positive regulation of non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0R4ITS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IU63-1", "uniprot_id": "A0A0R4IU63_DANRE", "mass": 130295.0, "length": 1158, "protein_name": "Metabotropic glutamate receptor 5", "gene_name": "grm1b", "organism": "Zebrafish", "refseq_name": "metabotropic glutamate receptor 1b", "refseq_ac": "NP_001289181", "gene_names_uniprotkb": "grm1b; grm1a; grm1; si:ch211-278p9.5", "gene_names_refseq": "grm1a; grm1b; grm1; si:ch211-278p9.5", "protein_names_uniprotkb": "Metabotropic glutamate receptor 5", "protein_names_refseq": "glutamate receptor, metabotropic 1; metabotropic glutamate receptor 1b", "tax_id": 7955, "disease": "autosomal recessive spinocerebellar ataxia 13 (Disease Ontology:DOID:0080062); spinocerebellar ataxia 44 (Disease Ontology:DOID:0080286); temporal lobe epilepsy (Disease Ontology:DOID:3328); uveal melanoma (Disease Ontology:DOID:6039); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (dre:100150246)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19500364;22523578;23047810;27189481;28252024;29551974;32004591;32045791;34566559;35665761", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01012009.1, SRR32588721.3014633.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Jun 25, 2025 this sequence version replaced NP_001289181.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B261", "ec_number_list": "", "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0030296 protein tyrosine kinase activator activity;GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:1902533 positive regulation of intracellular signal transduction;GO:0007216 G protein-coupled glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IU63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IUU4-1", "uniprot_id": "A0A0R4IUU4_DANRE", "mass": 20952.0, "length": 185, "protein_name": "NEDD8-conjugating enzyme UBC12", "gene_name": "ube2m", "organism": "Zebrafish", "refseq_name": "NEDD8-conjugating enzyme Ubc12", "refseq_ac": "XP_001920670", "gene_names_uniprotkb": "ube2m; si:ch1073-205c8.3", "gene_names_refseq": "si:ch1073-205c8.3", "protein_names_uniprotkb": "NEDD8-conjugating enzyme UBC12; 2.3.2.34; NEDD8 carrier protein; NEDD8-conjugating enzyme Ubc12; Ubiquitin-conjugating enzyme E2 M", "protein_names_refseq": "NEDD8-conjugating enzyme Ubc12", "tax_id": 7955, "disease": "", "pathway": " (dre:564377); (R-DRE-2173789); (R-DRE-8951664); (R-DRE-983168)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001920670.2. COMPLETENESS: full length., [RefSeq]; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QUV9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25;6.2.1.64", "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IUU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IVC8-1", "uniprot_id": "A0A0R4IVC8_DANRE", "mass": 15516.0, "length": 138, "protein_name": "Cytochrome c oxidase subunit 5A, mitochondrial", "gene_name": "cox5ab", "organism": "Zebrafish", "refseq_name": "cytochrome c oxidase subunit 5Ab", "refseq_ac": "NP_001292506", "gene_names_uniprotkb": "cox5ab; Cox5a2; cb01f09; cox5a; mg:cb01f09", "gene_names_refseq": "Cox5a2; cb01f09; cox5ab; cox5a; mg:cb01f09", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase polypeptide Va", "protein_names_refseq": "cytochrome c oxidase subunit 5Ab; cytochrome c oxidase subunit Vab; cytochrome c oxidase subunit Va", "tax_id": 7955, "disease": "mitochondrial complex IV deficiency nuclear type 20 (Disease Ontology:DOID:0070505)", "pathway": " (dre:326962)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16109975;17761683;20233836;22465854;27924917;30082823;30428046;32806454;32947675;33482547", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH546885.1, EH577566.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476756 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1, EH546885.1, EH437300.1 and EH483108.1. On Mar 19, 2015 this sequence version replaced XP_700576.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of developmental pathology due to cytochrome c oxidase deficiency, [RefSeq, PubMed]; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7E4", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0021522 spinal cord motor neuron differentiation;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IVC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IVH6-1", "uniprot_id": "A0A0R4IVH6_DANRE", "mass": 73775.0, "length": 646, "protein_name": "2.4.2.30; Protein mono-ADP-ribosyltransferase TIPARP", "gene_name": "tiparp", "organism": "Zebrafish", "refseq_name": "protein mono-ADP-ribosyltransferase TIPARP", "refseq_ac": "NP_001038484", "gene_names_uniprotkb": "tiparp; fc03g05; sb:cb841; si:dkey-33k14.4; wu:fc03g05; zgc:153056", "gene_names_refseq": "fc03g05; sb:cb841; si:dkey-33k14.4; tiparp; wu:fc03g05; zgc:153056", "protein_names_uniprotkb": "2.4.2.30; Protein mono-ADP-ribosyltransferase TIPARP", "protein_names_refseq": "protein mono-ADP-ribosyltransferase TIPARP", "tax_id": 7955, "disease": "", "pathway": " (dre:563506)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19874812;25556858;26469318;27189481;35145080;37709752", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH433035.1, EE316647.1, EE311950.1, CA472479.1, EB973772.1, EB882039.1, EH459039.1 and AI601719.1. On or before May 7, 2009 this sequence version replaced NP_001038901.1, XP_691960.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N9V5;A0AC58HTS7", "ec_number_list": "", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0008270 zinc ion binding;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0071466 cellular response to xenobiotic stimulus;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0R4IVH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IVI8-1", "uniprot_id": "A0A0R4IVI8_DANRE", "mass": 41240.0, "length": 377, "protein_name": "Homeobox even-skipped homolog protein 1", "gene_name": "evx1", "organism": "Zebrafish", "refseq_name": "homeobox even-skipped homolog protein 1", "refseq_ac": "NP_571324", "gene_names_uniprotkb": "evx1; cb416; evx-1", "gene_names_refseq": "cb416; evx-1; evx1", "protein_names_uniprotkb": "Homeobox even-skipped homolog protein 1", "protein_names_refseq": "homeobox even-skipped homolog protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:30499)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10668983;12622731;12880634;14519685;14579383;33334861;35675784;37352572;37746310;38017520", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01014407.1, GDQH01029718.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476732, SAMEA4476743 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1, EH589447.1, EH606917.1 and AA495010.1. On or before Jun 7, 2016 this sequence version replaced XP_005159566.1, NP_571324.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBM6;A0AC58HX75", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0072498 embryonic skeletal joint development;GO:0021521 ventral spinal cord interneuron specification;GO:0033334 fin morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IVI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IVK2-1", "uniprot_id": "A0A0R4IVK2_DANRE", "mass": 58576.0, "length": 523, "protein_name": "Frizzled-4", "gene_name": "fzd4", "organism": "Zebrafish", "refseq_name": "frizzled-4 precursor", "refseq_ac": "NP_001292398", "gene_names_uniprotkb": "fzd4; fz1; zg01", "gene_names_refseq": "fz1; fzd4; zg01", "protein_names_uniprotkb": "Frizzled-4", "protein_names_refseq": "frizzled homolog 1; frizzled homolog 4; frizzled-4 precursor", "tax_id": 7955, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); Norrie disease (Disease Ontology:DOID:0060844); exudative vitreoretinopathy 1 (Disease Ontology:DOID:0111412); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:30363)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21911385;23349976;23764775;26818140;32134197;32668265;33481775;35501893;38696577;8626800", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.1162722.1, SRR26395013.1235945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Mar 18, 2015 this sequence version replaced XP_005173482.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P6U6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001895 retina homeostasis;GO:0061298 retina vasculature development in camera-type eye;GO:0060070 canonical Wnt signaling pathway;GO:0061299 retina vasculature morphogenesis in camera-type eye;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IVK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IVU1-1", "uniprot_id": "A0A0R4IVU1_DANRE", "mass": 17512.0, "length": 157, "protein_name": "Transcription factor MafK isoform X1", "gene_name": "mafk", "organism": "Zebrafish", "refseq_name": "transcription factor MafK isoform X1", "refseq_ac": "XP_005164260", "gene_names_uniprotkb": "mafk", "gene_names_refseq": "mafk", "protein_names_uniprotkb": "Transcription factor MafK isoform X1", "protein_names_refseq": "transcription factor MafK isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:415133); (R-DRE-9707616); (R-DRE-9708530); (R-DRE-983231)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "15207702;15654768;24652768;27189481;31193955;36143473", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BBH9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0R4IVU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IWG9-1", "uniprot_id": "GCNA_DANRE", "mass": 65421.0, "length": 586, "protein_name": "Germ cell nuclear acidic protein", "gene_name": "gcna", "organism": "Zebrafish", "refseq_name": "germ cell nuclear acidic protein isoform X1", "refseq_ac": "XP_021336691", "gene_names_uniprotkb": "gcna; acrc; zgc:113346", "gene_names_refseq": "acrc; gcna; zgc:113346", "protein_names_uniprotkb": "Germ cell nuclear acidic protein; Acidic repeat-containing protein; Germ cell nuclear acidic peptidase", "protein_names_refseq": "germ cell nuclear acidic protein isoform X1", "tax_id": 7955, "disease": "X-linked spermatogenic failure 4 (Disease Ontology:DOID:0070595)", "pathway": " (dre:541448)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31839537", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May play a role in DNA-protein cross-links (DPCs) clearance, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body;GO:0005694 chromosome", "go_biological_process": "GO:0051983 regulation of chromosome segregation;GO:0106300 protein-DNA covalent cross-linking repair;GO:0140014 mitotic nuclear division;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IWG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IWL6-1", "uniprot_id": "A0A0R4IWL6_DANRE", "mass": 123089.0, "length": 1152, "protein_name": "Pumilio homolog 1", "gene_name": "pum1", "organism": "Zebrafish", "refseq_name": "pumilio homolog 1", "refseq_ac": "NP_001264048", "gene_names_uniprotkb": "pum1; fb96a03; pumilio1; si:ch211-285e16.1; wu:fb96a03; wu:fb96a08; zgc:63671", "gene_names_refseq": "fb96a03; pum1; pumilio1; si:ch211-285e16.1; wu:fb96a03; wu:fb96a08; zgc:63671", "protein_names_uniprotkb": "Pumilio homolog 1", "protein_names_refseq": "pumilio homolog 1 pseudogene; pumilio homolog 1", "tax_id": 7955, "disease": "cerebellar ataxia type 47 (Disease Ontology:DOID:0111743)", "pathway": " (dre:394176)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24062337;28381614;30103945;30289101;33148609;35588359", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: AB841266.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC055197.1 and AB841266.1. On Nov 20, 2014 this sequence version replaced NP_001264060.1., [RefSeq]; Pum1 phosphorylation in the early period of oocyte maturation is one of the key processes for promoting the disassembly of cyclin B1 RNA granules and translational activation of target mRNA., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NZX5", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006417 regulation of translation;GO:0043488 regulation of mRNA stability;GO:0035196 miRNA processing;GO:0019094 pole plasm mRNA localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0R4IWL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IXG2-1", "uniprot_id": "A0A0R4IXG2_DANRE", "mass": 82755.0, "length": 723, "protein_name": "Amyloid beta precursor like protein 1 isoform X1", "gene_name": "aplp1", "organism": "Zebrafish", "refseq_name": "amyloid beta precursor like protein 1 isoform X1", "refseq_ac": "XP_001342921", "gene_names_uniprotkb": "aplp1", "gene_names_refseq": "aplp1", "protein_names_uniprotkb": "Amyloid beta precursor like protein 1 isoform X1", "protein_names_refseq": "amyloid beta precursor like protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:404233)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001342921.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PZM7", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0046914 transition metal ion binding;GO:0031694 alpha-2A adrenergic receptor binding;GO:0031696 alpha-2C adrenergic receptor binding;GO:0031695 alpha-2B adrenergic receptor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IXG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IY89-1", "uniprot_id": "A0A0R4IY89_DANRE", "mass": 30799.0, "length": 278, "protein_name": "Homeobox protein Nkx-6.2", "gene_name": "nkx6.2", "organism": "Zebrafish", "refseq_name": "homeobox protein Nkx-6.2", "refseq_ac": "NP_001129256", "gene_names_uniprotkb": "nkx6.2", "gene_names_refseq": "nkx6.2", "protein_names_uniprotkb": "Homeobox protein Nkx-6.2", "protein_names_refseq": "NK6 transcription factor related, locus 2; homeobox protein Nkx-6.2", "tax_id": 7955, "disease": "spastic ataxia 8 (Disease Ontology:DOID:0080252)", "pathway": " (dre:565782)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17307034;17376808;17994542;18062957;18499750;31375626;32867764;33449448;34473348;35060900", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.10043658.1, SRR32588725.15264684.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1 and EH578673.1. On Oct 11, 2008 this sequence version replaced XP_694144.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Study shows that zebrafish primary motoneurons express two related transcription factors Nkx6.1 and Nkx6.2; in their absence, the CaP motoneuron subtype develops normally, whereas the MiP motoneuron subtype develops a interneuron-like morphology., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NLG5", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0021522 spinal cord motor neuron differentiation;GO:0031018 endocrine pancreas development;GO:0003309 type B pancreatic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0R4IY89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IZE6-1", "uniprot_id": "A0A0R4IZE6_DANRE", "mass": 38040.0, "length": 338, "protein_name": "D-aspartate oxidase", "gene_name": "ddo", "organism": "Zebrafish", "refseq_name": "D-aspartate oxidase precursor", "refseq_ac": "NP_001274017", "gene_names_uniprotkb": "ddo; zgc:172341", "gene_names_refseq": "ddo; zgc:172341", "protein_names_uniprotkb": "D-aspartate oxidase; 1.4.3.1", "protein_names_refseq": "D-aspartate oxidase precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:565385); (R-DRE-389661)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "27189481;34481069;35295584", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01046314.1, GDQH01008552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Nov 26, 2013 this sequence version replaced XP_002665184.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P573", "ec_number_list": "1.4.3.1", "go_molecular_function": "GO:0008445 D-aspartate oxidase activity;GO:0071949 FAD binding", "go_cellular_component": "GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0019478 D-amino acid catabolic process;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0R4IZE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IZL6-1", "uniprot_id": "A0A0R4IZL6_DANRE", "mass": 44228.0, "length": 392, "protein_name": "Ras-related GTP-binding protein", "gene_name": "rragcb", "organism": "Zebrafish", "refseq_name": "Ras-related GTP binding Cb", "refseq_ac": "NP_001093538", "gene_names_uniprotkb": "rragcb; si:dkey-218f9.9", "gene_names_refseq": "rragcb; si:dkey-218f9.9", "protein_names_uniprotkb": "Ras-related GTP-binding protein", "protein_names_refseq": "Ras-related GTP binding Cb", "tax_id": 7955, "disease": "", "pathway": " (dre:100000325)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30402654;37767930", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01034078.1, GDQQ01027158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505387, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On Jul 26, 2007 this sequence version replaced XP_001336060.1., [RefSeq]; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NE38", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046982 protein heterodimerization activity;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010507 negative regulation of autophagy;GO:0009267 cellular response to starvation;GO:0034198 cellular response to amino acid starvation;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0R4IZL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4IZR5-1", "uniprot_id": "A0A0R4IZR5_DANRE", "mass": 146551.0, "length": 1276, "protein_name": "Cohesin subunit SA", "gene_name": "stag2b", "organism": "Zebrafish", "refseq_name": "cohesin subunit SA-2 isoform X1", "refseq_ac": "XP_021328465", "gene_names_uniprotkb": "stag2b", "gene_names_refseq": "stag2b", "protein_names_uniprotkb": "Cohesin subunit SA; SCC3 homolog; Stromal antigen", "protein_names_refseq": "cohesin subunit SA-2 isoform X1", "tax_id": 7955, "disease": "Holoprosencephaly 13, X-linked (Disease Ontology:DOID:0060954); Mullegama-Klein-Martinez syndrome (Disease Ontology:DOID:0111845)", "pathway": " (dre:560751); (R-DRE-2467813); (R-DRE-2468052); (R-DRE-2470946); (R-DRE-2500257); (R-DRE-3108214)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9Q574", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0008278 cohesin complex", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007062 sister chromatid cohesion;GO:2001212 regulation of vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4IZR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0R4J755-1", "uniprot_id": "A0A0R4J755_DANRE", "mass": 56694.0, "length": 499, "protein_name": "Tyrosine-protein kinase", "gene_name": "hck", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase HCK", "refseq_ac": "XP_005174178", "gene_names_uniprotkb": "hck", "gene_names_refseq": "hck", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase HCK", "tax_id": 7955, "disease": "", "pathway": " (dre:101885596); (R-DRE-912631); (R-DRE-9705462)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BLR4", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2;2.7.1.153;2.7.1.137", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0R4J755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A140LG23-1", "uniprot_id": "A0A140LG23_DANRE", "mass": 15403.0, "length": 136, "protein_name": "Histone H3", "gene_name": "hist2h3ca1", "organism": "Zebrafish", "refseq_name": "histone 2, H3ca1", "refseq_ac": "NP_001353364", "gene_names_uniprotkb": "hist2h3ca1; cb654; si:dkey-23a13.21", "gene_names_refseq": "cb654; hist2h3ca1; si:dkey-23a13.21", "protein_names_uniprotkb": "Histone H3", "protein_names_refseq": "histone 2, H3ca1", "tax_id": 7955, "disease": "", "pathway": " (dre:368227); (R-DRE-110330); (R-DRE-110331); (R-DRE-201722); (R-DRE-212300); (R-DRE-2299718); (R-DRE-2559580); (R-DRE-2559582); (R-DRE-3214815); (R-DRE-3214841); (R-DRE-3214842); (R-DRE-3214847); (R-DRE-3214858); (R-DRE-427359); (R-DRE-427413); (R-DRE-5250924); (R-DRE-5625886); (R-DRE-5693565); (R-DRE-5693571); (R-DRE-5693607); (R-DRE-68616); (R-DRE-73728); (R-DRE-73772); (R-DRE-8936459); (R-DRE-9018519); (R-DRE-9764725); (R-DRE-983231); (R-DRE-9841922); (R-DRE-9843940); (R-DRE-9843970); (R-DRE-9909649); (R-DRE-9940951); (R-DRE-9943411); (R-DRE-9943962)", "pathway_count": 34, "publication_count": 2, "publication_id_list": "21873635;30991053", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR32588728.47669717.1, SRR32588718.856149.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Oct 5, 2018 this sequence version replaced XP_009301168.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3BAR8", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A140LG23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P3L5-1", "uniprot_id": "A0A8M1P3L5_DANRE", "mass": 118883.0, "length": 1067, "protein_name": "Glutamate receptor", "gene_name": "grik5", "organism": "Zebrafish", "refseq_name": "glutamate receptor ionotropic, kainate 5 precursor", "refseq_ac": "NP_001315085", "gene_names_uniprotkb": "grik5", "gene_names_refseq": "grik5", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, kainate 5 precursor", "tax_id": 7955, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dre:798791)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28112265;30827500;34325655", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01022196.1, SRR32588730.28768341.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505388, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IG83;A0AC58HHP6", "ec_number_list": "", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane;GO:0005886 plasma membrane;GO:0032983 kainate selective glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1P3L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NSC9-1", "uniprot_id": "A0A1D5NSC9_DANRE", "mass": 49365.0, "length": 433, "protein_name": "gamma-butyrobetaine dioxygenase", "gene_name": "bbox1", "organism": "Zebrafish", "refseq_name": "gamma-butyrobetaine dioxygenase isoform X1", "refseq_ac": "XP_005168960", "gene_names_uniprotkb": "bbox1; wu:fj14g08; zgc:112179", "gene_names_refseq": "bbox1; wu:fj14g08; zgc:112179", "protein_names_uniprotkb": "gamma-butyrobetaine dioxygenase; 1.14.11.1; Gamma-butyrobetaine hydroxylase; Gamma-butyrobetaine,2-oxoglutarate dioxygenase", "protein_names_refseq": "gamma-butyrobetaine dioxygenase isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-71262)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of L-carnitine from gamma-butyrobetaine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BG71", "ec_number_list": "1.14.11.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008336 gamma-butyrobetaine dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NSC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NT19-1", "uniprot_id": "A0A1D5NT19_DANRE", "mass": 53463.0, "length": 487, "protein_name": "Adrenocortical dysplasia protein homolog isoform 1", "gene_name": "acd", "organism": "Zebrafish", "refseq_name": "adrenocortical dysplasia protein homolog isoform 1", "refseq_ac": "NP_001417988", "gene_names_uniprotkb": "acd; tpp1; zgc:193816", "gene_names_refseq": "acd; tpp1; zgc:193816", "protein_names_uniprotkb": "Adrenocortical dysplasia protein homolog isoform 1", "protein_names_refseq": "adrenocortical dysplasia homolog; adrenocortical dysplasia protein homolog isoform 1; zfTPP1", "tax_id": 7955, "disease": "autosomal dominant dyskeratosis congenita 6 (Disease Ontology:DOID:0070023)", "pathway": " (dre:794664); (R-DRE-110330); (R-DRE-110331); (R-DRE-171319); (R-DRE-174430); (R-DRE-174437)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "21311760;26469318;27189481;28448962;34214617;35150283;35667242", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.194211.1, SRR26395013.192203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 21, 2024 this sequence version replaced XP_005168971.1., [RefSeq]; Knocking down TPP1 led to multiple abnormalities in zebrafish embryogenesis, including neural death, heart malformation, and caudal defect. Erratum:[PLoS One. 2011;6(2).doi: 10.1371/annotation/21d9bc69-ccac-49b8-82f2-a6303e93618a] Publication Status: Online-Only, [RefSeq, PubMed]; This work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BG65", "ec_number_list": "", "go_molecular_function": "GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0070187 shelterin complex;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process;GO:0016233 telomere capping;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0070198 protein localization to chromosome, telomeric region", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A1D5NT19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NT24-1", "uniprot_id": "A0A1D5NT24_DANRE", "mass": 85700.0, "length": 763, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "adam10a", "organism": "Zebrafish", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 10 isoform 1 precursor", "refseq_ac": "NP_001417916", "gene_names_uniprotkb": "adam10a; adam10; wu:fc03d12", "gene_names_refseq": "adam10a; adam10; wu:fc03d12", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 10; 3.4.24.81; Kuzbanian protein homolog", "protein_names_refseq": "a disintegrin and metalloprotease domain 10a; disintegrin and metalloproteinase domain-containing protein 10 isoform 1 precursor", "tax_id": 7955, "disease": "reticulate acropigmentation of Kitamura (Disease Ontology:DOID:0060258); Alzheimer's disease 18 (Disease Ontology:DOID:0110050); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:566044); (R-DRE-1474228); (R-DRE-381426); (R-DRE-6798695); (R-DRE-8957275)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "17439641;19478994;26469318;27185351;28252024;28395729;31042481;33273096", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01009843.1, SRR26395017.1109887.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 25, 2025 this sequence version replaced NP_001417916.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BG63", "ec_number_list": "5.3.4.1;3.1.3.48;3.4.24.81;1.8.3.2;3.1.4.4;3.1.1.98;1.14.14.18;3.6.5.2;3.4.21.112;2.7.11.1", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0046872 metal ion binding;GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097060 synaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A1D5NT24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286Y917-1", "uniprot_id": "A0A286Y917_DANRE", "mass": 129632.0, "length": 1171, "protein_name": "Anillin", "gene_name": "anln", "organism": "Zebrafish", "refseq_name": "anillin isoform X1", "refseq_ac": "XP_005159718", "gene_names_uniprotkb": "anln; si:ch211-197n10.2; wu:fb74d05; wu:fd10d09; wu:fi41f04", "gene_names_refseq": "anln; si:ch211-197n10.2; wu:fb74d05; wu:fd10d09; wu:fi41f04", "protein_names_uniprotkb": "Anillin", "protein_names_refseq": "anillin isoform X1", "tax_id": 7955, "disease": "focal segmental glomerulosclerosis 8 (Disease Ontology:DOID:0111133)", "pathway": " (dre:562517); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013106)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "15520368;24676636;25655700;26147622;26469318;31681410;32676583;34099733;38096821;38165177", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B6G3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005826 actomyosin contractile ring;GO:0032059 bleb", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0003094 glomerular filtration;GO:0008356 asymmetric cell division;GO:0000915 actomyosin contractile ring assembly;GO:0072015 podocyte development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A286Y917-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286Y999-1", "uniprot_id": "A0A286Y999_DANRE", "mass": 166460.0, "length": 1498, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "gene_name": "adamts13", "organism": "Zebrafish", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "refseq_ac": "XP_002663267", "gene_names_uniprotkb": "adamts13", "gene_names_refseq": "adamts13", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "tax_id": 7955, "disease": "hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); disseminated intravascular coagulation (Disease Ontology:DOID:11247); HELLP syndrome (Disease Ontology:DOID:13133); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:100320289); (R-DRE-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_002663267.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RM10", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A286Y999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286YA34-1", "uniprot_id": "A0A286YA34_DANRE", "mass": 57440.0, "length": 508, "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "ppp3cca", "organism": "Zebrafish", "refseq_name": "protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1", "refseq_ac": "XP_005171933", "gene_names_uniprotkb": "ppp3cca; ppp3cc; sb:cb767; si:dkey-21k4.5", "gene_names_refseq": "ppp3cca; ppp3cc; sb:cb767; si:dkey-21k4.5", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase; 3.1.3.16", "protein_names_refseq": "protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1", "tax_id": 7955, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:557926); (R-DRE-111447)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10471505;19500364;28252024;35571926;35600071;36795618;39383064", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BJ63", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A286YA34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286YAT8-1", "uniprot_id": "A0A286YAT8_DANRE", "mass": 106623.0, "length": 935, "protein_name": "Aminopeptidase", "gene_name": "LOC100004744", "organism": "Zebrafish", "refseq_name": "aminopeptidase N", "refseq_ac": "XP_001920418", "gene_names_uniprotkb": "LOC100004744", "gene_names_refseq": "LOC100004744", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "aminopeptidase N", "tax_id": 7955, "disease": "", "pathway": " (dre:100004744)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001920418.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QL77", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A286YAT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286YBK3-1", "uniprot_id": "A0A286YBK3_DANRE", "mass": 74249.0, "length": 652, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "galnt7", "organism": "Zebrafish", "refseq_name": "N-acetylgalactosaminyltransferase 7 isoform X1", "refseq_ac": "XP_005160043", "gene_names_uniprotkb": "galnt7; zgc:112011", "gene_names_refseq": "galnt7; zgc:112011", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "N-acetylgalactosaminyltransferase 7 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-913709)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B6V8", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A286YBK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286YBL8-1", "uniprot_id": "A0A286YBL8_DANRE", "mass": 136946.0, "length": 1204, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "ptpn21", "organism": "Zebrafish", "refseq_name": "tyrosine-protein phosphatase non-receptor type 21 isoform X1", "refseq_ac": "XP_005169845", "gene_names_uniprotkb": "ptpn21", "gene_names_refseq": "ptpn21", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 21 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:799627)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BH12", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0001756 somitogenesis;GO:0001837 epithelial to mesenchymal transition;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A286YBL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8PWG5-1", "uniprot_id": "A0A2R8PWG5_DANRE", "mass": 109379.0, "length": 974, "protein_name": "Pre-mRNA-processing factor 6", "gene_name": "prpf6", "organism": "Zebrafish", "refseq_name": "pre-mRNA-processing factor 6", "refseq_ac": "NP_997820", "gene_names_uniprotkb": "prpf6; c20orf14; fc12b02; wu:fa05f07; wu:fc12b02; zgc:65913", "gene_names_refseq": "c20orf14; fc12b02; prpf6; wu:fa05f07; wu:fc12b02; zgc:65913", "protein_names_uniprotkb": "Pre-mRNA-processing factor 6; PRP6 homolog; U5 snRNP-associated 102 kDa protein", "protein_names_refseq": "pre-mRNA-processing factor 6", "tax_id": 7955, "disease": "retinitis pigmentosa 60 (Disease Ontology:DOID:0110411)", "pathway": " (dre:323855); (R-DRE-72165)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "24419317;24714733;25253178;26137319;26469318;27189481;32703943;37263342", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056710.1, GDQH01015592.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jan 28, 2016 this sequence version replaced NP_997820.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PHV5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A2R8PWG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8PYT0-1", "uniprot_id": "A0A2R8PYT0_DANRE", "mass": 40221.0, "length": 381, "protein_name": "UV excision repair protein RAD23", "gene_name": "rad23b", "organism": "Zebrafish", "refseq_name": "UV excision repair protein RAD23 homolog B", "refseq_ac": "NP_956858", "gene_names_uniprotkb": "rad23b; zgc:65951", "gene_names_refseq": "rad23b; zgc:65951", "protein_names_uniprotkb": "UV excision repair protein RAD23", "protein_names_refseq": "HR23B; UV excision repair protein RAD23 homolog B", "tax_id": 7955, "disease": "", "pathway": " (dre:393536); (R-DRE-532668); (R-DRE-5689877); (R-DRE-5696394); (R-DRE-5696395)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "15520368;17662478;19237207;19467346;24989799;25612249;26469318;27189481;36755921", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01008359.1, BC056578.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1 and EH489133.1. On Aug 21, 2015 this sequence version replaced NP_956858.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PD10", "ec_number_list": "1.14.99.66;1.14.11.-;1.14.11.65", "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0043130 ubiquitin binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A2R8PYT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q1D2-1", "uniprot_id": "A0A2R8Q1D2_DANRE", "mass": 14223.0, "length": 127, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit P", "gene_name": "pigp", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit P", "refseq_ac": "NP_956006", "gene_names_uniprotkb": "pigp; dscr5; wu:fc66d08; zgc:73366", "gene_names_refseq": "dscr5; pigp; wu:fc66d08; zgc:73366", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit P", "protein_names_refseq": "Down syndrome critical region gene 5; phosphatidylinositol N-acetylglucosaminyltransferase subunit P; phosphatidylinositol glycan, class P", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 55 (Disease Ontology:DOID:0080283)", "pathway": " (dre:325316)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16109975;19465602;37175447;38805544", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EV760897.1, DN765438.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jan 29, 2016 this sequence version replaced NP_956006.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PBS0", "ec_number_list": "", "go_molecular_function": "GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0046328 regulation of JNK cascade;GO:0060028 convergent extension involved in axis elongation;GO:0006506 GPI anchor biosynthetic process;GO:0060026 convergent extension;GO:1904103 regulation of convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A2R8Q1D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q1X2-1", "uniprot_id": "A0A2R8Q1X2_DANRE", "mass": 47246.0, "length": 432, "protein_name": "phosphopyruvate hydratase", "gene_name": "eno1a", "organism": "Zebrafish", "refseq_name": "enolase 1a, (alpha) isoform X1", "refseq_ac": "XP_005162209", "gene_names_uniprotkb": "eno1a; eno1; wu:fi32b03; wu:fk58e02; zgc:73152", "gene_names_refseq": "eno1a; eno1; wu:fi32b03; wu:fk58e02; zgc:73152", "protein_names_uniprotkb": "phosphopyruvate hydratase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11", "protein_names_refseq": "enolase 1a, (alpha) isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763)", "pathway": " (R-DRE-70171); (R-DRE-70263)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B8Z4", "ec_number_list": "4.2.1.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0000015 phosphopyruvate hydratase complex", "go_biological_process": "GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q1X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q3V6-1", "uniprot_id": "A0A2R8Q3V6_DANRE", "mass": 94935.0, "length": 848, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17a isoform X1", "gene_name": "adam17a", "organism": "Zebrafish", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 17a isoform X1", "refseq_ac": "XP_005158775", "gene_names_uniprotkb": "adam17a; fc20b01; wu:fc20b01; zgc:63886", "gene_names_refseq": "adam17a; fc20b01; wu:fc20b01; zgc:63886", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 17a isoform X1", "protein_names_refseq": "disintegrin and metalloproteinase domain-containing protein 17a isoform X1", "tax_id": 7955, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); neonatal inflammatory skin and bowel disease 1 (Disease Ontology:DOID:0061192); Alzheimer's disease (Disease Ontology:DOID:10652); atopic dermatitis (Disease Ontology:DOID:3310); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-DRE-193692); (R-DRE-75893)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B5L3", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q3V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q5P7-1", "uniprot_id": "A0A2R8Q5P7_DANRE", "mass": 77449.0, "length": 676, "protein_name": "Protein kinase C", "gene_name": "prkchb", "organism": "Zebrafish", "refseq_name": "protein kinase C, eta, b isoform X1", "refseq_ac": "XP_005160557", "gene_names_uniprotkb": "prkchb; prkch; si:ch211-212g7.5", "gene_names_refseq": "prkchb; prkch; si:ch211-212g7.5", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "protein kinase C, eta, b isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B7B5", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0007611 learning or memory;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q5P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q650-1", "uniprot_id": "A0A2R8Q650_DANRE", "mass": 33017.0, "length": 284, "protein_name": "Tropomyosin alpha-3 chain isoform X1", "gene_name": "tpm3", "organism": "Zebrafish", "refseq_name": "tropomyosin alpha-3 chain isoform X1", "refseq_ac": "XP_005159432", "gene_names_uniprotkb": "tpm3; cb674; fa17b11; fb83b01; fk41e01; hm:zeh0298; wu:fa17b11; wu:fb83b01; wu:fk41e01; zeh0298; zgc:77592", "gene_names_refseq": "cb674; fa17b11; fb83b01; fk41e01; hm:zeh0298; tpm3; wu:fa17b11; wu:fb83b01; wu:fk41e01; zeh0298; zgc:77592", "protein_names_uniprotkb": "Tropomyosin alpha-3 chain isoform X1", "protein_names_refseq": "tropomyosin alpha-3 chain isoform X1", "tax_id": 7955, "disease": "congenital myopathy 4A (Disease Ontology:DOID:0080102); congenital myopathy 4B (Disease Ontology:DOID:0110926); dilated cardiomyopathy (Disease Ontology:DOID:12930); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B5V8", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005856 cytoskeleton", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0006936 muscle contraction;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q650-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q7I3-1", "uniprot_id": "A0A2R8Q7I3_DANRE", "mass": 117579.0, "length": 1020, "protein_name": "Apoptosis-resistant E3 ubiquitin protein ligase 1", "gene_name": "arel1", "organism": "Zebrafish", "refseq_name": "apoptosis-resistant E3 ubiquitin protein ligase 1", "refseq_ac": "XP_002663081", "gene_names_uniprotkb": "arel1", "gene_names_refseq": "arel1", "protein_names_uniprotkb": "Apoptosis-resistant E3 ubiquitin protein ligase 1; 2.3.2.26; Apoptosis-resistant HECT-type E3 ubiquitin transferase 1", "protein_names_refseq": "apoptosis-resistant E3 ubiquitin protein ligase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100332031); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002663081.1. COMPLETENESS: full length., [RefSeq]; E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro. Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1RDN9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007399 nervous system development;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8Q7I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q7T0-1", "uniprot_id": "A0A2R8Q7T0_DANRE", "mass": 94664.0, "length": 826, "protein_name": "Tyrosine-protein kinase", "gene_name": "fes", "organism": "Zebrafish", "refseq_name": "tyrosine-protein kinase Fes/Fps", "refseq_ac": "NP_001186798", "gene_names_uniprotkb": "fes", "gene_names_refseq": "fes", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "feline sarcoma oncogene; tyrosine-protein kinase Fes/Fps", "tax_id": 7955, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:566739)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23234507;24926785;25684355;26469318;27189481;28626217;30929901", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505388, SAMEA4476732 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NXI9", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A2R8Q7T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q8G0-1", "uniprot_id": "A0A2R8Q8G0_DANRE", "mass": 17049.0, "length": 153, "protein_name": "Mitochondrial fission 1 protein", "gene_name": "fis1", "organism": "Zebrafish", "refseq_name": "mitochondrial fission 1 protein", "refseq_ac": "NP_001297772", "gene_names_uniprotkb": "fis1; im:6905231; si:dkey-1c17.5", "gene_names_refseq": "fis1; im:6905231; si:dkey-1c17.5", "protein_names_uniprotkb": "Mitochondrial fission 1 protein", "protein_names_refseq": "mitochondrial fission 1 protein", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dre:797988); (R-DRE-9603798)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "25792259;27189481;27497958;30208422;30846767;36428971;37509008;38032938;38530354;38710511", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH539185.1, BC054679.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505375, SAMEA3505382 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH539185.1 and EH473113.1. On or before Sep 3, 2015 this sequence version replaced XP_005172294.1, NP_001297772.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis., [UniProtKB, UniProtKB]; To our knowledge, our study is the first composite analysis of sirtuins in adult zebrafish retina and provides sufficient evidence that resveratrol, as an activator of SIRT1, protects NMDA-induced zebrafish retinal damage by potentially mediating mitochondrial sirtuins and OPA1 genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P7J1", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016559 peroxisome fission;GO:0055088 lipid homeostasis;GO:0006915 apoptotic process;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A2R8Q8G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q8S1-1", "uniprot_id": "A0A2R8Q8S1_DANRE", "mass": 21771.0, "length": 189, "protein_name": "small monomeric GTPase", "gene_name": "kras", "organism": "Zebrafish", "refseq_name": "GTPase KRas isoform 1", "refseq_ac": "NP_001349423", "gene_names_uniprotkb": "kras; K-ras; fa04e08; fc14b12; fc23g10; fj89d12; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; xRAS2; zgc:85725", "gene_names_refseq": "K-ras; fa04e08; fc14b12; fc23g10; fj89d12; kras; wu:fa04e08; wu:fc14b12; wu:fc23g10; wu:fj89d12; xRAS2; zgc:85725", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "GTPase KRas isoform 1; GTPase KRas; ras-like protein", "tax_id": 7955, "disease": "cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); Noonan syndrome 3 (Disease Ontology:DOID:0060581); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); endometrial hyperplasia (Disease Ontology:DOID:0080365); autoimmune lymphoproliferative syndrome type 4 (Disease Ontology:DOID:0110117); cardiofaciocutaneous syndrome 2 (Disease Ontology:DOID:0111461); linear nevus sebaceous syndrome (Disease Ontology:DOID:0111530); oculoectodermal syndrome (Disease Ontology:DOID:0111705); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); anaplastic astrocytoma (Disease Ontology:DOID:3078); Noonan syndrome (Disease Ontology:DOID:3490); Lynch syndrome (Disease Ontology:DOID:3883); lung adenocarcinoma (Disease Ontology:DOID:3910); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); Klatskin's tumor (Disease Ontology:DOID:4927); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); stomach carcinoma (Disease Ontology:DOID:5517); fibrillary astrocytoma (Disease Ontology:DOID:6726); hepatocellular carcinoma (Disease Ontology:DOID:684); pancreatic mucinous cystadenoma (Disease Ontology:DOID:7235); myeloid sarcoma (Disease Ontology:DOID:8683); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-DRE-1169092); (R-DRE-1250347); (R-DRE-1433557); (R-DRE-179812); (R-DRE-180336); (R-DRE-186763); (R-DRE-1963640); (R-DRE-210993); (R-DRE-2179392); (R-DRE-375165); (R-DRE-5621575); (R-DRE-5654688); (R-DRE-5654693); (R-DRE-5654699); (R-DRE-5654700); (R-DRE-5654704); (R-DRE-5654706); (R-DRE-5654712); (R-DRE-5654719); (R-DRE-5658442); (R-DRE-5673000); (R-DRE-5673001); (R-DRE-5674135); (R-DRE-5675221); (R-DRE-8849471); (R-DRE-8851805); (R-DRE-9607240); (R-DRE-9648002)", "pathway_count": 28, "publication_count": 10, "publication_id_list": "18544450;18682746;19470611;19500364;19961491;37154160;37155312;37251325;38791872;38795642", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395012.1489697.1, SRR32588733.384484.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Aug 27, 2018 this sequence version replaced XP_009296393.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AZT3", "ec_number_list": "2.7.11.1;3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;2.7.1.153;3.4.26.1;3.1.2.22;2.7.1.137;3.1.3.48;2.7.10.1;2.7.10.2;3.1.3.16;3.6.1.-;3.6.4.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0007265 Ras protein signal transduction;GO:0030097 hemopoiesis;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A2R8Q8S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8Q922-1", "uniprot_id": "A0A2R8Q922_DANRE", "mass": 23334.0, "length": 222, "protein_name": "Claudin", "gene_name": "cldn15lb", "organism": "Zebrafish", "refseq_name": "claudin 15-like b", "refseq_ac": "NP_001002446", "gene_names_uniprotkb": "cldn15lb; cldn10l1b; zgc:92349", "gene_names_refseq": "cldn10l1b; cldn15lb; zgc:92349", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "claudin 10-like 1b; claudin 15-like b", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "22020048;23726886;27189481;32793187", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH504874.1, BC076025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH497153.1 and EH487007.1. On Sep 30, 2011 this sequence version replaced NP_001002446.1., [RefSeq]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cldn15lb plays an important role in the remodeling process during biliary duct morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N0I3", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0035622 intrahepatic bile duct development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A2R8Q922-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QAF5-1", "uniprot_id": "A0A2R8QAF5_DANRE", "mass": 51593.0, "length": 451, "protein_name": "Gamma-aminobutyric acid receptor subunit pi", "gene_name": "LOC562831", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid receptor subunit pi", "refseq_ac": "XP_009305888", "gene_names_uniprotkb": "LOC562831", "gene_names_refseq": "LOC562831", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit pi; GABA(A) receptor subunit pi", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit pi", "tax_id": 7955, "disease": "", "pathway": " (dre:562831)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone. In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AZI4", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3", "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8QAF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QAL3-1", "uniprot_id": "A0A2R8QAL3_DANRE", "mass": 503200.0, "length": 4601, "protein_name": "Protocadherin Fat 3a isoform X1", "gene_name": "fat3a", "organism": "Zebrafish", "refseq_name": "protocadherin Fat 3a isoform X1", "refseq_ac": "XP_017206475", "gene_names_uniprotkb": "fat3a; fat3; zgc:153498", "gene_names_refseq": "fat3a; fat3; zgc:153498", "protein_names_uniprotkb": "Protocadherin Fat 3a isoform X1", "protein_names_refseq": "protocadherin Fat 3a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569256)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "24244857;25340762;26469318;26818140;27189481;28252024;33071966;33164759", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M6YUT6;A0AC58HBE7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0043005 neuron projection;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0016358 dendrite development;GO:0001764 neuron migration;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060536 cartilage morphogenesis;GO:0048646 anatomical structure formation involved in morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A2R8QAL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QFF0-1", "uniprot_id": "A0A2R8QFF0_DANRE", "mass": 70361.0, "length": 644, "protein_name": "Solute carrier organic anion transporter family member", "gene_name": "slco1f4", "organism": "Zebrafish", "refseq_name": "solute carrier organic anion transporter family, member 1F4", "refseq_ac": "NP_001074135", "gene_names_uniprotkb": "slco1f4; Oatp1f4; zgc:158438", "gene_names_refseq": "Oatp1f4; slco1f4; zgc:158438", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member", "protein_names_refseq": "solute carrier anion transporting family member 1f4; solute carrier organic anion transporter family, member 1F4", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-159418); (R-DRE-879518); (R-DRE-9793528)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19931635;24113777;26055554;26308493;30965663", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129232.1, SRR32588725.24645521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715699, SAMN18715720 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Sep 21, 2011 this sequence version replaced NP_001074135.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NBS3;A0AC58J8I6", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0009725 response to hormone;GO:0043252 sodium-independent organic anion transport;GO:1905431 microcystin transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A2R8QFF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QJH4-1", "uniprot_id": "A0A2R8QJH4_DANRE", "mass": 110795.0, "length": 1005, "protein_name": "Calcium-transporting ATPase", "gene_name": "atp2a3", "organism": "Zebrafish", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1", "refseq_ac": "XP_697108", "gene_names_uniprotkb": "atp2a3", "gene_names_refseq": "atp2a3", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568671); (R-DRE-418359); (R-DRE-5578775); (R-DRE-936837)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_697108.4. COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TFK9", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8QJH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QKN2-1", "uniprot_id": "A0A2R8QKN2_DANRE", "mass": 25677.0, "length": 227, "protein_name": "Homeobox protein prophet of Pit-1", "gene_name": "prop1", "organism": "Zebrafish", "refseq_name": "PROP paired-like homeobox 1", "refseq_ac": "NP_001170932", "gene_names_uniprotkb": "prop1; si:ch211-93n23.5", "gene_names_refseq": "prop1; si:ch211-93n23.5", "protein_names_uniprotkb": "Homeobox protein prophet of Pit-1; Pituitary-specific homeodomain factor", "protein_names_refseq": "PROP paired-like homeobox 1; paired-like homeodomain transcription factor prop1", "tax_id": 7955, "disease": "combined pituitary hormone deficiency 2 (Disease Ontology:DOID:0061020); hypogonadism (Disease Ontology:DOID:1924); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (dre:100001377)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21362424;27027936;33093109;39449741", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU848298.1, SRR32588730.23829132.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN18715637, SAMN18715719 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Jun 25, 2025 this sequence version replaced NP_001170932.2., [RefSeq]; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NVQ6", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A2R8QKN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QL27-1", "uniprot_id": "A0A2R8QL27_DANRE", "mass": 51352.0, "length": 436, "protein_name": "Carbohydrate sulfotransferase", "gene_name": "chst12a", "organism": "Zebrafish", "refseq_name": "carbohydrate sulfotransferase 12", "refseq_ac": "NP_998712", "gene_names_uniprotkb": "chst12a; chst12; csht12; zC4ST-2; zgc:193508; zgc:193523", "gene_names_refseq": "chst12a; chst12; csht12; zC4ST-2; zgc:193508; zgc:193523", "protein_names_uniprotkb": "Carbohydrate sulfotransferase; 2.8.2.-", "protein_names_refseq": "C4ST-2; carbohydrate (chondroitin 4) sulfotransferase 12; carbohydrate sulfotransferase 12; chondroitin 4-sulfotransferase-2", "tax_id": 7955, "disease": "", "pathway": " (dre:407076); (R-DRE-2022870)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19125692;25793894;26469318;30929901;31053140;31193955", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC162067.1, AB122017.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC162067.1. On Sep 30, 2011 this sequence version replaced NP_998712.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PJP0", "ec_number_list": "2.8.2.-;2.8.2.5", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A2R8QL27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QLT6-1", "uniprot_id": "A0A2R8QLT6_DANRE", "mass": 38954.0, "length": 355, "protein_name": "Lymphatic vessel endothelial hyaluronic receptor 1b precursor", "gene_name": "lyve1b", "organism": "Zebrafish", "refseq_name": "lymphatic vessel endothelial hyaluronic receptor 1b precursor", "refseq_ac": "NP_001314826", "gene_names_uniprotkb": "lyve1b; fj84c10; lyve1l; lyve1; si:dkey-5a9.3; wu:fj84c10", "gene_names_refseq": "fj84c10; lyve1b; lyve1l; lyve1; si:dkey-5a9.3; wu:fj84c10", "protein_names_uniprotkb": "Lymphatic vessel endothelial hyaluronic receptor 1b precursor", "protein_names_refseq": "lymphatic vessel endothelial hyaluronic acid receptor 1b; lymphatic vessel endothelial hyaluronic acid receptor 1; lymphatic vessel endothelial hyaluronic receptor 1b precursor; lyve-1", "tax_id": 7955, "disease": "", "pathway": " (dre:564249)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;19287381;19504456;20549745;20976189;36105188;36205097;37679366;39013903;39101673", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01022136.1, GDQQ01007728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000018.1. On May 27, 2016 this sequence version replaced XP_692685.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P976", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A2R8QLT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QPJ6-1", "uniprot_id": "A0A2R8QPJ6_DANRE", "mass": 212329.0, "length": 1902, "protein_name": "Plexin-A2", "gene_name": "plxna2", "organism": "Zebrafish", "refseq_name": "plexin-A2", "refseq_ac": "XP_689780", "gene_names_uniprotkb": "plxna2", "gene_names_refseq": "plxna2", "protein_names_uniprotkb": "Plexin-A2", "protein_names_refseq": "plexin-A2", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-399954); (R-DRE-399956)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_689780.4. COMPLETENESS: full length., [RefSeq]; Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7T7K8;A0AC58IM61;A0AC58IM62;A0AC58IM63;A0AC58IM64;A0AC58IM67;A0AC58IM68;A0AC58IM69;A0AC58IM70;A0AC58IM71;A0AC58IM72;A0AC58IM76;A0AC58IM89;A0AC58IM92;A0AC58IMD3", "ec_number_list": "", "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0035295 tube development;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8QPJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QPS5-1", "uniprot_id": "RIC1_DANRE", "mass": 148264.0, "length": 1321, "protein_name": "Guanine nucleotide exchange factor subunit RIC1", "gene_name": "ric1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ric1", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine nucleotide exchange factor subunit RIC1; Protein RIC1 homolog; RAB6A-GEF complex partner 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "31932796", "class_list": "", "function": "The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may be thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (By similarity). It is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex;GO:0000139 Golgi membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A2R8QPS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8QQN0-1", "uniprot_id": "A0A2R8QQN0_DANRE", "mass": 64063.0, "length": 582, "protein_name": "Solute carrier family 13 member 5a isoform X1", "gene_name": "slc13a5a", "organism": "Zebrafish", "refseq_name": "solute carrier family 13 member 5a isoform X1", "refseq_ac": "XP_005161489", "gene_names_uniprotkb": "slc13a5a; fd44c11; im:7245905; si:ch211-221p4.4; slc13a5; wu:fd44c11", "gene_names_refseq": "fd44c11; im:7245905; si:ch211-221p4.4; slc13a5a; slc13a5; wu:fd44c11", "protein_names_uniprotkb": "Solute carrier family 13 member 5a isoform X1", "protein_names_refseq": "solute carrier family 13 member 5a isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 25 (Disease Ontology:DOID:0080453)", "pathway": " (dre:503788)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "25617245;25778530;26469318;27287540;27357367;31053140", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B8B2", "ec_number_list": "", "go_molecular_function": "GO:0015137 citrate transmembrane transporter activity;GO:0017153 sodium:dicarboxylate symporter activity;GO:0015141 succinate transmembrane transporter activity;GO:0015370 solute:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015746 citrate transport;GO:0015729 oxaloacetate transport;GO:0015744 succinate transport;GO:0015741 fumarate transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A2R8QQN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8RK22-1", "uniprot_id": "A0A2R8RK22_DANRE", "mass": 109088.0, "length": 993, "protein_name": "Calcium-transporting ATPase", "gene_name": "atp2a1l", "organism": "Zebrafish", "refseq_name": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1", "refseq_ac": "XP_005156129", "gene_names_uniprotkb": "atp2a1l; im:7145237; si:ch211-198p7.3; zgc:154094", "gene_names_refseq": "atp2a1l; im:7145237; si:ch211-198p7.3; zgc:154094", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B2Q3", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8RK22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8RNG4-1", "uniprot_id": "A0A2R8RNG4_DANRE", "mass": 40976.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein subunit alpha", "gene_name": "gna14a", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein subunit alpha-14 isoform X1", "refseq_ac": "XP_683989", "gene_names_uniprotkb": "gna14a", "gene_names_refseq": "gna14a", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha", "protein_names_refseq": "guanine nucleotide-binding protein subunit alpha-14 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-112043); (R-DRE-202040); (R-DRE-416476); (R-DRE-418592); (R-DRE-428930); (R-DRE-456926)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Feb 15, 2007 this sequence version replaced XP_683989.1. COMPLETENESS: full length., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8N7TCS1", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0001508 action potential;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8RNG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8RTM3-1", "uniprot_id": "A0A2R8RTM3_DANRE", "mass": 27194.0, "length": 245, "protein_name": "Paralemmin-1", "gene_name": "palm1b", "organism": "Zebrafish", "refseq_name": "paralemmin 1b isoform X1", "refseq_ac": "XP_005163451", "gene_names_uniprotkb": "palm1b; zgc:63523", "gene_names_refseq": "palm1b; zgc:63523", "protein_names_uniprotkb": "Paralemmin-1; Paralemmin", "protein_names_refseq": "paralemmin 1b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAU0;A0AC58GIN9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0043197 dendritic spine;GO:0098794 postsynapse;GO:0030175 filopodium", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008360 regulation of cell shape;GO:0051491 positive regulation of filopodium assembly;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8RTM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8RXI8-1", "uniprot_id": "A0A2R8RXI8_DANRE", "mass": 113157.0, "length": 1017, "protein_name": "Mitogen-activated protein kinase kinase kinase", "gene_name": "map3k21", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase 21 isoform X1", "refseq_ac": "XP_005156983", "gene_names_uniprotkb": "map3k21", "gene_names_refseq": "map3k21", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 21 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:561518)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B398", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0004706 JUN kinase kinase kinase activity;GO:0004709 MAP kinase kinase kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8RXI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8RXU6-1", "uniprot_id": "A0A2R8RXU6_DANRE", "mass": 131636.0, "length": 1179, "protein_name": "protein-serine/threonine phosphatase", "gene_name": "ssh2b", "organism": "Zebrafish", "refseq_name": "protein phosphatase Slingshot homolog 2b isoform X1", "refseq_ac": "XP_009293925", "gene_names_uniprotkb": "ssh2b; zgc:175142", "gene_names_refseq": "ssh2b; zgc:175142", "protein_names_uniprotkb": "protein-serine/threonine phosphatase; 3.1.3.16", "protein_names_refseq": "protein phosphatase Slingshot homolog 2b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AX49", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0003779 actin binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A2R8RXU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A2R8RY99-1", "uniprot_id": "CLRN2_DANRE", "mass": 25835.0, "length": 233, "protein_name": "Clarin-2", "gene_name": "clrn2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "clrn2; si:dkey-245p14.5", "gene_names_refseq": "", "protein_names_uniprotkb": "Clarin-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;33496845", "class_list": "", "function": "Plays a key role to hearing function. Required for normal organization and maintenance of the stereocilia bundle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0060171 stereocilium membrane;GO:0070451 cell hair", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A2R8RY99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P861-1", "uniprot_id": "A0A8M1P861_DANRE", "mass": 38685.0, "length": 354, "protein_name": "Malate dehydrogenase", "gene_name": "mdh1aa", "organism": "Zebrafish", "refseq_name": "malate dehydrogenase 1Aa, NAD (soluble) isoform mdh1x", "refseq_ac": "NP_001303854", "gene_names_uniprotkb": "mdh1aa; MDH1; fj05b08; mdh1a; mdhA; wu:fj05b08; zgc:63941", "gene_names_refseq": "MDH1; fj05b08; mdh1aa; mdh1a; mdhA; wu:fj05b08; zgc:63941", "protein_names_uniprotkb": "Malate dehydrogenase; 1.1.1.37", "protein_names_refseq": "MDH1b; malate dehydrogenase 1Aa, NAD (soluble) isoform mdh1x; malate dehydrogenase 1a, NAD (soluble)", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 88 (Disease Ontology:DOID:0112222)", "pathway": " (dre:399662)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11726686;12612830;16109975;19500364;20528263;25340584;27189481;28252024;31187491;35295584;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY161294.1, BC053158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## stop codon readthrough :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EG578573.1, BC053158.1 and AW281946.1. This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Teleost fish express two cytosolic isozymes: one is ubiquitously expressed and the other is expressed predominantly in the eye and skeletal muscle. This gene encodes the ubiquitously expressed isozyme. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. A paralog of this gene is found on chromosome 17. [provided by RefSeq, Sep 2017]. Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (mdh1) results from translation termination at the upstream UGA stop codon, while the longer isoform (mdh1x) results from UGA stop codon readthrough to the downstream UAA termination codon. This RefSeq represents the longer, C-terminally extended isoform (mdh1x), which is localized in the peroxisomes. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.37", "go_molecular_function": "GO:0030060 L-malate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006108 malate metabolic process;GO:0006107 oxaloacetate metabolic process;GO:0019674 NAD+ metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1P861-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N1J9-1", "uniprot_id": "A0A8M1N1J9_DANRE", "mass": 40027.0, "length": 352, "protein_name": "Glucose-6-phosphatase", "gene_name": "g6pc1a.1", "organism": "Zebrafish", "refseq_name": "glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 1", "refseq_ac": "NP_001003512", "gene_names_uniprotkb": "g6pc1a.1; cb822; g6pca.1; g6pca; g6pc; zgc:92368", "gene_names_refseq": "cb822; g6pc1a.1; g6pca.1; g6pca; g6pc; zgc:92368", "protein_names_uniprotkb": "Glucose-6-phosphatase; 3.1.3.9", "protein_names_refseq": "glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1; glucose-6-phosphatase a, catalytic, tandem duplicate 1; glucose-6-phosphatase, catalytic", "tax_id": 7955, "disease": "glycogen storage disease Ia (Disease Ontology:DOID:2749); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:445118)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18803835;19200601;22047996;23201900;23659367;38732518;38803914;38805544;39075492;39159974", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076446.1, SRR32588723.1484816.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On Jul 17, 2025 this sequence version replaced NP_001003512.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1Q559", "ec_number_list": "3.1.3.9", "go_molecular_function": "GO:0004346 glucose-6-phosphatase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0048878 chemical homeostasis;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1N1J9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N295-1", "uniprot_id": "A0A8M1N295_DANRE", "mass": 21651.0, "length": 190, "protein_name": "Glutathione peroxidase", "gene_name": "gpx1b", "organism": "Zebrafish", "refseq_name": "glutathione peroxidase 1b", "refseq_ac": "NP_001004634", "gene_names_uniprotkb": "gpx1b; wu:fd42f12; wu:fj22d06; zgc:101700", "gene_names_refseq": "gpx1b; wu:fd42f12; wu:fj22d06; zgc:101700", "protein_names_uniprotkb": "Glutathione peroxidase", "protein_names_refseq": "glutathione peroxidase 1b", "tax_id": 7955, "disease": "Keshan disease (Disease Ontology:DOID:0050083); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); myeloid neoplasm (Disease Ontology:DOID:0070004); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); iron deficiency anemia (Disease Ontology:DOID:11758); nephrotic syndrome (Disease Ontology:DOID:1184); leukemia (Disease Ontology:DOID:1240); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); calcinosis (Disease Ontology:DOID:182); colon cancer (Disease Ontology:DOID:219); anemia (Disease Ontology:DOID:2355); nephrosis (Disease Ontology:DOID:2527); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); hairy cell leukemia (Disease Ontology:DOID:285); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); coronary artery disease (Disease Ontology:DOID:3393); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); Crohn's disease (Disease Ontology:DOID:8778); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:447895)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11168591;12915322;15070763;16109975;23770340;25064324;35203601;37024546;37031846;38042913", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH520320.1, GFIL01011906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EH492461.1, EH503547.1 and EH520320.1. On Mar 6, 2008 this sequence version replaced NP_001004634.1. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Zebrafish has two paralogs of this isozyme (gpx1a and gpx1b), which exhibit different temporal expression during development. Both are selenoproteins, containing the rare amino acid selenocysteine (Sec) at their active sites. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 49, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.9", "go_molecular_function": "GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042542 response to hydrogen peroxide;GO:0034599 cellular response to oxidative stress;GO:0010269 response to selenium ion;GO:0042744 hydrogen peroxide catabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1N295-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PAF3-1", "uniprot_id": "A0A8M1PAF3_DANRE", "mass": 21936.0, "length": 194, "protein_name": "Glutathione peroxidase", "gene_name": "gpx4a", "organism": "Zebrafish", "refseq_name": "glutathione peroxidase 4a isoform 1 precursor", "refseq_ac": "NP_001333466", "gene_names_uniprotkb": "gpx4a; PHGPxa; cb563; cb691; sb:cb563; wu:fb82e03; zgc:92253", "gene_names_refseq": "PHGPxa; cb563; cb691; gpx4a; sb:cb563; wu:fb82e03; zgc:92253", "protein_names_uniprotkb": "Glutathione peroxidase", "protein_names_refseq": "glutathione peroxidase 4a isoform 1 precursor", "tax_id": 7955, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); spondylometaphyseal dysplasia Sedaghatian type (Disease Ontology:DOID:0112298); pre-eclampsia (Disease Ontology:DOID:10591); nephrotic syndrome (Disease Ontology:DOID:1184); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); gastric adenocarcinoma (Disease Ontology:DOID:3717); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:352928)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11168591;12915322;18302988;22479358;23770340;26315538;37714372;37977545;38042913;38788853", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH594416.1, EH463305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476800 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EH454234.1 and EH584097.1. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development. This isozyme is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A paralog of this gene is present on chromosome 2. Each paralog has a distinct pattern of expression during embryonic development. [provided by RefSeq, Aug 2017]. Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005634 nucleus", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006979 response to oxidative stress;GO:0034599 cellular response to oxidative stress;GO:0019372 lipoxygenase pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1PAF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P8S9-1", "uniprot_id": "A0A8M1P8S9_DANRE", "mass": 30093.0, "length": 264, "protein_name": "Iodothyronine deiodinase", "gene_name": "dio1", "organism": "Zebrafish", "refseq_name": "type I iodothyronine deiodinase isoform 2", "refseq_ac": "NP_001311333", "gene_names_uniprotkb": "dio1; Deio1; cb685; zgc:92323", "gene_names_refseq": "Deio1; cb685; dio1; zgc:92323", "protein_names_uniprotkb": "Iodothyronine deiodinase", "protein_names_refseq": "deiodinase, iodothyronine, type I; type I iodothyronine deiodinase isoform 2", "tax_id": 7955, "disease": "thyroid gland disease (Disease Ontology:DOID:50)", "pathway": " (dre:799937)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12915322;15520368;16872691;17418841;19703701;36769379;37600710;38042913;38717324;39413646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY221259.1, SRR32588716.3828029.1 [ECO:0000332] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JBMGRA010000008.1. On Dec 18, 2025 this sequence version replaced NP_001311333.1. The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0061074 regulation of neural retina development;GO:0042446 hormone biosynthetic process;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P8S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N370-1", "uniprot_id": "A0A8M1N370_DANRE", "mass": 21764.0, "length": 191, "protein_name": "Glutathione peroxidase", "gene_name": "gpx1a", "organism": "Zebrafish", "refseq_name": "glutathione peroxidase 1a", "refseq_ac": "NP_001007282", "gene_names_uniprotkb": "gpx1a; cb690; gpx1; zgc:103683; zgc:92737", "gene_names_refseq": "cb690; gpx1a; gpx1; zgc:103683; zgc:92737", "protein_names_uniprotkb": "Glutathione peroxidase", "protein_names_refseq": "glutathione peroxidase 1a; glutathione peroxidase 1", "tax_id": 7955, "disease": "Keshan disease (Disease Ontology:DOID:0050083); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); myeloid neoplasm (Disease Ontology:DOID:0070004); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); iron deficiency anemia (Disease Ontology:DOID:11758); nephrotic syndrome (Disease Ontology:DOID:1184); leukemia (Disease Ontology:DOID:1240); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); calcinosis (Disease Ontology:DOID:182); colon cancer (Disease Ontology:DOID:219); anemia (Disease Ontology:DOID:2355); nephrosis (Disease Ontology:DOID:2527); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); hairy cell leukemia (Disease Ontology:DOID:285); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); coronary artery disease (Disease Ontology:DOID:3393); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); Crohn's disease (Disease Ontology:DOID:8778); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:352926)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10908323;11168591;12915322;15533794;23770340;25064324;38283058;38420496;38717324;39029645", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC083461.1, EH454770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EH454770.1 and BC083461.1. On Mar 5, 2008 this sequence version replaced NP_001007282.1. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Zebrafish has two paralogs of this isozyme (gpx1a and gpx1b), which exhibit different temporal expression during development. Both are selenoproteins, containing the rare amino acid selenocysteine (Sec) at their active sites. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 49, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.9", "go_molecular_function": "GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0042542 response to hydrogen peroxide;GO:0034599 cellular response to oxidative stress;GO:0010269 response to selenium ion;GO:0042744 hydrogen peroxide catabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1N370-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N4I9-1", "uniprot_id": "A0A8M1N4I9_DANRE", "mass": 86311.0, "length": 754, "protein_name": "Amine oxidase", "gene_name": "aoc2", "organism": "Zebrafish", "refseq_name": "retina-specific copper amine oxidase", "refseq_ac": "NP_001013573", "gene_names_uniprotkb": "aoc2; aoc3; fa94a08; fe14c05; wu:fa94a08; wu:fe14c05; zgc:113006", "gene_names_refseq": "aoc2; aoc3; fa94a08; fe14c05; wu:fa94a08; wu:fe14c05; zgc:113006", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "amine oxidase, copper containing 3; retina-specific copper amine oxidase", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); intracranial aneurysm (Disease Ontology:DOID:10941); uveitis (Disease Ontology:DOID:13141); aortic aneurysm (Disease Ontology:DOID:3627); congestive heart failure (Disease Ontology:DOID:6000); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:541429)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18803835;22046393;28252024;28757199;32390373;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004239.1, GDQQ01000866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476795, SAMEA4476823 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000003.1. On Jun 19, 2008 this sequence version replaced NP_001013573.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M1N4I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N4J3-1", "uniprot_id": "A0A8M1N4J3_DANRE", "mass": 102314.0, "length": 898, "protein_name": "Eukaryotic translation initiation factor 4 gamma 2", "gene_name": "eif4g2b", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 4 gamma 2b", "refseq_ac": "NP_001013461", "gene_names_uniprotkb": "eif4g2b; NAT1B; eif4g2; fb44h01; hm:zeh1307; wu:fa14h01; wu:fb44h01; wu:fb59c06; wu:fc21b05", "gene_names_refseq": "NAT1B; eif4g2b; eif4g2; fb44h01; hm:zeh1307; wu:fa14h01; wu:fb44h01; wu:fb59c06; wu:fc21b05", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4 gamma 2", "protein_names_refseq": "eukaryotic translation initiation factor 4 gamma 2b; eukaryotic translation initiation factor 4 gamma, 2", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); renovascular hypertension (Disease Ontology:DOID:1591)", "pathway": " (dre:334618)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11116086;11116087;15520368;15718103;16109975;17237356;29201571;29506474", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC109409.1, AB096101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 15718103 ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EB934789.1 and BC109409.1. On Sep 21, 2007 this sequence version replaced NP_001013461.1., [RefSeq]; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases., [UniProtKB, UniProtKB]; The exclusive use of the non-AUG (GUG) start site for translation initiation of EIF4G2 mRNA is evolutionary conserved in mammals and non-mammals., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M1N4J3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N6X6-1", "uniprot_id": "A0A8M1N6X6_DANRE", "mass": 51129.0, "length": 456, "protein_name": "Mothers against decapentaplegic homolog", "gene_name": "smad6a", "organism": "Zebrafish", "refseq_name": "mothers against decapentaplegic homolog 6a", "refseq_ac": "NP_001019981", "gene_names_uniprotkb": "smad6a; madh6; smad6; wu:fb22g05", "gene_names_refseq": "madh6; smad6a; smad6; wu:fb22g05", "protein_names_uniprotkb": "Mothers against decapentaplegic homolog; MAD homolog; Mothers against DPP homolog; SMAD family member", "protein_names_refseq": "MAD homolog 6; mothers against decapentaplegic homolog 6a", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); craniosynostosis 7 (Disease Ontology:DOID:0060912); aortic valve disease 2 (Disease Ontology:DOID:0080334); nephritis (Disease Ontology:DOID:10952); pulmonary hypertension (Disease Ontology:DOID:6432); radioulnar synostosis (Disease Ontology:DOID:9827)", "pathway": " (dre:116992)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "22247485;22412924;23410941;25564648;26404503;30733552;30837221;32738093;33174840;37086087", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC128793.1, CD753745.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505389 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FP105446.1, FP143687.1, EB834925.1, FP142357.1, EB769633.1 and BC128793.1. On Mar 6, 2009 this sequence version replaced NP_001019981.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070411 I-SMAD binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1N6X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N7Z8-1", "uniprot_id": "A0A8M1N7Z8_DANRE", "mass": 52657.0, "length": 472, "protein_name": "Tubulin beta chain", "gene_name": "tubb2b", "organism": "Zebrafish", "refseq_name": "tubulin beta-2b chain", "refseq_ac": "NP_001032487", "gene_names_uniprotkb": "tubb2b; fb40f09; wu:fb40f09; zgc:123194", "gene_names_refseq": "fb40f09; tubb2b; wu:fb40f09; zgc:123194", "protein_names_uniprotkb": "Tubulin beta chain", "protein_names_refseq": "tubulin beta-2b chain", "tax_id": 7955, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); tubulinopathy (Disease Ontology:DOID:0112227); Leber congenital amaurosis with early-onset deafness (Disease Ontology:DOID:0112240); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (dre:641421)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16109975;24119842;27189481;28026967;29284669;29969449;31908317;32033529;32260203;37024546;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC107976.1, DT880590.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476732 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jun 17, 2015 this sequence version replaced NP_001032487.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1N7Z8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1N9G1-1", "uniprot_id": "A0A8M1N9G1_DANRE", "mass": 88673.0, "length": 774, "protein_name": "carnitine O-palmitoyltransferase", "gene_name": "cpt1aa", "organism": "Zebrafish", "refseq_name": "carnitine palmitoyltransferase 1Aa (liver)", "refseq_ac": "NP_001038319", "gene_names_uniprotkb": "cpt1aa; cpt1a; si:dkey-56p7.8", "gene_names_refseq": "cpt1aa; cpt1a; si:dkey-56p7.8", "protein_names_uniprotkb": "carnitine O-palmitoyltransferase; 2.3.1.21", "protein_names_refseq": "carnitine palmitoyltransferase 1A (liver); carnitine palmitoyltransferase 1Aa (liver)", "tax_id": 7955, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); carnitine palmitoyltransferase I deficiency (Disease Ontology:DOID:0090129); alcoholic hepatitis (Disease Ontology:DOID:12351); lipid metabolism disorder (Disease Ontology:DOID:3146); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:558088); (R-DRE-200425)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "20416398;21481936;21722753;22302940;23201900;37435570;37633055;38474201;39059593;39069827", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.10784845.1, SRR32588729.24740046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476728, SAMEA4476729 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000007.1. On Sep 1, 2006 this sequence version replaced XP_686351.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1U0X8;A0AC58FZ10", "ec_number_list": "2.3.1.21", "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0031998 regulation of fatty acid beta-oxidation;GO:0009437 carnitine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1N9G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NA34-1", "uniprot_id": "A0A8M1NA34_DANRE", "mass": 56379.0, "length": 513, "protein_name": "Palmitoyltransferase", "gene_name": "zdhhc14", "organism": "Zebrafish", "refseq_name": "palmitoyltransferase ZDHHC14", "refseq_ac": "NP_001038652", "gene_names_uniprotkb": "zdhhc14; DHHC-14; si:ch211-199l3.1", "gene_names_refseq": "DHHC-14; si:ch211-199l3.1; zdhhc14", "protein_names_uniprotkb": "Palmitoyltransferase; 2.3.1.225", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 14; palmitoyltransferase ZDHHC14; probable palmitoyltransferase ZDHHC14; zinc finger DHHC domain-containing protein 14; zinc finger DHHC-type containing 14; zinc finger DHHC-type palmitoyltransferase 14", "tax_id": 7955, "disease": "", "pathway": " (dre:569667)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21669877;26056731;26469318;26767746;27235108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.562555.1, GFIL01044021.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On or before Aug 1, 2025 this sequence version replaced XP_005160408.2, NP_001038652.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.225;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M1NA34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NAN4-1", "uniprot_id": "A0A8M1NAN4_DANRE", "mass": 148844.0, "length": 1358, "protein_name": "Vitellogenin 4 precursor", "gene_name": "vtg4", "organism": "Zebrafish", "refseq_name": "vitellogenin 4 precursor", "refseq_ac": "NP_001038759", "gene_names_uniprotkb": "vtg4; si:rp71-23d18.3; wu:fb59b02; wu:fb59d07; wu:fb59e10; zgc:136286; zgc:136383", "gene_names_refseq": "si:rp71-23d18.3; vtg4; wu:fb59b02; wu:fb59d07; wu:fb59e10; zgc:136286; zgc:136383", "protein_names_uniprotkb": "Vitellogenin 4 precursor", "protein_names_refseq": "vg4; vitellogenin 4 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:678536)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11054560;19123940;19174481;19464383;19789858;36708962;37713421;37914813;38660750;39470059;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC129034.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476750, SAMEA4476768 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC115069.1, BF718166.1, EB876279.1, DY556094.1, EB878699.1, EB874546.1, DY546145.1 and AW019833.1. On Nov 17, 2007 this sequence version replaced NP_001038759.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0045735 nutrient reservoir activity", "go_cellular_component": "GO:0032991 protein-containing complex", "go_biological_process": "GO:0032355 response to estradiol;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1NAN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NAV1-1", "uniprot_id": "A0A8M1NAV1_DANRE", "mass": 16654.0, "length": 144, "protein_name": "DNA-directed RNA polymerase III subunit RPC9", "gene_name": "crcp", "organism": "Zebrafish", "refseq_name": "DNA-directed RNA polymerase III subunit RPC9", "refseq_ac": "NP_001038838", "gene_names_uniprotkb": "crcp; rcp9; zgc:153737", "gene_names_refseq": "crcp; rcp9; zgc:153737", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC9; DNA-directed RNA polymerase III subunit rpc9", "protein_names_refseq": "DNA-directed RNA polymerase III subunit RPC9", "tax_id": 7955, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (dre:751656); (R-DRE-76061); (R-DRE-76066); (R-DRE-76071)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "26469318;27151951", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH446153.1, EH585180.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA4476730 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1 and EH585180.1. On Jun 8, 2016 this sequence version replaced NP_001038838.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues., [UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway., [UniProtKB, UniProtKB, UniProtKB]; Rpc9, a component of Pol III, plays an important tissue-specific role in HSPC maintenance during zebrafish embryogenesis and might be conserved across vertebrates, including mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QK38", "ec_number_list": "", "go_molecular_function": "GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006384 transcription initiation at RNA polymerase III promoter;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1NAV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NB85-1", "uniprot_id": "A0A8M1NB85_DANRE", "mass": 83773.0, "length": 733, "protein_name": "2.7.10.1; Non-receptor tyrosine-protein kinase TNK1", "gene_name": "tnk1", "organism": "Zebrafish", "refseq_name": "non-receptor tyrosine-protein kinase TNK1", "refseq_ac": "NP_001073486", "gene_names_uniprotkb": "tnk1; ack1; ackb; tnk2b; tnk2; wu:fj16g04; zgc:154019", "gene_names_refseq": "ack1; ackb; tnk1; tnk2b; tnk2; wu:fj16g04; zgc:154019", "protein_names_uniprotkb": "2.7.10.1; Non-receptor tyrosine-protein kinase TNK1", "protein_names_refseq": "activated Cdc42-associated kinase 1; non-receptor tyrosine-protein kinase TNK1; tyrosine kinase, non-receptor, 2b; tyrosine kinase, non-receptor, 2", "tax_id": 7955, "disease": "", "pathway": " (dre:565029)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11116086;15520368;16109975;19482995;23234507;26469318;27189481;33253749", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC125935.1, SRR26395039.1989994.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Jun 25, 2025 this sequence version replaced NP_001073486.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QB24", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.11.12;2.7.11.39;2.7.11.11;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M1NB85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NCY5-1", "uniprot_id": "A0A8M1NCY5_DANRE", "mass": 34976.0, "length": 314, "protein_name": "mRNA decay activator protein ZFP36", "gene_name": "wu:fi61b04", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC564559", "refseq_ac": "NP_001082873", "gene_names_uniprotkb": "wu:fi61b04; fi61b04; zgc:162730", "gene_names_refseq": "fi61b04; wu:fi61b04; zgc:162730", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36; Zinc finger protein 36", "protein_names_refseq": "uncharacterized protein LOC564559", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dre:564559)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27189481;27503704", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC139894.1, CK027670.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC139894.1. On or before Jun 17, 2015 this sequence version replaced XP_009289816.1, NP_001082873.1., [RefSeq]; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008270 zinc ion binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0160134 protein-RNA sequence-specific adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1NCY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NDU0-1", "uniprot_id": "A0A8M1NDU0_DANRE", "mass": 35303.0, "length": 317, "protein_name": "Peroxisomal membrane protein PMP34", "gene_name": "slc25a17", "organism": "Zebrafish", "refseq_name": "peroxisomal membrane protein PMP34 isoform 1", "refseq_ac": "NP_001092731", "gene_names_uniprotkb": "slc25a17; si:dkey-68o6.9; zgc:162641", "gene_names_refseq": "si:dkey-68o6.9; slc25a17; zgc:162641", "protein_names_uniprotkb": "Peroxisomal membrane protein PMP34", "protein_names_refseq": "peroxisomal membrane protein PMP34 isoform 1; peroxisomal membrane protein PMP34-like; peroxisomal membrane protein), member 17; peroxisomal membrane protein, 34kDa), member 17; solute carrier family 25 (mitochondrial carrier", "tax_id": 7955, "disease": "", "pathway": " (dre:100093708)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "27086301;27189481;31187491;35295584;36270274", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01002254.1, SRR26395012.876297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476738, SAMEA4476770 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1 and BC139873.1. On Jun 11, 2015 this sequence version replaced NP_001092731.1. Sequence Note:., [RefSeq]; Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity;GO:0044610 FMN transmembrane transporter activity;GO:0051724 NAD transmembrane transporter activity", "go_cellular_component": "GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0048794 swim bladder development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M1NDU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NEC2-1", "uniprot_id": "A0A8M1NEC2_DANRE", "mass": 71920.0, "length": 635, "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "gene_name": "inpp5e", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol polyphosphate 5-phosphatase type IV", "refseq_ac": "NP_001096089", "gene_names_uniprotkb": "inpp5e; Innpp5e; im:7152772; zgc:165612", "gene_names_refseq": "Innpp5e; im:7152772; inpp5e; zgc:165612", "protein_names_uniprotkb": "Phosphatidylinositol polyphosphate 5-phosphatase type IV; 3.1.3.36; 3.1.3.86; 72 kDa inositol polyphosphate 5-phosphatase; Inositol polyphosphate-5-phosphatase E; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "protein_names_refseq": "phosphatidylinositol polyphosphate 5-phosphatase type IV", "tax_id": 7955, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); Joubert syndrome 1 (Disease Ontology:DOID:0110980); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:606579)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23022135;27401686;39400299", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588723.962948.1, SRR32588718.10317621.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On or before Jan 27, 2011 this sequence version replaced XP_002662227.1, NP_001096089.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JKW6", "ec_number_list": "3.1.3.86;3.1.3.56;3.1.3.36", "go_molecular_function": "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005930 axoneme;GO:0005929 cilium", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0060271 cilium assembly;GO:0032402 melanosome transport;GO:1902017 regulation of cilium assembly;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1NEC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NFU6-1", "uniprot_id": "A0A8M1NFU6_DANRE", "mass": 45777.0, "length": 402, "protein_name": "Alpha-1,3/1,6-mannosyltransferase ALG2", "gene_name": "alg2", "organism": "Zebrafish", "refseq_name": "alpha-1,3/1,6-mannosyltransferase ALG2", "refseq_ac": "NP_001098406", "gene_names_uniprotkb": "alg2; im:7145131", "gene_names_refseq": "alg2; im:7145131", "protein_names_uniprotkb": "Alpha-1,3/1,6-mannosyltransferase ALG2; 2.4.1.132; 2.4.1.257; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase", "protein_names_refseq": "alpha-1,3/1,6-mannosyltransferase ALG2; asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)", "tax_id": 7955, "disease": "congenital disorder of glycosylation Ii (Disease Ontology:DOID:0080561); congenital myasthenic syndrome 14 (Disease Ontology:DOID:0110669)", "pathway": " (dre:403068)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;17045351;26469318;26912795;28252024;33273096", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC152225.1, GDQQ01015093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Oct 19, 2010 this sequence version replaced NP_001098406.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.132;2.4.1.257", "go_molecular_function": "GO:0004378 GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity;GO:0102704 GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M1NFU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P999-1", "uniprot_id": "A0A8M1P999_DANRE", "mass": 94317.0, "length": 842, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "sik2a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase SIK2a isoform 1", "refseq_ac": "NP_001314873", "gene_names_uniprotkb": "sik2a; si:dkey-27p23.1; snf1lk2a", "gene_names_refseq": "si:dkey-27p23.1; sik2a; snf1lk2a", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "SNF1-like kinase 2a; serine/threonine-protein kinase SIK2a isoform 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100126142)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12477932;21873635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01037993.1, ERR6511330.704155.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 17, 2025 this sequence version replaced NP_001314873.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PN50", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1P999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NGF4-1", "uniprot_id": "A0A8M1NGF4_DANRE", "mass": 76164.0, "length": 684, "protein_name": "3.4.21.104; Mannan-binding lectin serine protease 2 precursor", "gene_name": "masp2", "organism": "Zebrafish", "refseq_name": "mannan-binding lectin serine protease 2 precursor", "refseq_ac": "NP_001116330", "gene_names_uniprotkb": "masp2; sb:eu714; wu:fb62a09", "gene_names_refseq": "masp2; sb:eu714; wu:fb62a09", "protein_names_uniprotkb": "3.4.21.104; Mannan-binding lectin serine protease 2 precursor", "protein_names_refseq": "mannan-binding lectin serine peptidase 2; mannan-binding lectin serine protease 2 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:560277)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19200601;26469318;27189481;27215328;31043432;31468037;33160183", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046065.1, GFIL01025972.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000023.1. On Jun 7, 2025 this sequence version replaced NP_001116330.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0006956 complement activation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M1NGF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NGN8-1", "uniprot_id": "A0A8M1NGN8_DANRE", "mass": 113671.0, "length": 985, "protein_name": "Kinesin-like protein", "gene_name": "kif5c", "organism": "Zebrafish", "refseq_name": "kinesin heavy chain", "refseq_ac": "NP_001116747", "gene_names_uniprotkb": "kif5c; si:ch211-157c24.3", "gene_names_refseq": "kif5c; si:ch211-157c24.3", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin heavy chain", "tax_id": 7955, "disease": "complex cortical dysplasia with other brain malformations 2 (Disease Ontology:DOID:0090133); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); spinal muscular atrophy (Disease Ontology:DOID:12377); leiomyoma (Disease Ontology:DOID:127); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); hereditary spastic paraplegia (Disease Ontology:DOID:2476); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:565563)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "23684767;25355224;26469318;27189481;28252024;29344929;30929901;32668451;35929537", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588725.23699175.1, SRR32588717.36311825.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Apr 11, 2008 this sequence version replaced XP_693931.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S8J1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0007411 axon guidance;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1NGN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NHC5-1", "uniprot_id": "A0A8M1NHC5_DANRE", "mass": 62182.0, "length": 540, "protein_name": "Hexosyltransferase", "gene_name": "csgalnact2", "organism": "Zebrafish", "refseq_name": "chondroitin sulfate N-acetylgalactosaminyltransferase 2", "refseq_ac": "NP_001119869", "gene_names_uniprotkb": "csgalnact2; mp:zf637-2-001473; si:dkey-192p21.4; wu:fb98d03", "gene_names_refseq": "csgalnact2; mp:zf637-2-001473; si:dkey-192p21.4; wu:fb98d03", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "chondroitin sulfate N-acetylgalactosaminyltransferase 2; zf637-2-001473", "tax_id": 7955, "disease": "", "pathway": " (dre:560826); (R-DRE-2022870)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16109975;22869369;23703795;26469318;27189481;35192612", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01007344.1, SRR26395017.247067.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. On Jul 31, 2008 this sequence version replaced XP_685862.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H155;A8E7C8", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M1NHC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NHZ0-1", "uniprot_id": "A0A8M1NHZ0_DANRE", "mass": 98191.0, "length": 868, "protein_name": "Dipeptidyl-peptidase 6", "gene_name": "dpp6b", "organism": "Zebrafish", "refseq_name": "dipeptidyl-peptidase 6", "refseq_ac": "NP_001108594", "gene_names_uniprotkb": "dpp6b; dpp6", "gene_names_refseq": "dpp6", "protein_names_uniprotkb": "Dipeptidyl-peptidase 6", "protein_names_refseq": "dipeptidyl-peptidase 6", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); spinal muscular atrophy (Disease Ontology:DOID:12377); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (dre:566832)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX547997.9, CT030720.8 and BX005226.10. On Mar 5, 2008 this sequence version replaced XP_001341154.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1NHZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NIE6-1", "uniprot_id": "A0A8M1NIE6_DANRE", "mass": 89594.0, "length": 779, "protein_name": "IkappaB kinase", "gene_name": "ikbkb", "organism": "Zebrafish", "refseq_name": "inhibitor of nuclear factor kappa-B kinase subunit beta", "refseq_ac": "NP_001116737", "gene_names_uniprotkb": "ikbkb; ikk2", "gene_names_refseq": "ikbkb; ikk2", "protein_names_uniprotkb": "IkappaB kinase; 2.7.11.10", "protein_names_refseq": "Ikkb; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta", "tax_id": 7955, "disease": "colitis (Disease Ontology:DOID:0060180); immunodeficiency 15B (Disease Ontology:DOID:0111959); immunodeficiency 15A (Disease Ontology:DOID:0111960); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); prostate adenocarcinoma (Disease Ontology:DOID:2526); dermatitis (Disease Ontology:DOID:2723); liver cancer (Disease Ontology:DOID:3571); pneumonia (Disease Ontology:DOID:552); muscular atrophy (Disease Ontology:DOID:767); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:563560); (R-DRE-1169091); (R-DRE-209543); (R-DRE-209560); (R-DRE-445989); (R-DRE-5357905); (R-DRE-5684264); (R-DRE-9020702); (R-DRE-937039); (R-DRE-975144); (R-DRE-9758274); (R-DRE-9833482)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "18039395;19723885;20047469;26469318;27189481;33476306;35806111;37590563;38152479;39141879", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.21146038.1, SRR32588719.5455002.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMEA708836 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Apr 11, 2008 this sequence version replaced XP_692018.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0R199", "ec_number_list": "2.3.2.27;2.7.11.10;2.7.11.25", "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043588 skin development;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NIE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NIG0-1", "uniprot_id": "A0A8M1NIG0_DANRE", "mass": 93790.0, "length": 810, "protein_name": "Outer dense fiber protein 2", "gene_name": "odf2b", "organism": "Zebrafish", "refseq_name": "outer dense fiber protein 2b", "refseq_ac": "NP_001116704", "gene_names_uniprotkb": "odf2b; im:7137744; si:ch211-251j10.4; wu:fc04b05", "gene_names_refseq": "im:7137744; odf2b; si:ch211-251j10.4; wu:fc04b05", "protein_names_uniprotkb": "Outer dense fiber protein 2; Cenexin; Outer dense fiber of sperm tails protein 2", "protein_names_refseq": "outer dense fiber of sperm tails 2-like; outer dense fiber protein 2b", "tax_id": 7955, "disease": "", "pathway": " (dre:449859)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.1166836.1, SRR26395017.341533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898401, SAMEA898403 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jun 25, 2025 this sequence version replaced NP_001116704.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S753;F1QT36", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005814 centriole", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M1NIG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NJX9-1", "uniprot_id": "A0A8M1NJX9_DANRE", "mass": 87604.0, "length": 775, "protein_name": "Semaphorin-3B", "gene_name": "sema3b", "organism": "Zebrafish", "refseq_name": "semaphorin-3B precursor", "refseq_ac": "NP_001121818", "gene_names_uniprotkb": "sema3b; si:ch211-106g4.2", "gene_names_refseq": "sema3b; si:ch211-106g4.2", "protein_names_uniprotkb": "Semaphorin-3B", "protein_names_refseq": "semaphorin 3B; semaphorin-3B precursor", "tax_id": 7955, "disease": "substance abuse (Disease Ontology:DOID:302)", "pathway": " (dre:567064)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30661757;31349972;32851162", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01006821.1, SRR32588729.11909572.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jun 18, 2009 this sequence version replaced XP_695446.3., [RefSeq]; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G7W8;A0AC58G7X0;A0AC58G7X7;M9MM94", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0072359 circulatory system development;GO:0035295 tube development;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1NJX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NRP3-1", "uniprot_id": "A0A8M1NRP3_DANRE", "mass": 52908.0, "length": 470, "protein_name": "Peroxisome proliferator-activated receptor alpha", "gene_name": "pparaa", "organism": "Zebrafish", "refseq_name": "peroxisome proliferator-activated receptor alpha a", "refseq_ac": "NP_001154805", "gene_names_uniprotkb": "pparaa; ppara3; si:ch211-239e6.3", "gene_names_refseq": "ppara3; pparaa; si:ch211-239e6.3", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1", "protein_names_refseq": "NR1C1-A; PPAR[a](III); PPARalpha-A; nr1c1a; peroxisome proliferator activated receptor alpha 3; peroxisome proliferator-activated receptor alpha a; ppara2; ppara", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); morbid obesity (Disease Ontology:DOID:11981); alcoholic hepatitis (Disease Ontology:DOID:12351); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); coronary artery disease (Disease Ontology:DOID:3393); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); diabetes mellitus (Disease Ontology:DOID:9351); hypertensive encephalopathy (Disease Ontology:DOID:9427); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:563298)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;17256142;17997606;20932299;38788853;39059593;39069827;39075492;39216301;9192646", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.38939530.1, SRR32588715.702258.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505383 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On May 29, 2009 this sequence version replaced XP_691755.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J7G3;A0AC58J7G4;A0AC58J7G6;A0AC58J7G8;A0AC58J7G9;A0AC58J7H0;A0AC58J7H1;A0AC58J7H2;A0AC58J7H3;A0AC58J7H4;A0AC58J7H5;A0AC58J7H6;A0AC58J7H7;A0AC58J7H8;A0AC58J7I1;A0AC58J7I5;A0AC58J7I7;A0AC58J7J2;A0AC58J7J5;F1Q684;Q5RGZ2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008289 lipid binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006631 fatty acid metabolic process;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NRP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NSE3-1", "uniprot_id": "A0A8M1NSE3_DANRE", "mass": 98054.0, "length": 872, "protein_name": "Aminopeptidase", "gene_name": "npepps", "organism": "Zebrafish", "refseq_name": "puromycin-sensitive aminopeptidase", "refseq_ac": "NP_001157499", "gene_names_uniprotkb": "npepps; Psa; fb68d07; psa; sb:cb848; sb:eu910; wu:fb68d07", "gene_names_refseq": "Psa; fb68d07; npepps; psa; sb:cb848; sb:eu910; wu:fb68d07", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "puromycin-sensitive aminopeptidase", "tax_id": 7955, "disease": "", "pathway": " (dre:407726)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;21276865;24198278;25504979;28252024;33914736", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01018486.1, GDQH01002452.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505380 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Aug 10, 2009 this sequence version replaced XP_684042.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; The purification and characterization of a puromycin-sensitive aminopeptidase from zebrafish Erratum:[Comp Biochem Physiol B Biochem Mol Biol. 2011 Jul;159(3):190], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0016285 alanyl aminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M1NSE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NSW5-1", "uniprot_id": "A0A8M1NSW5_DANRE", "mass": 33558.0, "length": 304, "protein_name": "Carbonic anhydrase", "gene_name": "ca4b", "organism": "Zebrafish", "refseq_name": "carbonic anhydrase 4b precursor", "refseq_ac": "NP_001159683", "gene_names_uniprotkb": "ca4b", "gene_names_refseq": "ca4b", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "ca4d; carbonic anhydrase 4b precursor", "tax_id": 7955, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:553246)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18322140;23565095;24990885;27188255;27189481;34617657", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078387.1, BC109405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078387.1., [RefSeq]; Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid., [UniProtKB, UniProtKB, UniProtKB]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M1NSW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NTE7-1", "uniprot_id": "A0A8M1NTE7_DANRE", "mass": 143942.0, "length": 1491, "protein_name": "Collagen, type V, alpha 2a precursor", "gene_name": "col5a2a", "organism": "Zebrafish", "refseq_name": "collagen, type V, alpha 2a precursor", "refseq_ac": "NP_001139254", "gene_names_uniprotkb": "col5a2a; COL5A2; col5a2l; im:7038599; si:by143e18.1; si:ch211-198b21.5; si:dz167c3.3; wu:fa13f03; wu:fa98d01; wu:fj05e03", "gene_names_refseq": "COL5A2; col5a2a; col5a2l; im:7038599; si:by143e18.1; si:ch211-198b21.5; si:dz167c3.3; wu:fa13f03; wu:fa98d01; wu:fj05e03", "protein_names_uniprotkb": "Collagen, type V, alpha 2a precursor", "protein_names_refseq": "collagen, type V, alpha 2a precursor", "tax_id": 7955, "disease": "Ehlers-Danlos syndrome classic type 2 (Disease Ontology:DOID:0080726); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); Ehlers-Danlos syndrome classic type 1 (Disease Ontology:DOID:14720); lung disease (Disease Ontology:DOID:850)", "pathway": " (dre:564821)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21191402;24815885;25420467;25831505;26256560;34026760;34943942;35052463;35525365;35782869;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01004480.1, GDQH01006660.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Mar 11, 2009 this sequence version replaced XP_693243.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005588 collagen type V trimer", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1NTE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NUS6-1", "uniprot_id": "A0A8M1NUS6_DANRE", "mass": 154176.0, "length": 1380, "protein_name": "Condensin complex subunit 1", "gene_name": "ncapd2", "organism": "Zebrafish", "refseq_name": "condensin complex subunit 1", "refseq_ac": "NP_001155974", "gene_names_uniprotkb": "ncapd2; im:6902697; si:dkey-175g20.1; wu:fc13f08; wu:fx06e10", "gene_names_refseq": "im:6902697; ncapd2; si:dkey-175g20.1; wu:fc13f08; wu:fx06e10", "protein_names_uniprotkb": "Condensin complex subunit 1", "protein_names_refseq": "cap-d2; condensin complex subunit 1", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 21 (Disease Ontology:DOID:0051032)", "pathway": " (dre:552978); (R-DRE-2514853)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "19586528;24198278;24813897;25504979;26469318;28803829;33785593;35641933;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133123.1, GDQH01008157.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Jun 10, 2025 this sequence version replaced NP_001155974.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Loss of the interaction partners CAP-H and CAP-D2 causes cytoplasmic mislocalization of CAP-G throughout mitosis. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0V123", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000796 condensin complex;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0010032 meiotic chromosome condensation;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A8M1NUS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NV26-1", "uniprot_id": "A0A8M1NV26_DANRE", "mass": 71425.0, "length": 629, "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "raf1b", "organism": "Zebrafish", "refseq_name": "RAF proto-oncogene serine/threonine-protein kinase", "refseq_ac": "NP_001186684", "gene_names_uniprotkb": "raf1b", "gene_names_refseq": "raf1b", "protein_names_uniprotkb": "RAF proto-oncogene serine/threonine-protein kinase; 2.7.11.1; Raf-1", "protein_names_refseq": "RAF proto-oncogene serine/threonine-protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1b", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); Noonan syndrome 5 (Disease Ontology:DOID:0060583); Noonan syndrome with multiple lentigines 2 (Disease Ontology:DOID:0080549); dilated cardiomyopathy 1NN (Disease Ontology:DOID:0110432); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); Noonan syndrome (Disease Ontology:DOID:3490); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); pancreatic carcinoma (Disease Ontology:DOID:4905)", "pathway": " (dre:557109)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19500364;24069208;25239370;26469318;27189481;33279959;39347412;39452847;39496611", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001700.1, SRR32588724.930425.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000011.1 and BC097130.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4I9V9;A0AC58GQJ7;F1QRN2", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1NV26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NVN2-1", "uniprot_id": "A0A8M1NVN2_DANRE", "mass": 25818.0, "length": 222, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "hacd4", "organism": "Zebrafish", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4", "refseq_ac": "NP_001186940", "gene_names_uniprotkb": "hacd4; fc47e05; ptplad2; si:ch73-41h24.1; wu:fc47e05", "gene_names_refseq": "fc47e05; hacd4; ptplad2; si:ch73-41h24.1; wu:fc47e05", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; 4.2.1.134", "protein_names_refseq": "protein tyrosine phosphatase-like A domain containing 2-like; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4", "tax_id": 7955, "disease": "", "pathway": " (dre:561303); (R-DRE-75876)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "27189481;35429189;39528516", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115174.1, CN015658.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Nov 18, 2014 this sequence version replaced NP_001186940.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IHH3", "ec_number_list": "4.2.1.134", "go_molecular_function": "GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1NVN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NVX4-1", "uniprot_id": "A0A8M1NVX4_DANRE", "mass": 63197.0, "length": 564, "protein_name": "Diacylglycerol kinase", "gene_name": "dgke", "organism": "Zebrafish", "refseq_name": "diacylglycerol kinase epsilon", "refseq_ac": "NP_001165699", "gene_names_uniprotkb": "dgke", "gene_names_refseq": "dgke", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase epsilon", "tax_id": 7955, "disease": "nephrotic syndrome type 7 (Disease Ontology:DOID:0080388)", "pathway": " (dre:100150463)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01017424.1, GDQH01012090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476735 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000006.1. On May 20, 2010 this sequence version replaced XP_001920687.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.107;2.7.1.94;2.7.1.138", "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046474 glycerophospholipid biosynthetic process;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0046486 glycerolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M1NVX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NWF7-1", "uniprot_id": "A0A8M1NWF7_DANRE", "mass": 82898.0, "length": 730, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "tlk1a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase tousled-like 1", "refseq_ac": "NP_001186653", "gene_names_uniprotkb": "tlk1a; fb76h12; fc17f07; si:dkey-88m1.1; tlk1; wu:fb76h12; wu:fc17f07", "gene_names_refseq": "fb76h12; fc17f07; si:dkey-88m1.1; tlk1a; tlk1; wu:fb76h12; wu:fc17f07", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase tousled-like 1; tousled-like kinase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:557765)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588723.2538088.1, SRR32588727.3174392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Dec 15, 2010 this sequence version replaced XP_001922901.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A5H2", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007059 chromosome segregation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1NWF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NXI0-1", "uniprot_id": "A0A8M1NXI0_DANRE", "mass": 54979.0, "length": 494, "protein_name": "Protein disulfide-isomerase", "gene_name": "pdia3", "organism": "Zebrafish", "refseq_name": "protein disulfide-isomerase A3 precursor", "refseq_ac": "NP_001186666", "gene_names_uniprotkb": "pdia3; Grp58; erp57; sb:cb825", "gene_names_refseq": "Grp58; erp57; pdia3; sb:cb825", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1", "protein_names_refseq": "glucose regulated protein; protein disulfide-isomerase A3 precursor", "tax_id": 7955, "disease": "asphyxia neonatorum (Disease Ontology:DOID:11088); autoimmune hepatitis (Disease Ontology:DOID:2048); post-traumatic stress disorder (Disease Ontology:DOID:2055); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (dre:378851)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18258299;20528263;23615277;23873374;23939298;26227973;28005350;29471808;33271625;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001087.1, GDQQ01004929.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1, EB857174.1 and EH533119.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0042470 melanosome", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A0A8M1NXI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NXK7-1", "uniprot_id": "A0A8M1NXK7_DANRE", "mass": 30056.0, "length": 273, "protein_name": "Eukaryotic translation initiation factor 3 subunit F", "gene_name": "eif3f", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit F", "refseq_ac": "NP_001186938", "gene_names_uniprotkb": "eif3f; EIF3F; EIF3S5; si:dkey-58j19.2", "gene_names_refseq": "eif3f; si:dkey-58j19.2", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF3f", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit F", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 67 (Disease Ontology:DOID:0081228); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:557270)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20040115;26469318;27189481;28252024;28450118;31053140;40044042", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0003743 translation initiation factor activity;GO:0101005 deubiquitinase activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1NXK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1NYZ0-1", "uniprot_id": "A0A8M1NYZ0_DANRE", "mass": 52575.0, "length": 460, "protein_name": "Angiopoietin-related protein 4 precursor", "gene_name": "angptl4", "organism": "Zebrafish", "refseq_name": "angiopoietin-related protein 4 precursor", "refseq_ac": "NP_001243132", "gene_names_uniprotkb": "angptl4; fiaf; im:7144703; si:rp71-39b20.7", "gene_names_refseq": "angptl4; fiaf; im:7144703; si:rp71-39b20.7", "protein_names_uniprotkb": "Angiopoietin-related protein 4 precursor", "protein_names_refseq": "angiopoietin-like 4 protein; angiopoietin-related protein 4 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:492647)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21439961;22479192;26469318;27834691;28385711;36614116;37094155;37201426;37332366;37690345", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01001027.1, GDQQ01005546.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Jan 14, 2012 this sequence version replaced XP_692048.