[ { "uniprot_canonical_ac": "A0A663DJA2-1", "uniprot_id": "ORF10_SARS2", "mass": 4449.0, "length": 38, "protein_name": "Putative ORF10 protein", "gene_name": "ORF10", "organism": "SARS-CoV-2", "refseq_name": "ORF10 protein", "refseq_ac": "YP_009725255", "gene_names_uniprotkb": "ORF10", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative ORF10 protein", "protein_names_refseq": "ORF10 protein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 41, "publication_id_list": "32015508;32160149;32229288;32315281;32342724;32357959;32366488;32376603;32408337;32422201;32436571;32459984;32499358;32543353;32707573;32854108;32943628;32949774;32999467;33022950;33031744;33051368;33082293;33248470;33301543;33317424;33350913;33439885;33501730;33568452;33605978;33630831;33632859;33643227;33675655;33722935;33770098;33911008;34793243;35636250;38605956", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "A0A663DJA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC1-1", "uniprot_id": "R1A_SARS2", "mass": 489989.0, "length": 4405, "protein_name": "Replicase polyprotein 1a", "gene_name": "", "organism": "SARS-CoV-2", "refseq_name": "ORF1a polyprotein", "refseq_ac": "YP_009725295", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Replicase polyprotein 1a; 2.7.7.50; GFL; Growth factor-like peptide; Leader protein; Main protease; Mpro; Non-structural protein 1; Non-structural protein 3; Non-structural protein 5; Non-structural protein 9; ORF1a polyprotein; PL-PRO; PL2-PRO; Papain-like proteinase; SARS coronavirus main proteinase; nsp1; nsp3; nsp5; nsp9; p65 homolog; pp1a", "protein_names_refseq": "ORF1a polyprotein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 49, "publication_id_list": "32015508;32198291;32272481;32277040;32321856;32358203;32438371;32526208;32578982;32680882;32726803;32733001;32763915;32908316;32946224;32979938;33080218;33232691;33413740;33479166;33727702;34171305;34210785;34506741;34562452;34729465;35044811;35383307;35389886;35484232;35551511;35594856;35750048;35878012;35944563;36254196;36534661;37073102;37242344;38605956;38608022;38781962;38814682;38932408;39223933;39284068;39773525;40118151;41289387", "class_list": "", "function": "Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs (PubMed:35944563). The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate (PubMed:35944563). Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA (PubMed:35944563). The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures (PubMed:35944563). Interacts with ribosome signal recognition particle RNA (SRP) (PubMed:33080218). Together with NSP8, suppress protein integration into the cell membrane, thereby disrupting host immune defenses (PubMed:33080218)., [UniProtKB, PubMed, PubMed]; Cleaves the C-terminus of replicase polyprotein at 11 sites (PubMed:32321856). Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN] (PubMed:32198291, PubMed:32272481). Cleaves and inactivates human TRMT1, preventing tRNA guanine(26)-dimethylation of tRNAs (PubMed:37073102, PubMed:38814682, PubMed:39773525). May cleave human NLRP1 in lung epithelial cells, thereby activating the NLRP1 inflammasome pathway (PubMed:35594856). May cleave human GSDMD, triggering alternative GSDME-mediated epithelial cell death upon activation of the NLRP1 inflammasome, which may enhance the release interleukins 1B, 6, 16 and 18 (PubMed:35594856). Also able to bind an ADP-ribose-1''-phosphate (ADRP) (PubMed:32198291, PubMed:32272481). Cleaves host STIM1 producing two functional fragments: STIM1 N-terminus, which inhibits MAVS-mediated IFNB signaling by disrupting signalosome formation, and STIM1 C-terminus, which suppresses p65-driven IFNB transcription (PubMed:41289387). Inhibits host pyroptosis through the cleavage of host gasdermin D/GSDMD (PubMed:40118151)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Enhances mRNA repression of the 4EHP-GYF2 complex in the host, thereby inhibiting the antiviral response and facilitating SARS-CoV-2 replication. Possibly acts in cooperation with nsp1, which induces ribosome stalling on host mRNA, triggering mRNA repression by the host 4EHP-GYF2 complex which is enhanced by nsp2., [UniProtKB, PubMed]; Inhibits host translation by associating with the open head conformation of the 40S subunit (PubMed:32680882, PubMed:32908316, PubMed:33080218, PubMed:33479166). The C-terminus binds to and obstructs ribosomal mRNA entry tunnel (PubMed:32680882, PubMed:32908316, PubMed:33080218, PubMed:33479166). Thereby inhibits antiviral response triggered by innate immunity or interferons (PubMed:32680882, PubMed:32979938, PubMed:33080218). The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation (By similarity). This inhibits the integrated stress response (ISR) in the infected cell by preventing EIF2S1/eIF2-alpha phosphorylation upstream of stress granule formation and depletes host G3BP1 (PubMed:36534661). Viral mRNAs less susceptible to nsp1-mediated inhibition of translation, because of their 5'-end leader sequence (PubMed:32908316, PubMed:33080218)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein., [UniProtKB, UniProtKB]; Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease (By similarity) and nsp16 2'-O-methyltransferase activities (PubMed:35944563). Therefore plays an essential role in viral mRNAs cap methylation., [UniProtKB, UniProtKB, PubMed]; Plays a role in the formation and maintenance of double membrane vesicles (DMVs) replication organelles (PubMed:35551511). DMVs are formed by nsp3 and nsp4, while nsp6 zippers ER membranes and connects to lipid droplets (LDs) (PubMed:35551511). LDs are consumed during DMV formation (PubMed:35551511). Binds to host TBK1 without affecting TBK1 phosphorylation; the interaction with TBK1 decreases IRF3 phosphorylation, which leads to reduced IFN-beta production (PubMed:32979938)., [UniProtKB, PubMed, PubMed]; Plays a role in viral RNA synthesis (PubMed:32277040, PubMed:32358203, PubMed:32438371, PubMed:32526208). Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers (By similarity). Interacts with ribosome signal recognition particle RNA (SRP) (PubMed:33080218). Together with NSP9, suppress protein integration into the cell membrane, thereby disrupting host immune defenses (PubMed:33080218)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Responsible for the cleavages located at the N-terminus of the replicase polyprotein. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication (PubMed:35551511). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:32733001). Also prevents host NF-kappa-B signaling (By similarity). In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:32726803). Cleaves preferentially ISG15 from antiviral protein IFIH1 (MDA5), but not RIGI (PubMed:33727702). Contains an ADP-ribose hydrolase activity that binds ADP-ribose and catalyzes the removal of mono-ADP-ribose (de-MARylation), usually bound to a glutamate or aspartate (Probable) (PubMed:37242344). ADP-ribose hydrolase activity allows the virus to interfere with the host immune defenses involving poly-ADP-ribose polymerases (PARPs) (Probable). Plays a role in the formation and maintenance of double membrane vesicles (DMVs) replication organelles (PubMed:35551511). DMVs are formed by nsp3 and nsp4, while nsp6 zippers ER membranes and connects to lipid droplets (PubMed:35551511)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008242 omega peptidase activity;GO:0008270 zinc ion binding;GO:0008289 lipid binding;GO:0003727 single-stranded RNA binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0042025 host cell nucleus;GO:0044220 host cell perinuclear region of cytoplasm;GO:0044167 host cell endoplasmic reticulum membrane;GO:0044177 host cell Golgi apparatus;GO:0044174 host cell endosome", "go_biological_process": "GO:0019082 viral protein processing;GO:0006508 proteolysis;GO:0019079 viral genome replication;GO:0032259 methylation;GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P0DTC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC2-1", "uniprot_id": "SPIKE_SARS2", "mass": 141178.0, "length": 1273, "protein_name": "Spike glycoprotein", "gene_name": "S", "organism": "SARS-CoV-2", "refseq_name": "surface glycoprotein", "refseq_ac": "YP_009724390", "gene_names_uniprotkb": "S; 2", "gene_names_refseq": "", "protein_names_uniprotkb": "Spike glycoprotein; E2; Peplomer protein; S glycoprotein", "protein_names_refseq": "surface glycoprotein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 239, "publication_id_list": "10.1016/j.celrep.2021.109179;10.1021/acs.analchem.0c03301;10.1074/mcp.RA120.002295;10.1101/2020.03.28.013276;10.1101/2020.03.28.013276v2;10.1101/2020.04.01.020966;10.1126/science.abb9983;10.3390/v13040551;32015508;32075877;32132184;32142651;32155444;32221306;32225175;32225176;32245784;32362314;32363391;32366695;32518941;32577644;32676595;32697968;32703818;32730807;32732280;32791978;32817270;32820179;32913053;32929138;32979941;32979942;32989130;32999467;33064451;33077685;33082293;33082294;33102950;33106671;33134398;33140034;33184236;33184509;33220791;33229438;33325143;33338412;33406838;33413740;33417835;33427749;33443248;33465165;33495758;33607086;33619492;33636719;33646265;33664060;33690265;33709491;33744048;33789084;33806155;33810465;33853928;33871970;33888467;33890550;33911008;33923363;33972535;33981021;34004174;34006597;34044428;34061349;34086357;34098342;34108961;34159616;34162945;34166617;34171266;34171305;34208032;34210785;34210893;34222571;34231935;34249101;34273512;34320609;34322129;34329696;34369795;34384783;34413500;34465633;34504087;34506741;34514088;34538222;34561887;34592572;34599882;34621266;34627082;34630356;34631661;34639178;34647971;34650130;34670086;34672530;34684763;34704808;34725257;34728796;34729465;34732583;34756082;34793243;34805136;34814158;34837059;34857854;34869209;34903715;34950151;34968416;35013235;35026152;35061630;35078277;35102342;35104433;35108439;35116022;35126971;35139340;35150743;35154095;35157735;35171086;35174857;35181310;35196796;35290246;35297693;35314848;35371042;35383307;35389886;35404959;35411021;35474581;35475171;35484232;35486722;35561224;35575289;35675811;35699447;35723978;35737812;35750048;35803932;35857584;35857619;35891550;35916768;35937077;35957961;36068240;36134660;36138301;36149962;36195474;36254196;36302758;36320702;36329138;36408799;36494499;36508877;36526616;36550570;36603583;36646780;36658749;36680141;36685521;36691733;36701425;36735681;36779763;36806685;36851165;36851546;36912367;36969239;37036004;37193826;37251407;37275886;37390223;37421949;37468623;37541134;37596280;37766081;37798298;37809871;37886945;38036525;38045681;38077128;38105139;38117652;38214610;38236134;38257752;38458195;38539271;38605956;38608022;38716629;38781962;38866784;38885041;38932408;39002680;39284068;39456150;39589869", "class_list": "", "function": "Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2 (PubMed:32142651, PubMed:32155444, PubMed:33607086). When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane (PubMed:34561887). When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane (PubMed:32075877, PubMed:32221306, PubMed:34903715, PubMed:36779763). Alternatively, may use NRP1/NRP2 (PubMed:33082294, PubMed:33082293) and integrin as entry receptors (PubMed:35150743). The use of NRP1/NRP2 receptors may explain the tropism of the virus in human olfactory epithelial cells, which express these molecules at high levels but ACE2 at low levels (PubMed:33082293). Uses also ASGR1 as an alternative receptor in an ACE2-independent manner (PubMed:34837059). The stalk domain of S contains three hinges, giving the head unexpected orientational freedom (PubMed:32817270)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Precursor of the fusion protein processed in the biosynthesis of the S protein and the formation of virus particle. Mediates fusion of the virion and cellular membranes by functioning as a class I viral fusion protein. Contains two viral fusion peptides that are unmasked after cleavage. The S2/S2' cleavage occurs during virus entry at the cell membrane by host TMPRSS2 (PubMed:32142651) or during endocytosis by host CSTL (PubMed:32703818, PubMed:34159616). In either case, this triggers an extensive and irreversible conformational change leading to fusion of the viral envelope with the cellular cytoplasmic membrane, releasing viral genomic RNA into the host cell cytoplasm (PubMed:34561887). Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During fusion of the viral and target cell membranes, the coiled coil regions (heptad repeats) adopt a trimer-of-hairpins structure and position the fusion peptide in close proximity to the C-terminal region of the ectodomain. Formation of this structure appears to promote apposition and subsequent fusion of viral and target cell membranes., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]; Subunit of the fusion protein that is processed upon entry into the host cell. Mediates fusion of the virion and cellular membranes by functioning as a class I viral fusion protein. Contains a viral fusion peptide that is unmasked after S2 cleavage. This cleavage can occur at the cell membrane by host TMPRSS2 or during endocytosis by host CSTL (PubMed:32703818, PubMed:34159616). In either case, this triggers an extensive and irreversible conformational change that leads to fusion of the viral envelope with the cellular cytoplasmic membrane, releasing viral genomic RNA into the host cell cytoplasm (PubMed:34561887). Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During fusion of the viral and target cell membranes, the coiled coil regions (heptad repeats) adopt a trimer-of-hairpins structure and position the fusion peptide in close proximity to the C-terminal region of the ectodomain. Formation of this structure appears to promote apposition and subsequent fusion of viral and target cell membranes., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 27, "mined_n_glycosites": 19, "mined_o_glycosites": 8, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 38, "reported_o_glycosites": 6, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 25, "reported_o_glycosites_with_glycan": 31, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 39, "total_reported_o_glycosites": 32, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 42, "total_o_glycosites": 36, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 23, "reported_phosphosites": 0, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 396, "disease_count": 1, "glyco_site_count": 76, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0048018 receptor ligand activity;GO:0046789 host cell surface receptor binding;GO:0039660 structural constituent of virion", "go_cellular_component": "GO:0044228 host cell surface;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0019031 viral envelope;GO:0055036 virion membrane", "go_biological_process": "GO:0046598 positive regulation of viral entry into host cell;GO:0046718 symbiont entry into host cell;GO:0046813 receptor-mediated virion attachment to host cell;GO:0061025 membrane fusion;GO:0019064 fusion of virus membrane with host plasma membrane", "synthesized_glycan_count": 0, "hit_score": 70.7, "record_id": "P0DTC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC3-1", "uniprot_id": "AP3A_SARS2", "mass": 31123.0, "length": 275, "protein_name": "ORF3a protein", "gene_name": "3a", "organism": "SARS-CoV-2", "refseq_name": "ORF3a protein", "refseq_ac": "YP_009724391", "gene_names_uniprotkb": "3a", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF3a protein; Accessory protein 3a; ORF3a; Protein 3a; Protein U274; Protein X1", "protein_names_refseq": "ORF3a protein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 34, "publication_id_list": "32015508;32999467;33128877;33157038;33184509;33422265;33427749;33853928;33972535;34158638;34506741;34627082;34729465;34793243;34968416;35104433;35108439;35157735;35196796;35239449;35383307;35389886;35484232;36134660;36254196;36302758;36494499;36526616;36603583;36969239;38045681;38077128;38387105;38932408", "class_list": "", "function": "Plays a role in viral egress via lysosomal trafficking (PubMed:33157038, PubMed:33422265). Forms homotetrameric ion channels (viroporins) localized at endosomes and lysosomes, that may induce deacidification of lysosomes, allowing safe egress of virions via lysosomal trafficking (PubMed:33157038, PubMed:33422265, PubMed:34158638). Also blocks autolysosome formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS) on late endosomes (PubMed:33422265). This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress (PubMed:33422265). Induces host RETREG1/FAM134B-dependent reticulophagy by interacting with host HMGB1 and enhancing the association between HMGB1 and host BECN1 (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0055036 virion membrane;GO:0020002 host cell plasma membrane", "go_biological_process": "GO:0140883 symbiont-mediated activation of host reticulophagy", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P0DTC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC4-1", "uniprot_id": "VEMP_SARS2", "mass": 8365.0, "length": 75, "protein_name": "Envelope small membrane protein", "gene_name": "E", "organism": "SARS-CoV-2", "refseq_name": "envelope protein", "refseq_ac": "YP_009724392", "gene_names_uniprotkb": "E; 4", "gene_names_refseq": "", "protein_names_uniprotkb": "Envelope small membrane protein; E; sM protein", "protein_names_refseq": "envelope protein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 25, "publication_id_list": "32015508;32791978;32891874;32898469;32999467;33177698;33229438;33853928;33911008;34166618;34231935;34249101;34529740;34728796;34793243;34814158;35108439;35283834;35937077;37596280;37766081;38045681;38605956;38608022;39598409", "class_list": "", "function": "Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by slowing down the cell secretory pathway (PubMed:33229438). May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes (PubMed:32891874)., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0055036 virion membrane;GO:0044178 host cell Golgi membrane", "go_biological_process": "GO:0046760 viral budding from Golgi membrane;GO:0140975 disruption of cellular anatomical structure in another organism;GO:0052025 symbiont-mediated perturbation of host cell endomembrane system", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P0DTC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC5-1", "uniprot_id": "VME1_SARS2", "mass": 25147.0, "length": 222, "protein_name": "Membrane protein", "gene_name": "M", "organism": "SARS-CoV-2", "refseq_name": "membrane glycoprotein", "refseq_ac": "YP_009724393", "gene_names_uniprotkb": "M", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane protein; E1 glycoprotein; Matrix glycoprotein; Membrane glycoprotein; M", "protein_names_refseq": "membrane glycoprotein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 55, "publication_id_list": "32015508;32791978;32913053;32999467;33128877;33229438;33664060;33853928;33911008;33972535;34086357;34145459;34171305;34210785;34231935;34249101;34312620;34529740;34609506;34696201;34725257;34728796;34793243;34814158;34968416;35104433;35157735;35383307;35389886;35484232;35486722;35699447;35931673;35937077;36254196;36264056;36494499;36526616;36603583;36646780;37468623;37596280;37766081;38105139;38117652;38214610;38387105;38605956;38608022;38666819;38781962;38866784;38932408;39066169;39598409", "class_list": "", "function": "Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins (By similarity). Regulates the localization of S protein at cis-Golgi, the place of virus budding (PubMed:33229438). May act by binding cytoplasmic c-terminus of S (PubMed:33229438)., [UniProtKB, HAMAP, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0039660 structural constituent of virion;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0019031 viral envelope;GO:0055036 virion membrane;GO:0044178 host cell Golgi membrane", "go_biological_process": "GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P0DTC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC6-1", "uniprot_id": "NS6_SARS2", "mass": 7273.0, "length": 61, "protein_name": "ORF6 protein", "gene_name": "6", "organism": "SARS-CoV-2", "refseq_name": "ORF6 protein", "refseq_ac": "YP_009724394", "gene_names_uniprotkb": "6", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF6 protein; Accessory protein 6; Non-structural protein 6; ORF6; Protein X3; ns6", "protein_names_refseq": "ORF6 protein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 17, "publication_id_list": "32015508;32979938;32999467;33097660;33360543;33849972;33853928;33911008;34145459;34506741;34793243;35096974;35187564;35389886;36254196;38117652;38605956", "class_list": "", "function": "Disrupts bidirectional nucleocytoplasmic transport by interacting with the host RAE1-NUP98 complex (PubMed:33360543, PubMed:33849972). Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:32979938). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (By similarity). Prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:33097660). Suppresses IFN-beta production possibly by blocking IRF3 nuclear translocation (PubMed:32979938). Might induce accumulation of host HNRNPA1 (PubMed:33360543)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; May play a role in viral double membrane vesicles networks to enhance viral replication., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005643 nuclear pore;GO:0044178 host cell Golgi membrane;GO:0044167 host cell endoplasmic reticulum membrane", "go_biological_process": "GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway;GO:0039563 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity;GO:0039564 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity;GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity;GO:0039579 symbiont-mediated suppression of host ISG15-protein conjugation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0DTC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC7-1", "uniprot_id": "NS7A_SARS2", "mass": 13744.0, "length": 121, "protein_name": "ORF7a protein", "gene_name": "7a", "organism": "SARS-CoV-2", "refseq_name": "ORF7a protein", "refseq_ac": "YP_009724395", "gene_names_uniprotkb": "7a", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF7a protein; Accessory protein 7a; ORF7a; Protein U122; Protein X4", "protein_names_refseq": "ORF7a protein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 19, "publication_id_list": "32015508;32999467;33413740;33427749;33473190;33615195;33853928;33911008;33930332;34171305;34793243;35108439;35389886;35484232;36494499;36574644;36618358;38105139;38605956", "class_list": "", "function": "Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect (PubMed:33930332). Acts by binding to BST2 and sequestering it to perinuclear region, thereby preventing its antiviral function at cell membrane (PubMed:33930332). May specifically downregulate MHC-I allele HLA-A*02:01 (HLA-A2) (PubMed:36574644)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0044220 host cell perinuclear region of cytoplasm;GO:0055036 virion membrane;GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0044178 host cell Golgi membrane;GO:0044167 host cell endoplasmic reticulum membrane", "go_biological_process": "GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity;GO:0039646 symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint;GO:0046776 symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I;GO:0052170 symbiont-mediated suppression of host innate immune response;GO:0044071 symbiont-mediated perturbation of host cell cycle progression", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P0DTC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC8-1", "uniprot_id": "NS8_SARS2", "mass": 13831.0, "length": 121, "protein_name": "ORF8 protein", "gene_name": "8", "organism": "SARS-CoV-2", "refseq_name": "ORF8 protein", "refseq_ac": "YP_009724396", "gene_names_uniprotkb": "8", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF8 protein; Non-structural protein 8; ORF8; ns8", "protein_names_refseq": "ORF8 protein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 24, "publication_id_list": "31986261;32015508;32615316;32807944;32854725;32999467;33361333;33413740;33723527;33853928;33911008;34003073;34021074;34177923;34506741;34793243;34814158;35104433;35157849;35343786;35857619;36689483;37596280;38605956", "class_list": "", "function": "Plays a role in modulating the host immune response (PubMed:31986261, PubMed:35343786, PubMed:36689483). May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increased secretion of pro-inflammatory factors (PubMed:35343786, PubMed:36689483). Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway (PubMed:33723527, PubMed:36689483). May act by down-regulating major histocompability complex class I (MHC-I) at cell surface (PubMed:34021074, PubMed:35157849). May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 (PubMed:34177923)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome", "go_biological_process": "GO:0032688 negative regulation of interferon-beta production;GO:0002891 positive regulation of immunoglobulin mediated immune response;GO:0052031 symbiont-mediated perturbation of host defense response;GO:0046776 symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I;GO:0141174 symbiont-mediated suppression of host anti-inflammatory cytokine signaling", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P0DTC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTC9-1", "uniprot_id": "NCAP_SARS2", "mass": 45626.0, "length": 419, "protein_name": "Nucleoprotein", "gene_name": "N", "organism": "SARS-CoV-2", "refseq_name": "nucleocapsid phosphoprotein", "refseq_ac": "YP_009724397", "gene_names_uniprotkb": "N", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleoprotein; NC; Nucleocapsid protein; N; Protein N", "protein_names_refseq": "nucleocapsid phosphoprotein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 96, "publication_id_list": "32015508;32363136;32654247;32668444;32791978;32887977;32913053;32974389;32979941;32994364;32999467;33128877;33184509;33264373;33413740;33427749;33495758;33521593;33664060;33723016;33772767;33853928;33911008;33923363;33945786;33995351;34061349;34070152;34171305;34210785;34222571;34249101;34341353;34389625;34529740;34593624;34609506;34611361;34627082;34630356;34728796;34793243;34814158;34853448;34901782;34968416;35037999;35044811;35104433;35157735;35196796;35328398;35389886;35484232;35486722;35699447;35728038;35750048;35857584;35921414;35922005;35937077;36134660;36151076;36238992;36254196;36494499;36534661;36603583;36646780;37036004;37112903;37275518;37471227;37596280;37766081;37872153;37898784;38077128;38105139;38117652;38172120;38214610;38387105;38539271;38605956;38608022;38781962;38866784;38932408;39135075;39225180;39284068;39418521;39496850;39591116", "class_list": "", "function": "May block host chemokine function in vivo, facilitating viral replication and transmission (PubMed:35921414). Acts by being secreted into the extracellular space where it competes to host chemokines for binding to host glycosaminoglycans (GAG) (PubMed:35921414)., [UniProtKB, PubMed]; May induce inflammasome responses in cultured cells and mice. Acts by interacting with host NLRP3 to facilitate inflammasome assembly, which induces cytokine release that may play a role in COVID lung injury. Disrupts the association betwen NLRP3 and ABHD8, enhancing NLRP3 stability and leading to increased inflammasome activation (PubMed:39225180)., [UniProtKB, PubMed, PubMed]; Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M (PubMed:33264373). Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Attenuates the stress granules formation by reducing host G3BP1 access to host mRNAs under stress conditions (PubMed:34901782, PubMed:36534661)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0042288 MHC class I protein binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0042612 MHC class I protein complex;GO:1990904 ribonucleoprotein complex;GO:0019028 viral capsid", "go_biological_process": "GO:0019074 viral RNA genome packaging;GO:0006351 DNA-templated transcription;GO:0032688 negative regulation of interferon-beta production;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly;GO:0052572 response to host immune response", "synthesized_glycan_count": 0, "hit_score": 9.7, "record_id": "P0DTC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTD1-1", "uniprot_id": "R1AB_SARS2", "mass": 794058.0, "length": 7096, "protein_name": "Replicase polyprotein 1ab", "gene_name": "rep", "organism": "SARS-CoV-2", "refseq_name": "ORF1ab polyprotein", "refseq_ac": "YP_009724389", "gene_names_uniprotkb": "rep; 1a-1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Replicase polyprotein 1ab; ExoN; GFL; Growth factor-like peptide; Leader protein; Main protease; Mpro; NendoU; Non-structural protein 12; Non-structural protein 13; Non-structural protein 14; Non-structural protein 15; Non-structural protein 16; Non-structural protein 1; Non-structural protein 3; Non-structural protein 5; Non-structural protein 9; ORF1ab polyprotein; PL-PRO; PL2-PRO; Papain-like proteinase; Proofreading exoribonuclease nsp14; RNA-capping enzyme subunit nsp9; SARS coronavirus main proteinase; nsp12; nsp13; nsp14; nsp15; nsp16; nsp1; nsp3; nsp5; nsp9; p65 homolog; pp1ab", "protein_names_refseq": "ORF1ab polyprotein", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 95, "publication_id_list": "32015508;32198291;32272481;32277040;32321856;32358203;32438371;32526208;32578982;32668444;32680882;32726803;32733001;32763915;32791978;32908316;32913053;32979938;32999467;33080218;33128877;33184509;33232691;33413740;33427749;33479166;33504779;33564093;33713597;33727702;33853928;33911008;33972535;34145459;34171305;34210785;34312620;34506741;34562452;34627082;34725257;34728796;34758478;34793243;34919800;34968416;35044811;35074422;35104433;35108439;35196796;35383307;35389886;35484232;35551511;35594856;35699447;35706445;35878012;35937077;35944563;36151076;36201943;36254196;36285486;36494499;36526616;36534661;36546776;36603583;36691482;36722972;37036004;37073102;37193826;37215095;37242344;37390223;37766081;37794589;38045681;38117652;38124752;38214610;38387105;38605956;38781962;38814682;38932408;39223933;39456150;39589869;39773525;40118151;41289387", "class_list": "", "function": "Cleaves the C-terminus of replicase polyprotein at 11 sites (PubMed:32321856). Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN] (PubMed:32198291, PubMed:32272481). Cleaves and inactivates human TRMT1, preventing tRNA guanine(26)-dimethylation of tRNAs (PubMed:37073102, PubMed:38814682, PubMed:39773525). May cleave human NLRP1 in lung epithelial cells, thereby activating the NLRP1 inflammasome pathway (PubMed:35594856). May cleave human GSDMD, triggering alternative GSDME-mediated epithelial cell death upon activation of the NLRP1 inflammasome, which may enhance the release interleukins 1B, 6, 16 and 18 (PubMed:35594856). Also able to bind an ADP-ribose-1''-phosphate (ADRP) (PubMed:32198291, PubMed:32272481). Cleaves host STIM1 producing two functional fragments: STIM1 N-terminus, which inhibits MAVS-mediated IFNB signaling by disrupting signalosome formation, and STIM1 C-terminus, which suppresses p65-driven IFNB transcription (PubMed:41289387). Inhibits host pyroptosis through the cleavage of host gasdermin D/GSDMD (PubMed:40118151)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Enhances mRNA repression of the 4EHP-GYF2 complex in the host, thereby inhibiting the antiviral response and facilitating SARS-CoV-2 replication. Possibly acts in cooperation with nsp1, which induces ribosome stalling on host mRNA, triggering mRNA repression by the host 4EHP-GYF2 complex which is enhanced by nsp2., [UniProtKB, PubMed]; Forms a primer, NSP9-pU, which is utilized by the polymerase for the initiation of RNA chains (PubMed:37794589). Interacts with ribosome signal recognition particle RNA (SRP) (PubMed:33080218). Together with NSP8, suppress protein integration into the cell membrane, thereby disrupting host immune defenses (PubMed:33080218)., [UniProtKB, PubMed, PubMed, PubMed]; Inhibits host translation by associating with the open head conformation of the 40S subunit (PubMed:32680882, PubMed:32908316, PubMed:33080218, PubMed:33479166). The C-terminus binds to and obstructs ribosomal mRNA entry tunnel (PubMed:32680882, PubMed:32908316, PubMed:33080218, PubMed:33479166). Thereby inhibits antiviral response triggered by innate immunity or interferons (PubMed:32680882, PubMed:32979938, PubMed:33080218). The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation (By similarity). This inhibits the integrated stress response (ISR) in the infected cell by preventing EIF2S1/eIF2-alpha phosphorylation upstream of stress granule formation and depletes host G3BP1 (PubMed:36534661). Viral mRNAs less susceptible to nsp1-mediated inhibition of translation, because of their 5'-end leader sequence (PubMed:32908316, PubMed:33080218)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs (PubMed:35944563). N7-methyl guanosine cap is a prerequisite for binding of nsp16 (PubMed:35944563). Therefore, it plays an essential role in cap methylation of viral mRNAs, which is essential to evade the immune system, especially when restricted by human IFIT1 and IFIT3 (PubMed:35944563, PubMed:36722972, PubMed:36285486). May disrupt host mRNA splicing in nucleus by interacting with pre-mRNA Recognition Domains of the U1 and U2 snRNAs (PubMed:33080218)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein., [UniProtKB, UniProtKB]; Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease (By similarity) and nsp16 2'-O-methyltransferase activities (PubMed:35944563). Therefore plays an essential role in viral mRNAs cap methylation., [UniProtKB, UniProtKB, PubMed]; Plays a role in the formation and maintenance of double membrane vesicles (DMVs) replication organelles (PubMed:35551511). DMVs are formed by nsp3 and nsp4, while nsp6 zippers ER membranes and connects to lipid droplets (PubMed:35551511). LDs are consumed during DMV formation (PubMed:35551511). Binds to host TBK1 without affecting TBK1 phosphorylation; the interaction with TBK1 decreases IRF3 phosphorylation, which leads to reduced IFN-beta production (PubMed:32979938)., [UniProtKB, PubMed, PubMed]; Plays a role in viral RNA synthesis (PubMed:32277040, PubMed:32358203, PubMed:32438371, PubMed:32526208). Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Plays a role in viral RNA synthesis (PubMed:33232691). Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium (By similarity). Binds to host TBK1 and inhibits TBK1 phosphorylation; the interaction with TBK1 decreases IRF3 phosphorylation, which leads to reduced IFN-beta production (PubMed:32979938)., [UniProtKB, UniProtKB, PubMed, PubMed]; Plays a role in viral RNA synthesis through two distinct activities. The N7-guanine methyltransferase activity plays a role in the formation of the cap structure GpppA-RNA (PubMed:35944563). The proofreading exoribonuclease reduces the sensitivity of the virus to RNA mutagens during replication (By similarity). This activity acts on both ssRNA and dsRNA in a 3'-5' direction (By similarity)., [UniProtKB, UniProtKB, PubMed]; Plays a role in viral transcription/replication and prevents the simultaneous activation of host cell dsRNA sensors, such as MDA5/IFIH1, OAS, and PKR (By similarity). Acts by degrading the 5'-polyuridines generated during replication of the poly(A) region of viral genomic and subgenomic RNAs (PubMed:33504779, PubMed:33564093). Catalyzes a two-step reaction in which a 2'3'-cyclic phosphate (2'3'-cP) is first generated by 2'-O transesterification, which is then hydrolyzed to a 3'-phosphate (3'-P) (PubMed:33504779, PubMed:33564093). If not degraded, poly(U) RNA would hybridize with poly(A) RNA tails and activate host dsRNA sensors (By similarity). May bind genomic dsRNA in association with the replication-transcription complex (RTC), and play a role in nsp12 discontinous transcription (PubMed:34562452, PubMed:35706445)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; RNA-directed RNA polymerase that catalyzes the transcription of viral genomic and subgenomic RNAs. Acts in complex with nsp7 and nsp8 to transcribe both the minus and positive strands of genomic RNA (PubMed:32277040, PubMed:32358203, PubMed:32438371, PubMed:32526208). The kinase-like NiRAN domain of NSP12 attaches one or more nucleotides to the amino terminus of NSP9, forming a covalent RNA-protein intermediate that serves as transcription/replication primer (PubMed:37794589). Subgenomic RNAs (sgRNAs) are formed by discontinuous transcription: The polymerase has the ability to pause at transcription-regulating sequences (TRS) and jump to the leader TRS, resulting in a major deletion (PubMed:35706445). This creates a series of subgenomic RNAs that are replicated, transcribed and translated (PubMed:35706445). In addition, Nsp12 is a subunit of the viral RNA capping enzyme that catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs (PubMed:35944563). Subsequently, the NiRAN domain transfers RNA to GDP, and forms the core cap structure GpppA-RNA (PubMed:35944563)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Responsible for the cleavages located at the N-terminus of the replicase polyprotein. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication (PubMed:35551511). Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3 (PubMed:32733001). Also prevents host NF-kappa-B signaling (By similarity). In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates (PubMed:32726803). Cleaves preferentially ISG15 from antiviral protein IFIH1 (MDA5), but not RIGI (PubMed:33727702). Contains an ADP-ribose hydrolase activity that binds ADP-ribose and catalyzes the removal of mono-ADP-ribose (de-MARylation), usually bound to a glutamate or aspartate (Probable) (PubMed:37242344). ADP-ribose hydrolase activity allows the virus to interfere with the host immune defenses involving poly-ADP-ribose polymerases (PARPs) (Probable). Plays a role in the formation and maintenance of double membrane vesicles (DMVs) replication organelles (PubMed:35551511). DMVs are formed by nsp3 and nsp4, while nsp6 zippers ER membranes and connects to lipid droplets (PubMed:35551511)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 30, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0003968 RNA-directed RNA polymerase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008242 omega peptidase activity", "go_cellular_component": "GO:0042025 host cell nucleus;GO:0044220 host cell perinuclear region of cytoplasm;GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment;GO:0044167 host cell endoplasmic reticulum membrane;GO:0044177 host cell Golgi apparatus", "go_biological_process": "GO:0019082 viral protein processing;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway;GO:0039520 symbiont-mediated activation of host autophagy", "synthesized_glycan_count": 0, "hit_score": 9.6, "record_id": "P0DTD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTD2-1", "uniprot_id": "ORF9B_SARS2", "mass": 10797.0, "length": 97, "protein_name": "ORF9b protein", "gene_name": "9b", "organism": "SARS-CoV-2", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "9b", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF9b protein; Accessory protein 9b; ORF-9b; ORF9b; Protein 9b", "protein_names_refseq": "", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "32015508;32728199;33990585;34166618;34171305;34502139;34793243;38105139", "class_list": "", "function": "Plays a role in inhibiting the host innate immune response by targeting the mitochondrial-associated innate immune response. Acts by binding to host TOMM70, inhibiting its binding to HSP90AB1 thereby disrupting the interferon activation pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0033650 host cell mitochondrion", "go_biological_process": "GO:0090258 negative regulation of mitochondrial fission;GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway;GO:2000786 positive regulation of autophagosome assembly;GO:0050687 negative regulation of defense response to virus;GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P0DTD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTD3-1", "uniprot_id": "ORF9C_SARS2", "mass": 8050.0, "length": 73, "protein_name": "Putative ORF9c protein", "gene_name": "9c", "organism": "SARS-CoV-2", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "9c", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative ORF9c protein; ORF14; ORF9c; Uncharacterized protein 14", "protein_names_refseq": "", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "32015508;32854725;33976134;34793243;35180394", "class_list": "", "function": "May induce apoptosis in cardiomyocytes when overexpressed ex-vivo., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0DTD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTD8-1", "uniprot_id": "NS7B_SARS2", "mass": 5180.0, "length": 43, "protein_name": "ORF7b protein", "gene_name": "7b", "organism": "SARS-CoV-2", "refseq_name": "ORF7b", "refseq_ac": "YP_009725318", "gene_names_uniprotkb": "7b", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF7b protein; Accessory protein 7b; ORF7b", "protein_names_refseq": "ORF7b", "tax_id": 2697049, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "32015508;34793243;38605956", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0044178 host cell Golgi membrane;GO:0044175 host cell endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DTD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTF1-1", "uniprot_id": "ORF3B_SARS2", "mass": 2457.0, "length": 22, "protein_name": "Putative ORF3b protein", "gene_name": "", "organism": "SARS-CoV-2", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative ORF3b protein; ORF3b", "protein_names_refseq": "", "tax_id": 2697049, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "32015508;32807944;32854725;32941788;33976134", "class_list": "", "function": "Acts as an interferon antagonist when expressed ex vivo., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0052170 symbiont-mediated suppression of host innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0DTF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTG0-1", "uniprot_id": "ORF3D_SARS2", "mass": 6482.0, "length": 57, "protein_name": "Putative ORF3d protein", "gene_name": "", "organism": "SARS-CoV-2", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative ORF3d protein", "protein_names_refseq": "", "tax_id": 2697049, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "31987001;32015508;33976134", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DTG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DTG1-1", "uniprot_id": "ORF3C_SARS2", "mass": 4858.0, "length": 41, "protein_name": "ORF3c protein", "gene_name": "", "organism": "SARS-CoV-2", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "ORF3c protein; ORF3c; ORF3h protein; ORF3h", "protein_names_refseq": "", "tax_id": 2697049, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "32015508;32387562;32667280;38117652", "class_list": "", "function": "May play a role in host modulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0DTG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0B7P3V8-1", "uniprot_id": "YP41B_YEAST", "mass": 127189.0, "length": 1104, "protein_name": "Transposon Ty4-P Gag-Pol polyprotein", "gene_name": "TY4B-P", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_001291944", "gene_names_uniprotkb": "TY4B-P; YPLCTy4-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty4-P Gag-Pol polyprotein; TY4A-TY4B; Transposon Ty4 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL060C-A)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16093660;24374639;9169875;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0B7P3V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D6VTK4-1", "uniprot_id": "STE2_YEAST", "mass": 47849.0, "length": 431, "protein_name": "Pheromone alpha factor receptor", "gene_name": "STE2", "organism": "Yeast", "refseq_name": "alpha-factor pheromone receptor STE2", "refseq_ac": "NP_116627", "gene_names_uniprotkb": "STE2", "gene_names_refseq": "STE2", "protein_names_uniprotkb": "Pheromone alpha factor receptor", "protein_names_refseq": "alpha-factor pheromone receptor STE2", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL026W)", "pathway_count": 1, "publication_count": 76, "publication_id_list": "10744981;10866688;10982387;11112532;11287148;11467956;11473349;11495900;11583169;11875433;11994008;12194975;12427030;12624196;1321064;1330324;14506226;15087486;15665377;16313173;16314417;16453635;1647971;1653030;16709573;17287358;17322287;17330950;18407956;19383463;19684113;19779198;19795423;19823750;19828733;2017168;21969566;22106047;22218487;23749301;24374639;2556384;27993568;28073700;2839507;2842059;28958779;3001640;3015412;3023832;3037311;32597660;33268889;33481703;33491328;34433281;34627767;35296853;4595644;6353246;6360378;6993497;7670463;7935439;8132618;8164685;8385135;8392878;8524302;8692892;9286665;9529386;9659916;9742115;9819407;9824658", "class_list": "", "function": "Fungal class D1 G protein-coupled receptor that acts as an alpha-factor pheromone receptor performing pheromone-dependent signal transduction involved in cellular conjugation, mating projection assembly, and in cell fusion (PubMed:10744981, PubMed:11495900, PubMed:12427030, PubMed:2556384, PubMed:2839507, PubMed:2842059, PubMed:3023832, PubMed:3037311, PubMed:4595644, PubMed:6353246, PubMed:6360378, PubMed:6993497, PubMed:9286665, PubMed:9529386, PubMed:9742115, PubMed:9819407, PubMed:9824658). Following alpha-factor-binding, the signal is transmitted via a tripartite G protein consisting of alpha-, beta- and gamma-subunits (GAP1, STE4 and STE8 respectively) that prepares the cell for conjugation (PubMed:10866688, PubMed:11287148, PubMed:1330324, PubMed:1647971, PubMed:8132618, PubMed:8385135, PubMed:8692892). In the inactive state, the cytoplasmic end of transmembrane domain 7 (TMD7) is unstructured and packs between TMD1-6, blocking the G protein coupling site (PubMed:35296853). Agonist binding results in the outward movement of the extracellular ends of TMD6 and TMD7 by 6 Angstroms (PubMed:35296853). On the intracellular surface, the G protein coupling site is formed by a 20 Angstroms outward movement of the unstructured region in TMD7 that unblocks the site, and a 12 Angstroms inward movement of TMD6 (PubMed:35296853)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 33, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P06842;Q70D63;Q70D65;Q70D69;Q70D73;Q70D74", "ec_number_list": "", "go_molecular_function": "GO:0004932 mating-type factor pheromone receptor activity;GO:0004934 mating-type alpha-factor pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0038038 G protein-coupled receptor homodimeric complex", "go_biological_process": "GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion;GO:0000755 cytogamy", "synthesized_glycan_count": 0, "hit_score": 7.9, "record_id": "D6VTK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13297-1", "uniprot_id": "CET1_YEAST", "mass": 61850.0, "length": 549, "protein_name": "mRNA-capping enzyme subunit beta", "gene_name": "CET1", "organism": "Yeast", "refseq_name": "polynucleotide 5'-phosphatase", "refseq_ac": "NP_015096", "gene_names_uniprotkb": "CET1; P1433", "gene_names_refseq": "CES5; CET1", "protein_names_uniprotkb": "mRNA-capping enzyme subunit beta; 3.6.1.74; mRNA 5'-phosphatase; mRNA 5'-triphosphate monophosphatase", "protein_names_refseq": "polynucleotide 5'-phosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL228W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10589681;12788946;14562106;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24909858;3029058;30516470;32597660;33481703;33491328;6094533;6389537;9169875;9345280", "class_list": "", "function": "First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3E2;Q12197", "ec_number_list": "3.6.1.74", "go_molecular_function": "GO:0004651 polynucleotide 5'-phosphatase activity;GO:0140818 mRNA 5'-triphosphate monophosphatase activity", "go_cellular_component": "GO:0031533 mRNA capping enzyme complex", "go_biological_process": "GO:1900182 positive regulation of protein localization to nucleus;GO:0006370 7-methylguanosine mRNA capping;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "O13297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13329-1", "uniprot_id": "FOB1_YEAST", "mass": 65318.0, "length": 566, "protein_name": "DNA replication fork-blocking protein FOB1", "gene_name": "FOB1", "organism": "Yeast", "refseq_name": "replication fork barrier binding protein FOB1", "refseq_ac": "NP_010395", "gene_names_uniprotkb": "FOB1; HRM1; YD9727.06", "gene_names_refseq": "FOB1; HRM1", "protein_names_uniprotkb": "DNA replication fork-blocking protein FOB1", "protein_names_refseq": "replication fork barrier binding protein FOB1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR110W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10230397;14562095;14562106;14645529;18407956;19795423;19823750;22362748;23749301;24374639;32597660;33481703;33491328;33502312;9078378;9169867;9869636", "class_list": "", "function": "Required for replication fork blocking activity at the replication fork barrier (RFB) site in rDNA and for recombination hot-spot (HOT1) activity, regulating the recombination rate and the number of rDNA copies. Binds directly to two separated sequences in the RFB., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS96;Q04587", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043110 rDNA spacer replication fork barrier binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:0006310 DNA recombination;GO:0007059 chromosome segregation;GO:0006325 chromatin organization;GO:0000183 rDNA heterochromatin formation;GO:0043570 maintenance of DNA repeat elements", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O13329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13516-1", "uniprot_id": "RS9A_YEAST", "mass": 22443.0, "length": 197, "protein_name": "Small ribosomal subunit protein uS4A", "gene_name": "RPS9A", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS4 RPS9A", "refseq_ac": "NP_015244", "gene_names_uniprotkb": "RPS9A; RPS13A; YS11A", "gene_names_refseq": "RPS9A", "protein_names_uniprotkb": "Small ribosomal subunit protein uS4A; 40S ribosomal protein S9-A; RP21; S13; YP28; YS11", "protein_names_refseq": "40S ribosomal protein uS4 RPS9A", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL081W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11701127;14562095;14562106;14976550;15590835;17287358;2041737;20702584;21109664;21126336;22096102;23749301;24374639;24524803;32597660;33491328;6814480;9169875;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS4 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3T6", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006412 translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O13516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13527-1", "uniprot_id": "YA11B_YEAST", "mass": 136732.0, "length": 1196, "protein_name": "Truncated transposon Ty1-A Gag-Pol polyprotein", "gene_name": "TY1B-A", "organism": "Yeast", "refseq_name": "truncated gag-pol fusion protein", "refseq_ac": "NP_009406", "gene_names_uniprotkb": "TY1B-A; YARCTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Truncated transposon Ty1-A Gag-Pol polyprotein; Pol-p63; Pol-p71; TY1B; Transposon Ty1 TYB polyprotein; p60; p84; p90", "protein_names_refseq": "truncated gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YAR009C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16093660;16093680;17330950;17563356;18407956;19684113;19779198;21177495;24374639;7731988;7941740;9582191", "class_list": "", "function": "Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPM1", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0032196 transposition;GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O13527-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13535-1", "uniprot_id": "YH11B_YEAST", "mass": 202817.0, "length": 1793, "protein_name": "Transposon Ty1-H Gag-Pol polyprotein", "gene_name": "TY1B-H", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_012086", "gene_names_uniprotkb": "TY1B-H; YHRCTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-H Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR214C-B)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;16093680;18407956;24374639;8091229;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DLG6", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O13535-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13547-1", "uniprot_id": "CCW14_YEAST", "mass": 23268.0, "length": 238, "protein_name": "Covalently-linked cell wall protein 14", "gene_name": "CCW14", "organism": "Yeast", "refseq_name": "Ccw14p", "refseq_ac": "NP_013495", "gene_names_uniprotkb": "CCW14; ICWP; SSR1; YLR391W-A", "gene_names_refseq": "CCW14; SSR1; YLR391W-A; YLR391W", "protein_names_uniprotkb": "Covalently-linked cell wall protein 14; Inner cell wall protein", "protein_names_refseq": "Ccw14p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR390W-A)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10322008;15781460;22106047;24374639;33491328;9079899;9169871", "class_list": "", "function": "Component of the inner layer of the cell wall., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ26", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0005739 mitochondrion;GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O13547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13563-1", "uniprot_id": "RPN13_YEAST", "mass": 17902.0, "length": 156, "protein_name": "26S proteasome regulatory subunit RPN13", "gene_name": "RPN13", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN13", "refseq_ac": "NP_013525", "gene_names_uniprotkb": "RPN13; DAQ1", "gene_names_refseq": "RPN13", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN13; Proteasome non-ATPase subunit 13", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN13", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR421C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11029046;14562095;14562106;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20486117;20702584;21126336;21177495;22218487;22814378;22927375;23749301;24374639;24909858;30181345;30516470;32597660;33481703;33491328;7957966;9169871", "class_list": "", "function": "Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ57", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005634 nucleus;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "O13563-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O14467-1", "uniprot_id": "MBF1_YEAST", "mass": 16404.0, "length": 151, "protein_name": "Multiprotein-bridging factor 1", "gene_name": "MBF1", "organism": "Yeast", "refseq_name": "multiprotein-bridging factor 1", "refseq_ac": "NP_014942", "gene_names_uniprotkb": "MBF1; SUF13", "gene_names_refseq": "MBF1; SUF13", "protein_names_uniprotkb": "Multiprotein-bridging factor 1; Suppressor of frameshift mutations protein 13", "protein_names_refseq": "multiprotein-bridging factor 1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR298C-A)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "12844361;14562095;14562106;15665377;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;24909858;30465652;32597660;33229814;33481703;33491328;36583309;9169874;9710580", "class_list": "", "function": "Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters (PubMed:9710580). Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation (PubMed:30465652, PubMed:36583309). Required to prevent stalled ribosomes from frameshifting (PubMed:30465652, PubMed:36583309)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Z8;Q7LGJ8;Q86ZS7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006351 DNA-templated transcription;GO:1990145 maintenance of translational fidelity;GO:0140469 GCN2-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "O14467-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O60200-1", "uniprot_id": "MDM35_YEAST", "mass": 9712.0, "length": 86, "protein_name": "Mitochondrial distribution and morphology protein 35", "gene_name": "MDM35", "organism": "Yeast", "refseq_name": "Mdm35p", "refseq_ac": "NP_012870", "gene_names_uniprotkb": "MDM35", "gene_names_refseq": "MDM35", "protein_names_uniprotkb": "Mitochondrial distribution and morphology protein 35", "protein_names_refseq": "Mdm35p", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YKL053C-A); (R-SCE-6803204)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11907266;14562095;14562106;17095012;17322287;20622808;20657548;22984289;24374639;26071601;26071602;26235513;8091862;8196765;9392081", "class_list": "", "function": "Involved in mitochondrial distribution and morphology. Mediates the import of UPS1, UPS2 and UPS3, 3 atypical mitochondrial intermembrane space (IMS) proteins lacking the two major IMS-targeting signals, into the intermembrane space. The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071601, PubMed:26071602, PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN4;Q6Q599", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0015914 phospholipid transport;GO:0007005 mitochondrion organization;GO:0097035 regulation of membrane lipid distribution;GO:0120010 intermembrane phospholipid transfer", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O60200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O74700-1", "uniprot_id": "TIM9_YEAST", "mass": 10202.0, "length": 87, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM9", "gene_name": "TIM9", "organism": "Yeast", "refseq_name": "protein transporter TIM9", "refseq_ac": "NP_010894", "gene_names_uniprotkb": "TIM9; YEL020BW", "gene_names_refseq": "TIM9", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM9", "protein_names_refseq": "protein transporter TIM9", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL020W-A); (R-SCE-1268020)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10369662;10995434;11483513;11509656;11867522;12138093;12391147;12656987;14973126;14978039;16039669;16823961;17322287;22814378;22984289;24374639;33481703;33491328;9169868;9822593;9889188", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM10, it may have a strong structural role., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLM8", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O74700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O94742-1", "uniprot_id": "SEM1_YEAST", "mass": 10386.0, "length": 89, "protein_name": "26S proteasome complex subunit SEM1", "gene_name": "SEM1", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit SEM1", "refseq_ac": "NP_010651", "gene_names_uniprotkb": "SEM1; DSH1", "gene_names_refseq": "DSS1; HOD1; SEM1", "protein_names_uniprotkb": "26S proteasome complex subunit SEM1", "protein_names_refseq": "proteasome regulatory particle lid subunit SEM1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR363W-A)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;15117943;15665377;17322287;19061648;19289793;19795423;19823750;20486117;24374639;24909858;33491328;9169867;9927667", "class_list": "", "function": "Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Also associates with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSZ2", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0070390 transcription export complex 2", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O94742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00044-1", "uniprot_id": "CYC1_YEAST", "mass": 12182.0, "length": 109, "protein_name": "Cytochrome c isoform 1", "gene_name": "CYC1", "organism": "Yeast", "refseq_name": "cytochrome c isoform 1", "refseq_ac": "NP_012582", "gene_names_uniprotkb": "CYC1; J1653", "gene_names_refseq": "CYC1", "protein_names_uniprotkb": "Cytochrome c isoform 1; Cytochrome c aerobic isoform; Iso-1-cytochrome c", "protein_names_refseq": "cytochrome c isoform 1", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858); thrombocytopenia (Disease Ontology:DOID:1588); pancreatic cancer (Disease Ontology:DOID:1793); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (sce:YJR048W); (R-SCE-111457); (R-SCE-3299685); (R-SCE-5620971); (R-SCE-611105)", "pathway_count": 5, "publication_count": 26, "publication_id_list": "10791961;10821864;11880631;14562106;18390544;2158927;2166169;222467;22814378;22984289;24374639;2822698;2832611;3009831;33491328;4348687;5771953;6273415;7814361;7851399;7975898;8641269;8901521;9169434;9220987;9866716", "class_list": "", "function": "Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of ubiquinol-cytochrome c oxidoreductase. Cytochrome c then transfers this electron to the dinuclear copper A center (CU(A)) of the COX2 subunit of cytochrome oxidase, the final protein carrier in the mitochondrial electron-transport chain. Isoform 1 (CYC1) is the predominant cytochrome c during aerobic/normoxic growth., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWL9", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P00044-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00045-1", "uniprot_id": "CYC7_YEAST", "mass": 12532.0, "length": 113, "protein_name": "Cytochrome c isoform 2", "gene_name": "CYC7", "organism": "Yeast", "refseq_name": "cytochrome c isoform 2", "refseq_ac": "NP_010875", "gene_names_uniprotkb": "CYC7; CYP3", "gene_names_refseq": "CYC7", "protein_names_uniprotkb": "Cytochrome c isoform 2; Cytochrome c hypoxic isoform; Iso-2-cytochrome c", "protein_names_refseq": "cytochrome c isoform 2", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858); thrombocytopenia (Disease Ontology:DOID:1588); pancreatic cancer (Disease Ontology:DOID:1793); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (sce:YEL039C); (R-SCE-111457); (R-SCE-3299685); (R-SCE-5620971); (R-SCE-611105)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "1326054;14562106;17322287;18390544;22984289;24374639;33481703;33491328;6244566;7814361;8411151;8636074;9169434;9169868", "class_list": "", "function": "Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of ubiquinol-cytochrome c oxidoreductase. Cytochrome c then transfers this electron to the dinuclear copper A center (CU(A)) of the COX2 subunit of cytochrome oxidase, the final protein carrier in the mitochondrial electron-transport chain. Isoform 2 (CYC7) is the predominant cytochrome c under anaerobic/hypoxic conditions., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLL0", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P00045-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00127-1", "uniprot_id": "QCR6_YEAST", "mass": 17257.0, "length": 147, "protein_name": "Cytochrome b-c1 complex subunit 6, mitochondrial", "gene_name": "QCR6", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase subunit 6", "refseq_ac": "NP_116691", "gene_names_uniprotkb": "QCR6; UCR6", "gene_names_refseq": "COR3; QCR6; UCR6", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 6, mitochondrial; Complex III subunit 6; Complex III subunit VI; Cytochrome c1 non-heme 17 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c oxidoreductase subunit 6; Ubiquinol-cytochrome c reductase 17 kDa protein", "protein_names_refseq": "ubiquinol--cytochrome-c reductase subunit 6", "tax_id": 559292, "disease": "mitochondrial complex III deficiency (Disease Ontology:DOID:0111139)", "pathway": " (sce:YFR033C); (R-SCE-611105); (R-SCE-9865878)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10764779;10775262;10873857;11726495;11880631;12782631;14562106;17337272;18390544;22984289;24374639;30598554;30598556;6329732;7670463;8686381", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTR6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0034399 nuclear periphery;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00128-1", "uniprot_id": "QCR7_YEAST", "mass": 14565.0, "length": 127, "protein_name": "Cytochrome b-c1 complex subunit 7, mitochondrial", "gene_name": "QCR7", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase subunit 7", "refseq_ac": "NP_010818", "gene_names_uniprotkb": "QCR7; CRO1; D9719.32; UCR7", "gene_names_refseq": "COR4; CRO1; QCR7; UCR7", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 7, mitochondrial; Complex III subunit 7; Complex III subunit VII; Ubiquinol-cytochrome c oxidoreductase subunit 7; Ubiquinol-cytochrome c reductase 14 kDa protein", "protein_names_refseq": "ubiquinol--cytochrome-c reductase subunit 7", "tax_id": 559292, "disease": "mitochondrial complex III deficiency nuclear type 3 (Disease Ontology:DOID:0080112); depressive disorder (Disease Ontology:DOID:1596); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (sce:YDR529C); (R-SCE-611105); (R-SCE-9865878)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10764779;10775262;10873857;11880631;12782631;14562106;18390544;22814378;24374639;30598554;30598556;6319130;9169867", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTF0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0099617 matrix side of mitochondrial inner membrane", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00128-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00163-1", "uniprot_id": "CYB_YEAST", "mass": 43656.0, "length": 385, "protein_name": "Cytochrome b", "gene_name": "COB", "organism": "Yeast", "refseq_name": "cytochrome b", "refseq_ac": "NP_009315", "gene_names_uniprotkb": "COB; CYTB", "gene_names_refseq": "COB1; COB; CYTB", "protein_names_uniprotkb": "Cytochrome b; 7.1.1.8; Complex III subunit 3; Complex III subunit CYTB; Complex III subunit III; Cytochrome b-c1 complex subunit 3; Cytochrome b-c1 complex subunit CYTB; Ubiquinol-cytochrome c oxidoreductase complex cytochrome b subunit", "protein_names_refseq": "cytochrome b", "tax_id": 559292, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); ovarian carcinoma (Disease Ontology:DOID:4001); thyrotoxicosis (Disease Ontology:DOID:7997); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:Q0105); (R-SCE-611105); (R-SCE-9865878)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10764779;10775262;10873857;11880631;18390544;24374639;2551731;30598554;30598556;6253454;6383504;7004642;7034963;7737175;8031140;9872396", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). Cytochrome b is a catalytic core subunit containing 2 b-type hemes BL and BH topographically segregated in the quinone reduction (Qi) and quinol oxidation (Q0) sites on opposite sides of the membrane (PubMed:18390544)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYK0;Q35802;Q35807;Q36301;Q9ZZW9", "ec_number_list": "7.1.1.8;3.4.24.64", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00175-1", "uniprot_id": "CYB2_YEAST", "mass": 65539.0, "length": 591, "protein_name": "L-lactate dehydrogenase (cytochrome)", "gene_name": "CYB2", "organism": "Yeast", "refseq_name": "L-lactate dehydrogenase (cytochrome)", "refseq_ac": "NP_013658", "gene_names_uniprotkb": "CYB2; YM9958.08C", "gene_names_refseq": "CYB2; FCB2", "protein_names_uniprotkb": "L-lactate dehydrogenase (cytochrome); 1.1.2.3; Cytochrome b2; FCB2; Flavocytochrome b2; L-LCR; L-lactate ferricytochrome c oxidoreductase", "protein_names_refseq": "L-lactate dehydrogenase (cytochrome)", "tax_id": 559292, "disease": "", "pathway": " (sce:YML054C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11502169;11914072;14562106;165435;17563122;22984289;2329585;24374639;3004948;3902473;4593578;6365548;776230;9169872", "class_list": "", "function": "Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate with subsequent transfer of electrons to cytochrome c (PubMed:11914072). Is involved in the utilization of (S)-lactate as a sole source of carbon for growth (PubMed:3004948). Can also use ferricyanide as an electron acceptor in vitro (PubMed:3004948, PubMed:4593578)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZC0", "ec_number_list": "1.1.2.3;7.1.2.2;2.3.3.1;7.1.1.8;3.4.24.64;4.2.1.3;1.1.1.41;2.5.1.39;3.6.1.-;1.1.2.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004460 L-lactate dehydrogenase (cytochrome) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0022904 respiratory electron transport chain;GO:0006089 lactate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P00175-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00330-1", "uniprot_id": "ADH1_YEAST", "mass": 36849.0, "length": 348, "protein_name": "Alcohol dehydrogenase 1", "gene_name": "ADH1", "organism": "Yeast", "refseq_name": "alcohol dehydrogenase ADH1", "refseq_ac": "NP_014555", "gene_names_uniprotkb": "ADH1; ADC1; O0947", "gene_names_refseq": "ADC1; ADH1", "protein_names_uniprotkb": "Alcohol dehydrogenase 1; 1.1.1.1; 1.1.1.54; 1.1.1.78; ADHI; Alcohol dehydrogenase I; NADH-dependent methylglyoxal reductase; YADH-1", "protein_names_refseq": "alcohol dehydrogenase ADH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL086C)", "pathway_count": 1, "publication_count": 38, "publication_id_list": "12702265;12722185;14690591;15665377;170911;17287358;17330950;17563356;18407956;19779198;19795423;19823750;2201405;22094012;22106047;22218487;23749301;241323;24374639;25157460;26743849;2937632;30516470;320000;32597660;33481703;33491328;33620215;3546317;4352908;6277922;6279086;6985717;7737086;7895733;8463307;8533473;9169874", "class_list": "", "function": "Preferentially fermentative isozyme that reduces acetaldehyde to ethanol during the fermentation of glucose. Major enzyme required for the conversion of acetaldehyde to ethanol (Probable) (PubMed:22094012). Plays a key role in the carbohydrate metabolism through the regeneration of NAD(+) from glycolytic NADH (Probable). In the reverse reaction, preferentially catalyzes the conversion of primary unbranched alcohols to their corresponding aldehydes. Also shows activity toward secondary alcohols (Probable). Most active with ethanol, and its activity decreases as the size of the alcohol is increased (PubMed:8463307)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Y3", "ec_number_list": "1.1.1.1;1.1.1.54;1.1.1.78;1.1.1.-;1.1.1.284", "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:1904408 melatonin binding;GO:0047655 allyl-alcohol dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway;GO:0019655 glycolytic fermentation to ethanol", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P00330-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00331-1", "uniprot_id": "ADH2_YEAST", "mass": 36732.0, "length": 348, "protein_name": "Alcohol dehydrogenase 2", "gene_name": "ADH2", "organism": "Yeast", "refseq_name": "alcohol dehydrogenase ADH2", "refseq_ac": "NP_014032", "gene_names_uniprotkb": "ADH2; ADR2; YM9952.05C", "gene_names_refseq": "ADH2; ADR2", "protein_names_uniprotkb": "Alcohol dehydrogenase 2; 1.1.1.1; ADHII; Alcohol dehydrogenase II; YADH-2", "protein_names_refseq": "alcohol dehydrogenase ADH2", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR303C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12702265;14562095;14562106;17287358;17330950;18407956;19779198;22094012;22218487;23749301;24374639;2937632;33491328;33502312;3546317;6279086;6337160;6985717;7895733;9032272;9169872;9298649", "class_list": "", "function": "Preferentially oxidative, glucose-repressed isozyme that catalyzes the conversion of ethanol to acetaldehyde. Main enzyme involved in ethanol consumption. Acts on a variety of primary unbranched aliphatic alcohols (Probable) (PubMed:3546317). Also produces ethanol from glucose, albeit less than ADH1 (PubMed:22094012)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D0", "ec_number_list": "1.1.1.1;1.1.1.54;1.1.1.78;1.1.1.-;1.1.1.284", "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:1990362 butanol dehydrogenase (NAD+) activity;GO:0120542 ethanol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006067 ethanol metabolic process;GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P00331-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00358-1", "uniprot_id": "G3P2_YEAST", "mass": 35847.0, "length": 332, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase 2", "gene_name": "TDH2", "organism": "Yeast", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2", "refseq_ac": "NP_012542", "gene_names_uniprotkb": "TDH2; GPD2; J1433", "gene_names_refseq": "GLD2; TDH2", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase 2; 1.2.1.12; GAPDH 2; Triose-phosphate dehydrogenase 1", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2", "tax_id": 559292, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YJR009C); (R-SCE-70171); (R-SCE-70263)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "11283598;13174589;14562106;15665377;17287358;1789010;20702584;22106047;24374639;27821475;2999100;33491328;3905788;4371815;6244283;7737086;7875559;8641269", "class_list": "", "function": "As a side activity, catalyzes the hydration of the nicotinamide ring of NADH or NADPH at the C6 position to give the corresponding hydrates, NADHX and NADPHX, which exist as R and S epimers, that cannot act as electron donors or acceptors and inhibit several dehydrogenases, making them toxic., [UniProtKB, PubMed, PubMed]; Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) involved in glycolysis and gluconeogenesis (PubMed:2999100). Catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate (PubMed:3905788). The contribution of the TDH1, TDH2, and TDH3 to the total glyceraldehyde-3-phosphate dehydrogenase activity is 10-15, 25-30, and 50-60%, respectively (PubMed:3905788)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWI4", "ec_number_list": "1.2.1.12", "go_molecular_function": "GO:0051287 NAD binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0050661 NADP binding;GO:1990841 promoter-specific chromatin binding;GO:1904408 melatonin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P00358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00359-1", "uniprot_id": "G3P3_YEAST", "mass": 35747.0, "length": 332, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase 3", "gene_name": "TDH3", "organism": "Yeast", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3", "refseq_ac": "NP_011708", "gene_names_uniprotkb": "TDH3; G7576; GPD3", "gene_names_refseq": "GLD1; HSP35; HSP36; SSS2; TDH3", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase 3; 1.2.1.12; GAPDH 3; Triose-phosphate dehydrogenase 1", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3", "tax_id": 559292, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YGR192C); (R-SCE-70171); (R-SCE-70263)", "pathway_count": 3, "publication_count": 38, "publication_id_list": "11283598;11502169;11946592;13174589;14562106;15665377;16823961;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22106047;22869137;23749301;24374639;24909858;27821475;2999100;30516470;32597660;33481703;33491328;36102610;385592;3905788;4371815;7645350;7737086;7875559;7895733;9169869", "class_list": "", "function": "As a side activity, catalyzes the hydration of the nicotinamide ring of NADH or NADPH at the C6 position to give the corresponding hydrates, NADHX and NADPHX, which exist as R and S epimers, that cannot act as electron donors or acceptors and inhibit several dehydrogenases, making them toxic., [UniProtKB, PubMed, PubMed]; Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) involved in glycolysis and gluconeogenesis (PubMed:2999100). Catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate (PubMed:3905788). The contribution of the TDH1, TDH2, and TDH3 to the total glyceraldehyde-3-phosphate dehydrogenase activity is 10-15, 25-30, and 50-60%, respectively (PubMed:3905788)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUX4;Q6Q5P9", "ec_number_list": "1.2.1.12", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0051287 NAD binding;GO:0020037 heme binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0006094 gluconeogenesis;GO:0015886 heme transport;GO:0006096 glycolytic process;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P00359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00360-1", "uniprot_id": "G3P1_YEAST", "mass": 35750.0, "length": 332, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase 1", "gene_name": "TDH1", "organism": "Yeast", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1", "refseq_ac": "NP_012483", "gene_names_uniprotkb": "TDH1; GPD1; J1154; SSS2", "gene_names_refseq": "GLD3; TDH1", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase 1; 1.2.1.12; GAPDH 1; Triose-phosphate dehydrogenase 1", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1", "tax_id": 559292, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YJL052W); (R-SCE-70171); (R-SCE-70263)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10930071;11283598;11502169;13174589;14562106;15665377;17287358;17322287;18407956;19779198;20702584;24374639;27821475;2999100;33491328;3905788;4371815;6833300;7875559;8641269;9509572", "class_list": "", "function": "As a side activity, catalyzes the hydration of the nicotinamide ring of NADH or NADPH at the C6 position to give the corresponding hydrates, NADHX and NADPHX, which exist as R and S epimers, that cannot act as electron donors or acceptors and inhibit several dehydrogenases, making them toxic., [UniProtKB, PubMed, PubMed]; Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) involved in glycolysis and gluconeogenesis (PubMed:2999100). Catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate (PubMed:3905788). The contribution of the TDH1, TDH2, and TDH3 to the total glyceraldehyde-3-phosphate dehydrogenase activity is 10-15, 25-30, and 50-60%, respectively (PubMed:3905788). May be involved in a process other than glycolysis because it is synthesized by cells in stationary phase (PubMed:7875559)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWD1", "ec_number_list": "1.2.1.12", "go_molecular_function": "GO:0051287 NAD binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0050661 NADP binding;GO:1904408 melatonin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P00360-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00401-1", "uniprot_id": "COX1_YEAST", "mass": 58798.0, "length": 534, "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "COX1", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit 1", "refseq_ac": "NP_009305", "gene_names_uniprotkb": "COX1; OXI3", "gene_names_refseq": "COX1; OXI3", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 1; 7.1.1.9; Cytochrome c oxidase polypeptide I", "protein_names_refseq": "cytochrome c oxidase subunit 1", "tax_id": 559292, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:Q0045); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10764779;10775262;1331058;24374639;2664712;30598554;30598556;32291341;33016568;37188665;39300056;6254986;7851399;9872396", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX1 is a catalytic core subunit containing heme A and the active site BNC with heme A3 and the copper atom CU(B) (PubMed:30598554)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYF6;Q9ZZX6", "ec_number_list": "7.1.1.9;3.4.24.-;3.6.