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish., [RefSeq, PubMed]; These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007596 blood coagulation;GO:0009617 response to bacterium;GO:0070328 triglyceride homeostasis;GO:1902262 apoptotic process involved in blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1NYZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P3D7-1", "uniprot_id": "A0A8M1P3D7_DANRE", "mass": 31729.0, "length": 271, "protein_name": "Histone RNA hairpin-binding protein isoform 1", "gene_name": "slbp", "organism": "Zebrafish", "refseq_name": "histone RNA hairpin-binding protein isoform 1", "refseq_ac": "NP_001243122", "gene_names_uniprotkb": "slbp; cb157; ele; sb:cb157; si:dkey-102m7.2; slbp1", "gene_names_refseq": "cb157; ele; sb:cb157; si:dkey-102m7.2; slbp1; slbp", "protein_names_uniprotkb": "Histone RNA hairpin-binding protein isoform 1", "protein_names_refseq": "histone RNA hairpin-binding protein isoform 1; stem-loop binding protein", "tax_id": 7955, "disease": "", "pathway": " (dre:407727)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "23804756;24926785;30695021;32267837;34872632;36417881;9007226;9007241;9007259", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01019661.1, GFIL01038204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH496507.1, EH578014.1 and JBMGRA010000014.1. On or before Jan 12, 2012 this sequence version replaced XP_697717.3, XP_002664392.1. Transcript Variant: This variant represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0071207 histone pre-mRNA stem-loop binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0003407 neural retina development;GO:0030182 neuron differentiation;GO:0048854 brain morphogenesis;GO:0031290 retinal ganglion cell axon guidance;GO:0046530 photoreceptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1P3D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P258-1", "uniprot_id": "A0A8M1P258_DANRE", "mass": 17716.0, "length": 158, "protein_name": "Low molecular weight phosphotyrosine protein phosphatase", "gene_name": "acp1", "organism": "Zebrafish", "refseq_name": "low molecular weight phosphotyrosine protein phosphatase isoform 2", "refseq_ac": "NP_001231711", "gene_names_uniprotkb": "acp1; im:6910498; zgc:110844", "gene_names_refseq": "acp1; im:6910498; zgc:110844", "protein_names_uniprotkb": "Low molecular weight phosphotyrosine protein phosphatase; 3.1.3.2; 3.1.3.48; LMW-PTPase; LMW-PTP; Low molecular weight cytosolic acid phosphatase", "protein_names_refseq": "acid phosphatase 1, soluble; low molecular weight phosphotyrosine protein phosphatase isoform 2", "tax_id": 7955, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); coronary artery disease (Disease Ontology:DOID:3393); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:541489)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "26469318;27189481;27920155;28252024;28502661;36403304", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.662406.1, CT697743.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Transcript Variant: This variant (2) lacks a coding exon and includes an alternate coding exon compared to variant 1. The resulting protein (isoform 2) is the same length and has the same N- and C-termini compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IBG2", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.1;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048793 pronephros development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M1P258-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P3C1-1", "uniprot_id": "A0A8M1P3C1_DANRE", "mass": 59617.0, "length": 534, "protein_name": "Telomerase Cajal body protein 1", "gene_name": "wrap53", "organism": "Zebrafish", "refseq_name": "telomerase Cajal body protein 1", "refseq_ac": "NP_001242957", "gene_names_uniprotkb": "wrap53; fb34f12; fi26g08; wu:fb34f12; wu:fi26g08", "gene_names_refseq": "fb34f12; fi26g08; wrap53; wu:fb34f12; wu:fi26g08", "protein_names_uniprotkb": "Telomerase Cajal body protein 1; WD repeat-containing protein 79", "protein_names_refseq": "WD repeat domain 79; telomerase Cajal body protein 1", "tax_id": 7955, "disease": "autosomal recessive dyskeratosis congenita 3 (Disease Ontology:DOID:0070019); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); glottis squamous cell carcinoma (Disease Ontology:DOID:7031); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:321796); (R-DRE-171319); (R-DRE-174430)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001645.1, GDQQ01025500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Dec 24, 2011 this sequence version replaced XP_003198985.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F3D5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0015030 Cajal body", "go_biological_process": "GO:0030576 Cajal body organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M1P3C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P3E9-1", "uniprot_id": "A0A8M1P3E9_DANRE", "mass": 55699.0, "length": 515, "protein_name": "Synaptic vesicular amine transporter", "gene_name": "slc18a2", "organism": "Zebrafish", "refseq_name": "synaptic vesicular amine transporter", "refseq_ac": "NP_001243154", "gene_names_uniprotkb": "slc18a2", "gene_names_refseq": "slc18a2", "protein_names_uniprotkb": "Synaptic vesicular amine transporter", "protein_names_refseq": "solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; synaptic vesicular amine transporter; vmat2", "tax_id": 7955, "disease": "infantile parkinsonism-dystonia 2 (Disease Ontology:DOID:0070490); Parkinson's disease (Disease Ontology:DOID:14330); Machado-Joseph disease (Disease Ontology:DOID:1440); anxiety disorder (Disease Ontology:DOID:2030); substance-related disorder (Disease Ontology:DOID:303); toxic encephalopathy (Disease Ontology:DOID:3602); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:553304)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18164283;19697161;20123022;21192085;21276790;36936688;37603776;37688406;38416162;38579950", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC090766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476810, SAMEA898404 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC090766.1. On Jan 14, 2012 this sequence version replaced XP_002665236.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005335 serotonin:sodium:chloride symporter activity", "go_cellular_component": "GO:0043195 terminal bouton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0001964 startle response;GO:0007420 brain development;GO:0030431 sleep;GO:0036269 swimming behavior;GO:1904338 regulation of dopaminergic neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P3E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P3F9-1", "uniprot_id": "A0A8M1P3F9_DANRE", "mass": 139864.0, "length": 1270, "protein_name": "RNA helicase", "gene_name": "dhx9", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase A", "refseq_ac": "NP_001188373", "gene_names_uniprotkb": "dhx9; si:ch211-194i4.1; wu:fe02c10", "gene_names_refseq": "dhx9; si:ch211-194i4.1; wu:fe02c10", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13; DEAH box protein 9; Nuclear DNA helicase II", "protein_names_refseq": "ATP-dependent RNA helicase A; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box helicase 9", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 75 (Disease Ontology:DOID:0061048); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:568043)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21246659;25972544;26469318;28252024;32526283;33242567;36142434;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC058323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058323.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009615 response to virus;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P3F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P4D1-1", "uniprot_id": "A0A8M1P4D1_DANRE", "mass": 37684.0, "length": 348, "protein_name": "Prostaglandin reductase 2", "gene_name": "ptgr2", "organism": "Zebrafish", "refseq_name": "prostaglandin reductase 2", "refseq_ac": "NP_001243152", "gene_names_uniprotkb": "ptgr2; im:6903726; si:dkey-119a7.6", "gene_names_refseq": "im:6903726; ptgr2; si:dkey-119a7.6", "protein_names_uniprotkb": "Prostaglandin reductase 2; 1.3.1.48; 15-oxoprostaglandin 13-reductase", "protein_names_refseq": "prostaglandin reductase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:553234)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC077125.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476745, SAMEA4476753 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC077125.1. On Jan 14, 2012 this sequence version replaced XP_001923766.1., [RefSeq]; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.48;1.3.1.74", "go_molecular_function": "GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006693 prostaglandin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1P4D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P4H4-1", "uniprot_id": "A0A8M1P4H4_DANRE", "mass": 98994.0, "length": 893, "protein_name": "1.11.1.7; Eosinophil peroxidase isoform 1 precursor", "gene_name": "mpx", "organism": "Zebrafish", "refseq_name": "eosinophil peroxidase isoform 1 precursor", "refseq_ac": "NP_001338766", "gene_names_uniprotkb": "mpx; drf; fj80f04; mpo; wu:fj80f04", "gene_names_refseq": "drf; fj80f04; mpo; mpx; wu:fj80f04", "protein_names_uniprotkb": "1.11.1.7; Eosinophil peroxidase isoform 1 precursor", "protein_names_refseq": "eosinophil peroxidase isoform 1 precursor; myeloperoxidase; unm t30963; unm_sm681; unm_t30963", "tax_id": 7955, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); keratosis (Disease Ontology:DOID:161); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); bacterial pneumonia (Disease Ontology:DOID:874); status asthmaticus (Disease Ontology:DOID:9362); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (dre:337514)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11468162;11698295;14996705;15070763;15520368;39114912;39138265;39242546;39558430;39584740", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056287.1, GFIL01026798.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0140825 lactoperoxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0006979 response to oxidative stress;GO:0009617 response to bacterium;GO:0010310 regulation of hydrogen peroxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P4H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P4I3-1", "uniprot_id": "A0A8M1P4I3_DANRE", "mass": 52797.0, "length": 486, "protein_name": "Wiskott-Aldrich syndrome protein family member", "gene_name": "wasf2", "organism": "Zebrafish", "refseq_name": "actin-binding protein WASF2", "refseq_ac": "NP_001315119", "gene_names_uniprotkb": "wasf2; zgc:56010", "gene_names_refseq": "wasf2; zgc:56010", "protein_names_uniprotkb": "Wiskott-Aldrich syndrome protein family member; WASP family protein member", "protein_names_refseq": "WAS protein family, member 2; actin-binding protein WASF2", "tax_id": 7955, "disease": "", "pathway": " (dre:394056); (R-DRE-2029482); (R-DRE-5663213); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013423)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "22411201;26469318;28252024;32368696;35709765;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395050.1000996.1, SRR26395063.958184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LVV3", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0031209 SCAR complex", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M1P4I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P4R1-1", "uniprot_id": "A0A8M1P4R1_DANRE", "mass": 87753.0, "length": 780, "protein_name": "4'-phosphopantetheine phosphatase", "gene_name": "pank4", "organism": "Zebrafish", "refseq_name": "4'-phosphopantetheine phosphatase", "refseq_ac": "NP_001315316", "gene_names_uniprotkb": "pank4; zgc:66285", "gene_names_refseq": "pank4; zgc:66285", "protein_names_uniprotkb": "4'-phosphopantetheine phosphatase; Inactive pantothenic acid kinase 4", "protein_names_refseq": "4'-phosphopantetheine phosphatase", "tax_id": 7955, "disease": "pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); cataract (Disease Ontology:DOID:83)", "pathway": " (dre:393487)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22265871;26476142;27189481", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On Jun 16, 2016 this sequence version replaced XP_009304203.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016791 phosphatase activity;GO:0016787 hydrolase activity;GO:0004594 pantothenate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1P4R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P5M7-1", "uniprot_id": "A0A8M1P5M7_DANRE", "mass": 18276.0, "length": 183, "protein_name": "Bone Gla protein", "gene_name": "bglapl", "organism": "Zebrafish", "refseq_name": "bone gamma-carboxyglutamate (gla) protein, like precursor", "refseq_ac": "NP_001278818", "gene_names_uniprotkb": "bglapl; OC2; hm:zehn0597; zehn0597", "gene_names_refseq": "OC2; bglapl; hm:zehn0597; zehn0597", "protein_names_uniprotkb": "Bone Gla protein; Gamma-carboxyglutamic acid-containing protein", "protein_names_refseq": "bone gamma-carboxyglutamate (gla) protein, like precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:337724)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16565091;23043290;28380670;29940513;31238190;31636113;35993337;36500990;36680903;37777592", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588734.1389028.1, EG565903.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jun 7, 2025 this sequence version replaced NP_001278818.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:0060348 bone development;GO:0031214 biomineral tissue development;GO:0001649 osteoblast differentiation;GO:0032571 response to vitamin K", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P5M7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P669-1", "uniprot_id": "A0A8M1P669_DANRE", "mass": 79892.0, "length": 720, "protein_name": "3.5.4.4; Double-stranded RNA-specific editase 1a", "gene_name": "adarb1a", "organism": "Zebrafish", "refseq_name": "double-stranded RNA-specific editase 1a", "refseq_ac": "NP_571685", "gene_names_uniprotkb": "adarb1a; adar2; adarb1; red1", "gene_names_refseq": "adar2; adarb1a; adarb1; red1", "protein_names_uniprotkb": "3.5.4.4; Double-stranded RNA-specific editase 1a", "protein_names_refseq": "adenosine deaminase, RNA-specific, B1; double-stranded RNA-specific editase 1a; double-stranded RNA-specific editase", "tax_id": 7955, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:58134); (R-DRE-75102); (R-DRE-77042)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11116087;12459255;24818983;26469318;26637167;27189481;28252024;36127363", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF403112.1, GFIL01000534.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 12459255 ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Dec 1, 2007 this sequence version replaced NP_571685.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Adar2 Edits the Q/R site of AMPA receptor Subunit gria2alpha transcript to ensure normal development of nervous system and cranial neural crest cells Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IF19;A5WUX1", "ec_number_list": "3.5.4.4", "go_molecular_function": "GO:0003723 RNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0007399 nervous system development;GO:0014032 neural crest cell development;GO:0016553 base conversion or substitution editing;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M1P669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P6A3-1", "uniprot_id": "A0A8M1P6A3_DANRE", "mass": 30898.0, "length": 267, "protein_name": "Alkaline ceramidase", "gene_name": "acer3", "organism": "Zebrafish", "refseq_name": "alkaline ceramidase 3", "refseq_ac": "NP_001280621", "gene_names_uniprotkb": "acer3; si:ch211-30e10.5", "gene_names_refseq": "acer3; si:ch211-30e10.5", "protein_names_uniprotkb": "Alkaline ceramidase; 3.5.1.-", "protein_names_refseq": "alkaline ceramidase 3", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); leukodystrophy (Disease Ontology:DOID:10579); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "26469318;28956531", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588724.960549.1, SRR32588733.143120.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476733 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jun 25, 2025 this sequence version replaced NP_001280621.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.-;3.5.1.23", "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046512 sphingosine biosynthetic process;GO:0006672 ceramide metabolic process;GO:0071602 phytosphingosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1P6A3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P6B6-1", "uniprot_id": "A0A8M1P6B6_DANRE", "mass": 114763.0, "length": 999, "protein_name": "E3 ubiquitin-protein ligase Topors", "gene_name": "toporsa", "organism": "Zebrafish", "refseq_name": "topoisomerase I binding, arginine/serine-rich a", "refseq_ac": "NP_001292484", "gene_names_uniprotkb": "toporsa; si:ch211-145b13.4; topors; wu:fc21e07", "gene_names_refseq": "si:ch211-145b13.4; toporsa; topors; wu:fc21e07", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Topors; 2.3.2.27; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; Tumor suppressor p53-binding protein 3", "protein_names_refseq": "topoisomerase I binding, arginine/serine-rich a", "tax_id": 7955, "disease": "retinitis pigmentosa 31 (Disease Ontology:DOID:0110391)", "pathway": " (dre:324197)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21159800;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.582848.1, SRR32588734.1084555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH593328.1 and JBMGRA010000001.1. On Mar 18, 2015 this sequence version replaced XP_687895.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7EXN7;E7F1A2;F6N9Q9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0010842 retina layer formation;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1P6B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P6Z4-1", "uniprot_id": "A0A8M1P6Z4_DANRE", "mass": 89430.0, "length": 813, "protein_name": "E3 ubiquitin-protein ligase TRIM71", "gene_name": "trim71", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase TRIM71", "refseq_ac": "NP_001288260", "gene_names_uniprotkb": "trim71; cb205; fb93a12; lin41; sb:cb205; wu:fb93a12", "gene_names_refseq": "cb205; fb93a12; lin41; sb:cb205; trim71; wu:fb93a12", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM71; 2.3.2.27; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM71; RING-type E3 ubiquitin transferase TRIM71; lin-41 homolog; protein lin-41 homolog; tripartite motif-containing 71; tripartite motif-containing protein 71", "tax_id": 7955, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dre:561754)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10882102;11081512;17890240;19420057;21789205;24516585;26469318;27189481;38036331", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01009343.1, SRR26395012.1157426.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Aug 5, 2014 this sequence version replaced XP_690252.5., [RefSeq]; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development., [UniProtKB, UniProtKB]; Repression of human TRIM71 and the zebrafish lin-41 ortholog was abolished when predicted let-7 target sites were mutated. Regulation of TRIM71 expression by let-7 seems to have been evolutionarily conserved., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0035198 miRNA binding", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0007399 nervous system development;GO:0017148 negative regulation of translation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1P6Z4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P706-1", "uniprot_id": "A0A8M1P706_DANRE", "mass": 49082.0, "length": 433, "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "ptpn1", "organism": "Zebrafish", "refseq_name": "tyrosine-protein phosphatase non-receptor type 1", "refseq_ac": "NP_001300614", "gene_names_uniprotkb": "ptpn1; ptp1b; wu:fk54h03", "gene_names_refseq": "ptp1b; ptpn1; wu:fk54h03", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type; 3.1.3.48", "protein_names_refseq": "protein tyrosine phosphatase 1b; tyrosine-protein phosphatase non-receptor type 1", "tax_id": 7955, "disease": "intestinal cancer (Disease Ontology:DOID:10155); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:30081)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10707902;18955058;20434959;20838449;23399444;23974070;26469318;27210033;28814789;33456749;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049294.1, SRR26395014.1063379.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:1903898 negative regulation of PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1P706-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P7C1-1", "uniprot_id": "A0A8M1P7C1_DANRE", "mass": 183178.0, "length": 1643, "protein_name": "3.4.21.43; Complement C3a.1 precursor", "gene_name": "c3a.1", "organism": "Zebrafish", "refseq_name": "complement C3a.1 precursor", "refseq_ac": "NP_571317", "gene_names_uniprotkb": "c3a.1; C3-1; C3; c3a; cb26; sb:cb26; si:dkey-76b14.4; wu:fi34b03; wu:fj86e11", "gene_names_refseq": "C3-1; C3; c3a.1; c3a; cb26; sb:cb26; si:dkey-76b14.4; wu:fi34b03; wu:fj86e11", "protein_names_uniprotkb": "3.4.21.43; Complement C3a.1 precursor", "protein_names_refseq": "c3.1; complement C3a.1 precursor; complement component 3; complement component c3a, duplicate 1", "tax_id": 7955, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); age related macular degeneration 7 (Disease Ontology:DOID:0110019); age related macular degeneration 9 (Disease Ontology:DOID:0110021); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); dry eye syndrome (Disease Ontology:DOID:10140); silicosis (Disease Ontology:DOID:10325); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); lepromatous leprosy (Disease Ontology:DOID:10887); sickle cell anemia (Disease Ontology:DOID:10923); membranous glomerulonephritis (Disease Ontology:DOID:10976); pneumocystosis (Disease Ontology:DOID:11339); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); factor VIII deficiency (Disease Ontology:DOID:12134); neurodegenerative disease (Disease Ontology:DOID:1289); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); boutonneuse fever (Disease Ontology:DOID:14095); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); mood disorder (Disease Ontology:DOID:3324); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); arteriolosclerosis (Disease Ontology:DOID:5162); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); conjunctivitis (Disease Ontology:DOID:6195); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); complement component 3 deficiency (Disease Ontology:DOID:8354); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:321046)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12234255;15070763;17823451;18248169;36310614;36713462;36736605;37489330;38927252;40044042;9874500", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF595146.1, EE304206.1, DT075162.1, AW170905.1, BU709691.1, EB927372.1, EE312111.1, EE711390.1, CK868177.1, BQ074354.1, CN329603.1 and BQ074523.1. On Dec 18, 2011 this sequence version replaced XP_002660621.2. Sequence Note: This RefSeq record was created from transcripts of different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mediator of local inflammatory process released following cleavage by C3 convertase. Acts by binding to its receptor, C3AR1, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C3AR1. C3a anaphylatoxin stimulates the activation of immune cells such as mast cells and basophilic leukocytes to release inflammation agents, such as cytokines, chemokines and histamine, which promote inflammation development. Also acts as potent chemoattractant for the migration of macrophages and neutrophils to the inflamed tissues, resulting in neutralization of the inflammatory triggers by multiple ways, such as phagocytosis and generation of reactive oxidants., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043009 chordate embryonic development;GO:1902624 positive regulation of neutrophil migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M1P7C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P7E6-1", "uniprot_id": "A0A8M1P7E6_DANRE", "mass": 62610.0, "length": 546, "protein_name": "Tryptophan 5-hydroxylase 2", "gene_name": "tph2", "organism": "Zebrafish", "refseq_name": "tryptophan 5-hydroxylase 2 isoform 1", "refseq_ac": "NP_001296997", "gene_names_uniprotkb": "tph2; tphR; wu:fq15a04", "gene_names_refseq": "tph2; tphR; wu:fq15a04", "protein_names_uniprotkb": "Tryptophan 5-hydroxylase 2; 1.14.16.4; Tryptophan 5-monooxygenase 2", "protein_names_refseq": "tph2a; tryptophan 5-hydroxylase 2 isoform 1; tryptophan hydroxylase R", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); sleep apnea (Disease Ontology:DOID:0050847); autism spectrum disorder (Disease Ontology:DOID:0060041); traumatic brain injury (Disease Ontology:DOID:0081292); hypertension (Disease Ontology:DOID:10763); autistic disorder (Disease Ontology:DOID:12849); premature ejaculation (Disease Ontology:DOID:13709); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); melancholic depression (Disease Ontology:DOID:1595); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); psychotic disorder (Disease Ontology:DOID:2468); bipolar disorder (Disease Ontology:DOID:3312); panic disorder (Disease Ontology:DOID:594); acute stress disorder (Disease Ontology:DOID:6088); premenstrual tension (Disease Ontology:DOID:727); subacute delirium (Disease Ontology:DOID:8645); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:407712)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15281067;15652156;15677724;16498236;17304529;37529101;38416162;38626530;38977301;39084264", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY616134.1, BC162621.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1 and EB870154.1. On Jun 25, 2015 this sequence version replaced XP_005159132.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; TphR is expressed in serotonergic raphe neurons, similar to tph genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.16.4", "go_molecular_function": "GO:0004510 tryptophan 5-monooxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0043005 neuron projection", "go_biological_process": "GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0042427 serotonin biosynthetic process;GO:0009072 aromatic amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P7E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P7L2-1", "uniprot_id": "A0A8M1P7L2_DANRE", "mass": 147173.0, "length": 1358, "protein_name": "OTU domain-containing protein 4", "gene_name": "otud4", "organism": "Zebrafish", "refseq_name": "OTU domain-containing protein 4 isoform 3", "refseq_ac": "NP_001299588", "gene_names_uniprotkb": "otud4; wu:fd14a11; wu:fe11h08; zgc:165536", "gene_names_refseq": "otud4; wu:fd14a11; wu:fe11h08; zgc:165536", "protein_names_uniprotkb": "OTU domain-containing protein 4; 3.4.19.12", "protein_names_refseq": "OTU domain containing 4 protein; OTU domain-containing protein 4 isoform 3; parp11", "tax_id": 7955, "disease": "", "pathway": " (dre:327127)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20040115;23656588;23665588;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.3033938.1, SRR32588724.577844.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jun 7, 2025 this sequence version replaced NP_001299588.3., [RefSeq]; Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions., [UniProtKB, UniProtKB]; Interruption of Bmp4 signaling by double knockdown of usp15 and otud4 reduced the ventralized effects in tsc22d3-overexpressing embryos, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0070536 protein K63-linked deubiquitination;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M1P7L2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P8P4-1", "uniprot_id": "A0A8M1P8P4_DANRE", "mass": 54878.0, "length": 492, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr151", "organism": "Zebrafish", "refseq_name": "Pim proto-oncogene, serine/threonine kinase, related 151", "refseq_ac": "NP_001314958", "gene_names_uniprotkb": "pimr151; si:dkey-112g5.5", "gene_names_refseq": "pimr151; si:dkey-112g5.5", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "Pim proto-oncogene, serine/threonine kinase, related 151", "tax_id": 7955, "disease": "", "pathway": " (dre:796511)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21873635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.9945179.1 [ECO:0000332] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JBMGRA010000013.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M1P8P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P8P5-1", "uniprot_id": "A0A8M1P8P5_DANRE", "mass": 77117.0, "length": 709, "protein_name": "3.4.21.-; Proprotein convertase subtilisin/kexin type 7 precursor", "gene_name": "pcsk7", "organism": "Zebrafish", "refseq_name": "proprotein convertase subtilisin/kexin type 7 precursor", "refseq_ac": "NP_001307357", "gene_names_uniprotkb": "pcsk7; fj05c03; wu:fj05c03; zgc:158336", "gene_names_refseq": "fj05c03; pcsk7; wu:fj05c03; zgc:158336", "protein_names_uniprotkb": "3.4.21.-; Proprotein convertase subtilisin/kexin type 7 precursor", "protein_names_refseq": "proprotein convertase subtilisin/kexin type 7 precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:100009656); (R-DRE-9768727)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22045484;24178295;25624351;26469318;27189481;28624236", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC133084.1, SRR32588720.1428629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Jul 24, 2025 this sequence version replaced NP_001307357.1. Sequence Note:., [RefSeq]; PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R440", "ec_number_list": "3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016485 protein processing;GO:0007420 brain development;GO:0048840 otolith development;GO:0001654 eye development;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M1P8P5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P933-1", "uniprot_id": "A0A8M1P933_DANRE", "mass": 67570.0, "length": 591, "protein_name": "Sphingomyelin phosphodiesterase", "gene_name": "smpd1", "organism": "Zebrafish", "refseq_name": "sphingomyelin phosphodiesterase precursor", "refseq_ac": "NP_001313465", "gene_names_uniprotkb": "smpd1; si:ch211-287a12.10", "gene_names_refseq": "si:ch211-287a12.10; smpd1", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase; 3.1.4.12", "protein_names_refseq": "sphingomyelin phosphodiesterase 1, acid lysosomal; sphingomyelin phosphodiesterase precursor", "tax_id": 7955, "disease": "Niemann-Pick disease type A (Disease Ontology:DOID:0070111); Niemann-Pick disease type B (Disease Ontology:DOID:0070112); Niemann-Pick disease (Disease Ontology:DOID:14504); Wilson disease (Disease Ontology:DOID:893)", "pathway": " (dre:556700)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "26469318;26992035;27189481;30718751;30765415;33164759;36835354;36951087;37183607", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01039052.1, BC154648.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jun 25, 2025 this sequence version replaced NP_001313465.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form., [UniProtKB, UniProtKB]; In the lysosomes, converts sphingomyelin to ceramide. Plays an important role in the export of cholesterol from the intraendolysosomal membranes. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Modulates stress-induced apoptosis through the production of ceramide., [UniProtKB, UniProtKB]; This form is generated following cleavage by CASP7 in the extracellular milieu in response to bacterial infection. It shows increased ability to convert sphingomyelin to ceramide and promotes plasma membrane repair. Plasma membrane repair by ceramide counteracts the action of gasdermin-D (GSDMD) perforin (PRF1) pores that are formed in response to bacterial infection., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.12", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061750 acid sphingomyelin phosphodiesterase activity;GO:0034480 phosphatidylcholine phospholipase C activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0006685 sphingomyelin catabolic process;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1P933-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P943-1", "uniprot_id": "A0A8M1P943_DANRE", "mass": 74603.0, "length": 659, "protein_name": "Cryptochrome circadian regulator 3a isoform 2; Cryptochrome circadian regulator 3a isoform X1", "gene_name": "cry3a", "organism": "Zebrafish", "refseq_name": "cryptochrome circadian regulator 3a isoform 2", "refseq_ac": "NP_571866", "gene_names_uniprotkb": "cry3a; cry1ba; cry2a; zgc:110521", "gene_names_refseq": "cry1ba; cry2a; cry3a; zgc:110521", "protein_names_uniprotkb": "Cryptochrome circadian regulator 3a isoform 2; Cryptochrome circadian regulator 3a isoform X1", "protein_names_refseq": "cryptochrome 2a; cryptochrome circadian clock 1ba; cryptochrome circadian regulator 1ba; cryptochrome circadian regulator 3a isoform 2", "tax_id": 7955, "disease": "delayed sleep phase syndrome (Disease Ontology:DOID:0111141)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "10971654;12001265;12111534;16176122;20830285;33847185;34334501;34925060;35672786;37075492", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.16187392.1, SRR32588714.16744054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH447304.1 and JBMGRA010000008.1. On Sep 5, 2015 this sequence version replaced NP_571866.1. Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is longer than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S7X5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0071949 FAD binding;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0009266 response to temperature stimulus;GO:0032922 circadian regulation of gene expression;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P9G4-1", "uniprot_id": "A0A8M1P9G4_DANRE", "mass": 84503.0, "length": 797, "protein_name": "Disabled homolog 2 isoform X1; Disabled homolog 2 isoform a", "gene_name": "dab2", "organism": "Zebrafish", "refseq_name": "disabled homolog 2 isoform a", "refseq_ac": "NP_001314800", "gene_names_uniprotkb": "dab2; sb:cb778; zgc:77136", "gene_names_refseq": "dab2; sb:cb778; zgc:77136", "protein_names_uniprotkb": "Disabled homolog 2 isoform X1; Disabled homolog 2 isoform a", "protein_names_refseq": "Dab, mitogen-responsive phosphoprotein, homolog 2; disabled homolog 2 isoform a; disabled homolog 2", "tax_id": 7955, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:404040); (R-DRE-196025); (R-DRE-8856825)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15520368;16638803;16999953;17722983;18032732;38605226;39101673;39178846;39365738;39537736", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395013.488870.1, SRR26395017.1108934.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On May 27, 2016 this sequence version replaced XP_005171877.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JI86;B8A566", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0001525 angiogenesis;GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1P9G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1P9J6-1", "uniprot_id": "A0A8M1P9J6_DANRE", "mass": 125894.0, "length": 1135, "protein_name": "DNA helicase MCM9", "gene_name": "mcm9", "organism": "Zebrafish", "refseq_name": "DNA helicase MCM9", "refseq_ac": "NP_001333089", "gene_names_uniprotkb": "mcm9; mcmdc1; si:ch211-112m17.2", "gene_names_refseq": "mcm9; mcmdc1; si:ch211-112m17.2", "protein_names_uniprotkb": "DNA helicase MCM9; 5.6.2.4; DNA 3'-5' helicase MCM9; Minichromosome maintenance 9", "protein_names_refseq": "DNA 3'-5' helicase MCM9; DNA helicase MCM9; minichromosome maintenance complex component 9; minichromosome maintenance deficient domain containing 1; novel mcm domain containing protein", "tax_id": 7955, "disease": "ovarian dysgenesis 4 (Disease Ontology:DOID:0080496); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:555610)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01026097.1, SRR32588718.11822456.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898400, SAMEA898401 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Sep 28, 2016 this sequence version replaced XP_683173.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I324;K3W4K9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0097362 MCM8-MCM9 complex", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1P9J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PAE4-1", "uniprot_id": "A0A8M1PAE4_DANRE", "mass": 14480.0, "length": 127, "protein_name": "Selenoprotein H", "gene_name": "selenoh", "organism": "Zebrafish", "refseq_name": "selenoprotein H", "refseq_ac": "NP_835234", "gene_names_uniprotkb": "selenoh; cb697; selh; seph; wu:fa11g07; wu:fb23d03", "gene_names_refseq": "cb697; selenoh; selh; seph; wu:fa11g07; wu:fb23d03", "protein_names_uniprotkb": "Selenoprotein H", "protein_names_refseq": "etID39515.8; selenoprotein H", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)", "pathway": " (dre:347743)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12775843;12915322;15256591;22479358;25064324;27588899;30837464;32296464;38042913", "class_list": "", "function": "##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EH510258.1 and CT670471.2. On Mar 1, 2008 this sequence version replaced NP_835234.1. This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase; and in mammals, it has been shown to protect neurons against UVB-induced damage, promote mitochondrial biogenesis, and suppress cellular senescence. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017]., [RefSeq]; May be involved in a redox-related process., [UniProtKB, UniProtKB]; Transcriptome analysis revealed that SepH deficiency induces an inflammatory response and activates the p53 pathway. Consequently, loss of seph renders larvae susceptible to oxidative stress and DNA damage. Finally, we demonstrate that seph interacts with p53 deficiency in adulthood to accelerate gastrointestinal tumor development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001889 liver development;GO:0031016 pancreas development;GO:0045454 cell redox homeostasis;GO:0048565 digestive tract development;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M1PAE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PAJ9-1", "uniprot_id": "A0A8M1PAJ9_DANRE", "mass": 22123.0, "length": 191, "protein_name": "Glutathione peroxidase", "gene_name": "gpx2", "organism": "Zebrafish", "refseq_name": "glutathione peroxidase 2", "refseq_ac": "NP_001316688", "gene_names_uniprotkb": "gpx2; si:ch73-199k24.2", "gene_names_refseq": "gpx2; si:ch73-199k24.2", "protein_names_uniprotkb": "Glutathione peroxidase", "protein_names_refseq": "glutathione peroxidase 2 (gastrointestinal); glutathione peroxidase 2", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199); ulcerative colitis (Disease Ontology:DOID:8577); alcoholic gastritis (Disease Ontology:DOID:8680); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:100334384)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "22479358;24683187;26469318;26494580;32987694;34111665;36598134;37031846", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.142404.1, SRR26395012.1228475.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JBMGRA010000017.1. On Jul 27, 2016 this sequence version replaced XP_009291566.2. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.99.3;2.5.1.18;1.11.1.9", "go_molecular_function": "GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M1PAJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PCD1-1", "uniprot_id": "A0A8M1PCD1_DANRE", "mass": 66118.0, "length": 602, "protein_name": "thioredoxin-disulfide reductase (NADPH)", "gene_name": "txnrd3", "organism": "Zebrafish", "refseq_name": "thioredoxin reductase 3", "refseq_ac": "NP_898895", "gene_names_uniprotkb": "txnrd3; TrxR1; TrxR2; cb682; cb683; fb83a08; txnrd1; wu:fb83a08", "gene_names_refseq": "TrxR1; TrxR2; cb682; cb683; fb83a08; txnrd1; txnrd3; wu:fb83a08", "protein_names_uniprotkb": "thioredoxin-disulfide reductase (NADPH); 1.8.1.9", "protein_names_refseq": "thioredoxin reductase 3", "tax_id": 7955, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)", "pathway": " (dre:352924)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11259642;12915322;20659579;22479358;23737534;34537895;35210313;35469838;38042913;38509740", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01001378.1, BC054599.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EB861362.1, BC054599.1 and JBMGRA010000006.1. On May 23, 2007 this sequence version replaced NP_898895.1. The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a TrxR isozyme similar to the third mammalian TrxR, which contains an additional N-terminal glutaredoxin (Grx) domain. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Feb 2018]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1PCD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PE71-1", "uniprot_id": "A0A8M1PE71_DANRE", "mass": 110320.0, "length": 963, "protein_name": "Aminopeptidase", "gene_name": "erap1b", "organism": "Zebrafish", "refseq_name": "endoplasmic reticulum aminopeptidase 1b precursor", "refseq_ac": "NP_956500", "gene_names_uniprotkb": "erap1b; ARTS-1; zgc:56194", "gene_names_refseq": "ARTS-1; erap1b; zgc:56194", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "endoplasmic reticulum aminopeptidase 1b precursor; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator", "tax_id": 7955, "disease": "severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893)", "pathway": " (dre:393175)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;26469318;28252024;40044042", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On or before Jan 21, 2011 this sequence version replaced XP_002662043.1, NP_956500.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0008237 metallopeptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M1PE71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PFK7-1", "uniprot_id": "A0A8M1PFK7_DANRE", "mass": 85969.0, "length": 761, "protein_name": "Anaphase-promoting complex subunit 5", "gene_name": "anapc5", "organism": "Zebrafish", "refseq_name": "anaphase-promoting complex subunit 5", "refseq_ac": "NP_955916", "gene_names_uniprotkb": "anapc5; wu:fb75a09; zgc:55800", "gene_names_refseq": "anapc5; wu:fb75a09; zgc:55800", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 5; Cyclosome subunit 5", "protein_names_refseq": "anaphase-promoting complex subunit 5", "tax_id": 7955, "disease": "", "pathway": " (dre:322854)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27189481;28631837", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045458.1, GDQH01026037.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1 and EH552132.1. On Jun 12, 2015 this sequence version replaced NP_955916.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005819 spindle;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1PFK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PGD6-1", "uniprot_id": "A0A8M1PGD6_DANRE", "mass": 37311.0, "length": 322, "protein_name": "m7GpppX diphosphatase", "gene_name": "dcps", "organism": "Zebrafish", "refseq_name": "m7GpppX diphosphatase", "refseq_ac": "NP_991151", "gene_names_uniprotkb": "dcps; wu:fa04d04; zgc:109723", "gene_names_refseq": "dcps; wu:fa04d04; zgc:109723", "protein_names_uniprotkb": "m7GpppX diphosphatase; 3.6.1.59", "protein_names_refseq": "histidine triad protein member 5; m7GpppX diphosphatase; mRNA decapping enzyme", "tax_id": 7955, "disease": "", "pathway": " (dre:402850); (R-DRE-429958)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF510720.1, BC164351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH547457.1 and JBMGRA010000010.1. On Feb 19, 2016 this sequence version replaced NP_991151.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R776", "ec_number_list": "3.6.1.59", "go_molecular_function": "GO:0000340 RNA 7-methylguanosine cap binding;GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M1PGD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PRV5-1", "uniprot_id": "A0A8M1PRV5_DANRE", "mass": 49868.0, "length": 445, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr142", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-1-like", "refseq_ac": "XP_001333298", "gene_names_uniprotkb": "pimr142", "gene_names_refseq": "pimr142", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:795594)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_001333298.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PRV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PT03-1", "uniprot_id": "A0A8M1PT03_DANRE", "mass": 33448.0, "length": 291, "protein_name": "Syntaxin-1A", "gene_name": "stx1a", "organism": "Zebrafish", "refseq_name": "syntaxin-1A", "refseq_ac": "XP_001345316", "gene_names_uniprotkb": "stx1a", "gene_names_refseq": "stx1a", "protein_names_uniprotkb": "Syntaxin-1A", "protein_names_refseq": "syntaxin-1A", "tax_id": 7955, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); disease of mental health (Disease Ontology:DOID:150); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:100006625)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_001345316.2. COMPLETENESS: full length., [RefSeq]; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0006906 vesicle fusion;GO:0048278 vesicle docking;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PT03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PUX9-1", "uniprot_id": "A0A8M1PUX9_DANRE", "mass": 59905.0, "length": 532, "protein_name": "Occludin", "gene_name": "si:ch73-61d6.3", "organism": "Zebrafish", "refseq_name": "occludin", "refseq_ac": "XP_001341204", "gene_names_uniprotkb": "si:ch73-61d6.3", "gene_names_refseq": "si:ch73-61d6.3", "protein_names_uniprotkb": "Occludin", "protein_names_refseq": "occludin", "tax_id": 7955, "disease": "", "pathway": " (dre:100001136)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001341204.2. COMPLETENESS: full length., [RefSeq]; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0070830 bicellular tight junction assembly;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0042795 snRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PUX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PZ01-1", "uniprot_id": "A0A8M1PZ01_DANRE", "mass": 48711.0, "length": 419, "protein_name": "Guanine nucleotide-binding protein G(s) subunit alpha", "gene_name": "gnas", "organism": "Zebrafish", "refseq_name": "GNAS complex locus isoform 2", "refseq_ac": "NP_001429019", "gene_names_uniprotkb": "gnas", "gene_names_refseq": "gnas", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(s) subunit alpha; Adenylate cyclase-stimulating G alpha protein", "protein_names_refseq": "GNAS complex locus isoform 2; Galpha s", "tax_id": 7955, "disease": "pseudohypoparathyroidism type 1C (Disease Ontology:DOID:0051013); pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222); polycystic kidney disease (Disease Ontology:DOID:0080322); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); ACTH-independent macronodular adrenal hyperplasia 1 (Disease Ontology:DOID:0111623); pituitary adenoma 3 (Disease Ontology:DOID:0112010); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pancreatic cancer (Disease Ontology:DOID:1793); McCune Albright syndrome (Disease Ontology:DOID:1858); pseudopseudohypoparathyroidism (Disease Ontology:DOID:4183); pseudohypoparathyroidism (Disease Ontology:DOID:4184); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:557353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.3298771.1, SRR32588735.3251491.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jul 24, 2025 this sequence version replaced XP_001335732.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0006638 neutral lipid metabolic process;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007606 sensory perception of chemical stimulus;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PZ01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PZ39-1", "uniprot_id": "A0A8M1PZ39_DANRE", "mass": 26224.0, "length": 227, "protein_name": "EPH-related receptor tyrosine kinase ligand 7", "gene_name": "efna5a", "organism": "Zebrafish", "refseq_name": "ephrin-A5b isoform X1", "refseq_ac": "XP_001337388", "gene_names_uniprotkb": "efna5a", "gene_names_refseq": "efna5a", "protein_names_uniprotkb": "EPH-related receptor tyrosine kinase ligand 7", "protein_names_refseq": "ephrin-A5b isoform X1", "tax_id": 7955, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (dre:64256)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001337388.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway;GO:0022407 regulation of cell-cell adhesion;GO:0007411 axon guidance;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PZ39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1PZF1-1", "uniprot_id": "A0A8M1PZF1_DANRE", "mass": 23884.0, "length": 210, "protein_name": "Sclerostin", "gene_name": "sost", "organism": "Zebrafish", "refseq_name": "sclerostin", "refseq_ac": "XP_001340683", "gene_names_uniprotkb": "sost", "gene_names_refseq": "sost", "protein_names_uniprotkb": "Sclerostin", "protein_names_refseq": "sclerostin", "tax_id": 7955, "disease": "sclerosteosis (Disease Ontology:DOID:0060251); sclerosteosis 1 (Disease Ontology:DOID:0060756); SOST-related sclerosing bone dysplasia (Disease Ontology:DOID:0080036); autosomal dominant craniodiaphyseal dysplasia (Disease Ontology:DOID:0080807)", "pathway": " (dre:100000500)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_001340683.1. COMPLETENESS: full length., [RefSeq]; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1PZF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1Q1F6-1", "uniprot_id": "A0A8M1Q1F6_DANRE", "mass": 46180.0, "length": 409, "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "nceh1b.2", "organism": "Zebrafish", "refseq_name": "neutral cholesterol ester hydrolase 1", "refseq_ac": "XP_073796962", "gene_names_uniprotkb": "nceh1b.2", "gene_names_refseq": "nceh1b.2", "protein_names_uniprotkb": "Neutral cholesterol ester hydrolase 1; 3.1.1.71; Acetylalkylglycerol acetylhydrolase; Arylacetamide deacetylase-like 1", "protein_names_refseq": "neutral cholesterol ester hydrolase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:797436)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IRV8", "ec_number_list": "3.1.1.-;3.1.1.71;3.1.1.23;3.1.1.79", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0017171 serine hydrolase activity;GO:0047378 acetylalkylglycerol acetylhydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1Q1F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1Q2B6-1", "uniprot_id": "A0A8M1Q2B6_DANRE", "mass": 52653.0, "length": 461, "protein_name": "Collagenase 3", "gene_name": "mmp13b", "organism": "Zebrafish", "refseq_name": "collagenase 3", "refseq_ac": "XP_001345507", "gene_names_uniprotkb": "mmp13b", "gene_names_refseq": "mmp13b", "protein_names_uniprotkb": "Collagenase 3; Matrix metalloproteinase-13", "protein_names_refseq": "collagenase 3", "tax_id": 7955, "disease": "spondyloepimetaphyseal dysplasia, Missouri type (Disease Ontology:DOID:0080030); meningococcal meningitis (Disease Ontology:DOID:0080176); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); vulva cancer (Disease Ontology:DOID:1245); anodontia (Disease Ontology:DOID:13714); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (dre:100006896)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HDE7", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1Q2B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1Q6V5-1", "uniprot_id": "A0A8M1Q6V5_DANRE", "mass": 111458.0, "length": 1004, "protein_name": "Alanine--tRNA ligase", "gene_name": "LOC100536819; aars2", "organism": "Zebrafish", "refseq_name": "alanine--tRNA ligase, mitochondrial isoform X1", "refseq_ac": "XP_001332388", "gene_names_uniprotkb": "LOC100536819; aars2; AARS", "gene_names_refseq": "aars2", "protein_names_uniprotkb": "Alanine--tRNA ligase; 6.1.1.7", "protein_names_refseq": "alanine--tRNA ligase, mitochondrial isoform X1", "tax_id": 7955, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); progressive leukoencephalopathy with ovarian failure (Disease Ontology:DOID:0070396); combined oxidative phosphorylation deficiency 8 (Disease Ontology:DOID:0111479); dermatomyositis (Disease Ontology:DOID:10223); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (dre:100536819); (dre:792787)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001332388.4. COMPLETENESS: full length., [RefSeq]; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.7;2.4.1.-", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004813 alanine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0000139 Golgi membrane", "go_biological_process": "GO:0070143 mitochondrial alanyl-tRNA aminoacylation;GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1Q6V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1Q7Z4-1", "uniprot_id": "A0A8M1Q7Z4_DANRE", "mass": 114546.0, "length": 994, "protein_name": "Aminopeptidase", "gene_name": "trhde.1", "organism": "Zebrafish", "refseq_name": "thyrotropin-releasing hormone-degrading ectoenzyme isoform X1", "refseq_ac": "XP_001345457", "gene_names_uniprotkb": "trhde.1", "gene_names_refseq": "trhde.1", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "thyrotropin-releasing hormone-degrading ectoenzyme isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100006808)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_001345457.2. COMPLETENESS: full length., [RefSeq]; Specific inactivation of TRH after its release., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016920 pyroglutamyl-peptidase activity;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1Q7Z4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QHZ3-1", "uniprot_id": "A0A8M1QHZ3_DANRE", "mass": 50993.0, "length": 465, "protein_name": "Glutamate receptor", "gene_name": "grik6", "organism": "Zebrafish", "refseq_name": "probable glutamate receptor", "refseq_ac": "XP_021335521", "gene_names_uniprotkb": "grik6", "gene_names_refseq": "grik6", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "probable glutamate receptor", "tax_id": 7955, "disease": "", "pathway": " (dre:100151589)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F5R2", "ec_number_list": "", "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QHZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QKP5-1", "uniprot_id": "A0A8M1QKP5_DANRE", "mass": 103320.0, "length": 918, "protein_name": "Lysosomal alpha-glucosidase", "gene_name": "gaa", "organism": "Zebrafish", "refseq_name": "lysosomal alpha-glucosidase isoform X1", "refseq_ac": "XP_001921957", "gene_names_uniprotkb": "gaa", "gene_names_refseq": "gaa", "protein_names_uniprotkb": "Lysosomal alpha-glucosidase; Acid maltase", "protein_names_refseq": "lysosomal alpha-glucosidase isoform X1", "tax_id": 7955, "disease": "glycogen storage disease II (Disease Ontology:DOID:2752)", "pathway": " (dre:100002366)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001921957.1. COMPLETENESS: full length., [RefSeq]; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0030246 carbohydrate binding;GO:0090599 alpha-glucosidase activity", "go_cellular_component": "GO:0045202 synapse;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0007040 lysosome organization;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QKP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QQZ0-1", "uniprot_id": "A0A8M1QQZ0_DANRE", "mass": 78290.0, "length": 695, "protein_name": "Protein kinase C", "gene_name": "prkcg", "organism": "Zebrafish", "refseq_name": "protein kinase C alpha type isoform X1", "refseq_ac": "XP_001921715", "gene_names_uniprotkb": "prkcg", "gene_names_refseq": "prkcg", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "protein kinase C alpha type isoform X1", "tax_id": 7955, "disease": "spinocerebellar ataxia 14 (Disease Ontology:DOID:0050964); alcohol use disorder (Disease Ontology:DOID:1574); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dre:100003514)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0001881 receptor recycling;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QQZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RDA3-1", "uniprot_id": "A0A8M1RDA3_DANRE", "mass": 78436.0, "length": 731, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "dtx4b", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase DTX4", "refseq_ac": "XP_002660570", "gene_names_uniprotkb": "dtx4b", "gene_names_refseq": "dtx4b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase DTX4", "tax_id": 7955, "disease": "", "pathway": " (dre:100037355)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RDA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RFS1-1", "uniprot_id": "A0A8M1RFS1_DANRE", "mass": 19435.0, "length": 170, "protein_name": "Cyclin-dependent kinase inhibitor 1 isoform X1", "gene_name": "cdkn1a", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase inhibitor 1 isoform X1", "refseq_ac": "XP_003200962", "gene_names_uniprotkb": "cdkn1a; cip1; p21; si:ch1073-48m5.2; waf1", "gene_names_refseq": "cdkn1a; cip1; p21; si:ch1073-48m5.2; waf1", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor 1 isoform X1", "protein_names_refseq": "cyclin-dependent kinase inhibitor 1 isoform X1", "tax_id": 7955, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); prostate cancer (Disease Ontology:DOID:10283); primary open angle glaucoma (Disease Ontology:DOID:1070); renal hypertension (Disease Ontology:DOID:1073); cholesteatoma of middle ear (Disease Ontology:DOID:10964); lipoid nephrosis (Disease Ontology:DOID:10966); sarcoidosis (Disease Ontology:DOID:11335); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); primary biliary cholangitis (Disease Ontology:DOID:12236); acoustic neuroma (Disease Ontology:DOID:12689); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); papilloma (Disease Ontology:DOID:2615); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); high grade glioma (Disease Ontology:DOID:3070); serous cystadenocarcinoma (Disease Ontology:DOID:3114); inverted papilloma (Disease Ontology:DOID:3179); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); pancreatic carcinoma (Disease Ontology:DOID:4905); stomach carcinoma (Disease Ontology:DOID:5517); sebaceous gland neoplasm (Disease Ontology:DOID:5759); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); maxillary sinus squamous cell carcinoma (Disease Ontology:DOID:7910); retinal degeneration (Disease Ontology:DOID:8466); ulcerative colitis (Disease Ontology:DOID:8577); psoriasis (Disease Ontology:DOID:8893); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); liver benign neoplasm (Disease Ontology:DOID:916); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 42, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0035904 aorta development;GO:0035914 skeletal muscle cell differentiation;GO:0010165 response to X-ray;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RFS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RI45-1", "uniprot_id": "A0A8M1RI45_DANRE", "mass": 531870.0, "length": 4667, "protein_name": "Dynein axonemal heavy chain 5", "gene_name": "dnah5l", "organism": "Zebrafish", "refseq_name": "dynein axonemal heavy chain 5", "refseq_ac": "XP_002666734", "gene_names_uniprotkb": "dnah5l", "gene_names_refseq": "dnah5l", "protein_names_uniprotkb": "Dynein axonemal heavy chain 5", "protein_names_refseq": "dynein axonemal heavy chain 5", "tax_id": 7955, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dre:335340)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002666734.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0061371 determination of heart left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RI45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RII2-1", "uniprot_id": "A0A8M1RII2_DANRE", "mass": 30813.0, "length": 271, "protein_name": "Phosphomannomutase", "gene_name": "pmm1", "organism": "Zebrafish", "refseq_name": "phosphomannomutase 1", "refseq_ac": "NP_001429629", "gene_names_uniprotkb": "pmm1", "gene_names_refseq": "pmm1l; pmm1", "protein_names_uniprotkb": "Phosphomannomutase; 5.4.2.8", "protein_names_refseq": "phosphomannomutase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100007686)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395017.932139.1, SRR32588717.9489296.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Aug 21, 2025 this sequence version replaced XP_003198076.5., [RefSeq]; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.4.2.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004615 phosphomannomutase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0006013 mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RII2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RK21-1", "uniprot_id": "A0A8M1RK21_DANRE", "mass": 101557.0, "length": 923, "protein_name": "10-formyltetrahydrofolate dehydrogenase", "gene_name": "aldh1l2", "organism": "Zebrafish", "refseq_name": "mitochondrial 10-formyltetrahydrofolate dehydrogenase", "refseq_ac": "XP_002661418", "gene_names_uniprotkb": "aldh1l2", "gene_names_refseq": "aldh1l2", "protein_names_uniprotkb": "10-formyltetrahydrofolate dehydrogenase; 1.5.1.6", "protein_names_refseq": "mitochondrial 10-formyltetrahydrofolate dehydrogenase", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (dre:100333269)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002661418.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.6", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0016155 formyltetrahydrofolate dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0009258 10-formyltetrahydrofolate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RK21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RL46-1", "uniprot_id": "A0A8M1RL46_DANRE", "mass": 89259.0, "length": 751, "protein_name": "DNA topoisomerase I", "gene_name": "top1b", "organism": "Zebrafish", "refseq_name": "DNA topoisomerase I, mitochondrial", "refseq_ac": "XP_002666448", "gene_names_uniprotkb": "top1b", "gene_names_refseq": "top1b", "protein_names_uniprotkb": "DNA topoisomerase I; 5.6.2.1; DNA topoisomerase 1", "protein_names_refseq": "DNA topoisomerase I, mitochondrial", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:327179)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002666448.2. COMPLETENESS: full length., [RefSeq]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0007059 chromosome segregation;GO:0006260 DNA replication;GO:0048511 rhythmic process;GO:0006265 DNA topological change", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RL46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RLR4-1", "uniprot_id": "A0A8M1RLR4_DANRE", "mass": 86629.0, "length": 754, "protein_name": "Kinesin-like protein", "gene_name": "kif3ca", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF3C", "refseq_ac": "XP_002661420", "gene_names_uniprotkb": "kif3ca", "gene_names_refseq": "kif3ca", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF3C", "tax_id": 7955, "disease": "", "pathway": " (dre:100333558)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_002661420.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0048731 system development;GO:0060271 cilium assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RLR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMQ6-1", "uniprot_id": "A0A8M1RMQ6_DANRE", "mass": 133304.0, "length": 1174, "protein_name": "adenylate cyclase", "gene_name": "adcy6b", "organism": "Zebrafish", "refseq_name": "adenylate cyclase type 6", "refseq_ac": "XP_002666536", "gene_names_uniprotkb": "adcy6b", "gene_names_refseq": "adcy6b", "protein_names_uniprotkb": "adenylate cyclase; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 6", "tax_id": 7955, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (dre:560807)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002666536.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.1;2.7.7.85", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0022011 myelination in peripheral nervous system;GO:2000826 regulation of heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RN23-1", "uniprot_id": "A0A8M1RN23_DANRE", "mass": 188417.0, "length": 1719, "protein_name": "Structure-specific endonuclease subunit SLX4", "gene_name": "slx4", "organism": "Zebrafish", "refseq_name": "structure-specific endonuclease subunit SLX4", "refseq_ac": "XP_003201146", "gene_names_uniprotkb": "slx4", "gene_names_refseq": "slx4", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX4; BTB/POZ domain-containing protein 12", "protein_names_refseq": "structure-specific endonuclease subunit SLX4", "tax_id": 7955, "disease": "Fanconi-like syndrome (Disease Ontology:DOID:0090066); Fanconi anemia complementation group P (Disease Ontology:DOID:0111092)", "pathway": " (dre:100538153)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003201146.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0033557 Slx1-Slx4 complex", "go_biological_process": "GO:0061010 gallbladder development;GO:0061011 hepatic duct development;GO:0000712 resolution of meiotic recombination intermediates;GO:0006281 DNA repair;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RN23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RNL4-1", "uniprot_id": "A0A8M1RNL4_DANRE", "mass": 77356.0, "length": 678, "protein_name": "Serine/threonine-protein kinase PLK", "gene_name": "plk2a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase PLK2 isoform X1", "refseq_ac": "XP_003199325", "gene_names_uniprotkb": "plk2a", "gene_names_refseq": "plk2a", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK; 2.7.11.21; Polo-like kinase", "protein_names_refseq": "serine/threonine-protein kinase PLK2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100148413)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030425 dendrite", "go_biological_process": "GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RNL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RTI1-1", "uniprot_id": "A0A8M1RTI1_DANRE", "mass": 154126.0, "length": 1392, "protein_name": "adenylate cyclase", "gene_name": "adcy9a", "organism": "Zebrafish", "refseq_name": "adenylate cyclase type 9 isoform X1", "refseq_ac": "XP_003201145", "gene_names_uniprotkb": "adcy9a; adcy9", "gene_names_refseq": "adcy9", "protein_names_uniprotkb": "adenylate cyclase; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 9 isoform X1", "tax_id": 7955, "disease": "newborn respiratory distress syndrome (Disease Ontology:DOID:12716); asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (dre:100333702)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003201145.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.1;2.7.7.85", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RTI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1U6-1", "uniprot_id": "A0A8M2B1U6_DANRE", "mass": 69966.0, "length": 643, "protein_name": "Dihydropyrimidinase-related protein 2", "gene_name": "dpysl2b", "organism": "Zebrafish", "refseq_name": "dihydropyrimidinase-related protein 2b isoform X1", "refseq_ac": "XP_073770079", "gene_names_uniprotkb": "dpysl2b; CRMP-2; CRMP2; dpysl2", "gene_names_refseq": "CRMP-2; CRMP2; dpysl2b; dpysl2", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 2", "protein_names_refseq": "dihydropyrimidinase-related protein 2b isoform X1", "tax_id": 7955, "disease": "hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GKC7", "ec_number_list": "", "go_molecular_function": "GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "go_cellular_component": "GO:0005829 cytosol;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007409 axonogenesis;GO:0030900 forebrain development;GO:0031103 axon regeneration;GO:0048935 peripheral nervous system neuron development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B1U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1V7-1", "uniprot_id": "A0A8M2B1V7_DANRE", "mass": 64392.0, "length": 559, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2", "gene_name": "pfkfb2b", "organism": "Zebrafish", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1", "refseq_ac": "XP_005155899", "gene_names_uniprotkb": "pfkfb2b", "gene_names_refseq": "pfkfb2b", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 2.7.1.105; 3.1.3.46; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1V9-1", "uniprot_id": "A0A8M2B1V9_DANRE", "mass": 57897.0, "length": 511, "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "ppp3ccb", "organism": "Zebrafish", "refseq_name": "protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1", "refseq_ac": "XP_005155370", "gene_names_uniprotkb": "ppp3ccb; im:7163784; zgc:158685", "gene_names_refseq": "im:7163784; ppp3ccb; zgc:158685", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase; 3.1.3.16", "protein_names_refseq": "protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:565241)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20652955;24561038;28252024;30694176", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B1V9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1X4-1", "uniprot_id": "A0A8M2B1X4_DANRE", "mass": 84621.0, "length": 772, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "trim3b", "organism": "Zebrafish", "refseq_name": "tripartite motif-containing protein 3b isoform a", "refseq_ac": "NP_001417818", "gene_names_uniprotkb": "trim3b; zgc:153967", "gene_names_refseq": "trim3b; zgc:153967", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "tripartite motif-containing protein 3b isoform a", "tax_id": 7955, "disease": "autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dre:555391)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21789205;22300786;26469318;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01041988.1, SRR32588724.2732325.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On Jun 6, 2024 this sequence version replaced XP_009303590.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A286YB14;A0AC58GK64", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0007399 nervous system development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B1X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1Y0-1", "uniprot_id": "A0A8M2B1Y0_DANRE", "mass": 108720.0, "length": 970, "protein_name": "Metalloendopeptidase", "gene_name": "bmp1b", "organism": "Zebrafish", "refseq_name": "bone morphogenetic protein 1b isoform X1", "refseq_ac": "XP_005155463", "gene_names_uniprotkb": "bmp1b", "gene_names_refseq": "bmp1b", "protein_names_uniprotkb": "Metalloendopeptidase; 3.4.24.-", "protein_names_refseq": "bone morphogenetic protein 1b isoform X1", "tax_id": 7955, "disease": "osteogenesis imperfecta type 13 (Disease Ontology:DOID:0110342)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1Y0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1Y9-1", "uniprot_id": "A0A8M2B1Y9_DANRE", "mass": 54334.0, "length": 488, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "mknk1", "organism": "Zebrafish", "refseq_name": "MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1", "refseq_ac": "XP_005156012", "gene_names_uniprotkb": "mknk1; zgc:171912", "gene_names_refseq": "mknk1; zgc:171912", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:555974)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "26469318;26846883;27189481;28024160;28381614", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005156012.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B1Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B230-1", "uniprot_id": "A0A8M2B230_DANRE", "mass": 62762.0, "length": 560, "protein_name": "UTP--glucose-1-phosphate uridylyltransferase", "gene_name": "ugp2a", "organism": "Zebrafish", "refseq_name": "UDP-glucose pyrophosphorylase 2a isoform X1", "refseq_ac": "XP_005155455", "gene_names_uniprotkb": "ugp2a; si:ch73-233a22.2", "gene_names_refseq": "si:ch73-233a22.2; ugp2a", "protein_names_uniprotkb": "UTP--glucose-1-phosphate uridylyltransferase; 2.7.7.9", "protein_names_refseq": "UDP-glucose pyrophosphorylase 2a isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 83 (Disease Ontology:DOID:0112218); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:555748)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "26469318;27189481;28252024;31820119;35474468;36290180", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005155455.3. COMPLETENESS: full length., [RefSeq]; UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.9", "go_molecular_function": "GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0008345 larval locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B264-1", "uniprot_id": "A0A8M2B264_DANRE", "mass": 24681.0, "length": 217, "protein_name": "Ataxin-7-like protein 3", "gene_name": "atxn7l3b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005156149", "gene_names_uniprotkb": "atxn7l3b; ATXN7L3; fm52d09; si:dkeyp-118b1.2; wu:fm52d09", "gene_names_refseq": "atxn7l3b; fm52d09; si:dkeyp-118b1.2; wu:fm52d09", "protein_names_uniprotkb": "Ataxin-7-like protein 3; SAGA-associated factor 11 homolog", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559983)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0071819 DUBm complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2B264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2A8-1", "uniprot_id": "A0A8M2B2A8_DANRE", "mass": 51849.0, "length": 475, "protein_name": "Protein phosphatase 1B", "gene_name": "ppm1bb", "organism": "Zebrafish", "refseq_name": "protein phosphatase 1bb isoform X1", "refseq_ac": "XP_005156321", "gene_names_uniprotkb": "ppm1bb; fc18g04; ppm1a; wu:fc18g04; zgc:92329", "gene_names_refseq": "fc18g04; ppm1a; ppm1bb; wu:fc18g04; zgc:92329", "protein_names_uniprotkb": "Protein phosphatase 1B; 3.1.3.16; Protein phosphatase 2C isoform beta", "protein_names_refseq": "protein phosphatase 1bb isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2A8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2U8-1", "uniprot_id": "A0A8M2B2U8_DANRE", "mass": 42733.0, "length": 387, "protein_name": "Paralemmin-1", "gene_name": "palm1a", "organism": "Zebrafish", "refseq_name": "paralemmin 1a isoform X1", "refseq_ac": "XP_005156008", "gene_names_uniprotkb": "palm1a; palm; zgc:110136", "gene_names_refseq": "palm1a; palm; zgc:110136", "protein_names_uniprotkb": "Paralemmin-1; Paralemmin", "protein_names_refseq": "paralemmin 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0043197 dendritic spine;GO:0098794 postsynapse;GO:0030175 filopodium", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008360 regulation of cell shape;GO:0051491 positive regulation of filopodium assembly;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3B8-1", "uniprot_id": "A0A8M2B3B8_DANRE", "mass": 122873.0, "length": 1099, "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 3", "gene_name": "eif2ak3", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 3", "refseq_ac": "XP_005156642", "gene_names_uniprotkb": "eif2ak3", "gene_names_refseq": "eif2ak3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 3; 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Protein tyrosine kinase EIF2AK3", "protein_names_refseq": "eukaryotic translation initiation factor 2-alpha kinase 3", "tax_id": 7955, "disease": "Wolcott-Rallison syndrome (Disease Ontology:DOID:0090060); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:559564)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005156642.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.10.2;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0001666 response to hypoxia;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3G5-1", "uniprot_id": "A0A8M2B3G5_DANRE", "mass": 44339.0, "length": 387, "protein_name": "LIM domain-binding protein 2a isoform X1", "gene_name": "ldb2a", "organism": "Zebrafish", "refseq_name": "LIM domain-binding protein 2a isoform X1", "refseq_ac": "XP_005157399", "gene_names_uniprotkb": "ldb2a; ldb2", "gene_names_refseq": "ldb2a; ldb2", "protein_names_uniprotkb": "LIM domain-binding protein 2a isoform X1", "protein_names_refseq": "LIM domain-binding protein 2a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005157399.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0030274 LIM domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1900108 negative regulation of nodal signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3R2-1", "uniprot_id": "A0A8M2B3R2_DANRE", "mass": 192421.0, "length": 1684, "protein_name": "Clathrin heavy chain", "gene_name": "cltcb", "organism": "Zebrafish", "refseq_name": "clathrin heavy chain 1 isoform X1", "refseq_ac": "XP_005157481", "gene_names_uniprotkb": "cltcb; fd07f11; im:7145213; wu:fd07f11; zgc:113234", "gene_names_refseq": "cltcb; fd07f11; im:7145213; wu:fd07f11; zgc:113234", "protein_names_uniprotkb": "Clathrin heavy chain", "protein_names_refseq": "clathrin heavy chain 1 isoform X1", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 56 (Disease Ontology:DOID:0080226)", "pathway": " (dre:503600)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;18335061;26469318;28252024;30224808;36078102", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0030130 clathrin coat of trans-Golgi network vesicle;GO:0071439 clathrin complex;GO:0030132 clathrin coat of coated pit", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B3R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3W7-1", "uniprot_id": "A0A8M2B3W7_DANRE", "mass": 39691.0, "length": 362, "protein_name": "Porphobilinogen deaminase", "gene_name": "hmbsb", "organism": "Zebrafish", "refseq_name": "hydroxymethylbilane synthase, b isoform X1", "refseq_ac": "XP_005157626", "gene_names_uniprotkb": "hmbsb; PBGD; hmbsl; id:ibd5004; im:7140060; zgc:110690", "gene_names_refseq": "PBGD; hmbsb; hmbsl; id:ibd5004; im:7140060; zgc:110690", "protein_names_uniprotkb": "Porphobilinogen deaminase; 2.5.1.61; Hydroxymethylbilane synthase", "protein_names_refseq": "hydroxymethylbilane synthase, b isoform X1", "tax_id": 7955, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); cancer (Disease Ontology:DOID:162); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); seminoma (Disease Ontology:DOID:4440); liver carcinoma (Disease Ontology:DOID:686)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.61", "go_molecular_function": "GO:0004418 hydroxymethylbilane synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3W7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B416-1", "uniprot_id": "A0A8M2B416_DANRE", "mass": 36526.0, "length": 332, "protein_name": "PDZ and LIM domain protein 3", "gene_name": "pdlim3b", "organism": "Zebrafish", "refseq_name": "PDZ and LIM domain protein 3b isoform X1", "refseq_ac": "XP_005157291", "gene_names_uniprotkb": "pdlim3b; alp; hm:zeh1190; pdlim3; sb:eu571", "gene_names_refseq": "alp; hm:zeh1190; pdlim3b; pdlim3; sb:eu571", "protein_names_uniprotkb": "PDZ and LIM domain protein 3", "protein_names_refseq": "PDZ and LIM domain protein 3b isoform X1", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005157291.1. COMPLETENESS: full length., [RefSeq]; May play a role in the organization of actin filament arrays within muscle cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0031941 filamentous actin", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B481-1", "uniprot_id": "A0A8M2B481_DANRE", "mass": 317245.0, "length": 2874, "protein_name": "Breast cancer type 2 susceptibility protein", "gene_name": "brca2", "organism": "Zebrafish", "refseq_name": "breast cancer type 2 susceptibility protein", "refseq_ac": "NP_001103864", "gene_names_uniprotkb": "brca2; fancd1", "gene_names_refseq": "brca2; fancd1", "protein_names_uniprotkb": "Breast cancer type 2 susceptibility protein", "protein_names_refseq": "breast and ovarian cancer susceptibility protein 2; breast cancer 2, early onset; breast cancer type 2 susceptibility protein", "tax_id": 7955, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); Fanconi anemia complementation group D1 (Disease Ontology:DOID:0111089); prostate cancer (Disease Ontology:DOID:10283); atrophy of testis (Disease Ontology:DOID:11994); Fanconi anemia (Disease Ontology:DOID:13636); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); infertility (Disease Ontology:DOID:5223); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683); endometrial serous adenocarcinoma (Disease Ontology:DOID:5750); uveal melanoma (Disease Ontology:DOID:6039); cataract (Disease Ontology:DOID:83); skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:566758); (R-DRE-5685939); (R-DRE-5685942); (R-DRE-5693537); (R-DRE-5693568); (R-DRE-5693579); (R-DRE-5693616)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "16515849;19101574;20974951;21483806;24489863;33378672;34010734;34390914;35042909;36208295", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF088196.1, BC171710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705, SAMN06350654 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On Aug 6, 2010 this sequence version replaced NP_001103864.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury. Publication Status: Online-Only, [RefSeq, PubMed]; Carcinogenesis in zebrafish with combined mutations in tp53 and brca2 typically requires biallelic mutation or loss of at least one of these genes. Publication Status: Online-Only, [RefSeq, PubMed]; Critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues, [RefSeq, PubMed]; The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R8E8", "ec_number_list": "", "go_molecular_function": "GO:0003697 single-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007530 sex determination;GO:0007283 spermatogenesis;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4I2-1", "uniprot_id": "A0A8M2B4I2_DANRE", "mass": 274374.0, "length": 2342, "protein_name": "Pre-mRNA-processing-splicing factor 8", "gene_name": "prpf8", "organism": "Zebrafish", "refseq_name": "pre-mRNA-processing-splicing factor 8", "refseq_ac": "NP_957270", "gene_names_uniprotkb": "prpf8; id:ibd1257; ik:tdsubc_2a9; im:7141966; tdsubc_2a9; wu:fb37c02; wu:fb73e06; xx:tdsubc_2a9; zgc:56504", "gene_names_refseq": "id:ibd1257; ik:tdsubc_2a9; im:7141966; prpf8; tdsubc_2a9; wu:fb37c02; wu:fb73e06; xx:tdsubc_2a9; zgc:56504", "protein_names_uniprotkb": "Pre-mRNA-processing-splicing factor 8; Splicing factor Prp8", "protein_names_refseq": "pre-mRNA-processing-splicing factor 8", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); retinitis pigmentosa 13 (Disease Ontology:DOID:0110403); prostate cancer (Disease Ontology:DOID:10283); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:393951); (R-DRE-72163); (R-DRE-72165)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "20040115;23714367;24419317;26137319;26469318;32703943;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01031529.1, GDQH01000188.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Mar 12, 2008 this sequence version replaced XP_699626.2, NP_957270.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site., [UniProtKB, UniProtKB]; Within early haematopoiesis, myeloid differentiation is impaired, suggesting Prpf8 is required for haematopoietic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J8E6", "ec_number_list": "", "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030620 U2 snRNA binding;GO:0008237 metallopeptidase activity;GO:0030619 U1 snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0005682 U5 snRNP", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2B4I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4M5-1", "uniprot_id": "A0A8M2B4M5_DANRE", "mass": 142044.0, "length": 1294, "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "scap", "organism": "Zebrafish", "refseq_name": "sterol regulatory element-binding protein cleavage-activating protein isoform X1", "refseq_ac": "XP_005158307", "gene_names_uniprotkb": "scap", "gene_names_refseq": "scap", "protein_names_uniprotkb": "Sterol regulatory element-binding protein cleavage-activating protein", "protein_names_refseq": "sterol regulatory element-binding protein cleavage-activating protein isoform X1", "tax_id": 7955, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dre:558292)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0032936 SREBP-SCAP complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0019915 lipid storage;GO:0032933 SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5G2-1", "uniprot_id": "A0A8M2B5G2_DANRE", "mass": 106435.0, "length": 933, "protein_name": "non-specific protein-tyrosine kinase", "gene_name": "ptk2ba", "organism": "Zebrafish", "refseq_name": "protein-tyrosine kinase 2-beta isoform X1", "refseq_ac": "XP_005158634", "gene_names_uniprotkb": "ptk2ba", "gene_names_refseq": "ptk2ba", "protein_names_uniprotkb": "non-specific protein-tyrosine kinase; 2.7.10.2", "protein_names_refseq": "protein-tyrosine kinase 2-beta isoform X1", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); diabetic angiopathy (Disease Ontology:DOID:11713); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)", "pathway": " (dre:557258); (R-DRE-4420097); (R-DRE-9013420); (R-DRE-9020558)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HQD3;K7DYJ3", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.11.1;2.7.12.1;2.7.12.2;2.3.2.26", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0042995 cell projection", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0007172 signal complex assembly;GO:0030155 regulation of cell adhesion;GO:0030335 positive regulation of cell migration;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5B6-1", "uniprot_id": "A0A8M2B5B6_DANRE", "mass": 286106.0, "length": 2481, "protein_name": "Spectrin beta chain", "gene_name": "sptb", "organism": "Zebrafish", "refseq_name": "spectrin beta chain, erythrocytic isoform X1", "refseq_ac": "XP_005158906", "gene_names_uniprotkb": "sptb; fa09g12; wu:fa09g12", "gene_names_refseq": "fa09g12; sptb; wu:fa09g12", "protein_names_uniprotkb": "Spectrin beta chain", "protein_names_refseq": "spectrin beta chain, erythrocytic isoform X1", "tax_id": 7955, "disease": "spinocerebellar ataxia 5 (Disease Ontology:DOID:0050882); hereditary spherocytosis type 2 (Disease Ontology:DOID:0110917); hereditary spherocytosis (Disease Ontology:DOID:12971)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005543 phospholipid binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0014731 spectrin-associated cytoskeleton;GO:0030864 cortical actin cytoskeleton;GO:0042995 cell projection", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0030036 actin cytoskeleton organization;GO:0051693 actin filament capping;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5N2-1", "uniprot_id": "TSN18_DANRE", "mass": 28901.0, "length": 258, "protein_name": "Tetraspanin-18B", "gene_name": "tspan18b", "organism": "Zebrafish", "refseq_name": "tetraspanin-18B", "refseq_ac": "NP_001002439", "gene_names_uniprotkb": "tspan18b; zgc:92637", "gene_names_refseq": "tspan18b; zgc:92637", "protein_names_uniprotkb": "Tetraspanin-18B", "protein_names_refseq": "tetraspanin-18B", "tax_id": 7955, "disease": "", "pathway": " (dre:436712)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;26469318;31097478;32694189", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042140.1, GDQH01020823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On or before Jun 17, 2024 this sequence version replaced XP_005159229.1, NP_001002439.1., [RefSeq]; May regulate angiogenesis through KDR/VEGFR2 and NOTCH1 pathways., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KQH0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045765 regulation of angiogenesis;GO:1903670 regulation of sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B5N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5P8-1", "uniprot_id": "A0A8M2B5P8_DANRE", "mass": 78362.0, "length": 680, "protein_name": "Receptor-type tyrosine-protein phosphatase", "gene_name": "ptpreb", "organism": "Zebrafish", "refseq_name": "protein tyrosine phosphatase receptor type Eb isoform X1", "refseq_ac": "XP_005158846", "gene_names_uniprotkb": "ptpreb; si:dkey-46n18.4", "gene_names_refseq": "ptpreb; si:dkey-46n18.4", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase; 3.1.3.48", "protein_names_refseq": "protein tyrosine phosphatase receptor type Eb isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569164)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20188722;20838449;23974070;25147559;26469318;27189481;27615194;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005158846.1. COMPLETENESS: full length., [RefSeq]; Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0060027 convergent extension involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2B5P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5Y7-1", "uniprot_id": "A0A8M2B5Y7_DANRE", "mass": 62675.0, "length": 575, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 5", "gene_name": "slc2a3a", "organism": "Zebrafish", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 3a isoform X1", "refseq_ac": "XP_005159482", "gene_names_uniprotkb": "slc2a3a; glut3a; slc2a3; wu:fb92c06; zgc:92476", "gene_names_refseq": "glut3a; slc2a3a; slc2a3; wu:fb92c06; zgc:92476", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine", "protein_names_refseq": "solute carrier family 2, facilitated glucose transporter member 3a isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); acanthosis nigricans (Disease Ontology:DOID:3138); cataract (Disease Ontology:DOID:83); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:0007420 brain development;GO:0032868 response to insulin;GO:1990539 fructose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5Y7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6T0-1", "uniprot_id": "A0A8M2B6T0_DANRE", "mass": 38925.0, "length": 354, "protein_name": "Forkhead box protein E1", "gene_name": "foxe1", "organism": "Zebrafish", "refseq_name": "forkhead box protein E1", "refseq_ac": "XP_005159967", "gene_names_uniprotkb": "foxe1", "gene_names_refseq": "foxe1", "protein_names_uniprotkb": "Forkhead box protein E1", "protein_names_refseq": "forkhead box protein E1", "tax_id": 7955, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); Bamforth-Lazarus syndrome (Disease Ontology:DOID:0050655); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (dre:567676)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005159967.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1903010 regulation of bone development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6W2-1", "uniprot_id": "A0A8M2B6W2_DANRE", "mass": 72233.0, "length": 651, "protein_name": "Beta-galactosidase", "gene_name": "glb1", "organism": "Zebrafish", "refseq_name": "beta-galactosidase precursor", "refseq_ac": "NP_001017547", "gene_names_uniprotkb": "glb1; zgc:110823", "gene_names_refseq": "glb1; zgc:110823", "protein_names_uniprotkb": "Beta-galactosidase; 3.2.1.23", "protein_names_refseq": "beta-galactosidase precursor; beta-galactosidase", "tax_id": 7955, "disease": "GM1 gangliosidosis type 3 (Disease Ontology:DOID:0080489); GM1 gangliosidosis type 2 (Disease Ontology:DOID:0080501); GM1 gangliosidosis type 1 (Disease Ontology:DOID:0080502); mucopolysaccharidosis type IVB (Disease Ontology:DOID:0111392); mucopolysaccharidosis IV (Disease Ontology:DOID:12804); GM1 gangliosidosis (Disease Ontology:DOID:3322)", "pathway": " (dre:548343)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.2984017.1, SRR32588733.1669593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Jul 8, 2025 this sequence version replaced XP_005160189.3, NP_001017547.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004565 beta-galactosidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0005764 lysosome;GO:0005773 vacuole", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0019388 galactose catabolic process;GO:0042340 keratan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6W9-1", "uniprot_id": "A0A8M2B6W9_DANRE", "mass": 107661.0, "length": 951, "protein_name": "protein kinase C", "gene_name": "pkn1a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase N1 isoform X1", "refseq_ac": "XP_005160107", "gene_names_uniprotkb": "pkn1a", "gene_names_refseq": "pkn1a", "protein_names_uniprotkb": "protein kinase C; 2.7.11.13", "protein_names_refseq": "serine/threonine-protein kinase N1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:560840)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_005160107.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032154 cleavage furrow;GO:0030496 midbody", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW18-1", "uniprot_id": "ATP2A_DANRE", "mass": 109504.0, "length": 996, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2a", "gene_name": "atp2a2a", "organism": "Zebrafish", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2a", "refseq_ac": "NP_957259", "gene_names_uniprotkb": "atp2a2a; atp2a2; zgc:55380", "gene_names_refseq": "atp2a2a; atp2a2; zgc:55380", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2a; 7.2.2.10; SERCA2", "protein_names_refseq": "ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; serca2", "tax_id": 7955, "disease": "acrokeratosis verruciformis (Disease Ontology:DOID:0050606); Brody myopathy (Disease Ontology:DOID:0050692); essential hypertension (Disease Ontology:DOID:10825); heart disease (Disease Ontology:DOID:114); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); hypothyroidism (Disease Ontology:DOID:1459); keratosis follicularis (Disease Ontology:DOID:2734); euthyroid sick syndrome (Disease Ontology:DOID:2856); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:393940)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16314582;23594743;35829917;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045327.1. On Jul 6, 2005 this sequence version replaced XP_702421.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:35829917). Involved in the regulation of cardiac contractility (PubMed:16314582). Involved in autophagy in response to starvation. Controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0048742 regulation of skeletal muscle fiber development;GO:0008016 regulation of heart contraction;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7ZW18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA19-1", "uniprot_id": "A0A8M2BA19_DANRE", "mass": 163582.0, "length": 1439, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "tnikb", "organism": "Zebrafish", "refseq_name": "TRAF2 and NCK interacting kinase b isoform X1", "refseq_ac": "XP_005162835", "gene_names_uniprotkb": "tnikb; im:6898857; zgc:123033; zgc:152783", "gene_names_refseq": "im:6898857; tnikb; zgc:123033; zgc:152783", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "TRAF2 and NCK interacting kinase b isoform X1", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 54 (Disease Ontology:DOID:0081216); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:556959)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;21822242;25504979;26469318;27189481;28252024;30082412", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162835.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2BA19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBJ6-1", "uniprot_id": "A0A8M2BBJ6_DANRE", "mass": 86484.0, "length": 773, "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "hgs", "organism": "Zebrafish", "refseq_name": "hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1", "refseq_ac": "XP_005164430", "gene_names_uniprotkb": "hgs; fi34f05; wu:fi34f05; zgc:63492", "gene_names_refseq": "fi34f05; hgs; wu:fi34f05; zgc:63492", "protein_names_uniprotkb": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "protein_names_refseq": "hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:334175)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21468032;26469318;27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding;GO:0016301 kinase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0031901 early endosome membrane;GO:0032585 multivesicular body membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BBJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDG0-1", "uniprot_id": "A0A8M2BDG0_DANRE", "mass": 309449.0, "length": 2711, "protein_name": "Inositol 1,4,5-trisphosphate receptor", "gene_name": "itpr1a", "organism": "Zebrafish", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1", "refseq_ac": "XP_005166152", "gene_names_uniprotkb": "itpr1a", "gene_names_refseq": "itpr1a", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1", "tax_id": 7955, "disease": "spinocerebellar ataxia 15 (Disease Ontology:DOID:0050965); spinocerebellar ataxia 29 (Disease Ontology:DOID:0050978); cardiac arrest (Disease Ontology:DOID:0060319); Gillespie syndrome (Disease Ontology:DOID:0111578); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); Huntington's disease (Disease Ontology:DOID:12858); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:567611)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE23-1", "uniprot_id": "A0A8M2BE23_DANRE", "mass": 50584.0, "length": 435, "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 3 isoform X1", "gene_name": "pacsin3", "organism": "Zebrafish", "refseq_name": "protein kinase C and casein kinase substrate in neurons protein 3 isoform X1", "refseq_ac": "XP_005166650", "gene_names_uniprotkb": "pacsin3; Pacsin1; fa11d03; fj67e09; wu:fa11d03; wu:fj67e09; wu:fq16a06; zgc:56324", "gene_names_refseq": "Pacsin1; fa11d03; fj67e09; pacsin3; wu:fa11d03; wu:fj67e09; wu:fq16a06; zgc:56324", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons protein 3 isoform X1", "protein_names_refseq": "protein kinase C and casein kinase substrate in neurons protein 3 isoform X1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58FY13;A0AC58FY42;B0R118", "ec_number_list": "", "go_molecular_function": "GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0014028 notochord formation;GO:0060034 notochord cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BE23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BG85-1", "uniprot_id": "A0A8M2BG85_DANRE", "mass": 190661.0, "length": 1722, "protein_name": "Zona occludens protein 1", "gene_name": "tjp1a", "organism": "Zebrafish", "refseq_name": "tight junction protein 1 isoform X1", "refseq_ac": "XP_005168990", "gene_names_uniprotkb": "tjp1a", "gene_names_refseq": "tjp1a", "protein_names_uniprotkb": "Zona occludens protein 1; Zonula occludens protein 1", "protein_names_refseq": "tight junction protein 1 isoform X1", "tax_id": 7955, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); uveitis (Disease Ontology:DOID:13141); cholestasis (Disease Ontology:DOID:13580); peptic esophagitis (Disease Ontology:DOID:13976); brain ischemia (Disease Ontology:DOID:2316); bile duct cancer (Disease Ontology:DOID:4606); gallbladder carcinoma (Disease Ontology:DOID:4948); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); brain disease (Disease Ontology:DOID:936)", "pathway": " (dre:378845)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168990.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0005921 gap junction", "go_biological_process": "GO:0036060 slit diaphragm assembly;GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BG85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAR0-1", "uniprot_id": "A0A8M2BAR0_DANRE", "mass": 173359.0, "length": 1533, "protein_name": "Glycogen debranching enzyme", "gene_name": "agla", "organism": "Zebrafish", "refseq_name": "glycogen debranching enzyme isoform X2", "refseq_ac": "XP_005163674", "gene_names_uniprotkb": "agla; agl; si:ch211-153l6.1", "gene_names_refseq": "agla; agl; si:ch211-153l6.1", "protein_names_uniprotkb": "Glycogen debranching enzyme; 2.4.1.25; 3.2.1.33; Glycogen debrancher", "protein_names_refseq": "glycogen debranching enzyme isoform X2", "tax_id": 7955, "disease": "glycogen storage disease III (Disease Ontology:DOID:2748); uremia (Disease Ontology:DOID:4676); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (dre:567798)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25840430;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H2D0;A0AC58H2D8;A0AC58H2E0;A0AC58H2E3;A0AC58H2E4", "ec_number_list": "", "go_molecular_function": "GO:0004134 4-alpha-glucanotransferase activity;GO:0004135 amylo-alpha-1,6-glucosidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005978 glycogen biosynthetic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BAR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAV5-1", "uniprot_id": "A0A8M2BAV5_DANRE", "mass": 61148.0, "length": 549, "protein_name": "BAR/IMD domain-containing adapter protein 2", "gene_name": "baiap2a", "organism": "Zebrafish", "refseq_name": "brain-specific angiogenesis inhibitor 1-associated protein 2a isoform X1", "refseq_ac": "XP_005163812", "gene_names_uniprotkb": "baiap2a; wu:fk29g02; zgc:136827", "gene_names_refseq": "baiap2a; wu:fk29g02; zgc:136827", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2", "protein_names_refseq": "brain-specific angiogenesis inhibitor 1-associated protein 2a isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119)", "pathway": " (dre:678518)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "25875301;26461441;26469318;28252024;29190094;29258003;31002663;32692463;35225788;36791723;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005163812.1. COMPLETENESS: full length., [RefSeq]; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0030175 filopodium;GO:0001726 ruffle;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0030182 neuron differentiation;GO:0051017 actin filament bundle assembly;GO:0051764 actin crosslink formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M2BAV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJX0-1", "uniprot_id": "A0A8M3AJX0_DANRE", "mass": 286268.0, "length": 2585, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "hectd1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase HECTD1 isoform X1", "refseq_ac": "XP_009291386", "gene_names_uniprotkb": "hectd1; si:dz142b24.4; wu:fc30d02; wu:fc49f09; wu:fd99d04; zgc:123053; zgc:92832", "gene_names_refseq": "hectd1; si:dz142b24.4; wu:fc30d02; wu:fc49f09; wu:fd99d04; zgc:123053; zgc:92832", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.26", "protein_names_refseq": "E3 ubiquitin-protein ligase HECTD1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100002034)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;26469318;27189481;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009291386.1. COMPLETENESS: full length., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3AJX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AK57-1", "uniprot_id": "A0A8M3AK57_DANRE", "mass": 44947.0, "length": 409, "protein_name": "Homeobox protein Meis2a isoform X1", "gene_name": "meis2a", "organism": "Zebrafish", "refseq_name": "homeobox protein Meis2a isoform X1", "refseq_ac": "XP_009291615", "gene_names_uniprotkb": "meis2a; fa26d08; meis2.2; wu:fa26d08", "gene_names_refseq": "fa26d08; meis2.2; meis2a; wu:fa26d08", "protein_names_uniprotkb": "Homeobox protein Meis2a isoform X1", "protein_names_refseq": "homeobox protein Meis2a isoform X1", "tax_id": 7955, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); orofacial cleft (Disease Ontology:DOID:0050567); cleft palate, cardiac defects, and intellectual disability (Disease Ontology:DOID:0111697); open-angle glaucoma (Disease Ontology:DOID:1067); leukemia (Disease Ontology:DOID:1240); brain infarction (Disease Ontology:DOID:3454); cleft palate (Disease Ontology:DOID:674); learning disability (Disease Ontology:DOID:8927)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HM05", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0048703 embryonic viscerocranium morphogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AK57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B770-1", "uniprot_id": "A0A8M2B770_DANRE", "mass": 80492.0, "length": 724, "protein_name": "Poly(A) polymerase", "gene_name": "papola", "organism": "Zebrafish", "refseq_name": "poly(A) polymerase alpha isoform X1", "refseq_ac": "XP_005160406", "gene_names_uniprotkb": "papola; papolb; si:ch211-199l3.6; wu:fc43b06; wu:fp01g10; zgc:109706", "gene_names_refseq": "papola; papolb; si:ch211-199l3.6; wu:fc43b06; wu:fp01g10; zgc:109706", "protein_names_uniprotkb": "Poly(A) polymerase; 2.7.7.19", "protein_names_refseq": "poly(A) polymerase alpha isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:404041)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;26469318;26767746;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005160406.1. COMPLETENESS: full length., [RefSeq]; Polymerase that creates the 3'-poly(A) tail of mRNA's., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.19;2.7.7.52", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B770-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEF7-1", "uniprot_id": "A0A8M2BEF7_DANRE", "mass": 99667.0, "length": 888, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "edem3", "organism": "Zebrafish", "refseq_name": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1", "refseq_ac": "XP_005166989", "gene_names_uniprotkb": "edem3", "gene_names_refseq": "edem3", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1", "tax_id": 7955, "disease": "congenital disorder of glycosylation type IIv (Disease Ontology:DOID:0051050); cystic fibrosis (Disease Ontology:DOID:1485)", "pathway": " (dre:559811)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005166989.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:1904380 endoplasmic reticulum mannose trimming;GO:0006986 response to unfolded protein;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLA1-1", "uniprot_id": "A0A8M2BLA1_DANRE", "mass": 118649.0, "length": 1070, "protein_name": "Semaphorin-6D isoform X1", "gene_name": "sema6d", "organism": "Zebrafish", "refseq_name": "semaphorin-6D isoform X1", "refseq_ac": "XP_073785194", "gene_names_uniprotkb": "sema6d; sema6dl; si:ch211-278n20.1; zgc:112012", "gene_names_refseq": "sema6dl; sema6d; si:ch211-278n20.1; zgc:112012", "protein_names_uniprotkb": "Semaphorin-6D isoform X1", "protein_names_refseq": "semaphorin-6D isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HT80", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7D6-1", "uniprot_id": "A0A8M2B7D6_DANRE", "mass": 90864.0, "length": 806, "protein_name": "Anaphase-promoting complex subunit 4", "gene_name": "anapc4", "organism": "Zebrafish", "refseq_name": "anaphase-promoting complex subunit 4 isoform X1", "refseq_ac": "XP_005160577", "gene_names_uniprotkb": "anapc4; si:dkey-90m5.2; zgc:101872", "gene_names_refseq": "anapc4; si:dkey-90m5.2; zgc:101872", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 4; Cyclosome subunit 4", "protein_names_refseq": "anaphase-promoting complex subunit 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:494046)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0030071 regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B7D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFL2-1", "uniprot_id": "A0A8M2BFL2_DANRE", "mass": 42307.0, "length": 388, "protein_name": "Muscleblind-like protein 2 isoform X1", "gene_name": "mbnl2", "organism": "Zebrafish", "refseq_name": "muscleblind-like protein 2 isoform 1", "refseq_ac": "NP_001428758", "gene_names_uniprotkb": "mbnl2; fj89c04; wu:fj89c04", "gene_names_refseq": "fj89c04; mbnl2; wu:fj89c04", "protein_names_uniprotkb": "Muscleblind-like protein 2 isoform X1", "protein_names_refseq": "muscleblind-like 2; muscleblind-like protein 2 isoform 1", "tax_id": 7955, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450)", "pathway": " (dre:560384)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18606240;21303839;21468032;26469318;27189481;30818081;34125183;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588719.10205796.1, SRR32588729.16521404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505378, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jul 8, 2025 this sequence version replaced XP_005168353.1., [RefSeq]; MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the myotonic dystrophy phenotype., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J713;A0AC58J718", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0007507 heart development;GO:0007517 muscle organ development;GO:0008380 RNA splicing;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BFL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B959-1", "uniprot_id": "A0A8M2B959_DANRE", "mass": 60913.0, "length": 534, "protein_name": "Glucose-6-phosphate 1-dehydrogenase", "gene_name": "g6pd", "organism": "Zebrafish", "refseq_name": "glucose-6-phosphate 1-dehydrogenase isoform X1", "refseq_ac": "XP_005162067", "gene_names_uniprotkb": "g6pd", "gene_names_refseq": "g6pd", "protein_names_uniprotkb": "Glucose-6-phosphate 1-dehydrogenase; 1.1.1.49", "protein_names_refseq": "glucose-6-phosphate 1-dehydrogenase isoform X1", "tax_id": 7955, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nonspherocytic hemolytic anemia 1 (Disease Ontology:DOID:0051003); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); malaria (Disease Ontology:DOID:12365); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); favism (Disease Ontology:DOID:13628); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); renovascular hypertension (Disease Ontology:DOID:1591); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); neonatal jaundice (Disease Ontology:DOID:2383); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); kidney disease (Disease Ontology:DOID:557); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); hyperhomocysteinemia (Disease Ontology:DOID:9279); phenylketonuria (Disease Ontology:DOID:9281); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:570579)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.49", "go_molecular_function": "GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0050661 NADP binding;GO:0003979 UDP-glucose 6-dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035886 vascular associated smooth muscle cell differentiation;GO:0006098 pentose-phosphate shunt;GO:0006006 glucose metabolic process;GO:0090504 epiboly;GO:0009051 pentose-phosphate shunt, oxidative branch", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B959-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B939-1", "uniprot_id": "A0A8M2B939_DANRE", "mass": 169660.0, "length": 1531, "protein_name": "Arginine-glutamic acid dipeptide repeats protein", "gene_name": "rerea", "organism": "Zebrafish", "refseq_name": "arginine-glutamic acid dipeptide repeats protein isoform X1", "refseq_ac": "XP_005162258", "gene_names_uniprotkb": "rerea", "gene_names_refseq": "rerea", "protein_names_uniprotkb": "Arginine-glutamic acid dipeptide repeats protein", "protein_names_refseq": "arginine-glutamic acid dipeptide repeats protein isoform X1", "tax_id": 7955, "disease": "dentatorubral-pallidoluysian atrophy (Disease Ontology:DOID:0060162)", "pathway": " (dre:569081)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58ILD3;A0AC58ILD8;E7F226", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding;GO:0001222 transcription corepressor binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0061386 closure of optic fissure;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0060037 pharyngeal system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B939-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIN3-1", "uniprot_id": "A0A8M2BIN3_DANRE", "mass": 167062.0, "length": 1486, "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "rapgef2a", "organism": "Zebrafish", "refseq_name": "rap guanine nucleotide exchange factor 2 isoform X1", "refseq_ac": "XP_005170987", "gene_names_uniprotkb": "rapgef2a", "gene_names_refseq": "rapgef2a", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 2; Cyclic nucleotide ras GEF; Neural RAP guanine nucleotide exchange protein; PDZ domain-containing guanine nucleotide exchange factor 1; RA-GEF-1; Ras/Rap1-associating GEF-1", "protein_names_refseq": "rap guanine nucleotide exchange factor 2 isoform X1", "tax_id": 7955, "disease": "familial adult myoclonic epilepsy 7 (Disease Ontology:DOID:0111694)", "pathway": " (dre:793952)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005170987.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome;GO:0070161 anchoring junction;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007264 small GTPase-mediated signal transduction;GO:0032486 Rap protein signal transduction;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBT8-1", "uniprot_id": "A0A8M2BBT8_DANRE", "mass": 43872.0, "length": 389, "protein_name": "mitogen-activated protein kinase kinase", "gene_name": "map2k4a", "organism": "Zebrafish", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 4a isoform X2", "refseq_ac": "XP_005164412", "gene_names_uniprotkb": "map2k4a; MKK4A-l; MKK4; map2k4; zgc:136500", "gene_names_refseq": "MKK4A-l; MKK4; map2k4a; map2k4; zgc:136500", "protein_names_uniprotkb": "mitogen-activated protein kinase kinase; 2.7.12.2", "protein_names_refseq": "dual specificity mitogen-activated protein kinase kinase 4a isoform X2", "tax_id": 7955, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ovarian serous carcinoma (Disease Ontology:DOID:0050933); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005164412.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.10.2;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0033554 cellular response to stress;GO:0048263 determination of dorsal identity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJ68-1", "uniprot_id": "A0A8M3AJ68_DANRE", "mass": 117114.0, "length": 1069, "protein_name": "Interphotoreceptor matrix proteoglycan 1", "gene_name": "impg1b", "organism": "Zebrafish", "refseq_name": "interphotoreceptor matrix proteoglycan 1 isoform X1", "refseq_ac": "XP_009291488", "gene_names_uniprotkb": "impg1b", "gene_names_refseq": "impg1b", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 1; Sialoprotein associated with cones and rods", "protein_names_refseq": "interphotoreceptor matrix proteoglycan 1 isoform X1", "tax_id": 7955, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); retinitis pigmentosa 91 (Disease Ontology:DOID:0061106)", "pathway": " (dre:558797)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJ68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJK7-1", "uniprot_id": "A0A8M3AJK7_DANRE", "mass": 81858.0, "length": 741, "protein_name": "Sodium/potassium/calcium exchanger 1", "gene_name": "slc24a1", "organism": "Zebrafish", "refseq_name": "sodium/potassium/calcium exchanger 1 isoform X1", "refseq_ac": "XP_009291877", "gene_names_uniprotkb": "slc24a1", "gene_names_refseq": "slc24a1", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger; Solute carrier family 24 member 1", "protein_names_refseq": "sodium/potassium/calcium exchanger 1 isoform X1", "tax_id": 7955, "disease": "congenital stationary night blindness 1D (Disease Ontology:DOID:0110868)", "pathway": " (dre:558299)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009291877.2. COMPLETENESS: full length., [RefSeq]; Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0015297 antiporter activity;GO:0005262 calcium channel activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007601 visual perception;GO:0070588 calcium ion transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B773-1", "uniprot_id": "A0A8M2B773_DANRE", "mass": 232372.0, "length": 2169, "protein_name": "AT-rich interactive domain-containing protein 1B isoform X1", "gene_name": "arid1b", "organism": "Zebrafish", "refseq_name": "AT-rich interactive domain-containing protein 1B isoform X1", "refseq_ac": "XP_005160411", "gene_names_uniprotkb": "arid1b; fd07d11; si:dkey-60a16.3; wu:fd07d11", "gene_names_refseq": "arid1b; fd07d11; si:dkey-60a16.3; wu:fd07d11", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 1B isoform X1", "protein_names_refseq": "AT-rich interactive domain-containing protein 1B isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Coffin-Siris syndrome 1 (Disease Ontology:DOID:0070042); Coffin-Siris syndrome 2 (Disease Ontology:DOID:0070044); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925); ischemia (Disease Ontology:DOID:326); lung non-small cell carcinoma (Disease Ontology:DOID:3908); kidney disease (Disease Ontology:DOID:557); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (dre:569589)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21865323;24240475;26469318;26767746;36417527;37287661", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005160411.