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P00401-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00410-1", "uniprot_id": "COX2_YEAST", "mass": 28567.0, "length": 251, "protein_name": "Cytochrome c oxidase subunit 2", "gene_name": "COX2", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit 2", "refseq_ac": "NP_009326", "gene_names_uniprotkb": "COX2; OXI1", "gene_names_refseq": "COX2; OXI1; OXII", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 2; 7.1.1.9; Cytochrome c oxidase polypeptide II", "protein_names_refseq": "cytochrome c oxidase subunit 2", "tax_id": 559292, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); Huntington's disease (Disease Ontology:DOID:12858); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (sce:Q0250)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10764779;10775262;1331058;225327;226981;230513;24374639;2547760;30598554;30598556;6313350;7851399;8879245;9872396", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX2 is a catalytic core subunit which transfers the electrons from cytochrome c via its dinuclear copper A center (CU(A)) to the BNC of the COX1 (PubMed:30598554)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYF9", "ec_number_list": "7.1.1.9;3.4.24.-", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P00410-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00420-1", "uniprot_id": "COX3_YEAST", "mass": 30360.0, "length": 269, "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "COX3", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit 3", "refseq_ac": "NP_009328", "gene_names_uniprotkb": "COX3; OXI2", "gene_names_refseq": "COX3; OXI2", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 3; 7.1.1.9; Cytochrome c oxidase polypeptide III", "protein_names_refseq": "cytochrome c oxidase subunit 3", "tax_id": 559292, "disease": "MELAS syndrome (Disease Ontology:DOID:3687)", "pathway": " (sce:Q0275)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10764779;10775262;1331058;24374639;30598554;30598556;3549452;6248512;7851399;9872396", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX3 is a catalytic core subunit (PubMed:30598554)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7P087;Q9ZZV9", "ec_number_list": "7.1.1.9", "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0009060 aerobic respiration;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00420-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00424-1", "uniprot_id": "COX5A_YEAST", "mass": 17140.0, "length": 153, "protein_name": "Cytochrome c oxidase subunit 5A, mitochondrial", "gene_name": "COX5A", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit Va", "refseq_ac": "NP_014346", "gene_names_uniprotkb": "COX5A; N2474; YNL2474W", "gene_names_refseq": "COX5A", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase polypeptide Va", "protein_names_refseq": "cytochrome c oxidase subunit Va", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 16 (Disease Ontology:DOID:0070501); protein-energy malnutrition (Disease Ontology:DOID:11801); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (sce:YNL052W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10764779;10775262;1331058;14562106;17322287;24374639;2546055;2824989;2836092;2986105;2991248;30598554;30598556;6300105;6327686;7851399;8533472;9169434;9169873", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1C7", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P00424-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00431-1", "uniprot_id": "CCPR_YEAST", "mass": 40353.0, "length": 361, "protein_name": "Cytochrome c peroxidase, mitochondrial", "gene_name": "CCP1", "organism": "Yeast", "refseq_name": "cytochrome-c peroxidase", "refseq_ac": "NP_012992", "gene_names_uniprotkb": "CCP1; CCP; CPO", "gene_names_refseq": "CCP1", "protein_names_uniprotkb": "Cytochrome c peroxidase, mitochondrial; 1.11.1.5; CCP", "protein_names_refseq": "cytochrome-c peroxidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR066C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10722697;11170452;12774122;14562106;17245427;17322287;18407956;2169873;22984289;24374639;2851317;33491328;6092361;6257176;6286684;6294090;8196765;8384877;8673607", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC7;Q6Q5M9", "ec_number_list": "1.11.1.5", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0004130 cytochrome-c peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0000302 response to reactive oxygen species;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P00431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00445-1", "uniprot_id": "SODC_YEAST", "mass": 15855.0, "length": 154, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "SOD1", "organism": "Yeast", "refseq_name": "superoxide dismutase SOD1", "refseq_ac": "NP_012638", "gene_names_uniprotkb": "SOD1; J1968", "gene_names_refseq": "CRS4; SOD1", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; 1.8.-.-; Hydrogen sulfide oxidase", "protein_names_refseq": "superoxide dismutase SOD1", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dry eye syndrome (Disease Ontology:DOID:10140); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); renal artery obstruction (Disease Ontology:DOID:2972); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); nutritional deficiency disease (Disease Ontology:DOID:5113); myocardial infarction (Disease Ontology:DOID:5844); prion disease (Disease Ontology:DOID:649); progressive supranuclear palsy (Disease Ontology:DOID:678); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (sce:YJR104C); (R-SCE-114608); (R-SCE-3299685)", "pathway_count": 3, "publication_count": 38, "publication_id_list": "10026301;11500508;11524675;14562106;15069187;15166219;15665377;1602482;16234242;17287358;17322287;17563356;1772629;18407956;18948262;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22984289;23749301;24374639;24647101;24909858;27821475;29727620;32597660;3290902;33481703;33491328;36630448;6993479;8641269;8652572", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems (PubMed:18948262). Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides (PubMed:36630448)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWS3;Q68HB2", "ec_number_list": "1.8.-.-;1.15.1.1;3.6.4.-", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity;GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0034599 cellular response to oxidative stress;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P00445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00546-1", "uniprot_id": "CDK1_YEAST", "mass": 34061.0, "length": 298, "protein_name": "Cyclin-dependent kinase 1", "gene_name": "CDC28", "organism": "Yeast", "refseq_name": "cyclin-dependent serine/threonine-protein kinase CDC28", "refseq_ac": "NP_009718", "gene_names_uniprotkb": "CDC28; CDK1; HSL5; SRM5; YBR1211", "gene_names_refseq": "CDC28; CDK1; HSL5; SRM5", "protein_names_uniprotkb": "Cyclin-dependent kinase 1; 2.7.11.22; CDK1; Cell division control protein 28; Cell division protein kinase 1", "protein_names_refseq": "cyclin-dependent serine/threonine-protein kinase CDC28", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YBR160W); (R-SCE-176187); (R-SCE-68962)", "pathway_count": 3, "publication_count": 69, "publication_id_list": "10454545;10490648;10512868;10793138;10871278;10998356;11027284;11160822;11470822;11739722;11827161;12840070;14562106;14574415;15665377;1731250;17330950;18231587;18316413;18407956;19158081;19211841;19566963;19684113;19779198;19795423;19823750;19958388;20489023;20702584;21126336;21151918;21177495;21658602;22156209;22561345;22814378;23749301;23751495;23861665;24374639;24842996;25340401;26040289;2664468;26715668;27558135;27821475;29561844;30516470;30927017;32401321;32597660;33033113;33481703;33491328;33585466;6361575;7597849;7730408;7813418;8253069;8647431;8752211;8754858;8930890;9566911;9819350;9891070", "class_list": "", "function": "Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles (By similarity). Required to drive the G1-S transition (PubMed:2664468). More than 200 substrates have been identified (PubMed:14574415). Substrate specificity is in part regulated by the bound cyclin protein (By similarity). Phosphorylates YTA7 during S-phase to promote transcription of histones (PubMed:22156209). May phosphorylate CNN1, to contribute to the enrichment of CNN1 on anaphase kinetochores (PubMed:22561345)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQF5", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.7.-;2.7.7.7;2.7.12.1;2.7.11.24;3.1.11.-;2.7.11.17;2.7.11.23;2.7.11.25;3.6.4.12;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042393 histone binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0010494 cytoplasmic stress granule;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0045875 negative regulation of sister chromatid cohesion;GO:0051446 positive regulation of meiotic cell cycle;GO:1905634 regulation of protein localization to chromatin;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 7.0, "record_id": "P00546-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00549-1", "uniprot_id": "KPYK1_YEAST", "mass": 54545.0, "length": 500, "protein_name": "Pyruvate kinase 1", "gene_name": "CDC19", "organism": "Yeast", "refseq_name": "pyruvate kinase CDC19", "refseq_ac": "NP_009362", "gene_names_uniprotkb": "CDC19; PYK1", "gene_names_refseq": "CDC19; PYK1", "protein_names_uniprotkb": "Pyruvate kinase 1; 2.7.1.40; PK 1; cell division cycle protein 19", "protein_names_refseq": "pyruvate kinase CDC19", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (sce:YAL038W); (R-SCE-6798695); (R-SCE-70171); (R-SCE-70268)", "pathway_count": 4, "publication_count": 31, "publication_id_list": "10413488;11283598;14562106;15665377;16426231;16879422;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20639203;20702584;21126336;22106047;22218487;23749301;24374639;24909858;2653861;32597660;33481703;33491328;34965436;36102610;6185493;7731988;9519410", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 52, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH8;Q2VQG5", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030955 potassium ion binding;GO:0004743 pyruvate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006096 glycolytic process;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P00549-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00560-1", "uniprot_id": "PGK_YEAST", "mass": 44738.0, "length": 416, "protein_name": "Phosphoglycerate kinase", "gene_name": "PGK1", "organism": "Yeast", "refseq_name": "phosphoglycerate kinase", "refseq_ac": "NP_009938", "gene_names_uniprotkb": "PGK1; YCR12W", "gene_names_refseq": "PGK1", "protein_names_uniprotkb": "Phosphoglycerate kinase; 2.7.2.3", "protein_names_refseq": "phosphoglycerate kinase", "tax_id": 559292, "disease": "phosphoglycerate kinase 1 deficiency (Disease Ontology:DOID:0111933); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); hemolytic anemia (Disease Ontology:DOID:583)", "pathway": " (sce:YCR012W); (R-SCE-70171); (R-SCE-70263)", "pathway_count": 3, "publication_count": 33, "publication_id_list": "11283598;11502169;14562106;15665377;1574125;1626432;1628654;16823961;17287358;17330950;17563356;18407956;19779198;19795423;19823750;21126336;22106047;22218487;22814378;23749301;24374639;30516470;32597660;33481703;33491328;6254992;6281737;6296791;6347186;6765200;7287307;8672447;9509572", "class_list": "", "function": "Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:6254992). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (By similarity). Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR21", "ec_number_list": "2.7.2.3", "go_molecular_function": "GO:0004618 phosphoglycerate kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P00560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00572-1", "uniprot_id": "KTHY_YEAST", "mass": 24687.0, "length": 216, "protein_name": "Thymidylate kinase", "gene_name": "CDC8", "organism": "Yeast", "refseq_name": "bifunctional thymidylate/uridylate kinase", "refseq_ac": "NP_012591", "gene_names_uniprotkb": "CDC8; J1715", "gene_names_refseq": "CDC8", "protein_names_uniprotkb": "Thymidylate kinase; 2.7.4.9; dTMP kinase", "protein_names_refseq": "bifunctional thymidylate/uridylate kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR057W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;24374639;33491328;3550432;6088527;6371491;8641269;8840504;9253404;9521686", "class_list": "", "function": "Catalyzes the conversion of dTMP to dTDP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWM8", "ec_number_list": "2.7.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0004798 dTMP kinase activity;GO:0004550 nucleoside diphosphate kinase activity;GO:0120136 dUMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006233 dTDP biosynthetic process;GO:0006227 dUDP biosynthetic process;GO:0006235 dTTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00635-1", "uniprot_id": "PPA5_YEAST", "mass": 52859.0, "length": 467, "protein_name": "Repressible acid phosphatase", "gene_name": "PHO5", "organism": "Yeast", "refseq_name": "acid phosphatase PHO5", "refseq_ac": "NP_009651", "gene_names_uniprotkb": "PHO5; YBR0814", "gene_names_refseq": "PHO5", "protein_names_uniprotkb": "Repressible acid phosphatase; 3.1.3.2; P60", "protein_names_refseq": "acid phosphatase PHO5", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 16 (Disease Ontology:DOID:0112333); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (sce:YBR093C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;16278456;24374639;33481703;3537710;6093051;6300772;7813418;7900426", "class_list": "", "function": "Partially mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and NPP2., [UniProtKB, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ94", "ec_number_list": "3.1.3.2;3.1.3.1;3.1.3.54;3.1.7.6;3.1.3.48", "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0071944 cell periphery;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process;GO:0008361 regulation of cell size;GO:0016036 cellular response to phosphate starvation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P00635-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00724-1", "uniprot_id": "INV2_YEAST", "mass": 60639.0, "length": 532, "protein_name": "Invertase 2", "gene_name": "SUC2", "organism": "Yeast", "refseq_name": "beta-fructofuranosidase SUC2", "refseq_ac": "NP_012104", "gene_names_uniprotkb": "SUC2", "gene_names_refseq": "SUC2", "protein_names_uniprotkb": "Invertase 2; 3.2.1.26; Beta-fructofuranosidase 2; Saccharase", "protein_names_refseq": "beta-fructofuranosidase SUC2", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL162W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;1744075;1888528;2113524;24374639;3284881;3537718;6300785;6341817;6396505;7039847;9169870", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 14, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 14, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 9, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6VVC4;Q12671", "ec_number_list": "", "go_molecular_function": "GO:0004575 sucrose alpha-glucosidase activity;GO:0004564 beta-fructofuranosidase activity;GO:0051670 inulinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0005987 sucrose catabolic process;GO:0010147 fructan catabolic process;GO:0034484 raffinose catabolic process;GO:1902927 inulin catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P00724-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00729-1", "uniprot_id": "CBPY_YEAST", "mass": 59802.0, "length": 532, "protein_name": "Carboxypeptidase Y", "gene_name": "PRC1", "organism": "Yeast", "refseq_name": "carboxypeptidase C PRC1", "refseq_ac": "NP_014026", "gene_names_uniprotkb": "PRC1", "gene_names_refseq": "CPY1; LBC1; PRC1", "protein_names_uniprotkb": "Carboxypeptidase Y; 3.4.16.5; CPD-Y; Carboxypeptidase YSCY; cpY", "protein_names_refseq": "carboxypeptidase C PRC1", "tax_id": 559292, "disease": "brain small vessel disease 6 with leukoencephalopathy (Disease Ontology:DOID:0061236); galactosialidosis (Disease Ontology:DOID:0080540); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (sce:YMR297W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;15713484;17408619;19897216;23708375;24374639;25214228;2639680;28189789;29514932;3028649;348476;7727362;7904479;8679540;9169872", "class_list": "", "function": "Vacuolar serine-type carboxypeptidase involved in degradation of small peptides (PubMed:8679540). Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (PubMed:8679540). Also plays a role in breakdown of the autophagic body and the autophagosome-dependent protein synthesis (PubMed:29514932). Plays a key role in phytochelatin (PC) synthesis from glutathione (GSH) by cleaving the Gly from GSH and form the PC-peptides of the structure (gamma-Glu-Cys)2-Gly (PubMed:17408619). Also involved in resistance to xenobiotics via the degradation of glutathione-S-conjugates (PubMed:19897216)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W0C4", "ec_number_list": "", "go_molecular_function": "GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005775 vacuolar lumen;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0016236 macroautophagy;GO:0006995 cellular response to nitrogen starvation;GO:0031638 zymogen activation;GO:0046938 phytochelatin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P00729-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00812-1", "uniprot_id": "ARGI_YEAST", "mass": 35662.0, "length": 333, "protein_name": "Arginase", "gene_name": "CAR1", "organism": "Yeast", "refseq_name": "arginase", "refseq_ac": "NP_015214", "gene_names_uniprotkb": "CAR1; LPH15W", "gene_names_refseq": "CAR1; LPH15", "protein_names_uniprotkb": "Arginase; 3.5.3.1", "protein_names_refseq": "arginase", "tax_id": 559292, "disease": "colitis (Disease Ontology:DOID:0060180); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); silicosis (Disease Ontology:DOID:10325); hypertension (Disease Ontology:DOID:10763); uveitis (Disease Ontology:DOID:13141); cholestasis (Disease Ontology:DOID:13580); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); liver disease (Disease Ontology:DOID:409); ureteral obstruction (Disease Ontology:DOID:5199); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); hyperargininemia (Disease Ontology:DOID:9278)", "pathway": " (sce:YPL111W); (R-SCE-6798695); (R-SCE-70635); (R-SCE-9837999)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "14562106;18407956;1939179;19779198;19795423;19823750;21126336;22814378;23749301;24374639;24909858;2983306;32597660;33481703;33491328;6094498;9169875", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Q6", "ec_number_list": "3.5.3.1;7.1.2.2;2.3.3.1;2.4.1.1;3.4.23.25;4.2.1.2;3.6.4.10;4.98.1.1;4.2.1.3;1.2.4.2;1.1.1.37;2.7.11.13;3.6.4.6;2.3.1.16;1.2.4.1;1.11.1.27;1.11.1.25;3.4.21.53;1.1.1.205;2.3.1.41;2.7.1.35;1.2.1.4;1.2.1.5;6.1.1.5;3.5.1.3;2.3.3.10;4.6.1.19;3.-.-.-;3.2.1.14;5.3.4.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030145 manganese ion binding;GO:0004053 arginase activity;GO:0090369 ornithine carbamoyltransferase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043332 mating projection tip", "go_biological_process": "GO:0000050 urea cycle;GO:0006525 arginine metabolic process;GO:0090368 regulation of ornithine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P00812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00815-1", "uniprot_id": "HIS2_YEAST", "mass": 87721.0, "length": 799, "protein_name": "Histidine biosynthesis trifunctional protein", "gene_name": "HIS4", "organism": "Yeast", "refseq_name": "trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase", "refseq_ac": "NP_009900", "gene_names_uniprotkb": "HIS4; YCL183; YCL30C", "gene_names_refseq": "HIS4", "protein_names_uniprotkb": "Histidine biosynthesis trifunctional protein", "protein_names_refseq": "trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL030C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;1574125;18407956;1897318;20489023;24374639;2991923;33229814;33481703;33491328;6250062;7049842;8336737", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQY5", "ec_number_list": "1.1.1.23;3.5.4.19;3.6.1.31", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051287 NAD binding;GO:0004399 histidinol dehydrogenase activity;GO:0004635 phosphoribosyl-AMP cyclohydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000105 L-histidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00815-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00817-1", "uniprot_id": "IPYR_YEAST", "mass": 32300.0, "length": 287, "protein_name": "Inorganic pyrophosphatase", "gene_name": "IPP1", "organism": "Yeast", "refseq_name": "inorganic diphosphatase IPP1", "refseq_ac": "NP_009565", "gene_names_uniprotkb": "IPP1; PPA1; PPA; YBR0202", "gene_names_refseq": "IPP1; PPA1", "protein_names_uniprotkb": "Inorganic pyrophosphatase; 3.6.1.1; PPase; Pyrophosphate phospho-hydrolase", "protein_names_refseq": "inorganic diphosphatase IPP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR011C); (R-SCE-379716); (R-SCE-379726); (R-SCE-71737)", "pathway_count": 4, "publication_count": 30, "publication_id_list": "1322842;14562106;15665377;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;2160278;22106047;22218487;23749301;24374639;2849749;30516470;32597660;33481703;33491328;340461;6101539;7813418;7895733;8935650;8994974;9878371", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ12", "ec_number_list": "3.6.1.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004427 inorganic diphosphate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P00817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00830-1", "uniprot_id": "ATPB_YEAST", "mass": 54794.0, "length": 511, "protein_name": "ATP synthase subunit beta, mitochondrial", "gene_name": "ATP2", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit beta", "refseq_ac": "NP_012655", "gene_names_uniprotkb": "ATP2; 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F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7P052;Q95A27", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00854-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00890-1", "uniprot_id": "CISY1_YEAST", "mass": 53360.0, "length": 479, "protein_name": "Citrate synthase, mitochondrial", "gene_name": "CIT1", "organism": "Yeast", "refseq_name": "citrate (Si)-synthase CIT1", "refseq_ac": "NP_014398", "gene_names_uniprotkb": "CIT1; 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GPM; YKL607", "gene_names_refseq": "GPM1", "protein_names_uniprotkb": "Phosphoglycerate mutase 1; 5.4.2.11; BPG-dependent PGAM 1; MPGM 1; PGAM 1; Phosphoglyceromutase 1", "protein_names_refseq": "phosphoglycerate mutase GPM1", "tax_id": 559292, "disease": "myoglobinuria (Disease Ontology:DOID:0080108); familial erythrocytosis 8 (Disease Ontology:DOID:0111630)", "pathway": " (sce:YKL152C); (R-SCE-6798695); (R-SCE-70171); (R-SCE-70263)", "pathway_count": 4, "publication_count": 40, "publication_id_list": "10064712;10369755;10531478;11283598;1386023;14562095;14562106;15665377;16823961;16962558;17287358;17330950;17563356;1834353;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;22814378;22984289;23749301;24374639;2831102;30516470;32597660;33481703;33491328;6115412;6127696;8091859;8196765;8240286;8462867;9509572;9512715", "class_list": "", "function": "Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX45;Q02117", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0004619 phosphoglycerate mutase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P00950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00958-1", "uniprot_id": "SYMC_YEAST", "mass": 85678.0, "length": 751, "protein_name": "Methionine--tRNA ligase, cytoplasmic", "gene_name": "MES1", "organism": "Yeast", "refseq_name": "methionine--tRNA ligase MES1", "refseq_ac": "NP_011780", "gene_names_uniprotkb": "MES1", "gene_names_refseq": "MES1", "protein_names_uniprotkb": "Methionine--tRNA ligase, cytoplasmic; 6.1.1.10; MetRS; Methionyl-tRNA synthetase", "protein_names_refseq": "methionine--tRNA ligase MES1", "tax_id": 559292, "disease": "nonphotosensitive trichothiodystrophy 9 (Disease Ontology:DOID:0061024); hereditary spastic paraplegia 70 (Disease Ontology:DOID:0070454); Charcot-Marie-Tooth disease axonal type 2U (Disease Ontology:DOID:0110173); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120)", "pathway": " (sce:YGR264C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11069915;11726524;14562106;16914447;18407956;1915850;19795423;19823750;23749301;24374639;32597660;3312199;33481703;33491328;3905796;6341994;6371805;8895587;9090059;9169869;9659920", "class_list": "", "function": "Catalyzes the attachment of methionine to tRNA(Met) in a two-step reaction: methionine is first activated by ATP to form Met-AMP and then transferred to the acceptor end of tRNA(Met)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV43", "ec_number_list": "6.1.1.10", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0005524 ATP binding;GO:0004825 methionine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0017102 methionyl glutamyl tRNA synthetase complex;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006424 glutamyl-tRNA aminoacylation;GO:0006431 methionyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P00958-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01094-1", "uniprot_id": "IPA3_YEAST", "mass": 7707.0, "length": 68, "protein_name": "Protease A inhibitor 3", "gene_name": "PAI3", "organism": "Yeast", "refseq_name": "Pai3p", "refseq_ac": "NP_013899", "gene_names_uniprotkb": "PAI3; YM8010.04C", "gene_names_refseq": "PAI3", "protein_names_uniprotkb": "Protease A inhibitor 3; Proteinase inhibitor I(A)3; Proteinase yscA-inhibitor; Saccharopepsin inhibitor", "protein_names_refseq": "Pai3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR174C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10655612;17322287;18407956;2037077;24374639;33491328;9169872", "class_list": "", "function": "Specific and potent inhibitor for yeast aspartic protease A (yscA). The proteinase acts as a folding template stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZZ6", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004866 endopeptidase inhibitor activity;GO:0019828 aspartic-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005773 vacuole;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007039 protein catabolic process in the vacuole", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01094-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01119-1", "uniprot_id": "RAS1_YEAST", "mass": 34347.0, "length": 309, "protein_name": "Ras-like protein 1", "gene_name": "RAS1", "organism": "Yeast", "refseq_name": "Ras family GTPase RAS1", "refseq_ac": "NP_014744", "gene_names_uniprotkb": "RAS1; YOR3205W", "gene_names_refseq": "RAS1", "protein_names_uniprotkb": "Ras-like protein 1; 3.6.5.2", "protein_names_refseq": "Ras family GTPase RAS1", "tax_id": 559292, "disease": "Costello syndrome (Disease Ontology:DOID:0050469); cardiomyopathy (Disease Ontology:DOID:0050700); Noonan syndrome 3 (Disease Ontology:DOID:0060581); RASopathy (Disease Ontology:DOID:0080690); Noonan syndrome 12 (Disease Ontology:DOID:0112170); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); cervical cancer (Disease Ontology:DOID:4362); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YOR101W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;1763050;18407956;19684113;19779198;19795423;19823750;2050108;22814378;23749301;24374639;27261458;30516470;32597660;33481703;33491328;3513173;6328429;6365329;7593165;9065405;9169874;9200815", "class_list": "", "function": "The S.cerevisiae Ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-AMP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2G2", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007265 Ras protein signal transduction;GO:0007163 establishment or maintenance of cell polarity;GO:0045762 positive regulation of adenylate cyclase activity;GO:0097271 protein localization to bud neck", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P01119-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01120-1", "uniprot_id": "RAS2_YEAST", "mass": 34705.0, "length": 322, "protein_name": "Ras-like protein 2", "gene_name": "RAS2", "organism": "Yeast", "refseq_name": "Ras family GTPase RAS2", "refseq_ac": "NP_014301", "gene_names_uniprotkb": "RAS2; ASC1; CTN5; GLC5; N2198", "gene_names_refseq": "CTN5; CYR3; GLC5; RAS2; TSL7", "protein_names_uniprotkb": "Ras-like protein 2; 3.6.5.2", "protein_names_refseq": "Ras family GTPase RAS2", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); Noonan syndrome 3 (Disease Ontology:DOID:0060581); RASopathy (Disease Ontology:DOID:0080690); Noonan syndrome 12 (Disease Ontology:DOID:0112170); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); cervical cancer (Disease Ontology:DOID:4362); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YNL098C); (R-SCE-9696273)", "pathway_count": 2, "publication_count": 38, "publication_id_list": "10744740;11875433;14562106;15665377;17287358;17330950;17563356;1763050;18407956;1917931;19684113;19779198;19795423;19823750;20388513;2050108;20702584;21126336;21177495;22106047;22218487;22814378;23749301;2406252;24374639;2663844;30516470;32597660;33481703;33491328;6327067;6328429;6365329;8150278;8701612;9065405;9169873;9228053", "class_list": "", "function": "The S.cerevisiae Ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-AMP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W181;Q45U01", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5;3.4.-.-;1.2.1.3;1.2.1.64", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0016236 macroautophagy;GO:0007265 Ras protein signal transduction;GO:0032880 regulation of protein localization;GO:0042149 cellular response to glucose starvation;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P01120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01123-1", "uniprot_id": "YPT1_YEAST", "mass": 23214.0, "length": 206, "protein_name": "GTP-binding protein YPT1", "gene_name": "YPT1", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT1", "refseq_ac": "NP_116615", "gene_names_uniprotkb": "YPT1; YP2", "gene_names_refseq": "YPT1", "protein_names_uniprotkb": "GTP-binding protein YPT1; Protein YP2; Rab GTPase YPT1; Transport GTPase YPT1", "protein_names_refseq": "Rab family GTPase YPT1", "tax_id": 559292, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YFL038C); (R-SCE-162658); (R-SCE-204005); (R-SCE-6807878); (R-SCE-6811434); (R-SCE-6811440); (R-SCE-8873719); (R-SCE-8876198)", "pathway_count": 8, "publication_count": 39, "publication_id_list": "10071213;11102533;11359917;11785952;11879636;11943201;12189143;12802060;14576435;15082776;16034420;16395334;17322287;17563356;18407956;18585354;19779198;19795423;19823750;2009858;20375281;20702584;21126336;22106047;23749301;24374639;24909858;3042385;32597660;3286011;3311726;33481703;33491328;6318115;7593181;7670463;8898359;9447979;9819430", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. YPT1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Vesicular transport depends on shuttling of YPT1 between membrane and cytosol by GDI1, probably by recycling it to its membrane of origin after a vesicle fusion event. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTJ2", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P01123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02293-1", "uniprot_id": "H2B1_YEAST", "mass": 14252.0, "length": 131, "protein_name": "Histone H2B.1", "gene_name": "HTB1", "organism": "Yeast", "refseq_name": "histone H2B", "refseq_ac": "NP_010510", "gene_names_uniprotkb": "HTB1; H2B1; SPT12; YD9934.09C", "gene_names_refseq": "HTB1; SPT12", "protein_names_uniprotkb": "Histone H2B.1; Suppressor of Ty protein 12", "protein_names_refseq": "histone H2B", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR224C)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10642555;10777603;11545749;11973294;12152067;12535538;12535539;14563679;14660635;14752010;15166219;15186774;15280549;15632065;15632126;15652479;15657441;15657442;15970663;16432255;16598039;17322287;18641662;19113941;2188095;22389435;22814378;24374639;32933557;33502312;7002547;7006833;7885847;9169867", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSK6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0006301 DNA damage tolerance", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P02293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02294-1", "uniprot_id": "H2B2_YEAST", "mass": 14237.0, "length": 131, "protein_name": "Histone H2B.2", "gene_name": "HTB2", "organism": "Yeast", "refseq_name": "histone H2B", "refseq_ac": "NP_009553", "gene_names_uniprotkb": "HTB2; H2B2; YBL0104", "gene_names_refseq": "HTB2", "protein_names_uniprotkb": "Histone H2B.2", "protein_names_refseq": "histone H2B", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL002W)", "pathway_count": 1, "publication_count": 41, "publication_id_list": "10777603;11545749;11566884;12152067;12535538;12535539;14562106;14563679;14660635;14752010;15166219;15186774;15280549;15632065;15652479;15657441;15657442;15970663;16598039;16631569;17287358;17322287;18086883;18407956;19113941;19779198;20190278;21177495;22389435;22814378;23749301;24374639;32597660;32933557;33491328;33502312;39601790;7002547;7006833;7813418;8091860", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ00", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P02294-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02309-1", "uniprot_id": "H4_YEAST", "mass": 11368.0, "length": 103, "protein_name": "Histone H4", "gene_name": "HHF1; HHF2", "organism": "Yeast", "refseq_name": "histone H4", "refseq_ac": "NP_009563", "gene_names_uniprotkb": "HHF1; HHF2; N2752; YBR0122", "gene_names_refseq": "HHF1", "protein_names_uniprotkb": "Histone H4", "protein_names_refseq": "histone H4", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR009C); (sce:YNL030W); (R-SCE-2299718); (R-SCE-3214842); (R-SCE-3214847); (R-SCE-3214858); (R-SCE-4551638)", "pathway_count": 7, "publication_count": 35, "publication_id_list": "11080160;11566884;14562106;15150415;15823538;16135807;16631569;16768447;16980586;17287358;17289592;17322287;18407956;19113941;19779198;20190278;21412236;22020126;22343720;22389435;24374639;27105113;30454561;31542297;32064518;32597660;32933557;33481703;33491328;6310494;6355483;7002547;7813418;9169873;9391047", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ10", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P02309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02400-1", "uniprot_id": "RLA4_YEAST", "mass": 11050.0, "length": 110, "protein_name": "Large ribosomal subunit protein P2B", "gene_name": "RPP2B", "organism": "Yeast", "refseq_name": "ribosomal protein P2 RPP2B", "refseq_ac": "NP_010670", "gene_names_uniprotkb": "RPP2B; L12EIA; RPL45; RPLA4", "gene_names_refseq": "RPL45; RPP2B; YPA1", "protein_names_uniprotkb": "Large ribosomal subunit protein P2B; 60S acidic ribosomal protein P2-beta; L12eIA; L45; P2B; YL44C; YP2beta; YPA1", "protein_names_refseq": "ribosomal protein P2 RPP2B", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR382W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 34, "publication_id_list": "10601260;11080154;11431471;11875433;14562095;14562106;15665377;16573688;17287358;17330950;17563356;18407956;1961721;19684113;19779198;19795423;19823750;20702584;21126336;22096102;22106047;22218487;23749301;2404943;24374639;24524803;2837476;33481703;33491328;7030402;8476850;9169867;9398162;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT16", "ec_number_list": "", "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0003735 structural constituent of ribosome;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0002182 cytoplasmic translational elongation", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P02400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02406-1", "uniprot_id": "RL28_YEAST", "mass": 16722.0, "length": 149, "protein_name": "Large ribosomal subunit protein uL15", "gene_name": "RPL28", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL15 RPL28", "refseq_ac": "NP_011412", "gene_names_uniprotkb": "RPL28; CYH2", "gene_names_refseq": "CYH2; RPL28", "protein_names_uniprotkb": "Large ribosomal subunit protein uL15; 60S ribosomal protein L28; L27a; L29; RP44; RP62; YL24", "protein_names_refseq": "60S ribosomal protein uL15 RPL28", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (sce:YGL103W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 18, "publication_id_list": "10601260;11701127;14976550;2104804;21109664;22096102;22106047;23749301;24374639;24524803;32597660;33481703;33491328;3553182;6304624;9169869;9290212;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU43", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P02406-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02557-1", "uniprot_id": "TBB_YEAST", "mass": 50923.0, "length": 457, "protein_name": "Tubulin beta chain", "gene_name": "TUB2", "organism": "Yeast", "refseq_name": "beta-tubulin", "refseq_ac": "NP_116616", "gene_names_uniprotkb": "TUB2", "gene_names_refseq": "ARM10; SHE8; TUB2", "protein_names_uniprotkb": "Tubulin beta chain; Beta-tubulin", "protein_names_refseq": "beta-tubulin", "tax_id": 559292, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); hypomyelinating leukodystrophy 6 (Disease Ontology:DOID:0060798); congenital fibrosis of the extraocular muscles (Disease Ontology:DOID:0080143); congenital fibrosis of the extraocular muscles 3A (Disease Ontology:DOID:0081017); torsion dystonia 4 (Disease Ontology:DOID:0090041); autosomal dominant isolated macrothrombocytopenia 1 (Disease Ontology:DOID:0090102); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 5 (Disease Ontology:DOID:0090135); complex cortical dysplasia with other brain malformations 6 (Disease Ontology:DOID:0090136); complex cortical dysplasia with other brain malformations 1 (Disease Ontology:DOID:0090137); tubulinopathy (Disease Ontology:DOID:0112227); Leber congenital amaurosis with early-onset deafness (Disease Ontology:DOID:0112240); congenital symmetric circumferential skin creases 1 (Disease Ontology:DOID:0112242); prostate cancer (Disease Ontology:DOID:10283); microcephaly (Disease Ontology:DOID:10907); Pick's disease (Disease Ontology:DOID:11870); facial paralysis (Disease Ontology:DOID:13934); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); malignant astrocytoma (Disease Ontology:DOID:3069); demyelinating disease (Disease Ontology:DOID:3213); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YFL037W); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18407956;2274023;23001566;24374639;28013290;33481703;33491328;6318115;6380751;7670463", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTJ3", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0045298 tubulin complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0090307 mitotic spindle assembly;GO:0090316 positive regulation of intracellular protein transport;GO:0007010 cytoskeleton organization;GO:0046677 response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02829-1", "uniprot_id": "HSP82_YEAST", "mass": 81406.0, "length": 709, "protein_name": "ATP-dependent molecular chaperone HSP82", "gene_name": "HSP82", "organism": "Yeast", "refseq_name": "Hsp90 family chaperone HSP82", "refseq_ac": "NP_015084", "gene_names_uniprotkb": "HSP82; HSP90", "gene_names_refseq": "HSP82; HSP90", "protein_names_uniprotkb": "ATP-dependent molecular chaperone HSP82; 82 kDa heat shock protein; Heat shock protein Hsp90 heat-inducible isoform", "protein_names_refseq": "Hsp90 family chaperone HSP82", "tax_id": 559292, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); varicocele (Disease Ontology:DOID:12337); colon cancer (Disease Ontology:DOID:219); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); pancreatitis (Disease Ontology:DOID:4989); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (sce:YPL240C); (R-SCE-1474151); (R-SCE-203615); (R-SCE-3371497); (R-SCE-3371511); (R-SCE-3371571); (R-SCE-5218920); (R-SCE-6798695); (R-SCE-844456); (R-SCE-8939211); (R-SCE-9009391)", "pathway_count": 11, "publication_count": 39, "publication_id_list": "10480867;10567567;10664467;10786835;10944121;12504007;12667448;14562095;14562106;14718169;14739935;16461354;16625188;17114002;18256191;18357975;18407956;19236053;19696785;20159553;21576760;24374639;2674684;33491328;6325446;7791797;7929182;8248264;8419347;8939862;9169875;9187656;9230303;9296388;9632755;9632766;9817749;9819421;9925731", "class_list": "", "function": "Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 27, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3D1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006970 response to osmotic stress;GO:0034605 cellular response to heat;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P02829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02992-1", "uniprot_id": "EFTU_YEAST", "mass": 47972.0, "length": 437, "protein_name": "Elongation factor Tu, mitochondrial", "gene_name": "TUF1", "organism": "Yeast", "refseq_name": "translation elongation factor Tu", "refseq_ac": "NP_014830", "gene_names_uniprotkb": "TUF1; TUFM", "gene_names_refseq": "TUF1", "protein_names_uniprotkb": "Elongation factor Tu, mitochondrial; 3.6.5.3; EF-Tu; tufM", "protein_names_refseq": "translation elongation factor Tu", "tax_id": 559292, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); combined oxidative phosphorylation deficiency 4 (Disease Ontology:DOID:0111494)", "pathway": " (sce:YOR187W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14576278;15695360;17287358;18407956;24374639;3301847;33481703;33491328;3905388;6353412;7593000;9169874", "class_list": "", "function": "G protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of mitochondrial ribosomes during protein biosynthesis (PubMed:3905388, PubMed:3301847). Participates in mitochondrial translation (PubMed:3905388, PubMed:3301847). In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA (PubMed:3905388). Has a higher affinity for GTP than GDP and may therefore recycle independently of a GEF (guanyl-nucleotide exchange factor) protein (PubMed:3301847, PubMed:15695360)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2P3", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070125 mitochondrial translational elongation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P02992-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02994-1", "uniprot_id": "EF1A_YEAST", "mass": 50033.0, "length": 458, "protein_name": "Elongation factor 1-alpha", "gene_name": "TEF1; TEF2", "organism": "Yeast", "refseq_name": "translation elongation factor EF-1 alpha", "refseq_ac": "NP_009676", "gene_names_uniprotkb": "TEF1; TEF2; P9513.7; YBR0913", "gene_names_refseq": "TEF2", "protein_names_uniprotkb": "Elongation factor 1-alpha; EF-1-alpha; Eukaryotic elongation factor 1A; Translation elongation factor 1A; eEF1A", "protein_names_refseq": "translation elongation factor EF-1 alpha", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 38 (Disease Ontology:DOID:0070068); developmental and epileptic encephalopathy 33 (Disease Ontology:DOID:0080463); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (sce:YBR118W); (sce:YPR080W); (R-SCE-156842); (R-SCE-3371511); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 6, "publication_count": 56, "publication_id_list": "10514524;10766739;10973948;11106763;11290701;11373622;12748053;12755685;14562095;14562106;15601860;15665377;16675455;17203074;17287358;17322287;18086883;18407956;19779198;19795423;19823750;20510667;20643906;21849502;22106047;22522802;23749301;24374639;24517342;25446118;26115316;26545399;28801462;2982849;3026912;3066688;32597660;33481703;33491328;34293820;36630955;38199565;3882705;6383821;6396088;7813418;7900426;7916691;8476932;9125210;9169875;9509572;9591785;9786872;9852145;9990316", "class_list": "", "function": "GTP-binding component of the eukaryotic elongation factor 1 complex (eEF1). In its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled by its guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) before binding another molecule of aminoacyl-tRNA. Required for nuclear export of aminoacyl-tRNAs. May also be involved in translational quality control by targeting cotranslationally damaged proteins to the proteasome. Also exhibits actin filament-binding and -bundling activities and is involved in cytoskeleton organization. Plays a role as a negative regulator of GCN2 kinase activity by inhibiting GCN2-mediated eIF-2-alpha phosphorylation in amino acid-repleted cells (PubMed:21849502)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQB6;Q7Z7U8;Q7Z8Q8;Q7Z8Q9", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005840 ribosome", "go_biological_process": "GO:0006409 tRNA export from nucleus;GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity;GO:0051017 actin filament bundle assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P02994-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03069-1", "uniprot_id": "GCN4_YEAST", "mass": 31310.0, "length": 281, "protein_name": "General control transcription factor GCN4", "gene_name": "GCN4", "organism": "Yeast", "refseq_name": "amino acid starvation-responsive transcription factor GCN4", "refseq_ac": "NP_010907", "gene_names_uniprotkb": "GCN4; AAS101; AAS3; ARG9", "gene_names_refseq": "AAS101; AAS3; ARG9; GCN4", "protein_names_uniprotkb": "General control transcription factor GCN4; Amino acid biosynthesis regulatory protein; General control protein GCN4", "protein_names_refseq": "amino acid starvation-responsive transcription factor GCN4", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL009C); (R-SCE-450341)", "pathway_count": 2, "publication_count": 41, "publication_id_list": "10549298;10712509;10733573;11331604;11390663;11896344;12101234;12455686;14648200;1473154;15087486;18407956;1891459;1939099;1948029;1986242;19940160;2204805;2277632;23749301;24374639;25079372;2676723;29628310;33122193;33481703;33491328;34965436;3516411;3530496;3532321;3678204;6387704;6433345;7664107;7862116;8336737;9169868;9488488;9582292;9837709", "class_list": "", "function": "Master transcriptional regulator that mediates the response to amino acid starvation (PubMed:11390663, PubMed:29628310). Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' in canonical nucleosome-depleted 5'-positioned promoters, and also within coding sequences and 3' non-coding regions (PubMed:11390663, PubMed:1473154, PubMed:1939099, PubMed:2204805, PubMed:2277632, PubMed:29628310, PubMed:3530496, PubMed:3532321, PubMed:3678204, PubMed:7664107). During nutrient starvation (low or poor amino acid, carbon or purine sources), it activates genes required for amino acid biosynthesis and transport, autophagy, cofactor biosynthesis and transport, mitochondrial transport, and additional downstream transcription factors (PubMed:10733573, PubMed:11390663, PubMed:1939099, PubMed:29628310, PubMed:7862116, PubMed:8336737). Activates transcription by recruiting multiple coactivators, including the mediator complex, the SAGA complex, and the SWI/SNF complex, to enable assembly of the pre-initiation complex at core promoters (PubMed:10549298, PubMed:19940160, PubMed:9488488)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLN9;P03068;Q70D88;Q70D91;Q70D96;Q70D99;Q70DA0;Q96UT3", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008652 amino acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P03069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03870-1", "uniprot_id": "FLP_YEAST", "mass": 48620.0, "length": 423, "protein_name": "Site-specific recombinase Flp", "gene_name": "FLP1", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FLP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Site-specific recombinase Flp; FLP; Protein Able", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "11090626;2040639;2211714;2254930;2832156;2974924;2995370;3104911;3316982;386282;6251374", "class_list": "", "function": "Part of the plasmid amplification system, which corrects any decrease in copy number caused by a rare missegregation event. Catalyzes the recombination between the large inverted repetitions of the 2-micron plasmid during plasmid replication. This recombination event changes the direction of one of the two replication forks in the bidirectionally replicating molecule, effectively resulting in multiple rounds of replication from a single initiation event. Binds specifically to the FLP recognition target (FRT) site where it induces DNA to bend. Three types of bend exist. Type I is approximately 60 degrees and results from 1 FLP molecule binding to 1 symmetry element. Type II is >144 degrees and results from FLP molecules binding to symmetry elements a and b. Type III is approximately 65 degrees and results from FLP molecules binding to symmetry elements b and c., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0009009 site-specific recombinase activity", "go_cellular_component": "", "go_biological_process": "GO:0042150 plasmid recombination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P03870-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03871-1", "uniprot_id": "REP1_YEAST", "mass": 43231.0, "length": 373, "protein_name": "Partitioning protein REP1", "gene_name": "REP1", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "REP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Partitioning protein REP1; Protein Baker; R1; Trans-acting factor B", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 14, "publication_id_list": "10791970;11244071;12177044;15169893;1672551;16966420;2197179;2832156;32597660;33491328;386282;6251374;9393716;9819432", "class_list": "", "function": "Part of the plasmid partitioning system, which ensures the equal distribution of replicated plasmid molecules to daughter cells. The plasmids exist as well-organized plasmid foci within the nucleus that stay together throughout the cell-cycle and act as entity during segregation, effetively reducing copy number to one. Plasmid partitioning requires the proteins REP1, REP2, and a cis-acting locus STB (REP3). REP1-REP2 stably associate with CSE4-containing chromatin at STB during S-phase, marking the locus with a centromeric tag, and thereby probably catching mitotic spindle microtubules to the plasmid cluster and coupling plasmid segregation to chromosome segregation. REP1-REP2 are required to recruit the cohesin complex to the STB locus for pairing of the replicated plasmid cluster, a prerequisite for successful plasmid segregation. REP1-REP2 also negatively regulate expression of site-specific recombinase FLP and of RAF1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q04137;Q07007", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0030543 2-micrometer plasmid partitioning", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P03871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03872-1", "uniprot_id": "REP2_YEAST", "mass": 33196.0, "length": 296, "protein_name": "Partitioning protein REP2", "gene_name": "REP2", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "REP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Partitioning protein REP2; Protein Charlie; R2; Trans-acting factor C", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 12, "publication_id_list": "10791970;11244071;12177044;16966420;18407956;22814378;2832156;33481703;33491328;6251374;9393716;9819432", "class_list": "", "function": "Part of the plasmid partitioning system, which ensures the equal distribution of replicated plasmid molecules to daughter cells. The plasmids exist as well-organized plasmid foci within the nucleus that stay together throughout the cell-cycle and act as entity during segregation, effetively reducing copy number to one. Plasmid partitioning requires the proteins REP1, REP2, and a cis-acting locus STB (REP3). REP1-REP2 stably associate with CSE4-containing chromatin at STB during S-phase, marking the locus with a centromeric tag, and thereby probably catching mitotic spindle microtubules to the plasmid cluster and coupling plasmid segregation to chromosome segregation. REP1-REP2 are required to recruit the cohesin complex to the STB locus for pairing of the replicated plasmid cluster, a prerequisite for successful plasmid segregation. REP1-REP2 also negatively regulate expression of site-specific recombinase FLP and of RAF1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0050821 protein stabilization;GO:0030543 2-micrometer plasmid partitioning", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P03872-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03873-1", "uniprot_id": "MBI2_YEAST", "mass": 49326.0, "length": 423, "protein_name": "Cytochrome b mRNA maturase