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0016514 SWI/SNF complex;GO:0035060 brahma complex;GO:0005654 nucleoplasm;GO:0071565 nBAF complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0035176 social behavior;GO:0036269 swimming behavior;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBT3-1", "uniprot_id": "A0A8M2BBT3_DANRE", "mass": 178024.0, "length": 1583, "protein_name": "ATP-binding cassette sub-family C member 9 isoform X1", "gene_name": "abcc9", "organism": "Zebrafish", "refseq_name": "ATP-binding cassette sub-family C member 9 isoform X1", "refseq_ac": "XP_005164758", "gene_names_uniprotkb": "abcc9; si:dkey-183c2.3; sur2", "gene_names_refseq": "abcc9; si:dkey-183c2.3; sur2", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 9 isoform X1", "protein_names_refseq": "ATP-binding cassette sub-family C member 9 isoform X1", "tax_id": 7955, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); intellectual disability and myopathy syndrome (Disease Ontology:DOID:0070600); Parkinsonism (Disease Ontology:DOID:0080855); dilated cardiomyopathy 1O (Disease Ontology:DOID:0110451); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:561160)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16124856;16317080;16631343;24836561;25583992;31575858;32831172;34820842;38217872;39021799", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008281 sulfonylurea receptor activity;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008016 regulation of heart contraction;GO:0033198 response to ATP;GO:1904451 regulation of potassium:proton exchanging ATPase activity;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BBT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJU1-1", "uniprot_id": "A0A8M2BJU1_DANRE", "mass": 155757.0, "length": 1424, "protein_name": "Roundabout homolog 3 isoform X1", "gene_name": "robo3", "organism": "Zebrafish", "refseq_name": "roundabout homolog 3 isoform X1", "refseq_ac": "XP_005172693", "gene_names_uniprotkb": "robo3; cb503", "gene_names_refseq": "cb503; robo3", "protein_names_uniprotkb": "Roundabout homolog 3 isoform X1", "protein_names_refseq": "roundabout homolog 3 isoform X1", "tax_id": 7955, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475)", "pathway": " (dre:30770)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15105459;15110042;16033800;16129585;16261616;28252024;29757409;33577748;34473348;35679135", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008046 axon guidance receptor activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0006935 chemotaxis;GO:0016199 axon midline choice point recognition;GO:0007417 central nervous system development;GO:0048264 determination of ventral identity;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BJU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA28-1", "uniprot_id": "A0A8M2BA28_DANRE", "mass": 180738.0, "length": 1814, "protein_name": "Collagen, type XI, alpha 1a isoform X1", "gene_name": "col11a1a", "organism": "Zebrafish", "refseq_name": "collagen, type XI, alpha 1a isoform X1", "refseq_ac": "XP_005162870", "gene_names_uniprotkb": "col11a1a; wu:fb34e11; wu:fc11b03; zgc:158335", "gene_names_refseq": "col11a1a; wu:fb34e11; wu:fc11b03; zgc:158335", "protein_names_uniprotkb": "Collagen, type XI, alpha 1a isoform X1", "protein_names_refseq": "collagen, type XI, alpha 1a isoform X1", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 37 (Disease Ontology:DOID:0070601); Stickler syndrome (Disease Ontology:DOID:0080046); fibrochondrogenesis 1 (Disease Ontology:DOID:0080672); Stickler syndrome 2 (Disease Ontology:DOID:0080675); Marshall syndrome (Disease Ontology:DOID:0111510); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051216 cartilage development;GO:0030903 notochord development;GO:0060536 cartilage morphogenesis;GO:0030199 collagen fibril organization;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLL5-1", "uniprot_id": "A0A8M2BLL5_DANRE", "mass": 59181.0, "length": 518, "protein_name": "Fatty acyl-CoA reductase", "gene_name": "far1", "organism": "Zebrafish", "refseq_name": "fatty acyl-CoA reductase 1 isoform 2", "refseq_ac": "NP_001429320", "gene_names_uniprotkb": "far1; fc22d12; mlstd2; wu:fc22d12; zgc:55416", "gene_names_refseq": "far1; fc22d12; mlstd2; wu:fc22d12; zgc:55416", "protein_names_uniprotkb": "Fatty acyl-CoA reductase; 1.2.1.84", "protein_names_refseq": "fatty acyl-CoA reductase 1 isoform 2; male sterility domain containing 2", "tax_id": 7955, "disease": "rhizomelic chondrodysplasia punctate type 4 (Disease Ontology:DOID:0081243)", "pathway": " (R-DRE-9640463)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588735.2946784.1, SRR32588723.644280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476738 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Aug 4, 2025 this sequence version replaced XP_005174373.1., [RefSeq]; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.84", "go_molecular_function": "GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:1901568 fatty acid derivative metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AHW7-1", "uniprot_id": "A0A8M3AHW7_DANRE", "mass": 64429.0, "length": 591, "protein_name": "Protein tweety homolog", "gene_name": "ttyh1", "organism": "Zebrafish", "refseq_name": "protein tweety homolog 1 isoform X1", "refseq_ac": "XP_009290420", "gene_names_uniprotkb": "ttyh1", "gene_names_refseq": "ttyh1", "protein_names_uniprotkb": "Protein tweety homolog", "protein_names_refseq": "protein tweety homolog 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100537642)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009290420.1. COMPLETENESS: full length., [RefSeq]; Probable chloride channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0072320 volume-sensitive chloride channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex;GO:0030868 smooth endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AHW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B970-1", "uniprot_id": "A0A8M2B970_DANRE", "mass": 52329.0, "length": 469, "protein_name": "Voltage-gated potassium channel subunit beta-1", "gene_name": "kcnab2b", "organism": "Zebrafish", "refseq_name": "voltage-gated potassium channel subunit beta-1-like isoform X1", "refseq_ac": "XP_005162233", "gene_names_uniprotkb": "kcnab2b; zgc:171453", "gene_names_refseq": "kcnab2b; zgc:171453", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1", "protein_names_refseq": "voltage-gated potassium channel subunit beta-1-like isoform X1", "tax_id": 7955, "disease": "chromosome 1p36 deletion syndrome (Disease Ontology:DOID:0060410)", "pathway": " (dre:565014)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24335214;27189481;28252024;33872356;34325655", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.2;1.6.-.-", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005249 voltage-gated potassium channel activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex;GO:0044224 juxtaparanode region of axon;GO:0005856 cytoskeleton", "go_biological_process": "GO:0098900 regulation of action potential;GO:0051969 regulation of transmission of nerve impulse;GO:1901379 regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDH7-1", "uniprot_id": "A0A8M2BDH7_DANRE", "mass": 60926.0, "length": 532, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-3 isoform X2", "gene_name": "gabrb3", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-3 isoform X2", "refseq_ac": "XP_021327485", "gene_names_uniprotkb": "gabrb3", "gene_names_refseq": "gabrb3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-3 isoform X2", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit beta-3 isoform X2", "tax_id": 7955, "disease": "Lennox-Gastaut syndrome (Disease Ontology:DOID:0050561); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 43 (Disease Ontology:DOID:0080447); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:566922); (R-DRE-977443)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7EXG0", "ec_number_list": "", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIF4-1", "uniprot_id": "A0A8M2BIF4_DANRE", "mass": 42408.0, "length": 369, "protein_name": "Lysophosphatidic acid receptor 2b", "gene_name": "lpar2b", "organism": "Zebrafish", "refseq_name": "lysophosphatidic acid receptor 2b", "refseq_ac": "NP_001307062", "gene_names_uniprotkb": "lpar2b; zgc:123246", "gene_names_refseq": "lpar2b; zgc:123246", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 2b", "protein_names_refseq": "lysophosphatidic acid receptor 2b", "tax_id": 7955, "disease": "", "pathway": " (dre:567956)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21971049;24451492;26469318;27189481;27244685;27883058;29479307;31680844;31999691", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588735.691309.1, SRR26395015.96180.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505387 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Feb 12, 2016 this sequence version replaced XP_005171114.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; The results indicate that LPA2 and LPA3 receptors play opposing roles during red blood cells differentiation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JCV5;F1Q734", "ec_number_list": "", "go_molecular_function": "GO:0070915 lysophosphatidic acid receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0048916 posterior lateral line development;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2BIF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDB4-1", "uniprot_id": "A0A8M2BDB4_DANRE", "mass": 77607.0, "length": 698, "protein_name": "Sodium/hydrogen exchanger", "gene_name": "slc9a7", "organism": "Zebrafish", "refseq_name": "sodium/hydrogen exchanger 7 isoform X1", "refseq_ac": "XP_005166043", "gene_names_uniprotkb": "slc9a7; NHE7; wu:fk03b09; zgc:101088; zgc:113878", "gene_names_refseq": "NHE7; slc9a7; wu:fk03b09; zgc:101088; zgc:113878", "protein_names_uniprotkb": "Sodium/hydrogen exchanger", "protein_names_refseq": "sodium/hydrogen exchanger 7 isoform X1", "tax_id": 7955, "disease": "X-linked intellectual developmental disorder 108 (Disease Ontology:DOID:0111844)", "pathway": " (dre:554532); (R-DRE-425986)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15520368;17069464;17913841;26469318;27189481;28252024;31053140", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane;GO:0006885 regulation of pH", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2BDB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QLA1-1", "uniprot_id": "A0A8M1QLA1_DANRE", "mass": 186376.0, "length": 1658, "protein_name": "Clustered mitochondria protein homolog", "gene_name": "cluhb", "organism": "Zebrafish", "refseq_name": "clustered mitochondria protein homolog isoform X1", "refseq_ac": "XP_001920829", "gene_names_uniprotkb": "cluhb", "gene_names_refseq": "cluhb", "protein_names_uniprotkb": "Clustered mitochondria protein homolog", "protein_names_refseq": "clustered mitochondria protein homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100150676)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001920829.3. COMPLETENESS: full length., [RefSeq]; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0048312 intracellular distribution of mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QLA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCH9-1", "uniprot_id": "A0A8M2BCH9_DANRE", "mass": 89019.0, "length": 802, "protein_name": "ARF GTPase-activating protein GIT2a isoform X1", "gene_name": "git2a", "organism": "Zebrafish", "refseq_name": "ARF GTPase-activating protein GIT2a isoform X1", "refseq_ac": "XP_005165242", "gene_names_uniprotkb": "git2a; git2; si:dkey-234h16.4", "gene_names_refseq": "git2a; git2; si:dkey-234h16.4", "protein_names_uniprotkb": "ARF GTPase-activating protein GIT2a isoform X1", "protein_names_refseq": "ARF GTPase-activating protein GIT2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:793882)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21034731;26469318;27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0007420 brain development;GO:0042074 cell migration involved in gastrulation;GO:0022604 regulation of cell morphogenesis;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BCH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDE6-1", "uniprot_id": "A0A8M2BDE6_DANRE", "mass": 223588.0, "length": 1969, "protein_name": "Sodium channel protein", "gene_name": "scn8ab", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "scn8ab", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); developmental and epileptic encephalopathy 13 (Disease Ontology:DOID:0080445); benign familial infantile seizures 5 (Disease Ontology:DOID:0081118); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0030424 axon;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0031103 axon regeneration;GO:0031101 fin regeneration;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIP7-1", "uniprot_id": "A0A8M2BIP7_DANRE", "mass": 196951.0, "length": 1751, "protein_name": "Intersectin-1", "gene_name": "itsn1", "organism": "Zebrafish", "refseq_name": "intersectin-1 isoform X1", "refseq_ac": "XP_005171028", "gene_names_uniprotkb": "itsn1; SH3; si:dz173a8.1", "gene_names_refseq": "SH3; itsn1; si:dz173a8.1", "protein_names_uniprotkb": "Intersectin-1", "protein_names_refseq": "intersectin-1 isoform X1", "tax_id": 7955, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dre:368504)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15520368;19253391;20659428;26469318;27189481;28252024;35858306;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030027 lamellipodium;GO:0045202 synapse", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0023051 regulation of signaling;GO:0010646 regulation of cell communication;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BIP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFB6-1", "uniprot_id": "A0A8M2BFB6_DANRE", "mass": 84480.0, "length": 732, "protein_name": "Signal transducer and activator of transcription", "gene_name": "stat4", "organism": "Zebrafish", "refseq_name": "signal transducer and activator of transcription 4 isoform X1", "refseq_ac": "XP_005167937", "gene_names_uniprotkb": "stat4; STAT1; STAT; dZ182H3.3; si:by134g18.2; si:by51f19.1; si:dz182h3.3; si:dz199m19.1; si:dz73o4.2", "gene_names_refseq": "STAT1; STAT; dZ182H3.3; si:by134g18.2; si:by51f19.1; si:dz182h3.3; si:dz199m19.1; si:dz73o4.2; stat4", "protein_names_uniprotkb": "Signal transducer and activator of transcription", "protein_names_refseq": "signal transducer and activator of transcription 4 isoform X1", "tax_id": 7955, "disease": "polymyositis (Disease Ontology:DOID:0080745); disabling pansclerotic morphea (Disease Ontology:DOID:0081373); dermatomyositis (Disease Ontology:DOID:10223); primary biliary cholangitis (Disease Ontology:DOID:12236); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); viral hepatitis (Disease Ontology:DOID:1884); rectum adenocarcinoma (Disease Ontology:DOID:1996); autoimmune hepatitis (Disease Ontology:DOID:2048); IgA glomerulonephritis (Disease Ontology:DOID:2986); systemic scleroderma (Disease Ontology:DOID:418); hepatocellular carcinoma (Disease Ontology:DOID:684); Sezary's disease (Disease Ontology:DOID:8541); cholesteatoma (Disease Ontology:DOID:869); genital herpes (Disease Ontology:DOID:8704); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:368519); (R-DRE-8854691); (R-DRE-8984722); (R-DRE-9020591); (R-DRE-9020958)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "18039395;21272652;21914475;22412924;23349717;29453195;30265984;37844410;38152479", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8S045", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0060429 epithelium development;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0019221 cytokine-mediated signaling pathway;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2BFB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFN1-1", "uniprot_id": "A0A8M2BFN1_DANRE", "mass": 77357.0, "length": 697, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "acsl1a", "organism": "Zebrafish", "refseq_name": "long-chain-fatty-acid--CoA ligase 1a isoform X1", "refseq_ac": "XP_005168407", "gene_names_uniprotkb": "acsl1a; acsl1; zgc:110081", "gene_names_refseq": "acsl1a; acsl1; zgc:110081", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase; 6.2.1.3", "protein_names_refseq": "long-chain-fatty-acid--CoA ligase 1a isoform X1", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:555308); (R-DRE-2046105); (R-DRE-2046106); (R-DRE-75876)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J2L6", "ec_number_list": "6.2.1.3;6.2.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0047676 arachidonate-CoA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZZT0-1", "uniprot_id": "Q7ZZT0_DANRE", "mass": 101085.0, "length": 911, "protein_name": "Low density lipoprotein receptor a precursor", "gene_name": "ldlra", "organism": "Zebrafish", "refseq_name": "low density lipoprotein receptor a precursor", "refseq_ac": "NP_001025454", "gene_names_uniprotkb": "ldlra; ldlr", "gene_names_refseq": "ldlra; ldlr", "protein_names_uniprotkb": "Low density lipoprotein receptor a precursor", "protein_names_refseq": "low density lipoprotein receptor a precursor", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); familial hyperlipidemia (Disease Ontology:DOID:1168); migraine without aura (Disease Ontology:DOID:12783); familial hypercholesterolemia (Disease Ontology:DOID:13810); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); xanthomatosis (Disease Ontology:DOID:3345); systemic lupus erythematosus (Disease Ontology:DOID:9074); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dre:387529); (R-DRE-8964038)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12748389;21722753;22152339;22205629;23416188;38001454;38234580;38333845;38621217;38660750", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505375 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY218841.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N7V5;F6P6T4", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005041 low-density lipoprotein particle receptor activity;GO:0071813 lipoprotein particle binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0034362 low-density lipoprotein particle;GO:0005576 extracellular region;GO:0005769 early endosome", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0071222 cellular response to lipopolysaccharide;GO:0042632 cholesterol homeostasis;GO:0090118 receptor-mediated endocytosis involved in cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZZT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCH5-1", "uniprot_id": "A0A8M2BCH5_DANRE", "mass": 127858.0, "length": 1141, "protein_name": "Guanylate cyclase", "gene_name": "gucy2d", "organism": "Zebrafish", "refseq_name": "retinal guanylyl cyclase 1 isoform X1", "refseq_ac": "XP_005165318", "gene_names_uniprotkb": "gucy2d; GUCY2d1; RETGC-3; gc3", "gene_names_refseq": "GUCY2d1; RETGC-3; gc3; gucy2d", "protein_names_uniprotkb": "Guanylate cyclase; 4.6.1.2", "protein_names_refseq": "retinal guanylyl cyclase 1 isoform X1", "tax_id": 7955, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); Leber congenital amaurosis 1 (Disease Ontology:DOID:0110078); cone-rod dystrophy 6 (Disease Ontology:DOID:0111011); retinitis pigmentosa (Disease Ontology:DOID:10584); choroidal sclerosis (Disease Ontology:DOID:980)", "pathway": " (R-DRE-2514859)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12234666;12533607;16311625;19168097;19500364;27189481;28378769;29422031;32533080;33795334", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JH69;A0AC58JH72", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BCH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZSY6-1", "uniprot_id": "MT2_DANRE", "mass": 5976.0, "length": 60, "protein_name": "Metallothionein-2", "gene_name": "mt2", "organism": "Zebrafish", "refseq_name": "metallothionein-2", "refseq_ac": "NP_001124525", "gene_names_uniprotkb": "mt2", "gene_names_refseq": "MT-2; mt1; mt2; mt; wu:fc77e11; wu:fj10c11", "protein_names_uniprotkb": "Metallothionein-2; MT-2", "protein_names_refseq": "metallothionein A; metallothionein IIA; metallothionein IIB; metallothionein-1; metallothionein-2", "tax_id": 7955, "disease": "carotid stenosis (Disease Ontology:DOID:13001); psychotic disorder (Disease Ontology:DOID:2468); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (dre:100174951)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12408584;15276328", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01036852.1, EH508165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jun 3, 2009 this sequence version replaced NP_001124525.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Metallothioneins have a high content of cysteine residues that bind various heavy metals., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0001525 angiogenesis;GO:0010043 response to zinc ion;GO:0010575 positive regulation of vascular endothelial growth factor production;GO:0046686 response to cadmium ion;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZSY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PGW0-1", "uniprot_id": "A0A8M9PGW0_DANRE", "mass": 65578.0, "length": 584, "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X1", "gene_name": "eps8l1a", "organism": "Zebrafish", "refseq_name": "epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X1", "refseq_ac": "XP_021326188", "gene_names_uniprotkb": "eps8l1a; eps8l1; zgc:113583", "gene_names_refseq": "eps8l1a; eps8l1; zgc:113583", "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X1", "protein_names_refseq": "epidermal growth factor receptor kinase substrate 8-like protein 1a isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_021326188.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PGW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QHJ9-1", "uniprot_id": "I17RD_DANRE", "mass": 83391.0, "length": 745, "protein_name": "Interleukin-17 receptor D", "gene_name": "il17rd", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "il17rd; cb208; id:ibd2875; id:ibd5059; sef; zgc:136328", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-17 receptor D; IL-17 receptor D; IL-17RD; Sef; Similar expression to FGF genes protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 18 with or without anosmia (Disease Ontology:DOID:0090076)", "pathway": " (dre:171474); (R-DRE-5674135)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11731487;11802164;11802165;14660439;15151985;27640326;28085667;28096348;31910335;32934222", "class_list": "", "function": "Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBV6;Q8QHJ6", "ec_number_list": "", "go_molecular_function": "GO:0030368 interleukin-17 receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0009953 dorsal/ventral pattern formation;GO:0043409 negative regulation of MAPK cascade;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8QHJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW98-1", "uniprot_id": "AP2MB_DANRE", "mass": 49743.0, "length": 436, "protein_name": "AP-2 complex subunit mu-B", "gene_name": "ap2m1b", "organism": "Zebrafish", "refseq_name": "AP-2 complex subunit mu-B", "refseq_ac": "NP_957320", "gene_names_uniprotkb": "ap2m1b; ap2m1; zgc:56643", "gene_names_refseq": "ap2m1b; ap2m1; zgc:56643", "protein_names_uniprotkb": "AP-2 complex subunit mu-B; AP-2 mu-B chain; Clathrin assembly protein complex 2 mu-B medium chain; Clathrin coat assembly protein AP50-B; Clathrin coat-associated protein AP50-B; Mu2-adaptin-B; Plasma membrane adaptor AP-2 50 kDa protein B", "protein_names_refseq": "AP-2 complex subunit mu-1-B; AP-2 complex subunit mu-B; AP-2 mu-2 chain B; AP-2 mu-B chain; adaptor-related protein complex 2, mu 1 subunit, b; clathrin assembly protein complex 2 medium chain B; clathrin assembly protein complex 2 mu-B medium chain; clathrin coat assembly protein AP50-B; clathrin coat-associated protein AP50-B; mu2-adaptin-B; plasma membrane adaptor AP-2 50 kDa protein B", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 60 with seizures (Disease Ontology:DOID:0061050); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:394001); (R-DRE-177504); (R-DRE-196025); (R-DRE-416993); (R-DRE-5099900); (R-DRE-8856825); (R-DRE-8964038)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004289.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jul 21, 2025 this sequence version replaced NP_957320.1., [RefSeq]; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle;GO:0030121 AP-1 adaptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016055 Wnt signaling pathway;GO:0072583 clathrin-dependent endocytosis;GO:0006896 Golgi to vacuole transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZW98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW38-1", "uniprot_id": "SPS1_DANRE", "mass": 42923.0, "length": 392, "protein_name": "Selenide, water dikinase 1", "gene_name": "sephs1", "organism": "Zebrafish", "refseq_name": "selenide, water dikinase 1", "refseq_ac": "NP_955995", "gene_names_uniprotkb": "sephs1; si:ch211-220f12.5; wu:fc49b09; zgc:55304", "gene_names_refseq": "sephs1; wu:fc49b09; zgc:55304", "protein_names_uniprotkb": "Selenide, water dikinase 1; 2.7.9.3; Selenium donor protein 1; Selenophosphate synthase 1", "protein_names_refseq": "selenide, water dikinase 1; selenium donor protein 1; selenophosphate synthase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:324947)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18307296;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045302.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505388, SAMEA4476730 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EE312480.1, CT658572.2, BC045302.1, EB797523.1 and CN510578.1. On Sep 15, 2007 this sequence version replaced NP_955995.1., [RefSeq]; Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, and stabilizes them onto their cognate DNA motif. Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability. Plays an essential role in redox homeostasis. May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LXT8", "ec_number_list": "2.7.9.3", "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005694 chromosome", "go_biological_process": "GO:0016260 selenocysteine biosynthetic process;GO:0006351 DNA-templated transcription;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZW38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UW00-1", "uniprot_id": "HN1BB_DANRE", "mass": 58320.0, "length": 532, "protein_name": "Hepatocyte nuclear factor 1-beta-B", "gene_name": "hnf1bb", "organism": "Zebrafish", "refseq_name": "hepatocyte nuclear factor 1-beta-B", "refseq_ac": "NP_919353", "gene_names_uniprotkb": "hnf1bb; HNF1g; hnf1bl; hnf1gamma; hnf1g; wu:fc23f06", "gene_names_refseq": "HNF1g; hnf1bb; hnf1bl; hnf1gamma; wu:fc23f06", "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-beta-B; HNF-1-beta-B; HNF-1B-B; HNF1g; Hepatocyte nuclear factor 1-beta-like; Hepatocyte nuclear factor 1-gamma", "protein_names_refseq": "hepatocyte nuclear factor 1-beta-B; liver-enriched atypical homeobox-containing transcription factor; transcription factor 2 like protein", "tax_id": 7955, "disease": "esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); renal cysts and diabetes syndrome (Disease Ontology:DOID:0111101); pancreas disease (Disease Ontology:DOID:26); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:324283)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18945197", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588735.2551234.1, SRR32588715.1670015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On Jul 6, 2005 this sequence version replaced XP_697844.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments and orthologous alignments., [RefSeq]; Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of hnf1ba but is not required for induction of rhombomere r5/r6 gene expression in the hindbrain., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0031016 pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8UW00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVC2-1", "uniprot_id": "CLUA1_DANRE", "mass": 49127.0, "length": 427, "protein_name": "Clusterin-associated protein 1 homolog", "gene_name": "cluap1", "organism": "Zebrafish", "refseq_name": "clusterin-associated protein 1 homolog", "refseq_ac": "NP_998173", "gene_names_uniprotkb": "cluap1; fj16b11; unm_au5; wu:fj16b11; zgc:56115", "gene_names_refseq": "cluap1; fj16b11; ift38; unm_au5; wu:fj16b11; zgc:56115", "protein_names_uniprotkb": "Clusterin-associated protein 1 homolog; Qilin", "protein_names_refseq": "clusterin associated protein 1; clusterin-associated protein 1 homolog; qilin; qil", "tax_id": 7955, "disease": "", "pathway": " (dre:406281)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19464178;22102889;26820066", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045921.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045921.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Consistent with the knowledge that CLUAP1 plays an important role in cilia function and that cilia are critical to photoreceptor function, our results indicate that hypomorphic mutations in CLUAP1 can result in dysfunctional photoreceptors without systemic abnormalities. This is the first report linking mutations in CLUAP1 to human disease and establishes CLUAP1 as a candidate Leber congenital amaurosis gene, [RefSeq, PubMed]; Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V941;Q6NWG3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0001822 kidney development;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZVC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU90-1", "uniprot_id": "CHD1L_DANRE", "mass": 116249.0, "length": 1026, "protein_name": "ATP-dependent chromatin remodeler CHD1l", "gene_name": "chd1l", "organism": "Zebrafish", "refseq_name": "ATP-dependent chromatin remodeler CHD1l", "refseq_ac": "NP_956607", "gene_names_uniprotkb": "chd1l; zgc:56084", "gene_names_refseq": "chd1l; zgc:56084", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD1l; 3.6.4.-; Chromo domain-containing protein 1-like", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD1l; chromo domain-containing protein 1-like", "tax_id": 7955, "disease": "", "pathway": " (dre:393283); (R-DRE-5696395); (R-DRE-5696400)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050498.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA4476744, SAMEA4476749 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050498.1., [RefSeq]; ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;2.7.7.7;5.6.2.-;2.7.7.49;5.6.2.5;3.6.5.-;2.4.2.-;2.4.2.30;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0016887 ATP hydrolysis activity;GO:0031491 nucleosome binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006974 DNA damage response;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZU90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZYX1-1", "uniprot_id": "AKTIP_DANRE", "mass": 33201.0, "length": 293, "protein_name": "AKT-interacting protein", "gene_name": "aktip", "organism": "Zebrafish", "refseq_name": "AKT-interacting protein", "refseq_ac": "NP_001307253", "gene_names_uniprotkb": "aktip; cb798; fts; zgc:77699", "gene_names_refseq": "aktip; cb798; fts; zgc:77699", "protein_names_uniprotkb": "AKT-interacting protein; Fused toes protein homolog", "protein_names_refseq": "AKT-interacting protein; fused toes homolog; fused toes protein homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:378716)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH442845.1, SRR32588733.2919503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1. On Feb 20, 2016 this sequence version replaced XP_005169025.1. Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3I9", "ec_number_list": "", "go_molecular_function": "GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0070695 FHF complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0006915 apoptotic process;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZYX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JJ26-1", "uniprot_id": "SEBOX_DANRE", "mass": 33386.0, "length": 293, "protein_name": "Homeobox protein SEBOX", "gene_name": "sebox", "organism": "Zebrafish", "refseq_name": "homeobox protein SEBOX", "refseq_ac": "NP_001306981", "gene_names_uniprotkb": "sebox; og9x; si:ch211-110p13.7", "gene_names_refseq": "og9x; sebox", "protein_names_uniprotkb": "Homeobox protein SEBOX; Homeobox OG-9; Homeobox transcription factor mezzo; Skin-, embryo-, brain- and oocyte-specific homeobox", "protein_names_refseq": "OG9 homeobox; homeobox OG-9; homeobox protein SEBOX; homeobox transcription factor mezzo; skin-, embryo-, brain- and oocyte-specific homeobox", "tax_id": 7955, "disease": "", "pathway": " (dre:282666)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12397099;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395014.823699.1, SRR26395014.388040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Probable transcription factor involved in the control of specification of mesoderm and endoderm. Acts in parallel with bonnie and clyde, faust and casanova in the Nodal signaling pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BIQ1", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0003007 heart morphogenesis;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JJ26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QHL5-1", "uniprot_id": "PHC2_DANRE", "mass": 88680.0, "length": 827, "protein_name": "Polyhomeotic-like protein 2", "gene_name": "phc2a; phc2", "organism": "Zebrafish", "refseq_name": "polyhomeotic-like protein 2 isoform b", "refseq_ac": "NP_001129960", "gene_names_uniprotkb": "phc2a; phc2; cb218; edr2; ph2[a]; ph2[b]; ph2alpha; ph2beta; ph2; phc2", "gene_names_refseq": "cb218; edr2; ph2[a]; ph2[b]; ph2alpha; ph2beta; ph2; phc2a; phc2", "protein_names_uniprotkb": "Polyhomeotic-like protein 2", "protein_names_refseq": "early development regulator 2 (homolog of polyhomeotic 2); polyhomeotic-like protein 2 isoform b; polyhomeotic-like protein 2", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:171465); (R-DRE-2559580); (R-DRE-3108214); (R-DRE-3899300); (R-DRE-4570464); (R-DRE-8939243); (R-DRE-8953750)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "11731487;11846397;15520368;15707958;17703193;18426981;21195142;21555364;26794130;27189481;29985950", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044345.1, AY398396.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Collectively, the data argue that ph2alpha is required for epiboly and tailbud formation, acting downstream of the FGF signaling pathway, [RefSeq, PubMed]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DGB9;Q6TGW0;Q7ZYX8;Q8QHL4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8QHL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JI14-1", "uniprot_id": "RHCL2_DANRE", "mass": 53753.0, "length": 488, "protein_name": "Ammonium transporter Rh type C-like 2", "gene_name": "rhcgb; rhcgl2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rhcgb; rhcgl2; rhcg1; rhcgl2; rhcg; zgc:77520", "gene_names_refseq": "", "protein_names_uniprotkb": "Ammonium transporter Rh type C-like 2; Rh family type C glycoprotein-like 2; Rh type C glycoprotein-like 2; Rhesus blood group family type C glycoprotein-like 2; drRhcg1", "protein_names_refseq": "", "tax_id": 7955, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); kidney failure (Disease Ontology:DOID:1074); renal tubular acidosis (Disease Ontology:DOID:14219); hypokalemia (Disease Ontology:DOID:4500)", "pathway": " (dre:792274)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16227429;17686885;18815227;19279128;19915127;32437959;32755465;33059022;33113650;34318705", "class_list": "", "function": "Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity)., [UniProtKB]; Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5LHA7;Q6NYR3", "ec_number_list": "", "go_molecular_function": "GO:0008519 ammonium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0072488 ammonium transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8JI14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU92-1", "uniprot_id": "PARN_DANRE", "mass": 75261.0, "length": 660, "protein_name": "Poly(A)-specific ribonuclease PARN", "gene_name": "parn", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "parn; zgc:56067", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly(A)-specific ribonuclease PARN; 3.1.13.4; Polyadenylate-specific ribonuclease", "protein_names_refseq": "", "tax_id": 7955, "disease": "autosomal recessive dyskeratosis congenita 6 (Disease Ontology:DOID:0070024)", "pathway": " (dre:791461); (R-DRE-450604)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15520368;17895525;18307296;26342108;26566657;27235108;30061596;37340076", "class_list": "", "function": "3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6TGW3", "ec_number_list": "3.1.13.4", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0043169 cation binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030097 hemopoiesis;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:1990431 priRNA 3'-end processing;GO:1990432 siRNA 3'-end processing;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7ZU92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B840-1", "uniprot_id": "A0A8M2B840_DANRE", "mass": 50291.0, "length": 446, "protein_name": "NAD kinase 2, mitochondrial", "gene_name": "nadk2", "organism": "Zebrafish", "refseq_name": "NAD kinase 2, mitochondrial isoform X1", "refseq_ac": "XP_005161222", "gene_names_uniprotkb": "nadk2; nadkd1; zgc:92417", "gene_names_refseq": "nadk2; nadkd1; zgc:92417", "protein_names_uniprotkb": "NAD kinase 2, mitochondrial; 2.7.1.23; NAD kinase domain-containing protein 1, mitochondrial", "protein_names_refseq": "NAD kinase 2, mitochondrial isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:445071)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21873635", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.23", "go_molecular_function": "GO:0003951 NAD+ kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0019674 NAD+ metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2B840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCX5-1", "uniprot_id": "A0A8M2BCX5_DANRE", "mass": 31730.0, "length": 286, "protein_name": "Palmitoyl-protein thioesterase ABHD10, mitochondrial", "gene_name": "abhd10a", "organism": "Zebrafish", "refseq_name": "abhydrolase domain containing 10, depalmitoylase a isoform X1", "refseq_ac": "XP_005165696", "gene_names_uniprotkb": "abhd10a; abhd10; fb10b08; si:ch211-271b14.3; wu:fb10b08", "gene_names_refseq": "abhd10a; abhd10; fb10b08; si:ch211-271b14.3; wu:fb10b08", "protein_names_uniprotkb": "Palmitoyl-protein thioesterase ABHD10, mitochondrial; 3.1.1.93; 3.1.2.22; Acyl-protein thioesterase ABHD10; Alpha/beta hydrolase domain-containing protein 10; Mycophenolic acid acyl-glucuronide esterase, mitochondrial", "protein_names_refseq": "abhydrolase domain containing 10, depalmitoylase a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568517)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.22;3.4.19.12;3.1.1.93;3.1.2.2", "go_molecular_function": "GO:0102390 mycophenolic acid acyl-glucuronide esterase activity;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BCX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7R9-1", "uniprot_id": "A0A8M2B7R9_DANRE", "mass": 37074.0, "length": 324, "protein_name": "Uncharacterized protein LOC378872 isoform 2; Uncharacterized protein isoform X2", "gene_name": "fam49a", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC378872 isoform 2", "refseq_ac": "NP_001311422", "gene_names_uniprotkb": "fam49a; fam49ab; sb:cb866; si:ch211-223o11.1; si:ch211-89p3.1; zgc:55309; znf395", "gene_names_refseq": "fam49ab; fam49a; sb:cb866; si:ch211-223o11.1; si:ch211-89p3.1; zgc:55309; znf395", "protein_names_uniprotkb": "Uncharacterized protein LOC378872 isoform 2; Uncharacterized protein isoform X2", "protein_names_refseq": "uncharacterized protein LOC378872 isoform 2; zinc finger protein 395", "tax_id": 7955, "disease": "", "pathway": " (dre:378872)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16603149;23698347;26469318;27189481;27827822;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR4321680.605612.1, SRR32588724.2640406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On Jul 8, 2016 this sequence version replaced XP_005160704.1., [RefSeq]; Ndrg1b and fam49ab are 2 new modulators of PTEN signaling that control lymphoid differentiation in the zebrafish thymus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I245;A0AC58I250;A0AC58I252;A0AC58I254;Q5TZ57", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0045580 regulation of T cell differentiation;GO:0048538 thymus development;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B7R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVG6-1", "uniprot_id": "SIAH1_DANRE", "mass": 31080.0, "length": 282, "protein_name": "E3 ubiquitin-protein ligase Siah1", "gene_name": "siah1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase Siah1", "refseq_ac": "NP_955815", "gene_names_uniprotkb": "siah1; Siah1a; id:ibd2635; zgc:56026", "gene_names_refseq": "Siah1a; id:ibd2635; siah1; zgc:56026", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Siah1; 2.3.2.27; RING-type E3 ubiquitin transferase SIAH1; Seven in absentia homolog 1; Siah-1", "protein_names_refseq": "E3 ubiquitin-protein ligase Siah1; RING-type E3 ubiquitin transferase SIAH1; seven in absentia 1A; seven in absentia homolog 1; siah-1", "tax_id": 7955, "disease": "", "pathway": " (dre:80955); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045870.1, CO804390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045870.1., [RefSeq]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ18-1", "uniprot_id": "A0A8M2BJ18_DANRE", "mass": 137602.0, "length": 1284, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "tnksb", "organism": "Zebrafish", "refseq_name": "tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b isoform X1", "refseq_ac": "XP_005171800", "gene_names_uniprotkb": "tnksb; fe02c12; si:ch211-155m12.3; wu:fe02c12", "gene_names_refseq": "fe02c12; si:ch211-155m12.3; tnksb; wu:fe02c12", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0005737 cytoplasm", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0016055 Wnt signaling pathway;GO:0070198 protein localization to chromosome, telomeric region;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1904355 positive regulation of telomere capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKP3-1", "uniprot_id": "A0A8M2BKP3_DANRE", "mass": 90503.0, "length": 808, "protein_name": "Stromal interaction molecule 1a isoform X1", "gene_name": "stim1a", "organism": "Zebrafish", "refseq_name": "stromal interaction molecule 1a isoform X1", "refseq_ac": "XP_005173449", "gene_names_uniprotkb": "stim1a; si:dkey-24p1.5", "gene_names_refseq": "si:dkey-24p1.5; stim1a", "protein_names_uniprotkb": "Stromal interaction molecule 1a isoform X1", "protein_names_refseq": "stromal interaction molecule 1a isoform X1", "tax_id": 7955, "disease": "Stormorken syndrome (Disease Ontology:DOID:0060354); tubular aggregate myopathy 1 (Disease Ontology:DOID:0080089); immunodeficiency 10 (Disease Ontology:DOID:0111970); stomach cancer (Disease Ontology:DOID:10534); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:556360)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;26469318;27189481;27702423;28252024;30889933;31023836;32455839;32867296;34545403", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051049 regulation of transport;GO:0006874 intracellular calcium ion homeostasis;GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BKP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6C7-1", "uniprot_id": "NDF6B_DANRE", "mass": 36196.0, "length": 317, "protein_name": "Neurogenic differentiation factor 6-B", "gene_name": "neurod6b", "organism": "Zebrafish", "refseq_name": "neurogenic differentiation factor 6-B isoform 2", "refseq_ac": "NP_001296773", "gene_names_uniprotkb": "neurod6b; Zath2b; atoh2b; ndr1b; zNdr1b; zgc:92543", "gene_names_refseq": "Zath2b; atoh2b; ndr1b; neurod6b; zNdr1b; zgc:92543", "protein_names_uniprotkb": "Neurogenic differentiation factor 6-B; NeuroD6-B; Protein atonal homolog 2-B", "protein_names_refseq": "atonal homolog 2b; neuroD6-B; neurogenic differentiation 6b; neurogenic differentiation factor 6-B isoform 2; neurogenic differentiation factor 6-B; protein atonal homolog 2-B", "tax_id": 7955, "disease": "", "pathway": " (dre:114415)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10235116;12044886;16132106;19449054;19650145;21544580;28329862;29192226;29695303;29945667;35286299", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DV585951.1, SRR32588732.28047841.1 [ECO:0000332] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Both variants 2 and 3 encode the same isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Differentiation factor required for neurogenesis (By similarity). Does not act as an upstream activator of isl1., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DHB0", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061564 axon development;GO:0007423 sensory organ development;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W6C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKD0-1", "uniprot_id": "A0A8M2BKD0_DANRE", "mass": 54088.0, "length": 472, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-2a isoform X1", "gene_name": "gabrb2a", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-2a isoform X1", "refseq_ac": "XP_005173160", "gene_names_uniprotkb": "gabrb2a; fj59e04; gabaabeta2; gabrb2; si:ch211-215g18.1; wu:fj59e04; zgc:136311", "gene_names_refseq": "fj59e04; gabaabeta2; gabrb2a; gabrb2; si:ch211-215g18.1; wu:fj59e04; zgc:136311", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-2a isoform X1", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit beta-2a isoform X1", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); developmental and epileptic encephalopathy 92 (Disease Ontology:DOID:0080471); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (dre:336252)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "22207143;25733401;26469318;26982811;27189481;33979209;34957497;36768529;37093397;38908344", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0031410 cytoplasmic vesicle;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0070208 protein heterotrimerization;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BKD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AK78-1", "uniprot_id": "A0A8M3AK78_DANRE", "mass": 63312.0, "length": 581, "protein_name": "Mothers against decapentaplegic homolog", "gene_name": "smad10a; smad10b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC560317 isoform 1", "refseq_ac": "NP_001352568", "gene_names_uniprotkb": "smad10a; smad10b; sb:eu479; si:dkey-222b8.1; smad10b", "gene_names_refseq": "sb:eu479; si:dkey-222b8.1; smad10a", "protein_names_uniprotkb": "Mothers against decapentaplegic homolog; MAD homolog; Mothers against DPP homolog; SMAD family member", "protein_names_refseq": "uncharacterized protein LOC560317 isoform 1", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (dre:100151181); (dre:560317)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25556858;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01037107.1, SRR32588723.3564334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476732, SAMEA4476736 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Sep 12, 2018 this sequence version replaced XP_005170105.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0071144 heteromeric SMAD protein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M3AK78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B880-1", "uniprot_id": "A0A8M2B880_DANRE", "mass": 25321.0, "length": 224, "protein_name": "Proheparin-binding EGF-like growth factor", "gene_name": "hbegfb", "organism": "Zebrafish", "refseq_name": "heparin-binding EGF-like growth factor b isoform X1", "refseq_ac": "XP_005161354", "gene_names_uniprotkb": "hbegfb; hbegf; zgc:165443", "gene_names_refseq": "hbegfb; hbegf; zgc:165443", "protein_names_uniprotkb": "Proheparin-binding EGF-like growth factor", "protein_names_refseq": "heparin-binding EGF-like growth factor b isoform X1", "tax_id": 7955, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); acute kidney failure (Disease Ontology:DOID:3021); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (dre:407664)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19000772;19064678;20105326;26089336;26469318;31398318;32850848;34016526;37567873;38088047", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005161354.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0060047 heart contraction;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PT92-1", "uniprot_id": "CATA_DANRE", "mass": 59654.0, "length": 526, "protein_name": "Catalase", "gene_name": "cat", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "cat; fb68a12; wu:fb68a12", "gene_names_refseq": "", "protein_names_uniprotkb": "Catalase; 1.11.1.6", "protein_names_refseq": "", "tax_id": 7955, "disease": "pterygium (Disease Ontology:DOID:0002116); chronic venous insufficiency (Disease Ontology:DOID:0050853); colitis (Disease Ontology:DOID:0060180); alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); Graves ophthalmopathy (Disease Ontology:DOID:0081120); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); retinitis pigmentosa (Disease Ontology:DOID:10584); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); essential hypertension (Disease Ontology:DOID:10825); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); optic neuritis (Disease Ontology:DOID:1210); tympanosclerosis (Disease Ontology:DOID:1214); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); Behcet's disease (Disease Ontology:DOID:13241); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); keratosis (Disease Ontology:DOID:161); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); acatalasia (Disease Ontology:DOID:2582); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast adenocarcinoma (Disease Ontology:DOID:3458); toxic encephalopathy (Disease Ontology:DOID:3602); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ureteral obstruction (Disease Ontology:DOID:5199); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); congestive heart failure (Disease Ontology:DOID:6000); fibromyalgia (Disease Ontology:DOID:631); acne (Disease Ontology:DOID:6543); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); scabies (Disease Ontology:DOID:8295); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); seborrheic dermatitis (Disease Ontology:DOID:8741); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); pemphigus (Disease Ontology:DOID:9182); lichen planus (Disease Ontology:DOID:9201); phenylketonuria (Disease Ontology:DOID:9281); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); stomatitis (Disease Ontology:DOID:9637); senile cataract (Disease Ontology:DOID:9669); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (dre:30068); (R-DRE-3299685); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10888504;11281262;16412219;17855494;17898172;38283058;38357503;38397774;38717324;39029645;40044042", "class_list": "", "function": "Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 77, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9I8V5", "ec_number_list": "4.2.99.18;5.6.2.4;2.7.1.11;3.6.4.13;2.7.1.40;1.1.1.205;5.4.2.11;5.4.2.4;2.7.1.35;1.13.11.34;3.2.1.31;3.6.5.-;2.3.2.27;3.6.4.6;4.1.2.13;2.7.11.24;1.11.1.6", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004096 catalase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0042542 response to hydrogen peroxide;GO:0046688 response to copper ion;GO:0042744 hydrogen peroxide catabolic process;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9PT92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWE6-1", "uniprot_id": "DTB1A_DANRE", "mass": 40857.0, "length": 362, "protein_name": "Dysbindin-A", "gene_name": "dtnbp1a", "organism": "Zebrafish", "refseq_name": "dysbindin-A", "refseq_ac": "NP_957428", "gene_names_uniprotkb": "dtnbp1a; bloc1s8; dtnbp1; zgc:56462", "gene_names_refseq": "dtnbp1a; dtnbp1; zgc:56462", "protein_names_uniprotkb": "Dysbindin-A; BLOC-1 subunit 8-A; Biogenesis of lysosome-related organelles complex 1 subunit 8-A; Dystrobrevin-binding protein 1-A", "protein_names_refseq": "BLOC-1 subunit 8-A; biogenesis of lysosome-related organelles complex 1 subunit 8-A; dysbindin-A; dystrobrevin binding protein 1; dystrobrevin-binding protein 1-A; hps7", "tax_id": 7955, "disease": "Hermansky-Pudlak syndrome 7 (Disease Ontology:DOID:0060545); platelet storage pool deficiency (Disease Ontology:DOID:2223); temporal lobe epilepsy (Disease Ontology:DOID:3328); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (dre:394109)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049451.1, BC152672.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505377 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049451.1., [RefSeq]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0010008 endosome membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0060155 platelet dense granule organization;GO:0009966 regulation of signal transduction;GO:0008089 anterograde axonal transport;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZWE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B789-1", "uniprot_id": "A0A8M2B789_DANRE", "mass": 54288.0, "length": 501, "protein_name": "Zinc transporter 1a isoform X1", "gene_name": "slc30a1a", "organism": "Zebrafish", "refseq_name": "zinc transporter 1a isoform X1", "refseq_ac": "XP_005160488", "gene_names_uniprotkb": "slc30a1a; slc30a1; zgc:77589", "gene_names_refseq": "slc30a1a; slc30a1; zgc:77589", "protein_names_uniprotkb": "Zinc transporter 1a isoform X1", "protein_names_refseq": "zinc transporter 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0010312 detoxification of zinc ion;GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0097325 melanocyte proliferation;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B789-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7H0-1", "uniprot_id": "A0A8M2B7H0_DANRE", "mass": 413655.0, "length": 3739, "protein_name": "Apolipoprotein Bb, tandem duplicate 1 isoform X1", "gene_name": "apobb.1", "organism": "Zebrafish", "refseq_name": "apolipoprotein Bb, tandem duplicate 1 isoform X1", "refseq_ac": "XP_005160686", "gene_names_uniprotkb": "apobb.1; apobb; apobl; cb235; hm:zeh1207; sb:cb235; si:ch211-219i10.1; wu:fb39c11; wu:fc51e12; zeh1207", "gene_names_refseq": "apobb.1; apobb; apobl; cb235; hm:zeh1207; sb:cb235; si:ch211-219i10.1; wu:fb39c11; wu:fc51e12; zeh1207", "protein_names_uniprotkb": "Apolipoprotein Bb, tandem duplicate 1 isoform X1", "protein_names_refseq": "apolipoprotein Bb, tandem duplicate 1 isoform X1", "tax_id": 7955, "disease": "familial hypobetalipoproteinemia 2 (Disease Ontology:DOID:0111061); familial hypobetalipoproteinemia 1 (Disease Ontology:DOID:0111062); sickle cell anemia (Disease Ontology:DOID:10923); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); beta thalassemia (Disease Ontology:DOID:12241); cardiovascular system disease (Disease Ontology:DOID:1287); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390); aortic valve stenosis (Disease Ontology:DOID:1712); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); gallbladder cancer (Disease Ontology:DOID:3121); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); bile duct cancer (Disease Ontology:DOID:4606); biliary tract cancer (Disease Ontology:DOID:4607); common bile duct neoplasm (Disease Ontology:DOID:4608); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:321166)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11116087;18343608;18618001;19200601;19308258;35066078;35110541;37332366;38699158;39528516;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 26, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0120020 cholesterol transfer activity;GO:0005319 lipid transporter activity", "go_cellular_component": "GO:0034361 very-low-density lipoprotein particle;GO:0034362 low-density lipoprotein particle;GO:0034359 mature chylomicron;GO:0005576 extracellular region", "go_biological_process": "GO:0042953 lipoprotein transport;GO:0071466 cellular response to xenobiotic stimulus;GO:0042632 cholesterol homeostasis;GO:0030301 cholesterol transport;GO:0006642 triglyceride mobilization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M2B7H0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B846-1", "uniprot_id": "A0A8M2B846_DANRE", "mass": 101937.0, "length": 905, "protein_name": "Complement component C6 precursor", "gene_name": "c6.1; c6.2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "c6.1; c6.2; c6.1; c6; si:ch211-22d5.4; zgc:64073", "gene_names_refseq": "", "protein_names_uniprotkb": "Complement component C6 precursor", "protein_names_refseq": "", "tax_id": 7955, "disease": "complement component 6 deficiency (Disease Ontology:DOID:0060299); alcohol-associated liver disease (Disease Ontology:DOID:0070658); glomerulonephritis (Disease Ontology:DOID:2921); proteinuria (Disease Ontology:DOID:576); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dre:393611); (dre:798694)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "18657447;19200601;22355335;23458150;26469318;34185526;35159152;35264012;36640352;36736605;40044042", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M2B846-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8V2-1", "uniprot_id": "A0A8M2B8V2_DANRE", "mass": 197803.0, "length": 1794, "protein_name": "Laminin subunit beta-2 isoform X1", "gene_name": "lamb2", "organism": "Zebrafish", "refseq_name": "laminin subunit beta-2 isoform X1", "refseq_ac": "XP_005162102", "gene_names_uniprotkb": "lamb2; si:dkey-32e6.2", "gene_names_refseq": "lamb2; si:dkey-32e6.2", "protein_names_uniprotkb": "Laminin subunit beta-2 isoform X1", "protein_names_refseq": "laminin subunit beta-2 isoform X1", "tax_id": 7955, "disease": "Pierson syndrome (Disease Ontology:DOID:0060852); nephrotic syndrome type 5 (Disease Ontology:DOID:0080380); primary open angle glaucoma (Disease Ontology:DOID:1070); nephrosis (Disease Ontology:DOID:2527); proteinuria (Disease Ontology:DOID:576)", "pathway": " (dre:337767)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19736328;21246659;22713473;23118857;24941943;31034836;34568948;35175196;36142434;37884489", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162102.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0150043 structural constituent of synapse-associated extracellular matrix", "go_cellular_component": "GO:0043256 laminin complex;GO:0005604 basement membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0021782 glial cell development;GO:0016477 cell migration;GO:0060041 retina development in camera-type eye;GO:0009887 animal organ morphogenesis;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B8V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8Y1-1", "uniprot_id": "A0A8M2B8Y1_DANRE", "mass": 60283.0, "length": 537, "protein_name": "Uridine-cytidine kinase", "gene_name": "uckl1b", "organism": "Zebrafish", "refseq_name": "uridine-cytidine kinase-like 1 isoform X1", "refseq_ac": "XP_005162063", "gene_names_uniprotkb": "uckl1b", "gene_names_refseq": "uckl1b", "protein_names_uniprotkb": "Uridine-cytidine kinase; 2.7.1.48", "protein_names_refseq": "uridine-cytidine kinase-like 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:558466)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May contribute to UTP accumulation needed for blast transformation and proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage;GO:0008655 pyrimidine-containing compound salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZTW4-1", "uniprot_id": "SGK1_DANRE", "mass": 48983.0, "length": 433, "protein_name": "Serine/threonine-protein kinase Sgk1", "gene_name": "sgk1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase Sgk1", "refseq_ac": "NP_954682", "gene_names_uniprotkb": "sgk1; cb1083; sgk; wu:fc20a09", "gene_names_refseq": "cb1083; sgk1; sgk; wu:fc20a09", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk1; 2.7.11.1; Serum/glucocorticoid-regulated kinase 1", "protein_names_refseq": "serine/threonine-protein kinase Sgk1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); granulosa cell tumor (Disease Ontology:DOID:2999); serous cystadenocarcinoma (Disease Ontology:DOID:3114); mucinous cystadenocarcinoma (Disease Ontology:DOID:3603)", "pathway": " (dre:324140); (R-DRE-1257604); (R-DRE-6804757); (R-DRE-9031628)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "37276417", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC052134.1, EF512629.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC052134.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31;2.3.2.27", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0106310 protein serine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZTW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B975-1", "uniprot_id": "A0A8M2B975_DANRE", "mass": 118250.0, "length": 1058, "protein_name": "E1 ubiquitin-activating enzyme", "gene_name": "uba1", "organism": "Zebrafish", "refseq_name": "ubiquitin-like modifier-activating enzyme 1 isoform X1", "refseq_ac": "XP_005162108", "gene_names_uniprotkb": "uba1; fb30f01; ube1; wu:fa01e08; wu:fb30f01; wu:fi21c11; wu:fj14g11; zgc:66143", "gene_names_refseq": "fb30f01; uba1; ube1; wu:fa01e08; wu:fb30f01; wu:fi21c11; wu:fj14g11; zgc:66143", "protein_names_uniprotkb": "E1 ubiquitin-activating enzyme; 6.2.1.45; Ubiquitin-activating enzyme E1", "protein_names_refseq": "ubiquitin-like modifier-activating enzyme 1 isoform X1", "tax_id": 7955, "disease": "VEXAS syndrome (Disease Ontology:DOID:0080828); X-linked spinal muscular atrophy 2 (Disease Ontology:DOID:0111827)", "pathway": " (R-DRE-8866652); (R-DRE-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RCA1", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;2.3.2.34;2.3.2.26;6.2.1.45;2.3.2.31;2.3.2.23;3.4.19.12;2.3.2.25;6.2.1.64", "go_molecular_function": "GO:0005524 ATP binding;GO:0004839 ubiquitin activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007409 axonogenesis;GO:0006974 DNA damage response;GO:0050727 regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B975-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9I4-1", "uniprot_id": "A0A8M2B9I4_DANRE", "mass": 43316.0, "length": 398, "protein_name": "E3 ubiquitin-protein ligase RNF34", "gene_name": "rnf34b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005162485", "gene_names_uniprotkb": "rnf34b; zgc:171755", "gene_names_refseq": "rnf34b; zgc:171755", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF34; 2.3.2.27; RING finger protein 34; RING-type E3 ubiquitin transferase RNF34", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B9I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVL2-1", "uniprot_id": "WDR24_DANRE", "mass": 88855.0, "length": 779, "protein_name": "GATOR2 complex protein WDR24", "gene_name": "wdr24", "organism": "Zebrafish", "refseq_name": "GATOR2 complex protein WDR24", "refseq_ac": "NP_998228", "gene_names_uniprotkb": "wdr24; wu:fd05f12; zgc:55946", "gene_names_refseq": "wdr24; wu:fd05f12; zgc:55946", "protein_names_uniprotkb": "GATOR2 complex protein WDR24; 2.3.2.27", "protein_names_refseq": "GATOR complex protein WDR24; GATOR2 complex protein WDR24; WD repeat-containing protein 24", "tax_id": 7955, "disease": "", "pathway": " (dre:406336); (R-DRE-9639288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505374, SAMEA3505379 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045501.1., [RefSeq]; Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.1.2.2;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006914 autophagy;GO:0031669 cellular response to nutrient levels;GO:0016239 positive regulation of macroautophagy;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVL2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JH47-1", "uniprot_id": "CDK8_DANRE", "mass": 53234.0, "length": 464, "protein_name": "Cyclin-dependent kinase 8", "gene_name": "cdk8", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "cdk8; wu:fk95h11", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 8; 2.7.11.22; 2.7.11.23; Cell division protein kinase 8; Mediator complex subunit cdk8; Mediator of RNA polymerase II transcription subunit cdk8", "protein_names_refseq": "", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 87 (Disease Ontology:DOID:0112221); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12031503", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:1990508 CKM complex", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8JH47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA52-1", "uniprot_id": "A0A8M2BA52_DANRE", "mass": 25039.0, "length": 223, "protein_name": "Pentraxin family member", "gene_name": "crp2", "organism": "Zebrafish", "refseq_name": "C-reactive protein 2 isoform X1", "refseq_ac": "XP_005162934", "gene_names_uniprotkb": "crp2; si:ch211-234p6.13; wu:fi20c07", "gene_names_refseq": "crp2; si:ch211-234p6.13; wu:fi20c07", "protein_names_uniprotkb": "Pentraxin family member", "protein_names_refseq": "C-reactive protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:327615)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16630661;22079493;24683187;25592778;25835394;30547092;30653529;31782996;35377459;36622851", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0051607 defense response to virus;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BA52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA79-1", "uniprot_id": "A0A8M2BA79_DANRE", "mass": 64549.0, "length": 586, "protein_name": "Pyruvate kinase", "gene_name": "pkmb", "organism": "Zebrafish", "refseq_name": "pyruvate kinase M1/2b isoform X1", "refseq_ac": "XP_005163170", "gene_names_uniprotkb": "pkmb; pkm2b; zgc:92037", "gene_names_refseq": "pkm2b; pkmb; zgc:92037", "protein_names_uniprotkb": "Pyruvate kinase; 2.7.1.40", "protein_names_refseq": "pyruvate kinase M1/2b isoform X1", "tax_id": 7955, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hypertension (Disease Ontology:DOID:10763)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005163170.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.40", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030955 potassium ion binding;GO:0004743 pyruvate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0002040 sprouting angiogenesis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BA79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAJ2-1", "uniprot_id": "A0A8M2BAJ2_DANRE", "mass": 50818.0, "length": 453, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr140", "organism": "Zebrafish", "refseq_name": "pim proto-oncogene, serine/threonine kinase, related 140 isoform X1", "refseq_ac": "XP_005163403", "gene_names_uniprotkb": "pimr140; si:dkey-236a14.6", "gene_names_refseq": "pimr140; si:dkey-236a14.6", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "pim proto-oncogene, serine/threonine kinase, related 140 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:567487)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27011661", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BAJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAJ8-1", "uniprot_id": "A0A8M2BAJ8_DANRE", "mass": 88493.0, "length": 772, "protein_name": "Phosphoinositide phospholipase C", "gene_name": "plcd1b", "organism": "Zebrafish", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1", "refseq_ac": "XP_005163413", "gene_names_uniprotkb": "plcd1b; Plcd1; fj78d10; wu:fj78d10; zgc:55868", "gene_names_refseq": "Plcd1; fj78d10; plcd1b; wu:fj78d10; zgc:55868", "protein_names_uniprotkb": "Phosphoinositide phospholipase C; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1", "tax_id": 7955, "disease": "nonsyndromic congenital nail disorder 3 (Disease Ontology:DOID:0080081); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.11", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAM8-1", "uniprot_id": "A0A8M2BAM8_DANRE", "mass": 91847.0, "length": 824, "protein_name": "Potassium voltage-gated channel subfamily B member 2", "gene_name": "kcnb2a", "organism": "Zebrafish", "refseq_name": "potassium voltage-gated channel subfamily B member 2", "refseq_ac": "XP_005163503", "gene_names_uniprotkb": "kcnb2a", "gene_names_refseq": "kcnb2a", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 2", "protein_names_refseq": "potassium voltage-gated channel subfamily B member 2", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (dre:555921)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0V2U3", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAN1-1", "uniprot_id": "A0A8M2BAN1_DANRE", "mass": 104598.0, "length": 941, "protein_name": "phosphatidate phosphatase", "gene_name": "lpin2", "organism": "Zebrafish", "refseq_name": "phosphatidate phosphatase LPIN2 isoform X1", "refseq_ac": "XP_005163511", "gene_names_uniprotkb": "lpin2", "gene_names_refseq": "lpin2", "protein_names_uniprotkb": "phosphatidate phosphatase; 3.1.3.4", "protein_names_refseq": "phosphatidate phosphatase LPIN2 isoform X1", "tax_id": 7955, "disease": "Majeed syndrome (Disease Ontology:DOID:0061224); myoglobinuria (Disease Ontology:DOID:0080108); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:558422)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.4;3.1.3.106;3.6.1.75", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BB25-1", "uniprot_id": "A0A8M2BB25_DANRE", "mass": 96205.0, "length": 840, "protein_name": "V-type proton ATPase subunit a", "gene_name": "atp6v0a1a", "organism": "Zebrafish", "refseq_name": "V-type proton ATPase 116 kDa subunit a isoform X1", "refseq_ac": "XP_005163855", "gene_names_uniprotkb": "atp6v0a1a; atp6v0a1; wu:fc25b09; zgc:76965", "gene_names_refseq": "atp6v0a1a; atp6v0a1; wu:fc25b09; zgc:76965", "protein_names_uniprotkb": "V-type proton ATPase subunit a", "protein_names_refseq": "V-type proton ATPase 116 kDa subunit a isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 104 (Disease Ontology:DOID:0070390); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005163855.1. COMPLETENESS: full length., [RefSeq]; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0001755 neural crest cell migration;GO:0007035 vacuolar acidification;GO:0001845 phagolysosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BB25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBA6-1", "uniprot_id": "A0A8M2BBA6_DANRE", "mass": 71376.0, "length": 642, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-1", "gene_name": "cacnb1", "organism": "Zebrafish", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-1 isoform X1", "refseq_ac": "XP_005163865", "gene_names_uniprotkb": "cacnb1; zgc:91982", "gene_names_refseq": "cacnb1; zgc:91982", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-1; Calcium channel voltage-dependent subunit beta 1", "protein_names_refseq": "voltage-dependent L-type calcium channel subunit beta-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005163865.1. COMPLETENESS: full length., [RefSeq]; Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0042383 sarcolemma;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0070978 voltage-gated calcium channel complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBG2-1", "uniprot_id": "A0A8M2BBG2_DANRE", "mass": 53894.0, "length": 455, "protein_name": "Nucleobindin-1", "gene_name": "nucb1", "organism": "Zebrafish", "refseq_name": "nucleobindin-1 isoform X1", "refseq_ac": "XP_005164008", "gene_names_uniprotkb": "nucb1; zgc:153192", "gene_names_refseq": "nucb1; zgc:153192", "protein_names_uniprotkb": "Nucleobindin-1", "protein_names_refseq": "nucleobindin-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005164008.1. COMPLETENESS: full length., [RefSeq]; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBI5-1", "uniprot_id": "A0A8M2BBI5_DANRE", "mass": 64511.0, "length": 572, "protein_name": "Glucosidase 2 subunit beta", "gene_name": "prkcsh", "organism": "Zebrafish", "refseq_name": "glucosidase 2 subunit beta isoform X1", "refseq_ac": "XP_005164280", "gene_names_uniprotkb": "prkcsh; zgc:55653", "gene_names_refseq": "prkcsh; zgc:55653", "protein_names_uniprotkb": "Glucosidase 2 subunit beta", "protein_names_refseq": "glucosidase 2 subunit beta isoform X1", "tax_id": 7955, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic liver disease 1 (Disease Ontology:DOID:0060980); liver disease (Disease Ontology:DOID:409)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0017177 glucosidase II complex", "go_biological_process": "GO:0001889 liver development;GO:0006491 N-glycan processing;GO:0048793 pronephros development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBY7-1", "uniprot_id": "A0A8M2BBY7_DANRE", "mass": 54080.0, "length": 473, "protein_name": "Tyrosine 3-monooxygenase", "gene_name": "th2", "organism": "Zebrafish", "refseq_name": "tyrosine hydroxylase 2 isoform X1", "refseq_ac": "XP_005164791", "gene_names_uniprotkb": "th2", "gene_names_refseq": "th2", "protein_names_uniprotkb": "Tyrosine 3-monooxygenase; 1.14.16.2; Tyrosine 3-hydroxylase", "protein_names_refseq": "tyrosine hydroxylase 2 isoform X1", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays an important role in the physiology of adrenergic neurons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.16.2", "go_molecular_function": "GO:0004510 tryptophan 5-monooxygenase activity;GO:0005506 iron ion binding;GO:0004511 tyrosine 3-monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043204 perikaryon;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006585 dopamine biosynthetic process from tyrosine;GO:0007617 mating behavior;GO:0050890 cognition;GO:0001963 synaptic transmission, dopaminergic;GO:0042416 dopamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BC73-1", "uniprot_id": "A0A8M2BC73_DANRE", "mass": 25235.0, "length": 225, "protein_name": "Protein lin-7 homolog", "gene_name": "lin7a", "organism": "Zebrafish", "refseq_name": "protein lin-7 homolog A isoform X1", "refseq_ac": "XP_005164923", "gene_names_uniprotkb": "lin7a; lin7b; zgc:73090", "gene_names_refseq": "lin7a; lin7b; zgc:73090", "protein_names_uniprotkb": "Protein lin-7 homolog", "protein_names_refseq": "protein lin-7 homolog A isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BC73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCH8-1", "uniprot_id": "A0A8M2BCH8_DANRE", "mass": 97808.0, "length": 859, "protein_name": "Transient receptor potential cation channel subfamily V member 4 isoform X1", "gene_name": "trpv4", "organism": "Zebrafish", "refseq_name": "transient receptor potential cation channel subfamily V member 4 isoform X1", "refseq_ac": "XP_005165208", "gene_names_uniprotkb": "trpv4; wu:fp52e02", "gene_names_refseq": "trpv4; wu:fp52e02", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 4 isoform X1", "protein_names_refseq": "transient receptor potential cation channel subfamily V member 4 isoform X1", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease axonal type 2C (Disease Ontology:DOID:0110182); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); autosomal dominant distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0111215); metatropic dysplasia (Disease Ontology:DOID:0111514); parastremmatic dwarfism (Disease Ontology:DOID:0111539); scapuloperoneal spinal muscular atrophy (Disease Ontology:DOID:0111552); spondyloepiphyseal dysplasia Maroteaux type (Disease Ontology:DOID:0111553); spondylometaphyseal dysplasia Kozlowski type (Disease Ontology:DOID:0111554); osteonecrosis (Disease Ontology:DOID:10159); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0006970 response to osmotic stress;GO:0097704 cellular response to oscillatory fluid shear stress;GO:0007231 osmosensory signaling pathway;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98TZ8-1", "uniprot_id": "FLOT2_DANRE", "mass": 46921.0, "length": 428, "protein_name": "Flotillin-2a", "gene_name": "flot2a", "organism": "Zebrafish", "refseq_name": "flotillin-2a", "refseq_ac": "NP_998240", "gene_names_uniprotkb": "flot2a; fb48a04; im:7143869; wu:fb48a04; zgc:55821", "gene_names_refseq": "fb48a04; flot2a; im:7143869; wu:fb48a04; zgc:55821", "protein_names_uniprotkb": "Flotillin-2a; REG-1; Reggie-1a", "protein_names_refseq": "REG-1; flotillin-2a; reggie-1a", "tax_id": 7955, "disease": "", "pathway": " (dre:245698)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11821916;15690489;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01010673.1, GDQQ01005616.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1, EB850170.1, BC165232.1, EB834549.1, AW174527.1 and EB909858.1. On or before May 8, 2009 this sequence version replaced XP_688309.1, NP_998240.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of reggie mRNA and protein expression patterns during early zebrafish development revealed re-2a can be observed in differentiating neurons in the brain, spinal cord, and neurogenic placodes., [RefSeq, PubMed]; May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5DDN8;Q803F9", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0030139 endocytic vesicle;GO:0016600 flotillin complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0045661 regulation of myoblast differentiation;GO:2000047 regulation of cell-cell adhesion mediated by cadherin;GO:1904086 regulation of epiboly involved in gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q98TZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCS1-1", "uniprot_id": "A0A8M2BCS1_DANRE", "mass": 83502.0, "length": 762, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "mark4a", "organism": "Zebrafish", "refseq_name": "MAP/microtubule affinity-regulating kinase 4 isoform X1", "refseq_ac": "XP_021332218", "gene_names_uniprotkb": "mark4a", "gene_names_refseq": "mark4a", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 4 isoform X1", "tax_id": 7955, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:569346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCV1-1", "uniprot_id": "A0A8M2BCV1_DANRE", "mass": 96729.0, "length": 859, "protein_name": "Dynamin-2", "gene_name": "dnm1b", "organism": "Zebrafish", "refseq_name": "dynamin-1 isoform X1", "refseq_ac": "XP_005165639", "gene_names_uniprotkb": "dnm1b; dnm1; si:ch73-310g9.3", "gene_names_refseq": "dnm1b; dnm1; si:ch73-310g9.3", "protein_names_uniprotkb": "Dynamin-2; 3.6.5.5", "protein_names_refseq": "dynamin-1 isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 31B (Disease Ontology:DOID:0070376); developmental and epileptic encephalopathy 31A (Disease Ontology:DOID:0080437); Alzheimer's disease (Disease Ontology:DOID:10652); generalized epilepsy (Disease Ontology:DOID:1827); collagen disease (Disease Ontology:DOID:854)", "pathway": " (dre:100333543)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24643020;26469318;27189481;28252024;34083748;37031448", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005874 microtubule;GO:0005905 clathrin-coated pit;GO:0014069 postsynaptic density;GO:0055037 recycling endosome", "go_biological_process": "GO:0006909 phagocytosis;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BCV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCV8-1", "uniprot_id": "A0A8M2BCV8_DANRE", "mass": 51345.0, "length": 454, "protein_name": "Prolactin receptor", "gene_name": "prlrb", "organism": "Zebrafish", "refseq_name": "prolactin receptor b isoform X1", "refseq_ac": "XP_005165667", "gene_names_uniprotkb": "prlrb; PRLR; prlr.b; si:ch211-261c8.2", "gene_names_refseq": "prlr.b; prlrb; si:ch211-261c8.2", "protein_names_uniprotkb": "Prolactin receptor; PRL-R", "protein_names_refseq": "prolactin receptor b isoform X1", "tax_id": 7955, "disease": "familial medullary thyroid carcinoma (Disease Ontology:DOID:0050547); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; This is a receptor for the anterior pituitary hormone prolactin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCZ3-1", "uniprot_id": "A0A8M2BCZ3_DANRE", "mass": 88066.0, "length": 786, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "rps6ka4", "organism": "Zebrafish", "refseq_name": "ribosomal protein S6 kinase alpha-4 isoform X1", "refseq_ac": "XP_005165672", "gene_names_uniprotkb": "rps6ka4; si:dkey-273o13.5", "gene_names_refseq": "rps6ka4; si:dkey-273o13.5", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase alpha-4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:561959)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24240475;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0038202 TORC1 signaling;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BCZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BD93-1", "uniprot_id": "A0A8M2BD93_DANRE", "mass": 95339.0, "length": 847, "protein_name": "Choline transporter-like protein 2", "gene_name": "slc44a2", "organism": "Zebrafish", "refseq_name": "choline transporter-like protein 2 isoform X1", "refseq_ac": "XP_005165806", "gene_names_uniprotkb": "slc44a2", "gene_names_refseq": "slc44a2", "protein_names_uniprotkb": "Choline transporter-like protein 2; Solute carrier family 44 member 2", "protein_names_refseq": "choline transporter-like protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:324345)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005165806.1. COMPLETENESS: full length., [RefSeq]; Choline transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BD93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDG3-1", "uniprot_id": "A0A8M2BDG3_DANRE", "mass": 48141.0, "length": 424, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "stk25a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase 25a isoform X1", "refseq_ac": "XP_005165982", "gene_names_uniprotkb": "stk25a; zgc:92836", "gene_names_refseq": "stk25a; zgc:92836", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase 25a isoform X1", "tax_id": 7955, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (dre:449653)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20592472;22182521;26469318;28252024;36291156", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007507 heart development;GO:0035556 intracellular signal transduction;GO:0003401 axis elongation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BDG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3H1-1", "uniprot_id": "DCTN2_DANRE", "mass": 44625.0, "length": 405, "protein_name": "Dynactin subunit 2", "gene_name": "dctn2", "organism": "Zebrafish", "refseq_name": "dynactin subunit 2", "refseq_ac": "NP_957460", "gene_names_uniprotkb": "dctn2; dynamitin; zgc:63867", "gene_names_refseq": "dctn2; dynamitin; zgc:63867", "protein_names_uniprotkb": "Dynactin subunit 2", "protein_names_refseq": "dynactin subunit 2; p50/dynamitin", "tax_id": 7955, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:394141); (R-DRE-380320)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19666822;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053120.1, DQ141218.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053120.1., [RefSeq]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results indicate that the p50 component of the dynactin complex is essential for the survival of sensory neurons and the maintenance of ganglion cell axons, and functions as a major determinant of apicobasal polarity in retinal radial glia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q07DR0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0016020 membrane;GO:0031982 vesicle", "go_biological_process": "GO:0030719 P granule organization;GO:0045494 photoreceptor cell maintenance;GO:0007052 mitotic spindle organization;GO:0010001 glial cell differentiation;GO:0001754 eye photoreceptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7T3H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEB4-1", "uniprot_id": "A0A8M2BEB4_DANRE", "mass": 143817.0, "length": 1299, "protein_name": "Calcium-transporting ATPase", "gene_name": "atp2b3a", "organism": "Zebrafish", "refseq_name": "plasma membrane calcium-transporting ATPase 3a isoform X1", "refseq_ac": "XP_005166875", "gene_names_uniprotkb": "atp2b3a; atp2b3; pmca3a; wu:fk54d07; zgc:92885", "gene_names_refseq": "atp2b3a; atp2b3; pmca3a; wu:fk54d07; zgc:92885", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "plasma membrane calcium-transporting ATPase 3a isoform X1", "tax_id": 7955, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); X-linked spinocerebellar ataxia 1 (Disease Ontology:DOID:0111829); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "17915033;21947502;24180662;25062015;27189481;28252024;29234032;31415728;31468037;35886843", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G6S1", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BEB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BER7-1", "uniprot_id": "A0A8M2BER7_DANRE", "mass": 98442.0, "length": 897, "protein_name": "Mitogen-activated protein kinase kinase kinase 12", "gene_name": "map3k12", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase 12", "refseq_ac": "NP_996977", "gene_names_uniprotkb": "map3k12; zgc:77370", "gene_names_refseq": "map3k12; zgc:77370", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 12; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 12", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.26554011.1, SRR32588729.3245969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On or before Jul 28, 2025 this sequence version replaced XP_005167446.1, NP_996977.1., [RefSeq]; May be an activator of the JNK/SAPK pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BER7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BF24-1", "uniprot_id": "A0A8M2BF24_DANRE", "mass": 60815.0, "length": 547, "protein_name": "Uridine-cytidine kinase", "gene_name": "uckl1a", "organism": "Zebrafish", "refseq_name": "uridine-cytidine kinase-like 1a isoform X1", "refseq_ac": "XP_005167107", "gene_names_uniprotkb": "uckl1a; si:dkey-70p6.2; uckl1; zK70P6.2", "gene_names_refseq": "si:dkey-70p6.2; uckl1a; uckl1; zK70P6.2", "protein_names_uniprotkb": "Uridine-cytidine kinase; 2.7.1.48", "protein_names_refseq": "uridine-cytidine kinase-like 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570547)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May contribute to UTP accumulation needed for blast transformation and proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BF24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFC1-1", "uniprot_id": "A0A8M2BFC1_DANRE", "mass": 34192.0, "length": 304, "protein_name": "Short stature homeobox protein isoform X1", "gene_name": "shox", "organism": "Zebrafish", "refseq_name": "short stature homeobox protein isoform X1", "refseq_ac": "XP_005167911", "gene_names_uniprotkb": "shox; si:ch211-134k13.1; zgc:123182", "gene_names_refseq": "shox; si:ch211-134k13.1; zgc:123182", "protein_names_uniprotkb": "Short stature homeobox protein isoform X1", "protein_names_refseq": "short stature homeobox protein isoform X1", "tax_id": 7955, "disease": "Leri-Weill dyschondrosteosis (Disease Ontology:DOID:0060847); SHOX-related short stature (Disease Ontology:DOID:0112120); Werner syndrome (Disease Ontology:DOID:5688)", "pathway": " (dre:664748)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21731768;25483930;26469318;27189481;27593944;28642734;28705894;34122528;36114168;37184369", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0001503 ossification;GO:0030282 bone mineralization;GO:0033339 pectoral fin development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BFC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BG80-1", "uniprot_id": "A0A8M2BG80_DANRE", "mass": 112106.0, "length": 1033, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "rnf111", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase Arkadia isoform X1", "refseq_ac": "XP_005168980", "gene_names_uniprotkb": "rnf111", "gene_names_refseq": "rnf111", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase Arkadia isoform X1", "tax_id": 7955, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168980.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0046332 SMAD binding;GO:0032184 SUMO polymer binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0021501 prechordal plate formation;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0055113 epiboly involved in gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BG80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3S3-1", "uniprot_id": "CHSTB_DANRE", "mass": 40998.0, "length": 352, "protein_name": "Carbohydrate sulfotransferase 11", "gene_name": "chst11", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "chst11; C4ST1", "gene_names_refseq": "", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 11; 2.8.2.5; C4ST-1; C4ST1; Chondroitin 4-O-sulfotransferase 1; Chondroitin 4-sulfotransferase 1; zC4ST-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-2022870)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.5", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0047756 chondroitin 4-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0007517 muscle organ development;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0008045 motor neuron axon guidance;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7T3S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH38-1", "uniprot_id": "A0A8M2BH38_DANRE", "mass": 263683.0, "length": 2394, "protein_name": "Retinitis pigmentosa 1-like 1 protein", "gene_name": "rp1l1a", "organism": "Zebrafish", "refseq_name": "retinitis pigmentosa 1-like 1 protein", "refseq_ac": "XP_005169865", "gene_names_uniprotkb": "rp1l1a", "gene_names_refseq": "rp1l1a", "protein_names_uniprotkb": "Retinitis pigmentosa 1-like 1 protein", "protein_names_refseq": "retinitis pigmentosa 1-like 1 protein", "tax_id": 7955, "disease": "occult macular dystrophy (Disease Ontology:DOID:0050578); retinitis pigmentosa 88 (Disease Ontology:DOID:0112145); eye disease (Disease Ontology:DOID:5614)", "pathway": " (dre:101882236)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F630", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0035845 photoreceptor cell outer segment organization;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH70-1", "uniprot_id": "A0A8M2BH70_DANRE", "mass": 199266.0, "length": 1804, "protein_name": "Nidogen-2 isoform X1", "gene_name": "nid2a", "organism": "Zebrafish", "refseq_name": "nidogen-2 isoform X1", "refseq_ac": "XP_005169904", "gene_names_uniprotkb": "nid2a", "gene_names_refseq": "nid2a", "protein_names_uniprotkb": "Nidogen-2 isoform X1", "protein_names_refseq": "nidogen-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:322921)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005604 basement membrane", "go_biological_process": "GO:0061386 closure of optic fissure;GO:0030855 epithelial cell differentiation;GO:0007160 cell-matrix adhesion;GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BH70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH77-1", "uniprot_id": "A0A8M2BH77_DANRE", "mass": 68884.0, "length": 608, "protein_name": "Histidine decarboxylase", "gene_name": "hdc", "organism": "Zebrafish", "refseq_name": "histidine decarboxylase isoform 1", "refseq_ac": "NP_001429008", "gene_names_uniprotkb": "hdc", "gene_names_refseq": "hdc", "protein_names_uniprotkb": "Histidine decarboxylase; 4.1.1.22", "protein_names_refseq": "histidine decarboxylase isoform 1", "tax_id": 7955, "disease": "Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588735.1638315.1, SRR32588718.16653386.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jul 24, 2025 this sequence version replaced XP_005169965.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004398 histidine decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0007420 brain development;GO:0009416 response to light stimulus;GO:0007411 axon guidance;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH93-1", "uniprot_id": "A0A8M2BH93_DANRE", "mass": 85526.0, "length": 735, "protein_name": "DNA topoisomerase I", "gene_name": "zgc:173742", "organism": "Zebrafish", "refseq_name": "DNA topoisomerase I, mitochondrial", "refseq_ac": "XP_002665372", "gene_names_uniprotkb": "zgc:173742", "gene_names_refseq": "zgc:173742", "protein_names_uniprotkb": "DNA topoisomerase I; 5.6.2.1; DNA topoisomerase 1", "protein_names_refseq": "DNA topoisomerase I, mitochondrial", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:334557)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002665372.1. COMPLETENESS: full length., [RefSeq]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0007059 chromosome segregation;GO:0006260 DNA replication;GO:0006265 DNA topological change", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHQ8-1", "uniprot_id": "A0A8M2BHQ8_DANRE", "mass": 139828.0, "length": 1255, "protein_name": "Tight junction protein ZO-3", "gene_name": "tjp3", "organism": "Zebrafish", "refseq_name": "tight junction protein ZO-3", "refseq_ac": "NP_001315269", "gene_names_uniprotkb": "tjp3; cb766; wu:fj93c08; zo-3", "gene_names_refseq": "cb766; tjp3; wu:fj93c08; zo-3", "protein_names_uniprotkb": "Tight junction protein ZO-3", "protein_names_refseq": "tight junction protein ZO-3", "tax_id": 7955, "disease": "", "pathway": " (dre:373089)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17632043;18275946;23499359;25460834;25867848;26469318;31006648;31495257;31675500;33535128;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01011759.1, SRR26395028.1282700.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1. On Jun 12, 2016 this sequence version replaced XP_005170498.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio, [RefSeq, PubMed]; Tjp3/Zo-3 is critical for barrier function of the enveloping cell layer and osmoregulation in early stages of zebrafish development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1R3X0", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0098609 cell-cell adhesion;GO:0090557 establishment of endothelial intestinal barrier;GO:0050891 multicellular organismal-level water homeostasis;GO:0045216 cell-cell junction organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M2BHQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHS4-1", "uniprot_id": "A0A8M2BHS4_DANRE", "mass": 43058.0, "length": 367, "protein_name": "Guanine nucleotide-binding protein subunit alpha", "gene_name": "gna15.1", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein subunit alpha-15.1 isoform X1", "refseq_ac": "XP_005170507", "gene_names_uniprotkb": "gna15.1; zgc:100942", "gene_names_refseq": "gna15.1; zgc:100942", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha", "protein_names_refseq": "guanine nucleotide-binding protein subunit alpha-15.1 isoform X1", "tax_id": 7955, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (dre:445232)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19164534;21242316;24926785;26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005170507.1. COMPLETENESS: full length., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0001508 action potential;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BHS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHX0-1", "uniprot_id": "A0A8M2BHX0_DANRE", "mass": 36995.0, "length": 322, "protein_name": "Laforin", "gene_name": "epm2a", "organism": "Zebrafish", "refseq_name": "laforin", "refseq_ac": "XP_005170620", "gene_names_uniprotkb": "epm2a", "gene_names_refseq": "epm2a", "protein_names_uniprotkb": "Laforin; 3.1.3.16; 3.1.3.48; Glucan phosphatase; Lafora PTPase", "protein_names_refseq": "laforin", "tax_id": 7955, "disease": "Lafora disease 1 (Disease Ontology:DOID:0070660); Lafora disease (Disease Ontology:DOID:3534); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (dre:100535304)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004722 protein serine/threonine phosphatase activity;GO:2001070 starch binding;GO:0019203 carbohydrate phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006796 phosphate-containing compound metabolic process;GO:0006914 autophagy;GO:0005978 glycogen biosynthetic process;GO:0070873 regulation of glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIB6-1", "uniprot_id": "DSG2L_DANRE", "mass": 117994.0, "length": 1063, "protein_name": "Desmoglein-2-like protein", "gene_name": "dsg2l", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "dsg2l; dsgb", "gene_names_refseq": "", "protein_names_uniprotkb": "Desmoglein-2-like protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); pemphigus vulgaris (Disease Ontology:DOID:0060851); keratosis palmoplantaris striata 1 (Disease Ontology:DOID:0081108); arrhythmogenic right ventricular dysplasia 10 (Disease Ontology:DOID:0110081); dilated cardiomyopathy 1BB (Disease Ontology:DOID:0110458); hypotrichosis 6 (Disease Ontology:DOID:0110703); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypotrichosis (Disease Ontology:DOID:4535); multiple myeloma (Disease Ontology:DOID:9538); alopecia (Disease Ontology:DOID:987)", "pathway": " (dre:100884140)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22235774;23594743;27189481", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "H2EQR7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0045216 cell-cell junction organization;GO:0055113 epiboly involved in gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BIB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ26-1", "uniprot_id": "A0A8M2BJ26_DANRE", "mass": 51398.0, "length": 465, "protein_name": "Apolipoprotein L1 isoform X1", "gene_name": "apol1", "organism": "Zebrafish", "refseq_name": "apolipoprotein L1 isoform X1", "refseq_ac": "XP_005171358", "gene_names_uniprotkb": "apol1; si:rp71-1g18.12; wu:fa95b12; wu:fc30h04", "gene_names_refseq": "apol1; si:rp71-1g18.12; wu:fa95b12; wu:fc30h04", "protein_names_uniprotkb": "Apolipoprotein L1 isoform X1", "protein_names_refseq": "apolipoprotein L1 isoform X1", "tax_id": 7955, "disease": "kidney disease (Disease Ontology:DOID:557)", "pathway": " (dre:560340)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16109975;25298528;26030930;26147622;27138898;27189481;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process;GO:0032835 glomerulus development;GO:0003094 glomerular filtration;GO:0072015 podocyte development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2BJ26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIW9-1", "uniprot_id": "A0A8M2BIW9_DANRE", "mass": 51107.0, "length": 452, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "csnk1g2a", "organism": "Zebrafish", "refseq_name": "casein kinase I isoform X1", "refseq_ac": "XP_005171263", "gene_names_uniprotkb": "csnk1g2a; csnk1g2; fj97g11; wu:fj97g11; wz8345; zgc:110719", "gene_names_refseq": "csnk1g2a; csnk1g2; fj97g11; wu:fj97g11; wz8345; zgc:110719", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "casein kinase I isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:554152)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJK9-1", "uniprot_id": "A0A8M2BJK9_DANRE", "mass": 127381.0, "length": 1137, "protein_name": "TSC complex subunit 1a isoform X1", "gene_name": "tsc1a", "organism": "Zebrafish", "refseq_name": "TSC complex subunit 1a isoform X1", "refseq_ac": "XP_005171852", "gene_names_uniprotkb": "tsc1a; fa99f04; wu:fa99f04; zgc:63657", "gene_names_refseq": "fa99f04; tsc1a; wu:fa99f04; zgc:63657", "protein_names_uniprotkb": "TSC complex subunit 1a isoform X1", "protein_names_refseq": "TSC complex subunit 1a isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); spinal disease (Disease Ontology:DOID:0060564); anterior segment dysgenesis (Disease Ontology:DOID:0060648); tuberous sclerosis 1 (Disease Ontology:DOID:0080324); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); intellectual disability (Disease Ontology:DOID:1059); tuberous sclerosis (Disease Ontology:DOID:13515); breast cancer (Disease Ontology:DOID:1612); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:337167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005171852.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QHE1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0033596 TSC1-TSC2 complex", "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0032006 regulation of TOR signaling;GO:0048793 pronephros development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJD0-1", "uniprot_id": "A0A8M2BJD0_DANRE", "mass": 79115.0, "length": 701, "protein_name": "protein-arginine deiminase", "gene_name": "padi2", "organism": "Zebrafish", "refseq_name": "protein-arginine deiminase type-2 isoform X1", "refseq_ac": "XP_005172154", "gene_names_uniprotkb": "padi2; sb:cb968; zgc:66317", "gene_names_refseq": "padi2; sb:cb968; zgc:66317", "protein_names_uniprotkb": "protein-arginine deiminase; 3.5.3.15", "protein_names_refseq": "protein-arginine deiminase type-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005172154.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the deimination of arginine residues of proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.3.15", "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0005509 calcium ion binding;GO:0140794 histone arginine deiminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJN0-1", "uniprot_id": "A0A8M2BJN0_DANRE", "mass": 40183.0, "length": 350, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "zgc:63587", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC393431", "refseq_ac": "NP_956753", "gene_names_uniprotkb": "zgc:63587", "gene_names_refseq": "zgc:63587", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein LOC393431", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01010940.1, GFIL01034815.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On or before Aug 4, 2025 this sequence version replaced XP_005172514.1, NP_956753.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0032154 cleavage furrow;GO:0030496 midbody", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BJN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJP0-1", "uniprot_id": "A0A8M2BJP0_DANRE", "mass": 85940.0, "length": 757, "protein_name": "Mitofusin-2", "gene_name": "mfn2", "organism": "Zebrafish", "refseq_name": "mitofusin-2", "refseq_ac": "NP_001121726", "gene_names_uniprotkb": "mfn2; mg:cb01g09; si:dkeyp-104h9.2; wu:fb79a11", "gene_names_refseq": "mfn2; mg:cb01g09; si:dkeyp-104h9.2; wu:fb79a11", "protein_names_uniprotkb": "Mitofusin-2", "protein_names_refseq": "mitofusin-2", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); carotid stenosis (Disease Ontology:DOID:13001); multiple symmetric lipomatosis (Disease Ontology:DOID:14116); primary pulmonary hypertension (Disease Ontology:DOID:14557); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary fibrosis (Disease Ontology:DOID:3770); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:567448); (R-DRE-5205685); (R-DRE-9013419); (R-DRE-983231)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "19584314;20951042;22814267;23516612;23840650;37107331;37756160;38530354;38710511;39175772", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.2179642.1, SRR26395017.579285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_695837.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WIN6", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development;GO:0030097 hemopoiesis;GO:0008053 mitochondrial fusion;GO:0051646 mitochondrion localization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BJP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUW7-1", "uniprot_id": "MDM4_DANRE", "mass": 55241.0, "length": 496, "protein_name": "Protein Mdm4", "gene_name": "mdm4", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mdm4; mdmx; wu:fa09h09; wu:fi33d10", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4", "protein_names_refseq": "", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:334932); (R-DRE-2559580); (R-DRE-2559585); (R-DRE-6804756); (R-DRE-6804757); (R-DRE-69541)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "16109975;17938582;23069659;24240475;25503746;33279959;34315984;34611130;34829928;38382674", "class_list": "", "function": "Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains., [UniProtKB, UniProtKB, UniProtKB]; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V944", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0005634 nucleus", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0050821 protein stabilization;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZUW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKA1-1", "uniprot_id": "A0A8M2BKA1_DANRE", "mass": 21690.0, "length": 196, "protein_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1", "gene_name": "bnip3", "organism": "Zebrafish", "refseq_name": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1", "refseq_ac": "XP_005173025", "gene_names_uniprotkb": "bnip3; fj49c01; nip3c; wu:fj49c01; zgc:198406", "gene_names_refseq": "bnip3; fj49c01; nip3c; wu:fj49c01; zgc:198406", "protein_names_uniprotkb": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1", "protein_names_refseq": "BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1", "tax_id": 7955, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0097345 mitochondrial outer membrane permeabilization;GO:0043068 positive regulation of programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKX2-1", "uniprot_id": "A0A8M2BKX2_DANRE", "mass": 196929.0, "length": 1824, "protein_name": "Lysine-specific demethylase", "gene_name": "kdm3b", "organism": "Zebrafish", "refseq_name": "lysine-specific demethylase 3B isoform X1", "refseq_ac": "XP_005173195", "gene_names_uniprotkb": "kdm3b", "gene_names_refseq": "kdm3b", "protein_names_uniprotkb": "Lysine-specific demethylase; 1.14.11.65", "protein_names_refseq": "lysine-specific demethylase 3B isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:326643)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005173195.1. COMPLETENESS: full length., [RefSeq]; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.65;1.14.99.66;1.14.11.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140683 histone H3K9me/H3K9me2 demethylase activity;GO:0031490 chromatin DNA binding;GO:0003712 transcription coregulator activity;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0000118 histone deacetylase complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0070988 demethylation;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BKX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKS8-1", "uniprot_id": "A0A8M2BKS8_DANRE", "mass": 111724.0, "length": 1003, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "ephb6", "organism": "Zebrafish", "refseq_name": "ephrin type-B receptor 5 isoform X1", "refseq_ac": "XP_005173575", "gene_names_uniprotkb": "ephb6", "gene_names_refseq": "ephb6", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "ephrin type-B receptor 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:572411)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BL72-1", "uniprot_id": "A0A8M2BL72_DANRE", "mass": 111537.0, "length": 1009, "protein_name": "Angiomotin isoform X1", "gene_name": "amot", "organism": "Zebrafish", "refseq_name": "angiomotin isoform X1", "refseq_ac": "XP_005173944", "gene_names_uniprotkb": "amot", "gene_names_refseq": "amot", "protein_names_uniprotkb": "Angiomotin isoform X1", "protein_names_refseq": "angiomotin isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563421); (R-DRE-2028269)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QFX4", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030027 lamellipodium;GO:0031410 cytoplasmic vesicle;GO:0070161 anchoring junction", "go_biological_process": "GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0001568 blood vessel development;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BL72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLI2-1", "uniprot_id": "A0A8M2BLI2_DANRE", "mass": 66475.0, "length": 580, "protein_name": "Alpha-(1,6)-fucosyltransferase", "gene_name": "fut8b", "organism": "Zebrafish", "refseq_name": "alpha-(1,6)-fucosyltransferase isoform X1", "refseq_ac": "XP_005173879", "gene_names_uniprotkb": "fut8b", "gene_names_refseq": "fut8b", "protein_names_uniprotkb": "Alpha-(1,6)-fucosyltransferase; 2.4.1.68", "protein_names_refseq": "alpha-(1,6)-fucosyltransferase isoform X1", "tax_id": 7955, "disease": "pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:100331714)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.68", "go_molecular_function": "GO:0046921 alpha-(1->6)-fucosyltransferase activity;GO:0017124 SH3 domain binding;GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AGL6-1", "uniprot_id": "A0A8M3AGL6_DANRE", "mass": 47654.0, "length": 423, "protein_name": "5-hydroxytryptamine receptor 4", "gene_name": "htr4", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 4 isoform X1", "refseq_ac": "XP_009289337", "gene_names_uniprotkb": "htr4", "gene_names_refseq": "htr4", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 4; Serotonin receptor 4", "protein_names_refseq": "5-hydroxytryptamine receptor 4 isoform X1", "tax_id": 7955, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (dre:101882850)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0010008 endosome membrane", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0032098 regulation of appetite;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AGL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AH32-1", "uniprot_id": "A0A8M3AH32_DANRE", "mass": 54787.0, "length": 503, "protein_name": "Beta-secretase 2 isoform X1", "gene_name": "bace2", "organism": "Zebrafish", "refseq_name": "beta-secretase 2 isoform X1", "refseq_ac": "XP_009289748", "gene_names_uniprotkb": "bace2; bace2l; fi26d02; wu:fi26d02; zbace; zgc:103530", "gene_names_refseq": "bace2l; bace2; fi26d02; wu:fi26d02; zbace; zgc:103530", "protein_names_uniprotkb": "Beta-secretase 2 isoform X1", "protein_names_refseq": "beta-secretase 2 isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0006509 membrane protein ectodomain proteolysis;GO:0016485 protein processing;GO:0050435 amyloid-beta metabolic process;GO:0097324 melanocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AH32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AIS0-1", "uniprot_id": "A0A8M3AIS0_DANRE", "mass": 107399.0, "length": 967, "protein_name": "Sodium/calcium exchanger 2b isoform X1", "gene_name": "slc8a2b", "organism": "Zebrafish", "refseq_name": "sodium/calcium exchanger 2b isoform X1", "refseq_ac": "XP_009290185", "gene_names_uniprotkb": "slc8a2b; si:dkeyp-109h9.1", "gene_names_refseq": "si:dkeyp-109h9.1; slc8a2b", "protein_names_uniprotkb": "Sodium/calcium exchanger 2b isoform X1", "protein_names_refseq": "sodium/calcium exchanger 2b isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity", "go_cellular_component": "GO:0030424 axon;GO:0098794 postsynapse;GO:0042383 sarcolemma", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0007154 cell communication;GO:0035725 sodium ion transmembrane transport;GO:1990034 calcium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AIS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90478-1", "uniprot_id": "L1CA1_DANRE", "mass": 132861.0, "length": 1197, "protein_name": "Neural cell adhesion molecule L1.1", "gene_name": "l1camb; nadl1.1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "l1camb; nadl1.1; L1.1; nadl1.1; wu:fa30h05", "gene_names_refseq": "", "protein_names_uniprotkb": "Neural cell adhesion molecule L1.1; N-CAM-L1.1; NCAM-L1.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); MASA syndrome (Disease Ontology:DOID:0060246); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); glioblastoma (Disease Ontology:DOID:3068); bipolar disorder (Disease Ontology:DOID:3312); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); uterine cancer (Disease Ontology:DOID:363); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8568941", "class_list": "", "function": "Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity)., [UniProtKB]; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 13, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0044295 axonal growth cone;GO:0030426 growth cone", "go_biological_process": "GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression;GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0045773 positive regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90478-1", "record_type": "protein" }, { "uniprot_canonical_ac": "R4GER2-1", "uniprot_id": "ATG4D_DANRE", "mass": 53363.0, "length": 485, "protein_name": "Cysteine protease atg4da", "gene_name": "atg4da", "organism": "Zebrafish", "refseq_name": "cysteine protease atg4da", "refseq_ac": "NP_001410735", "gene_names_uniprotkb": "atg4da; atg4d; im:7140072; si:ch211-212h16.5", "gene_names_refseq": "atg4da; atg4d; im:7140072; si:ch211-212h16.5", "protein_names_uniprotkb": "Cysteine protease atg4da; 3.4.22.-; Autophagy-related protein 4 homolog D-A", "protein_names_refseq": "autophagy-related protein 4 homolog D-A; cysteine protease atg4da", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:795933); (R-DRE-1632852)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23594743;25875846;26469318;27171500;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01013184.1, GDQQ01036168.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505383, SAMEA3505389 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV596358.1 and GDQH01013184.1. On Aug 15, 2023 this sequence version replaced XP_009292711.1., [RefSeq]; Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.22.-", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0098749 cerebellar neuron development;GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0016485 protein processing;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "R4GER2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Z08-1", "uniprot_id": "U119B_DANRE", "mass": 28009.0, "length": 243, "protein_name": "Protein unc-119 homolog B", "gene_name": "unc119b", "organism": "Zebrafish", "refseq_name": "protein unc-119 homolog B", "refseq_ac": "NP_997952", "gene_names_uniprotkb": "unc119b; id:ibd2212; si:dkey-117k10; unc119.1; unc119c; unc119; wu:fc47b02; zfUnc119b; zgc:111863", "gene_names_refseq": "id:ibd2212; unc119.1; unc119b; wu:fc47b02; zfUnc119b; zgc:111863", "protein_names_uniprotkb": "Protein unc-119 homolog B; Protein unc-119 homolog 1", "protein_names_refseq": "Unc119c; protein unc-119 homolog 1; protein unc-119 homolog B", "tax_id": 7955, "disease": "", "pathway": " (dre:338230); (R-DRE-5624138)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15593328;22085962;23594743;27079236", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF387342.1, BC162277.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF387342.1., [RefSeq]; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in localization of proteins to the primary cilium membrane., [UniProtKB, PubMed]; Our results suggest that Unc119c is the only Unc119 paralog that is highly specific to the retina in zebrafish. Unc119c and Arl3l2 proteins are important for the function of cones., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9C3N9;B3DG53;Q502S5", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0007399 nervous system development;GO:0042953 lipoprotein transport;GO:0060271 cilium assembly;GO:0070121 Kupffer's vesicle development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90Z08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803I8-1", "uniprot_id": "SYVN1_DANRE", "mass": 68757.0, "length": 625, "protein_name": "E3 ubiquitin-protein ligase synoviolin", "gene_name": "syvn1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "syvn1; hrd1; wu:fk91f10; zgc:55735; zgc:77108", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase synoviolin; 2.3.2.27; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (dre:335226); (R-DRE-5358346)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16109975;17560942;21911472;23800688;25188630;26469318;27851892;28252024", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NYA5", "ec_number_list": "3.6.4.6;2.3.2.27;3.1.-.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050821 protein stabilization;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q803I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X1WEM4-1", "uniprot_id": "TM63C_DANRE", "mass": 94430.0, "length": 825, "protein_name": "Osmosensitive cation channel TMEM63C", "gene_name": "tmem63c", "organism": "Zebrafish", "refseq_name": "calcium permeable stress-gated cation channel 1 isoform X1", "refseq_ac": "XP_005158939", "gene_names_uniprotkb": "tmem63c; csc1; si:dkey-120l3.1; si:dkey-7i21.1", "gene_names_refseq": "si:dkey-120l3.1; si:dkey-7i21.1; tmem63c", "protein_names_uniprotkb": "Osmosensitive cation channel TMEM63C; Calcium permeable stress-gated cation channel 1; Transmembrane protein 63c", "protein_names_refseq": "calcium permeable stress-gated cation channel 1 isoform X1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 87 (Disease Ontology:DOID:0070456); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (dre:100000800)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23594743;28252024;30900988;33577748", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (By similarity). In contrast to tmem63b, does not show phospholipid scramblase activity (By similarity). Required for the functional integrity of the kidney glomerular filtration barrier (PubMed:30900988)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:1990760 osmolarity-sensing monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0032835 glomerulus development;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "X1WEM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JH68-1", "uniprot_id": "MXA_DANRE", "mass": 73262.0, "length": 646, "protein_name": "Interferon-induced GTP-binding protein MxA", "gene_name": "mxa", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mxa; Mx; fj23d12; wu:fj23d12; zgc:136725", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein MxA; IFN-inducible antiviral protein MxA; Interferon-inducible MxA protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease dominant intermediate B (Disease Ontology:DOID:0110197); centronuclear myopathy 1 (Disease Ontology:DOID:0111223); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); prostate cancer (Disease Ontology:DOID:10283); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); microcytic anemia (Disease Ontology:DOID:11252); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); hereditary spastic paraplegia (Disease Ontology:DOID:2476); liver disease (Disease Ontology:DOID:409); avian influenza (Disease Ontology:DOID:4492); myocardial infarction (Disease Ontology:DOID:5844); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (dre:360142)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12525633;12869211;14698216;16007375;16109975;37833891;38244820;38753517;39217460;39264994;40044042", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0051607 defense response to virus;GO:0009617 response to bacterium;GO:0009615 response to virus;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8JH68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZY6-1", "uniprot_id": "TLK1B_DANRE", "mass": 85454.0, "length": 756, "protein_name": "Serine/threonine-protein kinase tousled-like 1-B", "gene_name": "tlk1b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "tlk1b; fe11e12; si:dkey-251e16.4; tlk1; wu:fe11e12", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase tousled-like 1-B; 2.7.11.1; PKU-beta; Tousled-like kinase 1-B", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:326734)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26235539;27189481", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007059 chromosome segregation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90ZY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHJ2-1", "uniprot_id": "DDX55_DANRE", "mass": 66911.0, "length": 593, "protein_name": "ATP-dependent RNA helicase DDX55", "gene_name": "ddx55", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ddx55; chunp6861; fc32a12; kiaa1595; wu:fc32a12", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX55; 3.6.4.13; DEAD box protein 55", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:286745)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12006978;22412924;26469318;27189481", "class_list": "", "function": "Probable ATP-binding RNA helicase. Plays an essential role in early embryonic development (PubMed:12006978). Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs (By similarity)., [UniProtKB, PubMed, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PBZ0", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0019843 rRNA binding;GO:0003724 RNA helicase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8JHJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUK0-1", "uniprot_id": "RN146_DANRE", "mass": 38786.0, "length": 364, "protein_name": "E3 ubiquitin-protein ligase rnf146", "gene_name": "rnf146", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "rnf146; wu:fi29e08; zgc:55909", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rnf146; 2.3.2.27; RING finger protein 146; RING-type E3 ubiquitin transferase rnf146", "protein_names_refseq": "", "tax_id": 7955, "disease": "osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (dre:334065); (R-DRE-8948751)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16109975;16466575;23594743;26469318;27189481;31053140", "class_list": "", "function": "E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QCU2", "ec_number_list": "2.3.2.27", "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7ZUK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90WY4-1", "uniprot_id": "ADA2A_DANRE", "mass": 43997.0, "length": 388, "protein_name": "Alpha-2A adrenergic receptor", "gene_name": "adra2a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "adra2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR", "protein_names_refseq": "", "tax_id": 7955, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); substance abuse (Disease Ontology:DOID:302); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:266750); (R-DRE-390696); (R-DRE-392023); (R-DRE-400042); (R-DRE-418594); (R-DRE-418597)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "12949138;15655520;15655522;16000146;17941721;24080366;27189481;29145140;32593945;33600148", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15655522). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity). The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine (PubMed:15655522)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0010700 negative regulation of norepinephrine secretion;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q90WY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T321-1", "uniprot_id": "KCMF1_DANRE", "mass": 42048.0, "length": 383, "protein_name": "E3 ubiquitin-protein ligase KCMF1", "gene_name": "kcmf1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase KCMF1", "refseq_ac": "NP_957246", "gene_names_uniprotkb": "kcmf1; si:ch211-220b11.7", "gene_names_refseq": "kcmf1; zgc:64160", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase KCMF1; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase KCMF1; RING-type E3 ubiquitin transferase KCMF1", "tax_id": 7955, "disease": "", "pathway": " (dre:393927); (R-DRE-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15520368;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY394941.1, BC053288.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY394941.1., [RefSeq]; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (By similarity). Together with ubr4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). Together with ubr4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (By similarity). Catalytic component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex that turns off the mitochondrial stress response after a specific stress event has been resolved (By similarity). The SIFI complex ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as dele1 and eif2ak1/hri, as well as (2) unimported mitochondrial precursors such as abhd10 (By similarity). Within the SIFI complex, ubr4 initiates ubiquitin chain that are further elongated or branched by kcmf1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.11;3.6.4.13;2.7.1.40;1.1.1.205;5.4.2.11;5.4.2.4;1.13.11.34;3.2.1.31;3.6.5.-;2.3.2.27;3.6.4.6;4.1.2.13;2.7.11.24;1.11.1.6", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0070534 protein K63-linked ubiquitination;GO:0099536 synaptic signaling;GO:0141191 negative regulation of HRI-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T322-1", "uniprot_id": "NAA35_DANRE", "mass": 83153.0, "length": 724, "protein_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "gene_name": "naa35", "organism": "Zebrafish", "refseq_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "refseq_ac": "NP_955844", "gene_names_uniprotkb": "naa35; egap; mak10", "gene_names_refseq": "mak10; naa35; wu:fb21g10; zgc:64157", "protein_names_uniprotkb": "N-alpha-acetyltransferase 35, NatC auxiliary subunit; Embryonic growth-associated protein; Protein MAK10 homolog; zEGAP", "protein_names_refseq": "EGAP NAT; MAK10 homolog, amino-acid N-acetyltransferase subunit; N-alpha-acetyltransferase 35, NatC auxiliary subunit; embryonic growth-associated protein; protein MAK10 homolog; zEGAP", "tax_id": 7955, "disease": "", "pathway": " (dre:321587)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16484612", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053286.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053286.1. On Jul 6, 2005 this sequence version replaced XP_700722.1., [RefSeq]; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues (By similarity). N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway (By similarity). Regulates cell proliferation during embryonic development (PubMed:16484612)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031417 NatC complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0048514 blood vessel morphogenesis;GO:0001756 somitogenesis;GO:0048659 smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T322-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3C6-1", "uniprot_id": "CPSF5_DANRE", "mass": 26272.0, "length": 228, "protein_name": "Cleavage and polyadenylation specificity factor subunit 5", "gene_name": "nudt21", "organism": "Zebrafish", "refseq_name": "cleavage and polyadenylation specificity factor subunit 5", "refseq_ac": "NP_957411", "gene_names_uniprotkb": "nudt21; cpsf5", "gene_names_refseq": "cpsf5; nudt21; zgc:63966", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 5; Nudix hydrolase 21", "protein_names_refseq": "cleavage and polyadenylation specific factor 5; cleavage and polyadenylation specificity factor subunit 5", "tax_id": 7955, "disease": "", "pathway": " (dre:394092); (R-DRE-73856); (R-DRE-77595); (R-DRE-9770562)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC053172.1, EH442033.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053172.1., [RefSeq]; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005849 mRNA cleavage factor complex;GO:0042382 paraspeckles", "go_biological_process": "GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0010608 post-transcriptional regulation of gene expression;GO:0051290 protein heterotetramerization;GO:2000738 positive regulation of stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T3C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T3S5-1", "uniprot_id": "B3G5A_DANRE", "mass": 43600.0, "length": 379, "protein_name": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A", "gene_name": "b3gnt5a", "organism": "Zebrafish", "refseq_name": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A", "refseq_ac": "NP_942577", "gene_names_uniprotkb": "b3gnt5a; b3gnt5", "gene_names_refseq": "Lc3; b3gnt5a; b3gnt5; fb12f12; wu:fb12f12; wu:fe50g08", "protein_names_uniprotkb": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A; 2.4.1.206; BGnT-5A; Beta-1,3-Gn-T5A; Beta-1,3-N-acetylglucosaminyltransferase 5A; Beta3Gn-T5A; Lactotriaosylceramide synthase A; Lc(3)Cer synthase A; Lc3 synthase A; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A", "protein_names_refseq": "BGnT-5A; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-Gn-T5A; beta-1,3-N-acetylglucosaminyltransferase 5A; beta3Gn-T5A; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A; lactotriaosylceramide synthase A; lc(3)Cer synthase A; lc3 synthase A", "tax_id": 7955, "disease": "", "pathway": " (dre:336526); (R-DRE-913709); (R-DRE-9840309)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14579371;31428591", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY292460.1, CN020622.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY292460.1., [RefSeq]; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids., [UniProtKB, UniProtKB]; Hedgehog signaling is required for the Lc3 synthase expression in embryonic lens, [RefSeq, PubMed]; Together, these results provide new evidence that the Rubicon-dependent Lc3-associated phagocytosis process is an important defense mechanism against Salmonella typhimurium. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.206", "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T3S5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZTS4-1", "uniprot_id": "K1C18_DANRE", "mass": 48631.0, "length": 431, "protein_name": "Keratin, type I cytoskeletal 18", "gene_name": "krt18", "organism": "Zebrafish", "refseq_name": "keratin, type I cytoskeletal 18", "refseq_ac": "NP_848524", "gene_names_uniprotkb": "krt18; dapk1", "gene_names_refseq": "DreK18; cb83; dapk1; krt18a.1; krt18; sb:cb83; wu:fa13f02; wu:fb36b04", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 18; CK-18; Cytokeratin-18; Dorsal aorta proneprin kinesin-1; DreK18; K18; Keratin-18", "protein_names_refseq": "CK-18; K18; cytokeratin-18; dorsal aorta proneprin kinesin-1; keratin 18; keratin, type I cytoskeletal 18", "tax_id": 7955, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary biliary cholangitis (Disease Ontology:DOID:12236); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:352912); (R-DRE-6805567); (R-DRE-6809371)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12558605;18307296;39273043;40044042;9662643", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045869.1, BC164730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045869.1. On Jul 6, 2005 this sequence version replaced XP_702004.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18., [RefSeq, PubMed]; Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of intermediate filaments in simple epithelial cells. Forms obligate heteropolymers with a type II keratin KRT8, mechanical stability and resilience to epithelial cells. When phosphorylated, plays a role in filament reorganization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P042;Q7ZT44", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0001755 neural crest cell migration;GO:0045104 intermediate filament cytoskeleton organization;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7ZTS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU45-1", "uniprot_id": "ODAD4_DANRE", "mass": 55528.0, "length": 486, "protein_name": "Outer dynein arm-docking complex subunit 4", "gene_name": "odad4", "organism": "Zebrafish", "refseq_name": "outer dynein arm-docking complex subunit 4", "refseq_ac": "NP_956610", "gene_names_uniprotkb": "odad4; ttc25; zgc:56362", "gene_names_refseq": "odad4; ttc25; zgc:56362", "protein_names_uniprotkb": "Outer dynein arm-docking complex subunit 4; TPR repeat protein 25; Tetratricopeptide repeat protein 25", "protein_names_refseq": "TPR repeat protein 25; outer dynein arm-docking complex subunit 4; tetratricopeptide repeat domain 25; tetratricopeptide repeat protein 25", "tax_id": 7955, "disease": "primary ciliary dyskinesia 35 (Disease Ontology:DOID:0110620)", "pathway": " (dre:393286)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;25860617", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC051126.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898404, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC051126.1., [RefSeq]; Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and in the docking of ODA in ciliary axoneme., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RBQ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005930 axoneme", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0060271 cilium assembly;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly;GO:0061371 determination of heart left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZU45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU80-1", "uniprot_id": "LNPA_DANRE", "mass": 43841.0, "length": 393, "protein_name": "Endoplasmic reticulum junction formation protein lunapark-A", "gene_name": "lnpka", "organism": "Zebrafish", "refseq_name": "endoplasmic reticulum junction formation protein lunapark-A", "refseq_ac": "NP_955774", "gene_names_uniprotkb": "lnpka; lnpa; lnp; zgc:56261", "gene_names_refseq": "lnpa; lnpka; lnp; lunapark; wu:fe15a04; zgc:56261", "protein_names_uniprotkb": "Endoplasmic reticulum junction formation protein lunapark-A; ER junction formation factor lunapark", "protein_names_refseq": "ER junction formation factor lunapark; endoplasmic reticulum junction formation protein lunapark-A; protein lunapark-A", "tax_id": 7955, "disease": "", "pathway": " (dre:326761)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15520368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050510.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050510.1., [RefSeq]; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6TEM1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network;GO:0098826 endoplasmic reticulum tubular network membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:1903373 positive regulation of endoplasmic reticulum tubular network organization;GO:0071788 endoplasmic reticulum tubular network maintenance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZU80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZU91-1", "uniprot_id": "ITPK1_DANRE", "mass": 44193.0, "length": 396, "protein_name": "Inositol-tetrakisphosphate 1-kinase", "gene_name": "itpk1", "organism": "Zebrafish", "refseq_name": "inositol-tetrakisphosphate 1-kinase", "refseq_ac": "NP_998182", "gene_names_uniprotkb": "itpk1; zgc:56075", "gene_names_refseq": "itpk1a; itpk1; wu:fj15d08; zgc:56075", "protein_names_uniprotkb": "Inositol-tetrakisphosphate 1-kinase; 2.7.1.134; 2.7.1.159; Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase", "protein_names_refseq": "inositol 1,3,4-triphosphate 5/6 kinase; inositol 1,3,4-trisphosphate 5/6-kinase; inositol-tetrakisphosphate 1-kinase; inositol-triphosphate 5/6-kinase; ins(1,3,4)P(3) 5/6-kinase", "tax_id": 7955, "disease": "", "pathway": " (dre:406290)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050497.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC050497.1., [RefSeq]; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RIJ9", "ec_number_list": "2.7.1.134;2.7.1.159", "go_molecular_function": "GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity;GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity;GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity;GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0070266 necroptotic process;GO:0032957 inositol trisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZU91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUC7-1", "uniprot_id": "PGES2_DANRE", "mass": 42792.0, "length": 377, "protein_name": "Prostaglandin E synthase 2", "gene_name": "ptges2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ptges2; pges2; ptgesl", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostaglandin E synthase 2; 5.3.99.3; Microsomal prostaglandin E synthase 2; mPGES-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:799964); (R-DRE-2162123); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate (By similarity). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;1.14.14.1;4.2.1.152;5.3.99.5;2.4.1.1;3.1.27.-;4.6.1.19;3.5.3.1;3.2.1.-;3.2.1.31;5.3.4.1;3.1.6.4;3.5.4.4;5.3.99.3;2.5.1.18;3.1.3.16;1.1.1.205;6.3.4.21;3.6.4.6;1.6.5.5", "go_molecular_function": "GO:0043295 glutathione binding;GO:0020037 heme binding;GO:0016829 lyase activity;GO:0050220 prostaglandin-E synthase activity;GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUG0-1", "uniprot_id": "RUXE_DANRE", "mass": 10789.0, "length": 92, "protein_name": "Small nuclear ribonucleoprotein E", "gene_name": "snrpe", "organism": "Zebrafish", "refseq_name": "small nuclear ribonucleoprotein E", "refseq_ac": "NP_957298", "gene_names_uniprotkb": "snrpe; zgc:56682", "gene_names_refseq": "snrpe; zgc:56682", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein E; Sm protein E; Sm-E; SmE; snRNP-E", "protein_names_refseq": "sm protein E; sm-E; smE; small nuclear ribonucleoprotein E; snRNP-E", "tax_id": 7955, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); hypotrichosis 1 (Disease Ontology:DOID:0110698); hypotrichosis 11 (Disease Ontology:DOID:0110708); prostate cancer (Disease Ontology:DOID:10283); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:393979); (R-DRE-191859); (R-DRE-72163); (R-DRE-72165); (R-DRE-9770562); (R-DRE-9943411)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DT870966.1, BC049062.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1., [RefSeq]; Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0034709 methylosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUM8-1", "uniprot_id": "UBP44_DANRE", "mass": 79926.0, "length": 695, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 44", "gene_name": "usp44", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 44", "refseq_ac": "NP_956551", "gene_names_uniprotkb": "usp44; zgc:55661", "gene_names_refseq": "usp44; zgc:55661", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 44; 3.4.19.12; Deubiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44", "protein_names_refseq": "deubiquitinating enzyme 44; ubiquitin carboxyl-terminal hydrolase 44; ubiquitin thioesterase 44; ubiquitin thiolesterase 44; ubiquitin-specific-processing protease 44", "tax_id": 7955, "disease": "", "pathway": " (dre:393227); (R-DRE-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC048060.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505387, SAMEA3505392 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC048060.1., [RefSeq]; Deubiquitinase that plays a key role in the spindle assembly checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of cdc20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0021551 central nervous system morphogenesis;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZUM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUV2-1", "uniprot_id": "KTNB1_DANRE", "mass": 75995.0, "length": 694, "protein_name": "Katanin p80 WD40 repeat-containing subunit B1", "gene_name": "katnb1", "organism": "Zebrafish", "refseq_name": "katanin p80 WD40 repeat-containing subunit B1", "refseq_ac": "NP_998183", "gene_names_uniprotkb": "katnb1; zgc:56071", "gene_names_refseq": "katnb1; wu:fj32f02; wu:fj65h01; zgc:56071", "protein_names_uniprotkb": "Katanin p80 WD40 repeat-containing subunit B1; Katanin p80 subunit B1; p80 katanin", "protein_names_refseq": "katanin p80 WD40 repeat-containing subunit B1; katanin p80 WD40-containing subunit B1", "tax_id": 7955, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); lissencephaly 6 (Disease Ontology:DOID:0112236); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dre:406291)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25521378;25521379", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505375, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047819.1., [RefSeq]; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0008352 katanin complex;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051013 microtubule severing;GO:0051301 cell division;GO:0007420 brain development;GO:0007019 microtubule depolymerization;GO:0030901 midbrain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZUV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZUY3-1", "uniprot_id": "H2AX_DANRE", "mass": 15001.0, "length": 142, "protein_name": "Histone H2AX", "gene_name": "h2ax", "organism": "Zebrafish", "refseq_name": "histone H2AX", "refseq_ac": "NP_957367", "gene_names_uniprotkb": "h2ax; zgc:56329", "gene_names_refseq": "h2afx; h2ax; zgc:56329", "protein_names_uniprotkb": "Histone H2AX; H2a/x; Histone H2A.X", "protein_names_refseq": "H2A histone family, member X; H2A.X; H2a/x; histone H2A.x; histone H2AX", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); liver benign neoplasm (Disease Ontology:DOID:916); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (dre:394048); (R-DRE-110330); (R-DRE-110331); (R-DRE-201722); (R-DRE-212300); (R-DRE-2299718); (R-DRE-2559580); (R-DRE-2559582); (R-DRE-3214815); (R-DRE-3214858); (R-DRE-427359); (R-DRE-427413); (R-DRE-5250924); (R-DRE-5625886); (R-DRE-5689603); (R-DRE-5689880); (R-DRE-5689901); (R-DRE-68616); (R-DRE-73728); (R-DRE-73772); (R-DRE-8936459); (R-DRE-9018519); (R-DRE-9764725); (R-DRE-9841922); (R-DRE-9843940); (R-DRE-9843970); (R-DRE-9909649); (R-DRE-9940951); (R-DRE-9943411); (R-DRE-9943962)", "pathway_count": 30, "publication_count": 1, "publication_id_list": "36232766", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046078.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046078.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005694 chromosome;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006974 DNA damage response;GO:0051321 meiotic cell cycle;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZUY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV15-1", "uniprot_id": "S22BA_DANRE", "mass": 24390.0, "length": 215, "protein_name": "Vesicle-trafficking protein SEC22b-A", "gene_name": "sec22ba", "organism": "Zebrafish", "refseq_name": "vesicle-trafficking protein SEC22b-A", "refseq_ac": "NP_998549", "gene_names_uniprotkb": "sec22ba; sec22l1a; zgc:56278", "gene_names_refseq": "sec22ba; sec22l1a; sec22l1; wu:fb53h12; wu:fc15g01; zgc:56278", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22b-A; SEC22 vesicle-trafficking protein homolog B-A", "protein_names_refseq": "SEC22 vesicle trafficking protein homolog B, a; SEC22 vesicle-trafficking protein homolog B-A; SEC22, vesicle trafficking protein-like 1A; vesicle-trafficking protein SEC22b-A", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:114464)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046043.1, EH996442.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046043.1., [RefSeq]; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZV15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV50-1", "uniprot_id": "MAGT1_DANRE", "mass": 37422.0, "length": 328, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1", "gene_name": "magt1", "organism": "Zebrafish", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 precursor", "refseq_ac": "NP_955994", "gene_names_uniprotkb": "magt1; zgc:56218", "gene_names_refseq": "fc49b02; magt1; wu:fc49b02; zgc:56218", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; MagT1; Magnesium transporter protein 1; Oligosaccharyl transferase subunit MAGT1", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; magnesium transporter protein 1; oligosaccharyl transferase subunit MAGT1", "tax_id": 7955, "disease": "X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (Disease Ontology:DOID:0080319); congenital disorder of glycosylation Icc (Disease Ontology:DOID:0111839); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (dre:324944); (R-DRE-5223345); (R-DRE-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19717468", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC046002.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505376, SAMEA3505380 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046002.1., [RefSeq]; Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport (PubMed:19717468)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0015693 magnesium ion transport;GO:1903830 magnesium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZV50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV55-1", "uniprot_id": "EIF3I_DANRE", "mass": 36287.0, "length": 325, "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "eif3i", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3 subunit I", "refseq_ac": "NP_998155", "gene_names_uniprotkb": "eif3i; eif3s2", "gene_names_refseq": "eIF3 p36; eif3i; eif3s2; hm:zehn0464; wu:fb62b08; zgc:56211; zgc:77823", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; eIF-3-beta; eIF3 p36; eIF3i", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit I; eukaryotic translation initiation factor 3, subunit 2 beta", "tax_id": 7955, "disease": "", "pathway": " (dre:406263); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "25147179;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045995.1, BC065874.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476749, SAMEA4476803 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045995.1., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]; The translation initiation factor eIF3i up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0001889 liver development;GO:0006413 translational initiation;GO:0002040 sprouting angiogenesis;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZV55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV90-1", "uniprot_id": "PIF1_DANRE", "mass": 71411.0, "length": 639, "protein_name": "ATP-dependent DNA helicase PIF1", "gene_name": "pif1", "organism": "Zebrafish", "refseq_name": "ATP-dependent DNA helicase PIF1", "refseq_ac": "NP_942102", "gene_names_uniprotkb": "pif1; PIF1; cb934; fe11d03; wu:fe11d03; zgc:56161", "gene_names_refseq": "cb934; fe11d03; pif1; wu:fe11d03; zgc:56161", "protein_names_uniprotkb": "ATP-dependent DNA helicase PIF1; 5.6.2.3; DNA 5'-3' helicase PIF1; DNA repair and recombination helicase PIF1", "protein_names_refseq": "ATP-dependent DNA helicase PIF1; DNA 5'-3' helicase PIF1; PIF1 homolog", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); progeria (Disease Ontology:DOID:3911)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045956.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045956.1., [RefSeq]; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043139 5'-3' DNA helicase activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZV90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZV96-1", "uniprot_id": "RL10_DANRE", "mass": 24611.0, "length": 215, "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "rpl10", "organism": "Zebrafish", "refseq_name": "large ribosomal subunit protein uL16", "refseq_ac": "NP_956321", "gene_names_uniprotkb": "rpl10; QM protein; QM; fa93d03; rpl-10; wu:fa93d03; zgc:56154", "gene_names_refseq": "QM protein; QM; fa93d03; rpl-10; rpl10; wu:fa93d03; zgc:56154", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16; 60S ribosomal protein L10; Protein QM; Ribosomal protein L10", "protein_names_refseq": "60S ribosomal protein L10; associated with tumor suppression, cell growth, differentiation, development and apoptosis; large ribosomal subunit protein uL16; protein QM", "tax_id": 7955, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); syndromic X-linked mental retardation 35 (Disease Ontology:DOID:0080241); spermatogenic failure 63 (Disease Ontology:DOID:0112356); autistic disorder (Disease Ontology:DOID:12849); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72689); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954709); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "23594743;25316788;31792295;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045950.1, CN322641.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505384, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045950.1., [RefSeq]; Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the large ribosomal subunit (Probable). Plays a role in the formation of actively translating ribosomes (PubMed:25316788). Plays a role in the embryonic brain development (PubMed:25316788)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0007420 brain development;GO:0006412 translation;GO:1990403 embryonic brain development;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7ZV96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVC4-1", "uniprot_id": "CHM4B_DANRE", "mass": 24796.0, "length": 220, "protein_name": "Charged multivesicular body protein 4b", "gene_name": "chmp4b", "organism": "Zebrafish", "refseq_name": "charged multivesicular body protein 4b", "refseq_ac": "NP_956489", "gene_names_uniprotkb": "chmp4b; zgc:56112", "gene_names_refseq": "chmp4ba; zgc:56112", "protein_names_uniprotkb": "Charged multivesicular body protein 4b; CHMP4b; Chromatin-modifying protein 4b", "protein_names_refseq": "CHMP4b; charged multivesicular body protein 4b; chromatin-modifying protein 4b", "tax_id": 7955, "disease": "cataract 31 multiple types (Disease Ontology:DOID:0110265)", "pathway": " (dre:393164); (R-DRE-1632852); (R-DRE-917729); (R-DRE-9668328)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "37487085", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045919.1, EH436010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045919.1., [RefSeq]; HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53., [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0010458 exit from mitosis;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZVC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVE6-1", "uniprot_id": "PLGT2_DANRE", "mass": 57802.0, "length": 500, "protein_name": "Protein O-glucosyltransferase 2", "gene_name": "poglut2", "organism": "Zebrafish", "refseq_name": "protein O-glucosyltransferase 2 precursor", "refseq_ac": "NP_957225", "gene_names_uniprotkb": "poglut2; kdelc1; si:dkey-22a1.1; zgc:56065", "gene_names_refseq": "Kdel1; kdelc1; poglut2; zgc:56065", "protein_names_uniprotkb": "Protein O-glucosyltransferase 2; 2.4.1.-; 2.4.2.-; KDEL motif-containing protein 1; Protein O-xylosyltransferase POGLUT2", "protein_names_refseq": "KDEL (Lys-Asp-Glu-Leu) containing 1; KDEL motif-containing protein 1; protein O-glucosyltransferase 2 precursor; protein O-xylosyltransferase POGLUT2", "tax_id": 7955, "disease": "", "pathway": " (dre:393905)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18296487;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045893.1, CU638807.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045893.1., [RefSeq]; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B0CM11;Q5RI39", "ec_number_list": "2.4.2.-;2.4.1.-", "go_molecular_function": "GO:0046527 glucosyltransferase activity;GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0140561 EGF-domain serine glucosyltransferase activity;GO:0140562 EGF-domain serine xylosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system", "go_biological_process": "GO:0007399 nervous system development;GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZVE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVF3-1", "uniprot_id": "SDHA_DANRE", "mass": 72078.0, "length": 661, "protein_name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "gene_name": "sdha", "organism": "Zebrafish", "refseq_name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor", "refseq_ac": "NP_957204", "gene_names_uniprotkb": "sdha; im:7141001; si:dkeyp-84f11.2; zgc:56051", "gene_names_refseq": "im:7141001; sdha; zgc:56051", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Flavoprotein subunit of complex II; Fp; Malate dehydrogenase [quinone] flavoprotein subunit", "protein_names_refseq": "flavoprotein subunit of complex II; fp; malate dehydrogenase [quinone] flavoprotein subunit; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 5 (Disease Ontology:DOID:0061220); dilated cardiomyopathy 1GG (Disease Ontology:DOID:0110435); leukodystrophy (Disease Ontology:DOID:10579); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); Leigh disease (Disease Ontology:DOID:3652); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (dre:393884); (R-DRE-71403); (R-DRE-9854311)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045885.1, BC164560.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045885.1. On Jul 6, 2005 this sequence version replaced XP_702394.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LV99", "ec_number_list": "1.3.5.1;1.1.5.-", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0008177 succinate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7ZVF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVF9-1", "uniprot_id": "ACTB2_DANRE", "mass": 41753.0, "length": 375, "protein_name": "Actin, cytoplasmic 2", "gene_name": "actbb", "organism": "Zebrafish", "refseq_name": "actin, cytoplasmic 2", "refseq_ac": "NP_853632", "gene_names_uniprotkb": "actbb; bactin2", "gene_names_refseq": "actb2; actbb; bact2; bactin2", "protein_names_uniprotkb": "Actin, cytoplasmic 2; 3.6.4.-; Beta-actin-2", "protein_names_refseq": "actin, cytoplasmic 2; beta-actin-2", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Baraitser-Winter syndrome 2 (Disease Ontology:DOID:0081113); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hand, foot and mouth disease (Disease Ontology:DOID:10881); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dre:57935); (R-DRE-114608); (R-DRE-196025); (R-DRE-2029482); (R-DRE-3928662); (R-DRE-418990); (R-DRE-4420097); (R-DRE-446353); (R-DRE-5626467); (R-DRE-5663213); (R-DRE-5663220); (R-DRE-5674135); (R-DRE-5689603); (R-DRE-5696394); (R-DRE-9035034); (R-DRE-9764561); (R-DRE-9933947); (R-DRE-9953170); (R-DRE-9958825)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "30626964;9551184", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: BC154531.1, GDQH01000046.1 [ECO:0000331] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Feb 12, 2013 this sequence version replaced NP_853632.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O73815;P12714;Q6NWJ6", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.11.1;3.6.5.2;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;2.7.10.1;3.1.27.-;5.6.2.-;2.3.2.31;2.7.7.7;2.7.7.49;5.6.2.5;2.3.2.26;1.8.-.-;1.15.1.1;2.7.10.2;3.6.5.-;3.4.-.-;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZVF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVI7-1", "uniprot_id": "ACTB1_DANRE", "mass": 41767.0, "length": 375, "protein_name": "Actin, cytoplasmic 1", "gene_name": "actba", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "actba; bactin1; bactzf; bact", "gene_names_refseq": "", "protein_names_uniprotkb": "Actin, cytoplasmic 1; 3.6.4.-; Beta-actin-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Baraitser-Winter syndrome 2 (Disease Ontology:DOID:0081113); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hand, foot and mouth disease (Disease Ontology:DOID:10881); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dre:57934); (R-DRE-114608); (R-DRE-196025); (R-DRE-2029482); (R-DRE-3928662); (R-DRE-418990); (R-DRE-4420097); (R-DRE-446353); (R-DRE-5626467); (R-DRE-5663213); (R-DRE-5663220); (R-DRE-5674135); (R-DRE-5689603); (R-DRE-5696394); (R-DRE-9035034); (R-DRE-9764561); (R-DRE-9933947); (R-DRE-9953170); (R-DRE-9958825)", "pathway_count": 19, "publication_count": 3, "publication_id_list": "30626964;40044042;9987040", "class_list": "", "function": "Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O73815;P12714;Q6P3K9", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.11.1;3.6.5.2;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;2.7.10.1;3.1.27.-;5.6.2.-;2.3.2.31;2.7.7.7;2.7.7.49;5.6.2.5;2.3.2.26;1.8.-.-;1.15.1.1;2.7.10.2;3.6.5.-;3.4.-.-;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7ZVI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVM1-1", "uniprot_id": "WASC5_DANRE", "mass": 133599.0, "length": 1159, "protein_name": "WASH complex subunit 5", "gene_name": "washc5", "organism": "Zebrafish", "refseq_name": "WASH complex subunit 5", "refseq_ac": "NP_956477", "gene_names_uniprotkb": "washc5; zgc:55908", "gene_names_refseq": "strumpellin; washc5; zgc:55908", "protein_names_uniprotkb": "WASH complex subunit 5; WASH complex subunit strumpellin", "protein_names_refseq": "WASH complex subunit 5; WASH complex subunit strumpellin; spastic paraplegia 8", "tax_id": 7955, "disease": "Ritscher-Schinzel syndrome 1 (Disease Ontology:DOID:0060571); hereditary spastic paraplegia 8 (Disease Ontology:DOID:0110823)", "pathway": " (dre:393152)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24065355", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045490.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045490.1. On Jul 6, 2005 this sequence version replaced XP_702246.1., [RefSeq]; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0071203 WASH complex", "go_biological_process": "GO:0051125 regulation of actin nucleation;GO:0007409 axonogenesis;GO:0015031 protein transport;GO:0060047 heart contraction;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZVM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVS9-1", "uniprot_id": "MYCB_DANRE", "mass": 44919.0, "length": 396, "protein_name": "Transcriptional regulator Myc-B", "gene_name": "mycb", "organism": "Zebrafish", "refseq_name": "transcriptional regulator Myc-B", "refseq_ac": "NP_956466", "gene_names_uniprotkb": "mycb; zgc:55680", "gene_names_refseq": "mycb; zgc:55680", "protein_names_uniprotkb": "Transcriptional regulator Myc-B; c-Myc-B", "protein_names_refseq": "C-Myc2; c-Myc-B; cmycb; myelocytomatosis oncogene b; transcriptional regulator Myc-B; v-myc avian myelocytomatosis viral oncogene homolog b", "tax_id": 7955, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); leiomyoma (Disease Ontology:DOID:127); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); hyperparathyroidism (Disease Ontology:DOID:13543); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); demyelinating disease (Disease Ontology:DOID:3213); rhabdoid cancer (Disease Ontology:DOID:3672); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pancreatic carcinoma (Disease Ontology:DOID:4905); liver cirrhosis (Disease Ontology:DOID:5082); prolactinoma (Disease Ontology:DOID:5394); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:393141)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38984586", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045424.1, EH546656.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045424.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mycb and Mych stimulate Muller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina., [RefSeq, PubMed]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7ZVS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZVV1-1", "uniprot_id": "ERCC3_DANRE", "mass": 89288.0, "length": 782, "protein_name": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB", "gene_name": "ercc3", "organism": "Zebrafish", "refseq_name": "general transcription and DNA repair factor IIH helicase/translocase subunit XPB", "refseq_ac": "NP_963876", "gene_names_uniprotkb": "ercc3", "gene_names_refseq": "ercc3; wu:fc25f08", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB; 5.6.2.4; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; TFIIH subunit XPB", "protein_names_refseq": "DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; excision repair cross-complementing rodent repair deficiency, complementation group 3; general transcription and DNA repair factor IIH helicase subunit XPB; general transcription and DNA repair factor IIH helicase/translocase subunit XPB; xpb", "tax_id": 7955, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group B (Disease Ontology:DOID:0110850); trichothiodystrophy (Disease Ontology:DOID:0111866); photosensitive trichothiodystrophy 2 (Disease Ontology:DOID:0111869); Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); Down syndrome (Disease Ontology:DOID:14250); Cockayne syndrome (Disease Ontology:DOID:2962); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:324323); (R-DRE-113418); (R-DRE-5696395); (R-DRE-5696400); (R-DRE-674695); (R-DRE-6781823); (R-DRE-6782135); (R-DRE-6782210); (R-DRE-6796648); (R-DRE-72086); (R-DRE-73772); (R-DRE-73776); (R-DRE-73779); (R-DRE-73863); (R-DRE-75953); (R-DRE-75955); (R-DRE-76042); (R-DRE-77075)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045400.1, BC165665.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045400.1., [RefSeq]; ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting and twisting that allows XPD/ERCC2 helicase to anchor. The ATP-dependent helicase activity of XPB/ERCC3 may be required for promoter escape. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.7.6;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;6.5.1.1;2.7.7.7;5.6.2.-;2.7.7.49;2.7.11.22;2.7.11.23;5.6.2.5;2.1.1.56;3.6.5.-;2.4.2.-;2.4.2.30;3.4.-.-;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005675 transcription factor TFIIH holo complex;GO:0000112 nucleotide-excision repair factor 3 complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006283 transcription-coupled nucleotide-excision repair;GO:0006265 DNA topological change", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZVV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZW02-1", "uniprot_id": "CHPT1_DANRE", "mass": 42463.0, "length": 382, "protein_name": "Cholinephosphotransferase 1", "gene_name": "chpt1", "organism": "Zebrafish", "refseq_name": "cholinephosphotransferase 1", "refseq_ac": "NP_997789", "gene_names_uniprotkb": "chpt1", "gene_names_refseq": "chpt1; fd50f07; sycp3; wu:fb67a04; wu:fd50f07", "protein_names_uniprotkb": "Cholinephosphotransferase 1; 2.7.8.2; Diacylglycerol cholinephosphotransferase 1", "protein_names_refseq": "cholinephosphotransferase 1; diacylglycerol cholinephosphotransferase 1; synaptonemal complex protein 3", "tax_id": 7955, "disease": "retinal disease (Disease Ontology:DOID:5679)", "pathway": " (dre:322605); (R-DRE-1483191)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21402175;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045345.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505381 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045345.1., [RefSeq]; Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes., [UniProtKB, UniProtKB]; Immunohistochemical observations revealed that Sycp3 is specifically localized in spermatocytes in typical nuclear patterns at each meiotic stage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.8.2;2.7.8.1;2.7.8.22", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7ZW02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZWG6-1", "uniprot_id": "PCFT_DANRE", "mass": 52188.0, "length": 481, "protein_name": "Proton-coupled folate transporter", "gene_name": "slc46a1", "organism": "Zebrafish", "refseq_name": "proton-coupled folate transporter", "refseq_ac": "NP_956579", "gene_names_uniprotkb": "slc46a1; pcft; zgc:56400", "gene_names_refseq": "slc46a1; zgc:56400", "protein_names_uniprotkb": "Proton-coupled folate transporter; Solute carrier family 46 member 1", "protein_names_refseq": "PCFT/HCP1; heme carrier protein 1; proton-coupled folate transporter; solute carrier family 46 (folate transporter), member 1", "tax_id": 7955, "disease": "hereditary folate malabsorption (Disease Ontology:DOID:0111678); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dre:393255); (R-DRE-196757); (R-DRE-917937); (R-DRE-9707616)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505381, SAMEA3505383 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049421.1., [RefSeq]; Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (By similarity). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (By similarity). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015350 methotrexate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity;GO:0005542 folic acid binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZWG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZYW0-1", "uniprot_id": "Q7ZYW0_DANRE", "mass": 40163.0, "length": 349, "protein_name": "1.17.4.1; Ribonucleoside-diphosphate reductase subunit M2 B", "gene_name": "rrm2b", "organism": "Zebrafish", "refseq_name": "ribonucleoside-diphosphate reductase subunit M2 B", "refseq_ac": "NP_001007164", "gene_names_uniprotkb": "rrm2b; fb72h01; fb93b05; rrm2; si:zc215i13.5; wu:fb72h01; wu:fb93b05", "gene_names_refseq": "fb72h01; fb93b05; rrm2b; rrm2; si:zc215i13.5; wu:fb72h01; wu:fb93b05", "protein_names_uniprotkb": "1.17.4.1; Ribonucleoside-diphosphate reductase subunit M2 B", "protein_names_refseq": "ribonucleoside-diphosphate reductase subunit M2 B", "tax_id": 7955, "disease": "mitochondrial DNA depletion syndrome 8a (Disease Ontology:DOID:0080127); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518)", "pathway": " (dre:368909); (R-DRE-499943)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19159490;21194559;21887375;24989799;26011545;27402763;29751158;32931159", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC108037.1, SRR26395013.148811.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On Jun 25, 2025 this sequence version replaced NP_001007164.1., [RefSeq]; Functions of p53R2 in zebrafish are closely associated with its activity in DNA repair and synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N311", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006974 DNA damage response;GO:0007005 mitochondrion organization;GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7ZYW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZZ04-1", "uniprot_id": "Q7ZZ04_DANRE", "mass": 31252.0, "length": 291, "protein_name": "Enoyl-CoA hydratase, mitochondrial", "gene_name": "echs1", "organism": "Zebrafish", "refseq_name": "enoyl-CoA hydratase, mitochondrial", "refseq_ac": "NP_001004529", "gene_names_uniprotkb": "echs1; fj55e05; si:zc217g15.1; wu:fj55e05", "gene_names_refseq": "echs1; fj55e05; si:zc217g15.1; wu:fj55e05", "protein_names_uniprotkb": "Enoyl-CoA hydratase, mitochondrial; 4.2.1.17; 5.3.3.8; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase", "protein_names_refseq": "enoyl Coenzyme A hydratase, short chain, 1, mitochondrial; enoyl-CoA hydratase, mitochondrial", "tax_id": 7955, "disease": "mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (Disease Ontology:DOID:0070540)", "pathway": " (dre:368912); (R-DRE-70895); (R-DRE-77310); (R-DRE-77346); (R-DRE-77348); (R-DRE-77350); (R-DRE-77352)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "16872691;19127516;20528263;21481936;23744565;32332781;32612127;32648304;34016526;37650211", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01009137.1, GDQH01002282.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000013.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1N1U5", "ec_number_list": "5.3.3.8;1.1.1.35;4.2.1.17", "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7ZZ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q801F7-1", "uniprot_id": "WN10B_DANRE", "mass": 47407.0, "length": 427, "protein_name": "Protein Wnt-10b", "gene_name": "wnt10b", "organism": "Zebrafish", "refseq_name": "protein Wnt-10b precursor", "refseq_ac": "NP_835737", "gene_names_uniprotkb": "wnt10b; Zwnt[d]; wnt10br; wnt[d]", "gene_names_refseq": "Zwnt[d]; wnt10br; wnt10b; wnt[d]", "protein_names_uniprotkb": "Protein Wnt-10b", "protein_names_refseq": "protein Wnt-10b precursor; protein Wnt-10b; wnt-d; wnt10b-related", "tax_id": 7955, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); split hand-foot malformation 6 (Disease Ontology:DOID:0090026); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30308); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12591239;15147762;15366005", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY182171.1, BC162831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476760, SAMEA4476784 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY182171.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; In zebrafish embryos lacking Wnt3a, Wnt1 and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 is not maintained after mid-somitogenesis, [RefSeq, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030182 neuron differentiation;GO:0060070 canonical Wnt signaling pathway;GO:0030917 midbrain-hindbrain boundary development;GO:0045165 cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q801F7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802G6-1", "uniprot_id": "MSB1A_DANRE", "mass": 12553.0, "length": 110, "protein_name": "Methionine-R-sulfoxide reductase B1-A", "gene_name": "msrb1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "msrb1; sepx1a; sepx1", "gene_names_refseq": "", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B1-A; 1.8.4.12; 1.8.4.14; MsrB1-A; MsrB; SePR; SelX-A; Selenoprotein X-A", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:352916); (R-DRE-5676934)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12915322", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (mical1, mical2 or mical3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NWX6", "ec_number_list": "1.8.4.14;1.8.4.12", "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045087 innate immune response;GO:0030041 actin filament polymerization;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q802G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q802X2-1", "uniprot_id": "NCOA4_DANRE", "mass": 65243.0, "length": 576, "protein_name": "Nuclear receptor coactivator 4", "gene_name": "ncoa4", "organism": "Zebrafish", "refseq_name": "nuclear receptor coactivator 4", "refseq_ac": "NP_957423", "gene_names_uniprotkb": "ncoa4; zgc:55307; zgc:77270", "gene_names_refseq": "NCoA-4; ncoa4; zgc:55307; zgc:77270", "protein_names_uniprotkb": "Nuclear receptor coactivator 4; Ferritin cargo receptor NCOA4; NCoA-4", "protein_names_refseq": "ferritin cargo receptor NCOA4; nuclear receptor coactivator 4", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); polycystic ovary syndrome (Disease Ontology:DOID:11612); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (dre:394104)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;26436293;29027256", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC047166.1, BC065638.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC047166.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cargo receptor for the autophagic turnover of ferritin (By similarity). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (By similarity). Plays a role in erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). Binds chromatin before initiation of DNA replication and detaches during replication (By similarity). Inhibits activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B394;Q6P0F7", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0005694 chromosome;GO:0044754 autolysosome", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q802X2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803A7-1", "uniprot_id": "SPCS_DANRE", "mass": 53730.0, "length": 490, "protein_name": "O-phosphoseryl-tRNA(Sec) selenium transferase", "gene_name": "sepsecs", "organism": "Zebrafish", "refseq_name": "O-phosphoseryl-tRNA(Sec) selenium transferase", "refseq_ac": "NP_956448", "gene_names_uniprotkb": "sepsecs; lpl; zgc:55980", "gene_names_refseq": "sepsecs; sla/lpl; zgc:55980", "protein_names_uniprotkb": "O-phosphoseryl-tRNA(Sec) selenium transferase; 2.9.1.2; Sec synthase; Selenocysteine synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen/liver pancreas antigen-like; UGA suppressor tRNA-associated protein homolog", "protein_names_refseq": "O-phosphoseryl-tRNA(Sec) selenium transferase; UGA suppressor tRNA-associated protein homolog; sec synthase; selenocysteine synthase; selenocysteinyl-tRNA(Sec) synthase; sep-tRNA:Sec-tRNA synthase; soluble liver antigen/liver pancreas antigen, like", "tax_id": 7955, "disease": "pontocerebellar hypoplasia type 2D (Disease Ontology:DOID:0060270)", "pathway": " (dre:393123)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044561.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044561.1. On Jul 6, 2005 this sequence version replaced XP_702227.1., [RefSeq]; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.9.1.2", "go_molecular_function": "GO:0000049 tRNA binding;GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001514 selenocysteine incorporation;GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q803A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q803F6-1", "uniprot_id": "RSSA_DANRE", "mass": 34012.0, "length": 308, "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "rpsa", "organism": "Zebrafish", "refseq_name": "small ribosomal subunit protein uS2", "refseq_ac": "NP_957346", "gene_names_uniprotkb": "rpsa; lamr1", "gene_names_refseq": "lamr1; rpsa; zgc:55831; zgc:77824", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; LamR; Laminin receptor 1; Laminin-binding protein precursor p40", "protein_names_refseq": "laminin receptor 1 (ribosomal protein SA); small ribosomal subunit protein uS2", "tax_id": 7955, "disease": "arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); sciatic neuropathy (Disease Ontology:DOID:11446); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (dre:394027); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "15520368;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC044504.1, EH489117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC044504.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043236 laminin binding;GO:0005055 laminin receptor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q803F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q805B2-1", "uniprot_id": "FGF8B_DANRE", "mass": 24975.0, "length": 212, "protein_name": "Fibroblast growth factor 8b", "gene_name": "fgf8b", "organism": "Zebrafish", "refseq_name": "fibroblast growth factor 8b precursor", "refseq_ac": "NP_878276", "gene_names_uniprotkb": "fgf8b; fgf17a; fgf17", "gene_names_refseq": "fgf17a; fgf17; fgf8b", "protein_names_uniprotkb": "Fibroblast growth factor 8b; FGF-17a; FGF-8b; Fibroblast growth factor 17a", "protein_names_refseq": "FGF-17a; FGF-8b; fibroblast growth factor 17 a; fibroblast growth factor 17a; fibroblast growth factor 8 b; fibroblast growth factor 8b precursor", "tax_id": 7955, "disease": "hypogonadotropic hypogonadism 6 with or without anosmia (Disease Ontology:DOID:0090086); hypospadias (Disease Ontology:DOID:10892); prostatic hypertrophy (Disease Ontology:DOID:11132); DiGeorge syndrome (Disease Ontology:DOID:11198); breast cancer (Disease Ontology:DOID:1612); endodermal sinus tumor (Disease Ontology:DOID:1911); embryonal carcinoma (Disease Ontology:DOID:3308); choriocarcinoma (Disease Ontology:DOID:3594); tetralogy of Fallot (Disease Ontology:DOID:6419); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dre:65089)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11091072", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB100171.1, BC163345.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505382, SAMEA3505386 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB100171.1. On Jul 6, 2005 this sequence version replaced XP_693810.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q805B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AXZ4-1", "uniprot_id": "CNT1A_DANRE", "mass": 114335.0, "length": 1032, "protein_name": "Contactin-1a", "gene_name": "cntn1a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "cntn1a; cntn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Contactin-1a; F3/F11/contactin; Neural cell recognition molecule F11", "protein_names_refseq": "", "tax_id": 7955, "disease": "Compton-North congenital myopathy (Disease Ontology:DOID:0080101)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "14516675", "class_list": "", "function": "Mediates cell surface interactions during nervous system development., [UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0098552 side of membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AXZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AYM7-1", "uniprot_id": "OPSG3_DANRE", "mass": 38882.0, "length": 349, "protein_name": "Green-sensitive opsin-3", "gene_name": "opn1mw3", "organism": "Zebrafish", "refseq_name": "green-sensitive opsin-3", "refseq_ac": "NP_878312", "gene_names_uniprotkb": "opn1mw3; rh23; si:zc263a23.3", "gene_names_refseq": "RH2-3; grops2; opn1mw3; rh2.3; si:zc263a23.3", "protein_names_uniprotkb": "Green-sensitive opsin-3; Green cone photoreceptor pigment 3; Opsin RH2-3; Opsin-1, medium-wave-sensitive 3", "protein_names_refseq": "green cone photoreceptor pigment 3; green-sensitive opsin-3; green-sensitive opsin; opsin RH2-3; opsin-1, medium-wave-sensitive 3; rhodopsin-like-2.3 cone opsin", "tax_id": 7955, "disease": "", "pathway": " (dre:360152)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12618404;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC075989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC075989.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to medium-wavelength (green) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8AYM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AYM8-1", "uniprot_id": "OPSG2_DANRE", "mass": 38706.0, "length": 349, "protein_name": "Green-sensitive opsin-2", "gene_name": "opn1mw2", "organism": "Zebrafish", "refseq_name": "green-sensitive opsin-2", "refseq_ac": "NP_878311", "gene_names_uniprotkb": "opn1mw2; rh22", "gene_names_refseq": "RH2-2; grops1; grops2; opn1mw2; rh2.2; si:zc263a23.4; wu:fk57c11", "protein_names_uniprotkb": "Green-sensitive opsin-2; Green cone photoreceptor pigment 2; Opsin RH2-2; Opsin-1, medium-wave-sensitive 2", "protein_names_refseq": "green cone photoreceptor pigment 2; green-sensitive opsin-2; green-sensitive opsin; opsin RH2-2; opsin-1, medium-wave-sensitive 2; rhodopsin-like-2.2 cone opsin", "tax_id": 7955, "disease": "", "pathway": " (dre:360151)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12618404", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055605.1, BC164163.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055605.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to medium-wavelength (green) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AYM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AYN0-1", "uniprot_id": "OPSR2_DANRE", "mass": 39518.0, "length": 356, "protein_name": "Red-sensitive opsin-2", "gene_name": "opn1lw2", "organism": "Zebrafish", "refseq_name": "red-sensitive opsin-2", "refseq_ac": "NP_001002443", "gene_names_uniprotkb": "opn1lw2; lws2; zgc:92632", "gene_names_refseq": "lws2up; lws2; opn1lw2; zgc:92632", "protein_names_uniprotkb": "Red-sensitive opsin-2; Opsin LWS-2; Opsin-1, long-wave-sensitive 2; Red cone photoreceptor pigment 2", "protein_names_refseq": "long-wavelength-sensitive-2 cone opsin; opsin LWS-2; opsin-1, long-wave-sensitive 2; red cone photoreceptor pigment 2; red-sensitive opsin-2", "tax_id": 7955, "disease": "blue cone monochromacy (Disease Ontology:DOID:0050679); red-green color blindness (Disease Ontology:DOID:13909); red color blindness (Disease Ontology:DOID:13910)", "pathway": " (dre:436716); (R-DRE-2187335); (R-DRE-418594); (R-DRE-419771)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12618404;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076120.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076120.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to long-wavelength (red) light, thereby decreasing intracellular cAMP levels (PubMed:12618404). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6DH62", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8AYN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JFD6-1", "uniprot_id": "Q8JFD6_DANRE", "mass": 35060.0, "length": 304, "protein_name": "Gap junction protein", "gene_name": "gjd2b", "organism": "Zebrafish", "refseq_name": "gap junction protein delta 2b", "refseq_ac": "NP_919401", "gene_names_uniprotkb": "gjd2b; connexin35; cx35b; cx35; gja9", "gene_names_refseq": "connexin35; cx35b; cx35; gja9; gjd2b", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "connexin 35b; connexin 35; cx35.1; gap junction protein alpha 9; gap junction protein delta 2b", "tax_id": 7955, "disease": "", "pathway": " (dre:378444); (R-DRE-112303)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12949901;14648847;15282192;16337772;17338632;35325106;36936688;38129658;38270285;39067805", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF462040.1, BC162925.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF462040.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The gamma hemichannel of Cx35 hemichannels exhibited a pronounced membrane potential dependence, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8RRX4;F6NIU1", "ec_number_list": "", "go_molecular_function": "GO:0005244 voltage-gated monoatomic ion channel activity;GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007416 synapse assembly;GO:1903859 regulation of dendrite extension", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8JFD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JG69-1", "uniprot_id": "AA2DB_DANRE", "mass": 46863.0, "length": 415, "protein_name": "Alpha-2Db adrenergic receptor", "gene_name": "adra2db", "organism": "Zebrafish", "refseq_name": "alpha-2Db adrenergic receptor", "refseq_ac": "NP_919346", "gene_names_uniprotkb": "adra2db", "gene_names_refseq": "adra2db; zgc:194662", "protein_names_uniprotkb": "Alpha-2Db adrenergic receptor; Alpha(2Db)AR; Alpha-2Db adrenoceptor; Alpha-2Db adrenoreceptor", "protein_names_refseq": "alpha(2Db)AR; alpha-2Db adrenergic receptor; alpha-2Db adrenoceptor; alpha-2Db adrenoreceptor", "tax_id": 7955, "disease": "", "pathway": " (dre:266755)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12949138;15655522", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC163314.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY120896.1., [RefSeq]; Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine = epinephrine > oxymetazoline., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0019229 regulation of vasoconstriction;GO:0030168 platelet activation;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JG69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JG70-1", "uniprot_id": "AA2DA_DANRE", "mass": 46199.0, "length": 408, "protein_name": "Alpha-2Da adrenergic receptor", "gene_name": "adra2da", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "adra2da", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-2Da adrenergic receptor; Alpha(2Da)AR; Alpha-2Da adrenoceptor; Alpha-2Da adrenoreceptor", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12949138;15655522", "class_list": "", "function": "Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine > oxymetazoline., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JG70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JGR6-1", "uniprot_id": "NCBP2_DANRE", "mass": 17932.0, "length": 155, "protein_name": "Nuclear cap-binding protein subunit 2", "gene_name": "ncbp2", "organism": "Zebrafish", "refseq_name": "nuclear cap-binding protein subunit 2", "refseq_ac": "NP_775356", "gene_names_uniprotkb": "ncbp2; cbp20; ch211-258l4.5", "gene_names_refseq": "CHUNP6917; ncbp2; zgc:92592", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 2; 20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit", "protein_names_refseq": "20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit; nuclear cap binding protein subunit 2, 20kD; nuclear cap-binding protein subunit 2", "tax_id": 7955, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (dre:192325); (R-DRE-113418); (R-DRE-159236); (R-DRE-674695); (R-DRE-6803529); (R-DRE-6807505); (R-DRE-72163); (R-DRE-72165); (R-DRE-72203); (R-DRE-73856); (R-DRE-77595); (R-DRE-975956); (R-DRE-975957); (R-DRE-9770562); (R-DRE-9930044)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "12006978;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY099530.1, EH497250.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505374, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY099530.1., [RefSeq]; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1MT38;Q5XIY9", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0017069 snRNA binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005846 nuclear cap binding complex", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0006417 regulation of translation;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JGR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JGS0-1", "uniprot_id": "RU1C_DANRE", "mass": 17286.0, "length": 159, "protein_name": "U1 small nuclear ribonucleoprotein C", "gene_name": "snrpc", "organism": "Zebrafish", "refseq_name": "U1 small nuclear ribonucleoprotein C", "refseq_ac": "NP_775358", "gene_names_uniprotkb": "snrpc", "gene_names_refseq": "U1-C; U1C; chunp6909; snrpc; zgc:109792", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C; U1C", "protein_names_refseq": "U1 small nuclear ribonucleoprotein C", "tax_id": 7955, "disease": "mixed connective tissue disease (Disease Ontology:DOID:3492); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dre:192330); (R-DRE-9770562)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12006978;21468032;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC091442.1, CO250216.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091442.1., [RefSeq]; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030627 pre-mRNA 5'-splice site binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JGS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JGW0-1", "uniprot_id": "TSP4B_DANRE", "mass": 103991.0, "length": 949, "protein_name": "Thrombospondin-4-B", "gene_name": "thbs4b", "organism": "Zebrafish", "refseq_name": "thrombospondin-4-B precursor", "refseq_ac": "NP_775333", "gene_names_uniprotkb": "thbs4b; thbs4; tsp4; zgc:111910", "gene_names_refseq": "thbs4b; thbs4; tsp4; zgc:111910", "protein_names_uniprotkb": "Thrombospondin-4-B; Thbs4-B", "protein_names_refseq": "Tsp-4a; thbs4-B; thrombospondin 4; thrombospondin-4-B precursor; thrombospondin-4-B; tsp4b", "tax_id": 7955, "disease": "", "pathway": " (dre:252850); (R-DRE-186797)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12592708;24941943;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY081009.1, BC095593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY081009.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response (By similarity)., [UniProtKB]; Tsp4 functions as an ECM scaffold at myotendinous junctions, with potential therapeutic uses in tendon strengthening and repair Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0007155 cell adhesion;GO:0051781 positive regulation of cell division;GO:0006986 response to unfolded protein;GO:0035989 tendon development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8JGW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHF0-1", "uniprot_id": "PEN2_DANRE", "mass": 11851.0, "length": 101, "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "psenen", "organism": "Zebrafish", "refseq_name": "gamma-secretase subunit PEN-2", "refseq_ac": "NP_991139", "gene_names_uniprotkb": "psenen; pen2; zgc:109727", "gene_names_refseq": "pen-2; pen2; psenen; zgc:109727", "protein_names_uniprotkb": "Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2 homolog", "protein_names_refseq": "gamma-secretase subunit PEN-2; presenilin enhancer 2 homolog; presenilin enhancer protein 2 homolog", "tax_id": 7955, "disease": "hidradenitis suppurativa (Disease Ontology:DOID:2280)", "pathway": " (dre:402810); (R-DRE-1251985); (R-DRE-193692); (R-DRE-3928665); (R-DRE-9839383)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "12110170;25814654", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF512427.1, EH450174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF512427.1., [RefSeq]; Both human PS2V and zebrafish PS1IV can stimulate gamma-secretase activity despite extreme structural divergence., [RefSeq, PubMed]; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q568W9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane;GO:0070765 gamma-secretase complex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0043066 negative regulation of apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0042982 amyloid precursor protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JHF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHJ1-1", "uniprot_id": "RL35_DANRE", "mass": 14430.0, "length": 123, "protein_name": "Large ribosomal subunit protein uL29", "gene_name": "rpl35", "organism": "Zebrafish", "refseq_name": "large ribosomal subunit protein uL29", "refseq_ac": "NP_775340", "gene_names_uniprotkb": "rpl35", "gene_names_refseq": "CHUNP6863; rpl35", "protein_names_uniprotkb": "Large ribosomal subunit protein uL29; 60S ribosomal protein L35", "protein_names_refseq": "60S ribosomal protein L35; large ribosomal subunit protein uL29", "tax_id": 7955, "disease": "Diamond-Blackfan anemia 19 (Disease Ontology:DOID:0111886)", "pathway": " (dre:192299); (R-DRE-156827); (R-DRE-1799339); (R-DRE-6791226); (R-DRE-72689); (R-DRE-975956); (R-DRE-975957); (R-DRE-9954709); (R-DRE-9954714); (R-DRE-9954716)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "12006978;15138505;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH554774.1, EH539107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EH554774.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Plays an essential role in early embryonic development (PubMed:12006978). May act as a haploinsufficient tumor suppressor (PubMed:15138505)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0030218 erythrocyte differentiation;GO:0006412 translation;GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8JHJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JHW2-1", "uniprot_id": "TSP3A_DANRE", "mass": 105591.0, "length": 962, "protein_name": "Thrombospondin-3a", "gene_name": "thbs3a", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "thbs3a; thbs3; tsp3; zgc:103461", "gene_names_refseq": "", "protein_names_uniprotkb": "Thrombospondin-3a; Thbs3a", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:252849); (R-DRE-186797)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12592708;40044042", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5U3J1", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0061053 somite development;GO:0060231 mesenchymal to epithelial transition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8JHW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JIR0-1", "uniprot_id": "BMI1A_DANRE", "mass": 36539.0, "length": 320, "protein_name": "Polycomb complex protein BMI-1-A", "gene_name": "bmi1a", "organism": "Zebrafish", "refseq_name": "polycomb complex protein BMI-1-A", "refseq_ac": "NP_919347", "gene_names_uniprotkb": "bmi1a; bmi1; pcgf4a; pcgf4; psc1; wu:fb17g03; wu:fd18f06", "gene_names_refseq": "bmi1a; bmi1; pcgf4; psc1; wu:fb17g03; wu:fd18f06", "protein_names_uniprotkb": "Polycomb complex protein BMI-1-A; Polycomb group RING finger protein 4-A", "protein_names_refseq": "B lymphoma Mo-MLV insertion region 1 homolog; B lymphoma Mo-MLV insertion region 1a; BMI1 proto-oncogene, polycomb ring fingera; bmi1 polycomb ring finger oncogene 1a; polycomb complex protein BMI-1-A; polycomb group RING finger protein 4-A; polycomb group ring finger 4", "tax_id": 7955, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal Wilms' tumor (Disease Ontology:DOID:5176); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (R-DRE-2559580); (R-DRE-3108214); (R-DRE-3899300); (R-DRE-4570464); (R-DRE-8939243); (R-DRE-8953750)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "12051733;15747776;39191496", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB074153.1, EH436779.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB074153.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. Cell growth maintenance, segment specification., [RefSeq, PubMed]; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWG4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045814 negative regulation of gene expression, epigenetic;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JIR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JIU7-1", "uniprot_id": "NACA_DANRE", "mass": 23400.0, "length": 215, "protein_name": "Nascent polypeptide-associated complex subunit alpha", "gene_name": "naca", "organism": "Zebrafish", "refseq_name": "nascent polypeptide-associated complex subunit alpha isoform 1", "refseq_ac": "NP_001180281", "gene_names_uniprotkb": "naca; ik:tdsubc_2b5; nkn; tdsubc_2b5; unm_t30953; xx:tdsubc_2b5", "gene_names_refseq": "ik:tdsubc_2b5; naca; nkn; tdsubc_2b5; unm_t30953; xx:tdsubc_2b5", "protein_names_uniprotkb": "Nascent polypeptide-associated complex subunit alpha; Alpha-NAC; NAC-alpha", "protein_names_refseq": "NAC-alpha; alpha-NAC; nascent polypeptide-associated complex alpha polypeptide; nascent polypeptide-associated complex alpha subunit; nascent polypeptide-associated complex subunit alpha isoform 1; no knack; sknac; unm t30953", "tax_id": 7955, "disease": "", "pathway": " (dre:195823)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;18307296;19211926;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395015.1991931.1, SRR26395012.1444927.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1 and AY398384.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), also known as the skeletal naca (sknac) isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May promote appropriate targeting of ribosome-nascent polypeptide complexes., [UniProtKB]; Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P3U9", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane;GO:0060216 definitive hemopoiesis;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8JIU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QGA2-1", "uniprot_id": "TIP39_DANRE", "mass": 17750.0, "length": 157, "protein_name": "Tuberoinfundibular peptide of 39 residues", "gene_name": "pth2", "organism": "Zebrafish", "refseq_name": "tuberoinfundibular peptide of 39 residues precursor", "refseq_ac": "NP_991140", "gene_names_uniprotkb": "pth2; tip39", "gene_names_refseq": "pth2; tip39", "protein_names_uniprotkb": "Tuberoinfundibular peptide of 39 residues; Parathyroid hormone 2; TIP39", "protein_names_refseq": "hypothalamic neuropeptide; tuberoinfundibular peptide of 39 amino acids; tuberoinfundibular peptide of 39 residues precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:402812); (R-DRE-373080)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15297442;21880859;23594743;33268890", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076066.1, CK361490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A single TIP39 gene was identified for zebrafish species, which showed significant homology to mammalian TIP39, [RefSeq, PubMed]; Data indicate that the expression of pth2 and pth2r mRNA in the ear at the same time suggesting a role in otic development., [RefSeq, PubMed]; Plays a role as a potent and selective agonist of pth2r resulting in adenyl cyclase activation and intracellular calcium level elevation., [UniProtKB, PubMed]; The neuropeptide Pth2 dynamically senses others via mechanosensation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q67FW3", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001964 startle response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8QGA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90267-1", "uniprot_id": "OTX1A_DANRE", "mass": 36145.0, "length": 338, "protein_name": "Homeobox protein OTX1 A", "gene_name": "otx1a", "organism": "Zebrafish", "refseq_name": "homeobox protein OTX1 A", "refseq_ac": "NP_571290", "gene_names_uniprotkb": "otx1a; otx1l; otx3; si:dkeyp-123h10.1", "gene_names_refseq": "otx1a; otx1l; otx2a; otx3", "protein_names_uniprotkb": "Homeobox protein OTX1 A; Orthodenticle homolog 1-like; zOtx3", "protein_names_refseq": "homeobox protein OTX1 A; homeobox protein Otx1l; orthodenticle homeobox 1a; orthodenticle homolog 1 like; orthodenticle homolog 1a; orthodenticle homolog 3; zOTX3", "tax_id": 7955, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:30462)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16611693;17670791;23594743;7898305;8619954", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC076432.1, D26174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076432.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Plays a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. Establishes and positions the zona limitans intrathalamica (ZLI) in the diencephalon. May play a role in the organizer function. Probably acts redundantly with otx2 in early brain development., [UniProtKB, PubMed, PubMed]; The Zona limitans intrathalamica is induced within the competence area established by Otx1l/2, and is posteriorly restricted by Irx1b., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A5Y6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030902 hindbrain development;GO:0021549 cerebellum development;GO:0030917 midbrain-hindbrain boundary development;GO:0003406 retinal pigment epithelium development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90435-1", "uniprot_id": "PO4F3_DANRE", "mass": 36550.0, "length": 331, "protein_name": "POU domain, class 4, transcription factor 3", "gene_name": "pou4f3", "organism": "Zebrafish", "refseq_name": "POU domain, class 4, transcription factor 3", "refseq_ac": "NP_571353", "gene_names_uniprotkb": "pou4f3; brn-3.1; brn-3c; brn3.1; brn3c", "gene_names_refseq": "BRN-3.1; brn-3c; brn3.1; brn3c; pou4f3", "protein_names_uniprotkb": "POU domain, class 4, transcription factor 3; Brain-3.1; Brain-specific homeobox/POU domain protein 3.1; zfBrn-3.1", "protein_names_refseq": "POU domain, class 4, transcription factor 3; brain POU domain gene 3.1; brain-3.1; brain-specific homeobox/POU domain protein 3.1; zfbrn-3.1", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 15 (Disease Ontology:DOID:0110546)", "pathway": " (dre:30534)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15042710;15930106;8605028", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY995217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY995217.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52NV5", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90459-1", "uniprot_id": "CCND1_DANRE", "mass": 33067.0, "length": 291, "protein_name": "G1/S-specific cyclin-D1", "gene_name": "ccnd1", "organism": "Zebrafish", "refseq_name": "G1/S-specific cyclin-D1", "refseq_ac": "NP_571100", "gene_names_uniprotkb": "ccnd1; cycd1", "gene_names_refseq": "cb161; ccnd1; cycd1; etID37810.7; fb52e01; fc45c08; fc83a12; id:ibd1198; wu:fb52e01; wu:fc45c08; wu:fc83a12", "protein_names_uniprotkb": "G1/S-specific cyclin-D1", "protein_names_refseq": "G1/S-specific cyclin-D1", "tax_id": 7955, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colon adenoma (Disease Ontology:DOID:0050912); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); penile benign neoplasm (Disease Ontology:DOID:11624); interstitial cystitis (Disease Ontology:DOID:13949); von Hippel-Lindau disease (Disease Ontology:DOID:14175); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); transitional cell carcinoma (Disease Ontology:DOID:2671); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); invasive lobular carcinoma (Disease Ontology:DOID:3457); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cancer (Disease Ontology:DOID:3571); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); lung small cell carcinoma (Disease Ontology:DOID:5409); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pancreatic solid pseudopapillary carcinoma (Disease Ontology:DOID:6827); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:30222); (R-DRE-187577); (R-DRE-3214858); (R-DRE-69231); (R-DRE-75815); (R-DRE-8849470); (R-DRE-8878166); (R-DRE-8934593); (R-DRE-8951936); (R-DRE-9754119); (R-DRE-9929491)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "8547308", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01015778.1, GFIL01003313.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505383, SAMEA3505384 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000007.1, EB896015.1, EH579652.1 and CT624760.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90459-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90482-1", "uniprot_id": "PO3F1_DANRE", "mass": 41433.0, "length": 368, "protein_name": "POU domain, class 3, transcription factor 1", "gene_name": "pou3f1", "organism": "Zebrafish", "refseq_name": "POU domain, class 3, transcription factor 1", "refseq_ac": "NP_571236", "gene_names_uniprotkb": "pou3f1; pou50; si:dkey-248g17.1; zp50pou; zp50", "gene_names_refseq": "pou3f1; pou50; wu:fc09d06; zp-50; zp50pou; zp50", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 1; POU domain protein 50; ZP-50", "protein_names_refseq": "Oct-6; POU domain gene 50; POU domain protein 50; POU domain protein ZP-50; POU domain, class 3, transcription factor 1", "tax_id": 7955, "disease": "", "pathway": " (dre:30398)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;8674416;9651490", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X96422.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X96422.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The expression of the zebrafish Oct-6 protein is consistent with the notion that it functions as a 'competence factor' in promyelin cells to execute the myelination program., [RefSeq, PubMed]; Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BGW5;A7MCK3;Q6NYY2", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90482-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90487-1", "uniprot_id": "HBA_DANRE", "mass": 15522.0, "length": 143, "protein_name": "Hemoglobin subunit alpha", "gene_name": "hbaa1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "hbaa1", "gene_names_refseq": "", "protein_names_uniprotkb": "Hemoglobin subunit alpha; Alpha-globin aa1; Hemoglobin alpha chain", "protein_names_refseq": "", "tax_id": 7955, "disease": "hemoglobin H disease (Disease Ontology:DOID:0110031); Heinz body anemia (Disease Ontology:DOID:0111363); familial erythrocytosis 7 (Disease Ontology:DOID:0111631); Alzheimer's disease (Disease Ontology:DOID:10652); alpha thalassemia (Disease Ontology:DOID:1099)", "pathway": " (dre:30507)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;40044042", "class_list": "", "function": "Involved in oxygen transport from gills to the various peripheral tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0001666 response to hypoxia;GO:0030097 hemopoiesis;GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90487-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90WY5-1", "uniprot_id": "ADA2B_DANRE", "mass": 55971.0, "length": 510, "protein_name": "Alpha-2B adrenergic receptor", "gene_name": "adra2b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "adra2b", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; Alpha-2BAR", "protein_names_refseq": "", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:266751); (R-DRE-390696); (R-DRE-392023); (R-DRE-418594); (R-DRE-418597)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "12949138;15655522", "class_list": "", "function": "Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is norepinephrine > epinephrine., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding;GO:0004936 alpha-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90WY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90WY6-1", "uniprot_id": "ADA2C_DANRE", "mass": 49137.0, "length": 432, "protein_name": "Alpha-2C adrenergic receptor", "gene_name": "adra2c", "organism": "Zebrafish", "refseq_name": "alpha-2C adrenergic receptor", "refseq_ac": "NP_997522", "gene_names_uniprotkb": "adra2c", "gene_names_refseq": "adra2c; zgc:194523; zgc:194541", "protein_names_uniprotkb": "Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2CAR", "protein_names_refseq": "adrenergic, alpha-2C-, receptor; alpha(2C)AR; alpha-2C adrenergic receptor; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2CAR", "tax_id": 7955, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:266752); (R-DRE-390696); (R-DRE-392023); (R-DRE-400042); (R-DRE-418594); (R-DRE-418597)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "12949138;15655522", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC163670.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY048969.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15655522). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity). The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine (PubMed:15655522)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004938 alpha2-adrenergic receptor activity;GO:0051379 epinephrine binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0019229 regulation of vasoconstriction;GO:0010700 negative regulation of norepinephrine secretion;GO:0030168 platelet activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90WY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90XG0-1", "uniprot_id": "TPISB_DANRE", "mass": 26828.0, "length": 248, "protein_name": "Triosephosphate isomerase B", "gene_name": "tpi1b", "organism": "Zebrafish", "refseq_name": "triosephosphate isomerase B", "refseq_ac": "NP_705954", "gene_names_uniprotkb": "tpi1b", "gene_names_refseq": "DrTPI-B; TIM-B; cb179; tpi1b; wu:fb51c02", "protein_names_uniprotkb": "Triosephosphate isomerase B; 4.2.3.3; 5.3.1.1; Methylglyoxal synthase B; TIM-B; Triose-phosphate isomerase B", "protein_names_refseq": "methylglyoxal synthase B; triose-phosphate isomerase B; triosephosphate isomerase B", "tax_id": 7955, "disease": "triosephosphate isomerase deficiency (Disease Ontology:DOID:0050884); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); carbohydrate metabolic disorder (Disease Ontology:DOID:2978); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (dre:560753); (R-DRE-70171); (R-DRE-70263)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11606544;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01003883.1, GDQQ01003396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On or before Nov 30, 2007 this sequence version replaced XP_684298.2, NP_705954.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids., [UniProtKB, UniProtKB]; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T315", "ec_number_list": "5.3.1.1;4.2.3.3", "go_molecular_function": "GO:0004807 triose-phosphate isomerase activity;GO:0042803 protein homodimerization activity;GO:0008929 methylglyoxal synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0019242 methylglyoxal biosynthetic process;GO:0046166 glyceraldehyde-3-phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90XG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Y50-1", "uniprot_id": "CXAR_DANRE", "mass": 40664.0, "length": 372, "protein_name": "Coxsackievirus and adenovirus receptor homolog", "gene_name": "cxadr", "organism": "Zebrafish", "refseq_name": "coxsackievirus and adenovirus receptor homolog precursor", "refseq_ac": "NP_694480", "gene_names_uniprotkb": "cxadr", "gene_names_refseq": "car; cb331; cxadr; fb76g12; wu:fb76g12", "protein_names_uniprotkb": "Coxsackievirus and adenovirus receptor homolog; CAR", "protein_names_refseq": "coxsackie virus and adenovirus receptor; coxsackievirus and adenovirus receptor homolog precursor; coxsackievirus and adenovirus receptor homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:791793); (R-DRE-198933); (R-DRE-202733)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11080637;12239327;18062954;23594743;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395062.411962.1, GFIL01007748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000010.1. On or before Dec 18, 2007 this sequence version replaced XP_001331434.1, XP_001341977.1., [RefSeq]; May function as a homophilic cell adhesion molecule and be essential for tight junction integrity. May also be involved in transepithelial migration of leukocytes through adhesive interactions with jaml. The interaction between both receptors may also mediate the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair (By similarity)., [UniProtKB]; These results establish a requirement for CAR in the terminal differentiation of renal glomerular and tubular cell types., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q804R4", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0014704 intercalated disc", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q90Y50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90YM8-1", "uniprot_id": "CYFP1_DANRE", "mass": 145174.0, "length": 1253, "protein_name": "Cytoplasmic FMR1-interacting protein 1 homolog", "gene_name": "cyfip1", "organism": "Zebrafish", "refseq_name": "cytoplasmic FMR1-interacting protein 1 homolog", "refseq_ac": "NP_997924", "gene_names_uniprotkb": "cyfip1", "gene_names_refseq": "CYFIP; CY; cyfip1; fb15a06; wu:fb15a06", "protein_names_uniprotkb": "Cytoplasmic FMR1-interacting protein 1 homolog", "protein_names_refseq": "cytoplasmic FMR1-interacting protein 1 homolog", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 15q11.2 deletion syndrome (Disease Ontology:DOID:0060393); Schaaf-Yang syndrome (Disease Ontology:DOID:0111715); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:336613); (R-DRE-2029482); (R-DRE-5663213); (R-DRE-6798695); (R-DRE-9013149); (R-DRE-9013404); (R-DRE-9013408); (R-DRE-9013423)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "11438699;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY017342.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY017342.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58ES3", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0030371 translation repressor activity;GO:0000340 RNA 7-methylguanosine cap binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0031209 SCAR complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0000902 cell morphogenesis;GO:0030032 lamellipodium assembly;GO:0008360 regulation of cell shape;GO:0031529 ruffle organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90YM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZL1-1", "uniprot_id": "MSGN1_DANRE", "mass": 14994.0, "length": 131, "protein_name": "Mesogenin-1", "gene_name": "msgn1", "organism": "Zebrafish", "refseq_name": "mesogenin-1", "refseq_ac": "NP_878302", "gene_names_uniprotkb": "msgn1; mespo; si:ch211-222h17.1", "gene_names_refseq": "Meso1a; mespo; msgn1; wu:fc39h09; zgc:109769", "protein_names_uniprotkb": "Mesogenin-1; MesP-related bHLH factor; Paraxial mesoderm-specific expression and regulatory capacities; pMesogenin1; pMsgn1", "protein_names_refseq": "mesP-related bHLH factor; mesogenin-1; pMeso1a; pMesogenin1; pMsgn1; paraxial mesoderm-specific expression and regulatory capacities", "tax_id": 7955, "disease": "", "pathway": " (dre:360135)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12684777;12883008;23594743;38448978", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BC092683.1, EH582872.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH582872.1 and JBMGRA010000004.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments, RNA-seq data and orthologous alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity)., [UniProtKB, PubMed]; Mespo expression is intensified in the involuting mesoderm at 60% epiboly, and then restricted to the presomitic mesoderm (PSM) at 95% epiboly. At the 1-somite stage, mespo expression becomes reduced in the most rostral PSM., [RefSeq, PubMed]; Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E564;Q568W3", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007525 somatic muscle development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001707 mesoderm formation;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90ZL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZM2-1", "uniprot_id": "S61A1_DANRE", "mass": 52298.0, "length": 476, "protein_name": "Protein transport protein Sec61 subunit alpha-like 1", "gene_name": "sec61al1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "sec61al1; sec61aa; sec61a", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein transport protein Sec61 subunit alpha-like 1", "protein_names_refseq": "", "tax_id": 7955, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); autosomal dominant tubulointerstitial kidney disease 5 (Disease Ontology:DOID:0061120); common variable immunodeficiency (Disease Ontology:DOID:12177)", "pathway": " (dre:192298)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27392076;40044042", "class_list": "", "function": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). Plays a role in the pronephric kidney tubule development (PubMed:27392076)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU31", "ec_number_list": "", "go_molecular_function": "GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005784 Sec61 translocon complex", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0006613 cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0039019 pronephric nephron development;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90ZM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZY4-1", "uniprot_id": "SBK1_DANRE", "mass": 43913.0, "length": 385, "protein_name": "Serine/threonine-protein kinase SBK1", "gene_name": "sbk1", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase SBK1", "refseq_ac": "NP_998006", "gene_names_uniprotkb": "sbk1; bsk146", "gene_names_refseq": "bsk146; sbk1", "protein_names_uniprotkb": "Serine/threonine-protein kinase SBK1; 2.7.11.1; Brain-specific protein kinase BSK146; SH3 domain-binding kinase 1", "protein_names_refseq": "SH3 domain-binding kinase 1; SH3-binding kinase 1; brain-specific protein kinase BSK146; protein kinase Bsk146; serine/threonine-protein kinase SBK1", "tax_id": 7955, "disease": "", "pathway": " (dre:405767)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16403448", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.15425475.1, SRR32588718.27192556.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476732, SAMEA4476741 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000012.1. On or before Sep 22, 2025 this sequence version replaced NP_001189435.1, XP_009304631.1, NP_998006.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; BSK146 is a brain-specific protein kinase zebrafish, [RefSeq, PubMed]; May be involved in the control of neuronal proliferation or migration in the brain of embryos., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90ZY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91981-1", "uniprot_id": "OTX2_DANRE", "mass": 31594.0, "length": 289, "protein_name": "Homeobox protein OTX2", "gene_name": "otx2", "organism": "Zebrafish", "refseq_name": "homeobox protein OTX2", "refseq_ac": "NP_571326", "gene_names_uniprotkb": "otx2", "gene_names_refseq": "id:ibd2915; otx2b; otx2; zOtx2; zgc:136535; zotx-2", "protein_names_uniprotkb": "Homeobox protein OTX2; Orthodenticle homolog 2; zOTX2", "protein_names_refseq": "etID309955.17; homeobox protein OTX2; orthodenticle homeobox 2; orthodenticle homolog 2", "tax_id": 7955, "disease": "combined pituitary hormone deficiency 6 (Disease Ontology:DOID:0061022); syndromic microphthalmia 5 (Disease Ontology:DOID:0111806); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:30501)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7893604;7898305", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U14592.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505373, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U14592.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030902 hindbrain development;GO:0021549 cerebellum development;GO:0030917 midbrain-hindbrain boundary development;GO:0003406 retinal pigment epithelium development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91981-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91994-1", "uniprot_id": "OTX1B_DANRE", "mass": 35208.0, "length": 323, "protein_name": "Homeobox protein OTX1 B", "gene_name": "otx1b", "organism": "Zebrafish", "refseq_name": "homeobox protein OTX1 B", "refseq_ac": "NP_571325", "gene_names_uniprotkb": "otx1b; otx1", "gene_names_refseq": "cb769; fj99f05; otx1b; otx1; wu:fj99f05; zOtx1", "protein_names_uniprotkb": "Homeobox protein OTX1 B; Orthodenticle homolog 1 B; zOtx1", "protein_names_refseq": "homeobox protein OTX1 B; orthodenticle homeobox 1b; orthodenticle homolog 1b", "tax_id": 7955, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:30500)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "7893604;7898305;8619954", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC045290.1, D26172.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC045290.1. On Dec 20, 2003 this sequence version replaced NP_571325.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZU54", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060875 lateral semicircular canal development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042472 inner ear morphogenesis;GO:0003406 retinal pigment epithelium development;GO:0030901 midbrain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91994-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92047-1", "uniprot_id": "PIMT_DANRE", "mass": 24725.0, "length": 228, "protein_name": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "gene_name": "pcmt", "organism": "Zebrafish", "refseq_name": "protein-L-isoaspartate(D-aspartate) O-methyltransferase", "refseq_ac": "NP_571540", "gene_names_uniprotkb": "pcmt", "gene_names_refseq": "etID309741.20; fj13d06; pcmt; pimt; wu:fj13d06", "protein_names_uniprotkb": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase; 2.1.1.77; L-isoaspartyl protein carboxyl methyltransferase; PIMT; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase", "protein_names_refseq": "l-isoaspartyl protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase; protein-L-isoaspartate (D-aspartate) O-methyltransferase 1; protein-L-isoaspartate(D-aspartate) O-methyltransferase; protein-beta-aspartate methyltransferase", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (dre:30751); (R-DRE-5676934)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9253175", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049067.1, GFIL01029687.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000020.1. On or before Aug 31, 2013 this sequence version replaced XP_005160363.1, XP_699550.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.77", "go_molecular_function": "GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006479 protein methylation;GO:0050848 regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92047-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92048-1", "uniprot_id": "WNT2_DANRE", "mass": 39789.0, "length": 350, "protein_name": "Protein Wnt-2", "gene_name": "wnt2", "organism": "Zebrafish", "refseq_name": "protein Wnt-2 precursor", "refseq_ac": "NP_571025", "gene_names_uniprotkb": "wnt2; wnt-2", "gene_names_refseq": "ZfWnt2; wnt-2; wnt2", "protein_names_uniprotkb": "Protein Wnt-2", "protein_names_refseq": "etID309852.18; protein Wnt-2 precursor; protein Wnt-2", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); urinary system cancer (Disease Ontology:DOID:3996); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:30127); (R-DRE-3238698)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U51266.1, BC056277.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U51266.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0001889 liver development;GO:0030182 neuron differentiation;GO:0042074 cell migration involved in gastrulation;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q92048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92051-1", "uniprot_id": "CAHZ_DANRE", "mass": 28677.0, "length": 260, "protein_name": "Carbonic anhydrase", "gene_name": "cahz", "organism": "Zebrafish", "refseq_name": "carbonic anhydrase", "refseq_ac": "NP_571185", "gene_names_uniprotkb": "cahz; cah-z", "gene_names_refseq": "CAH-Z; cahz; cah; cb588; id:ibd5016; wu:cegs2190; wu:fj65c09", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1; Carbonate dehydratase", "protein_names_refseq": "ca2b; carbonate dehydratase; carbonic anhydrase; zCA2-like b; zCAb", "tax_id": 7955, "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chronic pancreatitis (Disease Ontology:DOID:0051065); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Graves ophthalmopathy (Disease Ontology:DOID:0081120); autosomal recessive osteopetrosis 3 (Disease Ontology:DOID:0110941); primary biliary cholangitis (Disease Ontology:DOID:12236); lesion of sciatic nerve (Disease Ontology:DOID:12528); Sjogren's syndrome (Disease Ontology:DOID:12894); osteopetrosis (Disease Ontology:DOID:13533); major depressive disorder (Disease Ontology:DOID:1470); viral hepatitis (Disease Ontology:DOID:1884); Lynch syndrome (Disease Ontology:DOID:3883); bladder urothelial carcinoma (Disease Ontology:DOID:4006); alcoholic pancreatitis (Disease Ontology:DOID:4988); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30331); (R-DRE-1237044); (R-DRE-1247673); (R-DRE-1475029)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "40044042;9089083", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U55177.1, EH450298.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505382 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U55177.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Reversible hydration of carbon dioxide., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0042539 hypotonic salinity response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q92051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92052-1", "uniprot_id": "CXG1_DANRE", "mass": 43578.0, "length": 380, "protein_name": "Gap junction gamma-1 protein", "gene_name": "gjc1; gjc4b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "gjc1; gjc4b; cb232; cx43.4; gja7; gjc1; wu:fc46h11", "gene_names_refseq": "", "protein_names_uniprotkb": "Gap junction gamma-1 protein; Connexin-43.4; Cx43.4; Gap junction alpha-7 protein", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8806823", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Participates in a developmental pathway for formation of the notochord and tail., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q92053", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92052-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DEX7-1", "uniprot_id": "FADS2_DANRE", "mass": 52032.0, "length": 444, "protein_name": "Acyl-CoA 6-desaturase", "gene_name": "fads2", "organism": "Zebrafish", "refseq_name": "acyl-CoA 6-desaturase", "refseq_ac": "NP_571720", "gene_names_uniprotkb": "fads2; D6; Fadsd6; fadsd6; wu:fb64c04; wu:fb69e08; zgc:112502", "gene_names_refseq": "DRD5/D6; Fadsd6; fads2; wu:fb64c04; wu:fb69e08; zgc:112502", "protein_names_uniprotkb": "Acyl-CoA 6-desaturase; 1.14.19.3; 1.14.19.44; D5D/D6D fatty acid desaturase; Delta(5)/Delta(6) fatty acid desaturase; Delta-5/Delta-6 fatty acid desaturase; Fatty acid desaturase 2", "protein_names_refseq": "D5D/D6D fatty acid desaturase; acyl-CoA 6-desaturase; delta(5)/Delta(6) fatty acid desaturase; delta-6 fatty acyl desaturase", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); discrete subaortic stenosis (Disease Ontology:DOID:5804); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DRE-2046105); (R-DRE-2046106)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11724940;19025614", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049438.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC049438.1. On Feb 9, 2004 this sequence version replaced NP_571720.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Desaturase displayed significant upregulation in expression during the oocyte maturation stage. Publication Status: Online-Only, [RefSeq, PubMed]; Fatty acid desaturase with bifunctional delta-5 and delta-6 activities. Component of a lipid metabolic pathway that catalyzes the biosynthesis of polyunsaturated fatty acids (PUFA) with preference toward n-3 substrates and Delta-6 function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZWF3", "ec_number_list": "1.14.19.3;1.14.19.44", "go_molecular_function": "GO:0016213 acyl-CoA 6-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0062076 acyl-CoA (8-3)-desaturase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001889 liver development;GO:0006629 lipid metabolic process;GO:0006636 unsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DEX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DFG8-1", "uniprot_id": "MKRN2_DANRE", "mass": 46480.0, "length": 414, "protein_name": "E3 ubiquitin-protein ligase makorin-2", "gene_name": "mkrn2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "mkrn2", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase makorin-2; 2.3.2.27; RING-type E3 ubiquitin transferase makorin-2", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:170783)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11597136", "class_list": "", "function": "E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway (By similarity). Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0Z6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002862 negative regulation of inflammatory response to antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DFG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I8L5-1", "uniprot_id": "FA10A_DANRE", "mass": 14004.0, "length": 126, "protein_name": "Fatty acid-binding protein 10-A, liver basic", "gene_name": "fabp10a", "organism": "Zebrafish", "refseq_name": "fatty acid-binding protein 10-A, liver basic", "refseq_ac": "NP_694492", "gene_names_uniprotkb": "fabp10a; fabp10; zgc:103719; zgc:92741", "gene_names_refseq": "L-FABP; Lb-FABP; Lfabp; Zf-FABP10; fabp10a; fabp10; z-L-BABP; zgc:103719; zgc:92741", "protein_names_uniprotkb": "Fatty acid-binding protein 10-A, liver basic; Fatty acid-binding protein, liver; L-BABP; L-FABP; Liver bile acid-binding protein; Liver-type FABP; Liver-type fatty acid-binding protein; Zf-FABP10; Zf-Lb-FABP; z-L-BABP", "protein_names_refseq": "L-BABP; fatty acid binding protein 10, liver basic; fatty acid-binding protein 10-A, liver basic; fatty acid-binding protein 10; fatty acid-binding protein, liver; liver bile acid-binding protein; liver-type FABP; liver-type fatty acid binding protein; small cytosolic protein involved in lipid transport and metabolism; zf-Lb-FABP", "tax_id": 7955, "disease": "", "pathway": " (dre:171481)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11004494;12633865;12815620;16857010;17670743;29980668", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF254642.2, EH498835.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF254642.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Binds one cholate per subunit., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JHE8", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0032052 bile acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9I8L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I8P3-1", "uniprot_id": "NPY_DANRE", "mass": 11032.0, "length": 96, "protein_name": "Pro-neuropeptide Y", "gene_name": "npy", "organism": "Zebrafish", "refseq_name": "pro-neuropeptide Y precursor", "refseq_ac": "NP_571149", "gene_names_uniprotkb": "npy", "gene_names_refseq": "npy; si:dkey-22m8.5", "protein_names_uniprotkb": "Pro-neuropeptide Y; NPY; Neuropeptide tyrosine", "protein_names_refseq": "pro-neuropeptide Y precursor; pro-neuropeptide Y", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); peripheral artery disease (Disease Ontology:DOID:0050830); absence epilepsy (Disease Ontology:DOID:0070309); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); anxiety disorder (Disease Ontology:DOID:2030); arteriosclerosis (Disease Ontology:DOID:2349); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); median neuropathy (Disease Ontology:DOID:571); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:30281); (R-DRE-375276); (R-DRE-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10936170;15891072", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC162068.1, EH455144.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505389, SAMEA3505391 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC162071.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Developmental expression of zYb and zYc receptors suggests a role for neuropeptide Y (NPY) in organogenesis., [RefSeq, PubMed]; Ligand for neuropeptide Y receptors. Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding;GO:0031843 type 2 neuropeptide Y receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0071878 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007631 feeding behavior;GO:2000253 positive regulation of feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I8P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9N0-1", "uniprot_id": "DAP1B_DANRE", "mass": 12101.0, "length": 109, "protein_name": "Death-associated protein-like 1 homolog", "gene_name": "dap1b", "organism": "Zebrafish", "refseq_name": "death-associated protein-like 1 homolog", "refseq_ac": "NP_571648", "gene_names_uniprotkb": "dap1b; zgc:136540", "gene_names_refseq": "cb369; dap1b; hm:zeh0189; zgc:136540", "protein_names_uniprotkb": "Death-associated protein-like 1 homolog; Death-associated protein 1b", "protein_names_refseq": "death-associated protein-like 1 homolog", "tax_id": 7955, "disease": "", "pathway": " (dre:101885164); (dre:58094)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23594743;36653451", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC115168.1, EH456021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505379, SAMEA3505391 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC115168.1., [RefSeq]; Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36653451). Acts via its association with eiF5a (eif5a and eif5a2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (PubMed:36653451). Plays a key role in ribosome hibernation in the mature egg by preventing mRNA translation, leading to ribosome inactivation (PubMed:36653451). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (PubMed:36653451)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IYW0;Q1RM22", "ec_number_list": "", "go_molecular_function": "GO:0030371 translation repressor activity;GO:0043022 ribosome binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "", "go_biological_process": "GO:0097190 apoptotic signaling pathway;GO:0010507 negative regulation of autophagy;GO:0141014 ribosome hibernation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I9N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9MIY8-1", "uniprot_id": "COX1_DANRE", "mass": 56806.0, "length": 516, "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "mt-co1", "organism": "Zebrafish", "refseq_name": "cytochrome c oxidase subunit I", "refseq_ac": "NP_059333", "gene_names_uniprotkb": "mt-co1; coi; cox1; coxi; mtco1", "gene_names_refseq": "COX1; mtco1", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 1; 7.1.1.9; Cytochrome c oxidase polypeptide I", "protein_names_refseq": "cytochrome c oxidase subunit I", "tax_id": 7955, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:140539); (R-DRE-5628897); (R-DRE-611105); (R-DRE-9707564); (R-DRE-9837999); (R-DRE-9864848)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "11691861", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]; REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AAF74299. Method: conceptual translation., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52NI8", "ec_number_list": "1.17.99.9;7.1.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0046686 response to cadmium ion;GO:0051597 response to methylmercury;GO:0006119 oxidative phosphorylation;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9MIY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PTP1-1", "uniprot_id": "PCNA_DANRE", "mass": 28611.0, "length": 260, "protein_name": "DNA sliding clamp PCNA", "gene_name": "pcna", "organism": "Zebrafish", "refseq_name": "DNA sliding clamp PCNA", "refseq_ac": "NP_571479", "gene_names_uniprotkb": "pcna", "gene_names_refseq": "cb16; fa28e03; fb36g03; pcna; wu:fa28e03; wu:fb36g03", "protein_names_uniprotkb": "DNA sliding clamp PCNA; PCNA; Proliferating cell nuclear antigen", "protein_names_refseq": "DNA sliding clamp PCNA; etID36690.10", "tax_id": 7955, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); ataxia-telangiectasia-like disorder 2 (Disease Ontology:DOID:0081385); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); leiomyoma (Disease Ontology:DOID:127); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cancer (Disease Ontology:DOID:3571); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:30678); (R-DRE-110312); (R-DRE-110314); (R-DRE-110320); (R-DRE-174437); (R-DRE-4615885); (R-DRE-5358565); (R-DRE-5651801); (R-DRE-5655862); (R-DRE-5656121); (R-DRE-5656169); (R-DRE-5685942); (R-DRE-5693537); (R-DRE-5696397); (R-DRE-5696400); (R-DRE-6782135); (R-DRE-6782210); (R-DRE-6804114); (R-DRE-69091); (R-DRE-69166); (R-DRE-69183); (R-DRE-8866654)", "pathway_count": 22, "publication_count": 2, "publication_id_list": "18307296;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC049535.1, EH450164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476735, SAMEA4476795 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH446205.1 and BC064299.1. On or before Dec 6, 2013 this sequence version replaced XP_005155472.1, NP_571479.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZW84", "ec_number_list": "", "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0043626 PCNA complex;GO:0070557 PCNA-p21 complex;GO:0005634 nucleus", "go_biological_process": "GO:0006272 leading strand elongation;GO:0009617 response to bacterium;GO:0006298 mismatch repair;GO:0014823 response to activity;GO:0006275 regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9PTP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PTS2-1", "uniprot_id": "DCUP_DANRE", "mass": 41645.0, "length": 369, "protein_name": "Uroporphyrinogen decarboxylase", "gene_name": "urod", "organism": "Zebrafish", "refseq_name": "uroporphyrinogen decarboxylase", "refseq_ac": "NP_571422", "gene_names_uniprotkb": "urod", "gene_names_refseq": "urod; wu:fc43e09", "protein_names_uniprotkb": "Uroporphyrinogen decarboxylase; 4.1.1.37; UPD; URO-D", "protein_names_refseq": "UPD; URO-D; uroporphyrinogen decarboxylase; yqe; yquem", "tax_id": 7955, "disease": "porphyria (Disease Ontology:DOID:13268); breast cancer (Disease Ontology:DOID:1612); porphyria cutanea tarda (Disease Ontology:DOID:3132); hepatoerythropoietic porphyria (Disease Ontology:DOID:5230)", "pathway": " (dre:30617); (R-DRE-189451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "40044042;9806541", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF095639.1, BC108075.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA4476736, SAMEA4476738 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF095639.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (By similarity). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:9806541)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.37", "go_molecular_function": "GO:0004853 uroporphyrinogen decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0006778 porphyrin-containing compound metabolic process;GO:0006787 porphyrin-containing compound catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9PTS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PU65-1", "uniprot_id": "GCNFA_DANRE", "mass": 54056.0, "length": 477, "protein_name": "Nuclear receptor subfamily 6 group A member 1-A", "gene_name": "nr6a1a", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 6 group A member 1-A", "refseq_ac": "NP_571331", "gene_names_uniprotkb": "nr6a1a; gcnf", "gene_names_refseq": "gcnf; nr6a1a; nr6a1; zfGCNF", "protein_names_uniprotkb": "Nuclear receptor subfamily 6 group A member 1-A; GCNF-A; Germ cell nuclear factor A; zfGCNF", "protein_names_refseq": "GCNF-A; germ cell nuclear factor A; nuclear receptor subfamily 6 group A member 1-A", "tax_id": 7955, "disease": "", "pathway": " (dre:30506); (R-DRE-383280)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10398411;40610405", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ007703.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ007703.2. On Dec 6, 2006 this sequence version replaced NP_571331.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cloning and expression of the zebrafish germ cell nuclear factor., [RefSeq, PubMed]; Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0042562 hormone binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016477 cell migration;GO:0033993 response to lipid;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9PU65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PUS3-1", "uniprot_id": "Q9PUS3_DANRE", "mass": 23432.0, "length": 218, "protein_name": "Proteasome subunit beta", "gene_name": "psmb9a", "organism": "Zebrafish", "refseq_name": "proteasome subunit beta type-9", "refseq_ac": "NP_571466", "gene_names_uniprotkb": "psmb9a; beta1ia; lmp2; macropain; prosome; psmb9; wu:fa66f04; wu:fj22d05; zgc:91842", "gene_names_refseq": "beta1ia; lmp2; macropain; prosome; psmb9a; psmb9; wu:fa66f04; wu:fj22d05; zgc:91842", "protein_names_uniprotkb": "Proteasome subunit beta", "protein_names_refseq": "large multifunctional protease 2; proteasome (prosome, macropain) subunit, beta type, 9a; proteasome subunit beta 9a; proteasome subunit beta type-9; proteosome (prosome, macropain) subunit, beta type 9", "tax_id": 7955, "disease": "lymphoma (Disease Ontology:DOID:0060058); colorectal carcinoma (Disease Ontology:DOID:0080199); adult respiratory distress syndrome (Disease Ontology:DOID:11394); vitiligo (Disease Ontology:DOID:12306); Huntington's disease (Disease Ontology:DOID:12858); peptic esophagitis (Disease Ontology:DOID:13976); multiple sclerosis (Disease Ontology:DOID:2377); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); ankylosing spondylitis (Disease Ontology:DOID:7147); autoimmune thyroiditis (Disease Ontology:DOID:7188); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (dre:30665); (R-DRE-1236974); (R-DRE-1236978); (R-DRE-9907900); (R-DRE-9912633)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "11814690;12869198;16109975;16448862;19159490;29471808;31900206;34111665;36532084;36574072;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC078384.1, EH445987.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505387, SAMEA4476745 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078384.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LWX9", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0071222 cellular response to lipopolysaccharide;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0002376 immune system process;GO:0071219 cellular response to molecule of bacterial origin", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9PUS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6A6-1", "uniprot_id": "OPSG4_DANRE", "mass": 38706.0, "length": 349, "protein_name": "Green-sensitive opsin-4", "gene_name": "opn1mw4", "organism": "Zebrafish", "refseq_name": "green-sensitive opsin-4", "refseq_ac": "NP_571329", "gene_names_uniprotkb": "opn1mw4; grops2; rh24", "gene_names_refseq": "RH2-4; grops2; opn1mw4; rh2.4; wu:fk64b02; zfgr2", "protein_names_uniprotkb": "Green-sensitive opsin-4; Green cone photoreceptor pigment 4; Opsin RH2-4; Opsin-1, medium-wave-sensitive 4", "protein_names_refseq": "green cone photoreceptor pigment 4; green-sensitive opsin 2; green-sensitive opsin-4; immunolocalized to double cone outer segments; opsin RH2-4; opsin-1, medium-wave-sensitive 4; rhodopsin-like-2.4 cone opsin", "tax_id": 7955, "disease": "", "pathway": " (dre:30504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10349976;12618404;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF109370.1, BC059503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708836, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF109370.