bI2", "gene_name": "BI2", "organism": "Yeast", "refseq_name": "cytochrome b mRNA maturase bI2", "refseq_ac": "NP_009318", "gene_names_uniprotkb": "BI2", "gene_names_refseq": "BI2", "protein_names_uniprotkb": "Cytochrome b mRNA maturase bI2", "protein_names_refseq": "cytochrome b mRNA maturase bI2", "tax_id": 559292, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); ovarian carcinoma (Disease Ontology:DOID:4001); thyrotoxicosis (Disease Ontology:DOID:7997); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:Q0110)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11016843;24374639;6253454;7004642;8670880;9872396", "class_list": "", "function": "This protein is responsible for splicing and maturation of cytochrome b mRNA. Specifically, it may be responsible for the splicing specificity of the second intron., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7P383;Q9T2W1;Q9ZZW8", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0016491 oxidoreductase activity;GO:0004519 endonuclease activity;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P03873-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03877-1", "uniprot_id": "SCE3_YEAST", "mass": 47917.0, "length": 415, "protein_name": "Intron-encoded DNA endonuclease aI3", "gene_name": "AI3", "organism": "Yeast", "refseq_name": "intron-encoded DNA endonuclease aI3", "refseq_ac": "NP_009308", "gene_names_uniprotkb": "AI3; ENS3; I-SCEIII", "gene_names_refseq": "AI3", "protein_names_uniprotkb": "Intron-encoded DNA endonuclease aI3; DNA endonuclease I-SceIII; Intron-encoded endonuclease I-SceIII", "protein_names_refseq": "intron-encoded DNA endonuclease aI3", "tax_id": 559292, "disease": "", "pathway": " (sce:Q0060)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24374639;6254986;7797552;8112577;8367285;9872396", "class_list": "", "function": "Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with high specificity and cleaves the sequence 5'-GGTTTTGGTAACTATTTATTAC-3'., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7P044;Q35790;Q9ZZX3", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration;GO:0006314 intron homing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P03877-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03878-1", "uniprot_id": "SCE2_YEAST", "mass": 63311.0, "length": 556, "protein_name": "Intron-encoded DNA endonuclease aI4", "gene_name": "AI4", "organism": "Yeast", "refseq_name": "intron-encoded DNA endonuclease aI4", "refseq_ac": "NP_009307", "gene_names_uniprotkb": "AI4; ENS2; I-SCEII", "gene_names_refseq": "AI4", "protein_names_uniprotkb": "Intron-encoded DNA endonuclease aI4; DNA endonuclease I-SceII; Intron-encoded endonuclease I-SceII", "protein_names_refseq": "intron-encoded DNA endonuclease aI4", "tax_id": 559292, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:Q0065)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1310149;2172241;2216759;24374639;2536592;2536593;6254986;6285204;8352597;9872396", "class_list": "", "function": "Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break at the junction of the two exons a4-a5 of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-TTTGGTCACCCTGAAGTA-3'. The protein may acquire mRNA maturase activity, like the closely related bI4, through a single amino acid substitution Glu-362 to Lys or when present together with a mutant form of the imported mitochondrial leucyl-tRNA synthetase NAM2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7P354;Q02339;Q35798;Q9ZZX2", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration;GO:0006314 intron homing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P03878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03879-1", "uniprot_id": "MBI4_YEAST", "mass": 74580.0, "length": 638, "protein_name": "Intron-encoded RNA maturase bI4", "gene_name": "BI4", "organism": "Yeast", "refseq_name": "intron-encoded RNA maturase bI4", "refseq_ac": "NP_009316", "gene_names_uniprotkb": "BI4; SCBI4", "gene_names_refseq": "BI4", "protein_names_uniprotkb": "Intron-encoded RNA maturase bI4; RNA maturase SCbI4", "protein_names_refseq": "intron-encoded RNA maturase bI4", "tax_id": 559292, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); ovarian carcinoma (Disease Ontology:DOID:4001); thyrotoxicosis (Disease Ontology:DOID:7997); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:Q0120)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11142386;1310149;24374639;2560681;3284745;6253454;8352597;9872396", "class_list": "", "function": "Mitochondrial mRNA maturase required for splicing of intron 4 of the cytochrome b (COB) gene, containing its own coding sequence, and intron 4 in COX1, coding for the related homing endonuclease aI4. In vivo splicing requires in addition the imported mitochondrial leucyl-tRNA synthetase NAM2. Both proteins seem to stimulate the intrinsic ribozyme activity of intron bI4 through binding to and stabilizing specific secondary and tertiary structure elements in the RNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYH9;Q02324;Q9ZZW6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006397 mRNA processing;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0090615 mitochondrial mRNA processing;GO:0000372 Group I intron splicing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P03879-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03962-1", "uniprot_id": "PYRF_YEAST", "mass": 29240.0, "length": 267, "protein_name": "Orotidine 5'-phosphate decarboxylase", "gene_name": "URA3", "organism": "Yeast", "refseq_name": "orotidine-5'-phosphate decarboxylase", "refseq_ac": "NP_010893", "gene_names_uniprotkb": "URA3", "gene_names_refseq": "URA3", "protein_names_uniprotkb": "Orotidine 5'-phosphate decarboxylase; 4.1.1.23; OMP decarboxylase; OMPDCase; OMPdecase; UMP synthase; Uridine 5'-monophosphate synthase", "protein_names_refseq": "orotidine-5'-phosphate decarboxylase", "tax_id": 559292, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (sce:YEL021W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10681417;11278904;12872131;18407956;22814378;23749301;24374639;3023868;6092217;6315953;9169868", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLM7", "ec_number_list": "4.1.1.23", "go_molecular_function": "GO:0004590 orotidine-5'-phosphate decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006222 UMP biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P03962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03965-1", "uniprot_id": "CARB_YEAST", "mass": 123915.0, "length": 1118, "protein_name": "Carbamoyl phosphate synthase arginine-specific large chain", "gene_name": "CPA2", "organism": "Yeast", "refseq_name": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2", "refseq_ac": "NP_012643", "gene_names_uniprotkb": "CPA2; J2002", "gene_names_refseq": "CPA2", "protein_names_uniprotkb": "Carbamoyl phosphate synthase arginine-specific large chain; 6.3.4.16; 6.3.5.5; Ammonium-dependent carbamoyl phosphate synthetase; Arginine-specific carbamoyl phosphate synthetase, ammonia chain; CPS-A; CPSase-arg; CPSase; CPS; Carbamoyl phosphate synthase A; Glutamine-dependent carbamoyl phosphate synthetase", "protein_names_refseq": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2", "tax_id": 559292, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); hypertension (Disease Ontology:DOID:10763); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); vascular disease (Disease Ontology:DOID:178); hepatocellular carcinoma (Disease Ontology:DOID:684); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YJR109C); (R-SCE-70635)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "12392708;14562095;14562106;200419;205532;206535;206652;24374639;24909858;2689869;33481703;33491328;4594376;5856369;6358221;8626695;8641269", "class_list": "", "function": "Large subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, hydrogencarbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The large subunit (synthetase) binds the substrates ammonia (free or transferred from glutamine from the small subunit), hydrogencarbonate and ATP and carries out an ATP-coupled ligase reaction, activating hydrogencarbonate by forming carboxy phosphate which reacts with ammonia to form carbamoyl phosphate., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWS8", "ec_number_list": "6.3.4.16;6.3.5.5;2.1.3.2;3.5.1.2", "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005951 carbamoyl-phosphate synthase complex", "go_biological_process": "GO:0006526 L-arginine biosynthetic process;GO:0006221 pyrimidine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P03965-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04037-1", "uniprot_id": "COX4_YEAST", "mass": 17143.0, "length": 155, "protein_name": "Cytochrome c oxidase subunit 4, mitochondrial", "gene_name": "COX4", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit IV", "refseq_ac": "NP_011328", "gene_names_uniprotkb": "COX4; G1362", "gene_names_refseq": "COX4", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 4, mitochondrial; Cytochrome c oxidase polypeptide IV", "protein_names_refseq": "cytochrome c oxidase subunit IV", "tax_id": 559292, "disease": "hypertension (Disease Ontology:DOID:10763); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (sce:YGL187C); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10764779;10775262;11470436;1331058;17215247;17244705;17761666;24374639;3033605;30598554;30598556;33491328;6098449;6327686;7851399;9046087;9169869", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBN6;D6VTW7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:1990145 maintenance of translational fidelity;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P04037-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04039-1", "uniprot_id": "COX8_YEAST", "mass": 8907.0, "length": 78, "protein_name": "Cytochrome c oxidase subunit 8, mitochondrial", "gene_name": "COX8", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit VIII", "refseq_ac": "NP_013499", "gene_names_uniprotkb": "COX8; L8084.14", "gene_names_refseq": "COX8", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8, mitochondrial; Cytochrome c oxidase polypeptide VIII", "protein_names_refseq": "cytochrome c oxidase subunit VIII", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR395C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10764779;10775262;1331058;14562106;17322287;24374639;3023386;30598554;30598556;6327685;7851399;9169871", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ30", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P04039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04050-1", "uniprot_id": "RPB1_YEAST", "mass": 191612.0, "length": 1733, "protein_name": "DNA-directed RNA polymerase II subunit RPB1", "gene_name": "RPO21", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase II core subunit RPO21", "refseq_ac": "NP_010141", "gene_names_uniprotkb": "RPO21; D2150; RPB1; RPB220; SUA8", "gene_names_refseq": "RPB1; RPB220; RPO21; SIT1; SUA8", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB1; 2.7.7.6; DNA-directed RNA polymerase III largest subunit; RNA polymerase II subunit 1; RNA polymerase II subunit B1; RNA polymerase II subunit B220", "protein_names_refseq": "DNA-directed RNA polymerase II core subunit RPO21", "tax_id": 559292, "disease": "Cockayne syndrome (Disease Ontology:DOID:2962); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (sce:YDL140C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 16, "publication_count": 62, "publication_id_list": "10445027;10531363;10594013;11018013;11313498;11313499;11390638;11751637;11805306;11859374;12746495;12746498;12914699;12972617;14555478;14557538;14562095;14580350;14963322;15047695;15166235;15537538;15565157;15591044;15610738;15960978;16341226;16765890;17330950;17563356;18407956;19450536;19679665;19920177;20489023;20713510;20818391;20835241;21126336;21177495;22106047;22796944;23151482;23749301;23993092;24374639;25652824;27821475;28826505;30181345;31085683;32142654;32597660;33481703;33491328;3896517;7498765;7649444;8972577;9169867;9237170;9702190", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. In elongating Pol II, the lid loop (RPB1) appears to act as a wedge to drive apart the DNA and RNA strands at the upstream end of the transcription bubble and guide the RNA strand toward the RNA exit groove located near the base of the largely unstructured CTD domain of RPB1. The rudder loop (RPB1) interacts with single-stranded DNA after separation from the RNA strand, likely preventing reassociation with the exiting RNA. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw, formed by RPB5 and portions of RBP1. The jaws are thought to grab the incoming DNA template, mainly by RPB5 direct contacts to DNA., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 226, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VRK8;Q12364;Q92315", "ec_number_list": "2.7.7.6;2.7.11.23;5.6.2.3;3.1.-.-;2.7.7.7;3.1.11.-;2.7.11.22;2.3.2.27;2.1.1.56;3.1.3.16;3.6.4.-;2.3.1.48;3.4.19.12;5.2.1.8;5.6.2.4;2.7.7.50", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0010494 cytoplasmic stress granule;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0042789 mRNA transcription by RNA polymerase II;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 6.3, "record_id": "P04050-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04051-1", "uniprot_id": "RPC1_YEAST", "mass": 162301.0, "length": 1460, "protein_name": "DNA-directed RNA polymerase III subunit RPC1", "gene_name": "RPO31", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase III core subunit RPO31", "refseq_ac": "NP_014759", "gene_names_uniprotkb": "RPO31; O3254; RPC160; RPC1; YOR3254C", "gene_names_refseq": "RPC160; RPC1; RPO31", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC1; 2.7.7.6; DNA-directed RNA polymerase III largest subunit; RNA polymerase III subunit C160; RNA polymerase III subunit C1", "protein_names_refseq": "DNA-directed RNA polymerase III core subunit RPO31", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 7 (Disease Ontology:DOID:0060794); Wiedemann-Rautenstrauch syndrome (Disease Ontology:DOID:0081333)", "pathway": " (sce:YOR116C); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10384303;14562095;14562106;16818233;22814378;24374639;32597660;33481703;33491328;3896517;8164651;8599945;8904341;9169874;9200815", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2H5", "ec_number_list": "2.7.7.6", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P04051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04147-1", "uniprot_id": "PABP_YEAST", "mass": 64344.0, "length": 577, "protein_name": "Polyadenylate-binding protein, cytoplasmic and nuclear", "gene_name": "PAB1", "organism": "Yeast", "refseq_name": "polyadenylate-binding protein", "refseq_ac": "NP_011092", "gene_names_uniprotkb": "PAB1", "gene_names_refseq": "PAB1", "protein_names_uniprotkb": "Polyadenylate-binding protein, cytoplasmic and nuclear; ARS consensus-binding protein ACBP-67; PABP; Poly(A)-binding protein; Polyadenylate tail-binding protein", "protein_names_refseq": "polyadenylate-binding protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YER165W); (R-SCE-156827); (R-SCE-429947); (R-SCE-72649); (R-SCE-975956); (R-SCE-975957)", "pathway_count": 6, "publication_count": 55, "publication_id_list": "10357826;10944120;11279042;11741542;11889048;11940585;11971964;12923185;14562106;15169912;15337765;15356266;15525991;15630021;15769879;1675426;16809762;17322287;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22106047;22218487;23749301;23865587;24326073;24374639;2565532;2673535;30516470;32027465;32597660;3313012;33481703;33491328;3518950;3537727;7557393;8127652;8413212;9003792;9169868;9193001;9199303;9223284;9256432;9298649;9418852;9702200;9784497;9819425", "class_list": "", "function": "Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, interacts with the nuclear cleavage factor IA (CFIA), which is required for both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. Regulates PAN activity via interaction with the stimulator PAN3 or the inhibitor PBP1. In the cytoplasm, affects both translation and mRNA decay. Stimulates translation by interaction with translation initiation factor eIF4G, a subunit of the cap-binding complex eIF4F, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. Also regulates translation termination by recruiting eukaryotic release factor 3 (eRF3). Interaction with eRF3 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN. Loss of PAB1 from the mRNP after deadenylation triggers mRNA degradation. Inhibits the major cytoplasmic mRNA deadenylase CCR4-NOT complex. Is also associated peripherally with COPI vesicles through its interaction with ARF1, and this is required for correct localization of the asymmetrically distributed ASH1 mRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM73", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008428 ribonuclease inhibitor activity;GO:1990841 promoter-specific chromatin binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005840 ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006446 regulation of translational initiation;GO:0051028 mRNA transport;GO:0031124 mRNA 3'-end processing;GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "P04147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04385-1", "uniprot_id": "GAL1_YEAST", "mass": 57944.0, "length": 528, "protein_name": "Galactokinase", "gene_name": "GAL1", "organism": "Yeast", "refseq_name": "galactokinase", "refseq_ac": "NP_009576", "gene_names_uniprotkb": "GAL1; YBR0302", "gene_names_refseq": "GAL1", "protein_names_uniprotkb": "Galactokinase; 2.7.1.6; Galactose kinase", "protein_names_refseq": "galactokinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR020W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12106903;1317007;13495476;14144;16115868;18407956;19779198;200486;22814378;24374639;2656659;33491328;3886158;6092912;6715281;7813418;8091864", "class_list": "", "function": "Galactokinase is a key enzyme in the galactose metabolism where it catalyzes the conversion of alpha-D-galactose to galactose 1-phosphate (PubMed:12106903, PubMed:13495476, PubMed:14144). Can also induce the transcription of the yeast GAL genes in response to the organism being challenged with galactose as the sole source of carbon (PubMed:1317007, PubMed:2656659). Its striking amino acid sequence similarity to GAL3 might explain its GAL3-like induction activity (PubMed:1317007, PubMed:2656659)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ22", "ec_number_list": "2.7.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0004335 galactokinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose;GO:0006012 galactose metabolic process;GO:0046835 carbohydrate phosphorylation;GO:0000411 positive regulation of transcription by galactose", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P04385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04386-1", "uniprot_id": "GAL4_YEAST", "mass": 99403.0, "length": 881, "protein_name": "Regulatory protein GAL4", "gene_name": "GAL4", "organism": "Yeast", "refseq_name": "galactose-responsive transcription factor GAL4", "refseq_ac": "NP_015076", "gene_names_uniprotkb": "GAL4", "gene_names_refseq": "GAL4; GAL81", "protein_names_uniprotkb": "Regulatory protein GAL4", "protein_names_refseq": "galactose-responsive transcription factor GAL4", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL248C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10360183;10805731;11478912;14562106;1557122;1557129;1557130;15797387;17467953;18407956;18611375;18931787;1961715;19779198;2021614;2107541;2265711;23749301;24374639;3299106;33481703;33491328;33502312;6366516;8756647;9169875;9660972", "class_list": "", "function": "This protein is a positive regulator for the gene expression of the galactose-induced genes such as GAL1, GAL2, GAL7, GAL10, and MEL1 which code for the enzymes used to convert galactose to glucose. It recognizes a 17 base pair sequence in (5'-CGGRNNRCYNYNCNCCG-3') the upstream activating sequence (UAS-G) of these genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3C3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006012 galactose metabolic process;GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P04386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04387-1", "uniprot_id": "GAL80_YEAST", "mass": 48323.0, "length": 435, "protein_name": "Galactose/lactose metabolism regulatory protein GAL80", "gene_name": "GAL80", "organism": "Yeast", "refseq_name": "transcription regulator GAL80", "refseq_ac": "NP_013661", "gene_names_uniprotkb": "GAL80; YM9827.01; YM9958.12", "gene_names_refseq": "GAL80", "protein_names_uniprotkb": "Galactose/lactose metabolism regulatory protein GAL80", "protein_names_refseq": "transcription regulator GAL80", "tax_id": 559292, "disease": "", "pathway": " (sce:YML051W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;19779198;1985957;23749301;24374639;32597660;33481703;33491328;6393054;9169872", "class_list": "", "function": "This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It binds to GAL4 and so blocks transcriptional activation by it, in the absence of an inducing sugar., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZC4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0019210 kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0042326 negative regulation of phosphorylation;GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P04387-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04397-1", "uniprot_id": "GAL10_YEAST", "mass": 78195.0, "length": 699, "protein_name": "Bifunctional protein GAL10", "gene_name": "GAL10", "organism": "Yeast", "refseq_name": "bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase", "refseq_ac": "NP_009575", "gene_names_uniprotkb": "GAL10; YBR0301", "gene_names_refseq": "GAL10", "protein_names_uniprotkb": "Bifunctional protein GAL10; Galactose mutarotase; Galactowaldenase", "protein_names_refseq": "bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase", "tax_id": 559292, "disease": "galactose epimerase deficiency (Disease Ontology:DOID:0111458); thrombocytopenia (Disease Ontology:DOID:1588); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (sce:YBR019C); (R-SCE-70370)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "19779198;24374639;24440502;2851900;6092912;6715281;7762304;7813418;8091864", "class_list": "", "function": "Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ21;Q05765", "ec_number_list": "5.1.3.2;5.1.3.3", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0003978 UDP-glucose 4-epimerase activity;GO:0004034 aldose 1-epimerase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0005996 monosaccharide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04397-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04456-1", "uniprot_id": "RL25_YEAST", "mass": 15758.0, "length": 142, "protein_name": "Large ribosomal subunit protein uL23", "gene_name": "RPL25", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL23 RPL25", "refseq_ac": "NP_014514", "gene_names_uniprotkb": "RPL25", "gene_names_refseq": "RPL25", "protein_names_uniprotkb": "Large ribosomal subunit protein uL23; 60S ribosomal protein L25; RP16L; YL25; YP42'", "protein_names_refseq": "60S ribosomal protein uL23 RPL25", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL127W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 25, "publication_id_list": "10601260;11701127;11875433;14976550;1544921;15542864;17287358;18407956;19795423;19823750;21109664;21126336;22096102;22106047;22814378;23749301;24374639;24524803;32597660;33481703;33491328;6091033;8896265;9169874;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL23 is a major component of the universal docking site for these factors at the polypeptide exit tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1U1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P04456-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04710-1", "uniprot_id": "ADT1_YEAST", "mass": 34121.0, "length": 309, "protein_name": "ADP/ATP translocase 1", "gene_name": "AAC1", "organism": "Yeast", "refseq_name": "ADP/ATP carrier protein AAC1", "refseq_ac": "NP_013772", "gene_names_uniprotkb": "AAC1; YM9796.09C", "gene_names_refseq": "AAC1", "protein_names_uniprotkb": "ADP/ATP translocase 1; ADP,ATP carrier protein 1; ANT 1; Adenine nucleotide translocator 1", "protein_names_refseq": "ADP/ATP carrier protein AAC1", "tax_id": 559292, "disease": "mitochondrial DNA depletion syndrome 12a (Disease Ontology:DOID:0080130); mitochondrial DNA depletion syndrome 12b (Disease Ontology:DOID:0080335); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111517); Alzheimer's disease (Disease Ontology:DOID:10652); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); epilepsy (Disease Ontology:DOID:1826); mitochondrial myopathy (Disease Ontology:DOID:699); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YMR056C); (R-SCE-1268020); (R-SCE-166187); (R-SCE-83936); (R-SCE-9837999)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12740376;1651171;17761666;2167309;24374639;3023860;9169872", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:2167309). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZN1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005471 ATP:ADP antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0046902 regulation of mitochondrial membrane permeability;GO:0015886 heme transport;GO:0006783 heme biosynthetic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04710-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04786-1", "uniprot_id": "TOP1_YEAST", "mass": 89995.0, "length": 769, "protein_name": "DNA topoisomerase 1", "gene_name": "TOP1", "organism": "Yeast", "refseq_name": "DNA topoisomerase 1", "refseq_ac": "NP_014637", "gene_names_uniprotkb": "TOP1; MAK1", "gene_names_refseq": "MAK17; MAK1; TOP1", "protein_names_uniprotkb": "DNA topoisomerase 1; 5.6.2.1; DNA topoisomerase I; Maintenance of killer protein 1", "protein_names_refseq": "DNA topoisomerase 1", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YOL006C); (R-SCE-4615885)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "14562106;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;21725298;22218487;23749301;24374639;2542938;2547758;2989818;30516470;32597660;33481703;33491328;8747458;9169874", "class_list": "", "function": "Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W261", "ec_number_list": "5.6.2.1;2.3.