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to medium-wavelength (green) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8AYM6", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W6A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6A8-1", "uniprot_id": "OP1S2_DANRE", "mass": 39484.0, "length": 354, "protein_name": "Opsin-1, short-wave-sensitive 2", "gene_name": "opn1sw2", "organism": "Zebrafish", "refseq_name": "opsin-1, short-wave-sensitive 2", "refseq_ac": "NP_571267", "gene_names_uniprotkb": "opn1sw2; SI:zK13A21.5; SWS2; bluops; opn1sw1; sws2; zfblue", "gene_names_refseq": "SI:zK13A21.5; SWS2; bluops; opn1sw2; zfblue", "protein_names_uniprotkb": "Opsin-1, short-wave-sensitive 2; Blue cone photoreceptor pigment; Blue-sensitive opsin; Opsin SWS-2", "protein_names_refseq": "blue cone opsin; blue cone photoreceptor pigment; blue-sensitive opsin; immunolocalized to long single cone outer segments; opsin SWS-2; opsin-1, short-wave-sensitive 2; short-wavelength-sensitive-2 cone opsin", "tax_id": 7955, "disease": "", "pathway": " (dre:30435)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10349976;12618404;23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC062277.1, AF109372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; G protein-coupled photoreceptor that selectively activates G(i) proteins in response to short-wavelength (blue-violet) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade., [UniProtKB, UniProtKB]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0009882 blue light photoreceptor activity;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0009584 detection of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W6A8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6A9-1", "uniprot_id": "OP1S1_DANRE", "mass": 37268.0, "length": 336, "protein_name": "Opsin-1, short-wave-sensitive 1", "gene_name": "opn1sw1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "opn1sw1; opn1sw2; sws1; uvops", "gene_names_refseq": "", "protein_names_uniprotkb": "Opsin-1, short-wave-sensitive 1; Opsin SWS-1; Ultraviolet cone photoreceptor pigment; Ultraviolet-sensitive opsin", "protein_names_refseq": "", "tax_id": 7955, "disease": "blue color blindness (Disease Ontology:DOID:11661)", "pathway": " (dre:30582); (R-DRE-2187335); (R-DRE-418594); (R-DRE-419771)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10349976;12618404", "class_list": "", "function": "G protein-coupled photoreceptor that selectively activates G(i) proteins in response to short-wavelength (blue-violet) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8AYM5", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W6A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W741-1", "uniprot_id": "NOGG1_DANRE", "mass": 25093.0, "length": 216, "protein_name": "Noggin-1", "gene_name": "nog1", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "nog1", "gene_names_refseq": "", "protein_names_uniprotkb": "Noggin-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "proximal symphalangism (Disease Ontology:DOID:0050788); tarsal-carpal coalition syndrome (Disease Ontology:DOID:0050789); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); proximal symphalangism 1 (Disease Ontology:DOID:0080787); multiple synostoses syndrome 1 (Disease Ontology:DOID:0081317); brachydactyly type B2 (Disease Ontology:DOID:0110975); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); craniosynostosis (Disease Ontology:DOID:2340); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hyperopia (Disease Ontology:DOID:9834)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10491267", "class_list": "", "function": "Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0045202 synapse", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0001649 osteoblast differentiation;GO:0009953 dorsal/ventral pattern formation;GO:0051216 cartilage development;GO:0042664 negative regulation of endodermal cell fate specification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W741-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YHV3-1", "uniprot_id": "NOGG3_DANRE", "mass": 26029.0, "length": 223, "protein_name": "Noggin-3", "gene_name": "nog3", "organism": "Zebrafish", "refseq_name": "noggin-3 precursor", "refseq_ac": "NP_571057", "gene_names_uniprotkb": "nog3", "gene_names_refseq": "nog3", "protein_names_uniprotkb": "Noggin-3", "protein_names_refseq": "noggin-3 precursor", "tax_id": 7955, "disease": "proximal symphalangism (Disease Ontology:DOID:0050788); tarsal-carpal coalition syndrome (Disease Ontology:DOID:0050789); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); proximal symphalangism 1 (Disease Ontology:DOID:0080787); multiple synostoses syndrome 1 (Disease Ontology:DOID:0081317); brachydactyly type B2 (Disease Ontology:DOID:0110975); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); craniosynostosis (Disease Ontology:DOID:2340); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hyperopia (Disease Ontology:DOID:9834)", "pathway": " (dre:30173); (R-DRE-201451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10491267;9882485", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF084949.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF084949.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0007368 determination of left/right symmetry;GO:0001649 osteoblast differentiation;GO:0035844 cloaca development;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9YHV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YHX4-1", "uniprot_id": "SEM4E_DANRE", "mass": 85617.0, "length": 766, "protein_name": "Semaphorin-4E", "gene_name": "sema4e", "organism": "Zebrafish", "refseq_name": "semaphorin-4E precursor", "refseq_ac": "NP_571124", "gene_names_uniprotkb": "sema4e; sema7; semaZ7; semaz7", "gene_names_refseq": "sema4e; sema7; semaZ7", "protein_names_uniprotkb": "Semaphorin-4E; Sema Z7; Semaphorin-7; Semaphorin-Z7", "protein_names_refseq": "sema Z7; semaphorin-4E precursor; semaphorin-4E; semaphorin-7; semaphorin-Z7", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-416550); (R-DRE-416572)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9867349", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155168.1, SRR32588723.867432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMN02418766 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Jul 8, 2025 this sequence version replaced NP_571124.1., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YHX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YHZ5-1", "uniprot_id": "PIM2_DANRE", "mass": 35102.0, "length": 310, "protein_name": "Serine/threonine-protein kinase pim-2", "gene_name": "pim2", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "pim2; cb1068; fj47b05; pim1; si:dkey-83k24.1; wu:fj47b05", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase pim-2; 2.7.11.1; Kinase pim-1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:58054)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10079300;15520368;23300608;23594743;26469318;32372324;32703938;35134499;36314827", "class_list": "", "function": "Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0UYD2;Q6DI52;Q7ZVJ5;Q8JFW9", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9YHZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X1WE18-1", "uniprot_id": "KANK2_DANRE", "mass": 116153.0, "length": 1085, "protein_name": "KN motif and ankyrin repeat domain-containing protein 2", "gene_name": "kank2", "organism": "Zebrafish", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 2", "refseq_ac": "NP_001292549", "gene_names_uniprotkb": "kank2; dZ118J2.12; si:busm1-118j2.12; si:ch73-108m21.1", "gene_names_refseq": "dZ118J2.12; kank2; si:busm1-118j2.12; si:ch73-108m21.1", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 2", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 2", "tax_id": 7955, "disease": "palmoplantar keratoderma and woolly hair (Disease Ontology:DOID:0070554); nephrotic syndrome type 16 (Disease Ontology:DOID:0080272); cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23594743;25961457", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.1636028.1, SRR32588728.48712267.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505389 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Knockdown of kank2 in zebrafish recapitulated a nephrotic syndrome phenotype, resulting in proteinuria and podocyte foot process effacement, [RefSeq, PubMed]; May be involved in different biological processes including transcription and apoptosis by sequestering specific proteins outside of the nucleus (By similarity). Involved in actin stress fibers formation probably through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0070563 negative regulation of vitamin D receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "X1WE18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X1WER2-1", "uniprot_id": "UBA5_DANRE", "mass": 44234.0, "length": 398, "protein_name": "Ubiquitin-like modifier-activating enzyme 5", "gene_name": "uba5", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "uba5", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme 5", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (R-DRE-983168)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23594743;27545681;40044042", "class_list": "", "function": "E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates ufm1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ufm1-E1 thioester and free AMP. Activates ufm1 via a trans-binding mechanism, in which ufm1 interacts with distinct sites in both subunits of the uba5 homodimer. Trans-binding also promotes stabilization of the uba5 homodimer, and enhances ATP-binding. Transfer of ufm1 from uba5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071566 UFM1 activating enzyme activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0030218 erythrocyte differentiation;GO:0034976 response to endoplasmic reticulum stress;GO:0040011 locomotion;GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "X1WER2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X1WET9-1", "uniprot_id": "X1WET9_DANRE", "mass": 79648.0, "length": 681, "protein_name": "Eukaryotic translation initiation factor 3 subunit B", "gene_name": "eif3ba", "organism": "Zebrafish", "refseq_name": "eukaryotic translation initiation factor 3, subunit Ba", "refseq_ac": "NP_001277022", "gene_names_uniprotkb": "eif3ba; EIF3B; EIF3S9; eif3b; eif3s9; im:7152633; wu:fc17c01", "gene_names_refseq": "eif3ba; eif3b; eif3s9; im:7152633; wu:fc17c01", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit B; Eukaryotic translation initiation factor 3 subunit 9; eIF-3-eta; eIF3b", "protein_names_refseq": "eukaryotic translation initiation factor 3, subunit 9 eta; eukaryotic translation initiation factor 3, subunit Ba; eukaryotic translation initiation factor 3, subunit B", "tax_id": 7955, "disease": "", "pathway": " (dre:796380); (R-DRE-156827); (R-DRE-72649); (R-DRE-72689); (R-DRE-72695); (R-DRE-72702)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "16109975;23791820;26469318;28252024;31193955", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH442533.1, EH433087.1, CT625386.2, EB794365.1, EH468414.1 and CT593959.2. On Feb 25, 2014 this sequence version replaced XP_001335480.2., [RefSeq]; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome., [UniProtKB, UniProtKB]; Eif3ba has a role in regulating cranial neural crest development by modulating p53 in zebrafish, [RefSeq, PubMed]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P0I6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0014032 neural crest cell development;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0003313 heart rudiment development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "X1WET9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X1WHE3-1", "uniprot_id": "X1WHE3_DANRE", "mass": 245593.0, "length": 2213, "protein_name": "Sortilin-related receptor", "gene_name": "sorl1", "organism": "Zebrafish", "refseq_name": "sortilin-related receptor isoform X1", "refseq_ac": "XP_005157607", "gene_names_uniprotkb": "sorl1", "gene_names_refseq": "sorl1", "protein_names_uniprotkb": "Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; Sorting protein-related receptor containing LDLR class A repeats", "protein_names_refseq": "sortilin-related receptor isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dre:497306)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2B4D2", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0006897 endocytosis;GO:0006622 protein targeting to lysosome;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "X1WHE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1LWY1-1", "uniprot_id": "Q1LWY1_DANRE", "mass": 30298.0, "length": 281, "protein_name": "Proteasome subunit beta", "gene_name": "psmb13a", "organism": "Zebrafish", "refseq_name": "proteasome 20S subunit beta 13a", "refseq_ac": "NP_571752", "gene_names_uniprotkb": "psmb13a; beta2ta; psmb10; psmb12; zgc:110363", "gene_names_refseq": "beta2ta; psmb10; psmb12; psmb13a; zgc:110363", "protein_names_uniprotkb": "Proteasome subunit beta", "protein_names_refseq": "macropain; prosome; proteasome 20S subunit beta 13a; proteasome subunit beta 13a", "tax_id": 7955, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010)", "pathway": " (dre:64280)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11814690;19159490;21346254;21354627;24683187;26469318;27189481;27493218;29471808", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC092899.1, AF155577.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000019.1. On Aug 3, 2018 this sequence version replaced NP_571752.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005839 proteasome core complex;GO:0000502 proteasome complex", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q1LWY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AWT1-1", "uniprot_id": "A0A8M3AWT1_DANRE", "mass": 28410.0, "length": 266, "protein_name": "Histone H2A", "gene_name": "si:dkey-261m9.11", "organism": "Zebrafish", "refseq_name": "LOW QUALITY PROTEIN: uncharacterized protein si:dkey-261m9.11", "refseq_ac": "XP_009296467", "gene_names_uniprotkb": "si:dkey-261m9.11", "gene_names_refseq": "si:dkey-261m9.11", "protein_names_uniprotkb": "Histone H2A", "protein_names_refseq": "LOW QUALITY PROTEIN: uncharacterized protein si:dkey-261m9.11", "tax_id": 7955, "disease": "", "pathway": " (dre:563177)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## internal stop codons :: corrected 2 genomic stop codon ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_009296467.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AWT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9P9U0-1", "uniprot_id": "A0A8M9P9U0_DANRE", "mass": 47715.0, "length": 433, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "LOC108179096", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_021327722", "gene_names_uniprotkb": "LOC108179096", "gene_names_refseq": "LOC108179096", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:108179096)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021327722.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9P9U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M9PBH7-1", "uniprot_id": "A0A8M9PBH7_DANRE", "mass": 47736.0, "length": 418, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr80", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2 isoform X1", "refseq_ac": "XP_021323998", "gene_names_uniprotkb": "pimr80", "gene_names_refseq": "pimr80", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100034488)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_021323998.2. COMPLETENESS: full length., [RefSeq]; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M9PBH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1QTF7-1", "uniprot_id": "F1QTF7_DANRE", "mass": 36421.0, "length": 323, "protein_name": "Odorant receptor 132-1 isoform X1", "gene_name": "or92a1", "organism": "Zebrafish", "refseq_name": "odorant receptor 132-1 isoform X1", "refseq_ac": "XP_009293550", "gene_names_uniprotkb": "or92a1; or132-1; or21.35", "gene_names_refseq": "or132-1; or21.35; or92a1", "protein_names_uniprotkb": "Odorant receptor 132-1 isoform X1", "protein_names_refseq": "odorant receptor 132-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100147882)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15824306;16332259;20333175;21834959;26108469;32295537;36944644", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_009293550.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B4M4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F1QTF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QL49-1", "uniprot_id": "A0A8M1QL49_DANRE", "mass": 107805.0, "length": 981, "protein_name": "Seizure protein 6 isoform X1", "gene_name": "sez6a", "organism": "Zebrafish", "refseq_name": "seizure protein 6 isoform X1", "refseq_ac": "XP_001919970", "gene_names_uniprotkb": "sez6a", "gene_names_refseq": "sez6a", "protein_names_uniprotkb": "Seizure protein 6 isoform X1", "protein_names_refseq": "seizure protein 6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562079)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001919970.5. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0060074 synapse maturation;GO:0050773 regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QL49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QL80-1", "uniprot_id": "A0A8M1QL80_DANRE", "mass": 75946.0, "length": 681, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC100150106", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_001920484", "gene_names_uniprotkb": "LOC100150106", "gene_names_refseq": "LOC100150106", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100150106)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001920484.8. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QL80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B609-1", "uniprot_id": "A0A8M2B609_DANRE", "mass": 34123.0, "length": 313, "protein_name": "Upstream stimulatory factor 2", "gene_name": "usf2", "organism": "Zebrafish", "refseq_name": "upstream stimulatory factor 2 isoform X2", "refseq_ac": "XP_005159510", "gene_names_uniprotkb": "usf2; fb12g11; si:dkey-211g8.3; wu:fb12g11", "gene_names_refseq": "fb12g11; si:dkey-211g8.3; usf2; wu:fb12g11", "protein_names_uniprotkb": "Upstream stimulatory factor 2; Major late transcription factor 2; Upstream transcription factor 2", "protein_names_refseq": "upstream stimulatory factor 2 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:567297)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19449054;26469318;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B609-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4D0-1", "uniprot_id": "A0A8M2B4D0_DANRE", "mass": 32479.0, "length": 299, "protein_name": "Upstream stimulatory factor 1", "gene_name": "usf1", "organism": "Zebrafish", "refseq_name": "upstream stimulatory factor 1 isoform X4", "refseq_ac": "XP_005157565", "gene_names_uniprotkb": "usf1; zgc:56547", "gene_names_refseq": "usf1; zgc:56547", "protein_names_uniprotkb": "Upstream stimulatory factor 1", "protein_names_refseq": "upstream stimulatory factor 1 isoform X4", "tax_id": 7955, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-DRE-9824585)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IXK2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5G4-1", "uniprot_id": "A0A8M2B5G4_DANRE", "mass": 126361.0, "length": 1094, "protein_name": "Structural maintenance of chromosomes protein 6", "gene_name": "smc6", "organism": "Zebrafish", "refseq_name": "structural maintenance of chromosomes protein 6 isoform X1", "refseq_ac": "XP_005158646", "gene_names_uniprotkb": "smc6", "gene_names_refseq": "smc6", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 6", "protein_names_refseq": "structural maintenance of chromosomes protein 6 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HQA0;A0AC58HQG1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4A1-1", "uniprot_id": "A0A8M2B4A1_DANRE", "mass": 228336.0, "length": 2089, "protein_name": "Cell adhesion molecule DSCAML1 isoform X1", "gene_name": "dscaml1", "organism": "Zebrafish", "refseq_name": "cell adhesion molecule DSCAML1 isoform X1", "refseq_ac": "XP_005157551", "gene_names_uniprotkb": "dscaml1", "gene_names_refseq": "dscaml1", "protein_names_uniprotkb": "Cell adhesion molecule DSCAML1 isoform X1", "protein_names_refseq": "cell adhesion molecule DSCAML1 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); ocular motor apraxia, Cogan type (Disease Ontology:DOID:0080849); ocular motility disease (Disease Ontology:DOID:1279); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (dre:100002762)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_005157551.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030424 axon", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0007417 central nervous system development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3X4-1", "uniprot_id": "A0A8M2B3X4_DANRE", "mass": 35430.0, "length": 329, "protein_name": "RNA-binding protein Musashi homolog 2", "gene_name": "msi2b", "organism": "Zebrafish", "refseq_name": "RNA-binding protein Musashi homolog 2b isoform X20", "refseq_ac": "XP_005157743", "gene_names_uniprotkb": "msi2b; msi2; zgc:174035; zgc:63812", "gene_names_refseq": "msi2b; msi2; zgc:174035; zgc:63812", "protein_names_uniprotkb": "RNA-binding protein Musashi homolog 2", "protein_names_refseq": "RNA-binding protein Musashi homolog 2b isoform X20", "tax_id": 7955, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HAH1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0021772 olfactory bulb development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B482-1", "uniprot_id": "A0A8M2B482_DANRE", "mass": 237730.0, "length": 2060, "protein_name": "Uncharacterized protein myh14 isoform X1", "gene_name": "myh14", "organism": "Zebrafish", "refseq_name": "uncharacterized protein myh14 isoform X1", "refseq_ac": "XP_005157988", "gene_names_uniprotkb": "myh14", "gene_names_refseq": "myh14", "protein_names_uniprotkb": "Uncharacterized protein myh14 isoform X1", "protein_names_refseq": "uncharacterized protein myh14 isoform X1", "tax_id": 7955, "disease": "MYH-9 related disease (Disease Ontology:DOID:0060651); autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dre:563011)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005157988.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0016459 myosin complex", "go_biological_process": "GO:0048731 system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B482-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4R1-1", "uniprot_id": "A0A8M2B4R1_DANRE", "mass": 67154.0, "length": 584, "protein_name": "Glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1", "gene_name": "gdpd5b", "organism": "Zebrafish", "refseq_name": "glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1", "refseq_ac": "XP_005157799", "gene_names_uniprotkb": "gdpd5b", "gene_names_refseq": "gdpd5b", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1", "protein_names_refseq": "glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:560645)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7EY39", "ec_number_list": "", "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0003401 axis elongation;GO:0045597 positive regulation of cell differentiation;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4B7-1", "uniprot_id": "A0A8M2B4B7_DANRE", "mass": 203395.0, "length": 1850, "protein_name": "Protein virilizer homolog isoform X1", "gene_name": "virma", "organism": "Zebrafish", "refseq_name": "protein virilizer homolog isoform X1", "refseq_ac": "XP_005158091", "gene_names_uniprotkb": "virma", "gene_names_refseq": "virma", "protein_names_uniprotkb": "Protein virilizer homolog isoform X1", "protein_names_refseq": "protein virilizer homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:560260)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0036396 RNA N6-methyladenosine methyltransferase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5C5-1", "uniprot_id": "A0A8M2B5C5_DANRE", "mass": 93284.0, "length": 832, "protein_name": "SATB homeobox 1b isoform X1", "gene_name": "satb1b", "organism": "Zebrafish", "refseq_name": "SATB homeobox 1b isoform X1", "refseq_ac": "XP_005158488", "gene_names_uniprotkb": "satb1b; fk82h07; wu:fk82h07", "gene_names_refseq": "fk82h07; satb1b; wu:fk82h07", "protein_names_uniprotkb": "SATB homeobox 1b isoform X1", "protein_names_refseq": "SATB homeobox 1b isoform X1", "tax_id": 7955, "disease": "SATB2-associated syndrome (Disease Ontology:DOID:0060428); Sjogren's syndrome (Disease Ontology:DOID:12894)", "pathway": " (dre:571757)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24240475;25010335;26469318;27189481;30929901;37002478", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005158488.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HH73;A0AC58HH76;A0AC58HH83;A0AC58HH84;A0AC58HH88;A0AC58HH94;A0AC58HH99", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0031981 nuclear lumen", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030099 myeloid cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B5C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMB9-1", "uniprot_id": "A0A8M1RMB9_DANRE", "mass": 18042.0, "length": 167, "protein_name": "Transmembrane protein 196", "gene_name": "tmem196b", "organism": "Zebrafish", "refseq_name": "transmembrane protein 196 isoform X1", "refseq_ac": "XP_002664909", "gene_names_uniprotkb": "tmem196b", "gene_names_refseq": "tmem196b", "protein_names_uniprotkb": "Transmembrane protein 196", "protein_names_refseq": "transmembrane protein 196 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100330359)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002664909.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5Y0-1", "uniprot_id": "A0A8M2B5Y0_DANRE", "mass": 63813.0, "length": 596, "protein_name": "Zinc finger protein 384a isoform X1", "gene_name": "znf384a", "organism": "Zebrafish", "refseq_name": "zinc finger protein 384a isoform X1", "refseq_ac": "XP_005159474", "gene_names_uniprotkb": "znf384a; sb:eu279; si:busm1-44o19.5; si:dz44o19.5; znf384l", "gene_names_refseq": "sb:eu279; si:busm1-44o19.5; si:dz44o19.5; znf384a; znf384l", "protein_names_uniprotkb": "Zinc finger protein 384a isoform X1", "protein_names_refseq": "zinc finger protein 384a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5Y0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4P3-1", "uniprot_id": "A0A8M2B4P3_DANRE", "mass": 89125.0, "length": 783, "protein_name": "Transcription elongation factor A protein 3 isoform X1", "gene_name": "tcea3", "organism": "Zebrafish", "refseq_name": "transcription elongation factor A protein 3 isoform X1", "refseq_ac": "XP_005158394", "gene_names_uniprotkb": "tcea3; zgc:77732", "gene_names_refseq": "tcea3; zgc:77732", "protein_names_uniprotkb": "Transcription elongation factor A protein 3 isoform X1", "protein_names_refseq": "transcription elongation factor A protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003746 translation elongation factor activity;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7K9-1", "uniprot_id": "A0A8M2B7K9_DANRE", "mass": 56532.0, "length": 495, "protein_name": "Centrosomal protein 57kDa-like protein 1", "gene_name": "cep57l1", "organism": "Zebrafish", "refseq_name": "centrosomal protein CEP57L1 isoform X1", "refseq_ac": "XP_005160735", "gene_names_uniprotkb": "cep57l1; zgc:101037", "gene_names_refseq": "cep57l1; zgc:101037", "protein_names_uniprotkb": "Centrosomal protein 57kDa-like protein 1; Cep57-related protein", "protein_names_refseq": "centrosomal protein CEP57L1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:445312)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;26469318;27519738;30905685", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B7K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5Z3-1", "uniprot_id": "A0A8M2B5Z3_DANRE", "mass": 30266.0, "length": 266, "protein_name": "Tetraspanin", "gene_name": "tspan33b", "organism": "Zebrafish", "refseq_name": "tetraspanin-33b isoform X1", "refseq_ac": "XP_005159085", "gene_names_uniprotkb": "tspan33b; si:ch211-59c24.1", "gene_names_refseq": "si:ch211-59c24.1; tspan33b", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "tetraspanin-33b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:567512)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25601102", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0016020 membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0046930 pore complex", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046931 pore complex assembly;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2B5Z3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5T1-1", "uniprot_id": "A0A8M2B5T1_DANRE", "mass": 69073.0, "length": 621, "protein_name": "Sodium/potassium/calcium exchanger 4a isoform X1", "gene_name": "slc24a4a", "organism": "Zebrafish", "refseq_name": "sodium/potassium/calcium exchanger 4a isoform X1", "refseq_ac": "XP_005158898", "gene_names_uniprotkb": "slc24a4a; zgc:112072", "gene_names_refseq": "slc24a4a; zgc:112072", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 4a isoform X1", "protein_names_refseq": "sodium/potassium/calcium exchanger 4a isoform X1", "tax_id": 7955, "disease": "amelogenesis imperfecta hypomaturation type 2A5 (Disease Ontology:DOID:0110063); pigmentation disease (Disease Ontology:DOID:10123); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:550467)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20333216;27189481;28252024;28650316;33435938;34985194", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008273 calcium, potassium:sodium antiporter activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B5T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QV55-1", "uniprot_id": "A0A8M1QV55_DANRE", "mass": 60527.0, "length": 542, "protein_name": "Vasopressin V2 receptor isoform X1", "gene_name": "avpr2ab", "organism": "Zebrafish", "refseq_name": "vasopressin V2 receptor isoform X1", "refseq_ac": "XP_001922042", "gene_names_uniprotkb": "avpr2ab", "gene_names_refseq": "avpr2ab", "protein_names_uniprotkb": "Vasopressin V2 receptor isoform X1", "protein_names_refseq": "vasopressin V2 receptor isoform X1", "tax_id": 7955, "disease": "X-linked nephrogenic diabetes insipidus (Disease Ontology:DOID:0081060); nephrogenic syndrome of inappropriate antidiuresis (Disease Ontology:DOID:0112121); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (dre:100151502)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001922042.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0045907 positive regulation of vasoconstriction;GO:0001992 regulation of systemic arterial blood pressure by vasopressin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QV55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RN56-1", "uniprot_id": "A0A8M1RN56_DANRE", "mass": 67876.0, "length": 606, "protein_name": "TBC1 domain family member 24", "gene_name": "tbc1d24", "organism": "Zebrafish", "refseq_name": "TBC1 domain family member 24 isoform X1", "refseq_ac": "XP_003201409", "gene_names_uniprotkb": "tbc1d24", "gene_names_refseq": "tbc1d24", "protein_names_uniprotkb": "TBC1 domain family member 24", "protein_names_refseq": "TBC1 domain family member 24 isoform X1", "tax_id": 7955, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); developmental and epileptic encephalopathy 16 (Disease Ontology:DOID:0080449); autosomal recessive nonsyndromic deafness 86 (Disease Ontology:DOID:0110532); autosomal dominant nonsyndromic deafness 65 (Disease Ontology:DOID:0110586); DOORS syndrome (Disease Ontology:DOID:0111627); Rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome (Disease Ontology:DOID:0111645); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dre:100536073)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_003201409.3. COMPLETENESS: full length., [RefSeq]; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse;GO:0012505 endomembrane system;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RN56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B737-1", "uniprot_id": "A0A8M2B737_DANRE", "mass": 83548.0, "length": 756, "protein_name": "Adhesion G protein-coupled receptor E3 isoform X1", "gene_name": "adgre5b.3", "organism": "Zebrafish", "refseq_name": "adhesion G protein-coupled receptor E3 isoform X1", "refseq_ac": "XP_005160275", "gene_names_uniprotkb": "adgre5b.3", "gene_names_refseq": "adgre5b.3", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor E3 isoform X1", "protein_names_refseq": "adhesion G protein-coupled receptor E3 isoform X1", "tax_id": 7955, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); vibratory urticaria (Disease Ontology:DOID:1554); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dre:792970)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0030855 epithelial cell differentiation;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RIU5-1", "uniprot_id": "A0A8M1RIU5_DANRE", "mass": 134859.0, "length": 1165, "protein_name": "Unconventional myosin-Ib", "gene_name": "myo1b", "organism": "Zebrafish", "refseq_name": "unconventional myosin-Ib isoform X1", "refseq_ac": "XP_003199241", "gene_names_uniprotkb": "myo1b", "gene_names_refseq": "myo1b", "protein_names_uniprotkb": "Unconventional myosin-Ib; Myosin I alpha", "protein_names_refseq": "unconventional myosin-Ib isoform X1", "tax_id": 7955, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dre:541515)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003199241.1. COMPLETENESS: full length., [RefSeq]; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GFY8", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005938 cell cortex;GO:0016459 myosin complex", "go_biological_process": "GO:0060576 intestinal epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RIU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1Z8-1", "uniprot_id": "A0A8M2B1Z8_DANRE", "mass": 142381.0, "length": 1300, "protein_name": "Contactin-associated protein-like 4 isoform X1", "gene_name": "cntnap3", "organism": "Zebrafish", "refseq_name": "contactin-associated protein-like 4 isoform X1", "refseq_ac": "XP_005155581", "gene_names_uniprotkb": "cntnap3", "gene_names_refseq": "cntnap3", "protein_names_uniprotkb": "Contactin-associated protein-like 4 isoform X1", "protein_names_refseq": "contactin-associated protein-like 4 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (dre:564195)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1Z8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B284-1", "uniprot_id": "A0A8M2B284_DANRE", "mass": 179876.0, "length": 1625, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1", "gene_name": "magi1b", "organism": "Zebrafish", "refseq_name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b isoform X1", "refseq_ac": "XP_005155886", "gene_names_uniprotkb": "magi1b; MAGI-1; baiap1; fe48b06; magi1; wu:fe48b06; wu:fj98f08", "gene_names_refseq": "MAGI-1; baiap1; fe48b06; magi1b; magi1; wu:fe48b06; wu:fj98f08", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; BAI1-associated protein 1; Membrane-associated guanylate kinase inverted 1", "protein_names_refseq": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:474349)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15509766;17606911;23676078;25294025;25417113;26253536;26469318;27189481;28252024;29180615", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QQU8-1", "uniprot_id": "A0A8M1QQU8_DANRE", "mass": 211980.0, "length": 1910, "protein_name": "Unconventional myosin-XVI isoform X1", "gene_name": "myo16", "organism": "Zebrafish", "refseq_name": "unconventional myosin-XVI isoform X1", "refseq_ac": "XP_001920958", "gene_names_uniprotkb": "myo16", "gene_names_refseq": "myo16", "protein_names_uniprotkb": "Unconventional myosin-XVI isoform X1", "protein_names_refseq": "unconventional myosin-XVI isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563752)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001920958.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0003774 cytoskeletal motor activity;GO:0051015 actin filament binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0016459 myosin complex;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048731 system development;GO:0048812 neuron projection morphogenesis;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QQU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RSR2-1", "uniprot_id": "A0A8M1RSR2_DANRE", "mass": 35356.0, "length": 321, "protein_name": "Cell surface glycoprotein CD200 receptor 1 isoform X1", "gene_name": "si:ch211-214p13.9", "organism": "Zebrafish", "refseq_name": "cell surface glycoprotein CD200 receptor 1 isoform X1", "refseq_ac": "XP_003199235", "gene_names_uniprotkb": "si:ch211-214p13.9", "gene_names_refseq": "si:ch211-214p13.9", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 1 isoform X1", "protein_names_refseq": "cell surface glycoprotein CD200 receptor 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100317238)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003199235.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RSR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B233-1", "uniprot_id": "A0A8M2B233_DANRE", "mass": 155173.0, "length": 1392, "protein_name": "Erbin isoform X1", "gene_name": "erbin", "organism": "Zebrafish", "refseq_name": "erbin isoform X1", "refseq_ac": "XP_005155633", "gene_names_uniprotkb": "erbin; erbb2ip; zgc:152984", "gene_names_refseq": "erbb2ip; erbin; zgc:152984", "protein_names_uniprotkb": "Erbin isoform X1", "protein_names_refseq": "erbin isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:566811)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21729873;26469318;27189481;28252024;29552291", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B233-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1Q9-1", "uniprot_id": "A0A8M2B1Q9_DANRE", "mass": 160844.0, "length": 1479, "protein_name": "Mitogen-activated protein kinase kinase kinase 1", "gene_name": "map3k1", "organism": "Zebrafish", "refseq_name": "mitogen-activated protein kinase kinase kinase 1 isoform X1", "refseq_ac": "XP_005155564", "gene_names_uniprotkb": "map3k1", "gene_names_refseq": "map3k1", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 1; MAPK/ERK kinase kinase 1", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 1 isoform X1", "tax_id": 7955, "disease": "diffuse gastric cancer (Disease Ontology:DOID:0080763); 46,XY sex reversal 6 (Disease Ontology:DOID:0111769); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:100334486)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005155564.1. COMPLETENESS: full length., [RefSeq]; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1Q9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RHF3-1", "uniprot_id": "A0A8M1RHF3_DANRE", "mass": 53347.0, "length": 481, "protein_name": "Metalloreductase STEAP3 isoform X1", "gene_name": "steap3", "organism": "Zebrafish", "refseq_name": "metalloreductase STEAP3 isoform X1", "refseq_ac": "XP_002663339", "gene_names_uniprotkb": "steap3", "gene_names_refseq": "steap3", "protein_names_uniprotkb": "Metalloreductase STEAP3 isoform X1", "protein_names_refseq": "metalloreductase STEAP3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100320152); (R-DRE-6803204); (R-DRE-9013148); (R-DRE-9013406); (R-DRE-9035034); (R-DRE-917977)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F9Y0;E9QHR0", "ec_number_list": "1.16.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0008823 cupric reductase (NADH) activity;GO:0052851 ferric-chelate reductase (NADPH) activity", "go_cellular_component": "GO:0010008 endosome membrane;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006826 iron ion transport;GO:0015677 copper ion import", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RHF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1M8-1", "uniprot_id": "A0A8M2B1M8_DANRE", "mass": 96934.0, "length": 877, "protein_name": "Very low-density lipoprotein receptor", "gene_name": "vldlr", "organism": "Zebrafish", "refseq_name": "very low-density lipoprotein receptor isoform X1", "refseq_ac": "XP_005155618", "gene_names_uniprotkb": "vldlr; zgc:55792", "gene_names_refseq": "vldlr; zgc:55792", "protein_names_uniprotkb": "Very low-density lipoprotein receptor", "protein_names_refseq": "very low-density lipoprotein receptor isoform X1", "tax_id": 7955, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1 (Disease Ontology:DOID:0070556); age related macular degeneration 1 (Disease Ontology:DOID:0110014); Alzheimer's disease (Disease Ontology:DOID:10652); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); autistic disorder (Disease Ontology:DOID:12849); dementia (Disease Ontology:DOID:1307); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (dre:393897)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;16109975;22364494;24613356;25217480;28252024;29429939;31323192;35110541;38660750", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0034185 apolipoprotein binding", "go_cellular_component": "GO:0005905 clathrin-coated pit;GO:0034361 very-low-density lipoprotein particle;GO:0005886 plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B1M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RRZ2-1", "uniprot_id": "A0A8M1RRZ2_DANRE", "mass": 36398.0, "length": 335, "protein_name": "Golgi reassembly-stacking protein 1b isoform X1", "gene_name": "gorasp1b", "organism": "Zebrafish", "refseq_name": "Golgi reassembly-stacking protein 1b isoform X1", "refseq_ac": "XP_002666782", "gene_names_uniprotkb": "gorasp1b; si:ch211-198c1.3; si:dkeyp-27g9.2", "gene_names_refseq": "gorasp1b; si:ch211-198c1.3; si:dkeyp-27g9.2", "protein_names_uniprotkb": "Golgi reassembly-stacking protein 1b isoform X1", "protein_names_refseq": "Golgi reassembly-stacking protein 1b isoform X1", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100330055)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002666782.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M1RRZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RL50-1", "uniprot_id": "A0A8M1RL50_DANRE", "mass": 54187.0, "length": 465, "protein_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase isoform X1", "gene_name": "si:dkey-96f10.1", "organism": "Zebrafish", "refseq_name": "si:dkey-96f10.1", "refseq_ac": "NP_001427711", "gene_names_uniprotkb": "si:dkey-96f10.1", "gene_names_refseq": "si:dkey-96f10.1", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase isoform X1", "protein_names_refseq": "si:dkey-96f10.1", "tax_id": 7955, "disease": "hyperinsulinism (Disease Ontology:DOID:2018)", "pathway": " (dre:100330415)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.4248207.1, SRR32588716.30606487.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On May 29, 2025 this sequence version replaced XP_002666487.2., [RefSeq]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0016874 ligase activity;GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RL50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6B7-1", "uniprot_id": "A0A8M2B6B7_DANRE", "mass": 24732.0, "length": 223, "protein_name": "Tumor protein D52 isoform X3", "gene_name": "tpd52", "organism": "Zebrafish", "refseq_name": "tumor protein D52 isoform X3", "refseq_ac": "XP_005159686", "gene_names_uniprotkb": "tpd52; si:ch211-203l9.2; si:ch211-203l9.3", "gene_names_refseq": "si:ch211-203l9.2; si:ch211-203l9.3; tpd52", "protein_names_uniprotkb": "Tumor protein D52 isoform X3", "protein_names_refseq": "tumor protein D52 isoform X3", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005159686.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1902035 positive regulation of hematopoietic stem cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B6B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7A1-1", "uniprot_id": "A0A8M2B7A1_DANRE", "mass": 61296.0, "length": 555, "protein_name": "Translation initiation factor eIF2B subunit delta", "gene_name": "eif2b4", "organism": "Zebrafish", "refseq_name": "translation initiation factor eIF2B subunit delta isoform X1", "refseq_ac": "XP_005160517", "gene_names_uniprotkb": "eif2b4; si:ch211-101l18.4; wu:fb54a09; zgc:110790", "gene_names_refseq": "eif2b4; si:ch211-101l18.4; wu:fb54a09; zgc:110790", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit delta; eIF2B GDP-GTP exchange factor subunit delta", "protein_names_refseq": "translation initiation factor eIF2B subunit delta isoform X1", "tax_id": 7955, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 4 (Disease Ontology:DOID:0070371)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0007417 central nervous system development;GO:0048513 animal organ development;GO:0002183 cytoplasmic translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B7A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5P2-1", "uniprot_id": "A0A8M2B5P2_DANRE", "mass": 91919.0, "length": 807, "protein_name": "Intron Large complex component GCFC2 isoform X1", "gene_name": "gcfc2", "organism": "Zebrafish", "refseq_name": "intron Large complex component GCFC2 isoform X1", "refseq_ac": "XP_005158788", "gene_names_uniprotkb": "gcfc2; zgc:171819", "gene_names_refseq": "gcfc2; zgc:171819", "protein_names_uniprotkb": "Intron Large complex component GCFC2 isoform X1", "protein_names_refseq": "intron Large complex component GCFC2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559280)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "26469318;28557307;32722765;34315984;38270285", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B5P2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2G5-1", "uniprot_id": "A0A8M2B2G5_DANRE", "mass": 115702.0, "length": 1015, "protein_name": "Kinesin-like protein KIF19", "gene_name": "kif19", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF19 isoform X1", "refseq_ac": "XP_005156460", "gene_names_uniprotkb": "kif19", "gene_names_refseq": "kif19", "protein_names_uniprotkb": "Kinesin-like protein KIF19", "protein_names_refseq": "kinesin-like protein KIF19 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565913)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0048731 system development;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RHY4-1", "uniprot_id": "A0A8M1RHY4_DANRE", "mass": 71051.0, "length": 617, "protein_name": "Proline dehydrogenase", "gene_name": "prodha", "organism": "Zebrafish", "refseq_name": "proline dehydrogenase 1, mitochondrial isoform X2", "refseq_ac": "XP_002665916", "gene_names_uniprotkb": "prodha", "gene_names_refseq": "prodha", "protein_names_uniprotkb": "Proline dehydrogenase; 1.5.5.2", "protein_names_refseq": "proline dehydrogenase 1, mitochondrial isoform X2", "tax_id": 7955, "disease": "schizophrenia 4 (Disease Ontology:DOID:0070080); hyperprolinemia type 1 (Disease Ontology:DOID:0080542); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (dre:100333321); (R-DRE-70688)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_002665916.3. COMPLETENESS: full length., [RefSeq]; Converts proline to delta-1-pyrroline-5-carboxylate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.5.2", "go_molecular_function": "GO:0071949 FAD binding;GO:0004657 proline dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate;GO:0006562 L-proline catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RHY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RDR2-1", "uniprot_id": "A0A8M1RDR2_DANRE", "mass": 66798.0, "length": 591, "protein_name": "Glutamate decarboxylase 1", "gene_name": "gad1a", "organism": "Zebrafish", "refseq_name": "glutamate decarboxylase 1 isoform X1", "refseq_ac": "XP_002663350", "gene_names_uniprotkb": "gad1a", "gene_names_refseq": "gad1a", "protein_names_uniprotkb": "Glutamate decarboxylase 1; 4.1.1.15", "protein_names_refseq": "glutamate decarboxylase 1 isoform X1", "tax_id": 7955, "disease": "spastic cerebral palsy (Disease Ontology:DOID:0050669); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 89 (Disease Ontology:DOID:0112223); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:100329827)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.15", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004351 glutamate decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0019752 carboxylic acid metabolic process;GO:0009449 gamma-aminobutyric acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RDR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B814-1", "uniprot_id": "A0A8M2B814_DANRE", "mass": 43532.0, "length": 385, "protein_name": "Glutamine synthetase", "gene_name": "glulc", "organism": "Zebrafish", "refseq_name": "glutamate-ammonia ligase (glutamine synthase) c isoform X1", "refseq_ac": "XP_005161169", "gene_names_uniprotkb": "glulc; zgc:152741", "gene_names_refseq": "glulc; zgc:152741", "protein_names_uniprotkb": "Glutamine synthetase; 6.3.1.2", "protein_names_refseq": "glutamate-ammonia ligase (glutamine synthase) c isoform X1", "tax_id": 7955, "disease": "amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005161169.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.1.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0016874 ligase activity;GO:0004356 glutamine synthetase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006542 glutamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RFQ9-1", "uniprot_id": "A0A8M1RFQ9_DANRE", "mass": 35713.0, "length": 309, "protein_name": "NEK6-subfamily protein kinase", "gene_name": "nek6", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase Nek6 isoform X1", "refseq_ac": "XP_003200870", "gene_names_uniprotkb": "nek6", "gene_names_refseq": "nek6", "protein_names_uniprotkb": "NEK6-subfamily protein kinase; 2.7.11.34", "protein_names_refseq": "serine/threonine-protein kinase Nek6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:497165)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200870.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RFQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QLR0-1", "uniprot_id": "A0A8M1QLR0_DANRE", "mass": 54542.0, "length": 477, "protein_name": "cyclin-dependent kinase", "gene_name": "cdk19", "organism": "Zebrafish", "refseq_name": "cyclin-dependent kinase 19 isoform X1", "refseq_ac": "XP_001923353", "gene_names_uniprotkb": "cdk19", "gene_names_refseq": "cdk19", "protein_names_uniprotkb": "cyclin-dependent kinase; 2.7.11.22", "protein_names_refseq": "cyclin-dependent kinase 19 isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 87 (Disease Ontology:DOID:0112221)", "pathway": " (dre:100149670)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001923353.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QKS1", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990508 CKM complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QLR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QQH6-1", "uniprot_id": "A0A8M1QQH6_DANRE", "mass": 156638.0, "length": 1382, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "ca16b", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase gamma", "refseq_ac": "XP_021332937", "gene_names_uniprotkb": "ca16b", "gene_names_refseq": "ca16b", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase gamma", "tax_id": 7955, "disease": "", "pathway": " (dre:569183)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QWY5", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QQH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QQZ8-1", "uniprot_id": "A0A8M1QQZ8_DANRE", "mass": 76070.0, "length": 690, "protein_name": "Solute carrier family 26 member 10", "gene_name": "slc26a10", "organism": "Zebrafish", "refseq_name": "solute carrier family 26 member 10", "refseq_ac": "XP_001921766", "gene_names_uniprotkb": "slc26a10", "gene_names_refseq": "slc26a10", "protein_names_uniprotkb": "Solute carrier family 26 member 10", "protein_names_refseq": "solute carrier family 26 member 10", "tax_id": 7955, "disease": "", "pathway": " (dre:100150270)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001921766.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FF67", "ec_number_list": "", "go_molecular_function": "GO:0015106 bicarbonate transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QQZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QUK8-1", "uniprot_id": "A0A8M1QUK8_DANRE", "mass": 76937.0, "length": 696, "protein_name": "Calcium-independent phospholipase A2-gamma isoform X1", "gene_name": "pnpla8", "organism": "Zebrafish", "refseq_name": "calcium-independent phospholipase A2-gamma isoform X1", "refseq_ac": "XP_001918731", "gene_names_uniprotkb": "pnpla8", "gene_names_refseq": "pnpla8", "protein_names_uniprotkb": "Calcium-independent phospholipase A2-gamma isoform X1", "protein_names_refseq": "calcium-independent phospholipase A2-gamma isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100126812)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_001918731.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004620 phospholipase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QUK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QUL5-1", "uniprot_id": "A0A8M1QUL5_DANRE", "mass": 108694.0, "length": 970, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "ksr1a", "organism": "Zebrafish", "refseq_name": "kinase suppressor of Ras 1 isoform X1", "refseq_ac": "XP_001919049", "gene_names_uniprotkb": "ksr1a", "gene_names_refseq": "ksr1a", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "kinase suppressor of Ras 1 isoform X1", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612); breast adenocarcinoma (Disease Ontology:DOID:3458)", "pathway": " (dre:100150814)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001919049.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QUL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QUN4-1", "uniprot_id": "A0A8M1QUN4_DANRE", "mass": 130729.0, "length": 1192, "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH4", "gene_name": "kcnh3", "organism": "Zebrafish", "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH8 isoform X1", "refseq_ac": "XP_001919436", "gene_names_uniprotkb": "kcnh3", "gene_names_refseq": "kcnh3", "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH4; Brain-specific eag-like channel 2; Ether-a-go-go-like potassium channel 1; Potassium voltage-gated channel subfamily H member 4; Voltage-gated potassium channel subunit Kv12.3", "protein_names_refseq": "voltage-gated delayed rectifier potassium channel KCNH8 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100006614)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001919436.2. COMPLETENESS: full length., [RefSeq]; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier. Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071805 potassium ion transmembrane transport;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QUN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QUT6-1", "uniprot_id": "A0A8M1QUT6_DANRE", "mass": 50714.0, "length": 461, "protein_name": "One cut domain family member", "gene_name": "onecut2", "organism": "Zebrafish", "refseq_name": "one cut domain family member 2 isoform X1", "refseq_ac": "XP_001920308", "gene_names_uniprotkb": "onecut2", "gene_names_refseq": "onecut2", "protein_names_uniprotkb": "One cut domain family member", "protein_names_refseq": "one cut domain family member 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100000073)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001920308.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QUT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QUZ1-1", "uniprot_id": "A0A8M1QUZ1_DANRE", "mass": 282121.0, "length": 2544, "protein_name": "Microtubule-associated protein 1A isoform X1", "gene_name": "map1aa", "organism": "Zebrafish", "refseq_name": "microtubule-associated protein 1A isoform X1", "refseq_ac": "XP_001921072", "gene_names_uniprotkb": "map1aa", "gene_names_refseq": "map1aa", "protein_names_uniprotkb": "Microtubule-associated protein 1A isoform X1", "protein_names_refseq": "microtubule-associated protein 1A isoform X1", "tax_id": 7955, "disease": "hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (dre:100151220)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001921072.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0000226 microtubule cytoskeleton organization;GO:0031114 regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1QUZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1QVB8-1", "uniprot_id": "A0A8M1QVB8_DANRE", "mass": 109899.0, "length": 956, "protein_name": "Aminopeptidase", "gene_name": "anpepla", "organism": "Zebrafish", "refseq_name": "aminopeptidase N isoform X1", "refseq_ac": "XP_001922987", "gene_names_uniprotkb": "anpepla", "gene_names_refseq": "anpepla", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "aminopeptidase N isoform X1", "tax_id": 7955, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (dre:555317)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_001922987.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1QVB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RDA8-1", "uniprot_id": "A0A8M1RDA8_DANRE", "mass": 23234.0, "length": 217, "protein_name": "Claudin", "gene_name": "cldn31", "organism": "Zebrafish", "refseq_name": "claudin-6", "refseq_ac": "XP_002660634", "gene_names_uniprotkb": "cldn31", "gene_names_refseq": "cldn31", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "claudin-6", "tax_id": 7955, "disease": "", "pathway": " (dre:100334365)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002660634.2. COMPLETENESS: full length., [RefSeq]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RDA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RDC6-1", "uniprot_id": "A0A8M1RDC6_DANRE", "mass": 33694.0, "length": 302, "protein_name": "Cathepsin Z", "gene_name": "LOC100333521", "organism": "Zebrafish", "refseq_name": "cathepsin Z", "refseq_ac": "XP_002661007", "gene_names_uniprotkb": "LOC100333521", "gene_names_refseq": "LOC100333521", "protein_names_uniprotkb": "Cathepsin Z; 3.4.18.1", "protein_names_refseq": "cathepsin Z", "tax_id": 7955, "disease": "", "pathway": " (dre:100333521)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002661007.2. COMPLETENESS: full length., [RefSeq]; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016807 cysteine-type carboxypeptidase activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RDC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RDF3-1", "uniprot_id": "A0A8M1RDF3_DANRE", "mass": 60839.0, "length": 551, "protein_name": "Intercellular adhesion molecule 1 isoform X1", "gene_name": "icam3", "organism": "Zebrafish", "refseq_name": "intercellular adhesion molecule 1 isoform X1", "refseq_ac": "XP_002661307", "gene_names_uniprotkb": "icam3", "gene_names_refseq": "icam3", "protein_names_uniprotkb": "Intercellular adhesion molecule 1 isoform X1", "protein_names_refseq": "intercellular adhesion molecule 1 isoform X1", "tax_id": 7955, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Prinzmetal angina (Disease Ontology:DOID:0111151); venous insufficiency (Disease Ontology:DOID:10128); aortic atherosclerosis (Disease Ontology:DOID:10230); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); allergic conjunctivitis (Disease Ontology:DOID:11204); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); mesenteric vascular occlusion (Disease Ontology:DOID:13252); biliary atresia (Disease Ontology:DOID:13608); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); brain edema (Disease Ontology:DOID:4724); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); localized scleroderma (Disease Ontology:DOID:8472); rheumatic myocarditis (Disease Ontology:DOID:8481); bullous pemphigoid (Disease Ontology:DOID:8506); chronic ulcer of skin (Disease Ontology:DOID:8549); Hodgkin's lymphoma (Disease Ontology:DOID:8567); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100334824)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002661307.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 87, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0060048 cardiac muscle contraction;GO:0055015 ventricular cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RDF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1Q3-1", "uniprot_id": "A0A8M2B1Q3_DANRE", "mass": 96303.0, "length": 902, "protein_name": "Zinc finger MIZ domain-containing protein 2 isoform X1", "gene_name": "zmiz2", "organism": "Zebrafish", "refseq_name": "zinc finger MIZ domain-containing protein 2 isoform X1", "refseq_ac": "XP_005155538", "gene_names_uniprotkb": "zmiz2", "gene_names_refseq": "zmiz2", "protein_names_uniprotkb": "Zinc finger MIZ domain-containing protein 2 isoform X1", "protein_names_refseq": "zinc finger MIZ domain-containing protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100333571)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IW44", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061665 SUMO ligase activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009953 dorsal/ventral pattern formation;GO:0007498 mesoderm development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1REB8-1", "uniprot_id": "A0A8M1REB8_DANRE", "mass": 95423.0, "length": 823, "protein_name": "AMP deaminase", "gene_name": "ampd2a", "organism": "Zebrafish", "refseq_name": "AMP deaminase 2 isoform X1", "refseq_ac": "XP_002666175", "gene_names_uniprotkb": "ampd2a", "gene_names_refseq": "ampd2a", "protein_names_uniprotkb": "AMP deaminase; 3.5.4.6", "protein_names_refseq": "AMP deaminase 2 isoform X1", "tax_id": 7955, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); pontocerebellar hypoplasia type 9 (Disease Ontology:DOID:0060278); hereditary spastic paraplegia 63 (Disease Ontology:DOID:0110814)", "pathway": " (dre:100330772)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002666175.2. COMPLETENESS: full length., [RefSeq]; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.6", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0097009 energy homeostasis;GO:0006188 IMP biosynthetic process;GO:0032264 IMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1REB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RED0-1", "uniprot_id": "A0A8M1RED0_DANRE", "mass": 91221.0, "length": 815, "protein_name": "Lethal(3)malignant brain tumor-like protein 1", "gene_name": "l3mbtl1a", "organism": "Zebrafish", "refseq_name": "lethal(3)malignant brain tumor-like protein 1 isoform X1", "refseq_ac": "XP_002666454", "gene_names_uniprotkb": "l3mbtl1a; l3mbtl1", "gene_names_refseq": "l3mbtl1", "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 1; L(3)mbt protein homolog", "protein_names_refseq": "lethal(3)malignant brain tumor-like protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002666454.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58INK9;A0AC58INN1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RED0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RER3-1", "uniprot_id": "A0A8M1RER3_DANRE", "mass": 41509.0, "length": 348, "protein_name": "Carbohydrate sulfotransferase", "gene_name": "chst12b.5", "organism": "Zebrafish", "refseq_name": "carbohydrate sulfotransferase 12-like", "refseq_ac": "XP_003197678", "gene_names_uniprotkb": "chst12b.5", "gene_names_refseq": "chst12b.5", "protein_names_uniprotkb": "Carbohydrate sulfotransferase; 2.8.2.-", "protein_names_refseq": "carbohydrate sulfotransferase 12-like", "tax_id": 7955, "disease": "", "pathway": " (dre:100538167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_003197678.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JG95", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RER3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RF06-1", "uniprot_id": "A0A8M1RF06_DANRE", "mass": 99102.0, "length": 873, "protein_name": "Heterogeneous nuclear ribonucleoprotein U-like protein 1", "gene_name": "hnrnpul1l", "organism": "Zebrafish", "refseq_name": "heterogeneous nuclear ribonucleoprotein U-like protein 1", "refseq_ac": "XP_003198760", "gene_names_uniprotkb": "hnrnpul1l", "gene_names_refseq": "hnrnpul1l", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein U-like protein 1", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein U-like protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100330645)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003198760.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0035989 tendon development;GO:0033339 pectoral fin development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RF06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RFA4-1", "uniprot_id": "A0A8M1RFA4_DANRE", "mass": 98804.0, "length": 881, "protein_name": "Semaphorin-4G", "gene_name": "sema4gb", "organism": "Zebrafish", "refseq_name": "semaphorin-4G", "refseq_ac": "XP_003199679", "gene_names_uniprotkb": "sema4gb", "gene_names_refseq": "sema4gb", "protein_names_uniprotkb": "Semaphorin-4G", "protein_names_refseq": "semaphorin-4G", "tax_id": 7955, "disease": "", "pathway": " (dre:100534852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003199679.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RFA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RFH9-1", "uniprot_id": "A0A8M1RFH9_DANRE", "mass": 194266.0, "length": 1703, "protein_name": "Kinesin-like protein KIF20B isoform X1", "gene_name": "kif20ba", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF20B isoform X1", "refseq_ac": "XP_003200393", "gene_names_uniprotkb": "kif20ba", "gene_names_refseq": "kif20ba", "protein_names_uniprotkb": "Kinesin-like protein KIF20B isoform X1", "protein_names_refseq": "kinesin-like protein KIF20B isoform X1", "tax_id": 7955, "disease": "microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dre:449979)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003200393.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0048731 system development;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RFH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RFK9-1", "uniprot_id": "A0A8M1RFK9_DANRE", "mass": 22374.0, "length": 205, "protein_name": "E3 ubiquitin-protein ligase RNF185", "gene_name": "rnf5", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF5", "refseq_ac": "XP_003200552", "gene_names_uniprotkb": "rnf5", "gene_names_refseq": "rnf5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF185; 2.3.2.27; RING finger protein 185", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF5", "tax_id": 7955, "disease": "", "pathway": " (dre:100537822)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0044390 ubiquitin-like protein conjugating enzyme binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RFK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RFX4-1", "uniprot_id": "A0A8M1RFX4_DANRE", "mass": 79214.0, "length": 726, "protein_name": "Leucine-rich repeat-containing protein 4B", "gene_name": "lrrc4bb", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat-containing protein 4B", "refseq_ac": "XP_003201401", "gene_names_uniprotkb": "lrrc4bb", "gene_names_refseq": "lrrc4bb", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4B", "protein_names_refseq": "leucine-rich repeat-containing protein 4B", "tax_id": 7955, "disease": "", "pathway": " (dre:100535350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E7F2A9", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RFX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RFY5-1", "uniprot_id": "A0A8M1RFY5_DANRE", "mass": 92301.0, "length": 807, "protein_name": "Uncharacterized protein si:ch73-170d6.2 isoform X1", "gene_name": "si:ch73-170d6.2", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:ch73-170d6.2 isoform X1", "refseq_ac": "XP_003201532", "gene_names_uniprotkb": "si:ch73-170d6.2", "gene_names_refseq": "si:ch73-170d6.2", "protein_names_uniprotkb": "Uncharacterized protein si:ch73-170d6.2 isoform X1", "protein_names_refseq": "uncharacterized protein si:ch73-170d6.2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:335285)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003201532.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IW29", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RFY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RHG3-1", "uniprot_id": "A0A8M1RHG3_DANRE", "mass": 86519.0, "length": 758, "protein_name": "Cyclic nucleotide-gated channel alpha-4 isoform X1", "gene_name": "cnga4", "organism": "Zebrafish", "refseq_name": "cyclic nucleotide-gated channel alpha-4 isoform X1", "refseq_ac": "XP_002663442", "gene_names_uniprotkb": "cnga4", "gene_names_refseq": "cnga4", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-4 isoform X1", "protein_names_refseq": "cyclic nucleotide-gated channel alpha-4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568123)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002663442.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex", "go_biological_process": "GO:0098655 monoatomic cation transmembrane transport;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RHG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RHH5-1", "uniprot_id": "A0A8M1RHH5_DANRE", "mass": 31831.0, "length": 270, "protein_name": "Phosphatidylinositol transfer protein alpha isoform", "gene_name": "pitpnab", "organism": "Zebrafish", "refseq_name": "phosphatidylinositol transfer protein alpha isoform", "refseq_ac": "XP_021335022", "gene_names_uniprotkb": "pitpnab", "gene_names_refseq": "pitpnab", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein alpha isoform", "protein_names_refseq": "phosphatidylinositol transfer protein alpha isoform", "tax_id": 7955, "disease": "chylomicron retention disease (Disease Ontology:DOID:0060357)", "pathway": " (dre:100333060)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8W544", "ec_number_list": "", "go_molecular_function": "GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity;GO:0008525 phosphatidylcholine transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RHH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RHN8-1", "uniprot_id": "A0A8M1RHN8_DANRE", "mass": 21944.0, "length": 194, "protein_name": "Refilin-B", "gene_name": "rflnb", "organism": "Zebrafish", "refseq_name": "refilin-B", "refseq_ac": "NP_001373214", "gene_names_uniprotkb": "rflnb; fam101b", "gene_names_refseq": "fam101b; rflnb", "protein_names_uniprotkb": "Refilin-B", "protein_names_refseq": "family with sequence similarity 101, member B; refilin-B", "tax_id": 7955, "disease": "", "pathway": " (dre:100286814)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22056673;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01007893.1, GDQQ01023725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000015.1. On or before Aug 18, 2020 this sequence version replaced XP_021330025.1, XP_002664671.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "X1WD14", "ec_number_list": "", "go_molecular_function": "GO:0031005 filamin binding", "go_cellular_component": "GO:0032432 actin filament bundle", "go_biological_process": "GO:1900158 negative regulation of bone mineralization involved in bone maturation;GO:0061572 actin filament bundle organization;GO:0048705 skeletal system morphogenesis;GO:0061182 negative regulation of chondrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M1RHN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RIB3-1", "uniprot_id": "A0A8M1RIB3_DANRE", "mass": 60745.0, "length": 547, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "stk39", "organism": "Zebrafish", "refseq_name": "STE20/SPS1-related proline-alanine-rich protein kinase", "refseq_ac": "XP_002667567", "gene_names_uniprotkb": "stk39", "gene_names_refseq": "stk39", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "STE20/SPS1-related proline-alanine-rich protein kinase", "tax_id": 7955, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (dre:100329854)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002667567.6. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010820 positive regulation of T cell chemotaxis;GO:0035556 intracellular signal transduction;GO:0071474 cellular hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RIB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RIG4-1", "uniprot_id": "A0A8M1RIG4_DANRE", "mass": 147130.0, "length": 1319, "protein_name": "Astrotactin-1 isoform X1", "gene_name": "astn1", "organism": "Zebrafish", "refseq_name": "astrotactin-1 isoform X1", "refseq_ac": "XP_003197930", "gene_names_uniprotkb": "astn1", "gene_names_refseq": "astn1", "protein_names_uniprotkb": "Astrotactin-1 isoform X1", "protein_names_refseq": "astrotactin-1 isoform X1", "tax_id": 7955, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:791157)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_003197930.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane", "go_biological_process": "GO:0001764 neuron migration;GO:0007158 neuron cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RIG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RIJ4-1", "uniprot_id": "A0A8M1RIJ4_DANRE", "mass": 21220.0, "length": 192, "protein_name": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "gene_name": "LOC100534952", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_003198167", "gene_names_uniprotkb": "LOC100534952", "gene_names_refseq": "LOC100534952", "protein_names_uniprotkb": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; 3.1.4.35", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100534952)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003198167.4. COMPLETENESS: full length., [RefSeq]; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.35", "go_molecular_function": "GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RIJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RIV5-1", "uniprot_id": "A0A8M1RIV5_DANRE", "mass": 89240.0, "length": 770, "protein_name": "Vitamin K-dependent gamma-carboxylase", "gene_name": "ggcx", "organism": "Zebrafish", "refseq_name": "vitamin K-dependent gamma-carboxylase", "refseq_ac": "XP_003199339", "gene_names_uniprotkb": "ggcx", "gene_names_refseq": "ggcx", "protein_names_uniprotkb": "Vitamin K-dependent gamma-carboxylase; 4.1.1.90; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase", "protein_names_refseq": "vitamin K-dependent gamma-carboxylase", "tax_id": 7955, "disease": "urolithiasis (Disease Ontology:DOID:0080653); combined deficiency of vitamin K-dependent clotting factors 1 (Disease Ontology:DOID:0112173)", "pathway": " (dre:557240)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_003199339.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.90", "go_molecular_function": "GO:0019842 vitamin binding;GO:0008488 gamma-glutamyl carboxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042373 vitamin K metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RIV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RJ11-1", "uniprot_id": "A0A8M1RJ11_DANRE", "mass": 45825.0, "length": 412, "protein_name": "D(1B) dopamine receptor", "gene_name": "drd5a", "organism": "Zebrafish", "refseq_name": "D(1B) dopamine receptor", "refseq_ac": "XP_003199815", "gene_names_uniprotkb": "drd5a", "gene_names_refseq": "drd5a", "protein_names_uniprotkb": "D(1B) dopamine receptor; D(5) dopamine receptor; Dopamine D5 receptor", "protein_names_refseq": "D(1B) dopamine receptor", "tax_id": 7955, "disease": "pervasive developmental disorder (Disease Ontology:DOID:0060040); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); blepharospasm (Disease Ontology:DOID:529)", "pathway": " (dre:100536970)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003199815.5. COMPLETENESS: full length., [RefSeq]; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RJ11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RJ67-1", "uniprot_id": "A0A8M1RJ67_DANRE", "mass": 27064.0, "length": 235, "protein_name": "Prepronociceptin", "gene_name": "pnoca", "organism": "Zebrafish", "refseq_name": "prepronociceptin", "refseq_ac": "XP_003200377", "gene_names_uniprotkb": "pnoca", "gene_names_refseq": "pnoca", "protein_names_uniprotkb": "Prepronociceptin", "protein_names_refseq": "prepronociceptin", "tax_id": 7955, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); cocaine abuse (Disease Ontology:DOID:809); neonatal abstinence syndrome (Disease Ontology:DOID:9828)", "pathway": " (dre:100529086)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200377.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031628 opioid receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007268 chemical synaptic transmission;GO:0007600 sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RJ67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RJF2-1", "uniprot_id": "A0A8M1RJF2_DANRE", "mass": 26475.0, "length": 233, "protein_name": "Ig-like domain-containing protein", "gene_name": "LOC795570", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_003200869", "gene_names_uniprotkb": "LOC795570", "gene_names_refseq": "LOC795570", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:795570)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200869.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RJF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RK31-1", "uniprot_id": "A0A8M1RK31_DANRE", "mass": 39653.0, "length": 365, "protein_name": "Heat shock protein beta-1", "gene_name": "si:dkey-1k23.3", "organism": "Zebrafish", "refseq_name": "heat shock protein beta-1", "refseq_ac": "XP_002662020", "gene_names_uniprotkb": "si:dkey-1k23.3", "gene_names_refseq": "si:dkey-1k23.3", "protein_names_uniprotkb": "Heat shock protein beta-1", "protein_names_refseq": "heat shock protein beta-1", "tax_id": 7955, "disease": "", "pathway": " (dre:100331249)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_002662020.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RK31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RKH6-1", "uniprot_id": "A0A8M1RKH6_DANRE", "mass": 26486.0, "length": 236, "protein_name": "Bax inhibitor 1", "gene_name": "tmbim6", "organism": "Zebrafish", "refseq_name": "bax inhibitor 1", "refseq_ac": "XP_002663718", "gene_names_uniprotkb": "tmbim6; tegt", "gene_names_refseq": "tegt", "protein_names_uniprotkb": "Bax inhibitor 1", "protein_names_refseq": "bax inhibitor 1", "tax_id": 7955, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); invasive ductal carcinoma (Disease Ontology:DOID:3008); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (dre:373123)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A140LGF6", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0060698 endoribonuclease inhibitor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:2001234 negative regulation of apoptotic signaling pathway;GO:0034620 cellular response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RKH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RKV1-1", "uniprot_id": "A0A8M1RKV1_DANRE", "mass": 98699.0, "length": 858, "protein_name": "Short transient receptor potential channel 6", "gene_name": "trpc6b", "organism": "Zebrafish", "refseq_name": "short transient receptor potential channel 6", "refseq_ac": "XP_002665445", "gene_names_uniprotkb": "trpc6b", "gene_names_refseq": "trpc6b", "protein_names_uniprotkb": "Short transient receptor potential channel 6", "protein_names_refseq": "short transient receptor potential channel 6", "tax_id": 7955, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); focal segmental glomerulosclerosis 2 (Disease Ontology:DOID:0111129); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); transient cerebral ischemia (Disease Ontology:DOID:224); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); chronic fatigue syndrome (Disease Ontology:DOID:8544); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dre:102725535)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002665445.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RKV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RLH0-1", "uniprot_id": "A0A8M1RLH0_DANRE", "mass": 55801.0, "length": 487, "protein_name": "Oxysterol-binding protein", "gene_name": "LOC100331149", "organism": "Zebrafish", "refseq_name": "oxysterol-binding protein-related protein 1 isoform X1", "refseq_ac": "XP_002667518", "gene_names_uniprotkb": "LOC100331149", "gene_names_refseq": "LOC100331149", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "oxysterol-binding protein-related protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100331149)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_002667518.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H8J6;A0AC58H8K5;A0AC58H8L0;A0AC58H8L8", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0005737 cytoplasm", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RLH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RLN2-1", "uniprot_id": "A0A8M1RLN2_DANRE", "mass": 145946.0, "length": 1331, "protein_name": "Calmodulin-regulated spectrin-associated protein 3 isoform X1", "gene_name": "LOC100007608", "organism": "Zebrafish", "refseq_name": "calmodulin-regulated spectrin-associated protein 3 isoform X1", "refseq_ac": "XP_003197845", "gene_names_uniprotkb": "LOC100007608", "gene_names_refseq": "LOC100007608", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 3 isoform X1", "protein_names_refseq": "calmodulin-regulated spectrin-associated protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100007608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0031175 neuron projection development;GO:0007026 negative regulation of microtubule depolymerization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RLN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RLN6-1", "uniprot_id": "A0A8M1RLN6_DANRE", "mass": 53854.0, "length": 485, "protein_name": "Fizzy-related protein homolog", "gene_name": "fzr1b", "organism": "Zebrafish", "refseq_name": "fizzy-related protein homolog isoform X1", "refseq_ac": "XP_003197866", "gene_names_uniprotkb": "fzr1b", "gene_names_refseq": "fzr1b", "protein_names_uniprotkb": "Fizzy-related protein homolog; Cdh1/Hct1 homolog", "protein_names_refseq": "fizzy-related protein homolog isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 109 (Disease Ontology:DOID:0070378); disease of cellular proliferation (Disease Ontology:DOID:14566)", "pathway": " (dre:100148604)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FF93", "ec_number_list": "", "go_molecular_function": "GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RLN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RLT2-1", "uniprot_id": "A0A8M1RLT2_DANRE", "mass": 72842.0, "length": 657, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "inpp5jb", "organism": "Zebrafish", "refseq_name": "inositol polyphosphate 5-phosphatase K", "refseq_ac": "XP_002662241", "gene_names_uniprotkb": "inpp5jb", "gene_names_refseq": "inpp5jb", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; 3.1.3.36; 3.1.3.56; Inositol polyphosphate 5-phosphatase J; Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase", "protein_names_refseq": "inositol polyphosphate 5-phosphatase K", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002662241.2. COMPLETENESS: full length., [RefSeq]; Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JMS0;A0AC58JMS7;A0AC58JMS9", "ec_number_list": "3.1.3.86;3.1.3.56;3.1.3.36", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0046030 inositol trisphosphate phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0001726 ruffle", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:0031115 negative regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RLT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RLU7-1", "uniprot_id": "A0A8M1RLU7_DANRE", "mass": 44491.0, "length": 394, "protein_name": "Gap junction protein", "gene_name": "si:dkey-91f15.8", "organism": "Zebrafish", "refseq_name": "gap junction gamma-1 protein-like isoform X1", "refseq_ac": "XP_002662449", "gene_names_uniprotkb": "si:dkey-91f15.8", "gene_names_refseq": "si:dkey-91f15.8", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "gap junction gamma-1 protein-like isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100334961)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002662449.3. COMPLETENESS: full length., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007154 cell communication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RLU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RLY1-1", "uniprot_id": "A0A8M1RLY1_DANRE", "mass": 26290.0, "length": 225, "protein_name": "THD domain-containing protein", "gene_name": "LOC100535208", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_003198686", "gene_names_uniprotkb": "LOC100535208", "gene_names_refseq": "LOC100535208", "protein_names_uniprotkb": "THD domain-containing protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100535208)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003198686.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RLY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RM30-1", "uniprot_id": "A0A8M1RM30_DANRE", "mass": 57369.0, "length": 508, "protein_name": "Cysteine-rich secretory protein LCCL domain-containing 2", "gene_name": "crispld2", "organism": "Zebrafish", "refseq_name": "cysteine-rich secretory protein LCCL domain-containing 2", "refseq_ac": "XP_003199065", "gene_names_uniprotkb": "crispld2", "gene_names_refseq": "crispld2", "protein_names_uniprotkb": "Cysteine-rich secretory protein LCCL domain-containing 2", "protein_names_refseq": "cysteine-rich secretory protein LCCL domain-containing 2", "tax_id": 7955, "disease": "orofacial cleft (Disease Ontology:DOID:0050567)", "pathway": " (dre:100535149)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060021 roof of mouth development;GO:0060325 face morphogenesis;GO:0060536 cartilage morphogenesis;GO:0048703 embryonic viscerocranium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RM30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RM42-1", "uniprot_id": "A0A8M1RM42_DANRE", "mass": 62694.0, "length": 573, "protein_name": "Dihydropyrimidinase-related protein 2", "gene_name": "dpysl2a", "organism": "Zebrafish", "refseq_name": "dihydropyrimidinase-related protein 2", "refseq_ac": "XP_003199094", "gene_names_uniprotkb": "dpysl2a", "gene_names_refseq": "dpysl2a", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 2", "protein_names_refseq": "dihydropyrimidinase-related protein 2", "tax_id": 7955, "disease": "hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (dre:798555)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "go_cellular_component": "GO:0005829 cytosol;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RM42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RM49-1", "uniprot_id": "A0A8M1RM49_DANRE", "mass": 108716.0, "length": 981, "protein_name": "Uncharacterized protein zhx3a", "gene_name": "zhx3a", "organism": "Zebrafish", "refseq_name": "uncharacterized protein zhx3a", "refseq_ac": "XP_002663833", "gene_names_uniprotkb": "zhx3a", "gene_names_refseq": "zhx3a", "protein_names_uniprotkb": "Uncharacterized protein zhx3a", "protein_names_refseq": "uncharacterized protein zhx3a", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002663833.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GT01;A0AC58GT10;E7EY09", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RM49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMD1-1", "uniprot_id": "A0A8M1RMD1_DANRE", "mass": 105850.0, "length": 936, "protein_name": "Nucleotide-binding oligomerization domain-containing protein 1 isoform X1", "gene_name": "nod1", "organism": "Zebrafish", "refseq_name": "nucleotide-binding oligomerization domain-containing protein 1 isoform X1", "refseq_ac": "XP_002665106", "gene_names_uniprotkb": "nod1", "gene_names_refseq": "nod1", "protein_names_uniprotkb": "Nucleotide-binding oligomerization domain-containing protein 1 isoform X1", "protein_names_refseq": "nucleotide-binding oligomerization domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (dre:100330810)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002665106.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0050700 CARD domain binding;GO:0038187 pattern recognition receptor activity;GO:1900750 oligopeptide binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMI4-1", "uniprot_id": "A0A8M1RMI4_DANRE", "mass": 121653.0, "length": 1098, "protein_name": "Integrin alpha-E", "gene_name": "itgae.2", "organism": "Zebrafish", "refseq_name": "integrin alpha-E", "refseq_ac": "XP_003200076", "gene_names_uniprotkb": "itgae.2", "gene_names_refseq": "itgae.2", "protein_names_uniprotkb": "Integrin alpha-E", "protein_names_refseq": "integrin alpha-E", "tax_id": 7955, "disease": "", "pathway": " (dre:100536705)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200076.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0008305 integrin complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMJ8-1", "uniprot_id": "A0A8M1RMJ8_DANRE", "mass": 75042.0, "length": 659, "protein_name": "Dihydroxyacetone phosphate acyltransferase isoform X1", "gene_name": "gnpat2", "organism": "Zebrafish", "refseq_name": "dihydroxyacetone phosphate acyltransferase isoform X1", "refseq_ac": "XP_002665823", "gene_names_uniprotkb": "gnpat2", "gene_names_refseq": "gnpat2", "protein_names_uniprotkb": "Dihydroxyacetone phosphate acyltransferase isoform X1", "protein_names_refseq": "dihydroxyacetone phosphate acyltransferase isoform X1", "tax_id": 7955, "disease": "rhizomelic chondrodysplasia punctata type 2 (Disease Ontology:DOID:0110852); disease of mental health (Disease Ontology:DOID:150)", "pathway": " (dre:336430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002665823.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016287 glycerone-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMK1-1", "uniprot_id": "A0A8M1RMK1_DANRE", "mass": 290042.0, "length": 2633, "protein_name": "Apolipoprotein B-100", "gene_name": "apobb.2", "organism": "Zebrafish", "refseq_name": "apolipoprotein B-100", "refseq_ac": "XP_002665852", "gene_names_uniprotkb": "apobb.2", "gene_names_refseq": "apobb.2", "protein_names_uniprotkb": "Apolipoprotein B-100", "protein_names_refseq": "apolipoprotein B-100", "tax_id": 7955, "disease": "familial hypobetalipoproteinemia 2 (Disease Ontology:DOID:0111061); familial hypobetalipoproteinemia 1 (Disease Ontology:DOID:0111062); sickle cell anemia (Disease Ontology:DOID:10923); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); beta thalassemia (Disease Ontology:DOID:12241); cardiovascular system disease (Disease Ontology:DOID:1287); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390); aortic valve stenosis (Disease Ontology:DOID:1712); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); gallbladder cancer (Disease Ontology:DOID:3121); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); bile duct cancer (Disease Ontology:DOID:4606); biliary tract cancer (Disease Ontology:DOID:4607); common bile duct neoplasm (Disease Ontology:DOID:4608); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100330435)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002665852.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0034361 very-low-density lipoprotein particle;GO:0034362 low-density lipoprotein particle;GO:0034359 mature chylomicron", "go_biological_process": "GO:0042953 lipoprotein transport;GO:0042632 cholesterol homeostasis;GO:0030301 cholesterol transport;GO:0006642 triglyceride mobilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1RMK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMK2-1", "uniprot_id": "A0A8M1RMK2_DANRE", "mass": 130253.0, "length": 1170, "protein_name": "Integrin alpha-10", "gene_name": "itga10", "organism": "Zebrafish", "refseq_name": "integrin alpha-10", "refseq_ac": "XP_003200204", "gene_names_uniprotkb": "itga10", "gene_names_refseq": "itga10", "protein_names_uniprotkb": "Integrin alpha-10", "protein_names_refseq": "integrin alpha-10", "tax_id": 7955, "disease": "", "pathway": " (dre:572348)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003200204.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0034680 integrin alpha10-beta1 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M1RMK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMM6-1", "uniprot_id": "A0A8M1RMM6_DANRE", "mass": 46597.0, "length": 403, "protein_name": "Serine/threonine-protein kinase 32B", "gene_name": "stk32a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase 32B", "refseq_ac": "XP_002666127", "gene_names_uniprotkb": "stk32a", "gene_names_refseq": "stk32a", "protein_names_uniprotkb": "Serine/threonine-protein kinase 32B", "protein_names_refseq": "serine/threonine-protein kinase 32B", "tax_id": 7955, "disease": "", "pathway": " (dre:100330817)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002666127.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMN7-1", "uniprot_id": "A0A8M1RMN7_DANRE", "mass": 91493.0, "length": 803, "protein_name": "ATP-dependent RNA helicase", "gene_name": "ddx24", "organism": "Zebrafish", "refseq_name": "ATP-dependent RNA helicase DDX24", "refseq_ac": "XP_003200454", "gene_names_uniprotkb": "ddx24", "gene_names_refseq": "ddx24", "protein_names_uniprotkb": "ATP-dependent RNA helicase; 3.6.4.13", "protein_names_refseq": "ATP-dependent RNA helicase DDX24", "tax_id": 7955, "disease": "", "pathway": " (dre:553462)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200454.1. COMPLETENESS: full length., [RefSeq]; ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA., [UniProtKB, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMQ4-1", "uniprot_id": "A0A8M1RMQ4_DANRE", "mass": 85712.0, "length": 783, "protein_name": "Delta-like protein", "gene_name": "LOC100535882", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_003200521", "gene_names_uniprotkb": "LOC100535882", "gene_names_refseq": "LOC100535882", "protein_names_uniprotkb": "Delta-like protein", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100535882)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200521.1. COMPLETENESS: full length., [RefSeq]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0007417 central nervous system development;GO:0048666 neuron development;GO:0048568 embryonic organ development;GO:0031017 exocrine pancreas development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMT9-1", "uniprot_id": "A0A8M1RMT9_DANRE", "mass": 97979.0, "length": 889, "protein_name": "Protein phosphatase 1 regulatory subunit", "gene_name": "zmp:0000001167", "organism": "Zebrafish", "refseq_name": "protein phosphatase 1 regulatory subunit 12A isoform X1", "refseq_ac": "XP_002666820", "gene_names_uniprotkb": "zmp:0000001167", "gene_names_refseq": "zmp:0000001167", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 12A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:571837)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002666820.2. COMPLETENESS: full length., [RefSeq]; Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007165 signal transduction;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RMY1-1", "uniprot_id": "A0A8M1RMY1_DANRE", "mass": 102176.0, "length": 914, "protein_name": "BRCA1-A complex subunit RAP80", "gene_name": "uimc1", "organism": "Zebrafish", "refseq_name": "BRCA1-A complex subunit RAP80", "refseq_ac": "XP_003200939", "gene_names_uniprotkb": "uimc1", "gene_names_refseq": "uimc1", "protein_names_uniprotkb": "BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1", "protein_names_refseq": "BRCA1-A complex subunit RAP80", "tax_id": 7955, "disease": "", "pathway": " (dre:100535018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003200939.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0006302 double-strand break repair;GO:0045739 positive regulation of DNA repair;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RMY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RN91-1", "uniprot_id": "A0A8M1RN91_DANRE", "mass": 63296.0, "length": 556, "protein_name": "Tripartite motif-containing protein 16", "gene_name": "ftr36", "organism": "Zebrafish", "refseq_name": "tripartite motif-containing protein 16", "refseq_ac": "XP_003198037", "gene_names_uniprotkb": "ftr36", "gene_names_refseq": "ftr36", "protein_names_uniprotkb": "Tripartite motif-containing protein 16", "protein_names_refseq": "tripartite motif-containing protein 16", "tax_id": 7955, "disease": "", "pathway": " (dre:100126118)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RN91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RNJ3-1", "uniprot_id": "A0A8M1RNJ3_DANRE", "mass": 66652.0, "length": 596, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC100536890", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_001342181", "gene_names_uniprotkb": "LOC100536890; LOC100002381", "gene_names_refseq": "LOC100002381", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100002381); (dre:100536890)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_001342181.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RNJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RNM4-1", "uniprot_id": "A0A8M1RNM4_DANRE", "mass": 69577.0, "length": 618, "protein_name": "long-chain-fatty-acid--CoA ligase", "gene_name": "LOC568883", "organism": "Zebrafish", "refseq_name": "long-chain fatty acid transport protein 6", "refseq_ac": "XP_003199367", "gene_names_uniprotkb": "LOC568883", "gene_names_refseq": "LOC568883", "protein_names_uniprotkb": "long-chain-fatty-acid--CoA ligase; 6.2.1.3; Long-chain-fatty-acid--CoA ligase", "protein_names_refseq": "long-chain fatty acid transport protein 6", "tax_id": 7955, "disease": "", "pathway": " (dre:568883)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_003199367.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;6.2.1.15", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0044539 long-chain fatty acid import into cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RNM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RNN7-1", "uniprot_id": "A0A8M1RNN7_DANRE", "mass": 149009.0, "length": 1348, "protein_name": "Bile salt export pump", "gene_name": "abcb11b", "organism": "Zebrafish", "refseq_name": "bile salt export pump isoform X1", "refseq_ac": "XP_003199513", "gene_names_uniprotkb": "abcb11b", "gene_names_refseq": "abcb11b", "protein_names_uniprotkb": "Bile salt export pump", "protein_names_refseq": "bile salt export pump isoform X1", "tax_id": 7955, "disease": "progressive familial intrahepatic cholestasis 2 (Disease Ontology:DOID:0070222); benign recurrent intrahepatic cholestasis 2 (Disease Ontology:DOID:0070232); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); intrahepatic cholestasis (Disease Ontology:DOID:1852); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (dre:571189)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003199513.2. COMPLETENESS: full length., [RefSeq]; Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0015126 canalicular bile acid transmembrane transporter activity;GO:0015432 ABC-type bile acid transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015722 canalicular bile acid transport;GO:0032782 bile acid secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RNN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RNU2-1", "uniprot_id": "A0A8M1RNU2_DANRE", "mass": 48233.0, "length": 423, "protein_name": "E3 ubiquitin-protein ligase RNF14", "gene_name": "LOC100537178", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF14-like", "refseq_ac": "XP_003200050", "gene_names_uniprotkb": "LOC100537178", "gene_names_refseq": "LOC100537178", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF14; 2.3.2.31; RING finger protein 14", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF14-like", "tax_id": 7955, "disease": "", "pathway": " (dre:100537178)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_003200050.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RNU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RP38-1", "uniprot_id": "A0A8M1RP38_DANRE", "mass": 622147.0, "length": 5527, "protein_name": "Midasin", "gene_name": "mdn1", "organism": "Zebrafish", "refseq_name": "midasin", "refseq_ac": "XP_003200751", "gene_names_uniprotkb": "mdn1", "gene_names_refseq": "mdn1", "protein_names_uniprotkb": "Midasin", "protein_names_refseq": "midasin", "tax_id": 7955, "disease": "", "pathway": " (dre:555704)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200751.1. COMPLETENESS: full length., [RefSeq]; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RP38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RP57-1", "uniprot_id": "A0A8M1RP57_DANRE", "mass": 56542.0, "length": 508, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC100534990", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase pim-2-like", "refseq_ac": "XP_003200861", "gene_names_uniprotkb": "LOC100534990", "gene_names_refseq": "LOC100534990", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase pim-2-like", "tax_id": 7955, "disease": "", "pathway": " (dre:100534990)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_003200861.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RP57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RP87-1", "uniprot_id": "A0A8M1RP87_DANRE", "mass": 207391.0, "length": 1860, "protein_name": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1", "gene_name": "cpamd8", "organism": "Zebrafish", "refseq_name": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1", "refseq_ac": "XP_003201105", "gene_names_uniprotkb": "cpamd8", "gene_names_refseq": "cpamd8", "protein_names_uniprotkb": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1", "protein_names_refseq": "C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 isoform X1", "tax_id": 7955, "disease": "anterior segment dysgenesis (Disease Ontology:DOID:0060648); anterior segment dysgenesis 8 (Disease Ontology:DOID:0080613)", "pathway": " (dre:100151400)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003201105.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007399 nervous system development;GO:0030199 collagen fibril organization;GO:0048593 camera-type eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RP87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RPE6-1", "uniprot_id": "A0A8M1RPE6_DANRE", "mass": 22307.0, "length": 205, "protein_name": "Uncharacterized protein hspb12", "gene_name": "hspb12", "organism": "Zebrafish", "refseq_name": "uncharacterized protein hspb12", "refseq_ac": "XP_003201762", "gene_names_uniprotkb": "hspb12", "gene_names_refseq": "hspb12", "protein_names_uniprotkb": "Uncharacterized protein hspb12", "protein_names_refseq": "uncharacterized protein hspb12", "tax_id": 7955, "disease": "", "pathway": " (dre:324021)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003201762.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0061371 determination of heart left/right asymmetry;GO:0071907 determination of digestive tract left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RPE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RQT0-1", "uniprot_id": "A0A8M1RQT0_DANRE", "mass": 116180.0, "length": 1008, "protein_name": "Anoctamin", "gene_name": "ano8a", "organism": "Zebrafish", "refseq_name": "anoctamin-8", "refseq_ac": "XP_002660858", "gene_names_uniprotkb": "ano8a", "gene_names_refseq": "ano8a", "protein_names_uniprotkb": "Anoctamin", "protein_names_refseq": "anoctamin-8", "tax_id": 7955, "disease": "", "pathway": " (dre:562947)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RQT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RQY7-1", "uniprot_id": "A0A8M1RQY7_DANRE", "mass": 144086.0, "length": 1308, "protein_name": "KN motif and ankyrin repeat domain-containing protein 1a", "gene_name": "kank1a", "organism": "Zebrafish", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 1a", "refseq_ac": "NP_001352186", "gene_names_uniprotkb": "kank1a; kank1; si:dkey-146l2.1; wu:fc93h12; zgc:153166", "gene_names_refseq": "fc93h12; kank1a; kank1; si:dkey-146l2.1; wu:fc93h12; zgc:153166", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 1a", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 1a; KN motif and ankyrin repeat domains 1; ankrd15", "tax_id": 7955, "disease": "spastic quadriplegic cerebral palsy 2 (Disease Ontology:DOID:0081360); cancer (Disease Ontology:DOID:162); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:777729)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15520368;22286130;22387208;22749781;26469318;26745549;27189481;27292017;28067315;35079792", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395039.94539.1, SRR32588734.3467803.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505377, SAMEA3505382 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001352186.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QCJ6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M1RQY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RQZ6-1", "uniprot_id": "A0A8M1RQZ6_DANRE", "mass": 40188.0, "length": 360, "protein_name": "Protein Wnt", "gene_name": "wnt6a", "organism": "Zebrafish", "refseq_name": "protein Wnt-6", "refseq_ac": "XP_002662357", "gene_names_uniprotkb": "wnt6a", "gene_names_refseq": "wnt6a", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-6", "tax_id": 7955, "disease": "", "pathway": " (dre:100332722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 1, 2013 this sequence version replaced XP_002662357.2. COMPLETENESS: full length., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030182 neuron differentiation;GO:0060070 canonical Wnt signaling pathway;GO:0048513 animal organ development;GO:0045165 cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RQZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RRA7-1", "uniprot_id": "A0A8M1RRA7_DANRE", "mass": 49316.0, "length": 438, "protein_name": "Calcium/calmodulin-dependent protein kinase type IV", "gene_name": "si:ch73-60h1.1", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase type IV", "refseq_ac": "XP_021335442", "gene_names_uniprotkb": "si:ch73-60h1.1", "gene_names_refseq": "si:ch73-60h1.1", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type IV; 2.7.11.17; CaM kinase-GR", "protein_names_refseq": "calcium/calmodulin-dependent protein kinase type IV", "tax_id": 7955, "disease": "", "pathway": " (dre:100332381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FEG8", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RRA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RRC7-1", "uniprot_id": "A0A8M1RRC7_DANRE", "mass": 32302.0, "length": 286, "protein_name": "Phospholipid phosphatase 4", "gene_name": "plpp4", "organism": "Zebrafish", "refseq_name": "phospholipid phosphatase 4", "refseq_ac": "XP_002664129", "gene_names_uniprotkb": "plpp4", "gene_names_refseq": "plpp4", "protein_names_uniprotkb": "Phospholipid phosphatase 4", "protein_names_refseq": "phospholipid phosphatase 4", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (dre:100334794)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_002664129.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RRC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RRD3-1", "uniprot_id": "A0A8M1RRD3_DANRE", "mass": 113352.0, "length": 1005, "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH5", "gene_name": "kcnh5b", "organism": "Zebrafish", "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH5", "refseq_ac": "XP_002664253", "gene_names_uniprotkb": "kcnh5b", "gene_names_refseq": "kcnh5b", "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH5", "protein_names_refseq": "voltage-gated delayed rectifier potassium channel KCNH5", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:100331767)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RRD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RRU8-1", "uniprot_id": "A0A8M1RRU8_DANRE", "mass": 22089.0, "length": 192, "protein_name": "Guanylyl cyclase-activating protein 1", "gene_name": "guca1ab.2", "organism": "Zebrafish", "refseq_name": "guanylyl cyclase-activating protein 1", "refseq_ac": "XP_002666176", "gene_names_uniprotkb": "guca1ab.2", "gene_names_refseq": "guca1ab.2", "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 1; Guanylate cyclase activator 1A", "protein_names_refseq": "guanylyl cyclase-activating protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:100330921)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0001917 photoreceptor inner segment;GO:0120199 cone photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RRU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RRX4-1", "uniprot_id": "A0A8M1RRX4_DANRE", "mass": 38245.0, "length": 330, "protein_name": "C-C chemokine receptor type 2 isoform X1", "gene_name": "ccr12b.2", "organism": "Zebrafish", "refseq_name": "C-C chemokine receptor type 2 isoform X1", "refseq_ac": "XP_002666623", "gene_names_uniprotkb": "ccr12b.2", "gene_names_refseq": "ccr12b.2", "protein_names_uniprotkb": "C-C chemokine receptor type 2 isoform X1", "protein_names_refseq": "C-C chemokine receptor type 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568139)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_002666623.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RRX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RS57-1", "uniprot_id": "A0A8M1RS57_DANRE", "mass": 49549.0, "length": 433, "protein_name": "E3 ubiquitin-protein ligase RNF14", "gene_name": "LOC100333926", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF14-like", "refseq_ac": "XP_002667383", "gene_names_uniprotkb": "LOC100333926", "gene_names_refseq": "LOC100333926", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF14; 2.3.2.31; RING finger protein 14", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF14-like", "tax_id": 7955, "disease": "", "pathway": " (dre:100333926)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_002667383.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RS57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RS78-1", "uniprot_id": "A0A8M1RS78_DANRE", "mass": 104886.0, "length": 942, "protein_name": "Myelin regulatory factor", "gene_name": "myrfl", "organism": "Zebrafish", "refseq_name": "myelin regulatory factor-like protein isoform X1", "refseq_ac": "XP_002667695", "gene_names_uniprotkb": "myrfl", "gene_names_refseq": "myrfl", "protein_names_uniprotkb": "Myelin regulatory factor; Myelin gene regulatory factor", "protein_names_refseq": "myelin regulatory factor-like protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100329855)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_002667695.3. COMPLETENESS: full length., [RefSeq]; Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes., [UniProtKB, UniProtKB]; Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060429 epithelium development;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RS78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RS83-1", "uniprot_id": "A0A8M1RS83_DANRE", "mass": 122761.0, "length": 1097, "protein_name": "Phosphoinositide phospholipase C", "gene_name": "plcl2", "organism": "Zebrafish", "refseq_name": "inactive phospholipase C-like protein 2 isoform X1", "refseq_ac": "XP_002667725", "gene_names_uniprotkb": "plcl2", "gene_names_refseq": "plcl2", "protein_names_uniprotkb": "Phosphoinositide phospholipase C; 3.1.4.11", "protein_names_refseq": "inactive phospholipase C-like protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100334276)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_002667725.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HLJ2", "ec_number_list": "3.1.4.11", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0016042 lipid catabolic process;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RS83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RSA0-1", "uniprot_id": "A0A8M1RSA0_DANRE", "mass": 165123.0, "length": 1472, "protein_name": "HECT-type E3 ubiquitin transferase", "gene_name": "hecw2b", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase HECW2", "refseq_ac": "XP_003197660", "gene_names_uniprotkb": "hecw2b", "gene_names_refseq": "hecw2b", "protein_names_uniprotkb": "HECT-type E3 ubiquitin transferase; 2.3.2.26", "protein_names_refseq": "E3 ubiquitin-protein ligase HECW2", "tax_id": 7955, "disease": "", "pathway": " (dre:100331355)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_003197660.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RSA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RT66-1", "uniprot_id": "A0A8M1RT66_DANRE", "mass": 60756.0, "length": 537, "protein_name": "Neuropilin and tolloid-like protein 2 isoform X1", "gene_name": "neto2b", "organism": "Zebrafish", "refseq_name": "neuropilin and tolloid-like protein 2 isoform X1", "refseq_ac": "XP_021323426", "gene_names_uniprotkb": "neto2b", "gene_names_refseq": "neto2b", "protein_names_uniprotkb": "Neuropilin and tolloid-like protein 2 isoform X1", "protein_names_refseq": "neuropilin and tolloid-like protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100034584)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RT66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RTH6-1", "uniprot_id": "A0A8M1RTH6_DANRE", "mass": 131837.0, "length": 1174, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "atp8b3", "organism": "Zebrafish", "refseq_name": "phospholipid-transporting ATPase IC isoform X1", "refseq_ac": "XP_003201102", "gene_names_uniprotkb": "atp8b3", "gene_names_refseq": "atp8b3", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase IC isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:566530)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_003201102.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RTH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M1RTP2-1", "uniprot_id": "A0A8M1RTP2_DANRE", "mass": 40437.0, "length": 367, "protein_name": "lysozyme", "gene_name": "LOC100536887", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_003201752", "gene_names_uniprotkb": "LOC100536887", "gene_names_refseq": "LOC100536887", "protein_names_uniprotkb": "lysozyme; 3.2.1.17", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:100536887)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M1RTP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1M0-1", "uniprot_id": "A0A8M2B1M0_DANRE", "mass": 48149.0, "length": 442, "protein_name": "Cell adhesion molecule 2a isoform X1", "gene_name": "cadm2a", "organism": "Zebrafish", "refseq_name": "cell adhesion molecule 2a isoform X1", "refseq_ac": "XP_005155320", "gene_names_uniprotkb": "cadm2a; igsf4d; zgc:66339", "gene_names_refseq": "cadm2a; igsf4d; zgc:66339", "protein_names_uniprotkb": "Cell adhesion molecule 2a isoform X1", "protein_names_refseq": "cell adhesion molecule 2a isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); malignant astrocytoma (Disease Ontology:DOID:3069); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1N3-1", "uniprot_id": "A0A8M2B1N3_DANRE", "mass": 174862.0, "length": 1563, "protein_name": "Histone-lysine N-methyltransferase NSD3", "gene_name": "nsd3", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase NSD3 isoform X1", "refseq_ac": "XP_073770731", "gene_names_uniprotkb": "nsd3", "gene_names_refseq": "nsd3", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase NSD3; 2.1.1.370; 2.1.1.371; Nuclear SET domain-containing protein 3", "protein_names_refseq": "histone-lysine N-methyltransferase NSD3 isoform X1", "tax_id": 7955, "disease": "Sotos syndrome 1 (Disease Ontology:DOID:0112103); syndrome (Disease Ontology:DOID:225); myeloid leukemia (Disease Ontology:DOID:8692)", "pathway": " (dre:100006350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GLW5", "ec_number_list": "2.1.1.370;2.1.1.371", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140946 histone H3K4 dimethyltransferase activity;GO:0140952 histone H3K27 dimethyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1S8-1", "uniprot_id": "A0A8M2B1S8_DANRE", "mass": 16224.0, "length": 146, "protein_name": "Endothelin-3", "gene_name": "edn3a", "organism": "Zebrafish", "refseq_name": "endothelin-1", "refseq_ac": "XP_005155737", "gene_names_uniprotkb": "edn3a; LOC101884385", "gene_names_refseq": "LOC101884385", "protein_names_uniprotkb": "Endothelin-3; Preproendothelin-3", "protein_names_refseq": "endothelin-1", "tax_id": 7955, "disease": "", "pathway": " (dre:101884385)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Endothelins are endothelium-derived vasoconstrictor peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0031708 endothelin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045987 positive regulation of smooth muscle contraction;GO:0006874 intracellular calcium ion homeostasis;GO:0019229 regulation of vasoconstriction;GO:0003100 regulation of systemic arterial blood pressure by endothelin;GO:0014826 vein smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1T7-1", "uniprot_id": "A0A8M2B1T7_DANRE", "mass": 49970.0, "length": 444, "protein_name": "Serine/threonine-protein kinase NIM1", "gene_name": "LOC559131", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase NIM1 isoform 1", "refseq_ac": "NP_001427654", "gene_names_uniprotkb": "LOC559131", "gene_names_refseq": "LOC559131", "protein_names_uniprotkb": "Serine/threonine-protein kinase NIM1; 2.7.11.1; NIM1 serine/threonine-protein kinase", "protein_names_refseq": "serine/threonine-protein kinase NIM1 isoform 1", "tax_id": 7955, "disease": "", "pathway": " (dre:559131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.24903837.1, SRR32588732.5397508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476788, SAMN01765705 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000011.1. On May 27, 2025 this sequence version replaced XP_005155766.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0050321 tau-protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B1X5-1", "uniprot_id": "A0A8M2B1X5_DANRE", "mass": 167504.0, "length": 1470, "protein_name": "Secretory phospholipase A2 receptor", "gene_name": "pla2r1", "organism": "Zebrafish", "refseq_name": "secretory phospholipase A2 receptor", "refseq_ac": "XP_005155783", "gene_names_uniprotkb": "pla2r1", "gene_names_refseq": "pla2r1", "protein_names_uniprotkb": "Secretory phospholipase A2 receptor", "protein_names_refseq": "secretory phospholipase A2 receptor", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GRY0", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B1X5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B247-1", "uniprot_id": "A0A8M2B247_DANRE", "mass": 75347.0, "length": 696, "protein_name": "Spermatid perinuclear RNA-binding protein", "gene_name": "strbp", "organism": "Zebrafish", "refseq_name": "spermatid perinuclear RNA-binding protein isoform X1", "refseq_ac": "XP_021334939", "gene_names_uniprotkb": "strbp", "gene_names_refseq": "strbp", "protein_names_uniprotkb": "Spermatid perinuclear RNA-binding protein", "protein_names_refseq": "spermatid perinuclear RNA-binding protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:557957)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B248-1", "uniprot_id": "A0A8M2B248_DANRE", "mass": 48406.0, "length": 428, "protein_name": "Interferon regulatory factor 9", "gene_name": "irf9", "organism": "Zebrafish", "refseq_name": "interferon regulatory factor 9", "refseq_ac": "NP_991273", "gene_names_uniprotkb": "irf9; ISGF3G; zgc:92097", "gene_names_refseq": "ISGF3G; irf9; zgc:92097", "protein_names_uniprotkb": "Interferon regulatory factor 9", "protein_names_refseq": "interferon regulatory factor 9", "tax_id": 7955, "disease": "immunodeficiency 65 (Disease Ontology:DOID:0111978); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatitis C (Disease Ontology:DOID:1883); acute pancreatitis (Disease Ontology:DOID:2913)", "pathway": " (dre:403013); (R-DRE-909733)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15520368;18039395;19896215;20438850;20444275;35464458;36577070;37106740;37293546;38275965", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01003573.1, GFIL01013497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH433167.1, EH504444.1, JBMGRA010000012.1, EH462679.1 and EH459171.1. On or before Jun 20, 2015 this sequence version replaced XP_005156115.1, NP_991273.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1Q573", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B274-1", "uniprot_id": "A0A8M2B274_DANRE", "mass": 38121.0, "length": 351, "protein_name": "Cdc42 effector protein 1", "gene_name": "cdc42ep1a", "organism": "Zebrafish", "refseq_name": "cdc42 effector protein 1", "refseq_ac": "XP_005156239", "gene_names_uniprotkb": "cdc42ep1a", "gene_names_refseq": "cdc42ep1a", "protein_names_uniprotkb": "Cdc42 effector protein 1", "protein_names_refseq": "cdc42 effector protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:101883603)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005156239.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B274-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B358-1", "uniprot_id": "A0A8M2B358_DANRE", "mass": 430633.0, "length": 3931, "protein_name": "Uncharacterized protein srcap isoform X1", "gene_name": "srcap", "organism": "Zebrafish", "refseq_name": "uncharacterized protein srcap isoform X1", "refseq_ac": "XP_073774611", "gene_names_uniprotkb": "srcap", "gene_names_refseq": "srcap", "protein_names_uniprotkb": "Uncharacterized protein srcap isoform X1", "protein_names_refseq": "uncharacterized protein srcap isoform X1", "tax_id": 7955, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); developmental disorder of mental health (Disease Ontology:DOID:0060037); Floating-Harbor syndrome (Disease Ontology:DOID:0111358)", "pathway": " (dre:563456)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GXZ7;A0AC58GY02;A0AC58GY09", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0000812 Swr1 complex", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B321-1", "uniprot_id": "A0A8M2B321_DANRE", "mass": 76132.0, "length": 695, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "rnf157", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin ligase RNF157 isoform X1", "refseq_ac": "XP_005156404", "gene_names_uniprotkb": "rnf157", "gene_names_refseq": "rnf157", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27; RING-type E3 ubiquitin transferase", "protein_names_refseq": "E3 ubiquitin ligase RNF157 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:555415)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; E3 ubiquitin ligase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2H1-1", "uniprot_id": "A0A8M2B2H1_DANRE", "mass": 69683.0, "length": 604, "protein_name": "Dynein axonemal intermediate chain 2", "gene_name": "dnai2b", "organism": "Zebrafish", "refseq_name": "dynein axonemal intermediate chain 2", "refseq_ac": "XP_005156459", "gene_names_uniprotkb": "dnai2b", "gene_names_refseq": "dnai2b", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 2", "protein_names_refseq": "dynein axonemal intermediate chain 2", "tax_id": 7955, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 9 (Disease Ontology:DOID:0110622); sensorineural hearing loss (Disease Ontology:DOID:10003); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dre:101884977)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0036157 outer dynein arm", "go_biological_process": "GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2Q0-1", "uniprot_id": "A0A8M2B2Q0_DANRE", "mass": 60492.0, "length": 519, "protein_name": "EGF domain-specific O-linked N-acetylglucosamine transferase", "gene_name": "eogt", "organism": "Zebrafish", "refseq_name": "EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1", "refseq_ac": "XP_005155877", "gene_names_uniprotkb": "eogt", "gene_names_refseq": "eogt", "protein_names_uniprotkb": "EGF domain-specific O-linked N-acetylglucosamine transferase; 2.4.1.255; Extracellular O-linked N-acetylglucosamine transferase", "protein_names_refseq": "EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1", "tax_id": 7955, "disease": "Adams-Oliver syndrome (Disease Ontology:DOID:0060227)", "pathway": " (dre:798087)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005155877.2. COMPLETENESS: full length., [RefSeq]; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.255", "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3E5-1", "uniprot_id": "A0A8M2B3E5_DANRE", "mass": 143276.0, "length": 1254, "protein_name": "Cell division cycle and apoptosis regulator protein 1", "gene_name": "ccar1", "organism": "Zebrafish", "refseq_name": "cell division cycle and apoptosis regulator protein 1 isoform X1", "refseq_ac": "XP_005156708", "gene_names_uniprotkb": "ccar1; hm:zehn1480; si:dkey-85g17.2; zehn1480", "gene_names_refseq": "ccar1; hm:zehn1480; si:dkey-85g17.2; zehn1480", "protein_names_uniprotkb": "Cell division cycle and apoptosis regulator protein 1", "protein_names_refseq": "cell division cycle and apoptosis regulator protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568087)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24396069;36574072;37867960", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005156708.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B3E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2S6-1", "uniprot_id": "A0A8M2B2S6_DANRE", "mass": 403762.0, "length": 3739, "protein_name": "Protein bassoon isoform X1", "gene_name": "bsnb", "organism": "Zebrafish", "refseq_name": "protein bassoon isoform X1", "refseq_ac": "XP_005155960", "gene_names_uniprotkb": "bsnb", "gene_names_refseq": "bsnb", "protein_names_uniprotkb": "Protein bassoon isoform X1", "protein_names_refseq": "protein bassoon isoform X1", "tax_id": 7955, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:101175706)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005155960.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0030424 axon;GO:0048788 cytoskeleton of presynaptic active zone", "go_biological_process": "GO:0035418 protein localization to synapse;GO:1904071 presynaptic active zone assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2S6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B2Z1-1", "uniprot_id": "A0A8M2B2Z1_DANRE", "mass": 33815.0, "length": 308, "protein_name": "LIM domain-binding protein 3b isoform X1", "gene_name": "ldb3b", "organism": "Zebrafish", "refseq_name": "LIM domain-binding protein 3b isoform X1", "refseq_ac": "XP_005156328", "gene_names_uniprotkb": "ldb3b; ldb3l; wu:fi31d08; zgc:55814", "gene_names_refseq": "ldb3b; ldb3l; wu:fi31d08; zgc:55814", "protein_names_uniprotkb": "LIM domain-binding protein 3b isoform X1", "protein_names_refseq": "LIM domain-binding protein 3b isoform X1", "tax_id": 7955, "disease": "myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); dilated cardiomyopathy 1C (Disease Ontology:DOID:0110423); distal myopathy (Disease Ontology:DOID:11720); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030018 Z disc", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B2Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B301-1", "uniprot_id": "A0A8M2B301_DANRE", "mass": 37966.0, "length": 331, "protein_name": "stearoyl-CoA 9-desaturase", "gene_name": "scdb", "organism": "Zebrafish", "refseq_name": "stearoyl-CoA desaturase b isoform X1", "refseq_ac": "XP_005156902", "gene_names_uniprotkb": "scdb; zgc:112951", "gene_names_refseq": "scdb; zgc:112951", "protein_names_uniprotkb": "stearoyl-CoA 9-desaturase; 1.14.19.1", "protein_names_refseq": "stearoyl-CoA desaturase b isoform X1", "tax_id": 7955, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); autosomal dominant nonsyndromic deafness 79 (Disease Ontology:DOID:0112160); hyperinsulinism (Disease Ontology:DOID:2018); carcinoma (Disease Ontology:DOID:305); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_005156902.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.19.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006636 unsaturated fatty acid biosynthetic process;GO:1903966 monounsaturated fatty acid biosynthetic process;GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B301-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B317-1", "uniprot_id": "A0A8M2B317_DANRE", "mass": 34300.0, "length": 300, "protein_name": "HLF transcription factor, PAR bZIP family member b isoform X1", "gene_name": "hlfb", "organism": "Zebrafish", "refseq_name": "HLF transcription factor, PAR bZIP family member b isoform X1", "refseq_ac": "XP_005156391", "gene_names_uniprotkb": "hlfb; hlf2", "gene_names_refseq": "hlf2; hlfb", "protein_names_uniprotkb": "HLF transcription factor, PAR bZIP family member b isoform X1", "protein_names_refseq": "HLF transcription factor, PAR bZIP family member b isoform X1", "tax_id": 7955, "disease": "stomach cancer (Disease Ontology:DOID:10534); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B339-1", "uniprot_id": "A0A8M2B339_DANRE", "mass": 38309.0, "length": 361, "protein_name": "Isoaspartyl peptidase/L-asparaginase", "gene_name": "si:dkey-103j14.5", "organism": "Zebrafish", "refseq_name": "isoaspartyl peptidase/L-asparaginase isoform X1", "refseq_ac": "XP_005156981", "gene_names_uniprotkb": "si:dkey-103j14.5", "gene_names_refseq": "si:dkey-103j14.5", "protein_names_uniprotkb": "Isoaspartyl peptidase/L-asparaginase; 3.4.19.5; 3.5.1.1; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase", "protein_names_refseq": "isoaspartyl peptidase/L-asparaginase isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570552)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005156981.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.5;3.5.1.1", "go_molecular_function": "GO:0004067 asparaginase activity;GO:0008798 beta-aspartyl-peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0033345 L-asparagine catabolic process via L-aspartate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B340-1", "uniprot_id": "A0A8M2B340_DANRE", "mass": 102891.0, "length": 923, "protein_name": "Sodium/calcium exchanger 3 isoform X1", "gene_name": "slc8a3", "organism": "Zebrafish", "refseq_name": "sodium/calcium exchanger 3 isoform X1", "refseq_ac": "XP_005157054", "gene_names_uniprotkb": "slc8a3", "gene_names_refseq": "slc8a3", "protein_names_uniprotkb": "Sodium/calcium exchanger 3 isoform X1", "protein_names_refseq": "sodium/calcium exchanger 3 isoform X1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity", "go_cellular_component": "GO:0030424 axon;GO:0098794 postsynapse;GO:0042383 sarcolemma;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0007154 cell communication;GO:0035725 sodium ion transmembrane transport;GO:1990034 calcium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B340-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3N1-1", "uniprot_id": "A0A8M2B3N1_DANRE", "mass": 115028.0, "length": 1066, "protein_name": "Zinc finger MIZ domain-containing protein 1a isoform X4", "gene_name": "zmiz1a", "organism": "Zebrafish", "refseq_name": "zinc finger MIZ domain-containing protein 1a isoform X4", "refseq_ac": "XP_005156912", "gene_names_uniprotkb": "zmiz1a; fb80e10; wu:fb80e10; zgc:175159; zmiz1", "gene_names_refseq": "fb80e10; wu:fb80e10; zgc:175159; zmiz1a; zmiz1", "protein_names_uniprotkb": "Zinc finger MIZ domain-containing protein 1a isoform X4", "protein_names_refseq": "zinc finger MIZ domain-containing protein 1a isoform X4", "tax_id": 7955, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1903706 regulation of hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3F2-1", "uniprot_id": "A0A8M2B3F2_DANRE", "mass": 71858.0, "length": 640, "protein_name": "Broad substrate specificity ATP-binding cassette transporter ABCG2c isoform X1", "gene_name": "abcg2c", "organism": "Zebrafish", "refseq_name": "broad substrate specificity ATP-binding cassette transporter ABCG2c isoform X1", "refseq_ac": "XP_005156580", "gene_names_uniprotkb": "abcg2c; im:6903440", "gene_names_refseq": "abcg2c; im:6903440", "protein_names_uniprotkb": "Broad substrate specificity ATP-binding cassette transporter ABCG2c isoform X1", "protein_names_refseq": "broad substrate specificity ATP-binding cassette transporter ABCG2c isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015562 efflux transmembrane transporter activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3F2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3F9-1", "uniprot_id": "A0A8M2B3F9_DANRE", "mass": 127552.0, "length": 1161, "protein_name": "Protocadherin-18b isoform X1", "gene_name": "pcdh18b", "organism": "Zebrafish", "refseq_name": "protocadherin-18b isoform X1", "refseq_ac": "XP_005157386", "gene_names_uniprotkb": "pcdh18b; fj19f12; pcdh18; wu:fj19f12", "gene_names_refseq": "fj19f12; pcdh18b; pcdh18; wu:fj19f12", "protein_names_uniprotkb": "Protocadherin-18b isoform X1", "protein_names_refseq": "protocadherin-18b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005157386.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0048812 neuron projection morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3G8-1", "uniprot_id": "A0A8M2B3G8_DANRE", "mass": 36772.0, "length": 326, "protein_name": "Calmodulin-lysine N-methyltransferase", "gene_name": "camkmt", "organism": "Zebrafish", "refseq_name": "calmodulin-lysine N-methyltransferase isoform X1", "refseq_ac": "XP_005156634", "gene_names_uniprotkb": "camkmt", "gene_names_refseq": "camkmt", "protein_names_uniprotkb": "Calmodulin-lysine N-methyltransferase; 2.1.1.60", "protein_names_refseq": "calmodulin-lysine N-methyltransferase isoform X1", "tax_id": 7955, "disease": "hypotonia-cystinuria syndrome (Disease Ontology:DOID:0060858)", "pathway": " (dre:796749)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the trimethylation of 'Lys-116' in calmodulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QKS9", "ec_number_list": "2.1.1.60", "go_molecular_function": "GO:0018025 calmodulin-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3H1-1", "uniprot_id": "A0A8M2B3H1_DANRE", "mass": 66925.0, "length": 598, "protein_name": "Suppressor of cytokine signaling 5b isoform X1", "gene_name": "socs5b", "organism": "Zebrafish", "refseq_name": "suppressor of cytokine signaling 5b isoform X1", "refseq_ac": "XP_005156658", "gene_names_uniprotkb": "socs5b; socs5l", "gene_names_refseq": "socs5b; socs5l", "protein_names_uniprotkb": "Suppressor of cytokine signaling 5b isoform X1", "protein_names_refseq": "suppressor of cytokine signaling 5b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005156658.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0016567 protein ubiquitination;GO:0009968 negative regulation of signal transduction;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3N8-1", "uniprot_id": "A0A8M2B3N8_DANRE", "mass": 38772.0, "length": 343, "protein_name": "Arfaptin-2a isoform X5", "gene_name": "arfip2a", "organism": "Zebrafish", "refseq_name": "arfaptin-2a isoform X5", "refseq_ac": "XP_005157419", "gene_names_uniprotkb": "arfip2a; fj35g06; wu:fj35g06; zgc:92579", "gene_names_refseq": "arfip2a; fj35g06; wu:fj35g06; zgc:92579", "protein_names_uniprotkb": "Arfaptin-2a isoform X5", "protein_names_refseq": "arfaptin-2a isoform X5", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0006886 intracellular protein transport;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B3Z6-1", "uniprot_id": "A0A8M2B3Z6_DANRE", "mass": 28057.0, "length": 246, "protein_name": "Vascular endothelial growth factor B isoform X1", "gene_name": "vegfba", "organism": "Zebrafish", "refseq_name": "vascular endothelial growth factor B isoform X1", "refseq_ac": "XP_005157219", "gene_names_uniprotkb": "vegfba", "gene_names_refseq": "vegfba", "protein_names_uniprotkb": "Vascular endothelial growth factor B isoform X1", "protein_names_refseq": "vascular endothelial growth factor B isoform X1", "tax_id": 7955, "disease": "myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:101885552)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005157219.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0061300 cerebellum vasculature development;GO:0001525 angiogenesis;GO:0051781 positive regulation of cell division;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B3Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B428-1", "uniprot_id": "A0A8M2B428_DANRE", "mass": 333536.0, "length": 3016, "protein_name": "Protocadherin Fat 4 isoform X1", "gene_name": "LOC101883589", "organism": "Zebrafish", "refseq_name": "protocadherin Fat 4 isoform X1", "refseq_ac": "XP_005157778", "gene_names_uniprotkb": "LOC101883589", "gene_names_refseq": "LOC101883589", "protein_names_uniprotkb": "Protocadherin Fat 4 isoform X1", "protein_names_refseq": "protocadherin Fat 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101883589)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005157778.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007409 axonogenesis;GO:0030855 epithelial cell differentiation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B428-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B444-1", "uniprot_id": "A0A8M2B444_DANRE", "mass": 14513.0, "length": 135, "protein_name": "Myelin basic protein", "gene_name": "mbpb", "organism": "Zebrafish", "refseq_name": "myelin basic protein b isoform X1", "refseq_ac": "XP_005157892", "gene_names_uniprotkb": "mbpb; sb:cb183; si:dkey-241k19.2; wu:fb71b08", "gene_names_refseq": "mbpb; sb:cb183; si:dkey-241k19.2; wu:fb71b08", "protein_names_uniprotkb": "Myelin basic protein", "protein_names_refseq": "myelin basic protein b isoform X1", "tax_id": 7955, "disease": "Huntington's disease (Disease Ontology:DOID:12858); periventricular leukomalacia (Disease Ontology:DOID:13088); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); demyelinating disease (Disease Ontology:DOID:3213); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dre:368319)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "24040667;24989451;26469318;27189481;28252024;32544203;33333712;36063998;37183607;37416774", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4B6-1", "uniprot_id": "A0A8M2B4B6_DANRE", "mass": 49556.0, "length": 451, "protein_name": "Reticulon", "gene_name": "rtn2a", "organism": "Zebrafish", "refseq_name": "reticulon-2a isoform X1", "refseq_ac": "XP_005157528", "gene_names_uniprotkb": "rtn2a; zgc:136255", "gene_names_refseq": "rtn2a; zgc:136255", "protein_names_uniprotkb": "Reticulon", "protein_names_refseq": "reticulon-2a isoform X1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0014069 postsynaptic density;GO:0043005 neuron projection", "go_biological_process": "GO:0007420 brain development;GO:0030182 neuron differentiation;GO:0071787 endoplasmic reticulum tubular network formation;GO:1990809 endoplasmic reticulum tubular network membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4C3-1", "uniprot_id": "A0A8M2B4C3_DANRE", "mass": 49368.0, "length": 458, "protein_name": "Transmembrane protease serine 4a isoform X1", "gene_name": "tmprss4a", "organism": "Zebrafish", "refseq_name": "transmembrane protease serine 4a isoform X1", "refseq_ac": "XP_005157547", "gene_names_uniprotkb": "tmprss4a; tmprss4; zgc:152909", "gene_names_refseq": "tmprss4a; tmprss4; zgc:152909", "protein_names_uniprotkb": "Transmembrane protease serine 4a isoform X1", "protein_names_refseq": "transmembrane protease serine 4a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005157547.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4F6-1", "uniprot_id": "A0A8M2B4F6_DANRE", "mass": 72720.0, "length": 645, "protein_name": "Cytoplasmic dynein 1 intermediate chain 1 isoform X1", "gene_name": "dync1i1b", "organism": "Zebrafish", "refseq_name": "cytoplasmic dynein 1 intermediate chain 1 isoform X1", "refseq_ac": "XP_005158174", "gene_names_uniprotkb": "dync1i1b; dync1i1; sb:eu1013; zgc:158394", "gene_names_refseq": "dync1i1b; dync1i1; sb:eu1013; zgc:158394", "protein_names_uniprotkb": "Cytoplasmic dynein 1 intermediate chain 1 isoform X1", "protein_names_refseq": "cytoplasmic dynein 1 intermediate chain 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4G6-1", "uniprot_id": "A0A8M2B4G6_DANRE", "mass": 18523.0, "length": 177, "protein_name": "Trafficking regulator of GLUT4 1", "gene_name": "trarg1a", "organism": "Zebrafish", "refseq_name": "trafficking regulator of GLUT4 1", "refseq_ac": "XP_021322105", "gene_names_uniprotkb": "trarg1a", "gene_names_refseq": "trarg1a", "protein_names_uniprotkb": "Trafficking regulator of GLUT4 1", "protein_names_refseq": "trafficking regulator of GLUT4 1", "tax_id": 7955, "disease": "", "pathway": " (dre:101886018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F6S5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0048675 axon extension;GO:0099638 endosome to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4K9-1", "uniprot_id": "A0A8M2B4K9_DANRE", "mass": 38675.0, "length": 342, "protein_name": "Odorant receptor 111-2 isoform X1", "gene_name": "or42e3", "organism": "Zebrafish", "refseq_name": "odorant receptor 111-2 isoform X1", "refseq_ac": "XP_005157754", "gene_names_uniprotkb": "or42e3; olfr2.4; or111-2; or15.41; or2.4", "gene_names_refseq": "olfr2.4; or111-2; or15.41; or2.4; or42e3", "protein_names_uniprotkb": "Odorant receptor 111-2 isoform X1", "protein_names_refseq": "odorant receptor 111-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4N7-1", "uniprot_id": "A0A8M2B4N7_DANRE", "mass": 91643.0, "length": 813, "protein_name": "MutS protein homolog 5", "gene_name": "msh5", "organism": "Zebrafish", "refseq_name": "mutS protein homolog 5 isoform X1", "refseq_ac": "XP_005157849", "gene_names_uniprotkb": "msh5", "gene_names_refseq": "msh5", "protein_names_uniprotkb": "MutS protein homolog 5", "protein_names_refseq": "mutS protein homolog 5 isoform X1", "tax_id": 7955, "disease": "spermatogenic failure 74 (Disease Ontology:DOID:0070573); primary ovarian insufficiency 13 (Disease Ontology:DOID:0080870); lung non-small cell carcinoma (Disease Ontology:DOID:3908); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dre:570030)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005157849.1. COMPLETENESS: full length., [RefSeq]; Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003690 double-stranded DNA binding;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006298 mismatch repair;GO:0051026 chiasma assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4U6-1", "uniprot_id": "A0A8M2B4U6_DANRE", "mass": 77881.0, "length": 688, "protein_name": "G patch domain-containing protein 3 isoform X1", "gene_name": "gpatch3", "organism": "Zebrafish", "refseq_name": "G patch domain-containing protein 3 isoform X1", "refseq_ac": "XP_005158511", "gene_names_uniprotkb": "gpatch3; zgc:158863", "gene_names_refseq": "gpatch3; zgc:158863", "protein_names_uniprotkb": "G patch domain-containing protein 3 isoform X1", "protein_names_refseq": "G patch domain-containing protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0045893 positive regulation of DNA-templated transcription;GO:0043010 camera-type eye development;GO:0039536 negative regulation of RIG-I signaling pathway;GO:0032480 negative regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4U7-1", "uniprot_id": "A0A8M2B4U7_DANRE", "mass": 37554.0, "length": 337, "protein_name": "Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (Glutamate binding)", "gene_name": "grinab", "organism": "Zebrafish", "refseq_name": "glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding)", "refseq_ac": "NP_001295540", "gene_names_uniprotkb": "grinab; grina; tmbim3; zgc:64102", "gene_names_refseq": "grinab; grina; tmbim3; zgc:64102", "protein_names_uniprotkb": "Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (Glutamate binding)", "protein_names_refseq": "glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding)", "tax_id": 7955, "disease": "", "pathway": " (dre:394183)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22240901;27903883;31171717", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01004918.1, GDQQ01003411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH541500.1, EH562651.1 and JBMGRA010000016.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QKT8", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B4U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4V9-1", "uniprot_id": "A0A8M2B4V9_DANRE", "mass": 80370.0, "length": 708, "protein_name": "Ras guanyl-releasing protein 3 isoform X1", "gene_name": "rasgrp3", "organism": "Zebrafish", "refseq_name": "ras guanyl-releasing protein 3 isoform X1", "refseq_ac": "XP_073783456", "gene_names_uniprotkb": "rasgrp3; zgc:162151", "gene_names_refseq": "rasgrp3; zgc:162151", "protein_names_uniprotkb": "Ras guanyl-releasing protein 3 isoform X1", "protein_names_refseq": "ras guanyl-releasing protein 3 isoform X1", "tax_id": 7955, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (R-DRE-1169092); (R-DRE-5673001)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HN89;A0AC58HNA8;A0AC58HNB8;F1QFI3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B4V9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B4X4-1", "uniprot_id": "A0A8M2B4X4_DANRE", "mass": 49134.0, "length": 439, "protein_name": "pantothenate kinase", "gene_name": "pank1a", "organism": "Zebrafish", "refseq_name": "pantothenate kinase 1a isoform X1", "refseq_ac": "XP_005158562", "gene_names_uniprotkb": "pank1a; fb79e08; wu:fb79e08; zgc:63556", "gene_names_refseq": "fb79e08; pank1a; wu:fb79e08; zgc:63556", "protein_names_uniprotkb": "pantothenate kinase; 2.7.1.33", "protein_names_refseq": "pantothenate kinase 1a isoform X1", "tax_id": 7955, "disease": "pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981)", "pathway": " (dre:406789)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21195142;23947337;26476142;27189481;30252882;32334837;36361705", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.33", "go_molecular_function": "GO:0005524 ATP binding;GO:0004594 pantothenate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0001878 response to yeast;GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2B4X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B505-1", "uniprot_id": "A0A8M2B505_DANRE", "mass": 69936.0, "length": 632, "protein_name": "Semaphorin-1A", "gene_name": "si:ch211-113g11.6", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005158115", "gene_names_uniprotkb": "si:ch211-113g11.6; fa11e10; wu:fa11e10", "gene_names_refseq": "fa11e10; si:ch211-113g11.6; wu:fa11e10", "protein_names_uniprotkb": "Semaphorin-1A", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559008)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;27615194;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HGW0", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B539-1", "uniprot_id": "A0A8M2B539_DANRE", "mass": 149281.0, "length": 1332, "protein_name": "AT-rich interactive domain-containing protein 4A", "gene_name": "arid4a", "organism": "Zebrafish", "refseq_name": "AT-rich interactive domain-containing protein 4A isoform X1", "refseq_ac": "XP_005158686", "gene_names_uniprotkb": "arid4a; fc43f03; fi11g07; fi14h03; wu:fc43f03; wu:fi06c05; wu:fi11g07; wu:fi14h03; zgc:110391", "gene_names_refseq": "arid4a; fc43f03; fi11g07; fi14h03; wu:fc43f03; wu:fi06c05; wu:fi11g07; wu:fi14h03; zgc:110391", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 4A; Retinoblastoma-binding protein 1", "protein_names_refseq": "AT-rich interactive domain-containing protein 4A isoform X1", "tax_id": 7955, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (R-DRE-3214815)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor). May function as part of an mSin3A repressor complex. Has no intrinsic transcriptional activity. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B. Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HM79;A0AC58HM83;K7DY37", "ec_number_list": "", "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B571-1", "uniprot_id": "A0A8M2B571_DANRE", "mass": 78874.0, "length": 717, "protein_name": "Striatin-3 isoform X1", "gene_name": "strn3", "organism": "Zebrafish", "refseq_name": "striatin-3 isoform X1", "refseq_ac": "XP_005158841", "gene_names_uniprotkb": "strn3; GS2NA; id:ibd1241; si:busm1-115o7.2; si:dz115o7.2; si:dz234g15.7; wu:fc02f06", "gene_names_refseq": "GS2NA; id:ibd1241; si:busm1-115o7.2; si:dz115o7.2; si:dz234g15.7; strn3; wu:fc02f06", "protein_names_uniprotkb": "Striatin-3 isoform X1", "protein_names_refseq": "striatin-3 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005158841.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0098794 postsynapse;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B571-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5B2-1", "uniprot_id": "A0A8M2B5B2_DANRE", "mass": 31402.0, "length": 273, "protein_name": "Microtubule-associated protein RP/EB family member 3", "gene_name": "mapre3a", "organism": "Zebrafish", "refseq_name": "microtubule-associated protein RP/EB family member 3a isoform X1", "refseq_ac": "XP_005158903", "gene_names_uniprotkb": "mapre3a; zgc:114065", "gene_names_refseq": "mapre3a; zgc:114065", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 3; EB1 protein family member 3; End-binding protein 3; RP3", "protein_names_refseq": "microtubule-associated protein RP/EB family member 3a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0051233 spindle midzone;GO:0005815 microtubule organizing center;GO:0005881 cytoplasmic microtubule;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0051225 spindle assembly;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5E9-1", "uniprot_id": "A0A8M2B5E9_DANRE", "mass": 62764.0, "length": 565, "protein_name": "Complement component C1q receptor isoform X1", "gene_name": "cd93", "organism": "Zebrafish", "refseq_name": "complement component C1q receptor isoform X1", "refseq_ac": "XP_005159016", "gene_names_uniprotkb": "cd93", "gene_names_refseq": "cd93", "protein_names_uniprotkb": "Complement component C1q receptor isoform X1", "protein_names_refseq": "complement component C1q receptor isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882826)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0002040 sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5X7-1", "uniprot_id": "A0A8M2B5X7_DANRE", "mass": 220284.0, "length": 2049, "protein_name": "Kinesin-like protein KIF26A isoform X1", "gene_name": "kif26ab", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF26A isoform X1", "refseq_ac": "XP_005159017", "gene_names_uniprotkb": "kif26ab", "gene_names_refseq": "kif26ab", "protein_names_uniprotkb": "Kinesin-like protein KIF26A isoform X1", "protein_names_refseq": "kinesin-like protein KIF26A isoform X1", "tax_id": 7955, "disease": "complex cortical dysplasia with other brain malformations 11 (Disease Ontology:DOID:0061142)", "pathway": " (dre:58004)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0048731 system development;GO:0007018 microtubule-based movement;GO:0007281 germ cell development;GO:0010975 regulation of neuron projection development;GO:2001222 regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5Y1-1", "uniprot_id": "A0A8M2B5Y1_DANRE", "mass": 43199.0, "length": 366, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "cers3b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005159054", "gene_names_uniprotkb": "cers3b; cers3; zgc:171494", "gene_names_refseq": "cers3b; cers3; zgc:171494", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "autosomal recessive congenital ichthyosis 9 (Disease Ontology:DOID:0060718)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5P7-1", "uniprot_id": "A0A8M2B5P7_DANRE", "mass": 29891.0, "length": 263, "protein_name": "Major histocompatibility complex class II DBB isoform X1", "gene_name": "mhc2dbb", "organism": "Zebrafish", "refseq_name": "major histocompatibility complex class II DBB isoform X1", "refseq_ac": "XP_005159251", "gene_names_uniprotkb": "mhc2dbb; DBB; mhc2d18b; si:busm1-241h12.1; si:dz241h12.1; zgc:153067", "gene_names_refseq": "DBB; mhc2d18b; mhc2dbb; si:busm1-241h12.1; si:dz241h12.1; zgc:153067", "protein_names_uniprotkb": "Major histocompatibility complex class II DBB isoform X1", "protein_names_refseq": "major histocompatibility complex class II DBB isoform X1", "tax_id": 7955, "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chikungunya (Disease Ontology:DOID:0050012); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); erythema multiforme (Disease Ontology:DOID:0050185); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); marginal zone lymphoma (Disease Ontology:DOID:0050748); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); cervical dystonia (Disease Ontology:DOID:0050840); stroke (Disease Ontology:DOID:0051061); immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); latex allergy (Disease Ontology:DOID:0060532); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); pemphigus vulgaris (Disease Ontology:DOID:0060851); lupus nephritis (Disease Ontology:DOID:0080162); occupational asthma (Disease Ontology:DOID:0080820); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); graft-versus-host disease (Disease Ontology:DOID:0081267); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); sensorineural hearing loss (Disease Ontology:DOID:10003); osteomyelitis (Disease Ontology:DOID:1019); leprosy (Disease Ontology:DOID:1024); prostate cancer (Disease Ontology:DOID:10283); pneumoconiosis (Disease Ontology:DOID:10316); silicosis (Disease Ontology:DOID:10325); bacterial infectious disease (Disease Ontology:DOID:104); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); sickle cell anemia (Disease Ontology:DOID:10923); Alport syndrome (Disease Ontology:DOID:10983); common wart (Disease Ontology:DOID:11165); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); sarcoidosis (Disease Ontology:DOID:11335); rhinoscleroma (Disease Ontology:DOID:11336); pneumocystosis (Disease Ontology:DOID:11339); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); degenerative myopia (Disease Ontology:DOID:11829); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); sympathetic ophthalmia (Disease Ontology:DOID:12029); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); Chagas disease (Disease Ontology:DOID:12140); alveolar echinococcosis (Disease Ontology:DOID:12148); common variable immunodeficiency (Disease Ontology:DOID:12177); beta thalassemia (Disease Ontology:DOID:12241); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); vulva cancer (Disease Ontology:DOID:1245); paracoccidioidomycosis (Disease Ontology:DOID:12662); autistic disorder (Disease Ontology:DOID:12849); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); thromboangiitis obliterans (Disease Ontology:DOID:12918); dilated cardiomyopathy (Disease Ontology:DOID:12930); agranulocytosis (Disease Ontology:DOID:12987); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); temporal arteritis (Disease Ontology:DOID:13375); pure red-cell aplasia (Disease Ontology:DOID:1340); uveoparotid fever (Disease Ontology:DOID:13404); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Addison's disease (Disease Ontology:DOID:13774); polyneuropathy (Disease Ontology:DOID:1389); schistosomiasis (Disease Ontology:DOID:1395); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); urticaria (Disease Ontology:DOID:1555); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); dental caries (Disease Ontology:DOID:216); multiple sclerosis (Disease Ontology:DOID:2377); Takayasu's arteritis (Disease Ontology:DOID:2508); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); antiphospholipid syndrome (Disease Ontology:DOID:2988); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); myelitis (Disease Ontology:DOID:322); breast carcinoma (Disease Ontology:DOID:3459); mixed connective tissue disease (Disease Ontology:DOID:3492); cerebral infarction (Disease Ontology:DOID:3526); tuberculosis (Disease Ontology:DOID:399); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); liver disease (Disease Ontology:DOID:409); autoimmune disease (Disease Ontology:DOID:417); cervical cancer (Disease Ontology:DOID:4362); myasthenia gravis (Disease Ontology:DOID:437); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); peptic ulcer disease (Disease Ontology:DOID:750); stomach disease (Disease Ontology:DOID:76); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); myocarditis (Disease Ontology:DOID:820); arthritis (Disease Ontology:DOID:848); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); mycosis fungoides (Disease Ontology:DOID:8691); Crohn's disease (Disease Ontology:DOID:8778); neuromyelitis optica (Disease Ontology:DOID:8869); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); atrophic gastritis (Disease Ontology:DOID:8929); diabetic retinopathy (Disease Ontology:DOID:8947); narcolepsy (Disease Ontology:DOID:8986); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); achalasia (Disease Ontology:DOID:9164); pemphigus (Disease Ontology:DOID:9182); colorectal cancer (Disease Ontology:DOID:9256); iridocyclitis (Disease Ontology:DOID:9383); allergic asthma (Disease Ontology:DOID:9415); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Meniere's disease (Disease Ontology:DOID:9849); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 152, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0006955 immune response;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5Q5-1", "uniprot_id": "A0A8M2B5Q5_DANRE", "mass": 212096.0, "length": 1837, "protein_name": "Intersectin-2b isoform X1", "gene_name": "itsn2b", "organism": "Zebrafish", "refseq_name": "intersectin-2b isoform X1", "refseq_ac": "XP_005158835", "gene_names_uniprotkb": "itsn2b; im:7149072; si:ch211-175f11.2", "gene_names_refseq": "im:7149072; itsn2b; si:ch211-175f11.2", "protein_names_uniprotkb": "Intersectin-2b isoform X1", "protein_names_refseq": "intersectin-2b isoform X1", "tax_id": 7955, "disease": "intellectual disability (Disease Ontology:DOID:1059); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (dre:445153)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27189481;32722765", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005158835.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006897 endocytosis;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2B5Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5S0-1", "uniprot_id": "A0A8M2B5S0_DANRE", "mass": 60285.0, "length": 551, "protein_name": "ADP-ribosylation factor GTPase-activating protein 2", "gene_name": "arfgap2", "organism": "Zebrafish", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 2 isoform X1", "refseq_ac": "XP_005159305", "gene_names_uniprotkb": "arfgap2; im:7148924; zgc:123303", "gene_names_refseq": "arfgap2; im:7148924; zgc:123303", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 2; Zinc finger protein 289", "protein_names_refseq": "ADP-ribosylation factor GTPase-activating protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5T2-1", "uniprot_id": "A0A8M2B5T2_DANRE", "mass": 134187.0, "length": 1219, "protein_name": "Zinc finger protein 592 isoform X1", "gene_name": "znf592", "organism": "Zebrafish", "refseq_name": "zinc finger protein 592 isoform X1", "refseq_ac": "XP_005159353", "gene_names_uniprotkb": "znf592; wu:fj94a04", "gene_names_refseq": "wu:fj94a04; znf592", "protein_names_uniprotkb": "Zinc finger protein 592 isoform X1", "protein_names_refseq": "zinc finger protein 592 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:571276)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26377317;26469318;28789986;32959503", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B5T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B5U6-1", "uniprot_id": "A0A8M2B5U6_DANRE", "mass": 53117.0, "length": 492, "protein_name": "AP-5 complex subunit mu-1", "gene_name": "ap5m1", "organism": "Zebrafish", "refseq_name": "AP-5 complex subunit mu-1", "refseq_ac": "NP_001018490", "gene_names_uniprotkb": "ap5m1; zgc:112153", "gene_names_refseq": "ap5m1; ovy; zgc:112153", "protein_names_uniprotkb": "AP-5 complex subunit mu-1; Adaptor-related protein complex 5 subunit mu-1", "protein_names_refseq": "AP-5 complex subunit mu-1; adaptor-related protein complex 5, mu 1 subunit", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588734.2701337.1, GFIL01001205.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505372 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On or before Jul 31, 2025 this sequence version replaced XP_005158951.1, NP_001018490.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HN26;A0AC58HN38", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B5U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B675-1", "uniprot_id": "A0A8M2B675_DANRE", "mass": 15468.0, "length": 136, "protein_name": "Neuromedin Ba isoform X1", "gene_name": "nmba", "organism": "Zebrafish", "refseq_name": "neuromedin Ba isoform X1", "refseq_ac": "XP_005159359", "gene_names_uniprotkb": "nmba; si:dkey-77f17.8", "gene_names_refseq": "nmba; si:dkey-77f17.8", "protein_names_uniprotkb": "Neuromedin Ba isoform X1", "protein_names_refseq": "neuromedin Ba isoform X1", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:798102)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "27705817;28789986;32867764;38819436", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031710 neuromedin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0046887 positive regulation of hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6B1-1", "uniprot_id": "A0A8M2B6B1_DANRE", "mass": 45512.0, "length": 394, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "ck2a1", "organism": "Zebrafish", "refseq_name": "STKc_CK2_alpha domain-containing protein isoform X1", "refseq_ac": "XP_005159385", "gene_names_uniprotkb": "ck2a1; im:6891713; si:ch211-133n4.5; zgc:86598", "gene_names_refseq": "ck2a1; im:6891713; si:ch211-133n4.5; zgc:86598", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "STKc_CK2_alpha domain-containing protein isoform X1", "tax_id": 7955, "disease": "breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005956 protein kinase CK2 complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6D5-1", "uniprot_id": "A0A8M2B6D5_DANRE", "mass": 96520.0, "length": 871, "protein_name": "Programmed cell death 6-interacting protein", "gene_name": "pdcd6ip", "organism": "Zebrafish", "refseq_name": "programmed cell death 6-interacting protein isoform X1", "refseq_ac": "XP_005159794", "gene_names_uniprotkb": "pdcd6ip; wu:fb70d03; wu:fy65h02; zgc:63638", "gene_names_refseq": "pdcd6ip; wu:fb70d03; wu:fy65h02; zgc:63638", "protein_names_uniprotkb": "Programmed cell death 6-interacting protein", "protein_names_refseq": "programmed cell death 6-interacting protein isoform X1", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 29 (Disease Ontology:DOID:0051040)", "pathway": " (dre:406669)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16109975;26469318;27189481;28092764;28252024;30564460;32173581;34882480;35628321", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0090543 Flemming body;GO:0005737 cytoplasm", "go_biological_process": "GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2B6D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6I1-1", "uniprot_id": "A0A8M2B6I1_DANRE", "mass": 69373.0, "length": 632, "protein_name": "Protein shisa-7 isoform X1", "gene_name": "shisa7b", "organism": "Zebrafish", "refseq_name": "protein shisa-7 isoform X1", "refseq_ac": "XP_003200596", "gene_names_uniprotkb": "shisa7b", "gene_names_refseq": "shisa7b", "protein_names_uniprotkb": "Protein shisa-7 isoform X1", "protein_names_refseq": "protein shisa-7 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I063;A0AC58I069;A0AC58I087;F1QF88;F1QXV0", "ec_number_list": "", "go_molecular_function": "GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0016020 membrane;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0032591 dendritic spine membrane", "go_biological_process": "GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007214 gamma-aminobutyric acid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6G6-1", "uniprot_id": "A0A8M2B6G6_DANRE", "mass": 43810.0, "length": 373, "protein_name": "Carbohydrate sulfotransferase", "gene_name": "chst12b.1", "organism": "Zebrafish", "refseq_name": "carbohydrate sulfotransferase 12b, tandem duplicate 1", "refseq_ac": "NP_001429470", "gene_names_uniprotkb": "chst12b.1", "gene_names_refseq": "chst12b.1; chst12b; si:dkey-26i13.10", "protein_names_uniprotkb": "Carbohydrate sulfotransferase; 2.8.2.-", "protein_names_refseq": "carbohydrate (chondroitin 4) sulfotransferase 12b; carbohydrate sulfotransferase 12b, tandem duplicate 1", "tax_id": 7955, "disease": "", "pathway": " (dre:797290)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588730.9330235.1, SRR32588718.16047544.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505392 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Aug 12, 2025 this sequence version replaced XP_005159878.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6W6-1", "uniprot_id": "A0A8M2B6W6_DANRE", "mass": 116982.0, "length": 1099, "protein_name": "Mastermind-like protein 3", "gene_name": "maml3", "organism": "Zebrafish", "refseq_name": "mastermind-like protein 3", "refseq_ac": "XP_005160069", "gene_names_uniprotkb": "maml3", "gene_names_refseq": "maml3", "protein_names_uniprotkb": "Mastermind-like protein 3", "protein_names_refseq": "mastermind-like protein 3", "tax_id": 7955, "disease": "", "pathway": " (dre:101886283)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0007221 positive regulation of transcription of Notch receptor target", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6Y3-1", "uniprot_id": "A0A8M2B6Y3_DANRE", "mass": 60488.0, "length": 564, "protein_name": "Sodium/hydrogen exchanger 9B2", "gene_name": "si:dkey-162b23.4", "organism": "Zebrafish", "refseq_name": "sodium/hydrogen exchanger 9B2", "refseq_ac": "XP_005160140", "gene_names_uniprotkb": "si:dkey-162b23.4", "gene_names_refseq": "si:dkey-162b23.4", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 9B2", "protein_names_refseq": "sodium/hydrogen exchanger 9B2", "tax_id": 7955, "disease": "", "pathway": " (dre:571064); (R-DRE-2672351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E7FBR3", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B6Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B6Z2-1", "uniprot_id": "A0A8M2B6Z2_DANRE", "mass": 139901.0, "length": 1414, "protein_name": "Collagen alpha-1(XVII) chain", "gene_name": "col17a1a", "organism": "Zebrafish", "refseq_name": "collagen, type XVII, alpha 1a isoform X1", "refseq_ac": "XP_005160168", "gene_names_uniprotkb": "col17a1a; si:ch211-281g13.3", "gene_names_refseq": "col17a1a; si:ch211-281g13.3", "protein_names_uniprotkb": "Collagen alpha-1(XVII) chain; 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2", "protein_names_refseq": "collagen, type XVII, alpha 1a isoform X1", "tax_id": 7955, "disease": "junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); epithelial recurrent erosion dystrophy (Disease Ontology:DOID:0070337); junctional epidermolysis bullosa (Disease Ontology:DOID:3209)", "pathway": " (dre:557257)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20670682;21191402;26469318;26786512;27189481;30312775;35782869;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0030056 hemidesmosome", "go_biological_process": "GO:0008544 epidermis development;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B6Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B700-1", "uniprot_id": "A0A8M2B700_DANRE", "mass": 49723.0, "length": 432, "protein_name": "Hexosyltransferase", "gene_name": "b3gnt2a", "organism": "Zebrafish", "refseq_name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2a isoform X1", "refseq_ac": "XP_005160201", "gene_names_uniprotkb": "b3gnt2a; si:ch211-213b8.3; ssp2", "gene_names_refseq": "b3gnt2a; si:ch211-213b8.3; ssp2", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B704-1", "uniprot_id": "A0A8M2B704_DANRE", "mass": 83146.0, "length": 717, "protein_name": "Testis-specific gene 10 protein isoform X1", "gene_name": "tsga10", "organism": "Zebrafish", "refseq_name": "testis-specific gene 10 protein isoform X1", "refseq_ac": "XP_005160173", "gene_names_uniprotkb": "tsga10; zgc:152952", "gene_names_refseq": "tsga10; zgc:152952", "protein_names_uniprotkb": "Testis-specific gene 10 protein isoform X1", "protein_names_refseq": "testis-specific gene 10 protein isoform X1", "tax_id": 7955, "disease": "spermatogenic failure 26 (Disease Ontology:DOID:0111924)", "pathway": " (dre:768146)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;29520105;32149372;35445010", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0005814 centriole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B704-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B706-1", "uniprot_id": "A0A8M2B706_DANRE", "mass": 44670.0, "length": 398, "protein_name": "D(1B) dopamine receptor", "gene_name": "drd5b", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "drd5b; LOC567498", "gene_names_refseq": "", "protein_names_uniprotkb": "D(1B) dopamine receptor; D(5) dopamine receptor; Dopamine D5 receptor", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:567498)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004938 alpha2-adrenergic receptor activity;GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B706-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B779-1", "uniprot_id": "A0A8M2B779_DANRE", "mass": 146046.0, "length": 1297, "protein_name": "ribonuclease H", "gene_name": "LOC110437848", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_005160433", "gene_names_uniprotkb": "LOC110437848", "gene_names_refseq": "LOC110437848", "protein_names_uniprotkb": "ribonuclease H; 3.1.26.4", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:110437848)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005160433.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "", "go_biological_process": "GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7A4-1", "uniprot_id": "A0A8M2B7A4_DANRE", "mass": 83400.0, "length": 716, "protein_name": "Tumor necrosis factor alpha-induced protein 2a isoform X1", "gene_name": "tnfaip2a", "organism": "Zebrafish", "refseq_name": "tumor necrosis factor alpha-induced protein 2a isoform X1", "refseq_ac": "XP_005160524", "gene_names_uniprotkb": "tnfaip2a; si:dkeyp-72h1.2; zgc:136606", "gene_names_refseq": "si:dkeyp-72h1.2; tnfaip2a; zgc:136606", "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 2a isoform X1", "protein_names_refseq": "tumor necrosis factor alpha-induced protein 2a isoform X1", "tax_id": 7955, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (dre:567159)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;28252024;28385952", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005160524.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0000145 exocyst", "go_biological_process": "GO:0051601 exocyst localization;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B7A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7L4-1", "uniprot_id": "A0A8M2B7L4_DANRE", "mass": 84676.0, "length": 769, "protein_name": "E3 ubiquitin-protein ligase LNX isoform X1", "gene_name": "lnx1", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase LNX isoform X1", "refseq_ac": "XP_005160562", "gene_names_uniprotkb": "lnx1; fj78f06; lnx; si:dkey-12h2.1; wu:fj78f06; zgc:152906", "gene_names_refseq": "fj78f06; lnx1; lnx; si:dkey-12h2.1; wu:fj78f06; zgc:152906", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase LNX isoform X1", "protein_names_refseq": "E3 ubiquitin-protein ligase LNX isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:561226)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;19668196;26392552;27581768;28440030;30833887;35740282", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2B7L4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7E4-1", "uniprot_id": "A0A8M2B7E4_DANRE", "mass": 34550.0, "length": 312, "protein_name": "Cell division cycle-associated protein 4 isoform X1", "gene_name": "cdca4", "organism": "Zebrafish", "refseq_name": "cell division cycle-associated protein 4 isoform X1", "refseq_ac": "XP_068071526", "gene_names_uniprotkb": "cdca4; fb78b08; si:dkey-177p2.7; wu:fb78b08; zgc:92217", "gene_names_refseq": "cdca4; fb78b08; si:dkey-177p2.7; wu:fb78b08; zgc:92217", "protein_names_uniprotkb": "Cell division cycle-associated protein 4 isoform X1", "protein_names_refseq": "cell division cycle-associated protein 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:494037)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17703193;19159490;26469318;27189481;29700229", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I2R1", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B7E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7G6-1", "uniprot_id": "A0A8M2B7G6_DANRE", "mass": 59763.0, "length": 544, "protein_name": "Low-density lipoprotein receptor-related protein 11", "gene_name": "lrp11", "organism": "Zebrafish", "refseq_name": "low-density lipoprotein receptor-related protein 11 isoform X1", "refseq_ac": "XP_005160377", "gene_names_uniprotkb": "lrp11; si:dkey-181i3.7; wu:fj36e03", "gene_names_refseq": "lrp11; si:dkey-181i3.7; wu:fj36e03", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 11", "protein_names_refseq": "low-density lipoprotein receptor-related protein 11 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569216)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25217480;26469318;27189481;38660750", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B7G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7G9-1", "uniprot_id": "A0A8M2B7G9_DANRE", "mass": 73861.0, "length": 638, "protein_name": "Macoilin isoform X1", "gene_name": "si:dkey-12h9.6", "organism": "Zebrafish", "refseq_name": "macoilin isoform X1", "refseq_ac": "XP_021329039", "gene_names_uniprotkb": "si:dkey-12h9.6", "gene_names_refseq": "si:dkey-12h9.6", "protein_names_uniprotkb": "Macoilin isoform X1", "protein_names_refseq": "macoilin isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569780)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0030867 rough endoplasmic reticulum membrane", "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B7G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7J5-1", "uniprot_id": "A0A8M2B7J5_DANRE", "mass": 56144.0, "length": 478, "protein_name": "Serine/threonine protein phosphatase 2A regulatory subunit", "gene_name": "ppp2r5a", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform", "refseq_ac": "XP_005160499", "gene_names_uniprotkb": "ppp2r5a", "gene_names_refseq": "ppp2r5a", "protein_names_uniprotkb": "Serine/threonine protein phosphatase 2A regulatory subunit", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:562460)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B7J5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7M4-1", "uniprot_id": "A0A8M2B7M4_DANRE", "mass": 256289.0, "length": 2323, "protein_name": "Transcription factor HIVEP2a isoform X1", "gene_name": "hivep2a", "organism": "Zebrafish", "refseq_name": "transcription factor HIVEP2a isoform X1", "refseq_ac": "XP_068071600", "gene_names_uniprotkb": "hivep2a; hivep2; si:ch211-157m21.1", "gene_names_refseq": "hivep2a; hivep2; si:ch211-157m21.1", "protein_names_uniprotkb": "Transcription factor HIVEP2a isoform X1", "protein_names_refseq": "transcription factor HIVEP2a isoform X1", "tax_id": 7955, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); autosomal dominant intellectual developmental disorder 43 (Disease Ontology:DOID:0070073); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); asthma (Disease Ontology:DOID:2841); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:562048)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27376691;28855284", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A286Y903;A0AC58I3W1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B7M4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7P4-1", "uniprot_id": "A0A8M2B7P4_DANRE", "mass": 252706.0, "length": 2239, "protein_name": "Myomegalin isoform X1", "gene_name": "pde4dip", "organism": "Zebrafish", "refseq_name": "myomegalin isoform X1", "refseq_ac": "XP_005160852", "gene_names_uniprotkb": "pde4dip", "gene_names_refseq": "pde4dip", "protein_names_uniprotkb": "Myomegalin isoform X1", "protein_names_refseq": "myomegalin isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:566905)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0007098 centrosome cycle;GO:1903358 regulation of Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B7P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7S1-1", "uniprot_id": "A0A8M2B7S1_DANRE", "mass": 86507.0, "length": 791, "protein_name": "RalBP1-associated Eps domain-containing protein 1 isoform X1", "gene_name": "reps1", "organism": "Zebrafish", "refseq_name": "ralBP1-associated Eps domain-containing protein 1 isoform X1", "refseq_ac": "XP_005160888", "gene_names_uniprotkb": "reps1; si:dkey-217m5.1; wu:fj85c06", "gene_names_refseq": "reps1; si:dkey-217m5.1; wu:fj85c06", "protein_names_uniprotkb": "RalBP1-associated Eps domain-containing protein 1 isoform X1", "protein_names_refseq": "ralBP1-associated Eps domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734)", "pathway": " (dre:564535)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520368;26469318;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B7S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B822-1", "uniprot_id": "A0A8M2B822_DANRE", "mass": 74201.0, "length": 656, "protein_name": "Zinc finger protein 512", "gene_name": "znf512", "organism": "Zebrafish", "refseq_name": "zinc finger protein 512 isoform X1", "refseq_ac": "XP_005160899", "gene_names_uniprotkb": "znf512", "gene_names_refseq": "znf512", "protein_names_uniprotkb": "Zinc finger protein 512", "protein_names_refseq": "zinc finger protein 512 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882368)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B822-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7T7-1", "uniprot_id": "A0A8M2B7T7_DANRE", "mass": 81922.0, "length": 677, "protein_name": "Secretogranin-1 isoform X1", "gene_name": "chgb", "organism": "Zebrafish", "refseq_name": "secretogranin-1 isoform X1", "refseq_ac": "XP_005160930", "gene_names_uniprotkb": "chgb; si:ch73-355e4.2; si:cu075930.2", "gene_names_refseq": "chgb; si:ch73-355e4.2; si:cu075930.2", "protein_names_uniprotkb": "Secretogranin-1 isoform X1", "protein_names_refseq": "secretogranin-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:792853)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;28837622;35588359", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005160930.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B7T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7W1-1", "uniprot_id": "A0A8M2B7W1_DANRE", "mass": 63908.0, "length": 578, "protein_name": "Eukaryotic translation elongation factor 1 delta b (Guanine nucleotide exchange protein) isoform X1", "gene_name": "eef1db", "organism": "Zebrafish", "refseq_name": "eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform X1", "refseq_ac": "XP_005160975", "gene_names_uniprotkb": "eef1db; eef1d; im:7233939; si:dkey-235d18.4; wu:fa14f09; zgc:114052", "gene_names_refseq": "eef1db; eef1d; im:7233939; si:dkey-235d18.4; wu:fa14f09; zgc:114052", "protein_names_uniprotkb": "Eukaryotic translation elongation factor 1 delta b (Guanine nucleotide exchange protein) isoform X1", "protein_names_refseq": "eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein) isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:560745)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;16109975;20160088;26469318;27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003746 translation elongation factor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005853 eukaryotic translation elongation factor 1 complex;GO:0005829 cytosol", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2B7W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B7W3-1", "uniprot_id": "A0A8M2B7W3_DANRE", "mass": 27536.0, "length": 242, "protein_name": "Uncharacterized protein LOC100150691; Uncharacterized protein isoform X1", "gene_name": "si:ch73-299h12.6", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC100150691", "refseq_ac": "NP_001138292", "gene_names_uniprotkb": "si:ch73-299h12.6; si:rp71-1h20.2; si:rp71-1h20.3; si:rp71-1h20.4", "gene_names_refseq": "si:ch73-299h12.6; si:rp71-1h20.2; si:rp71-1h20.3; si:rp71-1h20.4", "protein_names_uniprotkb": "Uncharacterized protein LOC100150691; Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein LOC100150691", "tax_id": 7955, "disease": "", "pathway": " (dre:100150691); (R-DRE-3899300)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IDJ9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2B7W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B806-1", "uniprot_id": "A0A8M2B806_DANRE", "mass": 141328.0, "length": 1294, "protein_name": "Zinc finger protein 532", "gene_name": "znf532", "organism": "Zebrafish", "refseq_name": "zinc finger protein 532 isoform X1", "refseq_ac": "XP_068072099", "gene_names_uniprotkb": "znf532", "gene_names_refseq": "znf532", "protein_names_uniprotkb": "Zinc finger protein 532", "protein_names_refseq": "zinc finger protein 532 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559908); (R-DRE-9940951)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58ICE4;A0AC58ICE6;A0AC58ICE7;A0AC58ICE9;A0AC58ICF5;A0AC58ICF6;A0AC58ICF8;A0AC58ICF9;A0AC58ICG0;A0AC58ICG1;A0AC58ICG2;A0AC58ICH7;A0AC58ICH8;A0AC58ICJ2;A0AC58ICJ8;F6NP92", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDD5-1", "uniprot_id": "A0A8M2BDD5_DANRE", "mass": 65951.0, "length": 584, "protein_name": "Transporter", "gene_name": "slc6a22.1", "organism": "Zebrafish", "refseq_name": "solute carrier family 6 member 22, tandem duplicate 1 isoform X1", "refseq_ac": "XP_005166076", "gene_names_uniprotkb": "slc6a22.1; si:ch211-263a23.7; si:zc263a23.7; slc6a13", "gene_names_refseq": "si:ch211-263a23.7; si:zc263a23.7; slc6a13; slc6a22.1", "protein_names_uniprotkb": "Transporter", "protein_names_refseq": "solute carrier family 6 member 22, tandem duplicate 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:368923); (R-DRE-352230); (R-DRE-442660); (R-DRE-888593)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "26180064;26469318;27453477;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BDD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFU1-1", "uniprot_id": "A0A8M2BFU1_DANRE", "mass": 70326.0, "length": 623, "protein_name": "Dystrobrevin", "gene_name": "dtnba", "organism": "Zebrafish", "refseq_name": "dystrobrevin, beta a isoform X1", "refseq_ac": "XP_005168583", "gene_names_uniprotkb": "dtnba; GDTN; dtnb; dtng; gtnb; wu:fc61h11", "gene_names_refseq": "GDTN; dtnba; dtnb; dtng; gtnb; wu:fc61h11", "protein_names_uniprotkb": "Dystrobrevin", "protein_names_refseq": "dystrobrevin, beta a isoform X1", "tax_id": 7955, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (dre:325242)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15520368;16109975;17233888;18042440;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168583.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BFU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B964-1", "uniprot_id": "A0A8M2B964_DANRE", "mass": 24402.0, "length": 225, "protein_name": "Tpd52 like 2b isoform X4", "gene_name": "tpd52l2b", "organism": "Zebrafish", "refseq_name": "tpd52 like 2b isoform X4", "refseq_ac": "XP_005162089", "gene_names_uniprotkb": "tpd52l2b; tpd52l2; wu:fb50b02; zgc:55294; zgc:77690", "gene_names_refseq": "tpd52l2b; tpd52l2; wu:fb50b02; zgc:55294; zgc:77690", "protein_names_uniprotkb": "Tpd52 like 2b isoform X4", "protein_names_refseq": "tpd52 like 2b isoform X4", "tax_id": 7955, "disease": "", "pathway": " (dre:322103)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;16109975;21468032;26469318;27189481;28252024;34185526", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2B964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9F5-1", "uniprot_id": "A0A8M2B9F5_DANRE", "mass": 176706.0, "length": 1659, "protein_name": "Polycomb group protein ASXL1 isoform 1", "gene_name": "asxl1", "organism": "Zebrafish", "refseq_name": "polycomb group protein ASXL1 isoform 1", "refseq_ac": "NP_001373383", "gene_names_uniprotkb": "asxl1; si:dkey-202m22.4", "gene_names_refseq": "asxl1; si:dkey-202m22.4", "protein_names_uniprotkb": "Polycomb group protein ASXL1 isoform 1", "protein_names_refseq": "additional sex combs like 1; additional sex combs like transcriptional regulator 1; polycomb group protein ASXL1 isoform 1", "tax_id": 7955, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); myeloproliferative neoplasm (Disease Ontology:DOID:2226); SM-AHNMD (Disease Ontology:DOID:4797); myelofibrosis (Disease Ontology:DOID:4971); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dre:403066)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "24240475;26469318;27189481;31064769;32522152;33483612;34735227;35918044;36804358", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01001754.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA3505370, SAMEA3505371 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On or before Aug 24, 2020 this sequence version replaced XP_005162395.1, XP_021329398.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)., [RefSeq]; Homozygous loss of asxl1 leads to apoptosis of newly formed hematopoietic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0061516 monocyte proliferation;GO:0045658 regulation of neutrophil differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2B9F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEH2-1", "uniprot_id": "A0A8M2BEH2_DANRE", "mass": 145979.0, "length": 1291, "protein_name": "PH_BCR_vertebrate and RhoGAP_Bcr domain-containing protein isoform X1", "gene_name": "si:dkey-91m11.5", "organism": "Zebrafish", "refseq_name": "PH_BCR_vertebrate and RhoGAP_Bcr domain-containing protein isoform X1", "refseq_ac": "XP_005167231", "gene_names_uniprotkb": "si:dkey-91m11.5", "gene_names_refseq": "si:dkey-91m11.5", "protein_names_uniprotkb": "PH_BCR_vertebrate and RhoGAP_Bcr domain-containing protein isoform X1", "protein_names_refseq": "PH_BCR_vertebrate and RhoGAP_Bcr domain-containing protein isoform X1", "tax_id": 7955, "disease": "leukemia (Disease Ontology:DOID:1240); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:560226)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G7I7", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0030424 axon;GO:0043197 dendritic spine", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BEH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBV2-1", "uniprot_id": "A0A8M2BBV2_DANRE", "mass": 158336.0, "length": 1385, "protein_name": "Pleckstrin homology domain-containing family A member 5 isoform X1", "gene_name": "plekha5", "organism": "Zebrafish", "refseq_name": "pleckstrin homology domain-containing family A member 5 isoform 1", "refseq_ac": "NP_001430043", "gene_names_uniprotkb": "plekha5; si:ch211-239h19.1; wu:fb16e08", "gene_names_refseq": "plekha5; si:ch211-239h19.1; wu:fb16e08", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 5 isoform X1", "protein_names_refseq": "pleckstrin homology domain-containing family A member 5 isoform 1", "tax_id": 7955, "disease": "", "pathway": " (dre:567300)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;23623870;26469318;27189481;28252024;28871129", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.21738986.1, SRR32588730.3104899.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000004.1. On Sep 5, 2025 this sequence version replaced XP_005164531.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BBV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEI3-1", "uniprot_id": "A0A8M2BEI3_DANRE", "mass": 56126.0, "length": 516, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "si:dkey-70p6.1", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005167109", "gene_names_uniprotkb": "si:dkey-70p6.1; si:ch211-215h12.6; zK70P6.1", "gene_names_refseq": "si:ch211-215h12.6; si:dkey-70p6.1; zK70P6.1", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570575)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0050868 negative regulation of T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BEI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBC3-1", "uniprot_id": "A0A8M2BBC3_DANRE", "mass": 57244.0, "length": 530, "protein_name": "ABI gene family member 3", "gene_name": "abi3a", "organism": "Zebrafish", "refseq_name": "ABI family, member 3a isoform X1", "refseq_ac": "XP_005164105", "gene_names_uniprotkb": "abi3a; zgc:153739", "gene_names_refseq": "abi3a; zgc:153739", "protein_names_uniprotkb": "ABI gene family member 3; New molecule including SH3", "protein_names_refseq": "ABI family, member 3a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:767807)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;26469318;26876635;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005164105.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0031209 SCAR complex;GO:0098858 actin-based cell projection", "go_biological_process": "GO:0002357 defense response to tumor cell;GO:0001764 neuron migration;GO:0048858 cell projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BBC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEP9-1", "uniprot_id": "A0A8M2BEP9_DANRE", "mass": 40245.0, "length": 359, "protein_name": "palmitoyl-CoA hydrolase", "gene_name": "acot7", "organism": "Zebrafish", "refseq_name": "cytosolic acyl coenzyme A thioester hydrolase isoform X1", "refseq_ac": "XP_005167330", "gene_names_uniprotkb": "acot7; zgc:103413", "gene_names_refseq": "acot7; zgc:103413", "protein_names_uniprotkb": "palmitoyl-CoA hydrolase; 3.1.2.2", "protein_names_refseq": "cytosolic acyl coenzyme A thioester hydrolase isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:447878)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27806254;28252024;34325655", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0009062 fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BEP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8M6-1", "uniprot_id": "A0A8M2B8M6_DANRE", "mass": 65871.0, "length": 604, "protein_name": "Transcription factor COE4", "gene_name": "ebf1b", "organism": "Zebrafish", "refseq_name": "transcription factor COE1-A-like isoform X1", "refseq_ac": "XP_005161480", "gene_names_uniprotkb": "ebf1b", "gene_names_refseq": "ebf1b", "protein_names_uniprotkb": "Transcription factor COE4; Early B-cell factor 4; Olf-1/EBF-like 4", "protein_names_refseq": "transcription factor COE1-A-like isoform X1", "tax_id": 7955, "disease": "lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (dre:557777)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005161480.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8M6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8K6-1", "uniprot_id": "A0A8M2B8K6_DANRE", "mass": 207190.0, "length": 1914, "protein_name": "InaD-like protein isoform X1", "gene_name": "patj", "organism": "Zebrafish", "refseq_name": "inaD-like protein isoform X1", "refseq_ac": "XP_073792405", "gene_names_uniprotkb": "patj; inadl; si:busm1-129i22.4; si:dz129i22.4; wu:fc76h08", "gene_names_refseq": "inadl; patj; si:busm1-129i22.4; si:dz129i22.4; wu:fc76h08", "protein_names_uniprotkb": "InaD-like protein isoform X1", "protein_names_refseq": "inaD-like protein isoform X1", "tax_id": 7955, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dre:368723)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11997341;26469318;27189481;28252024;29746212", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8QUA7;A0AC58IDT9;A0AC58IDU3;A0AC58IDU7;A0AC58IDU8;A0AC58IDV0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0120192 tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B8K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBB3-1", "uniprot_id": "A0A8M2BBB3_DANRE", "mass": 73152.0, "length": 670, "protein_name": "GTP-binding protein 1", "gene_name": "gtpbp1", "organism": "Zebrafish", "refseq_name": "GTP-binding protein 1 isoform X1", "refseq_ac": "XP_005164056", "gene_names_uniprotkb": "gtpbp1; cb858; wu:fb36e06; wu:fi39g05; zgc:66228", "gene_names_refseq": "cb858; gtpbp1; wu:fb36e06; wu:fi39g05; zgc:66228", "protein_names_uniprotkb": "GTP-binding protein 1; 3.6.5.3", "protein_names_refseq": "GTP-binding protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:378721)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15621534;16109975;17560942;20828405;24683187;26469318;27189481;28252024;34863900;36551964", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; GTPase that plays a role in the elongation phase of protein synthesis by forming ternary complexes with GTP and aminoacyl-transfer RNAs (aa-tRNAs), and delivering aa-tRNAs to the ribosomal A site in a GTP-dependent manner. Is also able to deliver deacylated tRNA to the A site. Additionally, it is involved in RNA quality control; after GTP hydrolysis, which is not immediately followed by rapid peptide bond formation, GTPBP1 likely retains aa-tRNA in the A site and promotes exosomal degradation of faulty mRNAs engaged in 80S elongation complexes. Plays a role in the regulation of circadian mRNA stability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BBB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B997-1", "uniprot_id": "A0A8M2B997_DANRE", "mass": 165926.0, "length": 1485, "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "usp19", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 19 isoform X1", "refseq_ac": "XP_005162175", "gene_names_uniprotkb": "usp19", "gene_names_refseq": "usp19", "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 19 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:324335)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162175.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA14-1", "uniprot_id": "A0A8M2BA14_DANRE", "mass": 126336.0, "length": 1138, "protein_name": "Solute carrier family 12 member 7 isoform X1", "gene_name": "slc12a7b", "organism": "Zebrafish", "refseq_name": "solute carrier family 12 member 7 isoform X1", "refseq_ac": "XP_005162967", "gene_names_uniprotkb": "slc12a7b", "gene_names_refseq": "slc12a7b", "protein_names_uniprotkb": "Solute carrier family 12 member 7 isoform X1", "protein_names_refseq": "solute carrier family 12 member 7 isoform X1", "tax_id": 7955, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:567667)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBM0-1", "uniprot_id": "A0A8M2BBM0_DANRE", "mass": 37718.0, "length": 326, "protein_name": "Carbonic anhydrase-related protein 10 isoform X1; Carbonic anhydrase-related protein 10 isoform X2", "gene_name": "ca10b", "organism": "Zebrafish", "refseq_name": "carbonic anhydrase-related protein 10 isoform X1", "refseq_ac": "XP_005164153", "gene_names_uniprotkb": "ca10b", "gene_names_refseq": "ca10b", "protein_names_uniprotkb": "Carbonic anhydrase-related protein 10 isoform X1; Carbonic anhydrase-related protein 10 isoform X2", "protein_names_refseq": "carbonic anhydrase-related protein 10 isoform X1", "tax_id": 7955, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (dre:568543)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Does not have a catalytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7EYF2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0016836 hydro-lyase activity", "go_cellular_component": "", "go_biological_process": "GO:0036269 swimming behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCJ8-1", "uniprot_id": "A0A8M2BCJ8_DANRE", "mass": 279509.0, "length": 2503, "protein_name": "ATP-binding cassette sub-family A member 2", "gene_name": "abca2", "organism": "Zebrafish", "refseq_name": "ATP-binding cassette sub-family A member 2 isoform X1", "refseq_ac": "XP_005165287", "gene_names_uniprotkb": "abca2", "gene_names_refseq": "abca2", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2", "protein_names_refseq": "ATP-binding cassette sub-family A member 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100006090)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005165287.1. COMPLETENESS: full length., [RefSeq]; Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis. May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0051247 positive regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCU1-1", "uniprot_id": "A0A8M2BCU1_DANRE", "mass": 73411.0, "length": 659, "protein_name": "Rhotekin isoform X1", "gene_name": "rtkna", "organism": "Zebrafish", "refseq_name": "rhotekin isoform X1", "refseq_ac": "XP_005165396", "gene_names_uniprotkb": "rtkna; si:dkey-40c11.1", "gene_names_refseq": "rtkna; si:dkey-40c11.1", "protein_names_uniprotkb": "Rhotekin isoform X1", "protein_names_refseq": "rhotekin isoform X1", "tax_id": 7955, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:564545)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27189481;35079792", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005826 actomyosin contractile ring", "go_biological_process": "GO:0007165 signal transduction;GO:0000281 mitotic cytokinesis;GO:0000915 actomyosin contractile ring assembly;GO:0031106 septin ring organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BCU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE66-1", "uniprot_id": "A0A8M2BE66_DANRE", "mass": 51015.0, "length": 470, "protein_name": "Apolipoprotein L6 isoform X1", "gene_name": "apold1b", "organism": "Zebrafish", "refseq_name": "apolipoprotein L6 isoform X1", "refseq_ac": "XP_001920639", "gene_names_uniprotkb": "apold1b", "gene_names_refseq": "apold1b", "protein_names_uniprotkb": "Apolipoprotein L6 isoform X1", "protein_names_refseq": "apolipoprotein L6 isoform X1", "tax_id": 7955, "disease": "substance abuse (Disease Ontology:DOID:302); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:100150119); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_001920639.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G2N7;E7F980", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BE66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE10-1", "uniprot_id": "A0A8M2BE10_DANRE", "mass": 98335.0, "length": 868, "protein_name": "Phosphodiesterase", "gene_name": "pde5ab", "organism": "Zebrafish", "refseq_name": "cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1", "refseq_ac": "XP_005166620", "gene_names_uniprotkb": "pde5ab; PDE5; pde5a", "gene_names_refseq": "PDE5; pde5ab; pde5a", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); pre-eclampsia (Disease Ontology:DOID:10591); primary biliary cholangitis (Disease Ontology:DOID:12236); impotence (Disease Ontology:DOID:1875); IgA glomerulonephritis (Disease Ontology:DOID:2986); vasculogenic impotence (Disease Ontology:DOID:4762); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:553270)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23033484;26469318;31654676", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.35", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BE10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFX4-1", "uniprot_id": "A0A8M2BFX4_DANRE", "mass": 107622.0, "length": 988, "protein_name": "DDB1- and CUL4-associated factor 6 isoform X1", "gene_name": "dcaf6", "organism": "Zebrafish", "refseq_name": "DDB1- and CUL4-associated factor 6 isoform X1", "refseq_ac": "XP_005167897", "gene_names_uniprotkb": "dcaf6; iqwd1; si:rp71-20i5.1", "gene_names_refseq": "dcaf6; iqwd1; si:rp71-20i5.1", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 6 isoform X1", "protein_names_refseq": "DDB1- and CUL4-associated factor 6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564498)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;26469318;27189481;31884103", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BFX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCP8-1", "uniprot_id": "A0A8M2BCP8_DANRE", "mass": 69339.0, "length": 624, "protein_name": "E3 SUMO-protein ligase PIAS2 isoform X1", "gene_name": "pias2", "organism": "Zebrafish", "refseq_name": "E3 SUMO-protein ligase PIAS2 isoform X1", "refseq_ac": "XP_005165453", "gene_names_uniprotkb": "pias2; piasx; wu:fi05f09", "gene_names_refseq": "pias2; piasx; wu:fi05f09", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS2 isoform X1", "protein_names_refseq": "E3 SUMO-protein ligase PIAS2 isoform X1", "tax_id": 7955, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (dre:564149)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15520368;22345667;22412924;28256502", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005165453.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016740 transferase activity;GO:0016874 ligase activity;GO:0061665 SUMO ligase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0060255 regulation of macromolecule metabolic process;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BCP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAF4-1", "uniprot_id": "A0A8M2BAF4_DANRE", "mass": 53017.0, "length": 475, "protein_name": "Aspartyl/asparaginyl beta-hydroxylase isoform X1", "gene_name": "asph", "organism": "Zebrafish", "refseq_name": "aspartyl/asparaginyl beta-hydroxylase isoform 3", "refseq_ac": "NP_001429552", "gene_names_uniprotkb": "asph; cb971; fb69e10; fc06d04; fc95a08; wu:fb69e10; wu:fc06d04; wu:fc95a08", "gene_names_refseq": "asph; cb971; fb69e10; fc06d04; fc95a08; wu:fb69e10; wu:fc06d04; wu:fc95a08", "protein_names_uniprotkb": "Aspartyl/asparaginyl beta-hydroxylase isoform X1", "protein_names_refseq": "aspartyl/asparaginyl beta-hydroxylase isoform 3; junctin", "tax_id": 7955, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (dre:323659)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20878432;23667590;26469318;28252024;32804943;35697689", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588725.35778738.1, SRR32588724.3040899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Aug 18, 2025 this sequence version replaced XP_005163439.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BAF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDH3-1", "uniprot_id": "A0A8M2BDH3_DANRE", "mass": 175032.0, "length": 1556, "protein_name": "Leucine-rich repeat-containing protein 7", "gene_name": "lrrc7", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat-containing protein 7 isoform X1", "refseq_ac": "XP_005166019", "gene_names_uniprotkb": "lrrc7", "gene_names_refseq": "lrrc7", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 7; Densin-180", "protein_names_refseq": "leucine-rich repeat-containing protein 7 isoform X1", "tax_id": 7955, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dre:566023)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0005912 adherens junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEG5-1", "uniprot_id": "A0A8M2BEG5_DANRE", "mass": 41933.0, "length": 383, "protein_name": "methenyltetrahydrofolate cyclohydrolase", "gene_name": "mthfd2l", "organism": "Zebrafish", "refseq_name": "probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1", "refseq_ac": "XP_005167203", "gene_names_uniprotkb": "mthfd2l; wu:fi14c12; zgc:63479", "gene_names_refseq": "mthfd2l; wu:fi14c12; zgc:63479", "protein_names_uniprotkb": "methenyltetrahydrofolate cyclohydrolase; 3.5.4.9", "protein_names_refseq": "probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005167203.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.9;6.3.4.3;1.5.1.5", "go_molecular_function": "GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0006760 folic acid-containing compound metabolic process;GO:0035999 tetrahydrofolate interconversion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEH5-1", "uniprot_id": "A0A8M2BEH5_DANRE", "mass": 24070.0, "length": 219, "protein_name": "Tpd52 like 2a isoform X1", "gene_name": "tpd52l2a", "organism": "Zebrafish", "refseq_name": "tpd52 like 2a isoform X1", "refseq_ac": "XP_005167067", "gene_names_uniprotkb": "tpd52l2a; fk69c03; wu:fc29c04; wu:fk69c03; zgc:55624; zgc:77795", "gene_names_refseq": "fk69c03; tpd52l2a; wu:fc29c04; wu:fk69c03; zgc:55624; zgc:77795", "protein_names_uniprotkb": "Tpd52 like 2a isoform X1", "protein_names_refseq": "tpd52 like 2a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:335107)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21468032;26469318;27189481;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BEH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE84-1", "uniprot_id": "A0A8M2BE84_DANRE", "mass": 90406.0, "length": 811, "protein_name": "Small conductance calcium-activated potassium channel protein 1b isoform X1", "gene_name": "kcnn1b", "organism": "Zebrafish", "refseq_name": "small conductance calcium-activated potassium channel protein 1b isoform 3", "refseq_ac": "NP_001429511", "gene_names_uniprotkb": "kcnn1b; kcnn1; si:ch211-200a16.1; sk1", "gene_names_refseq": "kcnn1b; kcnn1; si:ch211-200a16.1; sk1", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 1b isoform X1", "protein_names_refseq": "potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; small conductance calcium-activated potassium channel protein 1b isoform 3", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "22412924;24060674;26469318;27189481;29412518;32841905;33203744;33728688", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588717.56522943.1, SRR32588730.6264997.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1., [RefSeq]; The expression and the distribution of SK1 in the peripheral nervous system and sensory organs of adult zebrafish, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0016286 small conductance calcium-activated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0030018 Z disc", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2BE84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBF3-1", "uniprot_id": "A0A8M2BBF3_DANRE", "mass": 117752.0, "length": 1044, "protein_name": "Protein CLEC16A isoform X1", "gene_name": "clec16a", "organism": "Zebrafish", "refseq_name": "protein CLEC16A isoform X1", "refseq_ac": "XP_005163973", "gene_names_uniprotkb": "clec16a", "gene_names_refseq": "clec16a", "protein_names_uniprotkb": "Protein CLEC16A isoform X1", "protein_names_refseq": "protein CLEC16A isoform X1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Addison's disease (Disease Ontology:DOID:13774); multiple sclerosis (Disease Ontology:DOID:2377); rheumatoid arthritis (Disease Ontology:DOID:7148); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:393184)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0010506 regulation of autophagy;GO:1901524 regulation of mitophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFD5-1", "uniprot_id": "A0A8M2BFD5_DANRE", "mass": 112737.0, "length": 1052, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "aak1a", "organism": "Zebrafish", "refseq_name": "AP2-associated protein kinase 1 isoform X1", "refseq_ac": "XP_005167369", "gene_names_uniprotkb": "aak1a", "gene_names_refseq": "aak1a", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "AP2-associated protein kinase 1 isoform X1", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:568999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBU7-1", "uniprot_id": "A0A8M2BBU7_DANRE", "mass": 52551.0, "length": 460, "protein_name": "Uncharacterized protein ccdc136b isoform X1", "gene_name": "ccdc136a; ccdc136b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein ccdc136b isoform X1", "refseq_ac": "XP_005164664", "gene_names_uniprotkb": "ccdc136a; ccdc136b; ccdc136a", "gene_names_refseq": "ccdc136b", "protein_names_uniprotkb": "Uncharacterized protein ccdc136b isoform X1", "protein_names_refseq": "uncharacterized protein ccdc136b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100321715); (dre:100330186)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0030178 negative regulation of Wnt signaling pathway;GO:0007338 single fertilization;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCE4-1", "uniprot_id": "A0A8M2BCE4_DANRE", "mass": 38957.0, "length": 342, "protein_name": "Chemerin-like receptor 1", "gene_name": "cmklr1l1; cmklrl2", "organism": "Zebrafish", "refseq_name": "chemerin-like receptor 1", "refseq_ac": "XP_005165256", "gene_names_uniprotkb": "cmklr1l1; cmklrl2", "gene_names_refseq": "cmklrl2", "protein_names_uniprotkb": "Chemerin-like receptor 1", "protein_names_refseq": "chemerin-like receptor 1", "tax_id": 7955, "disease": "dentin caries (Disease Ontology:DOID:10461)", "pathway": " (dre:795295); (dre:795365); (R-DRE-373076); (R-DRE-416476); (R-DRE-418594); (R-DRE-444473); (R-DRE-6798695)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAL0-1", "uniprot_id": "A0A8M2BAL0_DANRE", "mass": 128523.0, "length": 1154, "protein_name": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1", "gene_name": "asap1a", "organism": "Zebrafish", "refseq_name": "arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1", "refseq_ac": "XP_005163531", "gene_names_uniprotkb": "asap1a; si:ch211-160i2.3", "gene_names_refseq": "asap1a; si:ch211-160i2.3", "protein_names_uniprotkb": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1", "protein_names_refseq": "arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0002102 podosome", "go_biological_process": "GO:1905523 positive regulation of macrophage migration;GO:0042742 defense response to bacterium;GO:0060271 cilium assembly;GO:1903527 positive regulation of membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8W4-1", "uniprot_id": "A0A8M2B8W4_DANRE", "mass": 396557.0, "length": 3411, "protein_name": "Abnormal spindle-like microcephaly-associated protein isoform X1", "gene_name": "aspm", "organism": "Zebrafish", "refseq_name": "abnormal spindle-like microcephaly-associated protein isoform X1", "refseq_ac": "XP_005161794", "gene_names_uniprotkb": "aspm; fc13b04; si:dkey-114d20.4; wu:fc13b04", "gene_names_refseq": "aspm; fc13b04; si:dkey-114d20.4; wu:fc13b04", "protein_names_uniprotkb": "Abnormal spindle-like microcephaly-associated protein isoform X1", "protein_names_refseq": "abnormal spindle-like microcephaly-associated protein isoform X1", "tax_id": 7955, "disease": "primary autosomal recessive microcephaly 5 (Disease Ontology:DOID:0070280); autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); stomach cancer (Disease Ontology:DOID:10534); microcephaly (Disease Ontology:DOID:10907); ovary epithelial cancer (Disease Ontology:DOID:2152); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dre:554173)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12234666;16089502;19278998;21620798;24153002;28985365;31696992;32467236;39496611", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007051 spindle organization;GO:0051295 establishment of meiotic spindle localization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2B8W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDY2-1", "uniprot_id": "A0A8M2BDY2_DANRE", "mass": 55324.0, "length": 491, "protein_name": "Limb region 1 protein homolog isoform X1", "gene_name": "lmbr1", "organism": "Zebrafish", "refseq_name": "limb region 1 protein homolog isoform X1", "refseq_ac": "XP_005166487", "gene_names_uniprotkb": "lmbr1; im:7156444", "gene_names_refseq": "im:7156444; lmbr1", "protein_names_uniprotkb": "Limb region 1 protein homolog isoform X1", "protein_names_refseq": "limb region 1 protein homolog isoform X1", "tax_id": 7955, "disease": "acheiropody (Disease Ontology:DOID:0050603); preaxial polydactyly II (Disease Ontology:DOID:0060986); bone development disease (Disease Ontology:DOID:0080006); Laurin-Sandrow syndrome (Disease Ontology:DOID:0111350); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818)", "pathway": " (dre:557300)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27189481;29228146;32106888", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BDY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFK7-1", "uniprot_id": "A0A8M2BFK7_DANRE", "mass": 23289.0, "length": 208, "protein_name": "Clathrin light chain", "gene_name": "cltb", "organism": "Zebrafish", "refseq_name": "clathrin light chain B isoform X2", "refseq_ac": "XP_005168280", "gene_names_uniprotkb": "cltb", "gene_names_refseq": "cltb", "protein_names_uniprotkb": "Clathrin light chain", "protein_names_refseq": "clathrin light chain B isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:100329879); (R-DRE-196025); (R-DRE-5099900)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0030130 clathrin coat of trans-Golgi network vesicle;GO:0030132 clathrin coat of coated pit", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEZ3-1", "uniprot_id": "A0A8M2BEZ3_DANRE", "mass": 90433.0, "length": 802, "protein_name": "Rho guanine nucleotide exchange factor 7a isoform X5", "gene_name": "arhgef7a", "organism": "Zebrafish", "refseq_name": "rho guanine nucleotide exchange factor 7a isoform X5", "refseq_ac": "XP_005167621", "gene_names_uniprotkb": "arhgef7a; fc28d09; wu:fc28d09", "gene_names_refseq": "arhgef7a; fc28d09; wu:fc28d09", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 7a isoform X5", "protein_names_refseq": "rho guanine nucleotide exchange factor 7a isoform X5", "tax_id": 7955, "disease": "", "pathway": " (dre:553493)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15520368;16408288;20405038;26582102;27046191;27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0030027 lamellipodium;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2BEZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAK6-1", "uniprot_id": "A0A8M2BAK6_DANRE", "mass": 104758.0, "length": 942, "protein_name": "Helicase-like transcription factor isoform X1", "gene_name": "hltf", "organism": "Zebrafish", "refseq_name": "helicase-like transcription factor isoform X1", "refseq_ac": "XP_005163433", "gene_names_uniprotkb": "hltf", "gene_names_refseq": "hltf", "protein_names_uniprotkb": "Helicase-like transcription factor isoform X1", "protein_names_refseq": "helicase-like transcription factor isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564651); (R-DRE-8866654)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0V118", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0004386 helicase activity;GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BET3-1", "uniprot_id": "A0A8M2BET3_DANRE", "mass": 364887.0, "length": 3236, "protein_name": "Intermembrane lipid transfer protein VPS13A isoform X1", "gene_name": "vps13a", "organism": "Zebrafish", "refseq_name": "intermembrane lipid transfer protein VPS13A isoform 1", "refseq_ac": "NP_001429275", "gene_names_uniprotkb": "vps13a; chac; wu:fc10c04", "gene_names_refseq": "chac; vps13a; wu:fc10c04", "protein_names_uniprotkb": "Intermembrane lipid transfer protein VPS13A isoform X1", "protein_names_refseq": "intermembrane lipid transfer protein VPS13A isoform 1", "tax_id": 7955, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); choreaacanthocytosis (Disease Ontology:DOID:0050766); Parkinson's disease 23 (Disease Ontology:DOID:0060896); Cohen syndrome (Disease Ontology:DOID:0111590); autosomal recessive spinocerebellar ataxia 4 (Disease Ontology:DOID:0111611); choreatic disease (Disease Ontology:DOID:12859); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:378837)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12368263;26469318;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01043098.1, SRR26395062.1820245.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Aug 1, 2025 this sequence version replaced XP_005167391.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006869 lipid transport;GO:0045053 protein retention in Golgi apparatus;GO:0006914 autophagy;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BET3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9H0-1", "uniprot_id": "A0A8M2B9H0_DANRE", "mass": 78457.0, "length": 713, "protein_name": "Cyclin-T1 isoform X1", "gene_name": "ccnt1", "organism": "Zebrafish", "refseq_name": "cyclin-T1 isoform X1", "refseq_ac": "XP_005162427", "gene_names_uniprotkb": "ccnt1; fi75b02; si:dkey-18f23.10; wu:fi75b02", "gene_names_refseq": "ccnt1; fi75b02; si:dkey-18f23.10; wu:fi75b02", "protein_names_uniprotkb": "Cyclin-T1 isoform X1", "protein_names_refseq": "cyclin-T1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:334465)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;31183407;37079685", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162427.1. COMPLETENESS: full length., [RefSeq]; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032786 positive regulation of DNA-templated transcription, elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B9H0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8R9-1", "uniprot_id": "A0A8M2B8R9_DANRE", "mass": 54585.0, "length": 486, "protein_name": "Amphoterin-induced protein 3 isoform X1", "gene_name": "amigo3", "organism": "Zebrafish", "refseq_name": "amphoterin-induced protein 3 isoform X1", "refseq_ac": "XP_005161898", "gene_names_uniprotkb": "amigo3", "gene_names_refseq": "amigo3", "protein_names_uniprotkb": "Amphoterin-induced protein 3 isoform X1", "protein_names_refseq": "amphoterin-induced protein 3 isoform X1", "tax_id": 7955, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (dre:100000131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005161898.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCG7-1", "uniprot_id": "A0A8M2BCG7_DANRE", "mass": 49561.0, "length": 479, "protein_name": "EMI domain-containing protein 1 isoform X1", "gene_name": "emid1", "organism": "Zebrafish", "refseq_name": "EMI domain-containing protein 1 isoform X1", "refseq_ac": "XP_005165282", "gene_names_uniprotkb": "emid1", "gene_names_refseq": "emid1", "protein_names_uniprotkb": "EMI domain-containing protein 1 isoform X1", "protein_names_refseq": "EMI domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "skin disease (Disease Ontology:DOID:37)", "pathway": " (dre:797252)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEZ8-1", "uniprot_id": "A0A8M2BEZ8_DANRE", "mass": 45033.0, "length": 403, "protein_name": "Atypical chemokine receptor 3a isoform X1", "gene_name": "ackr3a", "organism": "Zebrafish", "refseq_name": "atypical chemokine receptor 3a isoform X1", "refseq_ac": "XP_005167578", "gene_names_uniprotkb": "ackr3a; cxcr7a; cxcr7b; drRDC1a; si:dkey-191g15.12; si:dkeyp-74a11.11", "gene_names_refseq": "ackr3a; cxcr7a; cxcr7b; drRDC1a; si:dkey-191g15.12; si:dkeyp-74a11.11", "protein_names_uniprotkb": "Atypical chemokine receptor 3a isoform X1", "protein_names_refseq": "atypical chemokine receptor 3a isoform X1", "tax_id": 7955, "disease": "laryngeal carcinoma (Disease Ontology:DOID:2600); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (dre:100000764)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16365434;17537794;21258340;23145839;23382464;31156639;31349731;31529512;33330448;34716527", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0015026 coreceptor activity;GO:0019956 chemokine binding;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006935 chemotaxis;GO:0048920 posterior lateral line neuromast primordium migration;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BEZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8S3-1", "uniprot_id": "A0A8M2B8S3_DANRE", "mass": 199009.0, "length": 1793, "protein_name": "Microtubule cross-linking factor 2 isoform X1", "gene_name": "mtcl2", "organism": "Zebrafish", "refseq_name": "microtubule cross-linking factor 2 isoform X1", "refseq_ac": "XP_005162024", "gene_names_uniprotkb": "mtcl2", "gene_names_refseq": "mtcl2", "protein_names_uniprotkb": "Microtubule cross-linking factor 2 isoform X1", "protein_names_refseq": "microtubule cross-linking factor 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:797906)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162024.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGA5-1", "uniprot_id": "A0A8M2BGA5_DANRE", "mass": 330411.0, "length": 2952, "protein_name": "Chromodomain-helicase-DNA-binding protein 9 isoform X1", "gene_name": "chd9", "organism": "Zebrafish", "refseq_name": "chromodomain-helicase-DNA-binding protein 9 isoform X1", "refseq_ac": "XP_005169069", "gene_names_uniprotkb": "chd9", "gene_names_refseq": "chd9", "protein_names_uniprotkb": "Chromodomain-helicase-DNA-binding protein 9 isoform X1", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 9 isoform X1", "tax_id": 7955, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dre:572355)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005169069.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.-;2.3.2.27;3.6.4.-;4.2.99.18;5.6.2.4;5.6.2.3;3.6.4.12;3.6.4.13;2.7.4.3;7.6.2.2;5.6.1.6;7.6.2.3;3.6.1.5;3.6.4.6;3.6.1.15;3.6.4.10;5.6.2.-;2.7.7.7;2.7.7.49;5.6.2.5;3.6.5.-;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003682 chromatin binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0006338 chromatin remodeling;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEF8-1", "uniprot_id": "A0A8M2BEF8_DANRE", "mass": 106499.0, "length": 949, "protein_name": "Centrosomal protein of 104 kDa", "gene_name": "cep104", "organism": "Zebrafish", "refseq_name": "centrosomal protein of 104 kDa isoform X1", "refseq_ac": "XP_005167010", "gene_names_uniprotkb": "cep104", "gene_names_refseq": "cep104", "protein_names_uniprotkb": "Centrosomal protein of 104 kDa", "protein_names_refseq": "centrosomal protein of 104 kDa isoform X1", "tax_id": 7955, "disease": "autosomal recessive intellectual developmental disorder 77 (Disease Ontology:DOID:0081236); Joubert syndrome 25 (Disease Ontology:DOID:0110994)", "pathway": " (dre:560451)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_005167010.1. COMPLETENESS: full length., [RefSeq]; Required for ciliogenesis and for structural integrity at the ciliary tip., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005929 cilium;GO:0005814 centriole", "go_biological_process": "GO:0021545 cranial nerve development;GO:0060271 cilium assembly;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBQ2-1", "uniprot_id": "A0A8M2BBQ2_DANRE", "mass": 34735.0, "length": 309, "protein_name": "Uncharacterized protein si:ch73-278m9.1 isoform X1", "gene_name": "si:ch73-278m9.1", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:ch73-278m9.1 isoform X1", "refseq_ac": "XP_005164520", "gene_names_uniprotkb": "si:ch73-278m9.1", "gene_names_refseq": "si:ch73-278m9.1", "protein_names_uniprotkb": "Uncharacterized protein si:ch73-278m9.1 isoform X1", "protein_names_refseq": "uncharacterized protein si:ch73-278m9.1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100334203)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0034394 protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAH5-1", "uniprot_id": "A0A8M2BAH5_DANRE", "mass": 200806.0, "length": 1827, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "ptprz1a", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase zeta isoform X1", "refseq_ac": "XP_005163194", "gene_names_uniprotkb": "ptprz1a", "gene_names_refseq": "ptprz1a", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase zeta isoform X1", "tax_id": 7955, "disease": "status epilepticus (Disease Ontology:DOID:1824); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (dre:497461)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005163194.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.27;3.1.3.21", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0031175 neuron projection development;GO:0048709 oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEN6-1", "uniprot_id": "A0A8M2BEN6_DANRE", "mass": 33438.0, "length": 291, "protein_name": "Syntaxin-2 isoform X2", "gene_name": "stx2b", "organism": "Zebrafish", "refseq_name": "syntaxin-2 isoform X2", "refseq_ac": "XP_005167314", "gene_names_uniprotkb": "stx2b", "gene_names_refseq": "stx2b", "protein_names_uniprotkb": "Syntaxin-2 isoform X2", "protein_names_refseq": "syntaxin-2 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:100536636)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031201 SNARE complex;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0048278 vesicle docking;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B866-1", "uniprot_id": "A0A8M2B866_DANRE", "mass": 139186.0, "length": 1290, "protein_name": "Nuclear factor related to kappa-B-binding protein", "gene_name": "nfrkb", "organism": "Zebrafish", "refseq_name": "nuclear factor related to kappa-B-binding protein", "refseq_ac": "NP_001229964", "gene_names_uniprotkb": "nfrkb; fi86h10; si:dkey-92k1.11; wu:fi86h10", "gene_names_refseq": "fi86h10; nfrkb; si:dkey-92k1.11; wu:fi86h10", "protein_names_uniprotkb": "Nuclear factor related to kappa-B-binding protein; DNA-binding protein R kappa-B", "protein_names_refseq": "nuclear factor related to kappa-B-binding protein", "tax_id": 7955, "disease": "", "pathway": " (dre:567709); (R-DRE-5689603); (R-DRE-5696394)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "26469318;27773705;33933422;34315984", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC054902.1, SRR32588729.31782219.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IL86", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0031011 Ino80 complex", "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0010604 positive regulation of macromolecule metabolic process;GO:0051052 regulation of DNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2B866-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8B7-1", "uniprot_id": "A0A8M2B8B7_DANRE", "mass": 74893.0, "length": 663, "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "hif1al2", "organism": "Zebrafish", "refseq_name": "hypoxia inducible factor 1 subunit alpha, like 2", "refseq_ac": "NP_001012371", "gene_names_uniprotkb": "hif1al2; hif1al; zgc:112119", "gene_names_refseq": "hif1al2; hif1al; zgc:112119", "protein_names_uniprotkb": "Hypoxia-inducible factor 1-alpha", "protein_names_refseq": "HIF3B; Hif2a; hypoxia inducible factor 1 subunit alpha, like 2; hypoxia-inducible factor 1, alpha subunit, like 2", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:497283); (R-DRE-1234158); (R-DRE-1234176); (R-DRE-8951664)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "15621534;19449054;20952382;21343420;23461336;32784920;33123006;35758696;37290634;38850536", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC093209.1, GFIL01012518.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On Jun 25, 2025 this sequence version replaced NP_001012371.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Prominent changes were seen for Hif-2alpha expression, which significantly increased after the first day of exercise and then decreased down to values significantly below control values., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1QQQ1", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0071456 cellular response to hypoxia;GO:0048513 animal organ development;GO:0032364 intracellular oxygen homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2B8B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8E1-1", "uniprot_id": "A0A8M2B8E1_DANRE", "mass": 112009.0, "length": 1007, "protein_name": "DENN domain-containing protein 1A isoform X1", "gene_name": "dennd1a", "organism": "Zebrafish", "refseq_name": "DENN domain-containing protein 1A isoform X1", "refseq_ac": "XP_005161553", "gene_names_uniprotkb": "dennd1a", "gene_names_refseq": "dennd1a", "protein_names_uniprotkb": "DENN domain-containing protein 1A isoform X1", "protein_names_refseq": "DENN domain-containing protein 1A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556150)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0030136 clathrin-coated vesicle;GO:0005829 cytosol", "go_biological_process": "GO:0006897 endocytosis;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8E1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8C7-1", "uniprot_id": "A0A8M2B8C7_DANRE", "mass": 71973.0, "length": 647, "protein_name": "Rho GTPase-activating protein 24 isoform X1", "gene_name": "si:ch211-247j9.1", "organism": "Zebrafish", "refseq_name": "rho GTPase-activating protein 24 isoform X1", "refseq_ac": "XP_005161458", "gene_names_uniprotkb": "si:ch211-247j9.1", "gene_names_refseq": "si:ch211-247j9.1", "protein_names_uniprotkb": "Rho GTPase-activating protein 24 isoform X1", "protein_names_refseq": "rho GTPase-activating protein 24 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570019)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005161458.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005925 focal adhesion", "go_biological_process": "GO:1900028 negative regulation of ruffle assembly;GO:0007165 signal transduction;GO:0035313 wound healing, spreading of epidermal cells;GO:0035021 negative regulation of Rac protein signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8H5-1", "uniprot_id": "A0A8M2B8H5_DANRE", "mass": 20293.0, "length": 189, "protein_name": "Claudin", "gene_name": "cldn28", "organism": "Zebrafish", "refseq_name": "claudin-like protein ZF-A89", "refseq_ac": "XP_005161336", "gene_names_uniprotkb": "cldn28", "gene_names_refseq": "cldn28", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "claudin-like protein ZF-A89", "tax_id": 7955, "disease": "peptic esophagitis (Disease Ontology:DOID:13976); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (dre:796314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B905-1", "uniprot_id": "A0A8M2B905_DANRE", "mass": 60111.0, "length": 520, "protein_name": "Rho guanine nucleotide exchange factor 3", "gene_name": "arhgef3", "organism": "Zebrafish", "refseq_name": "rho guanine nucleotide exchange factor 3 isoform X1", "refseq_ac": "XP_005161924", "gene_names_uniprotkb": "arhgef3; si:ch211-258l4.8", "gene_names_refseq": "arhgef3; si:ch211-258l4.8", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 3", "protein_names_refseq": "rho guanine nucleotide exchange factor 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570228)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21715309;22139419;24683187;26469318;26595314;27189481;32959503", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005161924.1. COMPLETENESS: full length., [RefSeq]; Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030097 hemopoiesis;GO:0061515 myeloid cell development;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2B905-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8Q7-1", "uniprot_id": "A0A8M2B8Q7_DANRE", "mass": 99707.0, "length": 884, "protein_name": "Sentrin-specific protease 7b isoform X1", "gene_name": "senp7b", "organism": "Zebrafish", "refseq_name": "sentrin-specific protease 7b isoform X1", "refseq_ac": "XP_005161832", "gene_names_uniprotkb": "senp7b; fc07g08; senp7; si:ch211-239j15.4; si:dkey-21o6.1; wu:fc07g08", "gene_names_refseq": "fc07g08; senp7b; senp7; si:ch211-239j15.4; si:dkey-21o6.1; wu:fc07g08", "protein_names_uniprotkb": "Sentrin-specific protease 7b isoform X1", "protein_names_refseq": "sentrin-specific protease 7b isoform X1", "tax_id": 7955, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318)", "pathway": " (dre:100006377)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25534026;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070139 SUMO-specific endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016926 protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2B8Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8T1-1", "uniprot_id": "A0A8M2B8T1_DANRE", "mass": 62479.0, "length": 555, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-3", "gene_name": "cacnb3a", "organism": "Zebrafish", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-3a isoform X1", "refseq_ac": "XP_005162051", "gene_names_uniprotkb": "cacnb3a; cacnb3", "gene_names_refseq": "cacnb3a; cacnb3", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-3; Calcium channel voltage-dependent subunit beta 3", "protein_names_refseq": "voltage-dependent L-type calcium channel subunit beta-3a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008331 high voltage-gated calcium channel activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8T5-1", "uniprot_id": "A0A8M2B8T5_DANRE", "mass": 44837.0, "length": 400, "protein_name": "Serine and arginine rich splicing factor 6a isoform X1", "gene_name": "srsf6a", "organism": "Zebrafish", "refseq_name": "serine and arginine rich splicing factor 6a isoform X1", "refseq_ac": "XP_005161979", "gene_names_uniprotkb": "srsf6a; fa12h12; sfrs6a; wu:fa12h12; wu:fa13e06; zgc:63770", "gene_names_refseq": "fa12h12; sfrs6a; srsf6a; wu:fa12h12; wu:fa13e06; zgc:63770", "protein_names_uniprotkb": "Serine and arginine rich splicing factor 6a isoform X1", "protein_names_refseq": "serine and arginine rich splicing factor 6a isoform X1", "tax_id": 7955, "disease": "spermatogenic failure 3 (Disease Ontology:DOID:0070168); Huntington's disease (Disease Ontology:DOID:12858); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); lung cancer (Disease Ontology:DOID:1324); colon adenocarcinoma (Disease Ontology:DOID:234); skin cancer (Disease Ontology:DOID:4159); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0048514 blood vessel morphogenesis;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8T6-1", "uniprot_id": "A0A8M2B8T6_DANRE", "mass": 90797.0, "length": 802, "protein_name": "Zinc finger protein 512B isoform X1", "gene_name": "znf512b", "organism": "Zebrafish", "refseq_name": "zinc finger protein 512B isoform X1", "refseq_ac": "XP_005162061", "gene_names_uniprotkb": "znf512b", "gene_names_refseq": "znf512b", "protein_names_uniprotkb": "Zinc finger protein 512B isoform X1", "protein_names_refseq": "zinc finger protein 512B isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101885988)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8T6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8V1-1", "uniprot_id": "A0A8M2B8V1_DANRE", "mass": 54297.0, "length": 473, "protein_name": "Oxysterol-binding protein", "gene_name": "osbpl2b", "organism": "Zebrafish", "refseq_name": "oxysterol-binding protein-related protein 2b isoform X1", "refseq_ac": "XP_005162004", "gene_names_uniprotkb": "osbpl2b; Osbpl1a; osbpl2; wu:fi36a04; zgc:55948", "gene_names_refseq": "Osbpl1a; osbpl2b; osbpl2; wu:fi36a04; zgc:55948", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "oxysterol-binding protein-related protein 2b isoform X1", "tax_id": 7955, "disease": "autosomal dominant nonsyndromic deafness 67 (Disease Ontology:DOID:0110588); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dre:334206)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162004.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8W3-1", "uniprot_id": "A0A8M2B8W3_DANRE", "mass": 60662.0, "length": 532, "protein_name": "Rho guanine nucleotide exchange factor 3", "gene_name": "arhgef3l", "organism": "Zebrafish", "refseq_name": "rho guanine nucleotide exchange factor (GEF) 3, like isoform X1", "refseq_ac": "XP_005162130", "gene_names_uniprotkb": "arhgef3l; zgc:109904", "gene_names_refseq": "arhgef3l; zgc:109904", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 3", "protein_names_refseq": "rho guanine nucleotide exchange factor (GEF) 3, like isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B8Z0-1", "uniprot_id": "A0A8M2B8Z0_DANRE", "mass": 46431.0, "length": 405, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "usp21", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 21 isoform X1", "refseq_ac": "XP_005162186", "gene_names_uniprotkb": "usp21", "gene_names_refseq": "usp21", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 21 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563546)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0021551 central nervous system morphogenesis;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B8Z0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B906-1", "uniprot_id": "A0A8M2B906_DANRE", "mass": 44685.0, "length": 415, "protein_name": "Regulator of complement activation group 2 gene 1 isoform X1", "gene_name": "rca2.1", "organism": "Zebrafish", "refseq_name": "regulator of complement activation group 2 gene 1 isoform X1", "refseq_ac": "XP_005162222", "gene_names_uniprotkb": "rca2.1; tecrem; wu:fb99a10; wu:fj86g12; zgc:110775", "gene_names_refseq": "rca2.1; tecrem; wu:fb99a10; wu:fj86g12; zgc:110775", "protein_names_uniprotkb": "Regulator of complement activation group 2 gene 1 isoform X1", "protein_names_refseq": "regulator of complement activation group 2 gene 1 isoform X1", "tax_id": 7955, "disease": "COVID-19 (Disease Ontology:DOID:0080600); prostate cancer (Disease Ontology:DOID:10283); protein-losing enteropathy (Disease Ontology:DOID:10611); breast cancer (Disease Ontology:DOID:1612); endometrial adenocarcinoma (Disease Ontology:DOID:2870); cervical cancer (Disease Ontology:DOID:4362)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B906-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B931-1", "uniprot_id": "A0A8M2B931_DANRE", "mass": 128172.0, "length": 1144, "protein_name": "DNA mismatch repair protein Mlh3 isoform X1", "gene_name": "mlh3", "organism": "Zebrafish", "refseq_name": "DNA mismatch repair protein Mlh3 isoform X1", "refseq_ac": "XP_005162267", "gene_names_uniprotkb": "mlh3", "gene_names_refseq": "mlh3", "protein_names_uniprotkb": "DNA mismatch repair protein Mlh3 isoform X1", "protein_names_refseq": "DNA mismatch repair protein Mlh3 isoform X1", "tax_id": 7955, "disease": "hereditary nonpolyposis colorectal cancer type 7 (Disease Ontology:DOID:0070276); endometrial cancer (Disease Ontology:DOID:1380); Lynch syndrome (Disease Ontology:DOID:3883); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:568323)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162267.