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005694 chromosome", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0006260 DNA replication;GO:0007076 mitotic chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P04786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04802-1", "uniprot_id": "SYDC_YEAST", "mass": 63516.0, "length": 557, "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "DPS1", "organism": "Yeast", "refseq_name": "aspartate--tRNA ligase DPS1", "refseq_ac": "NP_013083", "gene_names_uniprotkb": "DPS1; APS1; APS; L1295", "gene_names_refseq": "DPS1", "protein_names_uniprotkb": "Aspartate--tRNA ligase, cytoplasmic; 6.1.1.12; AspRS; Aspartyl-tRNA synthetase", "protein_names_refseq": "aspartate--tRNA ligase DPS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL018C)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "14562106;15665377;17287358;17330950;17563356;18407956;19779198;19795423;19823750;2021621;2047877;20702584;21126336;21177495;22218487;23749301;24374639;32597660;3278298;33229814;33481703;33491328;3513127;3902099;8248175;8313877;8810043;9046100;9169871;9298649", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXY6", "ec_number_list": "6.1.1.12", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0004815 aspartate-tRNA ligase activity;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0006422 aspartyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P04802-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04806-1", "uniprot_id": "HXKA_YEAST", "mass": 53738.0, "length": 485, "protein_name": "Hexokinase-1", "gene_name": "HXK1", "organism": "Yeast", "refseq_name": "hexokinase 1", "refseq_ac": "NP_116711", "gene_names_uniprotkb": "HXK1; HKA", "gene_names_refseq": "HXK1", "protein_names_uniprotkb": "Hexokinase-1; 2.7.1.1; Hexokinase PI; Hexokinase-A", "protein_names_refseq": "hexokinase 1", "tax_id": 559292, "disease": "congenital nonspherocytic hemolytic anemia 5 (Disease Ontology:DOID:0051006); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); retinitis pigmentosa 92 (Disease Ontology:DOID:0061107); retinitis pigmentosa 79 (Disease Ontology:DOID:0061108); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); Charcot-Marie-Tooth disease type 4G (Disease Ontology:DOID:0110196); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); gestational diabetes (Disease Ontology:DOID:11714); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); hyperinsulinism (Disease Ontology:DOID:2018); anemia (Disease Ontology:DOID:2355); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YFR053C); (R-SCE-170822); (R-SCE-446205); (R-SCE-6798695); (R-SCE-70171)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "11875433;14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;23749301;24374639;3003701;3131329;32597660;332086;33481703;33491328;36302925;3908224;7001031;7670463;8686379", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:332086). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:332086)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTT6", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0004396 hexokinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process;GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P04806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04807-1", "uniprot_id": "HXKB_YEAST", "mass": 53942.0, "length": 486, "protein_name": "Hexokinase-2", "gene_name": "HXK2", "organism": "Yeast", "refseq_name": "hexokinase 2", "refseq_ac": "NP_011261", "gene_names_uniprotkb": "HXK2; HEX1; HKB; NRB486", "gene_names_refseq": "HEX1; HKB; HXK2; SCI2", "protein_names_uniprotkb": "Hexokinase-2; 2.7.1.1; Hexokinase PII; Hexokinase-B", "protein_names_refseq": "hexokinase 2", "tax_id": 559292, "disease": "congenital nonspherocytic hemolytic anemia 5 (Disease Ontology:DOID:0051006); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); retinitis pigmentosa 92 (Disease Ontology:DOID:0061107); retinitis pigmentosa 79 (Disease Ontology:DOID:0061108); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); Charcot-Marie-Tooth disease type 4G (Disease Ontology:DOID:0110196); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); gestational diabetes (Disease Ontology:DOID:11714); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); hyperinsulinism (Disease Ontology:DOID:2018); anemia (Disease Ontology:DOID:2355); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YGL253W); (R-SCE-170822); (R-SCE-446205); (R-SCE-6798695); (R-SCE-70171)", "pathway_count": 5, "publication_count": 35, "publication_id_list": "10428955;11170432;11875433;14562106;15665377;17287358;18407956;19684113;19779198;20702584;21126336;21177495;22289182;23066030;23273919;23749301;24374639;3003701;30516470;32597660;332086;33232441;33481703;33491328;355643;36302925;3905511;7737086;8286332;8322518;8972578;9047292;9169869;9566913;9718324", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:332086). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:332086)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV82;Q05838", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0004396 hexokinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process;GO:2001234 negative regulation of apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P04807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04817-1", "uniprot_id": "CAN1_YEAST", "mass": 65785.0, "length": 590, "protein_name": "Arginine permease CAN1", "gene_name": "CAN1", "organism": "Yeast", "refseq_name": "arginine permease CAN1", "refseq_ac": "NP_010851", "gene_names_uniprotkb": "CAN1", "gene_names_refseq": "CAN1", "protein_names_uniprotkb": "Arginine permease CAN1; Canavanine resistance protein 1", "protein_names_refseq": "arginine permease CAN1", "tax_id": 559292, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374)", "pathway": " (sce:YEL063C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10654085;11746604;12100990;14551254;15665377;17563356;19684113;19779198;20702584;21223946;21880895;23749301;24374639;28228255;32597660;3327612;33481703;33491328;34965436;37005249;3900064;8436127;9169868;9231419;9544242", "class_list": "", "function": "High-affinity permease for arginine., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLI7", "ec_number_list": "", "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0015802 basic amino acid transport;GO:0055085 transmembrane transport;GO:0003333 amino acid transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P04817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04819-1", "uniprot_id": "DNLI1_YEAST", "mass": 84828.0, "length": 755, "protein_name": "DNA ligase 1", "gene_name": "CDC9", "organism": "Yeast", "refseq_name": "DNA ligase (ATP) CDC9", "refseq_ac": "NP_010117", "gene_names_uniprotkb": "CDC9", "gene_names_refseq": "CDC9; MMS8", "protein_names_uniprotkb": "DNA ligase 1; 6.5.1.1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1", "protein_names_refseq": "DNA ligase (ATP) CDC9", "tax_id": 559292, "disease": "immunodeficiency 96 (Disease Ontology:DOID:0061066); cancer (Disease Ontology:DOID:162); primary immunodeficiency disease (Disease Ontology:DOID:612); inherited metabolic disorder (Disease Ontology:DOID:655); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (sce:YDL164C); (R-SCE-110362); (R-SCE-5358565); (R-SCE-5358606); (R-SCE-69183)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "10531002;14562106;17287358;17322287;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;30516470;32597660;33481703;33491328;3909103;8483449;9169867", "class_list": "", "function": "DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. The mitochondrial form is required for mitochondrial DNA maintenance but is non-essential while the nuclear form is essential for cell viability., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRI7;Q12736", "ec_number_list": "6.5.1.1;2.7.7.7", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006273 lagging strand elongation;GO:0000278 mitotic cell cycle;GO:0006310 DNA recombination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P04819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04821-1", "uniprot_id": "CDC25_YEAST", "mass": 179092.0, "length": 1589, "protein_name": "Cell division control protein 25", "gene_name": "CDC25", "organism": "Yeast", "refseq_name": "Ras family guanine nucleotide exchange factor CDC25", "refseq_ac": "NP_013413", "gene_names_uniprotkb": "CDC25; CTN1; L2142.6", "gene_names_refseq": "CDC25; CTN1", "protein_names_uniprotkb": "Cell division control protein 25", "protein_names_refseq": "Ras family guanine nucleotide exchange factor CDC25", "tax_id": 559292, "disease": "gingival fibromatosis (Disease Ontology:DOID:0060466); Noonan syndrome 4 (Disease Ontology:DOID:0060582); Noonan syndrome 9 (Disease Ontology:DOID:0060587); prostate cancer (Disease Ontology:DOID:10283); atrial heart septal defect (Disease Ontology:DOID:1882); brain ischemia (Disease Ontology:DOID:2316); Noonan syndrome (Disease Ontology:DOID:3490); cerebral infarction (Disease Ontology:DOID:3526); cervical cancer (Disease Ontology:DOID:4362); pulmonary valve stenosis (Disease Ontology:DOID:6420)", "pathway": " (sce:YLR310C); (R-SCE-354192); (R-SCE-392517)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10529198;14562106;15665377;17330950;17563356;18407956;19779198;19795423;19823750;2017169;20489023;20702584;21126336;2176715;23749301;24374639;3011405;30516470;3070351;32597660;33229814;3329037;33481703;33491328;3545497;9169871", "class_list": "", "function": "Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 24, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 24, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 24, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 69, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "D6VYV4", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051301 cell division;GO:0007265 Ras protein signal transduction;GO:0007089 traversing start control point of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P04821-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04840-1", "uniprot_id": "VDAC1_YEAST", "mass": 30428.0, "length": 283, "protein_name": "Non-selective voltage-gated ion channel 1", "gene_name": "POR1", "organism": "Yeast", "refseq_name": "porin POR1", "refseq_ac": "NP_014343", "gene_names_uniprotkb": "POR1; N2441; OMP2; VDAC1; YNL2441C", "gene_names_refseq": "OMP2; POR1", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel 1; Outer mitochondrial membrane protein porin 1; VDAC-1; Voltage-dependent anion-selective channel protein 1", "protein_names_refseq": "porin POR1", "tax_id": 559292, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YNL055C); (R-SCE-5205685); (R-SCE-70268)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "17761666;18407956;19779198;20702584;21126336;21987634;22814378;2408884;24374639;2442148;2478533;30516470;32597660;33481703;33491328;38065946;7499333;8533472;9169873;9435273", "class_list": "", "function": "Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids., [UniProtKB, PubMed]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane (PubMed:9435273). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:9435273). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:9435273). Is the major permeability factor of the mitochondrial outer membrane (PubMed:9435273)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1C3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0017128 phospholipid scramblase activity;GO:0015288 porin activity;GO:0008308 voltage-gated monoatomic anion channel activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space;GO:0046930 pore complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0006811 monoatomic ion transport;GO:0006915 apoptotic process;GO:0045332 phospholipid translocation;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P04840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04911-1", "uniprot_id": "H2A1_YEAST", "mass": 13989.0, "length": 132, "protein_name": "Histone H2A.1", "gene_name": "HTA1", "organism": "Yeast", "refseq_name": "histone H2A", "refseq_ac": "NP_010511", "gene_names_uniprotkb": "HTA1; H2A1; SPT11; YD9934.10", "gene_names_refseq": "H2A1; HTA1; SPT11", "protein_names_uniprotkb": "Histone H2A.1", "protein_names_refseq": "histone H2A", "tax_id": 559292, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); liver benign neoplasm (Disease Ontology:DOID:916); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (sce:YDR225W); (R-SCE-2299718); (R-SCE-3214858)", "pathway_count": 3, "publication_count": 35, "publication_id_list": "10082517;10642555;11140636;11545749;11566884;11875433;12915400;15458641;15607975;15610740;15610741;15781691;16299494;16598039;19683497;19795423;20190278;21212735;2201907;22156209;22218487;22389435;23749301;24352239;24374639;25252977;2848829;29769606;32597660;32933557;33491328;33502312;7041122;7885847;9169867", "class_list": "", "function": "Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSK7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006325 chromatin organization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P04911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04912-1", "uniprot_id": "H2A2_YEAST", "mass": 13989.0, "length": 132, "protein_name": "Histone H2A.2", "gene_name": "HTA2", "organism": "Yeast", "refseq_name": "histone H2A", "refseq_ac": "NP_009552", "gene_names_uniprotkb": "HTA2; H2A2; YBL0103", "gene_names_refseq": "H2A2; HTA2", "protein_names_uniprotkb": "Histone H2A.2", "protein_names_refseq": "histone H2A", "tax_id": 559292, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (sce:YBL003C); (R-SCE-2299718); (R-SCE-3214858)", "pathway_count": 3, "publication_count": 35, "publication_id_list": "10082517;11140636;11545749;12915400;14562106;15458641;15607975;15610740;15610741;15665377;16292314;16299494;16598039;16940359;17106258;17322287;18086883;18407956;19795423;21212735;22389435;23749301;24352239;24374639;25252977;29769606;31804179;32597660;32933557;33491328;33502312;39601790;7041122;7813418;8091860", "class_list": "", "function": "Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPZ9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006325 chromatin organization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P04912-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05030-1", "uniprot_id": "PMA1_YEAST", "mass": 99619.0, "length": 918, "protein_name": "Plasma membrane ATPase 1", "gene_name": "PMA1", "organism": "Yeast", "refseq_name": "H(+)-exporting P2-type ATPase PMA1", "refseq_ac": "NP_011507", "gene_names_uniprotkb": "PMA1", "gene_names_refseq": "KTI10; PMA1", "protein_names_uniprotkb": "Plasma membrane ATPase 1; 7.1.2.1; Proton pump 1", "protein_names_refseq": "H(+)-exporting P2-type ATPase PMA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL008C)", "pathway_count": 1, "publication_count": 38, "publication_id_list": "1187543;11875433;14557538;14562106;15665377;16342953;16510118;16847258;17287358;17330950;17563356;17932035;1831768;18407956;19684113;19779198;19795423;19797769;19823750;20702584;21126336;2136852;22106047;22218487;23749301;24374639;28727280;28790206;2901955;29254995;3005867;30516470;32597660;33481703;33491328;8943257;9169869;9414109", "class_list": "", "function": "The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUC9", "ec_number_list": "7.1.2.1", "go_molecular_function": "GO:0008553 P-type proton-exporting transporter activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0032126 eisosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0055085 transmembrane transport;GO:0051453 regulation of intracellular pH;GO:1902600 proton transmembrane transport;GO:0120029 proton export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P05030-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05066-1", "uniprot_id": "PHR_YEAST", "mass": 66274.0, "length": 565, "protein_name": "Deoxyribodipyrimidine photo-lyase, mitochondrial", "gene_name": "PHR1", "organism": "Yeast", "refseq_name": "deoxyribodipyrimidine photo-lyase PHR1", "refseq_ac": "NP_015031", "gene_names_uniprotkb": "PHR1", "gene_names_refseq": "PHR1", "protein_names_uniprotkb": "Deoxyribodipyrimidine photo-lyase, mitochondrial; 4.1.99.3; DNA photolyase; Photoreactivating enzyme", "protein_names_refseq": "deoxyribodipyrimidine photo-lyase PHR1", "tax_id": 559292, "disease": "delayed sleep phase syndrome (Disease Ontology:DOID:0111141); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (sce:YOR386W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;15721603;21177495;24374639;3000886;3316199;3906569;8344951;9169874", "class_list": "", "function": "Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W379", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0071949 FAD binding;GO:0003904 deoxyribodipyrimidine photo-lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032922 circadian regulation of gene expression;GO:0043153 entrainment of circadian clock by photoperiod;GO:0000719 photoreactive repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P05066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05150-1", "uniprot_id": "OTC_YEAST", "mass": 37845.0, "length": 338, "protein_name": "Ornithine carbamoyltransferase", "gene_name": "ARG3", "organism": "Yeast", "refseq_name": "ornithine carbamoyltransferase", "refseq_ac": "NP_012447", "gene_names_uniprotkb": "ARG3; J0924", "gene_names_refseq": "ARG3", "protein_names_uniprotkb": "Ornithine carbamoyltransferase; 2.1.3.3; OTCase; Ornithine transcarbamylase", "protein_names_refseq": "ornithine carbamoyltransferase", "tax_id": 559292, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); cholestasis (Disease Ontology:DOID:13580); hepatocellular carcinoma (Disease Ontology:DOID:684); ornithine carbamoyltransferase deficiency (Disease Ontology:DOID:9271); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YJL088W); (R-SCE-1268020); (R-SCE-70635)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12679340;14562106;22814378;24374639;3038540;33481703;33491328;3915770;7483841;8641269", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW96", "ec_number_list": "2.1.3.3;3.4.24.-;1.16.3.1", "go_molecular_function": "GO:0004585 ornithine carbamoyltransferase activity;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0019240 citrulline biosynthetic process;GO:0006526 L-arginine biosynthetic process;GO:0042450 L-arginine biosynthetic process via ornithine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P05150-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05317-1", "uniprot_id": "RLA0_YEAST", "mass": 33717.0, "length": 312, "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "RPP0", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL10 RPP0", "refseq_ac": "NP_013444", "gene_names_uniprotkb": "RPP0; L10E; L8300.8; RPA0; RPL10E; RPLA0", "gene_names_refseq": "RPL10E; RPP0", "protein_names_uniprotkb": "Large ribosomal subunit protein uL10; 60S acidic ribosomal protein P0; A0; L10e", "protein_names_refseq": "60S ribosomal protein uL10 RPP0", "tax_id": 559292, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (sce:YLR340W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 23, "publication_id_list": "15286401;16573688;17287358;17330950;18407956;19779198;19795423;19823750;21109664;21126336;22096102;22106047;23749301;2404943;24374639;24524803;2681177;3287327;33481703;33491328;9169871;9559554;9843429", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYX8", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030686 90S preribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P05317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05318-1", "uniprot_id": "RLA1_YEAST", "mass": 10908.0, "length": 106, "protein_name": "Large ribosomal subunit protein P1A", "gene_name": "RPP1A", "organism": "Yeast", "refseq_name": "ribosomal protein P1 RPP1A", "refseq_ac": "NP_010202", "gene_names_uniprotkb": "RPP1A; L12EIIA; RPA1; RPLA1", "gene_names_refseq": "RPLA1; RPP1A", "protein_names_uniprotkb": "Large ribosomal subunit protein P1A; 60S acidic ribosomal protein P1-alpha; A1; L12eIIA; P1A; YP1alpha", "protein_names_refseq": "ribosomal protein P1 RPP1A", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (sce:YDL081C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 26, "publication_id_list": "10601260;11431471;11875433;14562095;16573688;17322287;17330950;18407956;19684113;19779198;19795423;19823750;22096102;22218487;23749301;2404943;24374639;24524803;2662969;3287328;33481703;33491328;8476850;9169867;9398162;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRR8", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0030295 protein kinase activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006414 translational elongation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P05318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05319-1", "uniprot_id": "RLA2_YEAST", "mass": 10746.0, "length": 106, "protein_name": "Large ribosomal subunit protein P2A", "gene_name": "RPP2A", "organism": "Yeast", "refseq_name": "ribosomal protein P2 RPP2A", "refseq_ac": "NP_014603", "gene_names_uniprotkb": "RPP2A; L12EIB; RPA2; RPL44; RPLA2", "gene_names_refseq": "RPL44; RPLA2; RPP2A", "protein_names_uniprotkb": "Large ribosomal subunit protein P2A; 60S acidic ribosomal protein P2-alpha; A2; L12eIB; L44; P2A; YP2alpha", "protein_names_refseq": "ribosomal protein P2 RPP2A", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL039W)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10525165;10601260;11431471;14562095;14562106;16573688;17287358;17322287;17330950;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22096102;22106047;22218487;23749301;2404943;24374639;24524803;2837476;30516470;3287329;33481703;33491328;8476850;9169874;9398162;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W227", "ec_number_list": "", "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0002182 cytoplasmic translational elongation", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P05319-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05373-1", "uniprot_id": "HEM2_YEAST", "mass": 37740.0, "length": 342, "protein_name": "Delta-aminolevulinic acid dehydratase", "gene_name": "HEM2", "organism": "Yeast", "refseq_name": "porphobilinogen synthase HEM2", "refseq_ac": "NP_011475", "gene_names_uniprotkb": "HEM2", "gene_names_refseq": "HEM2; OLE4; SLU1", "protein_names_uniprotkb": "Delta-aminolevulinic acid dehydratase; 4.2.1.24; ALADH; Porphobilinogen synthase", "protein_names_refseq": "porphobilinogen synthase HEM2", "tax_id": 559292, "disease": "sickle cell anemia (Disease Ontology:DOID:10923); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); porphyria cutanea tarda (Disease Ontology:DOID:3132); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (sce:YGL040C); (R-SCE-189451); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10386874;10739915;11513881;11545591;14562106;17322287;18407956;22814378;24374639;2445751;33481703;33491328;9169869;9234674;9406553", "class_list": "", "function": "Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU99", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004655 porphobilinogen synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P05373-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05374-1", "uniprot_id": "CHO2_YEAST", "mass": 101204.0, "length": 869, "protein_name": "Phosphatidylethanolamine N-methyltransferase", "gene_name": "CHO2", "organism": "Yeast", "refseq_name": "phosphatidylethanolamine N-methyltransferase", "refseq_ac": "NP_011673", "gene_names_uniprotkb": "CHO2; G6673; PEM1", "gene_names_refseq": "CHO2; PEM1", "protein_names_uniprotkb": "Phosphatidylethanolamine N-methyltransferase; 2.1.1.17; Choline-requiring protein 2; PE methyltransferase; PEAMT; PEMT", "protein_names_refseq": "phosphatidylethanolamine N-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR157W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562095;14562106;15258140;1650774;16847258;17563356;1954254;19779198;2198947;22001639;22814378;23749301;24374639;2445736;2684666;30377154;3066687;32597660;33481703;33491328;6759124;6988218;8585325;9169869", "class_list": "", "function": "Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME). Preferentially converts di-C16:1 substrates., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUT7", "ec_number_list": "2.1.1.17;2.1.1.71", "go_molecular_function": "GO:0004608 phosphatidylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006656 phosphatidylcholine biosynthetic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P05374-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05375-1", "uniprot_id": "PLMT_YEAST", "mass": 23150.0, "length": 206, "protein_name": "Phosphatidyl-N-methylethanolamine N-methyltransferase", "gene_name": "OPI3", "organism": "Yeast", "refseq_name": "bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase", "refseq_ac": "NP_012607", "gene_names_uniprotkb": "OPI3; J1824; PEM2", "gene_names_refseq": "OPI3; PEM2", "protein_names_uniprotkb": "Phosphatidyl-N-methylethanolamine N-methyltransferase; 2.1.1.17; 2.1.1.71; Overproducer of inositol protein 3; PLMT; Phospholipid methyltransferase", "protein_names_refseq": "bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase", "tax_id": 559292, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508)", "pathway": " (sce:YJR073C); (R-SCE-1483191)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14562095;14562106;14576278;1650774;17322287;1954254;2198947;22001639;24374639;2445736;2670666;2684666;6337128;6759124;7047296;8614637;8641269;8840504", "class_list": "", "function": "Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC). Can also catalyze the first methylation reaction of PE to PMME in the absence of PE methyltransferase CHO2., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWP3", "ec_number_list": "2.1.1.17;2.1.1.71", "go_molecular_function": "GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity;GO:0004608 phosphatidylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006656 phosphatidylcholine biosynthetic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P05375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05453-1", "uniprot_id": "ERF3_YEAST", "mass": 76551.0, "length": 685, "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit", "gene_name": "SUP35", "organism": "Yeast", "refseq_name": "translation termination factor GTPase eRF3", "refseq_ac": "NP_010457", "gene_names_uniprotkb": "SUP35; GST1; PNM2; SAL3; SUF12; SUP2; YD9395.05", "gene_names_refseq": "GST1; PNM2; SAL3; SUF12; SUP2; SUP35; SUP36", "protein_names_uniprotkb": "Eukaryotic peptide chain release factor GTP-binding subunit; 3.6.5.