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032300 mismatch repair complex", "go_biological_process": "GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9C1-1", "uniprot_id": "A0A8M2B9C1_DANRE", "mass": 38180.0, "length": 336, "protein_name": "Regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1", "gene_name": "rprd1b", "organism": "Zebrafish", "refseq_name": "regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1", "refseq_ac": "XP_005162475", "gene_names_uniprotkb": "rprd1b; fb23h08; wu:fb23h08; zgc:55687", "gene_names_refseq": "fb23h08; rprd1b; wu:fb23h08; zgc:55687", "protein_names_uniprotkb": "Regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1", "protein_names_refseq": "regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15256591;26469318;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IIP9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0099122 RNA polymerase II C-terminal domain binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001111 RNA polymerase II promoter clearance;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2B9C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9E0-1", "uniprot_id": "A0A8M2B9E0_DANRE", "mass": 546269.0, "length": 4958, "protein_name": "Histone-lysine N-methyltransferase 2C", "gene_name": "kmt2ca", "organism": "Zebrafish", "refseq_name": "histone-lysine N-methyltransferase 2C isoform X1", "refseq_ac": "XP_005162602", "gene_names_uniprotkb": "kmt2ca", "gene_names_refseq": "kmt2ca", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase 2C; 2.1.1.364", "protein_names_refseq": "histone-lysine N-methyltransferase 2C isoform X1", "tax_id": 7955, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); Kleefstra syndrome 2 (Disease Ontology:DOID:0080598); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); squamous cell carcinoma (Disease Ontology:DOID:1749); laryngeal carcinoma (Disease Ontology:DOID:2600); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); Klatskin's tumor (Disease Ontology:DOID:4927); stomach carcinoma (Disease Ontology:DOID:5517); rheumatoid arthritis (Disease Ontology:DOID:7148); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dre:560793)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162602.1. COMPLETENESS: full length., [RefSeq]; Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.364", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0016746 acyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2B9E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9G9-1", "uniprot_id": "A0A8M2B9G9_DANRE", "mass": 46411.0, "length": 417, "protein_name": "Atypical chemokine receptor 4b", "gene_name": "ackr4b", "organism": "Zebrafish", "refseq_name": "atypical chemokine receptor 4b", "refseq_ac": "NP_001373522", "gene_names_uniprotkb": "ackr4b; ccrl1b; sb:eu250", "gene_names_refseq": "ackr4b; ccrl1b; sb:eu250", "protein_names_uniprotkb": "Atypical chemokine receptor 4b", "protein_names_refseq": "atypical chemokine receptor 4b; chemokine (C-C motif) receptor-like 1b; drCCRL1b; zfCCRL1-2", "tax_id": 7955, "disease": "", "pathway": " (dre:641390)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16365434;19022503;23145839;26469318;27189481;28096348;28351983;31529512", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC155663.1, GFIL01022563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505374 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000024.1. On or before Aug 29, 2020 this sequence version replaced XP_021329417.1, XP_005162666.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2B9G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9H4-1", "uniprot_id": "A0A8M2B9H4_DANRE", "mass": 35177.0, "length": 306, "protein_name": "Zinc finger protein 740", "gene_name": "znf740b", "organism": "Zebrafish", "refseq_name": "zinc finger protein 740b isoform X1", "refseq_ac": "XP_005162447", "gene_names_uniprotkb": "znf740b; zgc:153696; znf740", "gene_names_refseq": "zgc:153696; znf740b; znf740", "protein_names_uniprotkb": "Zinc finger protein 740", "protein_names_refseq": "zinc finger protein 740b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:767693)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18335061;26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005162447.1. COMPLETENESS: full length., [RefSeq]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QPP4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B9H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2B9R7-1", "uniprot_id": "A0A8M2B9R7_DANRE", "mass": 60677.0, "length": 600, "protein_name": "Nucleoporin p58/p45 isoform X1", "gene_name": "nup58", "organism": "Zebrafish", "refseq_name": "nucleoporin p58/p45 isoform X1", "refseq_ac": "XP_073796302", "gene_names_uniprotkb": "nup58; nupl1; wu:fc45d07; wu:fi14f12; wu:fi21d10; zgc:113941; zgc:85711", "gene_names_refseq": "nup58; nupl1; wu:fc45d07; wu:fi14f12; wu:fi21d10; zgc:113941; zgc:85711", "protein_names_uniprotkb": "Nucleoporin p58/p45 isoform X1", "protein_names_refseq": "nucleoporin p58/p45 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:406510)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18507824;26469318;31999691", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IQ05", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005643 nuclear pore", "go_biological_process": "GO:0015031 protein transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2B9R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA15-1", "uniprot_id": "A0A8M2BA15_DANRE", "mass": 25765.0, "length": 218, "protein_name": "DnaJ homolog subfamily B member 9", "gene_name": "dnajb9a", "organism": "Zebrafish", "refseq_name": "dnaJ homolog subfamily B member 9a precursor", "refseq_ac": "NP_001020355", "gene_names_uniprotkb": "dnajb9a; zgc:114162", "gene_names_refseq": "dnajb9a; zgc:114162", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 9; Endoplasmic reticulum DNA J domain-containing protein 4", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 9a; dnaJ homolog subfamily B member 9a precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:574005)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01016921.1, SRR32588727.93673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476742, SAMEA4476799 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On or before Jul 9, 2025 this sequence version replaced XP_005163119.2, NP_001020355.1., [RefSeq]; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QB06", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA25-1", "uniprot_id": "A0A8M2BA25_DANRE", "mass": 74320.0, "length": 645, "protein_name": "GRAM domain-containing protein 4 isoform X1", "gene_name": "gramd4b", "organism": "Zebrafish", "refseq_name": "GRAM domain-containing protein 4 isoform X1", "refseq_ac": "XP_005163098", "gene_names_uniprotkb": "gramd4b", "gene_names_refseq": "gramd4b", "protein_names_uniprotkb": "GRAM domain-containing protein 4 isoform X1", "protein_names_refseq": "GRAM domain-containing protein 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:326055)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006915 apoptotic process;GO:0034164 negative regulation of toll-like receptor 9 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA34-1", "uniprot_id": "A0A8M2BA34_DANRE", "mass": 58155.0, "length": 530, "protein_name": "CCR4-NOT transcription complex subunit 2", "gene_name": "cnot2", "organism": "Zebrafish", "refseq_name": "CCR4-NOT transcription complex subunit 2 isoform X1", "refseq_ac": "XP_005163166", "gene_names_uniprotkb": "cnot2; zgc:162316", "gene_names_refseq": "cnot2; zgc:162316", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2", "protein_names_refseq": "CCR4-NOT transcription complex subunit 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0006355 regulation of DNA-templated transcription;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:2000036 regulation of stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA47-1", "uniprot_id": "A0A8M2BA47_DANRE", "mass": 20417.0, "length": 178, "protein_name": "Troponin I type 2a (Skeletal, fast), tandem duplicate 4 isoform X1", "gene_name": "tnni2a.4", "organism": "Zebrafish", "refseq_name": "troponin I type 2a (skeletal, fast), tandem duplicate 4 isoform X1", "refseq_ac": "XP_005163206", "gene_names_uniprotkb": "tnni2a.4; hm:zehn0173; tnni2; tropI-1d; zgc:86800", "gene_names_refseq": "hm:zehn0173; tnni2a.4; tnni2; tropI-1d; zgc:86800", "protein_names_uniprotkb": "Troponin I type 2a (Skeletal, fast), tandem duplicate 4 isoform X1", "protein_names_refseq": "troponin I type 2a (skeletal, fast), tandem duplicate 4 isoform X1", "tax_id": 7955, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); hypertrophic cardiomyopathy 7 (Disease Ontology:DOID:0110313); dilated cardiomyopathy 1FF (Disease Ontology:DOID:0110459); dilated cardiomyopathy 2A (Disease Ontology:DOID:0110460); familial restrictive cardiomyopathy 1 (Disease Ontology:DOID:0111425); distal arthrogryposis type 2B1 (Disease Ontology:DOID:0111600); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299); coronary artery disease (Disease Ontology:DOID:3393); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0060048 cardiac muscle contraction;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA61-1", "uniprot_id": "A0A8M2BA61_DANRE", "mass": 70106.0, "length": 641, "protein_name": "Proton myo-inositol cotransporter", "gene_name": "slc2a13b", "organism": "Zebrafish", "refseq_name": "solute carrier family 2 member 13b isoform X1", "refseq_ac": "XP_005163236", "gene_names_uniprotkb": "slc2a13b; slc2a13a; slc2a13", "gene_names_refseq": "slc2a13a; slc2a13b; slc2a13", "protein_names_uniprotkb": "Proton myo-inositol cotransporter; H(+)-myo-inositol symporter; Solute carrier family 2 member 13", "protein_names_refseq": "solute carrier family 2 member 13b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0055056 D-glucose transmembrane transporter activity;GO:0005366 myo-inositol:proton symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015798 myo-inositol transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA63-1", "uniprot_id": "A0A8M2BA63_DANRE", "mass": 43655.0, "length": 367, "protein_name": "RNA-binding protein Luc7-like 1 isoform X1", "gene_name": "luc7l", "organism": "Zebrafish", "refseq_name": "putative RNA-binding protein Luc7-like 1 isoform X1", "refseq_ac": "XP_005162955", "gene_names_uniprotkb": "luc7l; wu:fb51e07; wu:fz47d12; zgc:101760; zgc:86815", "gene_names_refseq": "luc7l; wu:fb51e07; wu:fz47d12; zgc:101760; zgc:86815", "protein_names_uniprotkb": "RNA-binding protein Luc7-like 1 isoform X1", "protein_names_refseq": "putative RNA-binding protein Luc7-like 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005162955.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0006376 mRNA splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BA63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BA66-1", "uniprot_id": "A0A8M2BA66_DANRE", "mass": 132780.0, "length": 1168, "protein_name": "Bromodomain-containing protein 1b isoform X1", "gene_name": "brd1b", "organism": "Zebrafish", "refseq_name": "bromodomain-containing protein 1b isoform X1", "refseq_ac": "XP_005163199", "gene_names_uniprotkb": "brd1b; zgc:158610", "gene_names_refseq": "brd1b; zgc:158610", "protein_names_uniprotkb": "Bromodomain-containing protein 1b isoform X1", "protein_names_refseq": "bromodomain-containing protein 1b isoform X1", "tax_id": 7955, "disease": "bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0070776 MOZ/MORF histone acetyltransferase complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BA66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAG4-1", "uniprot_id": "A0A8M2BAG4_DANRE", "mass": 35268.0, "length": 306, "protein_name": "Holocytochrome c-type synthase", "gene_name": "hccsa.1", "organism": "Zebrafish", "refseq_name": "holocytochrome c synthase a isoform X1", "refseq_ac": "XP_005163376", "gene_names_uniprotkb": "hccsa.1; hccsa; zgc:92841", "gene_names_refseq": "hccsa.1; hccsa; zgc:92841", "protein_names_uniprotkb": "Holocytochrome c-type synthase; 4.4.1.17", "protein_names_refseq": "holocytochrome c synthase a isoform X1", "tax_id": 7955, "disease": "linear skin defects with multiple congenital anomalies 1 (Disease Ontology:DOID:0111808); microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (dre:436771)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12234666;16109975;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.4.1.17", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004408 holocytochrome-c synthase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BAG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAG9-1", "uniprot_id": "A0A8M2BAG9_DANRE", "mass": 88201.0, "length": 801, "protein_name": "Cadherin-7a isoform X1", "gene_name": "cdh7a", "organism": "Zebrafish", "refseq_name": "cadherin-7a isoform X1", "refseq_ac": "XP_005163459", "gene_names_uniprotkb": "cdh7a; cdh7", "gene_names_refseq": "cdh7a; cdh7", "protein_names_uniprotkb": "Cadherin-7a isoform X1", "protein_names_refseq": "cadherin-7a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAL5-1", "uniprot_id": "A0A8M2BAL5_DANRE", "mass": 28812.0, "length": 250, "protein_name": "Regulator of G-protein signaling 18 isoform X1", "gene_name": "rgs18", "organism": "Zebrafish", "refseq_name": "regulator of G-protein signaling 18 isoform X1", "refseq_ac": "XP_005163294", "gene_names_uniprotkb": "rgs18; zgc:153888", "gene_names_refseq": "rgs18; zgc:153888", "protein_names_uniprotkb": "Regulator of G-protein signaling 18 isoform X1", "protein_names_refseq": "regulator of G-protein signaling 18 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_005163294.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0071599 otic vesicle development;GO:0048840 otolith development;GO:0009948 anterior/posterior axis specification;GO:0002574 thrombocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAR8-1", "uniprot_id": "A0A8M2BAR8_DANRE", "mass": 47844.0, "length": 402, "protein_name": "Ceramide synthase 2", "gene_name": "cers4b", "organism": "Zebrafish", "refseq_name": "ceramide synthase 2", "refseq_ac": "XP_005163700", "gene_names_uniprotkb": "cers4b", "gene_names_refseq": "cers4b", "protein_names_uniprotkb": "Ceramide synthase 2", "protein_names_refseq": "ceramide synthase 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100330155)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005163700.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAS3-1", "uniprot_id": "A0A8M2BAS3_DANRE", "mass": 31221.0, "length": 277, "protein_name": "protein-serine/threonine phosphatase", "gene_name": "ctdsplb", "organism": "Zebrafish", "refseq_name": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b isoform X1", "refseq_ac": "XP_005163418", "gene_names_uniprotkb": "ctdsplb; wu:fd18d04; zgc:154102", "gene_names_refseq": "ctdsplb; wu:fd18d04; zgc:154102", "protein_names_uniprotkb": "protein-serine/threonine phosphatase; 3.1.3.16", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b isoform X1", "tax_id": 7955, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAW7-1", "uniprot_id": "A0A8M2BAW7_DANRE", "mass": 44914.0, "length": 395, "protein_name": "Atypical chemokine receptor 4", "gene_name": "ackr4a", "organism": "Zebrafish", "refseq_name": "atypical chemokine receptor 4", "refseq_ac": "XP_005163521", "gene_names_uniprotkb": "ackr4a", "gene_names_refseq": "ackr4a", "protein_names_uniprotkb": "Atypical chemokine receptor 4", "protein_names_refseq": "atypical chemokine receptor 4", "tax_id": 7955, "disease": "", "pathway": " (dre:100003167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BAY7-1", "uniprot_id": "A0A8M2BAY7_DANRE", "mass": 17047.0, "length": 161, "protein_name": "Jupiter microtubule associated homolog 1b isoform X1", "gene_name": "jpt1b", "organism": "Zebrafish", "refseq_name": "jupiter microtubule associated homolog 1b isoform X1", "refseq_ac": "XP_005163766", "gene_names_uniprotkb": "jpt1b; HN1; hn1b; wu:fc17g11; zgc:73237", "gene_names_refseq": "HN1; hn1b; jpt1b; wu:fc17g11; zgc:73237", "protein_names_uniprotkb": "Jupiter microtubule associated homolog 1b isoform X1", "protein_names_refseq": "jupiter microtubule associated homolog 1b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005163766.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BAY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BB11-1", "uniprot_id": "A0A8M2BB11_DANRE", "mass": 56824.0, "length": 503, "protein_name": "Cytochrome P450 2K18 isoform X1", "gene_name": "cyp2k18", "organism": "Zebrafish", "refseq_name": "cytochrome P450 2K18 isoform X1", "refseq_ac": "XP_005163790", "gene_names_uniprotkb": "cyp2k18; zgc:66268", "gene_names_refseq": "cyp2k18; zgc:66268", "protein_names_uniprotkb": "Cytochrome P450 2K18 isoform X1", "protein_names_refseq": "cytochrome P450 2K18 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BB11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BB16-1", "uniprot_id": "A0A8M2BB16_DANRE", "mass": 37043.0, "length": 334, "protein_name": "Uncharacterized protein LOC100001340; Uncharacterized protein isoform X1", "gene_name": "si:dkeyp-69e1.8", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC100001340", "refseq_ac": "NP_001120992", "gene_names_uniprotkb": "si:dkeyp-69e1.8", "gene_names_refseq": "si:dkeyp-69e1.8", "protein_names_uniprotkb": "Uncharacterized protein LOC100001340; Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein LOC100001340", "tax_id": 7955, "disease": "", "pathway": " (dre:100001340)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;28252024;40044042", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQQ01011519.1, GFIL01037891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505389, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from JBMGRA010000003.1. On Jul 31, 2008 this sequence version replaced XP_001341357.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0UXS4", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BB16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BB22-1", "uniprot_id": "A0A8M2BB22_DANRE", "mass": 34996.0, "length": 310, "protein_name": "Retinol dehydrogenase 8 isoform X1", "gene_name": "zmp:0000001048", "organism": "Zebrafish", "refseq_name": "retinol dehydrogenase 8 isoform X1", "refseq_ac": "XP_005163825", "gene_names_uniprotkb": "zmp:0000001048", "gene_names_refseq": "zmp:0000001048", "protein_names_uniprotkb": "Retinol dehydrogenase 8 isoform X1", "protein_names_refseq": "retinol dehydrogenase 8 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556557)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005163825.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F0C2", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BB22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BB53-1", "uniprot_id": "A0A8M2BB53_DANRE", "mass": 47591.0, "length": 426, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1", "gene_name": "smarce1", "organism": "Zebrafish", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1", "refseq_ac": "XP_005164046", "gene_names_uniprotkb": "smarce1; baf57; fb33d02; fb54d11; wu:fb33d02; wu:fb54d11", "gene_names_refseq": "baf57; fb33d02; fb54d11; smarce1; wu:fb33d02; wu:fb54d11", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BRG1-associated factor 57", "protein_names_refseq": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1", "tax_id": 7955, "disease": "Coffin-Siris syndrome 5 (Disease Ontology:DOID:0112368); candidiasis (Disease Ontology:DOID:1508); meningioma (Disease Ontology:DOID:3565); familial meningioma (Disease Ontology:DOID:4586)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0016514 SWI/SNF complex;GO:0005634 nucleus", "go_biological_process": "GO:0007399 nervous system development;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0003160 endocardium morphogenesis;GO:0050935 iridophore differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BB53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BB54-1", "uniprot_id": "A0A8M2BB54_DANRE", "mass": 66283.0, "length": 573, "protein_name": "beta-N-acetylhexosaminidase", "gene_name": "si:ch211-173k16.6", "organism": "Zebrafish", "refseq_name": "beta-N-acetylhexosaminidase isoform X1", "refseq_ac": "XP_005163932", "gene_names_uniprotkb": "si:ch211-173k16.6; zgc:113333", "gene_names_refseq": "si:ch211-173k16.6; zgc:113333", "protein_names_uniprotkb": "beta-N-acetylhexosaminidase; 3.2.1.52", "protein_names_refseq": "beta-N-acetylhexosaminidase isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015929 hexosaminidase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BB54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BB99-1", "uniprot_id": "A0A8M2BB99_DANRE", "mass": 46944.0, "length": 420, "protein_name": "Neurotrophin-4", "gene_name": "ntf4", "organism": "Zebrafish", "refseq_name": "uncharacterized protein ntf4", "refseq_ac": "XP_005164029", "gene_names_uniprotkb": "ntf4", "gene_names_refseq": "ntf4", "protein_names_uniprotkb": "Neurotrophin-4", "protein_names_refseq": "uncharacterized protein ntf4", "tax_id": 7955, "disease": "", "pathway": " (dre:100331287)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005164029.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BB99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBA0-1", "uniprot_id": "A0A8M2BBA0_DANRE", "mass": 53808.0, "length": 501, "protein_name": "Monocarboxylate transporter 4-like", "gene_name": "slc16a3a", "organism": "Zebrafish", "refseq_name": "Monocarboxylate transporter 4-like", "refseq_ac": "NP_001119873", "gene_names_uniprotkb": "slc16a3a; MCT4a; MCT4; si:ch211-234h8.7", "gene_names_refseq": "MCT4a; MCT4; si:ch211-234h8.7; slc16a3a", "protein_names_uniprotkb": "Monocarboxylate transporter 4-like", "protein_names_refseq": "Monocarboxylate transporter 4-like; monocarboxylate transporter 4a", "tax_id": 7955, "disease": "", "pathway": " (dre:561627); (R-DRE-210991); (R-DRE-433692)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22496829;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588728.42139889.1, GFIL01036111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000003.1. On Jul 31, 2008 this sequence version replaced XP_690131.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0S7K6", "ec_number_list": "", "go_molecular_function": "GO:0015650 lactate:proton symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BBA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBR8-1", "uniprot_id": "A0A8M2BBR8_DANRE", "mass": 48273.0, "length": 434, "protein_name": "Neuronal pentraxin-2a isoform X1", "gene_name": "nptx2a", "organism": "Zebrafish", "refseq_name": "neuronal pentraxin-2a isoform X1", "refseq_ac": "XP_005164348", "gene_names_uniprotkb": "nptx2a; nptx2", "gene_names_refseq": "nptx2a; nptx2", "protein_names_uniprotkb": "Neuronal pentraxin-2a isoform X1", "protein_names_refseq": "neuronal pentraxin-2a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IRC9;A0AC58IRF0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0051966 regulation of synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBU3-1", "uniprot_id": "A0A8M2BBU3_DANRE", "mass": 110335.0, "length": 1005, "protein_name": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform X1", "gene_name": "elapor2b", "organism": "Zebrafish", "refseq_name": "endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform X1", "refseq_ac": "XP_005164644", "gene_names_uniprotkb": "elapor2b; fc57c04; si:ch73-161g10.2; si:dkey-153k10.9; wu:fc57c04", "gene_names_refseq": "elapor2b; fc57c04; si:ch73-161g10.2; si:dkey-153k10.9; wu:fc57c04", "protein_names_uniprotkb": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform X1", "protein_names_refseq": "endosome/lysosome-associated apoptosis and autophagy regulator family member 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:566596)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20339547;25601102;27189481;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BBU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBY3-1", "uniprot_id": "A0A8M2BBY3_DANRE", "mass": 70631.0, "length": 635, "protein_name": "Solute carrier family 13 member 4 isoform X1", "gene_name": "slc13a4", "organism": "Zebrafish", "refseq_name": "solute carrier family 13 member 4 isoform X1", "refseq_ac": "XP_005164560", "gene_names_uniprotkb": "slc13a4; zgc:162495", "gene_names_refseq": "slc13a4; zgc:162495", "protein_names_uniprotkb": "Solute carrier family 13 member 4 isoform X1", "protein_names_refseq": "solute carrier family 13 member 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015370 solute:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BBZ4-1", "uniprot_id": "A0A8M2BBZ4_DANRE", "mass": 48394.0, "length": 424, "protein_name": "Kelch domain-containing protein 10", "gene_name": "klhdc10", "organism": "Zebrafish", "refseq_name": "kelch domain-containing protein 10 isoform X1", "refseq_ac": "XP_005164752", "gene_names_uniprotkb": "klhdc10; zgc:55663", "gene_names_refseq": "klhdc10; zgc:55663", "protein_names_uniprotkb": "Kelch domain-containing protein 10", "protein_names_refseq": "kelch domain-containing protein 10 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032874 positive regulation of stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BBZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BC07-1", "uniprot_id": "A0A8M2BC07_DANRE", "mass": 46252.0, "length": 419, "protein_name": "Splicing factor 45", "gene_name": "rbm17", "organism": "Zebrafish", "refseq_name": "splicing factor 45 isoform X1", "refseq_ac": "XP_005164871", "gene_names_uniprotkb": "rbm17; zgc:55840", "gene_names_refseq": "rbm17; zgc:55840", "protein_names_uniprotkb": "Splicing factor 45; RNA-binding motif protein 17", "protein_names_refseq": "splicing factor 45 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000380 alternative mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BC07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BC60-1", "uniprot_id": "A0A8M2BC60_DANRE", "mass": 97230.0, "length": 861, "protein_name": "Scm-like with four MBT domains protein 2 isoform X1", "gene_name": "sfmbt2", "organism": "Zebrafish", "refseq_name": "scm-like with four MBT domains protein 2 isoform X1", "refseq_ac": "XP_005164891", "gene_names_uniprotkb": "sfmbt2", "gene_names_refseq": "sfmbt2", "protein_names_uniprotkb": "Scm-like with four MBT domains protein 2 isoform X1", "protein_names_refseq": "scm-like with four MBT domains protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JA20", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BC60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BC68-1", "uniprot_id": "A0A8M2BC68_DANRE", "mass": 56836.0, "length": 504, "protein_name": "Serine/threonine-protein kinase Chk2 isoform X1", "gene_name": "chek2", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase Chk2 isoform X1", "refseq_ac": "XP_073806015", "gene_names_uniprotkb": "chek2; fa66f08; wu:fa66f08; zgc:55865", "gene_names_refseq": "chek2; fa66f08; wu:fa66f08; zgc:55865", "protein_names_uniprotkb": "Serine/threonine-protein kinase Chk2 isoform X1", "protein_names_refseq": "serine/threonine-protein kinase Chk2 isoform X1", "tax_id": 7955, "disease": "female breast cancer (Disease Ontology:DOID:0050671); Li-Fraumeni syndrome 2 (Disease Ontology:DOID:0111504); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); male breast cancer (Disease Ontology:DOID:1614); embryonal carcinoma (Disease Ontology:DOID:3308); osteosarcoma (Disease Ontology:DOID:3347); seminoma (Disease Ontology:DOID:4440); congestive heart failure (Disease Ontology:DOID:6000); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dre:336998)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JHQ5", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BC68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCB3-1", "uniprot_id": "A0A8M2BCB3_DANRE", "mass": 31219.0, "length": 280, "protein_name": "Proteolipid protein 1b isoform X1", "gene_name": "plp1b", "organism": "Zebrafish", "refseq_name": "proteolipid protein 1b isoform X1", "refseq_ac": "XP_005165179", "gene_names_uniprotkb": "plp1b; DMalpha2a; DMalpha2b; DMalpha2c; fv76c02; wu:fv76c02; zgc:91786", "gene_names_refseq": "DMalpha2a; DMalpha2b; DMalpha2c; fv76c02; plp1b; wu:fv76c02; zgc:91786", "protein_names_uniprotkb": "Proteolipid protein 1b isoform X1", "protein_names_refseq": "proteolipid protein 1b isoform X1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 2 (Disease Ontology:DOID:0110773); intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); Pelizaeus-Merzbacher disease (Disease Ontology:DOID:3210)", "pathway": " (dre:368234)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12112375;16289898;16324829;16839543;17425960;35588359;35713703;35754711;36153691;37183607", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0016020 membrane", "go_biological_process": "GO:0022010 central nervous system myelination;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BCB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCB4-1", "uniprot_id": "A0A8M2BCB4_DANRE", "mass": 57814.0, "length": 522, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 11b isoform X1", "gene_name": "slc2a11b", "organism": "Zebrafish", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 11b isoform X1", "refseq_ac": "XP_005165088", "gene_names_uniprotkb": "slc2a11b; fc06b08; si:ch211-207k7.1; si:ch73-266o15.1; wu:fc06b08", "gene_names_refseq": "fc06b08; si:ch211-207k7.1; si:ch73-266o15.1; slc2a11b; wu:fc06b08", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 11b isoform X1", "protein_names_refseq": "solute carrier family 2, facilitated glucose transporter member 11b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0070837 dehydroascorbic acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCC1-1", "uniprot_id": "A0A8M2BCC1_DANRE", "mass": 54632.0, "length": 486, "protein_name": "E3 ubiquitin-protein ligase RNFT2 isoform X1", "gene_name": "rnft2", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNFT2 isoform X1", "refseq_ac": "XP_005165099", "gene_names_uniprotkb": "rnft2; si:dkey-175n1.1; zgc:109947", "gene_names_refseq": "rnft2; si:dkey-175n1.1; zgc:109947", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNFT2 isoform X1", "protein_names_refseq": "E3 ubiquitin-protein ligase RNFT2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:553554)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IZA5;A0AC58JJ37", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCD9-1", "uniprot_id": "A0A8M2BCD9_DANRE", "mass": 73158.0, "length": 647, "protein_name": "Rho GTPase-activating protein 24", "gene_name": "arhgap25", "organism": "Zebrafish", "refseq_name": "rho GTPase-activating protein 25 isoform X1", "refseq_ac": "XP_005165226", "gene_names_uniprotkb": "arhgap25; si:dkey-13n15.4", "gene_names_refseq": "arhgap25; si:dkey-13n15.4", "protein_names_uniprotkb": "Rho GTPase-activating protein 24; Rho-type GTPase-activating protein 24", "protein_names_refseq": "rho GTPase-activating protein 25 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562468)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JJU4", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005856 cytoskeleton;GO:0042995 cell projection;GO:0070161 anchoring junction", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0051058 negative regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BCD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCF3-1", "uniprot_id": "A0A8M2BCF3_DANRE", "mass": 113688.0, "length": 1023, "protein_name": "Protein phosphatase Slingshot homolog 1", "gene_name": "ssh1a", "organism": "Zebrafish", "refseq_name": "protein phosphatase Slingshot homolog 1 isoform X1", "refseq_ac": "XP_005165255", "gene_names_uniprotkb": "ssh1a", "gene_names_refseq": "ssh1a", "protein_names_uniprotkb": "Protein phosphatase Slingshot homolog 1; 3.1.3.16; SSH-like protein 1", "protein_names_refseq": "protein phosphatase Slingshot homolog 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101885659)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0003779 actin binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0032154 cleavage furrow;GO:0030496 midbody", "go_biological_process": "GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCL1-1", "uniprot_id": "A0A8M2BCL1_DANRE", "mass": 37778.0, "length": 344, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1", "gene_name": "gnb2", "organism": "Zebrafish", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1", "refseq_ac": "XP_005165361", "gene_names_uniprotkb": "gnb2; im:7138539; zgc:113357", "gene_names_refseq": "gnb2; im:7138539; zgc:113357", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCL8-1", "uniprot_id": "A0A8M2BCL8_DANRE", "mass": 60831.0, "length": 549, "protein_name": "Synaptic vesicle 2-related protein", "gene_name": "svopa", "organism": "Zebrafish", "refseq_name": "synaptic vesicle 2-related protein", "refseq_ac": "XP_005165254", "gene_names_uniprotkb": "svopa", "gene_names_refseq": "svopa", "protein_names_uniprotkb": "Synaptic vesicle 2-related protein", "protein_names_refseq": "synaptic vesicle 2-related protein", "tax_id": 7955, "disease": "", "pathway": " (dre:559162)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0030672 synaptic vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCP5-1", "uniprot_id": "A0A8M2BCP5_DANRE", "mass": 266982.0, "length": 2389, "protein_name": "Chondroitin sulfate proteoglycan 4 isoform X1", "gene_name": "cspg4ba", "organism": "Zebrafish", "refseq_name": "chondroitin sulfate proteoglycan 4 isoform X1", "refseq_ac": "XP_005165450", "gene_names_uniprotkb": "cspg4ba", "gene_names_refseq": "cspg4ba", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 4 isoform X1", "protein_names_refseq": "chondroitin sulfate proteoglycan 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882096)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005165450.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1RB21", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCU4-1", "uniprot_id": "A0A8M2BCU4_DANRE", "mass": 31167.0, "length": 281, "protein_name": "Protein orai-2 isoform X1", "gene_name": "orai2", "organism": "Zebrafish", "refseq_name": "protein orai-2 isoform X1", "refseq_ac": "XP_005165627", "gene_names_uniprotkb": "orai2; si:dkey-261j4.7", "gene_names_refseq": "orai2; si:dkey-261j4.7", "protein_names_uniprotkb": "Protein orai-2 isoform X1", "protein_names_refseq": "protein orai-2 isoform X1", "tax_id": 7955, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dre:555612)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "26469318;27189481;29690872;29931586;30889933;32455839;32867296", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2BCU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCW6-1", "uniprot_id": "A0A8M2BCW6_DANRE", "mass": 108933.0, "length": 948, "protein_name": "Phospholipase", "gene_name": "pld2", "organism": "Zebrafish", "refseq_name": "phospholipase D2 isoform X1", "refseq_ac": "XP_068077564", "gene_names_uniprotkb": "pld2", "gene_names_refseq": "pld2", "protein_names_uniprotkb": "Phospholipase; 3.1.4.4", "protein_names_refseq": "phospholipase D2 isoform X1", "tax_id": 7955, "disease": "developmental cardiac valvular defect (Disease Ontology:DOID:0080633); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:565743)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.4;3.1.4.39", "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0009395 phospholipid catabolic process;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BCW7-1", "uniprot_id": "A0A8M2BCW7_DANRE", "mass": 44228.0, "length": 401, "protein_name": "E3 ubiquitin-protein ligase RNF167", "gene_name": "rnf167", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF167", "refseq_ac": "XP_005165694", "gene_names_uniprotkb": "rnf167", "gene_names_refseq": "rnf167", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF167; 2.3.2.27; RING finger protein 167", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF167", "tax_id": 7955, "disease": "", "pathway": " (dre:101055497)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005165694.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1QQE8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BCW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BD12-1", "uniprot_id": "A0A8M2BD12_DANRE", "mass": 39654.0, "length": 358, "protein_name": "Tomoregulin-2", "gene_name": "tmeff2b", "organism": "Zebrafish", "refseq_name": "tomoregulin-2", "refseq_ac": "XP_021332671", "gene_names_uniprotkb": "tmeff2b", "gene_names_refseq": "tmeff2b", "protein_names_uniprotkb": "Tomoregulin-2", "protein_names_refseq": "tomoregulin-2", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054)", "pathway": " (dre:797681)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1Q8Z6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BD12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BD47-1", "uniprot_id": "A0A8M2BD47_DANRE", "mass": 86688.0, "length": 785, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 23 isoform X2", "gene_name": "adam23a", "organism": "Zebrafish", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 23 isoform X2", "refseq_ac": "XP_005165908", "gene_names_uniprotkb": "adam23a", "gene_names_refseq": "adam23a", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 23 isoform X2", "protein_names_refseq": "disintegrin and metalloproteinase domain-containing protein 23 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:794175); (R-DRE-5682910)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0012505 endomembrane system;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BD47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BD60-1", "uniprot_id": "A0A8M2BD60_DANRE", "mass": 103982.0, "length": 945, "protein_name": "Receptor-type tyrosine-protein phosphatase-like N isoform X1", "gene_name": "ptprnb", "organism": "Zebrafish", "refseq_name": "receptor-type tyrosine-protein phosphatase-like N isoform X1", "refseq_ac": "XP_005165924", "gene_names_uniprotkb": "ptprnb", "gene_names_refseq": "ptprnb", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase-like N isoform X1", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase-like N isoform X1", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:564351)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0030141 secretory granule;GO:0045202 synapse;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0051046 regulation of secretion;GO:0035773 insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BD60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDC5-1", "uniprot_id": "A0A8M2BDC5_DANRE", "mass": 23539.0, "length": 208, "protein_name": "Ras-related protein Rab-6B", "gene_name": "rab6ba", "organism": "Zebrafish", "refseq_name": "RAB6B, member RAS oncogene family a isoform X1", "refseq_ac": "XP_005165989", "gene_names_uniprotkb": "rab6ba; rab6b; zgc:110405", "gene_names_refseq": "rab6ba; rab6b; zgc:110405", "protein_names_uniprotkb": "Ras-related protein Rab-6B; 3.6.5.2", "protein_names_refseq": "RAB6B, member RAS oncogene family a isoform X1", "tax_id": 7955, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 8, 2024 this sequence version replaced XP_005165989.1. COMPLETENESS: full length., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Recruits VPS13B to the Golgi membrane. Regulates the compacted morphology of the Golgi. Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells. Plays a role in neuron projection development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.5;3.6.1.5;3.6.5.-;3.6.1.-;3.6.5.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031410 cytoplasmic vesicle;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDE3-1", "uniprot_id": "A0A8M2BDE3_DANRE", "mass": 128726.0, "length": 1179, "protein_name": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "gene_name": "kank4", "organism": "Zebrafish", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "refseq_ac": "XP_068078101", "gene_names_uniprotkb": "kank4", "gene_names_refseq": "kank4", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dre:101884737)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JVD6;E7F3U4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDG6-1", "uniprot_id": "A0A8M2BDG6_DANRE", "mass": 141392.0, "length": 1272, "protein_name": "Vigilin", "gene_name": "hdlbpa", "organism": "Zebrafish", "refseq_name": "high density lipoprotein binding protein a", "refseq_ac": "NP_958882", "gene_names_uniprotkb": "hdlbpa; HBP; cb591; cb811; hdlbp; wu:fb36d01; wu:fb94h08; wu:fc23d06; wu:fc75h07", "gene_names_refseq": "HBP; cb591; cb811; hdlbpa; hdlbp; wu:fb36d01; wu:fb94h08; wu:fc23d06; wu:fc75h07", "protein_names_uniprotkb": "Vigilin; High density lipoprotein-binding protein", "protein_names_refseq": "high density lipoprotein binding protein a; high density lipoprotein-binding protein (vigilin)", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (R-DRE-8964011)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12941645", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC051153.1, SRR32588727.341495.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000006.1. On Jul 16, 2025 this sequence version replaced NP_958882.1., [RefSeq]; Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol., [UniProtKB, UniProtKB]; High expression in the liver and ovary suggests a role for this molecule in the cumulative efficiency of fish intake of food or lipid transfer, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1R9Y8", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BDG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDH6-1", "uniprot_id": "A0A8M2BDH6_DANRE", "mass": 59561.0, "length": 532, "protein_name": "Beta-1,4 N-acetylgalactosaminyltransferase", "gene_name": "b4galnt1b", "organism": "Zebrafish", "refseq_name": "beta-1,4 N-acetylgalactosaminyltransferase 1", "refseq_ac": "XP_005166146", "gene_names_uniprotkb": "b4galnt1b", "gene_names_refseq": "b4galnt1b", "protein_names_uniprotkb": "Beta-1,4 N-acetylgalactosaminyltransferase", "protein_names_refseq": "beta-1,4 N-acetylgalactosaminyltransferase 1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 26 (Disease Ontology:DOID:0110777)", "pathway": " (dre:793635); (R-DRE-9840309)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "X1WFC5", "ec_number_list": "", "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDH8-1", "uniprot_id": "A0A8M2BDH8_DANRE", "mass": 88322.0, "length": 765, "protein_name": "Cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform X1", "gene_name": "cnga3a", "organism": "Zebrafish", "refseq_name": "cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform X1", "refseq_ac": "XP_005166141", "gene_names_uniprotkb": "cnga3a", "gene_names_refseq": "cnga3a", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform X1", "protein_names_refseq": "cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform X1", "tax_id": 7955, "disease": "achromatopsia 2 (Disease Ontology:DOID:0110007); color blindness (Disease Ontology:DOID:13399)", "pathway": " (dre:567242)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030553 cGMP binding;GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0016020 membrane", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDI4-1", "uniprot_id": "A0A8M2BDI4_DANRE", "mass": 45280.0, "length": 402, "protein_name": "TEA domain family member 3 b isoform X7", "gene_name": "tead3b", "organism": "Zebrafish", "refseq_name": "TEA domain family member 3 b isoform X7", "refseq_ac": "XP_005166203", "gene_names_uniprotkb": "tead3b; zgc:171784", "gene_names_refseq": "tead3b; zgc:171784", "protein_names_uniprotkb": "TEA domain family member 3 b isoform X7", "protein_names_refseq": "TEA domain family member 3 b isoform X7", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035329 hippo signaling;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDJ3-1", "uniprot_id": "A0A8M2BDJ3_DANRE", "mass": 30421.0, "length": 267, "protein_name": "Adenosine receptor A3", "gene_name": "adora3a.1", "organism": "Zebrafish", "refseq_name": "adenosine receptor A3", "refseq_ac": "XP_005166208", "gene_names_uniprotkb": "adora3a.1", "gene_names_refseq": "adora3a.1", "protein_names_uniprotkb": "Adenosine receptor A3", "protein_names_refseq": "adenosine receptor A3", "tax_id": 7955, "disease": "", "pathway": " (dre:562364)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005166208.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JWI4;A0AC58JWJ4", "ec_number_list": "", "go_molecular_function": "GO:0001609 G protein-coupled adenosine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDL6-1", "uniprot_id": "A0A8M2BDL6_DANRE", "mass": 27508.0, "length": 247, "protein_name": "E3 ubiquitin-protein ligase RNF182", "gene_name": "LOC797048", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF182", "refseq_ac": "XP_005166214", "gene_names_uniprotkb": "LOC797048", "gene_names_refseq": "LOC797048", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF182; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF182", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JWJ7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDP3-1", "uniprot_id": "A0A8M2BDP3_DANRE", "mass": 99835.0, "length": 894, "protein_name": "Metabotropic glutamate receptor 2", "gene_name": "grm2a", "organism": "Zebrafish", "refseq_name": "metabotropic glutamate receptor 2 isoform X1", "refseq_ac": "XP_005166174", "gene_names_uniprotkb": "grm2a; wu:fj52c07", "gene_names_refseq": "grm2a; wu:fj52c07", "protein_names_uniprotkb": "Metabotropic glutamate receptor 2", "protein_names_refseq": "metabotropic glutamate receptor 2 isoform X1", "tax_id": 7955, "disease": "schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-DRE-418594); (R-DRE-420499)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FDL9", "ec_number_list": "", "go_molecular_function": "GO:0001641 group II metabotropic glutamate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0051966 regulation of synaptic transmission, glutamatergic;GO:0007216 G protein-coupled glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDP4-1", "uniprot_id": "A0A8M2BDP4_DANRE", "mass": 89661.0, "length": 777, "protein_name": "DnaJ homolog subfamily C member 16", "gene_name": "dnajc16", "organism": "Zebrafish", "refseq_name": "dnaJ homolog subfamily C member 16 isoform X1", "refseq_ac": "XP_005166271", "gene_names_uniprotkb": "dnajc16", "gene_names_refseq": "dnajc16", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 16; Endoplasmic reticulum DNA J domain-containing protein 8", "protein_names_refseq": "dnaJ homolog subfamily C member 16 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559762)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005166271.1. COMPLETENESS: full length., [RefSeq]; Plays an important role in regulating the size of autophagosomes during the formation process., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDU6-1", "uniprot_id": "A0A8M2BDU6_DANRE", "mass": 124303.0, "length": 1087, "protein_name": "Phosphorylase b kinase regulatory subunit", "gene_name": "phkb", "organism": "Zebrafish", "refseq_name": "phosphorylase b kinase regulatory subunit beta isoform X2", "refseq_ac": "XP_005166460", "gene_names_uniprotkb": "phkb", "gene_names_refseq": "phkb", "protein_names_uniprotkb": "Phosphorylase b kinase regulatory subunit", "protein_names_refseq": "phosphorylase b kinase regulatory subunit beta isoform X2", "tax_id": 7955, "disease": "glycogen storage disease IXb (Disease Ontology:DOID:0111041)", "pathway": " (dre:569706); (R-DRE-70221)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005964 phosphorylase kinase complex", "go_biological_process": "GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDX8-1", "uniprot_id": "A0A8M2BDX8_DANRE", "mass": 72611.0, "length": 667, "protein_name": "CREB-regulated transcription coactivator 3 isoform X1", "gene_name": "crtc3", "organism": "Zebrafish", "refseq_name": "CREB-regulated transcription coactivator 3 isoform X1", "refseq_ac": "XP_005166549", "gene_names_uniprotkb": "crtc3", "gene_names_refseq": "crtc3", "protein_names_uniprotkb": "CREB-regulated transcription coactivator 3 isoform X1", "protein_names_refseq": "CREB-regulated transcription coactivator 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570024)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G0Z9", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization;GO:0071320 cellular response to cAMP;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BDX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BDY0-1", "uniprot_id": "A0A8M2BDY0_DANRE", "mass": 153136.0, "length": 1377, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "parp142.2", "organism": "Zebrafish", "refseq_name": "protein mono-ADP-ribosyltransferase PARP14", "refseq_ac": "XP_005166412", "gene_names_uniprotkb": "parp142.2", "gene_names_refseq": "parp142.2", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "protein mono-ADP-ribosyltransferase PARP14", "tax_id": 7955, "disease": "", "pathway": " (dre:101885359)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BDY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE08-1", "uniprot_id": "A0A8M2BE08_DANRE", "mass": 88004.0, "length": 797, "protein_name": "Semaphorin-4F isoform X1", "gene_name": "sema4f", "organism": "Zebrafish", "refseq_name": "semaphorin-4F isoform X1", "refseq_ac": "XP_005166611", "gene_names_uniprotkb": "sema4f", "gene_names_refseq": "sema4f", "protein_names_uniprotkb": "Semaphorin-4F isoform X1", "protein_names_refseq": "semaphorin-4F isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556003)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BE08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE56-1", "uniprot_id": "A0A8M2BE56_DANRE", "mass": 39914.0, "length": 348, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "ark2cb", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase ARK2C isoform X1", "refseq_ac": "XP_005166736", "gene_names_uniprotkb": "ark2cb", "gene_names_refseq": "ark2cb", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase ARK2C isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:572413)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BE56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BE79-1", "uniprot_id": "A0A8M2BE79_DANRE", "mass": 64048.0, "length": 563, "protein_name": "PHD finger protein 19 isoform X1", "gene_name": "phf19", "organism": "Zebrafish", "refseq_name": "PHD finger protein 19 isoform X1", "refseq_ac": "XP_005166909", "gene_names_uniprotkb": "phf19; phf13; si:dkeyp-51b7.1", "gene_names_refseq": "phf13; phf19; si:dkeyp-51b7.1", "protein_names_uniprotkb": "PHD finger protein 19 isoform X1", "protein_names_refseq": "PHD finger protein 19 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:560078)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24240475;25556858;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045814 negative regulation of gene expression, epigenetic;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BE79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEA1-1", "uniprot_id": "A0A8M2BEA1_DANRE", "mass": 32853.0, "length": 308, "protein_name": "Non-selective voltage-gated ion channel VDAC3", "gene_name": "vdac3", "organism": "Zebrafish", "refseq_name": "voltage-dependent anion-selective channel protein 3 isoform X1", "refseq_ac": "XP_005166803", "gene_names_uniprotkb": "vdac3; wu:fb01e12; zgc:77898", "gene_names_refseq": "vdac3; wu:fb01e12; zgc:77898", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC3", "protein_names_refseq": "voltage-dependent anion-selective channel protein 3 isoform X1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dre:406529)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations. Involved in male fertility and sperm mitochondrial sheath formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;5.6.1.6;7.6.2.3;2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0015288 porin activity;GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0046930 pore complex", "go_biological_process": "GO:0031101 fin regeneration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BED2-1", "uniprot_id": "A0A8M2BED2_DANRE", "mass": 121728.0, "length": 1085, "protein_name": "CRK SH3-binding GNRP", "gene_name": "rapgef1a", "organism": "Zebrafish", "refseq_name": "rap guanine nucleotide exchange factor 1 isoform X1", "refseq_ac": "XP_005166961", "gene_names_uniprotkb": "rapgef1a", "gene_names_refseq": "rapgef1a", "protein_names_uniprotkb": "CRK SH3-binding GNRP", "protein_names_refseq": "rap guanine nucleotide exchange factor 1 isoform X1", "tax_id": 7955, "disease": "anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783)", "pathway": " (dre:558635)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0001570 vasculogenesis;GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BED2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BED9-1", "uniprot_id": "A0A8M2BED9_DANRE", "mass": 45034.0, "length": 402, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "mkrn4", "organism": "Zebrafish", "refseq_name": "makorin, ring finger protein, 4 isoform X1", "refseq_ac": "XP_005167100", "gene_names_uniprotkb": "mkrn4; fi27c05; si:ch73-237c6.4; wu:fi27c05", "gene_names_refseq": "fi27c05; mkrn4; si:ch73-237c6.4; wu:fi27c05", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "makorin, ring finger protein, 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559882)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21172006;26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BED9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEF5-1", "uniprot_id": "A0A8M2BEF5_DANRE", "mass": 42142.0, "length": 384, "protein_name": "Adherens junction-associated protein 1", "gene_name": "ajap1", "organism": "Zebrafish", "refseq_name": "adherens junction-associated protein 1", "refseq_ac": "XP_005167007", "gene_names_uniprotkb": "ajap1", "gene_names_refseq": "ajap1", "protein_names_uniprotkb": "Adherens junction-associated protein 1", "protein_names_refseq": "adherens junction-associated protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:101887016)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IPJ8", "ec_number_list": "", "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0009898 cytoplasmic side of plasma membrane;GO:0044291 cell-cell contact zone", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEI0-1", "uniprot_id": "A0A8M2BEI0_DANRE", "mass": 21312.0, "length": 204, "protein_name": "Podoplanin isoform X1", "gene_name": "pdpn", "organism": "Zebrafish", "refseq_name": "podoplanin isoform X1", "refseq_ac": "XP_005167102", "gene_names_uniprotkb": "pdpn; fc72g03; im:7049455; si:ch211-156j16.1; wu:fc72g03", "gene_names_refseq": "fc72g03; im:7049455; si:ch211-156j16.1; wu:fc72g03", "protein_names_uniprotkb": "Podoplanin isoform X1", "protein_names_refseq": "podoplanin isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564557)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0016477 cell migration;GO:1901731 positive regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BEI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEJ0-1", "uniprot_id": "A0A8M2BEJ0_DANRE", "mass": 51736.0, "length": 461, "protein_name": "G-protein coupled receptor 61", "gene_name": "gpr61", "organism": "Zebrafish", "refseq_name": "G-protein coupled receptor 61", "refseq_ac": "XP_005167170", "gene_names_uniprotkb": "gpr61", "gene_names_refseq": "gpr61", "protein_names_uniprotkb": "G-protein coupled receptor 61", "protein_names_refseq": "G-protein coupled receptor 61", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58G9V5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0038035 ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEJ3-1", "uniprot_id": "A0A8M2BEJ3_DANRE", "mass": 54424.0, "length": 491, "protein_name": "Sodium-coupled neutral amino acid transporter 3", "gene_name": "slc38a5a", "organism": "Zebrafish", "refseq_name": "sodium-coupled neutral amino acid transporter 3", "refseq_ac": "XP_001344749", "gene_names_uniprotkb": "slc38a5a", "gene_names_refseq": "slc38a5a", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 3", "protein_names_refseq": "sodium-coupled neutral amino acid transporter 3", "tax_id": 7955, "disease": "", "pathway": " (dre:100005797)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0032329 serine transport;GO:0006868 glutamine transport;GO:0089709 L-histidine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEK7-1", "uniprot_id": "A0A8M2BEK7_DANRE", "mass": 51943.0, "length": 468, "protein_name": "cAMP responsive element binding protein 3-like 3 like", "gene_name": "creb3l3l", "organism": "Zebrafish", "refseq_name": "cAMP responsive element binding protein 3-like 3 like", "refseq_ac": "NP_998697", "gene_names_uniprotkb": "creb3l3l; creb3l3; wu:fj05f07; zgc:66452", "gene_names_refseq": "creb3l3l; creb3l3; wu:fj05f07; zgc:66452", "protein_names_uniprotkb": "cAMP responsive element binding protein 3-like 3 like", "protein_names_refseq": "cAMP responsive element binding protein 3-like 3 like", "tax_id": 7955, "disease": "", "pathway": " (dre:406853)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16109975;17013923;17949705;21854210;24637248;26183212", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC055664.1, GFIL01007259.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000008.1. On Oct 1, 2011 this sequence version replaced NP_998697.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Transcriptional activator. Binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with atf6. Regulates FGF21 transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BEK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEM8-1", "uniprot_id": "A0A8M2BEM8_DANRE", "mass": 70626.0, "length": 619, "protein_name": "nucleoside-triphosphate phosphatase", "gene_name": "entpd4", "organism": "Zebrafish", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 4 isoform X1", "refseq_ac": "XP_005167275", "gene_names_uniprotkb": "entpd4; wu:fd44h12; wu:fi73e02; zgc:92668", "gene_names_refseq": "entpd4; wu:fd44h12; wu:fi73e02; zgc:92668", "protein_names_uniprotkb": "nucleoside-triphosphate phosphatase; 3.6.1.15", "protein_names_refseq": "ectonucleoside triphosphate diphosphohydrolase 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006256 UDP catabolic process;GO:0046036 CTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEQ0-1", "uniprot_id": "A0A8M2BEQ0_DANRE", "mass": 54459.0, "length": 487, "protein_name": "Nuclear receptor subfamily 1, group H, member 5 isoform X1", "gene_name": "nr1h5", "organism": "Zebrafish", "refseq_name": "nuclear receptor subfamily 1, group H, member 5 isoform X1", "refseq_ac": "XP_005166790", "gene_names_uniprotkb": "nr1h5; fxrbeta; gb:dq017614", "gene_names_refseq": "fxrbeta; gb:dq017614; nr1h5", "protein_names_uniprotkb": "Nuclear receptor subfamily 1, group H, member 5 isoform X1", "protein_names_refseq": "nuclear receptor subfamily 1, group H, member 5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:557500)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17997606;25711679;26024593;26469318;29592890;31791229;34301599", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2BEQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BET4-1", "uniprot_id": "A0A8M2BET4_DANRE", "mass": 66390.0, "length": 590, "protein_name": "UDP glucuronosyltransferase 5 family, polypeptide E1 isoform X1", "gene_name": "ugt5e1", "organism": "Zebrafish", "refseq_name": "UDP glucuronosyltransferase 5 family, polypeptide E1 isoform X1", "refseq_ac": "XP_005166829", "gene_names_uniprotkb": "ugt5e1; si:ch211-229n2.5", "gene_names_refseq": "si:ch211-229n2.5; ugt5e1", "protein_names_uniprotkb": "UDP glucuronosyltransferase 5 family, polypeptide E1 isoform X1", "protein_names_refseq": "UDP glucuronosyltransferase 5 family, polypeptide E1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BET4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BET8-1", "uniprot_id": "A0A8M2BET8_DANRE", "mass": 46331.0, "length": 409, "protein_name": "Cell division cycle-associated protein 7a isoform X1", "gene_name": "cdca7a", "organism": "Zebrafish", "refseq_name": "cell division cycle-associated protein 7a isoform X1", "refseq_ac": "XP_005167472", "gene_names_uniprotkb": "cdca7a; cdca7; sb:cb590; sr:nyz142; zgc:110113", "gene_names_refseq": "cdca7a; cdca7; sb:cb590; sr:nyz142; zgc:110113", "protein_names_uniprotkb": "Cell division cycle-associated protein 7a isoform X1", "protein_names_refseq": "cell division cycle-associated protein 7a isoform X1", "tax_id": 7955, "disease": "immunodeficiency-centromeric instability-facial anomalies syndrome 3 (Disease Ontology:DOID:0090010)", "pathway": " (dre:550236)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23213226;24198278;25385755;26469318;30484769", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription;GO:0048538 thymus development;GO:1902036 regulation of hematopoietic stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BET8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEU9-1", "uniprot_id": "A0A8M2BEU9_DANRE", "mass": 19774.0, "length": 176, "protein_name": "Secreted phosphoprotein 24", "gene_name": "LOC101885154", "organism": "Zebrafish", "refseq_name": "secreted phosphoprotein 24", "refseq_ac": "XP_005167566", "gene_names_uniprotkb": "LOC101885154", "gene_names_refseq": "LOC101885154", "protein_names_uniprotkb": "Secreted phosphoprotein 24; Secreted phosphoprotein 2", "protein_names_refseq": "secreted phosphoprotein 24", "tax_id": 7955, "disease": "", "pathway": " (dre:101885154)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Could coordinate an aspect of bone turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0046849 bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEV0-1", "uniprot_id": "A0A8M2BEV0_DANRE", "mass": 41300.0, "length": 372, "protein_name": "Hexosyltransferase", "gene_name": "b3galt4", "organism": "Zebrafish", "refseq_name": "beta-1,3-galactosyltransferase 9", "refseq_ac": "XP_005167417", "gene_names_uniprotkb": "b3galt4", "gene_names_refseq": "b3galt4", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "beta-1,3-galactosyltransferase 9", "tax_id": 7955, "disease": "", "pathway": " (dre:101886595)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BEV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BEZ5-1", "uniprot_id": "A0A8M2BEZ5_DANRE", "mass": 130944.0, "length": 1204, "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "wdr6", "organism": "Zebrafish", "refseq_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6 isoform X1", "refseq_ac": "XP_005167036", "gene_names_uniprotkb": "wdr6; si:dkey-20d21.7", "gene_names_refseq": "si:dkey-20d21.7; wdr6", "protein_names_uniprotkb": "tRNA (34-2'-O)-methyltransferase regulator WDR6; WD repeat-containing protein 6", "protein_names_refseq": "tRNA (34-2'-O)-methyltransferase regulator WDR6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100004270)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21852962;25479044;26469318;27189481;27307198", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BEZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BF06-1", "uniprot_id": "A0A8M2BF06_DANRE", "mass": 73194.0, "length": 648, "protein_name": "ATP-binding cassette sub-family B member 6", "gene_name": "abcb6b", "organism": "Zebrafish", "refseq_name": "ATP-binding cassette sub-family B member 6 isoform X1", "refseq_ac": "XP_005167575", "gene_names_uniprotkb": "abcb6b", "gene_names_refseq": "abcb6b", "protein_names_uniprotkb": "ATP-binding cassette sub-family B member 6; 7.6.2.5; ABC-type heme transporter ABCB6", "protein_names_refseq": "ATP-binding cassette sub-family B member 6 isoform X1", "tax_id": 7955, "disease": "dyschromatosis universalis hereditaria (Disease Ontology:DOID:0060304)", "pathway": " (dre:100004801)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.5", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015439 ABC-type heme transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BF06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BF48-1", "uniprot_id": "A0A8M2BF48_DANRE", "mass": 34542.0, "length": 324, "protein_name": "Cyclic AMP-responsive element-binding protein 1b isoform X1", "gene_name": "creb1b", "organism": "Zebrafish", "refseq_name": "cyclic AMP-responsive element-binding protein 1b isoform 1", "refseq_ac": "NP_001428340", "gene_names_uniprotkb": "creb1b; zgc:110211", "gene_names_refseq": "creb1b; zgc:110211", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 1b isoform X1", "protein_names_refseq": "cyclic AMP-responsive element-binding protein 1b isoform 1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); obsessive-compulsive disorder (Disease Ontology:DOID:10933); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); morphine dependence (Disease Ontology:DOID:2560); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); vascular dementia (Disease Ontology:DOID:8725); substance dependence (Disease Ontology:DOID:9973); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-DRE-198693); (R-DRE-199920); (R-DRE-375165); (R-DRE-442742); (R-DRE-881907); (R-DRE-9031628); (R-DRE-9634638)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01007250.1, SRR32588733.899680.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jun 10, 2025 this sequence version replaced XP_005167757.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IFU8", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0035497 cAMP response element binding", "go_cellular_component": "GO:1990589 ATF4-CREB1 transcription factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0141156 cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BF48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BF56-1", "uniprot_id": "A0A8M2BF56_DANRE", "mass": 200838.0, "length": 1743, "protein_name": "Sodium leak channel NALCN", "gene_name": "nalcn", "organism": "Zebrafish", "refseq_name": "sodium leak channel NALCN isoform X1", "refseq_ac": "XP_005167755", "gene_names_uniprotkb": "nalcn; zgc:113349", "gene_names_refseq": "nalcn; zgc:113349", "protein_names_uniprotkb": "Sodium leak channel NALCN; Sodium leak channel non-selective protein; Voltage gated channel-like protein 1", "protein_names_refseq": "sodium leak channel NALCN isoform X1", "tax_id": 7955, "disease": "congenital limbs-face contractures-hypotonia-developmental delay syndrome (Disease Ontology:DOID:0081048)", "pathway": " (dre:548345)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;27189481;28252024;32959503", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0032230 positive regulation of synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BF56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BF71-1", "uniprot_id": "A0A8M2BF71_DANRE", "mass": 231918.0, "length": 2051, "protein_name": "ribonuclease H", "gene_name": "LOC101886700", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_005167247", "gene_names_uniprotkb": "LOC101886700", "gene_names_refseq": "LOC101886700", "protein_names_uniprotkb": "ribonuclease H; 3.1.26.4", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:101886700)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "", "go_biological_process": "GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BF71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BF89-1", "uniprot_id": "A0A8M2BF89_DANRE", "mass": 77258.0, "length": 708, "protein_name": "Solute carrier family 12 member 8", "gene_name": "slc12a8", "organism": "Zebrafish", "refseq_name": "solute carrier family 12 member 8 isoform X1", "refseq_ac": "XP_005167859", "gene_names_uniprotkb": "slc12a8; fi11e03; si:dkey-101k6.7; wu:fi11e03", "gene_names_refseq": "fi11e03; si:dkey-101k6.7; slc12a8; wu:fi11e03", "protein_names_uniprotkb": "Solute carrier family 12 member 8", "protein_names_refseq": "solute carrier family 12 member 8 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100000006)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;26595314;27189481;27903883", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015379 potassium:chloride symporter activity;GO:0015377 chloride:monoatomic cation symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0060271 cilium assembly;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BF89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFD9-1", "uniprot_id": "A0A8M2BFD9_DANRE", "mass": 67275.0, "length": 581, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "galnt13", "organism": "Zebrafish", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 13 isoform X1", "refseq_ac": "XP_005168002", "gene_names_uniprotkb": "galnt13", "gene_names_refseq": "galnt13", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "polypeptide N-acetylgalactosaminyltransferase 13 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168002.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFF0-1", "uniprot_id": "A0A8M2BFF0_DANRE", "mass": 52188.0, "length": 474, "protein_name": "Cytokine receptor family member b2 isoform X1", "gene_name": "crfb2", "organism": "Zebrafish", "refseq_name": "cytokine receptor family member b2 isoform X1", "refseq_ac": "XP_005168017", "gene_names_uniprotkb": "crfb2", "gene_names_refseq": "crfb2", "protein_names_uniprotkb": "Cytokine receptor family member b2 isoform X1", "protein_names_refseq": "cytokine receptor family member b2 isoform X1", "tax_id": 7955, "disease": "immunodeficiency 45 (Disease Ontology:DOID:0111994); hepatitis B (Disease Ontology:DOID:2043)", "pathway": " (dre:777653)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17371995;18039395;19300512;19717522;21048110;35360100;36405758;37146740;38244820;39558430", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004904 interferon receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BFF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFL1-1", "uniprot_id": "A0A8M2BFL1_DANRE", "mass": 58932.0, "length": 535, "protein_name": "Retinoblastoma-binding protein 5", "gene_name": "rbbp5", "organism": "Zebrafish", "refseq_name": "retinoblastoma-binding protein 5 isoform X1", "refseq_ac": "XP_005168325", "gene_names_uniprotkb": "rbbp5; zgc:56078; zgc:85864", "gene_names_refseq": "rbbp5; zgc:56078; zgc:85864", "protein_names_uniprotkb": "Retinoblastoma-binding protein 5", "protein_names_refseq": "retinoblastoma-binding protein 5 isoform X1", "tax_id": 7955, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0048188 Set1C/COMPASS complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFL7-1", "uniprot_id": "A0A8M2BFL7_DANRE", "mass": 202516.0, "length": 1778, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha", "gene_name": "cacna1sa", "organism": "Zebrafish", "refseq_name": "calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1", "refseq_ac": "XP_005168332", "gene_names_uniprotkb": "cacna1sa", "gene_names_refseq": "cacna1sa", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha", "protein_names_refseq": "calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1", "tax_id": 7955, "disease": "Timothy syndrome (Disease Ontology:DOID:0060173); congenital myopathy 18 (Disease Ontology:DOID:0081350); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0042383 sarcolemma;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFN3-1", "uniprot_id": "A0A8M2BFN3_DANRE", "mass": 73260.0, "length": 645, "protein_name": "Myotubularin-related protein 7b isoform X1", "gene_name": "mtmr7b", "organism": "Zebrafish", "refseq_name": "myotubularin-related protein 7b isoform X1", "refseq_ac": "XP_005168409", "gene_names_uniprotkb": "mtmr7b; zgc:114101", "gene_names_refseq": "mtmr7b; zgc:114101", "protein_names_uniprotkb": "Myotubularin-related protein 7b isoform X1", "protein_names_refseq": "myotubularin-related protein 7b isoform X1", "tax_id": 7955, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168409.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFQ0-1", "uniprot_id": "A0A8M2BFQ0_DANRE", "mass": 95970.0, "length": 864, "protein_name": "DENN domain-containing protein 1B isoform X1", "gene_name": "dennd1c", "organism": "Zebrafish", "refseq_name": "DENN domain-containing protein 1B isoform X1", "refseq_ac": "XP_005168459", "gene_names_uniprotkb": "dennd1c", "gene_names_refseq": "dennd1c", "protein_names_uniprotkb": "DENN domain-containing protein 1B isoform X1", "protein_names_refseq": "DENN domain-containing protein 1B isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101886409)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFQ9-1", "uniprot_id": "A0A8M2BFQ9_DANRE", "mass": 61614.0, "length": 534, "protein_name": "Deoxyribodipyrimidine photo-lyase", "gene_name": "cpdp", "organism": "Zebrafish", "refseq_name": "CPD photolyase isoform X1", "refseq_ac": "XP_005168471", "gene_names_uniprotkb": "cpdp; phr; zgc:66475", "gene_names_refseq": "cpdp; phr; zgc:66475", "protein_names_uniprotkb": "Deoxyribodipyrimidine photo-lyase; 4.1.99.3; DNA photolyase; Photoreactivating enzyme", "protein_names_refseq": "CPD photolyase isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:394039)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003904 deoxyribodipyrimidine photo-lyase activity", "go_cellular_component": "", "go_biological_process": "GO:0009650 UV protection;GO:0000719 photoreactive repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFR1-1", "uniprot_id": "A0A8M2BFR1_DANRE", "mass": 41149.0, "length": 355, "protein_name": "Chemokine (C-C motif) receptor 12a", "gene_name": "ccr12a", "organism": "Zebrafish", "refseq_name": "chemokine (C-C motif) receptor 12a", "refseq_ac": "NP_001038492", "gene_names_uniprotkb": "ccr12a; ccr12.3; si:ch211-106n13.2", "gene_names_refseq": "ccr12.3; ccr12a; si:ch211-106n13.2", "protein_names_uniprotkb": "Chemokine (C-C motif) receptor 12a", "protein_names_refseq": "chemokine (C-C motif) receptor 12.3; chemokine (C-C motif) receptor 12a; zfCCR3-3", "tax_id": 7955, "disease": "", "pathway": " (dre:563803)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19022503;26469318;27189481;28242321;28351983;31006648", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CA787477.1, GFIL01003401.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476731, SAMEA4476734 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Sep 1, 2006 this sequence version replaced XP_692258.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LYI4", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BFR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BFU7-1", "uniprot_id": "A0A8M2BFU7_DANRE", "mass": 37880.0, "length": 329, "protein_name": "N-arachidonyl glycine receptor", "gene_name": "gpr18", "organism": "Zebrafish", "refseq_name": "N-arachidonyl glycine receptor", "refseq_ac": "XP_005167836", "gene_names_uniprotkb": "gpr18", "gene_names_refseq": "gpr18", "protein_names_uniprotkb": "N-arachidonyl glycine receptor; G-protein coupled receptor 18", "protein_names_refseq": "N-arachidonyl glycine receptor", "tax_id": 7955, "disease": "", "pathway": " (dre:556711)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BFU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AL80-1", "uniprot_id": "A0A8M3AL80_DANRE", "mass": 125545.0, "length": 1122, "protein_name": "Anion exchange protein", "gene_name": "slc4a4b", "organism": "Zebrafish", "refseq_name": "electrogenic sodium bicarbonate cotransporter 1 isoform X1", "refseq_ac": "XP_009293410", "gene_names_uniprotkb": "slc4a4b", "gene_names_refseq": "slc4a4b", "protein_names_uniprotkb": "Anion exchange protein", "protein_names_refseq": "electrogenic sodium bicarbonate cotransporter 1 isoform X1", "tax_id": 7955, "disease": "proximal renal tubular acidosis-ocular anomaly syndrome (Disease Ontology:DOID:0061195); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); renal tubular acidosis (Disease Ontology:DOID:14219); anemia (Disease Ontology:DOID:2355); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (dre:561618)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AL80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHW0-1", "uniprot_id": "A0A8M2BHW0_DANRE", "mass": 92347.0, "length": 836, "protein_name": "Semaphorin-4A isoform X1", "gene_name": "sema4ab", "organism": "Zebrafish", "refseq_name": "semaphorin-4A isoform X1", "refseq_ac": "XP_005170153", "gene_names_uniprotkb": "sema4ab", "gene_names_refseq": "sema4ab", "protein_names_uniprotkb": "Semaphorin-4A isoform X1", "protein_names_refseq": "semaphorin-4A isoform X1", "tax_id": 7955, "disease": "retinitis pigmentosa 35 (Disease Ontology:DOID:0110357); cone-rod dystrophy 10 (Disease Ontology:DOID:0111017)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58I0T7", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007411 axon guidance;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJN6-1", "uniprot_id": "A0A8M3AJN6_DANRE", "mass": 123496.0, "length": 1117, "protein_name": "Protein phosphatase 1, regulatory subunit 13Ba isoform X1", "gene_name": "ppp1r13ba", "organism": "Zebrafish", "refseq_name": "protein phosphatase 1, regulatory subunit 13Ba isoform X1", "refseq_ac": "XP_009291162", "gene_names_uniprotkb": "ppp1r13ba; cb375; fc63g02; fc76b12; sb:cb375; si:ch73-9j13.1; wu:fa02c01; wu:fb69g10; wu:fc63g02; wu:fc76b12", "gene_names_refseq": "cb375; fc63g02; fc76b12; ppp1r13ba; sb:cb375; si:ch73-9j13.1; wu:fa02c01; wu:fb69g10; wu:fc63g02; wu:fc76b12", "protein_names_uniprotkb": "Protein phosphatase 1, regulatory subunit 13Ba isoform X1", "protein_names_refseq": "protein phosphatase 1, regulatory subunit 13Ba isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563577)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22438865;24422634;26469318;28252024", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M3AJN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ81-1", "uniprot_id": "A0A8M2BJ81_DANRE", "mass": 194698.0, "length": 1723, "protein_name": "Transient receptor potential cation channel subfamily M member 3 isoform X13", "gene_name": "trpm3", "organism": "Zebrafish", "refseq_name": "transient receptor potential cation channel subfamily M member 3 isoform X13", "refseq_ac": "XP_005171985", "gene_names_uniprotkb": "trpm3", "gene_names_refseq": "trpm3", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 3 isoform X13", "protein_names_refseq": "transient receptor potential cation channel subfamily M member 3 isoform X13", "tax_id": 7955, "disease": "chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (dre:565807)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0051262 protein tetramerization;GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BI98-1", "uniprot_id": "A0A8M2BI98_DANRE", "mass": 50717.0, "length": 441, "protein_name": "Major histocompatibility complex class I ZDA isoform X1", "gene_name": "mhc1zda", "organism": "Zebrafish", "refseq_name": "major histocompatibility complex class I ZDA isoform X1", "refseq_ac": "XP_005171048", "gene_names_uniprotkb": "mhc1zda", "gene_names_refseq": "mhc1zda", "protein_names_uniprotkb": "Major histocompatibility complex class I ZDA isoform X1", "protein_names_refseq": "major histocompatibility complex class I ZDA isoform X1", "tax_id": 7955, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); cardiomyopathy (Disease Ontology:DOID:0050700); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); graft-versus-host disease (Disease Ontology:DOID:0081267); hemochromatosis type 1 (Disease Ontology:DOID:0111029); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); iron deficiency anemia (Disease Ontology:DOID:11758); otosclerosis (Disease Ontology:DOID:12185); beta thalassemia (Disease Ontology:DOID:12241); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); colon cancer (Disease Ontology:DOID:219); hemochromatosis (Disease Ontology:DOID:2352); ovarian cancer (Disease Ontology:DOID:2394); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); acute kidney failure (Disease Ontology:DOID:3021); porphyria cutanea tarda (Disease Ontology:DOID:3132); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); thrombophlebitis (Disease Ontology:DOID:3875); lung adenocarcinoma (Disease Ontology:DOID:3910); tuberculosis (Disease Ontology:DOID:399); liver disease (Disease Ontology:DOID:409); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); myositis (Disease Ontology:DOID:633); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic kidney disease (Disease Ontology:DOID:784); osteoarthritis (Disease Ontology:DOID:8398); intestinal obstruction (Disease Ontology:DOID:8437); polymyalgia rheumatica (Disease Ontology:DOID:853); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005171048.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 95, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BI98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANJ7-1", "uniprot_id": "A0A8M3ANJ7_DANRE", "mass": 182006.0, "length": 1635, "protein_name": "LIM domain-containing protein isoform X1", "gene_name": "LOC556668", "organism": "Zebrafish", "refseq_name": "LIM domain-containing protein isoform X1", "refseq_ac": "XP_009295676", "gene_names_uniprotkb": "LOC556668", "gene_names_refseq": "LOC556668", "protein_names_uniprotkb": "LIM domain-containing protein isoform X1", "protein_names_refseq": "LIM domain-containing protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556668)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0070161 anchoring junction", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ANJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJF7-1", "uniprot_id": "A0A8M3AJF7_DANRE", "mass": 118127.0, "length": 1065, "protein_name": "FERM domain-containing protein 4A isoform X1", "gene_name": "frmd4a", "organism": "Zebrafish", "refseq_name": "FERM domain-containing protein 4A isoform X1", "refseq_ac": "XP_009291718", "gene_names_uniprotkb": "frmd4a; si:ch211-220f12.1; slc12a1", "gene_names_refseq": "frmd4a; si:ch211-220f12.1; slc12a1", "protein_names_uniprotkb": "FERM domain-containing protein 4A isoform X1", "protein_names_refseq": "FERM domain-containing protein 4A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:564713)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21270795;26469318;28252024;32106888;39021799", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0090162 establishment of epithelial cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3AJF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ02-1", "uniprot_id": "A0A8M2BJ02_DANRE", "mass": 84294.0, "length": 794, "protein_name": "Microtubule-associated protein", "gene_name": "map4l", "organism": "Zebrafish", "refseq_name": "uncharacterized protein map4l isoform X1", "refseq_ac": "XP_005171302", "gene_names_uniprotkb": "map4l", "gene_names_refseq": "map4l", "protein_names_uniprotkb": "Microtubule-associated protein", "protein_names_refseq": "uncharacterized protein map4l isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100537884)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AIZ5-1", "uniprot_id": "A0A8M3AIZ5_DANRE", "mass": 202738.0, "length": 1879, "protein_name": "Collagen alpha-1(XIV) chain isoform X1", "gene_name": "col14a1a", "organism": "Zebrafish", "refseq_name": "collagen alpha-1(XIV) chain isoform X1", "refseq_ac": "XP_009290436", "gene_names_uniprotkb": "col14a1a", "gene_names_refseq": "col14a1a", "protein_names_uniprotkb": "Collagen alpha-1(XIV) chain isoform X1", "protein_names_refseq": "collagen alpha-1(XIV) chain isoform X1", "tax_id": 7955, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dre:321298)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290436.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005604 basement membrane;GO:0005614 interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0070831 basement membrane assembly;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AIZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKS3-1", "uniprot_id": "A0A8M2BKS3_DANRE", "mass": 282028.0, "length": 2632, "protein_name": "Protein capicua homolog", "gene_name": "cicb", "organism": "Zebrafish", "refseq_name": "protein capicua homolog isoform X1", "refseq_ac": "XP_005173569", "gene_names_uniprotkb": "cicb", "gene_names_refseq": "cicb", "protein_names_uniprotkb": "Protein capicua homolog", "protein_names_refseq": "protein capicua homolog isoform X1", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 45 (Disease Ontology:DOID:0080236); disease of mental health (Disease Ontology:DOID:150)", "pathway": " (dre:323246)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005173569.2. COMPLETENESS: full length., [RefSeq]; Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHE0-1", "uniprot_id": "A0A8M2BHE0_DANRE", "mass": 37019.0, "length": 316, "protein_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "gene_name": "c1galt1a", "organism": "Zebrafish", "refseq_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform X1", "refseq_ac": "XP_005170092", "gene_names_uniprotkb": "c1galt1a; si:dkey-202e17.1", "gene_names_refseq": "c1galt1a; si:dkey-202e17.1", "protein_names_uniprotkb": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; 2.4.1.122; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Core 1 beta1,3-galactosyltransferase 1", "protein_names_refseq": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:555344)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.122", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0000166 nucleotide binding;GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M2BHE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHH0-1", "uniprot_id": "A0A8M2BHH0_DANRE", "mass": 112085.0, "length": 994, "protein_name": "Gamma-aminobutyric acid type B receptor subunit 1 isoform X1", "gene_name": "gabbr1b", "organism": "Zebrafish", "refseq_name": "gamma-aminobutyric acid type B receptor subunit 1 isoform X1", "refseq_ac": "XP_005170159", "gene_names_uniprotkb": "gabbr1b", "gene_names_refseq": "gabbr1b", "protein_names_uniprotkb": "Gamma-aminobutyric acid type B receptor subunit 1 isoform X1", "protein_names_refseq": "gamma-aminobutyric acid type B receptor subunit 1 isoform X1", "tax_id": 7955, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); hypertension (Disease Ontology:DOID:10763); amphetamine abuse (Disease Ontology:DOID:670); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dre:558708)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004965 G protein-coupled GABA receptor activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0038039 G protein-coupled receptor heterodimeric complex", "go_biological_process": "GO:0035095 behavioral response to nicotine;GO:0007214 gamma-aminobutyric acid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ALJ2-1", "uniprot_id": "A0A8M3ALJ2_DANRE", "mass": 215834.0, "length": 1956, "protein_name": "Rho GTPase-activating protein 32", "gene_name": "arhgap32b", "organism": "Zebrafish", "refseq_name": "rho GTPase-activating protein 32 isoform X1", "refseq_ac": "XP_009293685", "gene_names_uniprotkb": "arhgap32b", "gene_names_refseq": "arhgap32b", "protein_names_uniprotkb": "Rho GTPase-activating protein 32; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS", "protein_names_refseq": "rho GTPase-activating protein 32 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (dre:569434)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0012505 endomembrane system", "go_biological_process": "GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0061001 regulation of dendritic spine morphogenesis;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ALJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHJ3-1", "uniprot_id": "A0A8M2BHJ3_DANRE", "mass": 50808.0, "length": 444, "protein_name": "Acid sphingomyelinase-like phosphodiesterase", "gene_name": "smpdl3a", "organism": "Zebrafish", "refseq_name": "cyclic GMP-AMP phosphodiesterase SMPDL3A isoform X1", "refseq_ac": "XP_005170233", "gene_names_uniprotkb": "smpdl3a; si:ch211-199i15.3; zgc:113352", "gene_names_refseq": "si:ch211-199i15.3; smpdl3a; zgc:113352", "protein_names_uniprotkb": "Acid sphingomyelinase-like phosphodiesterase", "protein_names_refseq": "cyclic GMP-AMP phosphodiesterase SMPDL3A isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0016787 hydrolase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006685 sphingomyelin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AMX3-1", "uniprot_id": "A0A8M3AMX3_DANRE", "mass": 62637.0, "length": 572, "protein_name": "Zinc finger protein Eos isoform X1", "gene_name": "ikzf4", "organism": "Zebrafish", "refseq_name": "zinc finger protein Eos isoform X1", "refseq_ac": "XP_005162323", "gene_names_uniprotkb": "ikzf4; eos; si:dkey-166n8.9", "gene_names_refseq": "eos; ikzf4; si:dkey-166n8.9", "protein_names_uniprotkb": "Zinc finger protein Eos isoform X1", "protein_names_refseq": "zinc finger protein Eos isoform X1", "tax_id": 7955, "disease": "encephalomyelitis (Disease Ontology:DOID:640)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1Q5C5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AMX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AP34-1", "uniprot_id": "A0A8M3AP34_DANRE", "mass": 92692.0, "length": 810, "protein_name": "A-type potassium channel modulatory protein DPP6", "gene_name": "dpp6a", "organism": "Zebrafish", "refseq_name": "A-type potassium channel modulatory protein DPP6 isoform X1", "refseq_ac": "XP_009295542", "gene_names_uniprotkb": "dpp6a", "gene_names_refseq": "dpp6a", "protein_names_uniprotkb": "A-type potassium channel modulatory protein DPP6; Dipeptidyl aminopeptidase-like protein 6; Dipeptidyl peptidase 6; Dipeptidyl peptidase VI", "protein_names_refseq": "A-type potassium channel modulatory protein DPP6 isoform X1", "tax_id": 7955, "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); spinal muscular atrophy (Disease Ontology:DOID:12377); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (dre:100007104)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009295542.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008236 serine-type peptidase activity;GO:0015459 potassium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0006508 proteolysis;GO:0034220 monoatomic ion transmembrane transport;GO:1901379 regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AP34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHU6-1", "uniprot_id": "A0A8M2BHU6_DANRE", "mass": 125715.0, "length": 1136, "protein_name": "Rho GTPase-activating protein 45 isoform X1", "gene_name": "arhgap45b", "organism": "Zebrafish", "refseq_name": "rho GTPase-activating protein 45 isoform X1", "refseq_ac": "XP_005170570", "gene_names_uniprotkb": "arhgap45b", "gene_names_refseq": "arhgap45b", "protein_names_uniprotkb": "Rho GTPase-activating protein 45 isoform X1", "protein_names_refseq": "rho GTPase-activating protein 45 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:555849)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3API9-1", "uniprot_id": "A0A8M3API9_DANRE", "mass": 207605.0, "length": 1800, "protein_name": "Unconventional myosin-Va isoform X2", "gene_name": "myo5ab", "organism": "Zebrafish", "refseq_name": "unconventional myosin-Va isoform X2", "refseq_ac": "XP_009296049", "gene_names_uniprotkb": "myo5ab", "gene_names_refseq": "myo5ab", "protein_names_uniprotkb": "Unconventional myosin-Va isoform X2", "protein_names_refseq": "unconventional myosin-Va isoform X2", "tax_id": 7955, "disease": "Griscelli syndrome type 1 (Disease Ontology:DOID:0060832)", "pathway": " (dre:565267)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009296049.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0003824 catalytic activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0016459 myosin complex;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0048731 system development;GO:0006897 endocytosis;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3API9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJ04-1", "uniprot_id": "A0A8M3AJ04_DANRE", "mass": 155771.0, "length": 1412, "protein_name": "Rho guanine nucleotide exchange factor 10", "gene_name": "arhgef10", "organism": "Zebrafish", "refseq_name": "rho guanine nucleotide exchange factor 10 isoform X1", "refseq_ac": "XP_009291354", "gene_names_uniprotkb": "arhgef10", "gene_names_refseq": "arhgef10", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 10", "protein_names_refseq": "rho guanine nucleotide exchange factor 10 isoform X1", "tax_id": 7955, "disease": "alcohol-related birth defects (Disease Ontology:DOID:0050668); autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (dre:334278)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009291354.1. COMPLETENESS: full length., [RefSeq]; May play a role in developmental myelination of peripheral nerves., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0051496 positive regulation of stress fiber assembly;GO:0036269 swimming behavior;GO:0090307 mitotic spindle assembly;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ04-1", "uniprot_id": "A0A8M2BJ04_DANRE", "mass": 49950.0, "length": 457, "protein_name": "Pre-B-cell leukemia transcription factor 1 isoform X1", "gene_name": "pbx3a", "organism": "Zebrafish", "refseq_name": "pre-B-cell leukemia transcription factor 1 isoform X1", "refseq_ac": "XP_005171793", "gene_names_uniprotkb": "pbx3a", "gene_names_refseq": "pbx3a", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 1 isoform X1", "protein_names_refseq": "pre-B-cell leukemia transcription factor 1 isoform X1", "tax_id": 7955, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dre:387532)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0009887 animal organ morphogenesis;GO:0048666 neuron development;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH24-1", "uniprot_id": "A0A8M2BH24_DANRE", "mass": 54049.0, "length": 536, "protein_name": "Macrophage receptor MARCO isoform X1", "gene_name": "marco", "organism": "Zebrafish", "refseq_name": "macrophage receptor MARCO isoform X1", "refseq_ac": "XP_005169179", "gene_names_uniprotkb": "marco", "gene_names_refseq": "marco", "protein_names_uniprotkb": "Macrophage receptor MARCO isoform X1", "protein_names_refseq": "macrophage receptor MARCO isoform X1", "tax_id": 7955, "disease": "meningococcal meningitis (Disease Ontology:DOID:0080176); silicosis (Disease Ontology:DOID:10325); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (dre:571584)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJ29-1", "uniprot_id": "A0A8M3AJ29_DANRE", "mass": 93124.0, "length": 830, "protein_name": "Metal transporter", "gene_name": "cnnm2b", "organism": "Zebrafish", "refseq_name": "metal transporter CNNM2 isoform X1", "refseq_ac": "XP_009290541", "gene_names_uniprotkb": "cnnm2b", "gene_names_refseq": "cnnm2b", "protein_names_uniprotkb": "Metal transporter", "protein_names_refseq": "metal transporter CNNM2 isoform X1", "tax_id": 7955, "disease": "renal hypomagnesemia 6 (Disease Ontology:DOID:0060884); schizophrenia (Disease Ontology:DOID:5419)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290541.1. COMPLETENESS: full length., [RefSeq]; Metal transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007420 brain development;GO:0010960 magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJ29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIJ1-1", "uniprot_id": "A0A8M2BIJ1_DANRE", "mass": 63656.0, "length": 573, "protein_name": "MLLT1 super elongation complex subunit b isoform X1", "gene_name": "mllt1b", "organism": "Zebrafish", "refseq_name": "MLLT1 super elongation complex subunit b isoform X1", "refseq_ac": "XP_005171269", "gene_names_uniprotkb": "mllt1b; wu:fj79f01; zgc:136639", "gene_names_refseq": "mllt1b; wu:fj79f01; zgc:136639", "protein_names_uniprotkb": "MLLT1 super elongation complex subunit b isoform X1", "protein_names_refseq": "MLLT1 super elongation complex subunit b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGT5-1", "uniprot_id": "A0A8M2BGT5_DANRE", "mass": 84484.0, "length": 751, "protein_name": "Leucine-rich repeat flightless-interacting protein 2", "gene_name": "lrrfip2", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat flightless-interacting protein 2 isoform X1", "refseq_ac": "XP_005169574", "gene_names_uniprotkb": "lrrfip2; wu:fj34c02; zgc:113956; zgc:63771", "gene_names_refseq": "lrrfip2; wu:fj34c02; zgc:113956; zgc:63771", "protein_names_uniprotkb": "Leucine-rich repeat flightless-interacting protein 2", "protein_names_refseq": "leucine-rich repeat flightless-interacting protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:335838)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19240133;21925157;25504979;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M2BGT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHC1-1", "uniprot_id": "A0A8M2BHC1_DANRE", "mass": 48221.0, "length": 416, "protein_name": "Cytohesin-1b isoform X1", "gene_name": "cyth1b", "organism": "Zebrafish", "refseq_name": "cytohesin-1b isoform X1", "refseq_ac": "XP_005169523", "gene_names_uniprotkb": "cyth1b; fc89h04; wu:fc89h04; zgc:73134", "gene_names_refseq": "cyth1b; fc89h04; wu:fc89h04; zgc:73134", "protein_names_uniprotkb": "Cytohesin-1b isoform X1", "protein_names_refseq": "cytohesin-1b isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032012 regulation of ARF protein signal transduction;GO:0055113 epiboly involved in gastrulation with mouth forming second;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BHC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIK5-1", "uniprot_id": "A0A8M2BIK5_DANRE", "mass": 99921.0, "length": 893, "protein_name": "Small conductance calcium-activated potassium channel protein 1a isoform X1", "gene_name": "kcnn1a", "organism": "Zebrafish", "refseq_name": "small conductance calcium-activated potassium channel protein 1a isoform X1", "refseq_ac": "XP_005171293", "gene_names_uniprotkb": "kcnn1a; si:rp71-39b20.3", "gene_names_refseq": "kcnn1a; si:rp71-39b20.3", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 1a isoform X1", "protein_names_refseq": "small conductance calcium-activated potassium channel protein 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:563352)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "26469318;27189481;29412518;31031593;33203744;33728688", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0016286 small conductance calcium-activated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0030018 Z disc", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BIK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGM9-1", "uniprot_id": "A0A8M2BGM9_DANRE", "mass": 114953.0, "length": 1023, "protein_name": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3", "gene_name": "unm_sa1614", "organism": "Zebrafish", "refseq_name": "arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2", "refseq_ac": "XP_005169383", "gene_names_uniprotkb": "unm_sa1614", "gene_names_refseq": "unm_sa1614", "protein_names_uniprotkb": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; Development and differentiation-enhancing factor-like 1", "protein_names_refseq": "arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:561879)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005169383.1. COMPLETENESS: full length., [RefSeq]; Promotes cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ALB2-1", "uniprot_id": "A0A8M3ALB2_DANRE", "mass": 87851.0, "length": 845, "protein_name": "Calpastatin", "gene_name": "cast", "organism": "Zebrafish", "refseq_name": "calpastatin isoform X1", "refseq_ac": "XP_009293484", "gene_names_uniprotkb": "cast; sb:cb966; zgc:194249", "gene_names_refseq": "cast; sb:cb966; zgc:194249", "protein_names_uniprotkb": "Calpastatin; Calpain inhibitor", "protein_names_refseq": "calpastatin isoform X1", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); PLACK syndrome (Disease Ontology:DOID:0070526); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Sjogren's syndrome (Disease Ontology:DOID:12894); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767); vasculitis (Disease Ontology:DOID:865); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dre:563084)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15520368;15990347;17643392;18265014;26214419;26908177;27189481;28076796;28252024;28926587;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A0A8M3ALB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AI27-1", "uniprot_id": "A0A8M3AI27_DANRE", "mass": 132356.0, "length": 1211, "protein_name": "Protocadherin-1 isoform X1", "gene_name": "pcdh1b", "organism": "Zebrafish", "refseq_name": "protocadherin-1 isoform X1", "refseq_ac": "XP_073778217", "gene_names_uniprotkb": "pcdh1b", "gene_names_refseq": "pcdh1b", "protein_names_uniprotkb": "Protocadherin-1 isoform X1", "protein_names_refseq": "protocadherin-1 isoform X1", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); intrinsic asthma (Disease Ontology:DOID:9360)", "pathway": " (dre:572016)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H8A1;E7F376", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009653 anatomical structure morphogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AI27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BL82-1", "uniprot_id": "A0A8M2BL82_DANRE", "mass": 62018.0, "length": 542, "protein_name": "procollagen-proline 4-dioxygenase", "gene_name": "p4ha2", "organism": "Zebrafish", "refseq_name": "prolyl 4-hydroxylase subunit alpha-2 isoform X1", "refseq_ac": "XP_005173949", "gene_names_uniprotkb": "p4ha2; zgc:91948", "gene_names_refseq": "p4ha2; zgc:91948", "protein_names_uniprotkb": "procollagen-proline 4-dioxygenase; 1.14.11.2", "protein_names_refseq": "prolyl 4-hydroxylase subunit alpha-2 isoform X1", "tax_id": 7955, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BL82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH55-1", "uniprot_id": "A0A8M2BH55_DANRE", "mass": 64347.0, "length": 575, "protein_name": "Potassium channel subfamily K member 10b isoform X1", "gene_name": "kcnk10b", "organism": "Zebrafish", "refseq_name": "potassium channel subfamily K member 10b isoform X1", "refseq_ac": "XP_005169840", "gene_names_uniprotkb": "kcnk10b; k2p10.1; si:ch211-51o12.3; trek2b", "gene_names_refseq": "k2p10.1; kcnk10b; si:ch211-51o12.3; trek2b", "protein_names_uniprotkb": "Potassium channel subfamily K member 10b isoform X1", "protein_names_refseq": "potassium channel subfamily K member 10b isoform X1", "tax_id": 7955, "disease": "heart conduction disease (Disease Ontology:DOID:10273); brain ischemia (Disease Ontology:DOID:2316)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0005267 potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJE0-1", "uniprot_id": "A0A8M2BJE0_DANRE", "mass": 37011.0, "length": 320, "protein_name": "Syntaxin-16", "gene_name": "stx16", "organism": "Zebrafish", "refseq_name": "syntaxin-16 isoform X1", "refseq_ac": "XP_005172174", "gene_names_uniprotkb": "stx16", "gene_names_refseq": "stx16", "protein_names_uniprotkb": "Syntaxin-16", "protein_names_refseq": "syntaxin-16 isoform X1", "tax_id": 7955, "disease": "pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222)", "pathway": " (dre:562857)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0039023 pronephric duct morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AND6-1", "uniprot_id": "A0A8M3AND6_DANRE", "mass": 56123.0, "length": 522, "protein_name": "Abl interactor 1a isoform X1", "gene_name": "abi1a", "organism": "Zebrafish", "refseq_name": "abl interactor 1a isoform X1", "refseq_ac": "XP_009295502", "gene_names_uniprotkb": "abi1a; abi1; wu:fc66g09; wu:fk56a10; zgc:73174", "gene_names_refseq": "abi1a; abi1; wu:fc66g09; wu:fk56a10; zgc:73174", "protein_names_uniprotkb": "Abl interactor 1a isoform X1", "protein_names_refseq": "abl interactor 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:393711)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19439512;26161877;26469318;27189481;28252024;28871129;32368696", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0031209 SCAR complex;GO:0098858 actin-based cell projection", "go_biological_process": "GO:0001764 neuron migration;GO:0048858 cell projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M3AND6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLQ3-1", "uniprot_id": "A0A8M2BLQ3_DANRE", "mass": 54366.0, "length": 494, "protein_name": "Sugar phosphate exchanger 3", "gene_name": "slc37a3", "organism": "Zebrafish", "refseq_name": "sugar phosphate exchanger 3 isoform X1", "refseq_ac": "XP_068073927", "gene_names_uniprotkb": "slc37a3", "gene_names_refseq": "slc37a3", "protein_names_uniprotkb": "Sugar phosphate exchanger 3; Solute carrier family 37 member 3", "protein_names_refseq": "sugar phosphate exchanger 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100331554)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2L9U9", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGK1-1", "uniprot_id": "A0A8M2BGK1_DANRE", "mass": 81871.0, "length": 742, "protein_name": "Segment polarity protein dishevelled homolog DVL-1b isoform X1", "gene_name": "dvl1b", "organism": "Zebrafish", "refseq_name": "segment polarity protein dishevelled homolog DVL-1b isoform X1", "refseq_ac": "XP_005169354", "gene_names_uniprotkb": "dvl1b; dvl1; dvl2l", "gene_names_refseq": "dvl1b; dvl1; dvl2l", "protein_names_uniprotkb": "Segment polarity protein dishevelled homolog DVL-1b isoform X1", "protein_names_refseq": "segment polarity protein dishevelled homolog DVL-1b isoform X1", "tax_id": 7955, "disease": "autosomal dominant Robinow syndrome 2 (Disease Ontology:DOID:0060765); DiGeorge syndrome (Disease Ontology:DOID:11198); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dre:560032)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21074723;21610036;21911385;22814267;22927466;26469318;27189481;28258112;30080849;31816052", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005169354.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BGK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH61-1", "uniprot_id": "A0A8M2BH61_DANRE", "mass": 76963.0, "length": 685, "protein_name": "VPS9 domain-containing protein 1 isoform X1", "gene_name": "vps9d1", "organism": "Zebrafish", "refseq_name": "VPS9 domain-containing protein 1 isoform X1", "refseq_ac": "XP_068070863", "gene_names_uniprotkb": "vps9d1; c18h16orf7; id:ibd5127; wu:fa56d01; zgc:113159; zgc:158780", "gene_names_refseq": "c18h16orf7; id:ibd5127; vps9d1; wu:fa56d01; zgc:113159; zgc:158780", "protein_names_uniprotkb": "VPS9 domain-containing protein 1 isoform X1", "protein_names_refseq": "VPS9 domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:503773)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11731487;23720042;26469318;27189481;32423473;36314606", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BH61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AH76-1", "uniprot_id": "A0A8M3AH76_DANRE", "mass": 46819.0, "length": 417, "protein_name": "PC4 and SFRS1 interacting protein 1a isoform X1", "gene_name": "psip1a", "organism": "Zebrafish", "refseq_name": "PC4 and SFRS1 interacting protein 1a isoform X1", "refseq_ac": "XP_073800478", "gene_names_uniprotkb": "psip1a; im:7149861; psip1; zgc:109898", "gene_names_refseq": "im:7149861; psip1a; psip1; zgc:109898", "protein_names_uniprotkb": "PC4 and SFRS1 interacting protein 1a isoform X1", "protein_names_refseq": "PC4 and SFRS1 interacting protein 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:553760)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17993506;24240475;27189481;35504924", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58J1W8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8M3AH76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKU4-1", "uniprot_id": "A0A8M2BKU4_DANRE", "mass": 46429.0, "length": 407, "protein_name": "DEP domain-containing mTOR-interacting protein isoform X1", "gene_name": "deptor", "organism": "Zebrafish", "refseq_name": "DEP domain-containing mTOR-interacting protein", "refseq_ac": "NP_001429285", "gene_names_uniprotkb": "deptor; depdc6; fd14h03; fi11e09; wu:fd14h03; wu:fi11e09; zgc:152943", "gene_names_refseq": "depdc6; deptor; fd14h03; fi11e09; wu:fd14h03; wu:fi11e09; zgc:152943", "protein_names_uniprotkb": "DEP domain-containing mTOR-interacting protein isoform X1", "protein_names_refseq": "DEP domain containing 6; DEP domain-containing mTOR-interacting protein", "tax_id": 7955, "disease": "", "pathway": " (dre:768177)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15520368;23072875;26469318;27189481;35134499", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588729.9488152.1, SRR32588724.893254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000016.1. On Aug 3, 2025 this sequence version replaced XP_005173581.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1Q589", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0032007 negative regulation of TOR signaling;GO:0007186 G protein-coupled receptor signaling pathway;GO:1904262 negative regulation of TORC1 signaling;GO:1903940 negative regulation of TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BKU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJA1-1", "uniprot_id": "A0A8M3AJA1_DANRE", "mass": 34144.0, "length": 310, "protein_name": "Low-density lipoprotein receptor class A domain-containing protein 4b isoform X1", "gene_name": "ldlrad4b", "organism": "Zebrafish", "refseq_name": "low-density lipoprotein receptor class A domain-containing protein 4b isoform X1", "refseq_ac": "XP_009290741", "gene_names_uniprotkb": "ldlrad4b; gb:al921110; si:dkey-199k9.3", "gene_names_refseq": "gb:al921110; ldlrad4b; si:dkey-199k9.3", "protein_names_uniprotkb": "Low-density lipoprotein receptor class A domain-containing protein 4b isoform X1", "protein_names_refseq": "low-density lipoprotein receptor class A domain-containing protein 4b isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556780)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0031901 early endosome membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8M3AJA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AHZ5-1", "uniprot_id": "A0A8M3AHZ5_DANRE", "mass": 109738.0, "length": 985, "protein_name": "C-Jun-amino-terminal kinase-interacting protein 4 isoform X1", "gene_name": "si:dkey-17m8.1", "organism": "Zebrafish", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 4 isoform X1", "refseq_ac": "XP_073782101", "gene_names_uniprotkb": "si:dkey-17m8.1", "gene_names_refseq": "si:dkey-17m8.1", "protein_names_uniprotkb": "C-Jun-amino-terminal kinase-interacting protein 4 isoform X1", "protein_names_refseq": "C-Jun-amino-terminal kinase-interacting protein 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:796618)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HJA2", "ec_number_list": "", "go_molecular_function": "GO:0005078 MAP-kinase scaffold activity;GO:0016301 kinase activity;GO:0019894 kinesin binding;GO:0030159 signaling receptor complex adaptor activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AHZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGV5-1", "uniprot_id": "A0A8M2BGV5_DANRE", "mass": 79146.0, "length": 705, "protein_name": "MBT domain-containing protein 1 isoform X1", "gene_name": "mbtd1", "organism": "Zebrafish", "refseq_name": "MBT domain-containing protein 1 isoform X1", "refseq_ac": "XP_005169539", "gene_names_uniprotkb": "mbtd1", "gene_names_refseq": "mbtd1", "protein_names_uniprotkb": "MBT domain-containing protein 1 isoform X1", "protein_names_refseq": "MBT domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:568340)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133187) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005169539.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AMN7-1", "uniprot_id": "A0A8M3AMN7_DANRE", "mass": 236268.0, "length": 2138, "protein_name": "Plexin-B1", "gene_name": "plxnb1a", "organism": "Zebrafish", "refseq_name": "plexin-B1 isoform X1", "refseq_ac": "XP_073795940", "gene_names_uniprotkb": "plxnb1a", "gene_names_refseq": "plxnb1a", "protein_names_uniprotkb": "Plexin-B1", "protein_names_refseq": "plexin-B1 isoform X1", "tax_id": 7955, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:561012)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58INX3", "ec_number_list": "", "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0008360 regulation of cell shape;GO:0007411 axon guidance;GO:0048675 axon extension;GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AMN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH26-1", "uniprot_id": "A0A8M2BH26_DANRE", "mass": 203544.0, "length": 1822, "protein_name": "Kinesin-like protein KIF13B isoform X1", "gene_name": "kif13ba", "organism": "Zebrafish", "refseq_name": "kinesin-like protein KIF13B isoform X1", "refseq_ac": "XP_005169924", "gene_names_uniprotkb": "kif13ba", "gene_names_refseq": "kif13ba", "protein_names_uniprotkb": "Kinesin-like protein KIF13B isoform X1", "protein_names_refseq": "kinesin-like protein KIF13B isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:571520)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0048731 system development;GO:0045184 establishment of protein localization;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKM7-1", "uniprot_id": "A0A8M2BKM7_DANRE", "mass": 15094.0, "length": 134, "protein_name": "Complexin-1", "gene_name": "cplx1; cplx2b", "organism": "Zebrafish", "refseq_name": "complexin-1", "refseq_ac": "XP_691535", "gene_names_uniprotkb": "cplx1; cplx2b; cplx2; wu:fc27b12", "gene_names_refseq": "cplx1", "protein_names_uniprotkb": "Complexin-1", "protein_names_refseq": "complexin-1", "tax_id": 7955, "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:556701); (dre:563082)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19240126;23658160;26011545;26469318;26950095;27189481;31434971;31712630", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_691535.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FBR8", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043204 perikaryon;GO:0098793 presynapse;GO:0043195 terminal bouton", "go_biological_process": "GO:0006887 exocytosis;GO:0006836 neurotransmitter transport;GO:0050804 modulation of chemical synaptic transmission;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2BKM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AKH8-1", "uniprot_id": "A0A8M3AKH8_DANRE", "mass": 190487.0, "length": 1738, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "mast1a", "organism": "Zebrafish", "refseq_name": "microtubule-associated serine/threonine-protein kinase 1 isoform X1", "refseq_ac": "XP_009292706", "gene_names_uniprotkb": "mast1a", "gene_names_refseq": "mast1a", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 1 isoform X1", "tax_id": 7955, "disease": "female breast cancer (Disease Ontology:DOID:0050671); mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations (Disease Ontology:DOID:0111403)", "pathway": " (dre:796739)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0032502 developmental process;GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AKH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANG1-1", "uniprot_id": "A0A8M3ANG1_DANRE", "mass": 42190.0, "length": 384, "protein_name": "Protein NDRG3b isoform X2", "gene_name": "ndrg3b", "organism": "Zebrafish", "refseq_name": "protein NDRG3b isoform X2", "refseq_ac": "XP_009294964", "gene_names_uniprotkb": "ndrg3b; NDRG3; fi05h10; wu:fi05h10; zgc:55301", "gene_names_refseq": "NDRG3; fi05h10; ndrg3b; wu:fi05h10; zgc:55301", "protein_names_uniprotkb": "Protein NDRG3b isoform X2", "protein_names_refseq": "protein NDRG3b isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:327395)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IJ09", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ANG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AHW0-1", "uniprot_id": "A0A8M3AHW0_DANRE", "mass": 80777.0, "length": 718, "protein_name": "Probable E3 ubiquitin-protein ligase MID2 isoform X1", "gene_name": "mid2", "organism": "Zebrafish", "refseq_name": "probable E3 ubiquitin-protein ligase MID2 isoform X1", "refseq_ac": "XP_009289348", "gene_names_uniprotkb": "mid2", "gene_names_refseq": "mid2", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase MID2 isoform X1", "protein_names_refseq": "probable E3 ubiquitin-protein ligase MID2 isoform X1", "tax_id": 7955, "disease": "non-syndromic X-linked intellectual disability 101 (Disease Ontology:DOID:0112048)", "pathway": " (dre:799891)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016740 transferase activity;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AHW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AM67-1", "uniprot_id": "A0A8M3AM67_DANRE", "mass": 59351.0, "length": 527, "protein_name": "NGFI-A-binding protein 1a isoform X1", "gene_name": "nab1a", "organism": "Zebrafish", "refseq_name": "NGFI-A-binding protein 1a isoform X1", "refseq_ac": "XP_009294480", "gene_names_uniprotkb": "nab1a; nab1; si:dkeyp-84a8.1", "gene_names_refseq": "nab1a; nab1; si:dkeyp-84a8.1", "protein_names_uniprotkb": "NGFI-A-binding protein 1a isoform X1", "protein_names_refseq": "NGFI-A-binding protein 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565795)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21669877;21787765;22412924;26469318;27189481;31053140", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M3AM67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGK9-1", "uniprot_id": "A0A8M2BGK9_DANRE", "mass": 68123.0, "length": 598, "protein_name": "Leucine-rich repeat flightless-interacting protein 2 isoform X1", "gene_name": "lrrfip1b", "organism": "Zebrafish", "refseq_name": "leucine-rich repeat flightless-interacting protein 2 isoform X1", "refseq_ac": "XP_005168781", "gene_names_uniprotkb": "lrrfip1b", "gene_names_refseq": "lrrfip1b", "protein_names_uniprotkb": "Leucine-rich repeat flightless-interacting protein 2 isoform X1", "protein_names_refseq": "leucine-rich repeat flightless-interacting protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100321881)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH47-1", "uniprot_id": "A0A8M2BH47_DANRE", "mass": 59930.0, "length": 539, "protein_name": "Copine-3", "gene_name": "cpne1", "organism": "Zebrafish", "refseq_name": "copine-1 isoform X1", "refseq_ac": "XP_005169314", "gene_names_uniprotkb": "cpne1; cpne3l; cpne3; wu:fb69d07; wu:fc45a04; zgc:55873", "gene_names_refseq": "cpne1; cpne3l; cpne3; wu:fb69d07; wu:fc45a04; zgc:55873", "protein_names_uniprotkb": "Copine-3; Copine III", "protein_names_refseq": "copine-1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:324841)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18831769;25534026;26469318;27189481;28252024;31726584", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005169314.1. COMPLETENESS: full length., [RefSeq]; Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0043122 regulation of canonical NF-kappaB signal transduction;GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8M2BH47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGK5-1", "uniprot_id": "A0A8M2BGK5_DANRE", "mass": 66428.0, "length": 575, "protein_name": "Melanophilin a isoform X1", "gene_name": "mlpha", "organism": "Zebrafish", "refseq_name": "melanophilin a isoform X1", "refseq_ac": "XP_073809160", "gene_names_uniprotkb": "mlpha; mlphb; si:ch211-186m12.3; zgc:154096", "gene_names_refseq": "mlpha; mlphb; si:ch211-186m12.3; zgc:154096", "protein_names_uniprotkb": "Melanophilin a isoform X1", "protein_names_refseq": "melanophilin a isoform X1", "tax_id": 7955, "disease": "Griscelli syndrome type 3 (Disease Ontology:DOID:0060834)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JRP5", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0017022 myosin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0051876 pigment granule dispersal", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGM3-1", "uniprot_id": "A0A8M2BGM3_DANRE", "mass": 231951.0, "length": 2051, "protein_name": "ribonuclease H", "gene_name": "LOC101886558", "organism": "Zebrafish", "refseq_name": "uncharacterized protein", "refseq_ac": "XP_005168841", "gene_names_uniprotkb": "LOC101886558", "gene_names_refseq": "LOC101886558", "protein_names_uniprotkb": "ribonuclease H; 3.1.26.4", "protein_names_refseq": "uncharacterized protein", "tax_id": 7955, "disease": "", "pathway": " (dre:101886558)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005168841.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "", "go_biological_process": "GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGM4-1", "uniprot_id": "A0A8M2BGM4_DANRE", "mass": 87883.0, "length": 794, "protein_name": "Zinc finger CCCH domain-containing protein 11A isoform X1", "gene_name": "zc3h11a", "organism": "Zebrafish", "refseq_name": "zinc finger CCCH domain-containing protein 11A isoform X1", "refseq_ac": "XP_073771611", "gene_names_uniprotkb": "zc3h11a; fc32e10; wu:fc32e10; zgc:73328", "gene_names_refseq": "fc32e10; wu:fc32e10; zc3h11a; zgc:73328", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 11A isoform X1", "protein_names_refseq": "zinc finger CCCH domain-containing protein 11A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:324551); (R-DRE-159236)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58GPE8;A0AC58GPF1;F1QNW1", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BGM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGR8-1", "uniprot_id": "A0A8M2BGR8_DANRE", "mass": 108539.0, "length": 930, "protein_name": "Anoctamin", "gene_name": "ano5b", "organism": "Zebrafish", "refseq_name": "anoctamin-5b isoform X1", "refseq_ac": "XP_005168948", "gene_names_uniprotkb": "ano5b; Gdd1; si:packt73.3; si:packt90.1; si:xx-packt90.1; wu:fb74d12; zgc:158430", "gene_names_refseq": "Gdd1; ano5b; si:packt73.3; si:packt90.1; si:xx-packt90.1; wu:fb74d12; zgc:158430", "protein_names_uniprotkb": "Anoctamin", "protein_names_refseq": "anoctamin-5b isoform X1", "tax_id": 7955, "disease": "Miyoshi muscular dystrophy 3 (Disease Ontology:DOID:0070201); autosomal recessive limb-girdle muscular dystrophy type 2L (Disease Ontology:DOID:0110284); isolated elevated serum creatine phosphokinase levels (Disease Ontology:DOID:0111338); gnathodiaphyseal dysplasia (Disease Ontology:DOID:0111533)", "pathway": " (dre:560102)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18850331;26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BGR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGW0-1", "uniprot_id": "A0A8M2BGW0_DANRE", "mass": 207415.0, "length": 1861, "protein_name": "TATA-binding protein-associated factor 172", "gene_name": "btaf1", "organism": "Zebrafish", "refseq_name": "TATA-binding protein-associated factor 172", "refseq_ac": "XP_005169589", "gene_names_uniprotkb": "btaf1", "gene_names_refseq": "btaf1", "protein_names_uniprotkb": "TATA-binding protein-associated factor 172", "protein_names_refseq": "TATA-binding protein-associated factor 172", "tax_id": 7955, "disease": "", "pathway": " (dre:565357)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133188) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGX7-1", "uniprot_id": "A0A8M2BGX7_DANRE", "mass": 23054.0, "length": 217, "protein_name": "Claudin", "gene_name": "cldn5c", "organism": "Zebrafish", "refseq_name": "claudin-4", "refseq_ac": "XP_005169737", "gene_names_uniprotkb": "cldn5c; LOC100333734", "gene_names_refseq": "LOC100333734", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "claudin-4", "tax_id": 7955, "disease": "", "pathway": " (dre:100333734)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0160184 paracellular transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BGZ5-1", "uniprot_id": "A0A8M2BGZ5_DANRE", "mass": 28159.0, "length": 250, "protein_name": "Fibroblast growth factor", "gene_name": "fgf12b", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005169785", "gene_names_uniprotkb": "fgf12b; zgc:153120", "gene_names_refseq": "fgf12b; zgc:153120", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BGZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH03-1", "uniprot_id": "A0A8M2BH03_DANRE", "mass": 40023.0, "length": 361, "protein_name": "GDP-fucose transporter 1 isoform X1", "gene_name": "slc35c1", "organism": "Zebrafish", "refseq_name": "GDP-fucose transporter 1 isoform X1", "refseq_ac": "XP_005169110", "gene_names_uniprotkb": "slc35c1; fc03b12; wu:fc03b12; zgc:101867", "gene_names_refseq": "fc03b12; slc35c1; wu:fc03b12; zgc:101867", "protein_names_uniprotkb": "GDP-fucose transporter 1 isoform X1", "protein_names_refseq": "GDP-fucose transporter 1 isoform X1", "tax_id": 7955, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571); congenital disorder of glycosylation type IIc (Disease Ontology:DOID:0070255)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Putative transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0005457 GDP-fucose transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0036085 GDP-fucose import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH28-1", "uniprot_id": "A0A8M2BH28_DANRE", "mass": 37704.0, "length": 332, "protein_name": "Odorant receptor, family 42, subfamily A, member 4 isoform X1", "gene_name": "or42a4", "organism": "Zebrafish", "refseq_name": "odorant receptor, family 42, subfamily A, member 4 isoform X1", "refseq_ac": "XP_005169207", "gene_names_uniprotkb": "or42a4; Dr3OR10.23; OR109-8; or10.6; or109-11", "gene_names_refseq": "Dr3OR10.23; OR109-8; or10.6; or109-11; or42a4", "protein_names_uniprotkb": "Odorant receptor, family 42, subfamily A, member 4 isoform X1", "protein_names_refseq": "odorant receptor, family 42, subfamily A, member 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100148220)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15824306;16332259;20333175;26108469;32295537", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4IS60", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BH28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH68-1", "uniprot_id": "A0A8M2BH68_DANRE", "mass": 49053.0, "length": 443, "protein_name": "Homeobox-containing protein 1", "gene_name": "hmbox1a", "organism": "Zebrafish", "refseq_name": "homeobox-containing protein 1a isoform X1", "refseq_ac": "XP_005169888", "gene_names_uniprotkb": "hmbox1a; hmbox1; zgc:114064", "gene_names_refseq": "hmbox1a; hmbox1; zgc:114064", "protein_names_uniprotkb": "Homeobox-containing protein 1", "protein_names_refseq": "homeobox-containing protein 1a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0003691 double-stranded telomeric DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016605 PML body;GO:0015030 Cajal body;GO:0000781 chromosome, telomeric region;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0007004 telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH78-1", "uniprot_id": "A0A8M2BH78_DANRE", "mass": 112803.0, "length": 1009, "protein_name": "Synaptotagmin-like protein 1", "gene_name": "si:ch211-266g18.6", "organism": "Zebrafish", "refseq_name": "synaptotagmin-like protein 2 isoform X1", "refseq_ac": "XP_005169912", "gene_names_uniprotkb": "si:ch211-266g18.6", "gene_names_refseq": "si:ch211-266g18.6", "protein_names_uniprotkb": "Synaptotagmin-like protein 1; Exophilin-7", "protein_names_refseq": "synaptotagmin-like protein 2 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:565707)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070382 exocytic vesicle;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BH83-1", "uniprot_id": "A0A8M2BH83_DANRE", "mass": 111780.0, "length": 984, "protein_name": "Alpha-mannosidase", "gene_name": "man2b1", "organism": "Zebrafish", "refseq_name": "lysosomal alpha-mannosidase isoform X1", "refseq_ac": "XP_005169420", "gene_names_uniprotkb": "man2b1; zgc:110815", "gene_names_refseq": "man2b1; zgc:110815", "protein_names_uniprotkb": "Alpha-mannosidase; 3.2.1.-", "protein_names_refseq": "lysosomal alpha-mannosidase isoform X1", "tax_id": 7955, "disease": "alpha-mannosidosis (Disease Ontology:DOID:3413)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Can hydrolyze a variety of glycan substrates containing terminal alpha-mannosidic linkages. Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues on oligosaccharides generated by N-glycoprotein degradation pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BH83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHE6-1", "uniprot_id": "A0A8M2BHE6_DANRE", "mass": 34950.0, "length": 317, "protein_name": "Cyclin-dependent kinase 5 activator", "gene_name": "si:dkeyp-92c9.2", "organism": "Zebrafish", "refseq_name": "uncharacterized protein LOC571482", "refseq_ac": "NP_001038685", "gene_names_uniprotkb": "si:dkeyp-92c9.2", "gene_names_refseq": "si:dkeyp-92c9.2", "protein_names_uniprotkb": "Cyclin-dependent kinase 5 activator", "protein_names_refseq": "uncharacterized protein LOC571482", "tax_id": 7955, "disease": "lissencephaly (Disease Ontology:DOID:0050453); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dre:571482)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR32588729.15558462.1 [ECO:0000345] ##Evidence-Data-END## PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from JBMGRA010000019.1. On Sep 1, 2006 this sequence version replaced XP_700170.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LWT0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0012505 endomembrane system;GO:0016533 protein kinase 5 complex", "go_biological_process": "GO:0007420 brain development;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BHE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHH5-1", "uniprot_id": "A0A8M2BHH5_DANRE", "mass": 33070.0, "length": 307, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "si:ch73-359m17.2", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005170187", "gene_names_uniprotkb": "si:ch73-359m17.2", "gene_names_refseq": "si:ch73-359m17.2", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HZE2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0042806 fucose binding", "go_cellular_component": "", "go_biological_process": "GO:0001868 regulation of complement activation, lectin pathway;GO:0010185 regulation of cellular defense response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHN0-1", "uniprot_id": "A0A8M2BHN0_DANRE", "mass": 40021.0, "length": 365, "protein_name": "Transcriptional repressor protein YY1b isoform X1", "gene_name": "yy1b", "organism": "Zebrafish", "refseq_name": "transcriptional repressor protein YY1b isoform X1", "refseq_ac": "XP_005170286", "gene_names_uniprotkb": "yy1b; fb68e12; wu:fb68e12; yy1l; zgc:64207", "gene_names_refseq": "fb68e12; wu:fb68e12; yy1b; yy1l; zgc:64207", "protein_names_uniprotkb": "Transcriptional repressor protein YY1b isoform X1", "protein_names_refseq": "transcriptional repressor protein YY1b isoform X1", "tax_id": 7955, "disease": "pleuropulmonary blastoma (Disease Ontology:DOID:4769); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0070328 triglyceride homeostasis;GO:0046890 regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHN3-1", "uniprot_id": "A0A8M2BHN3_DANRE", "mass": 28841.0, "length": 270, "protein_name": "Claudin-2", "gene_name": "cldn2", "organism": "Zebrafish", "refseq_name": "claudin-2", "refseq_ac": "NP_001004559", "gene_names_uniprotkb": "cldn2; zgc:92260", "gene_names_refseq": "cldn2; zgc:92260", "protein_names_uniprotkb": "Claudin-2", "protein_names_refseq": "claudin-2", "tax_id": 7955, "disease": "autosomal recessive nonsyndromic deafness 29 (Disease Ontology:DOID:0110487)", "pathway": " (dre:562525)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20553723;21600298;23726886;25460834;26469318;28598490;29651289;32411141;37142828;37778980", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC081634.1, CF998858.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000021.1. On or before Aug 5, 2009 this sequence version replaced XP_690993.2, NP_001004559.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1QKA9", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M2BHN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHT5-1", "uniprot_id": "A0A8M2BHT5_DANRE", "mass": 47918.0, "length": 419, "protein_name": "Hyaluronan and proteoglycan link protein 4", "gene_name": "hapln4", "organism": "Zebrafish", "refseq_name": "hyaluronan and proteoglycan link protein 4 isoform X1", "refseq_ac": "XP_005170516", "gene_names_uniprotkb": "hapln4; si:dkey-19f23.2", "gene_names_refseq": "hapln4; si:dkey-19f23.2", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 4; Brain link protein 2", "protein_names_refseq": "hyaluronan and proteoglycan link protein 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559818)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15520368;27189481;28252024;30929901;34543380", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs. Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BHT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHV4-1", "uniprot_id": "A0A8M2BHV4_DANRE", "mass": 36354.0, "length": 329, "protein_name": "Uncharacterized protein si:dkey-172o19.2", "gene_name": "si:dkey-172o19.2", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:dkey-172o19.2", "refseq_ac": "XP_005170589", "gene_names_uniprotkb": "si:dkey-172o19.2", "gene_names_refseq": "si:dkey-172o19.2", "protein_names_uniprotkb": "Uncharacterized protein si:dkey-172o19.2", "protein_names_refseq": "uncharacterized protein si:dkey-172o19.2", "tax_id": 7955, "disease": "", "pathway": " (dre:100000812)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005170589.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHZ7-1", "uniprot_id": "A0A8M2BHZ7_DANRE", "mass": 26941.0, "length": 239, "protein_name": "Inhibitory synaptic factor 1", "gene_name": "LOC101884359", "organism": "Zebrafish", "refseq_name": "inhibitory synaptic factor 1", "refseq_ac": "XP_005170775", "gene_names_uniprotkb": "LOC101884359", "gene_names_refseq": "LOC101884359", "protein_names_uniprotkb": "Inhibitory synaptic factor 1", "protein_names_refseq": "inhibitory synaptic factor 1", "tax_id": 7955, "disease": "", "pathway": " (dre:101884359)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0014069 postsynaptic density", "go_biological_process": "GO:0060080 inhibitory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BHZ9-1", "uniprot_id": "A0A8M2BHZ9_DANRE", "mass": 27077.0, "length": 234, "protein_name": "Artemin isoform X1", "gene_name": "artna", "organism": "Zebrafish", "refseq_name": "artemin isoform X1", "refseq_ac": "XP_005170818", "gene_names_uniprotkb": "artna; artn", "gene_names_refseq": "artn", "protein_names_uniprotkb": "Artemin isoform X1", "protein_names_refseq": "artemin isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101882107)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XP_005170818.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BHZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BI23-1", "uniprot_id": "A0A8M2BI23_DANRE", "mass": 31333.0, "length": 274, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC101885342", "organism": "Zebrafish", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC101885342", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 7955, "disease": "", "pathway": " (dre:101885342)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BI23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BI85-1", "uniprot_id": "A0A8M2BI85_DANRE", "mass": 41973.0, "length": 373, "protein_name": "Arfaptin-1 isoform X5", "gene_name": "arfip1", "organism": "Zebrafish", "refseq_name": "arfaptin-1 isoform X5", "refseq_ac": "XP_005170950", "gene_names_uniprotkb": "arfip1; id:ibd2077; wu:fd18g10; zgc:66341", "gene_names_refseq": "arfip1; id:ibd2077; wu:fd18g10; zgc:66341", "protein_names_uniprotkb": "Arfaptin-1 isoform X5", "protein_names_refseq": "arfaptin-1 isoform X5", "tax_id": 7955, "disease": "", "pathway": " (dre:100003895)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11731487;17251491;27189481;33164759;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H2E6", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019904 protein domain specific binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A8M2BI85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BI41-1", "uniprot_id": "A0A8M2BI41_DANRE", "mass": 82687.0, "length": 751, "protein_name": "Post-GPI attachment to proteins factor 6 isoform X1", "gene_name": "pgap6", "organism": "Zebrafish", "refseq_name": "post-GPI attachment to proteins factor 6 isoform X1", "refseq_ac": "XP_005170920", "gene_names_uniprotkb": "pgap6; si:dkeyp-75b4.6; tmem8a", "gene_names_refseq": "pgap6; si:dkeyp-75b4.6; tmem8a", "protein_names_uniprotkb": "Post-GPI attachment to proteins factor 6 isoform X1", "protein_names_refseq": "post-GPI attachment to proteins factor 6 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:559126)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25078621;26469318", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BI41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BI52-1", "uniprot_id": "A0A8M2BI52_DANRE", "mass": 72090.0, "length": 649, "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1", "gene_name": "eps8l1b", "organism": "Zebrafish", "refseq_name": "epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1", "refseq_ac": "XP_005170855", "gene_names_uniprotkb": "eps8l1b", "gene_names_refseq": "eps8l1b", "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1", "protein_names_refseq": "epidermal growth factor receptor kinase substrate 8-like protein 1 isoform X1", "tax_id": 7955, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dre:553062)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58ISL3", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BI52-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BI86-1", "uniprot_id": "A0A8M2BI86_DANRE", "mass": 58790.0, "length": 541, "protein_name": "Transmembrane protease serine 3", "gene_name": "tmprss3b", "organism": "Zebrafish", "refseq_name": "transmembrane protease serine 3", "refseq_ac": "XP_005171071", "gene_names_uniprotkb": "tmprss3b", "gene_names_refseq": "tmprss3b", "protein_names_uniprotkb": "Transmembrane protease serine 3", "protein_names_refseq": "transmembrane protease serine 3", "tax_id": 7955, "disease": "", "pathway": " (dre:101885235)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005171071.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BI86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIB3-1", "uniprot_id": "A0A8M2BIB3_DANRE", "mass": 37093.0, "length": 332, "protein_name": "Kininogen-1 isoform X1", "gene_name": "kng1", "organism": "Zebrafish", "refseq_name": "kininogen-1 isoform X1", "refseq_ac": "XP_005170607", "gene_names_uniprotkb": "kng1; fb64g01; wu:fb64g01; zgc:103569", "gene_names_refseq": "fb64g01; kng1; wu:fb64g01; zgc:103569", "protein_names_uniprotkb": "Kininogen-1 isoform X1", "protein_names_refseq": "kininogen-1 isoform X1", "tax_id": 7955, "disease": "stroke (Disease Ontology:DOID:0051061); high molecular weight kininogen deficiency (Disease Ontology:DOID:0111676); IgA vasculitis (Disease Ontology:DOID:11123); hereditary angioedema (Disease Ontology:DOID:14735); abdominal aortic aneurysm (Disease Ontology:DOID:7693); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005170607.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0007162 negative regulation of cell adhesion;GO:0030195 negative regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIB9-1", "uniprot_id": "A0A8M2BIB9_DANRE", "mass": 84889.0, "length": 761, "protein_name": "Adhesion G protein-coupled receptor E5 isoform X1", "gene_name": "adgre5b.1", "organism": "Zebrafish", "refseq_name": "adhesion G protein-coupled receptor E5 isoform X1", "refseq_ac": "XP_005171094", "gene_names_uniprotkb": "adgre5b.1", "gene_names_refseq": "adgre5b.1", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor E5 isoform X1", "protein_names_refseq": "adhesion G protein-coupled receptor E5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100536657)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIE5-1", "uniprot_id": "A0A8M2BIE5_DANRE", "mass": 30451.0, "length": 270, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "mul3", "organism": "Zebrafish", "refseq_name": "mitochondrial ubiquitin ligase activator of nfkb 1-A", "refseq_ac": "XP_005171182", "gene_names_uniprotkb": "mul3", "gene_names_refseq": "mul3", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "mitochondrial ubiquitin ligase activator of nfkb 1-A", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dre:402879)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q6C7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0016567 protein ubiquitination;GO:0090141 positive regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIF1-1", "uniprot_id": "A0A8M2BIF1_DANRE", "mass": 63739.0, "length": 566, "protein_name": "BCL6A transcription repressor b isoform X1", "gene_name": "bcl6ab", "organism": "Zebrafish", "refseq_name": "BCL6A transcription repressor b isoform X1", "refseq_ac": "XP_005171194", "gene_names_uniprotkb": "bcl6ab; fj23a05; wu:fj23a05; wu:fv66b06", "gene_names_refseq": "bcl6ab; fj23a05; wu:fj23a05; wu:fv66b06", "protein_names_uniprotkb": "BCL6A transcription repressor b isoform X1", "protein_names_refseq": "BCL6A transcription repressor b isoform X1", "tax_id": 7955, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (dre:100001936)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19439512;24023910;25556858;26469318;29257949", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BIF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIG8-1", "uniprot_id": "A0A8M2BIG8_DANRE", "mass": 49459.0, "length": 461, "protein_name": "Golgi reassembly-stacking protein 1a isoform X1", "gene_name": "gorasp1a", "organism": "Zebrafish", "refseq_name": "Golgi reassembly-stacking protein 1a isoform X1", "refseq_ac": "XP_005171287", "gene_names_uniprotkb": "gorasp1a; cb744; gorasp1; zgc:101588", "gene_names_refseq": "cb744; gorasp1a; gorasp1; zgc:101588", "protein_names_uniprotkb": "Golgi reassembly-stacking protein 1a isoform X1", "protein_names_refseq": "Golgi reassembly-stacking protein 1a isoform X1", "tax_id": 7955, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIQ8-1", "uniprot_id": "A0A8M2BIQ8_DANRE", "mass": 102756.0, "length": 922, "protein_name": "Extended synaptotagmin-2-A isoform X1", "gene_name": "esyt2a", "organism": "Zebrafish", "refseq_name": "extended synaptotagmin-2-A isoform X1", "refseq_ac": "XP_005171454", "gene_names_uniprotkb": "esyt2a", "gene_names_refseq": "esyt2a", "protein_names_uniprotkb": "Extended synaptotagmin-2-A isoform X1", "protein_names_refseq": "extended synaptotagmin-2-A isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570012)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005171454.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIT2-1", "uniprot_id": "A0A8M2BIT2_DANRE", "mass": 64630.0, "length": 590, "protein_name": "Glypican-5 isoform X1", "gene_name": "gpc5c", "organism": "Zebrafish", "refseq_name": "glypican-5 isoform X1", "refseq_ac": "XP_005171487", "gene_names_uniprotkb": "gpc5c", "gene_names_refseq": "gpc5c", "protein_names_uniprotkb": "Glypican-5 isoform X1", "protein_names_refseq": "glypican-5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100006305)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005171487.2. COMPLETENESS: full length., [RefSeq]; Cell surface proteoglycan., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0098552 side of membrane;GO:0009986 cell surface", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0016477 cell migration;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1905475 regulation of protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIW5-1", "uniprot_id": "A0A8M2BIW5_DANRE", "mass": 77752.0, "length": 692, "protein_name": "Uncharacterized protein si:dkeyp-68b7.7 isoform X1", "gene_name": "si:dkeyp-68b7.7", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:dkeyp-68b7.7 isoform X1", "refseq_ac": "XP_005171531", "gene_names_uniprotkb": "si:dkeyp-68b7.7", "gene_names_refseq": "si:dkeyp-68b7.7", "protein_names_uniprotkb": "Uncharacterized protein si:dkeyp-68b7.7 isoform X1", "protein_names_refseq": "uncharacterized protein si:dkeyp-68b7.7 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:566190)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005171531.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BIX1-1", "uniprot_id": "A0A8M2BIX1_DANRE", "mass": 59745.0, "length": 541, "protein_name": "Interleukin-2 receptor subunit beta isoform X1", "gene_name": "il2rb", "organism": "Zebrafish", "refseq_name": "interleukin-2 receptor subunit beta isoform X1", "refseq_ac": "XP_005171649", "gene_names_uniprotkb": "il2rb; il-2rb", "gene_names_refseq": "il-2rb; il2rb", "protein_names_uniprotkb": "Interleukin-2 receptor subunit beta isoform X1", "protein_names_refseq": "interleukin-2 receptor subunit beta isoform X1", "tax_id": 7955, "disease": "COVID-19 (Disease Ontology:DOID:0080600); immunodeficiency 63 (Disease Ontology:DOID:0111997); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); myasthenia gravis (Disease Ontology:DOID:437); visceral leishmaniasis (Disease Ontology:DOID:9146)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0019221 cytokine-mediated signaling pathway;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BIX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ06-1", "uniprot_id": "A0A8M2BJ06_DANRE", "mass": 45266.0, "length": 392, "protein_name": "Nucleosome assembly protein 1-like 1 isoform X1", "gene_name": "nap1l1", "organism": "Zebrafish", "refseq_name": "nucleosome assembly protein 1-like 1 isoform X1", "refseq_ac": "XP_005171724", "gene_names_uniprotkb": "nap1l1; cb716; sb:cb13; wu:fb83g07", "gene_names_refseq": "cb716; nap1l1; sb:cb13; wu:fb83g07", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 1 isoform X1", "protein_names_refseq": "nucleosome assembly protein 1-like 1 isoform X1", "tax_id": 7955, "disease": "appendiceal neoplasm (Disease Ontology:DOID:11240); pancreatic cancer (Disease Ontology:DOID:1793); hepatoblastoma (Disease Ontology:DOID:687)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001878 response to yeast;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ21-1", "uniprot_id": "A0A8M2BJ21_DANRE", "mass": 47563.0, "length": 408, "protein_name": "Carnosine N-methyltransferase", "gene_name": "carnmt1", "organism": "Zebrafish", "refseq_name": "carnosine N-methyltransferase isoform X1", "refseq_ac": "XP_005171825", "gene_names_uniprotkb": "carnmt1; wu:fj43d04; zgc:112985", "gene_names_refseq": "carnmt1; wu:fj43d04; zgc:112985", "protein_names_uniprotkb": "Carnosine N-methyltransferase; 2.1.1.22", "protein_names_refseq": "carnosine N-methyltransferase isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030735 carnosine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0035498 carnosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ38-1", "uniprot_id": "A0A8M2BJ38_DANRE", "mass": 23351.0, "length": 214, "protein_name": "AN1-type zinc finger protein 5a isoform X1", "gene_name": "zfand5a", "organism": "Zebrafish", "refseq_name": "AN1-type zinc finger protein 5a isoform X1", "refseq_ac": "XP_005171883", "gene_names_uniprotkb": "zfand5a; id:ibd2892; wu:fb16d02; wu:fc67h07; za20d2; zgc:73363", "gene_names_refseq": "id:ibd2892; wu:fb16d02; wu:fc67h07; za20d2; zfand5a; zgc:73363", "protein_names_uniprotkb": "AN1-type zinc finger protein 5a isoform X1", "protein_names_refseq": "AN1-type zinc finger protein 5a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:406312)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JI82;A2BFW0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ62-1", "uniprot_id": "A0A8M2BJ62_DANRE", "mass": 30495.0, "length": 274, "protein_name": "Transport and Golgi organization protein 2 homolog isoform X1", "gene_name": "tango2", "organism": "Zebrafish", "refseq_name": "transport and Golgi organization protein 2 homolog isoform X1", "refseq_ac": "XP_005171895", "gene_names_uniprotkb": "tango2; wu:fj48d05; zgc:100952", "gene_names_refseq": "tango2; wu:fj48d05; zgc:100952", "protein_names_uniprotkb": "Transport and Golgi organization protein 2 homolog isoform X1", "protein_names_refseq": "transport and Golgi organization protein 2 homolog isoform X1", "tax_id": 7955, "disease": "TANGO2-related metabolic encephalopathy and arrythmias (Disease Ontology:DOID:0081386)", "pathway": " (dre:445324)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8RVG3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0019216 regulation of lipid metabolic process;GO:0060047 heart contraction;GO:0048741 skeletal muscle fiber development;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ69-1", "uniprot_id": "A0A8M2BJ69_DANRE", "mass": 122548.0, "length": 1108, "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "vcpip1", "organism": "Zebrafish", "refseq_name": "deubiquitinating protein VCPIP1", "refseq_ac": "XP_005171450", "gene_names_uniprotkb": "vcpip1", "gene_names_refseq": "vcpip1", "protein_names_uniprotkb": "Deubiquitinating protein VCPIP1; 3.4.19.12; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135", "protein_names_refseq": "deubiquitinating protein VCPIP1", "tax_id": 7955, "disease": "progeria (Disease Ontology:DOID:3911)", "pathway": " (R-DRE-5689896)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HSN4;F1REJ4", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006508 proteolysis;GO:0016567 protein ubiquitination;GO:0090168 Golgi reassembly;GO:0016320 endoplasmic reticulum membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ77-1", "uniprot_id": "A0A8M2BJ77_DANRE", "mass": 55566.0, "length": 497, "protein_name": "calcium/calmodulin-dependent protein kinase", "gene_name": "camkk1a", "organism": "Zebrafish", "refseq_name": "calcium/calmodulin-dependent protein kinase kinase 1 isoform X1", "refseq_ac": "XP_005171905", "gene_names_uniprotkb": "camkk1a; camkk1; zgc:113440", "gene_names_refseq": "camkk1a; camkk1; zgc:113440", "protein_names_uniprotkb": "calcium/calmodulin-dependent protein kinase; 2.7.11.17", "protein_names_refseq": "calcium/calmodulin-dependent protein kinase kinase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58JIX8;A0AC58JIZ0;A0AC58JIZ1", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0061762 CAMKK-AMPK signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ83-1", "uniprot_id": "A0A8M2BJ83_DANRE", "mass": 28363.0, "length": 254, "protein_name": "MAP6 domain-containing protein 1 isoform X1", "gene_name": "map6d1", "organism": "Zebrafish", "refseq_name": "MAP6 domain-containing protein 1 isoform X1", "refseq_ac": "XP_005171477", "gene_names_uniprotkb": "map6d1", "gene_names_refseq": "map6d1", "protein_names_uniprotkb": "MAP6 domain-containing protein 1 isoform X1", "protein_names_refseq": "MAP6 domain-containing protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101885657)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005171477.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005798 Golgi-associated vesicle;GO:0005874 microtubule;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0030705 cytoskeleton-dependent intracellular transport;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJ83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJ97-1", "uniprot_id": "A0A8M2BJ97_DANRE", "mass": 128357.0, "length": 1170, "protein_name": "KN motif and ankyrin repeat domain-containing protein 1b isoform X1", "gene_name": "kank1b", "organism": "Zebrafish", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 1b isoform X1", "refseq_ac": "XP_005171947", "gene_names_uniprotkb": "kank1b; si:dkey-226m8.9", "gene_names_refseq": "kank1b; si:dkey-226m8.9", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 1b isoform X1", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 1b isoform X1", "tax_id": 7955, "disease": "spastic quadriplegic cerebral palsy 2 (Disease Ontology:DOID:0081360); cancer (Disease Ontology:DOID:162); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dre:561164)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22387208;26469318;27189481;27292017;28067315", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BJ97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJD9-1", "uniprot_id": "A0A8M2BJD9_DANRE", "mass": 43766.0, "length": 399, "protein_name": "POU domain protein", "gene_name": "pou2f3", "organism": "Zebrafish", "refseq_name": "POU domain, class 2, transcription factor 3 isoform X1", "refseq_ac": "XP_005172050", "gene_names_uniprotkb": "pou2f3; zgc:136377; zgc:158534", "gene_names_refseq": "pou2f3; zgc:136377; zgc:158534", "protein_names_uniprotkb": "POU domain protein", "protein_names_refseq": "POU domain, class 2, transcription factor 3 isoform X1", "tax_id": 7955, "disease": "immune system disease (Disease Ontology:DOID:2914)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "26469318;27189481", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8M2BJD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJE7-1", "uniprot_id": "A0A8M2BJE7_DANRE", "mass": 37569.0, "length": 339, "protein_name": "Urotensin-2 receptor", "gene_name": "uts2r4", "organism": "Zebrafish", "refseq_name": "urotensin-2 receptor", "refseq_ac": "XP_005172122", "gene_names_uniprotkb": "uts2r4", "gene_names_refseq": "uts2r4", "protein_names_uniprotkb": "Urotensin-2 receptor; Urotensin II receptor", "protein_names_refseq": "urotensin-2 receptor", "tax_id": 7955, "disease": "", "pathway": " (dre:100334958)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133181) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005172122.2. COMPLETENESS: full length., [RefSeq]; G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B. Upon ligand binding, activates intracellular signaling cascades via G-protein coupling, primarily through Gq/11, leading to phospholipase C activation, increased intracellular calcium, and activation of protein kinase C (PKC). Through coupling to G(i)/G(o) alpha subunits, stimulates MAPK/ERK pathways and thereby contributes to regulation of vascular tone, cardiac contractility, and cell proliferation. Ligand binding also triggers a marked reduction in the biogenesis of autophagosomes by inhibiting the recruitment of ATG16L1 to pre-autophagosomal endocytic vesicles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001604 urotensin II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008217 regulation of blood pressure;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJN9-1", "uniprot_id": "A0A8M2BJN9_DANRE", "mass": 103569.0, "length": 944, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 33", "gene_name": "adam19a", "organism": "Zebrafish", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 33", "refseq_ac": "XP_005172418", "gene_names_uniprotkb": "adam19a", "gene_names_refseq": "adam19a", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 33", "protein_names_refseq": "disintegrin and metalloproteinase domain-containing protein 33", "tax_id": 7955, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (dre:565342)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133182) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BJN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJS4-1", "uniprot_id": "A0A8M2BJS4_DANRE", "mass": 105376.0, "length": 922, "protein_name": "Oxysterol-binding protein", "gene_name": "osbpl6", "organism": "Zebrafish", "refseq_name": "oxysterol-binding protein-related protein 6 isoform 2", "refseq_ac": "NP_001429235", "gene_names_uniprotkb": "osbpl6; si:ch211-222f23.4", "gene_names_refseq": "osbpl6; si:ch211-222f23.4", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "oxysterol-binding protein-related protein 6 isoform 2", "tax_id": 7955, "disease": "", "pathway": " (dre:100004342)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17950734;18803835;24326072;26469318;27189481", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01029203.1, SRR32588735.3560532.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000009.1. On Jul 31, 2025 this sequence version replaced XP_005172564.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120015 sterol transfer activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BJS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BJW7-1", "uniprot_id": "A0A8M2BJW7_DANRE", "mass": 44063.0, "length": 402, "protein_name": "Uncharacterized protein isoform X1", "gene_name": "hhla2a.1", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005172726", "gene_names_uniprotkb": "hhla2a.1; zgc:113255", "gene_names_refseq": "hhla2a.1; zgc:113255", "protein_names_uniprotkb": "Uncharacterized protein isoform X1", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0031295 T cell costimulation;GO:0042130 negative regulation of T cell proliferation;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BJW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BK08-1", "uniprot_id": "A0A8M2BK08_DANRE", "mass": 147013.0, "length": 1356, "protein_name": "Adhesion G-protein coupled receptor G2", "gene_name": "LOC101883602", "organism": "Zebrafish", "refseq_name": "uncharacterized protein isoform X1", "refseq_ac": "XP_005172793", "gene_names_uniprotkb": "LOC101883602", "gene_names_refseq": "LOC101883602", "protein_names_uniprotkb": "Adhesion G-protein coupled receptor G2; G-protein coupled receptor 64", "protein_names_refseq": "uncharacterized protein isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101883602)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133185) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BK08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BK34-1", "uniprot_id": "A0A8M2BK34_DANRE", "mass": 20647.0, "length": 196, "protein_name": "SOSS complex subunit B2", "gene_name": "nabp2", "organism": "Zebrafish", "refseq_name": "SOSS complex subunit B2", "refseq_ac": "XP_005172861", "gene_names_uniprotkb": "nabp2", "gene_names_refseq": "nabp2", "protein_names_uniprotkb": "SOSS complex subunit B2", "protein_names_refseq": "SOSS complex subunit B2", "tax_id": 7955, "disease": "", "pathway": " (dre:101882738); (R-DRE-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133186) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7F5S2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005694 chromosome;GO:0070876 SOSS complex", "go_biological_process": "GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BK34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BK99-1", "uniprot_id": "A0A8M2BK99_DANRE", "mass": 41945.0, "length": 377, "protein_name": "E3 ubiquitin-protein ligase RNF34a isoform X1", "gene_name": "rnf34a", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF34a isoform X1", "refseq_ac": "XP_005172521", "gene_names_uniprotkb": "rnf34a; fi35g06; wu:fi35g06; zgc:114043", "gene_names_refseq": "fi35g06; rnf34a; wu:fi35g06; zgc:114043", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF34a isoform X1", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF34a isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133183) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BK99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKC1-1", "uniprot_id": "A0A8M2BKC1_DANRE", "mass": 34153.0, "length": 293, "protein_name": "Sulfotransferase", "gene_name": "hs3st1", "organism": "Zebrafish", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 1 isoform X1", "refseq_ac": "XP_005173108", "gene_names_uniprotkb": "hs3st1", "gene_names_refseq": "hs3st1", "protein_names_uniprotkb": "Sulfotransferase; 2.8.2.-", "protein_names_refseq": "heparan sulfate glucosamine 3-O-sulfotransferase 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58H6I2;A0AC58H6K4", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity", "go_cellular_component": "GO:0005796 Golgi lumen", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKD5-1", "uniprot_id": "A0A8M2BKD5_DANRE", "mass": 54044.0, "length": 485, "protein_name": "Ras GTPase-activating protein-binding protein 1 isoform X1", "gene_name": "g3bp1", "organism": "Zebrafish", "refseq_name": "ras GTPase-activating protein-binding protein 1 isoform X1", "refseq_ac": "XP_005173159", "gene_names_uniprotkb": "g3bp1; fj17h05; wu:fj17h05; zgc:56034", "gene_names_refseq": "fj17h05; g3bp1; wu:fj17h05; zgc:56034", "protein_names_uniprotkb": "Ras GTPase-activating protein-binding protein 1 isoform X1", "protein_names_refseq": "ras GTPase-activating protein-binding protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0003678 DNA helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045087 innate immune response;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M2BKD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKN8-1", "uniprot_id": "A0A8M2BKN8_DANRE", "mass": 54875.0, "length": 481, "protein_name": "E3 ubiquitin-protein ligase RNF14", "gene_name": "loc558876", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF14-like isoform X1", "refseq_ac": "XP_005173426", "gene_names_uniprotkb": "loc558876; LOC558876", "gene_names_refseq": "LOC558876", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF14; 2.3.2.31; RING finger protein 14", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF14-like isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:558876)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_005173426.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKN9-1", "uniprot_id": "A0A8M2BKN9_DANRE", "mass": 46508.0, "length": 413, "protein_name": "E3 ubiquitin-protein ligase RNF14", "gene_name": "zmp:0000000524", "organism": "Zebrafish", "refseq_name": "E3 ubiquitin-protein ligase RNF14-like", "refseq_ac": "XP_005173423", "gene_names_uniprotkb": "zmp:0000000524", "gene_names_refseq": "zmp:0000000524", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF14; 2.3.2.31; RING finger protein 14", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF14-like", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HEP9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKR3-1", "uniprot_id": "A0A8M2BKR3_DANRE", "mass": 39853.0, "length": 352, "protein_name": "C-C chemokine receptor type 8", "gene_name": "si:cabz01093077.1", "organism": "Zebrafish", "refseq_name": "C-C chemokine receptor type 8", "refseq_ac": "XP_005173521", "gene_names_uniprotkb": "si:cabz01093077.1", "gene_names_refseq": "si:cabz01093077.1", "protein_names_uniprotkb": "C-C chemokine receptor type 8", "protein_names_refseq": "C-C chemokine receptor type 8", "tax_id": 7955, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Alzheimer's disease (Disease Ontology:DOID:10652); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Lewy body dementia (Disease Ontology:DOID:12217); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); hepatitis B (Disease Ontology:DOID:2043); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); liver cirrhosis (Disease Ontology:DOID:5082); rheumatoid arthritis (Disease Ontology:DOID:7148); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ulcerative colitis (Disease Ontology:DOID:8577); systemic lupus erythematosus (Disease Ontology:DOID:9074); visceral leishmaniasis (Disease Ontology:DOID:9146); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100329837)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005173521.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKS4-1", "uniprot_id": "A0A8M2BKS4_DANRE", "mass": 43051.0, "length": 380, "protein_name": "C-X-C chemokine receptor type 3.3 isoform X1", "gene_name": "cxcr3.3", "organism": "Zebrafish", "refseq_name": "C-X-C chemokine receptor type 3.3 isoform X1", "refseq_ac": "XP_005173552", "gene_names_uniprotkb": "cxcr3.3; si:dkey-269d20.3", "gene_names_refseq": "cxcr3.3; si:dkey-269d20.3", "protein_names_uniprotkb": "C-X-C chemokine receptor type 3.3 isoform X1", "protein_names_refseq": "C-X-C chemokine receptor type 3.3 isoform X1", "tax_id": 7955, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); dilated cardiomyopathy (Disease Ontology:DOID:12930); pulmonary sarcoidosis (Disease Ontology:DOID:13406); thoracic aortic aneurysm (Disease Ontology:DOID:14004); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); coronary restenosis (Disease Ontology:DOID:4247); myasthenia gravis (Disease Ontology:DOID:437); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ulcerative colitis (Disease Ontology:DOID:8577); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dre:799527)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25573892;26083432;26469318;28440030;31529512", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_005173552.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BKS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKW4-1", "uniprot_id": "A0A8M2BKW4_DANRE", "mass": 46240.0, "length": 427, "protein_name": "Probable proton-coupled zinc antiporter SLC30A4", "gene_name": "slc30a4", "organism": "Zebrafish", "refseq_name": "probable proton-coupled zinc antiporter SLC30A4 isoform X1", "refseq_ac": "XP_005173674", "gene_names_uniprotkb": "slc30a4; zgc:64215", "gene_names_refseq": "slc30a4; zgc:64215", "protein_names_uniprotkb": "Probable proton-coupled zinc antiporter SLC30A4; Solute carrier family 30 member 4; Zinc transporter 4", "protein_names_refseq": "probable proton-coupled zinc antiporter SLC30A4 isoform X1", "tax_id": 7955, "disease": "prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment. Controls zinc deposition in milk., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HSW7;A0AC58HT05", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLA4-1", "uniprot_id": "A0A8M2BLA4_DANRE", "mass": 82119.0, "length": 725, "protein_name": "RAS guanyl-releasing protein 4 isoform X1", "gene_name": "rasgrp4", "organism": "Zebrafish", "refseq_name": "RAS guanyl-releasing protein 4 isoform X1", "refseq_ac": "XP_005173714", "gene_names_uniprotkb": "rasgrp4; si:dkey-12o15.1", "gene_names_refseq": "rasgrp4; si:dkey-12o15.1", "protein_names_uniprotkb": "RAS guanyl-releasing protein 4 isoform X1", "protein_names_refseq": "RAS guanyl-releasing protein 4 isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0001945 lymph vessel development;GO:0002717 positive regulation of natural killer cell mediated immunity;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BKX6-1", "uniprot_id": "A0A8M2BKX6_DANRE", "mass": 188715.0, "length": 1718, "protein_name": "Signal-induced proliferation-associated 1-like protein 3 isoform X1", "gene_name": "sipa1l3", "organism": "Zebrafish", "refseq_name": "signal-induced proliferation-associated 1-like protein 3 isoform X1", "refseq_ac": "XP_005173729", "gene_names_uniprotkb": "sipa1l3", "gene_names_refseq": "sipa1l3", "protein_names_uniprotkb": "Signal-induced proliferation-associated 1-like protein 3 isoform X1", "protein_names_refseq": "signal-induced proliferation-associated 1-like protein 3 isoform X1", "tax_id": 7955, "disease": "cataract 45 (Disease Ontology:DOID:0110262); cataract (Disease Ontology:DOID:83)", "pathway": " (dre:561005)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8RNK4", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0003382 epithelial cell morphogenesis;GO:0090162 establishment of epithelial cell polarity;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BKX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BL42-1", "uniprot_id": "A0A8M2BL42_DANRE", "mass": 41556.0, "length": 357, "protein_name": "Progestin and adipoQ receptor family member VII, a", "gene_name": "paqr7a", "organism": "Zebrafish", "refseq_name": "progestin and adipoQ receptor family member VII, a", "refseq_ac": "NP_001093530", "gene_names_uniprotkb": "paqr7a; si:dkey-194c21.2", "gene_names_refseq": "mpra1; paqr7a; si:dkey-194c21.2", "protein_names_uniprotkb": "Progestin and adipoQ receptor family member VII, a", "protein_names_refseq": "progestin and adipoQ receptor family member VII, a", "tax_id": 7955, "disease": "", "pathway": " (dre:798104)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "26108469;31301284;31536721;32387526;35139421", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: GFIL01029470.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000019.1. On Jul 26, 2007 this sequence version replaced XP_001338559.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4I9I9", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003707 nuclear steroid receptor activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0048545 response to steroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M2BL42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BL77-1", "uniprot_id": "A0A8M2BL77_DANRE", "mass": 23568.0, "length": 212, "protein_name": "Steroid receptor RNA activator 1", "gene_name": "sra1", "organism": "Zebrafish", "refseq_name": "steroid receptor RNA activator 1 isoform X1", "refseq_ac": "XP_005173954", "gene_names_uniprotkb": "sra1; zgc:86613", "gene_names_refseq": "sra1; zgc:86613", "protein_names_uniprotkb": "Steroid receptor RNA activator 1; Steroid receptor RNA activator protein", "protein_names_refseq": "steroid receptor RNA activator 1 isoform X1", "tax_id": 7955, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BL77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLA7-1", "uniprot_id": "A0A8M2BLA7_DANRE", "mass": 80822.0, "length": 717, "protein_name": "Calpain-12 isoform X1", "gene_name": "capn12", "organism": "Zebrafish", "refseq_name": "calpain-12 isoform X1", "refseq_ac": "XP_005173727", "gene_names_uniprotkb": "capn12; si:ch211-160d20.1", "gene_names_refseq": "capn12; si:ch211-160d20.1", "protein_names_uniprotkb": "Calpain-12 isoform X1", "protein_names_refseq": "calpain-12 isoform X1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dre:799247)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "26110643;27189481;27769845;28096348;30588557;30944473;33435938;36077499", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M2BLA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLB3-1", "uniprot_id": "A0A8M2BLB3_DANRE", "mass": 160761.0, "length": 1455, "protein_name": "Helicase ARIP4 isoform X1", "gene_name": "rad54l2", "organism": "Zebrafish", "refseq_name": "helicase ARIP4 isoform X1", "refseq_ac": "XP_005174062", "gene_names_uniprotkb": "rad54l2", "gene_names_refseq": "rad54l2", "protein_names_uniprotkb": "Helicase ARIP4 isoform X1", "protein_names_refseq": "helicase ARIP4 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:558947)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003712 transcription coregulator activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLC4-1", "uniprot_id": "A0A8M2BLC4_DANRE", "mass": 80606.0, "length": 704, "protein_name": "Calpain-1 catalytic subunit", "gene_name": "capn1b", "organism": "Zebrafish", "refseq_name": "calpain-1 catalytic subunit b isoform X1", "refseq_ac": "XP_068072443", "gene_names_uniprotkb": "capn1b; si:ch211-203k12.4; si:dkeyp-101g1.3", "gene_names_refseq": "capn1b; si:ch211-203k12.4; si:dkeyp-101g1.3", "protein_names_uniprotkb": "Calpain-1 catalytic subunit; 3.4.22.52; Calpain-1 large subunit", "protein_names_refseq": "calpain-1 catalytic subunit b isoform X1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:565106)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18265014;23357851;26908177;27153400;28252024;30029251;30944473;33168193;34400286", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0A8M2BLC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLD7-1", "uniprot_id": "A0A8M2BLD7_DANRE", "mass": 51964.0, "length": 452, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC101885029", "organism": "Zebrafish", "refseq_name": "NUAK family SNF1-like kinase 1", "refseq_ac": "XP_005174173", "gene_names_uniprotkb": "LOC101885029", "gene_names_refseq": "LOC101885029", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "NUAK family SNF1-like kinase 1", "tax_id": 7955, "disease": "", "pathway": " (dre:101885029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLF3-1", "uniprot_id": "A0A8M2BLF3_DANRE", "mass": 103817.0, "length": 933, "protein_name": "N-acetyltransferase ESCO1 isoform X1", "gene_name": "esco1", "organism": "Zebrafish", "refseq_name": "N-acetyltransferase ESCO1 isoform X1", "refseq_ac": "XP_005174247", "gene_names_uniprotkb": "esco1", "gene_names_refseq": "esco1", "protein_names_uniprotkb": "N-acetyltransferase ESCO1 isoform X1", "protein_names_refseq": "N-acetyltransferase ESCO1 isoform X1", "tax_id": 7955, "disease": "Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": " (dre:100333282)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.3.1.-;2.3.1.259;2.3.1.57", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLF5-1", "uniprot_id": "A0A8M2BLF5_DANRE", "mass": 125919.0, "length": 1153, "protein_name": "Calpain-15 isoform X1", "gene_name": "capn15", "organism": "Zebrafish", "refseq_name": "calpain-15 isoform X1", "refseq_ac": "XP_021326081", "gene_names_uniprotkb": "capn15", "gene_names_refseq": "capn15", "protein_names_uniprotkb": "Calpain-15 isoform X1", "protein_names_refseq": "calpain-15 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100330198); (R-DRE-1474228)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8Q9Z9", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLG9-1", "uniprot_id": "A0A8M2BLG9_DANRE", "mass": 28846.0, "length": 259, "protein_name": "Tetraspanin", "gene_name": "cd151", "organism": "Zebrafish", "refseq_name": "CD151 antigen isoform X1", "refseq_ac": "XP_005174294", "gene_names_uniprotkb": "cd151; zgc:103425", "gene_names_refseq": "cd151; zgc:103425", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "CD151 antigen isoform X1", "tax_id": 7955, "disease": "epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLH6-1", "uniprot_id": "A0A8M2BLH6_DANRE", "mass": 56858.0, "length": 532, "protein_name": "Deformed epidermal autoregulatory factor 1 homolog isoform X1", "gene_name": "deaf1", "organism": "Zebrafish", "refseq_name": "deformed epidermal autoregulatory factor 1 homolog isoform X1", "refseq_ac": "XP_005174312", "gene_names_uniprotkb": "deaf1; zgc:194895", "gene_names_refseq": "deaf1; zgc:194895", "protein_names_uniprotkb": "Deformed epidermal autoregulatory factor 1 homolog isoform X1", "protein_names_refseq": "deformed epidermal autoregulatory factor 1 homolog isoform X1", "tax_id": 7955, "disease": "Vulto-van Silfout-de Vries syndrome (Disease Ontology:DOID:0070054)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLK1-1", "uniprot_id": "A0A8M2BLK1_DANRE", "mass": 68194.0, "length": 604, "protein_name": "Zinc finger protein 319", "gene_name": "znf319b", "organism": "Zebrafish", "refseq_name": "zinc finger protein 319", "refseq_ac": "XP_005174411", "gene_names_uniprotkb": "znf319b", "gene_names_refseq": "znf319b", "protein_names_uniprotkb": "Zinc finger protein 319", "protein_names_refseq": "zinc finger protein 319", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IXT0;A0AC58IXT2;A0AC58IXT5;F1R2T0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AN56-1", "uniprot_id": "A0A8M3AN56_DANRE", "mass": 197588.0, "length": 1769, "protein_name": "Complement component c3b, tandem duplicate 2 isoform X1", "gene_name": "c3b.2", "organism": "Zebrafish", "refseq_name": "complement component c3b, tandem duplicate 2 isoform X1", "refseq_ac": "XP_009294666", "gene_names_uniprotkb": "c3b.2; si:ch211-140f21.1; wu:fc26b08", "gene_names_refseq": "c3b.2; si:ch211-140f21.1; wu:fc26b08", "protein_names_uniprotkb": "Complement component c3b, tandem duplicate 2 isoform X1", "protein_names_refseq": "complement component c3b, tandem duplicate 2 isoform X1", "tax_id": 7955, "disease": "paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); age related macular degeneration 7 (Disease Ontology:DOID:0110019); age related macular degeneration 9 (Disease Ontology:DOID:0110021); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); dry eye syndrome (Disease Ontology:DOID:10140); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); lepromatous leprosy (Disease Ontology:DOID:10887); sickle cell anemia (Disease Ontology:DOID:10923); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); factor VIII deficiency (Disease Ontology:DOID:12134); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); boutonneuse fever (Disease Ontology:DOID:14095); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); mood disorder (Disease Ontology:DOID:3324); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); arteriolosclerosis (Disease Ontology:DOID:5162); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); conjunctivitis (Disease Ontology:DOID:6195); rheumatoid arthritis (Disease Ontology:DOID:7148); complement component 3 deficiency (Disease Ontology:DOID:8354); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:566347)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15520368;24926798;30233415;32473360;32973200;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A8M3AN56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLP8-1", "uniprot_id": "A0A8M2BLP8_DANRE", "mass": 40993.0, "length": 373, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF", "gene_name": "nherf1b", "organism": "Zebrafish", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "refseq_ac": "XP_005174596", "gene_names_uniprotkb": "nherf1b", "gene_names_refseq": "nherf1b", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF", "protein_names_refseq": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "tax_id": 7955, "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078); hypertension (Disease Ontology:DOID:10763); malignant renovascular hypertension (Disease Ontology:DOID:13730)", "pathway": " (dre:100329719)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0012505 endomembrane system;GO:0016324 apical plasma membrane;GO:0030175 filopodium;GO:0001726 ruffle;GO:0005902 microvillus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLU2-1", "uniprot_id": "A0A8M2BLU2_DANRE", "mass": 77191.0, "length": 689, "protein_name": "SLIT and NTRK-like protein 1", "gene_name": "slitrk1", "organism": "Zebrafish", "refseq_name": "SLIT and NTRK-like protein 1", "refseq_ac": "XP_005174686", "gene_names_uniprotkb": "slitrk1", "gene_names_refseq": "slitrk1", "protein_names_uniprotkb": "SLIT and NTRK-like protein 1", "protein_names_refseq": "SLIT and NTRK-like protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:558743)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M2BLX5-1", "uniprot_id": "A0A8M2BLX5_DANRE", "mass": 47003.0, "length": 431, "protein_name": "Transcription factor E2F1", "gene_name": "e2f1", "organism": "Zebrafish", "refseq_name": "transcription factor E2F1", "refseq_ac": "XP_005174590", "gene_names_uniprotkb": "e2f1", "gene_names_refseq": "e2f1", "protein_names_uniprotkb": "Transcription factor E2F1", "protein_names_refseq": "transcription factor E2F1", "tax_id": 7955, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); dementia (Disease Ontology:DOID:1307); pancreatic cancer (Disease Ontology:DOID:1793); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); lung small cell carcinoma (Disease Ontology:DOID:5409); viral encephalitis (Disease Ontology:DOID:646); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dre:101885420)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0035189 Rb-E2F complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M2BLX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AGM8-1", "uniprot_id": "A0A8M3AGM8_DANRE", "mass": 44104.0, "length": 391, "protein_name": "Interleukin 2 receptor, gamma b isoform X1", "gene_name": "il2rgb", "organism": "Zebrafish", "refseq_name": "interleukin 2 receptor, gamma b isoform X1", "refseq_ac": "XP_009289358", "gene_names_uniprotkb": "il2rgb; il-2rgc.b", "gene_names_refseq": "il-2rgc.b; il2rgb", "protein_names_uniprotkb": "Interleukin 2 receptor, gamma b isoform X1", "protein_names_refseq": "interleukin 2 receptor, gamma b isoform X1", "tax_id": 7955, "disease": "X-linked severe combined immunodeficiency (Disease Ontology:DOID:0060013); COVID-19 (Disease Ontology:DOID:0080600); severe combined immunodeficiency (Disease Ontology:DOID:627); combined T cell and B cell immunodeficiency (Disease Ontology:DOID:628)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0019979 interleukin-4 binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0019221 cytokine-mediated signaling pathway;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AGM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AGP9-1", "uniprot_id": "A0A8M3AGP9_DANRE", "mass": 42919.0, "length": 393, "protein_name": "Muscleblind-like protein 3 isoform X1", "gene_name": "mbnl3", "organism": "Zebrafish", "refseq_name": "muscleblind-like protein 3 isoform X1", "refseq_ac": "XP_009289402", "gene_names_uniprotkb": "mbnl3; mbnl3a; mbnl3b; mbnl3c", "gene_names_refseq": "mbnl3a; mbnl3b; mbnl3c; mbnl3", "protein_names_uniprotkb": "Muscleblind-like protein 3 isoform X1", "protein_names_refseq": "muscleblind-like protein 3 isoform X1", "tax_id": 7955, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450)", "pathway": " (dre:567027)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AGP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AGX4-1", "uniprot_id": "A0A8M3AGX4_DANRE", "mass": 67005.0, "length": 588, "protein_name": "Transmembrane anterior posterior transformation protein 1 homolog isoform X1", "gene_name": "tapt1a", "organism": "Zebrafish", "refseq_name": "transmembrane anterior posterior transformation protein 1 homolog isoform X1", "refseq_ac": "XP_009289552", "gene_names_uniprotkb": "tapt1a", "gene_names_refseq": "tapt1a", "protein_names_uniprotkb": "Transmembrane anterior posterior transformation protein 1 homolog isoform X1", "protein_names_refseq": "transmembrane anterior posterior transformation protein 1 homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:558330)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0036064 ciliary basal body;GO:0016020 membrane", "go_biological_process": "GO:0010842 retina layer formation;GO:0001503 ossification;GO:0051216 cartilage development;GO:0048066 developmental pigmentation;GO:0002089 lens morphogenesis in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AGX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AHR8-1", "uniprot_id": "A0A8M3AHR8_DANRE", "mass": 79046.0, "length": 701, "protein_name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein", "gene_name": "zgc:162872", "organism": "Zebrafish", "refseq_name": "BAR_ACAPs and ArfGap_ACAP domain-containing protein isoform X1", "refseq_ac": "XP_009290262", "gene_names_uniprotkb": "zgc:162872; zgc:162872", "gene_names_refseq": "zgc:162872", "protein_names_uniprotkb": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein; Centaurin-beta; Cnt-b", "protein_names_refseq": "BAR_ACAPs and ArfGap_ACAP domain-containing protein isoform X1", "tax_id": 7955, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290262.1. COMPLETENESS: full length., [RefSeq]; GTPase-activating protein for the ADP ribosylation factor family., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0010008 endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AHR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AHV3-1", "uniprot_id": "A0A8M3AHV3_DANRE", "mass": 70162.0, "length": 626, "protein_name": "Ankyrin repeat domain-containing protein 13D isoform X1", "gene_name": "ankrd13d", "organism": "Zebrafish", "refseq_name": "ankyrin repeat domain-containing protein 13D isoform X1", "refseq_ac": "XP_009289324", "gene_names_uniprotkb": "ankrd13d", "gene_names_refseq": "ankrd13d", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 13D isoform X1", "protein_names_refseq": "ankyrin repeat domain-containing protein 13D isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:562931)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009289324.1. COMPLETENESS: full length., [RefSeq]; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome", "go_biological_process": "GO:0002091 negative regulation of receptor internalization;GO:0048259 regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AHV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AHY8-1", "uniprot_id": "A0A8M3AHY8_DANRE", "mass": 37646.0, "length": 347, "protein_name": "Fos-related antigen 1a isoform X1", "gene_name": "fosl1a", "organism": "Zebrafish", "refseq_name": "fos-related antigen 1a isoform X1", "refseq_ac": "XP_009289400", "gene_names_uniprotkb": "fosl1a; fosl1; sb:eu506; si:ch211-145o7.4", "gene_names_refseq": "fosl1a; fosl1; sb:eu506; si:ch211-145o7.4", "protein_names_uniprotkb": "Fos-related antigen 1a isoform X1", "protein_names_refseq": "fos-related antigen 1a isoform X1", "tax_id": 7955, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); ductal carcinoma in situ (Disease Ontology:DOID:0060074); stomach cancer (Disease Ontology:DOID:10534); colon adenocarcinoma (Disease Ontology:DOID:234); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); renal carcinoma (Disease Ontology:DOID:4451); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dre:564241)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "22931925;23000284;24024969;24637248;24947308;37664458;38381829;38385270;39072972;39360639", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133189) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AHY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AI07-1", "uniprot_id": "A0A8M3AI07_DANRE", "mass": 513564.0, "length": 4466, "protein_name": "Dynein axonemal heavy chain 11 isoform X1", "gene_name": "dnah11", "organism": "Zebrafish", "refseq_name": "dynein axonemal heavy chain 11 isoform X1", "refseq_ac": "XP_009290539", "gene_names_uniprotkb": "dnah11; si:dkey-233k19.3", "gene_names_refseq": "si:dkey-233k19.3", "protein_names_uniprotkb": "Dynein axonemal heavy chain 11 isoform X1", "protein_names_refseq": "dynein axonemal heavy chain 11 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:567790)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009290539.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AI07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AIM1-1", "uniprot_id": "A0A8M3AIM1_DANRE", "mass": 61485.0, "length": 568, "protein_name": "Max-binding protein MNT", "gene_name": "mnta", "organism": "Zebrafish", "refseq_name": "max-binding protein MNT isoform X1", "refseq_ac": "XP_009290027", "gene_names_uniprotkb": "mnta", "gene_names_refseq": "mnta", "protein_names_uniprotkb": "Max-binding protein MNT; Myc antagonist MNT", "protein_names_refseq": "max-binding protein MNT isoform X1", "tax_id": 7955, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469)", "pathway": " (dre:559570)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AIM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJ70-1", "uniprot_id": "A0A8M3AJ70_DANRE", "mass": 42609.0, "length": 374, "protein_name": "Vacuolar protein sorting-associated protein 72 homolog", "gene_name": "vps72b", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 72 homolog isoform X1", "refseq_ac": "XP_009290675", "gene_names_uniprotkb": "vps72b", "gene_names_refseq": "vps72b", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 72 homolog; Transcription factor-like 1", "protein_names_refseq": "vacuolar protein sorting-associated protein 72 homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:795272)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0000812 Swr1 complex", "go_biological_process": "GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJ70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJ79-1", "uniprot_id": "A0A8M3AJ79_DANRE", "mass": 82297.0, "length": 734, "protein_name": "Molybdenum cofactor biosynthesis protein 1", "gene_name": "mocs1", "organism": "Zebrafish", "refseq_name": "molybdenum cofactor biosynthesis protein 1 isoform X1", "refseq_ac": "XP_009291513", "gene_names_uniprotkb": "mocs1", "gene_names_refseq": "mocs1", "protein_names_uniprotkb": "Molybdenum cofactor biosynthesis protein 1; 4.1.99.22; 4.6.1.17", "protein_names_refseq": "molybdenum cofactor biosynthesis protein 1 isoform X1", "tax_id": 7955, "disease": "molybdenum cofactor deficiency type A (Disease Ontology:DOID:0111164)", "pathway": " (dre:793471)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24240475;26469318;39159974", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.99.22;4.6.1.17", "go_molecular_function": "GO:0061798 GTP 3',8'-cyclase activity;GO:0061799 cyclic pyranopterin monophosphate synthase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AJ79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJG6-1", "uniprot_id": "A0A8M3AJG6_DANRE", "mass": 1003641.0, "length": 9355, "protein_name": "Protein piccolo", "gene_name": "pclob", "organism": "Zebrafish", "refseq_name": "uncharacterized protein pclob isoform X1", "refseq_ac": "XP_009291733", "gene_names_uniprotkb": "pclob", "gene_names_refseq": "pclob", "protein_names_uniprotkb": "Protein piccolo; Aczonin", "protein_names_refseq": "uncharacterized protein pclob isoform X1", "tax_id": 7955, "disease": "pontocerebellar hypoplasia type 3 (Disease Ontology:DOID:0060272)", "pathway": " (dre:565842)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009291733.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0030424 axon;GO:0048788 cytoskeleton of presynaptic active zone;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0035418 protein localization to synapse;GO:1904071 presynaptic active zone assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJH8-1", "uniprot_id": "A0A8M3AJH8_DANRE", "mass": 116679.0, "length": 1027, "protein_name": "Serine/threonine-protein kinase Nek10", "gene_name": "nek10", "organism": "Zebrafish", "refseq_name": "serine/threonine-protein kinase Nek10", "refseq_ac": "XP_009290963", "gene_names_uniprotkb": "nek10", "gene_names_refseq": "nek10", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek10; 2.7.11.1; Never in mitosis A-related kinase 10", "protein_names_refseq": "serine/threonine-protein kinase Nek10", "tax_id": 7955, "disease": "primary ciliary dyskinesia 44 (Disease Ontology:DOID:0111851)", "pathway": " (dre:100333839)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:1902911 protein kinase complex", "go_biological_process": "GO:0048513 animal organ development;GO:1902749 regulation of cell cycle G2/M phase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJH9-1", "uniprot_id": "A0A8M3AJH9_DANRE", "mass": 87621.0, "length": 805, "protein_name": "MTSS I-BAR domain containing 2a isoform X1", "gene_name": "mtss1la", "organism": "Zebrafish", "refseq_name": "MTSS I-BAR domain containing 2a isoform X1", "refseq_ac": "XP_009291775", "gene_names_uniprotkb": "mtss1la; id:ibd5126; mtss1l; si:ch211-15i6.4", "gene_names_refseq": "id:ibd5126; mtss1la; mtss1l; si:ch211-15i6.4", "protein_names_uniprotkb": "MTSS I-BAR domain containing 2a isoform X1", "protein_names_refseq": "MTSS I-BAR domain containing 2a isoform X1", "tax_id": 7955, "disease": "intellectual developmental disorder with ocular anomalies and distinctive facial features (Disease Ontology:DOID:0081301)", "pathway": " (dre:560413)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11731487;26469318;35886872", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007009 plasma membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3AJH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJI3-1", "uniprot_id": "A0A8M3AJI3_DANRE", "mass": 63651.0, "length": 558, "protein_name": "Hyaluronan synthase 3 isoform X1", "gene_name": "has3", "organism": "Zebrafish", "refseq_name": "hyaluronan synthase 3 isoform X1", "refseq_ac": "XP_009291796", "gene_names_uniprotkb": "has3; af190743gs2; dg42III; xx:af190743gs1; xx:af190743gs2", "gene_names_refseq": "af190743gs2; dg42III; has3; xx:af190743gs1; xx:af190743gs2", "protein_names_uniprotkb": "Hyaluronan synthase 3 isoform X1", "protein_names_refseq": "hyaluronan synthase 3 isoform X1", "tax_id": 7955, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dre:282555)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14729574;24067352;26156497;26828861;27189481;27434666;28207787;34942099;35710880;37272628", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0030213 hyaluronan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A8M3AJI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AJX9-1", "uniprot_id": "A0A8M3AJX9_DANRE", "mass": 221097.0, "length": 2040, "protein_name": "HEAT repeat-containing protein 5A", "gene_name": "heatr5a", "organism": "Zebrafish", "refseq_name": "HEAT repeat-containing protein 5A isoform X1", "refseq_ac": "XP_009291396", "gene_names_uniprotkb": "heatr5a; CG2747; si:busm1-142b24.3; si:dz142b24.3; zgc:63665", "gene_names_refseq": "CG2747; heatr5a; si:busm1-142b24.3; si:dz142b24.3; zgc:63665", "protein_names_uniprotkb": "HEAT repeat-containing protein 5A", "protein_names_refseq": "HEAT repeat-containing protein 5A isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009291396.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E7F1I7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AJX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AK24-1", "uniprot_id": "A0A8M3AK24_DANRE", "mass": 40911.0, "length": 362, "protein_name": "Glutaminyl-peptide cyclotransferase", "gene_name": "qpct", "organism": "Zebrafish", "refseq_name": "glutaminyl-peptide cyclotransferase precursor", "refseq_ac": "NP_001429608", "gene_names_uniprotkb": "qpct", "gene_names_refseq": "qpct", "protein_names_uniprotkb": "Glutaminyl-peptide cyclotransferase; 2.3.2.5; Glutaminyl cyclase; Glutaminyl-tRNA cyclotransferase", "protein_names_refseq": "glutaminyl-peptide cyclotransferase precursor", "tax_id": 7955, "disease": "", "pathway": " (dre:795685)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588733.609801.1, GDQQ01061725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000017.1. On Aug 20, 2025 this sequence version replaced XP_009291517.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.5", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016603 glutaminyl-peptide cyclotransferase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AK24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AK66-1", "uniprot_id": "A0A8M3AK66_DANRE", "mass": 45396.0, "length": 395, "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "serpina10b", "organism": "Zebrafish", "refseq_name": "protein Z-dependent protease inhibitor", "refseq_ac": "XP_009291625", "gene_names_uniprotkb": "serpina10b", "gene_names_refseq": "serpina10b", "protein_names_uniprotkb": "Protein Z-dependent protease inhibitor", "protein_names_refseq": "protein Z-dependent protease inhibitor", "tax_id": 7955, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); thrombophilia (Disease Ontology:DOID:2452)", "pathway": " (dre:100003661)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133192) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009291625.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58HPB1", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation;GO:0030195 negative regulation of blood coagulation;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AK66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AKE8-1", "uniprot_id": "A0A8M3AKE8_DANRE", "mass": 119721.0, "length": 1114, "protein_name": "Multiple epidermal growth factor-like domains protein 11 isoform X1", "gene_name": "megf11", "organism": "Zebrafish", "refseq_name": "multiple epidermal growth factor-like domains protein 11 isoform X1", "refseq_ac": "XP_009291879", "gene_names_uniprotkb": "megf11", "gene_names_refseq": "megf11", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 11 isoform X1", "protein_names_refseq": "multiple epidermal growth factor-like domains protein 11 isoform X1", "tax_id": 7955, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)", "pathway": " (dre:563468); (R-DRE-381426); (R-DRE-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1Q4V3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005604 basement membrane", "go_biological_process": "GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AKE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AKJ6-1", "uniprot_id": "A0A8M3AKJ6_DANRE", "mass": 110332.0, "length": 984, "protein_name": "Nicotinamide phosphoribosyltransferase", "gene_name": "nampt3.1", "organism": "Zebrafish", "refseq_name": "uncharacterized protein nampt3.1", "refseq_ac": "XP_009292044", "gene_names_uniprotkb": "nampt3.1", "gene_names_refseq": "nampt3.1", "protein_names_uniprotkb": "Nicotinamide phosphoribosyltransferase; 2.4.2.12", "protein_names_refseq": "uncharacterized protein nampt3.1", "tax_id": 7955, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary hypertension (Disease Ontology:DOID:6432); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dre:100149018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009292044.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.12", "go_molecular_function": "GO:0047280 nicotinamide phosphoribosyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0009435 NAD+ biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AKJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AKQ7-1", "uniprot_id": "A0A8M3AKQ7_DANRE", "mass": 19599.0, "length": 180, "protein_name": "Transmembrane protein 196", "gene_name": "tmem196a", "organism": "Zebrafish", "refseq_name": "transmembrane protein 196 isoform X3", "refseq_ac": "XP_009292217", "gene_names_uniprotkb": "tmem196a; tmem196", "gene_names_refseq": "tmem196", "protein_names_uniprotkb": "Transmembrane protein 196", "protein_names_refseq": "transmembrane protein 196 isoform X3", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AKQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AKR9-1", "uniprot_id": "A0A8M3AKR9_DANRE", "mass": 170195.0, "length": 1533, "protein_name": "Zinc finger protein 646 isoform X1", "gene_name": "si:dkey-89b17.4", "organism": "Zebrafish", "refseq_name": "zinc finger protein 646 isoform X1", "refseq_ac": "XP_009292269", "gene_names_uniprotkb": "si:dkey-89b17.4", "gene_names_refseq": "si:dkey-89b17.4", "protein_names_uniprotkb": "Zinc finger protein 646 isoform X1", "protein_names_refseq": "zinc finger protein 646 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:336271)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "H0WFD2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AKR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AKU3-1", "uniprot_id": "A0A8M3AKU3_DANRE", "mass": 410755.0, "length": 3624, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 34", "gene_name": "usp34", "organism": "Zebrafish", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 34", "refseq_ac": "XP_009292973", "gene_names_uniprotkb": "usp34", "gene_names_refseq": "usp34", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 34; 3.4.19.12; Deubiquitinating enzyme 34; Ubiquitin thioesterase 34; Ubiquitin-specific-processing protease 34", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 34", "tax_id": 7955, "disease": "", "pathway": " (dre:562779)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XP_009292973.2. COMPLETENESS: full length., [RefSeq]; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AKU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AKV9-1", "uniprot_id": "A0A8M3AKV9_DANRE", "mass": 125973.0, "length": 1142, "protein_name": "Syntaxin-binding protein 5-like", "gene_name": "stxbp5a", "organism": "Zebrafish", "refseq_name": "syntaxin-binding protein 5a isoform X1", "refseq_ac": "XP_009293002", "gene_names_uniprotkb": "stxbp5a; si:ch211-279m15.2", "gene_names_refseq": "si:ch211-279m15.2; stxbp5a", "protein_names_uniprotkb": "Syntaxin-binding protein 5-like", "protein_names_refseq": "syntaxin-binding protein 5a isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:556789)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "26469318;26818140;27189481;28252024;35226401", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133195) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8M3AKV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ALR8-1", "uniprot_id": "A0A8M3ALR8_DANRE", "mass": 65776.0, "length": 588, "protein_name": "Drebrin", "gene_name": "dbn1", "organism": "Zebrafish", "refseq_name": "drebrin", "refseq_ac": "XP_009293891", "gene_names_uniprotkb": "dbn1", "gene_names_refseq": "dbn1", "protein_names_uniprotkb": "Drebrin; Developmentally-regulated brain protein", "protein_names_refseq": "drebrin", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cognitive disorder (Disease Ontology:DOID:1561); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dre:561153)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0030425 dendrite;GO:0030426 growth cone;GO:0070161 anchoring junction", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ALR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AM98-1", "uniprot_id": "A0A8M3AM98_DANRE", "mass": 109112.0, "length": 969, "protein_name": "Connector enhancer of kinase suppressor of ras 2 isoform X1", "gene_name": "cnksr2b", "organism": "Zebrafish", "refseq_name": "connector enhancer of kinase suppressor of ras 2 isoform X1", "refseq_ac": "XP_009293705", "gene_names_uniprotkb": "cnksr2b", "gene_names_refseq": "cnksr2b", "protein_names_uniprotkb": "Connector enhancer of kinase suppressor of ras 2 isoform X1", "protein_names_refseq": "connector enhancer of kinase suppressor of ras 2 isoform X1", "tax_id": 7955, "disease": "syndromic X-linked mental retardation Hough type (Disease Ontology:DOID:0080242)", "pathway": " (dre:558834)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0007167 enzyme-linked receptor protein signaling pathway;GO:0099084 postsynaptic specialization organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AM98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AN32-1", "uniprot_id": "A0A8M3AN32_DANRE", "mass": 115422.0, "length": 1060, "protein_name": "Uncharacterized protein KIAA1614 homolog isoform X1", "gene_name": "si:dkey-121a11.3", "organism": "Zebrafish", "refseq_name": "uncharacterized protein KIAA1614 homolog isoform X1", "refseq_ac": "XP_009294606", "gene_names_uniprotkb": "si:dkey-121a11.3", "gene_names_refseq": "si:dkey-121a11.3", "protein_names_uniprotkb": "Uncharacterized protein KIAA1614 homolog isoform X1", "protein_names_refseq": "uncharacterized protein KIAA1614 homolog isoform X1", "tax_id": 7955, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133197) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0AC58IF91;F1QDI4;F1R6J1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0007098 centrosome cycle;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AN32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANW4-1", "uniprot_id": "A0A8M3ANW4_DANRE", "mass": 123424.0, "length": 1130, "protein_name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1", "gene_name": "agap2", "organism": "Zebrafish", "refseq_name": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1", "refseq_ac": "XP_009295321", "gene_names_uniprotkb": "agap2; zgc:153779", "gene_names_refseq": "agap2; zgc:153779", "protein_names_uniprotkb": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1", "protein_names_refseq": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1", "tax_id": 7955, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dre:565109)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25739401;28252024;31680844", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007507 heart development;GO:0001944 vasculature development;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8M3ANW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANU1-1", "uniprot_id": "A0A8M3ANU1_DANRE", "mass": 457520.0, "length": 4007, "protein_name": "Dynein axonemal heavy chain 3", "gene_name": "dnah3", "organism": "Zebrafish", "refseq_name": "dynein axonemal heavy chain 3 isoform X1", "refseq_ac": "XP_068073364", "gene_names_uniprotkb": "dnah3", "gene_names_refseq": "dnah3", "protein_names_uniprotkb": "Dynein axonemal heavy chain 3; Axonemal beta dynein heavy chain 3; Ciliary dynein heavy chain 3", "protein_names_refseq": "dynein axonemal heavy chain 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100334351)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133199) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005858 axonemal dynein complex", "go_biological_process": "GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ANU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANW6-1", "uniprot_id": "A0A8M3ANW6_DANRE", "mass": 122905.0, "length": 1124, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "hipk1a", "organism": "Zebrafish", "refseq_name": "LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 1", "refseq_ac": "XP_009295328", "gene_names_uniprotkb": "hipk1a", "gene_names_refseq": "hipk1a", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 1", "tax_id": 7955, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162)", "pathway": " (dre:572042)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## internal stop codons :: corrected 1 genomic stop codon ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009295328.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.13;2.7.11.25;2.7.10.1;2.7.11.22;2.7.11.21;2.7.11.17;2.7.12.1;2.7.12.2;2.7.11.24;2.7.10.2;2.7.11.23;2.7.1.150;2.7.11.12;2.7.11.39;2.7.11.11;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.26;2.7.11.31", "go_molecular_function": "GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ANW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ANX4-1", "uniprot_id": "A0A8M3ANX4_DANRE", "mass": 59713.0, "length": 540, "protein_name": "5-hydroxytryptamine receptor 6", "gene_name": "htr6", "organism": "Zebrafish", "refseq_name": "5-hydroxytryptamine receptor 6", "refseq_ac": "XP_009295353", "gene_names_uniprotkb": "htr6", "gene_names_refseq": "htr6", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 6; Serotonin receptor 6", "protein_names_refseq": "5-hydroxytryptamine receptor 6", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dre:568269)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133198) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009295353.1. COMPLETENESS: full length., [RefSeq]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of mTOR signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0023056 positive regulation of signaling;GO:0010647 positive regulation of cell communication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ANX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AP98-1", "uniprot_id": "A0A8M3AP98_DANRE", "mass": 48890.0, "length": 436, "protein_name": "vesicle-fusing ATPase", "gene_name": "vps4a", "organism": "Zebrafish", "refseq_name": "vacuolar protein sorting-associated protein 4A isoform X1", "refseq_ac": "XP_009296449", "gene_names_uniprotkb": "vps4a; zgc:153907", "gene_names_refseq": "vps4a; zgc:153907", "protein_names_uniprotkb": "vesicle-fusing ATPase; 3.6.4.6", "protein_names_refseq": "vacuolar protein sorting-associated protein 4A isoform X1", "tax_id": 7955, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0031902 late endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0009653 anatomical structure morphogenesis;GO:0051931 regulation of sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AP98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APF0-1", "uniprot_id": "A0A8M3APF0_DANRE", "mass": 116603.0, "length": 1027, "protein_name": "Formin-like protein 1 isoform X1", "gene_name": "fmnl1b", "organism": "Zebrafish", "refseq_name": "formin-like 1b", "refseq_ac": "NP_001429487", "gene_names_uniprotkb": "fmnl1b", "gene_names_refseq": "fmnl1b; fmnl1", "protein_names_uniprotkb": "Formin-like protein 1 isoform X1", "protein_names_refseq": "formin-like 1b; formin-like 1; zmp:0000001155", "tax_id": 7955, "disease": "", "pathway": " (dre:100536330)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01019170.1, SRR32588730.1153425.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JBMGRA010000024.1. On Aug 13, 2025 this sequence version replaced XP_009295890.5., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0016477 cell migration;GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APH7-1", "uniprot_id": "A0A8M3APH7_DANRE", "mass": 108842.0, "length": 985, "protein_name": "Angiomotin-like protein 1 isoform X1", "gene_name": "amotl1", "organism": "Zebrafish", "refseq_name": "angiomotin-like protein 1 isoform X1", "refseq_ac": "XP_009289694", "gene_names_uniprotkb": "amotl1", "gene_names_refseq": "amotl1", "protein_names_uniprotkb": "Angiomotin-like protein 1 isoform X1", "protein_names_refseq": "angiomotin-like protein 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:101884950); (R-DRE-2028269)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E7FCE7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APM4-1", "uniprot_id": "A0A8M3APM4_DANRE", "mass": 73172.0, "length": 645, "protein_name": "Myxovirus (Influenza virus) resistance G isoform X1", "gene_name": "mxg", "organism": "Zebrafish", "refseq_name": "myxovirus (influenza virus) resistance G isoform X1", "refseq_ac": "XP_009296165", "gene_names_uniprotkb": "mxg", "gene_names_refseq": "mxg", "protein_names_uniprotkb": "Myxovirus (Influenza virus) resistance G isoform X1", "protein_names_refseq": "myxovirus (influenza virus) resistance G isoform X1", "tax_id": 7955, "disease": "Charcot-Marie-Tooth disease dominant intermediate B (Disease Ontology:DOID:0110197); centronuclear myopathy 1 (Disease Ontology:DOID:0111223); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); microcytic anemia (Disease Ontology:DOID:11252); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133200) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_009296165.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0051607 defense response to virus;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3APQ8-1", "uniprot_id": "A0A8M3APQ8_DANRE", "mass": 28507.0, "length": 257, "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase", "gene_name": "si:ch211-145b13.6", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:ch211-145b13.6", "refseq_ac": "XP_009289877", "gene_names_uniprotkb": "si:ch211-145b13.6", "gene_names_refseq": "si:ch211-145b13.6", "protein_names_uniprotkb": "NAD(P)(+)--arginine ADP-ribosyltransferase; 2.4.2.31; Mono(ADP-ribosyl)transferase", "protein_names_refseq": "uncharacterized protein si:ch211-145b13.6", "tax_id": 7955, "disease": "", "pathway": " (dre:100317105)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.31", "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3APQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0S5V5-1", "uniprot_id": "B0S5V5_DANRE", "mass": 29843.0, "length": 265, "protein_name": "protein-serine/threonine phosphatase", "gene_name": "ctdsp1", "organism": "Zebrafish", "refseq_name": "carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2", "refseq_ac": "XP_009303177", "gene_names_uniprotkb": "ctdsp1", "gene_names_refseq": "ctdsp1", "protein_names_uniprotkb": "protein-serine/threonine phosphatase; 3.1.3.16", "protein_names_refseq": "carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2", "tax_id": 7955, "disease": "", "pathway": " (dre:553744)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3B5V3", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.67;3.1.3.27", "go_molecular_function": "GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0S5V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8A5Q1-1", "uniprot_id": "B8A5Q1_DANRE", "mass": 60349.0, "length": 533, "protein_name": "Cytochrome P450 2U1", "gene_name": "cyp2u1", "organism": "Zebrafish", "refseq_name": "cytochrome P450 2U1", "refseq_ac": "NP_001139036", "gene_names_uniprotkb": "cyp2u1", "gene_names_refseq": "cyp2u1", "protein_names_uniprotkb": "Cytochrome P450 2U1; 1.14.14.80; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "cytochrome P450 2U1", "tax_id": 7955, "disease": "hereditary spastic paraplegia 56 (Disease Ontology:DOID:0110808)", "pathway": " (dre:556280); (R-DRE-211958); (R-DRE-2142816)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21087487;21116621;25526262;26469318;28411468;28514663", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GDQH01020108.1, GFIL01007979.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000001.1. On Mar 5, 2009 this sequence version replaced XP_684136.2., [RefSeq]; A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NT45", "ec_number_list": "1.14.14.80;1.14.14.1;1.14.14.14", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0008202 steroid metabolic process;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B8A5Q1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0V0E6-1", "uniprot_id": "B0V0E6_DANRE", "mass": 20505.0, "length": 184, "protein_name": "Uncharacterized protein si:dkey-192g7.3", "gene_name": "si:dkey-192g7.3", "organism": "Zebrafish", "refseq_name": "uncharacterized protein si:dkey-192g7.3", "refseq_ac": "XP_009303125", "gene_names_uniprotkb": "si:dkey-192g7.3", "gene_names_refseq": "si:dkey-192g7.3", "protein_names_uniprotkb": "Uncharacterized protein si:dkey-192g7.3", "protein_names_refseq": "uncharacterized protein si:dkey-192g7.3", "tax_id": 7955, "disease": "", "pathway": " (dre:100321723)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133184) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AW76", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0031295 T cell costimulation;GO:0042130 negative regulation of T cell proliferation;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0V0E6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A5PMA3-1", "uniprot_id": "A5PMA3_DANRE", "mass": 51774.0, "length": 461, "protein_name": "Fibrinogen C domain-containing protein 1", "gene_name": "fibcd1b", "organism": "Zebrafish", "refseq_name": "fibrinogen C domain-containing protein 1", "refseq_ac": "NP_001122015", "gene_names_uniprotkb": "fibcd1b; fibcd1; si:dkey-54o1.1", "gene_names_refseq": "fibcd1b; fibcd1; si:dkey-54o1.1", "protein_names_uniprotkb": "Fibrinogen C domain-containing protein 1", "protein_names_refseq": "fibrinogen C domain containing 1; fibrinogen C domain-containing protein 1", "tax_id": 7955, "disease": "", "pathway": " (dre:567525)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23118857;27189481;28252024", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA4476762, SAMEA4476784 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On Jul 31, 2008 this sequence version replaced XP_695913.3., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NK69", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0016020 membrane;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A5PMA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8A5L1-1", "uniprot_id": "B8A5L1_DANRE", "mass": 206047.0, "length": 1867, "protein_name": "Proteasome adapter and scaffold protein ECM29 isoform 1", "gene_name": "ecpas", "organism": "Zebrafish", "refseq_name": "proteasome adapter and scaffold protein ECM29 isoform 1", "refseq_ac": "NP_001155958", "gene_names_uniprotkb": "ecpas; fbxo10; kiaa0368; si:dkey-245p14.6; si:dkey-245p14.7", "gene_names_refseq": "ecpas; fbxo10; kiaa0368; si:dkey-245p14.6; si:dkey-245p14.7", "protein_names_uniprotkb": "Proteasome adapter and scaffold protein ECM29 isoform 1", "protein_names_refseq": "F-box protein 10; proteasome adapter and scaffold protein ECM29 isoform 1; zmp:0000000700", "tax_id": 7955, "disease": "", "pathway": " (dre:563777)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26469318;28252024", "class_list": "", "function": "VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jun 25, 2025 this sequence version replaced NP_001155958.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NT70", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0005634 nucleus", "go_biological_process": "GO:0043248 proteasome assembly;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B8A5L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8A5N0-1", "uniprot_id": "B8A5N0_DANRE", "mass": 54782.0, "length": 494, "protein_name": "BAG family molecular chaperone regulator 5", "gene_name": "bag5", "organism": "Zebrafish", "refseq_name": "BAG family molecular chaperone regulator 5 isoform 1", "refseq_ac": "NP_001029355", "gene_names_uniprotkb": "bag5; zgc:114117", "gene_names_refseq": "bag5; zgc:114117", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 5; Bcl-2-associated athanogene 5", "protein_names_refseq": "BAG family molecular chaperone regulator 5 isoform 1", "tax_id": 7955, "disease": "dilated cardiomyopathy 2F (Disease Ontology:DOID:0081162)", "pathway": " (dre:569580)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26469318;28252024;30929901;33942360", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC097176.1, SRR32588727.1031282.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505373 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On or before Jun 24, 2024 this sequence version replaced XP_021336323.1, NP_001029355.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M9Q9W2", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B8A5N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A5PLH4-1", "uniprot_id": "TM2D1_DANRE", "mass": 22206.0, "length": 197, "protein_name": "TM2 domain-containing protein 1", "gene_name": "tm2d1", "organism": "Zebrafish", "refseq_name": "TM2 domain-containing protein 1 precursor", "refseq_ac": "NP_001092733", "gene_names_uniprotkb": "tm2d1; si:ch211-112f11.3", "gene_names_refseq": "si:ch211-112f11.3; tm2d1", "protein_names_uniprotkb": "TM2 domain-containing protein 1", "protein_names_refseq": "TM2 domain-containing protein 1 precursor; TM2 domain-containing protein 1", "tax_id": 7955, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dre:100093710)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC142903.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC142903.1., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A8DZE2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PLH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0S6S9-1", "uniprot_id": "RBM44_DANRE", "mass": 106589.0, "length": 956, "protein_name": "RNA-binding protein 44", "gene_name": "rbm44", "organism": "Zebrafish", "refseq_name": "RNA-binding protein 44", "refseq_ac": "NP_001122014", "gene_names_uniprotkb": "rbm44; fi04c05; si:dkey-189g17.2; si:dkey-89p3.3; wu:fi04c05", "gene_names_refseq": "fi04c05; rbm44; si:dkey-189g17.2; si:dkey-89p3.3; wu:fi04c05", "protein_names_uniprotkb": "RNA-binding protein 44; RNA-binding motif protein 44", "protein_names_refseq": "RNA-binding protein 44", "tax_id": 7955, "disease": "", "pathway": " (dre:567482)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01032339.1, SRR32588733.1065421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA898399, SAMEA898400 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000009.1. On Jul 31, 2008 this sequence version replaced XP_695871.3., [RefSeq]; Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045171 intercellular bridge", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0S6S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A9C3W3-1", "uniprot_id": "KAZRA_DANRE", "mass": 88931.0, "length": 786, "protein_name": "Kazrin-A", "gene_name": "kazna", "organism": "Zebrafish", "refseq_name": "kazrin-A", "refseq_ac": "NP_001121761", "gene_names_uniprotkb": "kazna; kaza; si:dkey-159f12.3", "gene_names_refseq": "kaza; kazna; si:dkey-159f12.3", "protein_names_uniprotkb": "Kazrin-A", "protein_names_refseq": "kazrin-A", "tax_id": 7955, "disease": "", "pathway": " (dre:100003663); (R-DRE-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588722.39188397.1, SRR32588725.49395450.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Jul 31, 2008 this sequence version replaced XP_001343166.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9C3W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0S7C3-1", "uniprot_id": "B0S7C3_DANRE", "mass": 83470.0, "length": 719, "protein_name": "Upstream binding transcription factor, like isoform X1", "gene_name": "ubtfl", "organism": "Zebrafish", "refseq_name": "upstream binding transcription factor, like isoform 1", "refseq_ac": "NP_001430154", "gene_names_uniprotkb": "ubtfl; Tcfubf; zgc:63557", "gene_names_refseq": "Tcfubf; ubtfl; zgc:63557", "protein_names_uniprotkb": "Upstream binding transcription factor, like isoform X1", "protein_names_refseq": "upstream binding transcription factor, like isoform 1", "tax_id": 7955, "disease": "childhood-onset neurodegeneration with brain atrophy (Disease Ontology:DOID:0070474)", "pathway": " (dre:393978)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01042629.1, SRR32588727.1254052.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000002.1. On Sep 8, 2025 this sequence version replaced XP_005163543.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BAT3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006360 transcription by RNA polymerase I;GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0S7C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0S5B5-1", "uniprot_id": "B0S5B5_DANRE", "mass": 78820.0, "length": 692, "protein_name": "Relaxin receptor 1 isoform X1", "gene_name": "rxfp2l", "organism": "Zebrafish", "refseq_name": "relaxin receptor 1 isoform X1", "refseq_ac": "XP_001919542", "gene_names_uniprotkb": "rxfp2l", "gene_names_refseq": "rxfp2l", "protein_names_uniprotkb": "Relaxin receptor 1 isoform X1", "protein_names_refseq": "relaxin receptor 1 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:558546)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Mar 23, 2011 this sequence version replaced XP_001919542.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1QKB0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0S5B5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A8WHN3-1", "uniprot_id": "A8WHN3_DANRE", "mass": 17803.0, "length": 167, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim17-B", "gene_name": "timm17b", "organism": "Zebrafish", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim17-B", "refseq_ac": "NP_001107065", "gene_names_uniprotkb": "timm17b; si:ch211-163b2.6", "gene_names_refseq": "si:ch211-163b2.6; timm17b", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim17-B", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim17-B", "tax_id": 7955, "disease": "", "pathway": " (dre:562144); (R-DRE-1268020)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "28252024;28631837;31094706", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH500288.1, SRR32588718.8083392.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505372 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000008.1. On Mar 2, 2008 this sequence version replaced XP_690636.1., [RefSeq]; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NH04", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A8WHN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0UXL9-1", "uniprot_id": "B0UXL9_DANRE", "mass": 49194.0, "length": 465, "protein_name": "Arf-GAP domain and FG repeat-containing protein 1b", "gene_name": "agfg1b", "organism": "Zebrafish", "refseq_name": "arf-GAP domain and FG repeat-containing protein 1b", "refseq_ac": "NP_956882", "gene_names_uniprotkb": "agfg1b; zgc:66055", "gene_names_refseq": "agfg1b; zgc:66055", "protein_names_uniprotkb": "Arf-GAP domain and FG repeat-containing protein 1b", "protein_names_refseq": "DKEYP-13A3.4; arf-GAP domain and FG repeat-containing protein 1b", "tax_id": 7955, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311)", "pathway": " (dre:393560); (R-DRE-8856825)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "26469318;27189481;28252024;30515132", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC056733.1, GDQH01009935.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000002.1. On Sep 30, 2011 this sequence version replaced NP_956882.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PFE8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001675 acrosome assembly;GO:0007289 spermatid nucleus differentiation;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0UXL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AS70-1", "uniprot_id": "A0A8M3AS70_DANRE", "mass": 144773.0, "length": 1302, "protein_name": "Uncharacterized protein cngb1a isoform X1", "gene_name": "cngb1a", "organism": "Zebrafish", "refseq_name": "uncharacterized protein cngb1a isoform X1", "refseq_ac": "XP_009292121", "gene_names_uniprotkb": "cngb1a", "gene_names_refseq": "cngb1a", "protein_names_uniprotkb": "Uncharacterized protein cngb1a isoform X1", "protein_names_refseq": "uncharacterized protein cngb1a isoform X1", "tax_id": 7955, "disease": "retinitis pigmentosa 45 (Disease Ontology:DOID:0110402); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dre:568211)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133193) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;1.5.1.2", "go_molecular_function": "GO:0030553 cGMP binding;GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AS70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ASW8-1", "uniprot_id": "A0A8M3ASW8_DANRE", "mass": 252023.0, "length": 2164, "protein_name": "Centriolin isoform X1", "gene_name": "cntrl", "organism": "Zebrafish", "refseq_name": "centriolin isoform X1", "refseq_ac": "XP_009300206", "gene_names_uniprotkb": "cntrl", "gene_names_refseq": "cntrl", "protein_names_uniprotkb": "Centriolin isoform X1", "protein_names_refseq": "centriolin isoform X1", "tax_id": 7955, "disease": "nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (dre:100334259)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ASW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A5PMU4-1", "uniprot_id": "ANS1B_DANRE", "mass": 141494.0, "length": 1280, "protein_name": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B", "gene_name": "anks1b", "organism": "Zebrafish", "refseq_name": "ankyrin repeat and sterile alpha motif domain-containing protein 1B", "refseq_ac": "NP_001093487", "gene_names_uniprotkb": "anks1b; si:ch211-146a9.3; si:ch211-211o1.2; si:dkey-11k24.3", "gene_names_refseq": "anks1b; si:ch211-146a9.3; si:dkey-11k24.3", "protein_names_uniprotkb": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B", "protein_names_refseq": "ankyrin repeat and sterile alpha motif domain-containing protein 1B; cajalin 2", "tax_id": 7955, "disease": "", "pathway": " (dre:565408)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23594743", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588731.596506.1, SRR32588727.2461253.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000004.1. On Jul 26, 2007 this sequence version replaced XP_693780.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0099523 presynaptic cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:1900383 regulation of synaptic plasticity by receptor localization to synapse", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PMU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3AQV5-1", "uniprot_id": "A0A8M3AQV5_DANRE", "mass": 105030.0, "length": 921, "protein_name": "Thyroid hormone receptor-associated protein 3 isoform X1", "gene_name": "thrap3a", "organism": "Zebrafish", "refseq_name": "thyroid hormone receptor-associated protein 3 isoform X1", "refseq_ac": "XP_068070271", "gene_names_uniprotkb": "thrap3a", "gene_names_refseq": "thrap3a", "protein_names_uniprotkb": "Thyroid hormone receptor-associated protein 3 isoform X1", "protein_names_refseq": "thyroid hormone receptor-associated protein 3 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:570454)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2R8RHG4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3AQV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A5D8S0-1", "uniprot_id": "KIZ_DANRE", "mass": 79481.0, "length": 706, "protein_name": "Centrosomal protein kizuna", "gene_name": "kiz", "organism": "Zebrafish", "refseq_name": "centrosomal protein kizuna", "refseq_ac": "NP_001091860", "gene_names_uniprotkb": "kiz; plk1s1; zgc:162576", "gene_names_refseq": "kiz; plk1s1; zgc:162576", "protein_names_uniprotkb": "Centrosomal protein kizuna; Polo-like kinase 1 substrate 1", "protein_names_refseq": "centrosomal protein kizuna; polo-like kinase 1 substrate 1", "tax_id": 7955, "disease": "retinitis pigmentosa 69 (Disease Ontology:DOID:0110410)", "pathway": " (dre:567100)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC141787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC141787.1. On May 30, 2007 this sequence version replaced XP_706403.2., [RefSeq]; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D8S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8JKI0-1", "uniprot_id": "B8JKI0_DANRE", "mass": 18646.0, "length": 173, "protein_name": "PEST proteolytic signal-containing nuclear protein", "gene_name": "pcnp", "organism": "Zebrafish", "refseq_name": "PEST proteolytic signal-containing nuclear protein isoform a", "refseq_ac": "NP_001313645", "gene_names_uniprotkb": "pcnp; zgc:103440", "gene_names_refseq": "pcnp; zgc:103440", "protein_names_uniprotkb": "PEST proteolytic signal-containing nuclear protein", "protein_names_refseq": "PEST proteolytic signal-containing nuclear protein isoform a", "tax_id": 7955, "disease": "", "pathway": " (dre:450014)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;27189481;36564370", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EH440504.1, SRR32588729.35726461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505373, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On Jun 25, 2025 this sequence version replaced NP_001313645.1. Transcript Variant: This variant (1) encodes the longest isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May be involved in cell cycle regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1P872", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8JKI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8M3ASV5-1", "uniprot_id": "A0A8M3ASV5_DANRE", "mass": 44629.0, "length": 396, "protein_name": "Double C2-like domain-containing protein", "gene_name": "doc2b", "organism": "Zebrafish", "refseq_name": "double C2-like domain-containing protein beta isoform X6", "refseq_ac": "XP_009300178", "gene_names_uniprotkb": "doc2b", "gene_names_refseq": "doc2b", "protein_names_uniprotkb": "Double C2-like domain-containing protein", "protein_names_refseq": "double C2-like domain-containing protein beta isoform X6", "tax_id": 7955, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (dre:100006713)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0045202 synapse;GO:0030658 transport vesicle membrane;GO:0098793 presynapse;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045956 positive regulation of calcium ion-dependent exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8M3ASV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A8DZE7-1", "uniprot_id": "D42E1_DANRE", "mass": 43595.0, "length": 387, "protein_name": "Short-chain dehydrogenase/reductase family 42E member 1", "gene_name": "sdr42e1", "organism": "Zebrafish", "refseq_name": "short-chain dehydrogenase/reductase family 42E member 1 isoform 2", "refseq_ac": "NP_001032779", "gene_names_uniprotkb": "sdr42e1; si:ch211-79l17.4; zgc:123280", "gene_names_refseq": "sdr42e1; si:ch211-79l17.4; zgc:123280", "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase family 42E member 1; 1.1.1.-", "protein_names_refseq": "3-beta-HSD family protein HSPC105 homolog A; short-chain dehydrogenase/reductase family 42E member 1 isoform 2", "tax_id": 7955, "disease": "", "pathway": " (dre:565964)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23594743;31053140", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC109446.1, SRR32588725.27699251.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505372, SAMEA3505374 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000018.1. On Jun 26, 2025 this sequence version replaced NP_001032779.2. Transcript Variant: This variant (2) contains an alternate exon in the CDS, resulting in an alternate N-terminus compared to variant 1. The encoded isoform (2) is longer than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32LS5", "ec_number_list": "", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A8DZE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A5PMY1-1", "uniprot_id": "A5PMY1_DANRE", "mass": 34104.0, "length": 319, "protein_name": "Regulating synaptic membrane exocytosis protein 3 isoform X1", "gene_name": "rims3", "organism": "Zebrafish", "refseq_name": "regulating synaptic membrane exocytosis protein 3 isoform X1", "refseq_ac": "XP_005170109", "gene_names_uniprotkb": "rims3; si:ch211-239d6.1", "gene_names_refseq": "rims3; si:ch211-239d6.1", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 3 isoform X1", "protein_names_refseq": "regulating synaptic membrane exocytosis protein 3 isoform X1", "tax_id": 7955, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dre:563414)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20463905;27189481;28252024;29422031;35377459", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133194) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BHF8", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0098882 structural constituent of presynaptic active zone", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0006887 exocytosis;GO:0016082 synaptic vesicle priming;GO:0016081 synaptic vesicle docking;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A5PMY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A5PMI2-1", "uniprot_id": "A5PMI2_DANRE", "mass": 132744.0, "length": 1216, "protein_name": "Zinc finger FYVE domain-containing protein 9 isoform X1", "gene_name": "zfyve9a", "organism": "Zebrafish", "refseq_name": "zinc finger FYVE domain-containing protein 9 isoform X1", "refseq_ac": "XP_005171254", "gene_names_uniprotkb": "zfyve9a", "gene_names_refseq": "zfyve9a", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 9 isoform X1", "protein_names_refseq": "zinc finger FYVE domain-containing protein 9 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:100005449); (R-DRE-2173789)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133177) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M2BIH3;F1RDB3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005545 1-phosphatidylinositol binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0001889 liver development;GO:0048699 generation of neurons;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PMI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B0S5B4-1", "uniprot_id": "B0S5B4_DANRE", "mass": 120662.0, "length": 1076, "protein_name": "StAR-related lipid transfer protein 8", "gene_name": "stard8", "organism": "Zebrafish", "refseq_name": "stAR-related lipid transfer protein 8", "refseq_ac": "NP_001119949", "gene_names_uniprotkb": "stard8; fj78h09; si:ch211-124k10.2; wu:fj78h09", "gene_names_refseq": "fj78h09; si:ch211-124k10.2; stard8; wu:fj78h09", "protein_names_uniprotkb": "StAR-related lipid transfer protein 8", "protein_names_refseq": "StAR-related lipid transfer (START) domain containing 8; stAR-related lipid transfer protein 8", "tax_id": 7955, "disease": "gonadal dysgenesis (Disease Ontology:DOID:14447)", "pathway": " (dre:558476); (R-DRE-8980692); (R-DRE-9013026); (R-DRE-9013148)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15520368;28789986;31295059;31399345", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GFIL01039946.1, BC133138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476730, SAMEA4476738 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JBMGRA010000005.1. On May 15, 2009 this sequence version replaced NP_001076286.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1NJF9", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0030036 actin cytoskeleton organization;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0S5B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8JHR9-1", "uniprot_id": "B8JHR9_DANRE", "mass": 122739.0, "length": 1093, "protein_name": "Importin-5", "gene_name": "kpnb3", "organism": "Zebrafish", "refseq_name": "importin-5 isoform X1", "refseq_ac": "XP_009303669", "gene_names_uniprotkb": "kpnb3; cb273; fc38a10; wu:fc38a10", "gene_names_refseq": "cb273; fc38a10; kpnb3; wu:fc38a10", "protein_names_uniprotkb": "Importin-5; Importin subunit beta-3; Karyopherin beta-3; Ran-binding protein 5", "protein_names_refseq": "importin-5 isoform X1", "tax_id": 7955, "disease": "", "pathway": " (dre:569455)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26469318;28252024;40044042", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M3AWW3", "ec_number_list": "", "go_molecular_function": "GO:0061608 nuclear import signal receptor activity;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B8JHR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8A5M0-1", "uniprot_id": "B8A5M0_DANRE", "mass": 35547.0, "length": 301, "protein_name": "RING finger protein 175 isoform 2", "gene_name": "rnf175", "organism": "Zebrafish", "refseq_name": "RING finger protein 175 isoform 2", "refseq_ac": "NP_956602", "gene_names_uniprotkb": "rnf175; zgc:56665", "gene_names_refseq": "rnf175; zgc:56665", "protein_names_uniprotkb": "RING finger protein 175 isoform 2", "protein_names_refseq": "DKEYP-75B4.3; RING finger protein 175 isoform 2", "tax_id": 7955, "disease": "", "pathway": " (dre:393278)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12477932;21873635;26469318", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BC050174.1, GFIL01032876.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505375 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000001.1. On or before Jun 12, 2016 this sequence version replaced XP_005170907.1, NP_956602.1. Transcript Variant: This variant (2) contains an alternate exon, resulting in the use of a downstream translational start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8M1PH01", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016020 membrane;GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B8A5M0-1", "record_type": "protein" } ]