-; ERF-3; ERF2; ERF3; G1 to S phase transition protein 1; Omnipotent suppressor protein 2; PSI no more protein 2; Polypeptide release factor 3; Translation release factor 3", "protein_names_refseq": "translation termination factor GTPase eRF3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR172W); (R-SCE-72764); (R-SCE-975956); (R-SCE-975957)", "pathway_count": 4, "publication_count": 38, "publication_id_list": "11511345;11971964;12923185;14562106;15029195;15029196;15337765;15525991;15944695;16809762;17170131;17330950;17563356;18267004;18407956;19795423;19823750;19917766;21126336;22814378;23749301;24374639;2841115;3047009;30516470;32597660;3280807;33229814;33481703;33491328;34413231;34965436;3556215;7556078;8670813;8978027;9169867;9335589", "class_list": "", "function": "GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:34413231, PubMed:7556078). SUP35/eRF3 mediates SUP45/eRF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:34413231, PubMed:7556078). GTP hydrolysis by SUP35/eRF3 induces a conformational change that leads to its dissociation, permitting SUP45/eRF1 to accommodate fully in the A-site (PubMed:34413231, PubMed:7556078). Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs (PubMed:12923185, PubMed:15337765). Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening (PubMed:12923185, PubMed:15337765)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VSF4;P05420", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.1.3.16;5.6.2.3;5.6.2.5;3.6.5.5;2.1.1.297;3.6.4.13", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0018444 translation release factor complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006415 translational termination;GO:0006412 translation;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P05453-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05626-1", "uniprot_id": "ATPF_YEAST", "mass": 26925.0, "length": 244, "protein_name": "ATP synthase subunit 4, mitochondrial", "gene_name": "ATP4", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit 4", "refseq_ac": "NP_015247", "gene_names_uniprotkb": "ATP4; LPF7C", "gene_names_refseq": "ATP4; LPF7", "protein_names_uniprotkb": "ATP synthase subunit 4, mitochondrial", "protein_names_refseq": "F1F0 ATP synthase subunit 4", "tax_id": 559292, "disease": "clear cell renal cell carcinoma (Disease Ontology:DOID:4467); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YPL078C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;17322287;17761666;19779198;24374639;2553130;2883007;2892678;33491328;9169875", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3T8;E9P905;Q02830", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P05626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05737-1", "uniprot_id": "RL7A_YEAST", "mass": 27638.0, "length": 244, "protein_name": "Large ribosomal subunit protein uL30A", "gene_name": "RPL7A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL30 RPL7A", "refseq_ac": "NP_011439", "gene_names_uniprotkb": "RPL7A; RPL6A; RPL8A; YL8A", "gene_names_refseq": "RPL7A", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30A; 60S ribosomal protein L7-A; L6; RP11; YL8", "protein_names_refseq": "60S ribosomal protein uL30 RPL7A", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL076C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 34, "publication_id_list": "10601260;11701127;11875433;14562095;14562106;14976550;1544921;1549461;15665377;17287358;17330950;17563356;18407956;18782943;19684113;19779198;19795423;19823750;20702584;21109664;21126336;21177495;22096102;22814378;23749301;24374639;24524803;32597660;33481703;33491328;34965436;9169869;9290212;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU68;P87029", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0002181 cytoplasmic translation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P05737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05739-1", "uniprot_id": "RL6B_YEAST", "mass": 19986.0, "length": 176, "protein_name": "Large ribosomal subunit protein eL6B", "gene_name": "RPL6B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL6 RPL6B", "refseq_ac": "NP_013553", "gene_names_uniprotkb": "RPL6B; L9324.4; RPL16B; RPL17B; YL16B", "gene_names_refseq": "RPL6B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL6B; 60S ribosomal protein L6-B; L17; RP18; YL16", "protein_names_refseq": "60S ribosomal protein eL6 RPL6B", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR448W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "1390890;14562095;14562106;15665377;18407956;18782943;22096102;22106047;24374639;24524803;33481703;33491328;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ82", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P05739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05740-1", "uniprot_id": "RL17A_YEAST", "mass": 20549.0, "length": 184, "protein_name": "Large ribosomal subunit protein uL22A", "gene_name": "RPL17A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL22 RPL17A", "refseq_ac": "NP_012741", "gene_names_uniprotkb": "RPL17A; RPL17; RPL20A", "gene_names_refseq": "RPL17A; RPL17", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22A; 60S ribosomal protein L17-A; L20A; YL17", "protein_names_refseq": "60S ribosomal protein uL22 RPL17A", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL180W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 20, "publication_id_list": "10601260;11701127;14562095;14976550;15665377;17287358;18782943;19780626;20702584;21109664;21126336;22096102;22106047;24374639;24524803;32597660;33481703;8154185;8196765;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX21", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P05740-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05744-1", "uniprot_id": "RL33A_YEAST", "mass": 12154.0, "length": 107, "protein_name": "Large ribosomal subunit protein eL33A", "gene_name": "RPL33A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL33 RPL33A", "refseq_ac": "NP_015182", "gene_names_uniprotkb": "RPL33A; LPI4W; P2625; RPL37A", "gene_names_refseq": "GCD17; RPL33A; RPL37A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL33A; 60S ribosomal protein L33-A; L37; RP47; YL37", "protein_names_refseq": "60S ribosomal protein eL33 RPL33A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 5 (Disease Ontology:DOID:0111883); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (sce:YPL143W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "10601260;1840541;18782943;21109664;22096102;22106047;24374639;24524803;32597660;33481703;33491328;8948103;9169875;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. 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The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W018", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000470 maturation of LSU-rRNA;GO:0180023 cytosolic large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P05745-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05748-1", "uniprot_id": "RL15A_YEAST", "mass": 24422.0, "length": 204, "protein_name": "Large ribosomal subunit protein eL15A", "gene_name": "RPL15A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL15 RPL15A", "refseq_ac": "NP_013129", "gene_names_uniprotkb": "RPL15A; RPL10A; RPL13A; YL10A", "gene_names_refseq": "RPL10A; RPL15A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL15A; 60S ribosomal protein L15-A; L13; RP15R; YL10; YP18", "protein_names_refseq": "60S ribosomal protein eL15 RPL15A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 12 (Disease Ontology:DOID:0111882)", "pathway": " (sce:YLR029C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 17, "publication_id_list": "11701127;14976550;1544921;17287358;19779198;19795423;19823750;21109664;22096102;22814378;23749301;24374639;24524803;33481703;6814480;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY31", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000470 maturation of LSU-rRNA;GO:0180023 cytosolic large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P05748-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05750-1", "uniprot_id": "RS3_YEAST", "mass": 26503.0, "length": 240, "protein_name": "Small ribosomal subunit protein uS3", "gene_name": "RPS3", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS3 RPS3", "refseq_ac": "NP_014221", "gene_names_uniprotkb": "RPS3; N1653; SUF14", "gene_names_refseq": "RPS3; SUF14", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3; 40S ribosomal protein S3; RP13; YS3", "protein_names_refseq": "40S ribosomal protein uS3 RPS3", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (sce:YNL178W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 43, "publication_id_list": "10601260;11701127;12872131;14562106;14976550;1544921;15665377;17287358;17330950;17563356;18407956;18782943;19684113;19779198;19823750;20702584;20980660;21109664;21126336;22096102;22106047;22218487;22650761;22814378;23749301;24021814;24200810;24374639;24524803;28757607;28943311;30465652;30516470;30718516;30893611;31819057;32597660;33481703;33491328;33502312;8670293;9169873;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W107", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0070651 nonfunctional rRNA decay;GO:0000054 ribosomal subunit export from nucleus;GO:1990145 maintenance of translational fidelity;GO:0002181 cytoplasmic translation;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P05750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05755-1", "uniprot_id": "RS9B_YEAST", "mass": 22299.0, "length": 195, "protein_name": "Small ribosomal subunit protein uS4B", "gene_name": "RPS9B", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS4 RPS9B", "refseq_ac": "NP_009748", "gene_names_uniprotkb": "RPS9B; RPS13B; SUP46; YBR1317", "gene_names_refseq": "RPS13A; RPS9B; SUP46", "protein_names_uniprotkb": "Small ribosomal subunit protein uS4B; 40S ribosomal protein S9-B; RP21; S13; YP28; YS11", "protein_names_refseq": "40S ribosomal protein uS4 RPS9B", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR189W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 28, "publication_id_list": "1427034;14562095;14562106;15590835;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22096102;22106047;23749301;24374639;24524803;30516470;32597660;33481703;33491328;6814480;7813418;7871891;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS4 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQI4", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030686 90S preribosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0045903 positive regulation of translational fidelity;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P05755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05756-1", "uniprot_id": "RS13_YEAST", "mass": 17029.0, "length": 151, "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "RPS13", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS15 RPS13", "refseq_ac": "NP_010349", "gene_names_uniprotkb": "RPS13; D4252; RPS13C; YD9609.18", "gene_names_refseq": "RPS13B; RPS13C; RPS13", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15; 40S ribosomal protein S13; S27a; YS15", "protein_names_refseq": "40S ribosomal protein uS15 RPS13", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (sce:YDR064W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 20, "publication_id_list": "10601260;11701127;14976550;15665377;18407956;19779198;21109664;21126336;22096102;22106047;23749301;24374639;24524803;32597660;33481703;33491328;6814480;8789263;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS50", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030686 90S preribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P05756-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05759-1", "uniprot_id": "RS31_YEAST", "mass": 17216.0, "length": 152, "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS31", "organism": "Yeast", "refseq_name": "ubiquitin-40S ribosomal protein eS31 RPS31 fusion protein", "refseq_ac": "NP_013268", "gene_names_uniprotkb": "RPS31; L9470.14; RPS37; UBI3", "gene_names_refseq": "RPS31; RPS37; UBI3", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein; 40S ribosomal protein S31; CEP76; S37; YS24", "protein_names_refseq": "ubiquitin-40S ribosomal protein eS31 RPS31 fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR167W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11875433;17287358;18407956;18782943;19779198;19795423;19823750;21177495;22096102;23749301;24374639;24524803;2538753;29130884;3038523;32597660;33481703;33491328;7615550;7862120;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYH3;P04838;P14800;P61864;Q6LA96", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:1990145 maintenance of translational fidelity;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P05759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05986-1", "uniprot_id": "KAPC_YEAST", "mass": 45977.0, "length": 398, "protein_name": "cAMP-dependent protein kinase type 3", "gene_name": "TPK3", "organism": "Yeast", "refseq_name": "cAMP-dependent protein kinase catalytic subunit TPK3", "refseq_ac": "NP_012755", "gene_names_uniprotkb": "TPK3; PKA3; YKL630", "gene_names_refseq": "TPK3", "protein_names_uniprotkb": "cAMP-dependent protein kinase type 3; 2.7.11.11; PKA 3", "protein_names_refseq": "cAMP-dependent protein kinase catalytic subunit TPK3", "tax_id": 559292, "disease": "adrenal cortical adenoma (Disease Ontology:DOID:0050891); primary pigmented nodular adrenocortical disease 4 (Disease Ontology:DOID:0070549); platelet-type bleeding disorder 19 (Disease Ontology:DOID:0111048); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); fibrolamellar carcinoma (Disease Ontology:DOID:5015); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (sce:YKL166C); (R-SCE-163615); (R-SCE-164378); (R-SCE-180024); (R-SCE-432040); (R-SCE-442720); (R-SCE-5610787); (R-SCE-9634597); (R-SCE-983231); (R-SCE-9856530)", "pathway_count": 10, "publication_count": 21, "publication_id_list": "14562106;1544898;15665377;17287358;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;23749301;24374639;3036373;32597660;33481703;33491328;8091858;8196765", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX33", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;1.6.2.4;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007265 Ras protein signal transduction;GO:0007005 mitochondrion organization;GO:0070314 G1 to G0 transition;GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P05986-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06100-1", "uniprot_id": "NOT2_YEAST", "mass": 22363.0, "length": 191, "protein_name": "General negative regulator of transcription subunit 2", "gene_name": "CDC36", "organism": "Yeast", "refseq_name": "CCR4-NOT core subunit CDC36", "refseq_ac": "NP_010116", "gene_names_uniprotkb": "CDC36; DNA19; NOT2", "gene_names_refseq": "CDC36; DNA19; NOT2", "protein_names_uniprotkb": "General negative regulator of transcription subunit 2; cell division cycle protein 36", "protein_names_refseq": "CCR4-NOT core subunit CDC36", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL165W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10490603;11733989;11889048;12215412;14562106;17322287;24374639;3018676;3909103;7926748;9169867;9463387", "class_list": "", "function": "Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRI6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0016567 protein ubiquitination;GO:0006368 transcription elongation by RNA polymerase II;GO:0051726 regulation of cell cycle;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P06100-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06101-1", "uniprot_id": "CDC37_YEAST", "mass": 58385.0, "length": 506, "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "CDC37", "organism": "Yeast", "refseq_name": "Hsp90 co-chaperone CDC37", "refseq_ac": "NP_010452", "gene_names_uniprotkb": "CDC37; SMO1; YD9489.03", "gene_names_refseq": "CDC37; SMO1", "protein_names_uniprotkb": "Hsp90 co-chaperone Cdc37; Cell division control protein 37; Hsp90 chaperone protein kinase-targeting subunit", "protein_names_refseq": "Hsp90 co-chaperone CDC37", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR168W); (R-SCE-114608)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "10629030;10664467;12435747;14562095;14562106;15659792;15665377;17220467;17242065;17287358;17330950;17563356;18407956;18922470;19399909;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;24452458;24909858;3018676;30516470;32597660;33481703;33491328;7753858;9169867;9779198", "class_list": "", "function": "Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Involved in both the HOG and the PKC MAP kinase signaling cascade necessary for adaptation to stress conditions due to high osmolarity or cell wall perturbation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSE8;Q04132", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0051301 cell division;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0071474 cellular hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P06101-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06102-1", "uniprot_id": "NOT3_YEAST", "mass": 94403.0, "length": 836, "protein_name": "General negative regulator of transcription subunit 3", "gene_name": "NOT3", "organism": "Yeast", "refseq_name": "CCR4-NOT core subunit NOT3", "refseq_ac": "NP_012226", "gene_names_uniprotkb": "NOT3", "gene_names_refseq": "NOT3", "protein_names_uniprotkb": "General negative regulator of transcription subunit 3", "protein_names_refseq": "CCR4-NOT core subunit NOT3", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL038C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11733989;11875433;14562106;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;23749301;24374639;3018676;30516470;32597660;33229814;33481703;33491328;7926748;9169870;9463387", "class_list": "", "function": "Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 51, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VVP4;Q6B233", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P06102-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06103-1", "uniprot_id": "EIF3B_YEAST", "mass": 88130.0, "length": 763, "protein_name": "Eukaryotic translation initiation factor 3 subunit B", "gene_name": "PRT1", "organism": "Yeast", "refseq_name": "translation initiation factor eIF3 core subunit b", "refseq_ac": "NP_015006", "gene_names_uniprotkb": "PRT1; CDC63", "gene_names_refseq": "CDC63; DNA26; PRT1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit B; Cell cycle regulation and translation initiation protein; Eukaryotic translation initiation factor 3 90 kDa subunit; Translation initiation factor eIF3 p90 subunit; eIF3 p90; eIF3b", "protein_names_refseq": "translation initiation factor eIF3 core subunit b", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR361C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "11387228;11457827;14562095;14562106;16581774;17563356;18407956;18599441;19779198;19795423;19823750;21280672;24374639;3029094;32027465;32597660;33481703;33491328;9169874;9671501", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W356", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P06103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06104-1", "uniprot_id": "UBC2_YEAST", "mass": 19706.0, "length": 172, "protein_name": "Ubiquitin-conjugating enzyme E2 2", "gene_name": "RAD6", "organism": "Yeast", "refseq_name": "E2 ubiquitin-conjugating protein RAD6", "refseq_ac": "NP_011457", "gene_names_uniprotkb": "RAD6; UBC2", "gene_names_refseq": "PSO8; RAD6; UBC2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 2; 2.3.2.23; E2 ubiquitin-conjugating enzyme 2; Radiation sensitivity protein 6; Ubiquitin carrier protein UBC2; Ubiquitin-protein ligase UBC2", "protein_names_refseq": "E2 ubiquitin-conjugating protein RAD6", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); syndromic X-linked intellectual disability Nascimento type (Disease Ontology:DOID:0060820); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YGL058W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "10581257;10880451;12077605;12226657;14562095;14562106;14752010;15388802;15632065;16247017;16307922;1651502;18407956;2065660;2157209;2179869;24374639;3306404;33491328;34789879;3881753;7038392;7926769;8436296;9169869;9234674;9287349;9343433;9497353", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (PubMed:10880451, PubMed:12226657, PubMed:1651502, PubMed:2157209, PubMed:3306404, PubMed:34789879, PubMed:7038392, PubMed:7926769, PubMed:8436296, PubMed:9343433). In association with the E3 enzyme BRE1 and LGE1, it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1 (PubMed:12077605, PubMed:14752010, PubMed:16307922). H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (PubMed:12077605, PubMed:14752010, PubMed:15632065, PubMed:16307922). Together with E3 ligase RAD18, monoubiquitinates POL30/PCNA on 'Lys-164', to promote two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypasses replication-blocking lesions without removing them; PCNA monoubiquitination promotes the translesion synthesis (TLS) pathway and leads to the recruitment of translesion polymerases for lesion bypass, whereas further polyubiquitination by MMS2-UBC13-RAD5, promotes template-switching (TS) to the newly synthesized sister chromatid for synthesis past the lesion (PubMed:15388802, PubMed:15632065, PubMed:16247017, PubMed:7926769, PubMed:9287349). In association with the E3 enzyme UBR1, is involved in N-end rule-dependent protein degradation (PubMed:1651502, PubMed:2065660, PubMed:34789879, PubMed:7926769, PubMed:8436296). Also involved in sporulation (PubMed:3881753)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU83", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0070628 proteasome binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0097505 Rad6-Rad18 complex;GO:0033503 HULC complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P06104-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06105-1", "uniprot_id": "SC160_YEAST", "mass": 134810.0, "length": 1222, "protein_name": "Protein SCP160", "gene_name": "SCP160", "organism": "Yeast", "refseq_name": "Scp160p", "refseq_ac": "NP_012455", "gene_names_uniprotkb": "SCP160; HX; J1017", "gene_names_refseq": "SCP160", "protein_names_uniprotkb": "Protein SCP160; Protein HX", "protein_names_refseq": "Scp160p", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (sce:YJL080C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "15665377;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30377154;32597660;33229814;33481703;33491328;3537966;7483841;8533468;8641269", "class_list": "", "function": "Involved in the control of mitotic chromosome transmission. Required during cell division for faithful partitioning of the ER-nuclear envelope membranes which, in S.cerevisiae, enclose the duplicated chromosomes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 40, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VWA3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0007059 chromosome segregation;GO:0045141 meiotic telomere clustering;GO:0043577 chemotropism;GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P06105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06106-1", "uniprot_id": "CYSD_YEAST", "mass": 48672.0, "length": 444, "protein_name": "Homocysteine/cysteine synthase", "gene_name": "MET17", "organism": "Yeast", "refseq_name": "bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17", "refseq_ac": "NP_013406", "gene_names_uniprotkb": "MET17; L8003.1; MET15; MET25", "gene_names_refseq": "MET15; MET17; MET25", "protein_names_uniprotkb": "Homocysteine/cysteine synthase; 2.5.1.47; 2.5.1.49; O-acetylserine/O-acetylhomoserine sulfhydrylase; OAS-OAH SHLase; OAS-OAH sulfhydrylase", "protein_names_refseq": "bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR303W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11914276;12586406;1732168;17322287;17330950;17563356;1781681;18407956;22106047;24374639;3022238;3299001;33481703;33491328;36379252;36455053;4609980;4947307;7765825;795806;795807;8511969;8935650;9169871", "class_list": "", "function": "Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (PubMed:36379252, PubMed:36455053, PubMed:4609980, PubMed:7765825, PubMed:795806). Required to efficiently reduce toxic levels of hydrogen sulfide generated when the sulfate assimilation pathway (SAP) is active (PubMed:36379252, PubMed:36455053). Also catalyzes the conversion of O-acetylserine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway (PubMed:36455053, PubMed:4609980, PubMed:7765825, PubMed:795806). However, it seems that in S.cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS (PubMed:1732168). It therefore has no metabolic role in cysteine biosynthesis and may only have a regulatory role controlling OAS levels (PubMed:12586406)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYU6", "ec_number_list": "2.5.1.47;2.5.1.49", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004124 cysteine synthase activity;GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity;GO:0051009 O-acetylhomoserine sulfhydrylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006555 methionine metabolic process;GO:0019346 transsulfuration;GO:0019344 cysteine biosynthetic process;GO:0000103 sulfate assimilation;GO:0071269 L-homocysteine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P06106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06115-1", "uniprot_id": "CATT_YEAST", "mass": 64583.0, "length": 562, "protein_name": "Catalase T", "gene_name": "CTT1", "organism": "Yeast", "refseq_name": "catalase T", "refseq_ac": "NP_011602", "gene_names_uniprotkb": "CTT1", "gene_names_refseq": "CTT1; SPS101", "protein_names_uniprotkb": "Catalase T; 1.11.1.6", "protein_names_refseq": "catalase T", "tax_id": 559292, "disease": "pterygium (Disease Ontology:DOID:0002116); chronic venous insufficiency (Disease Ontology:DOID:0050853); colitis (Disease Ontology:DOID:0060180); alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); Graves ophthalmopathy (Disease Ontology:DOID:0081120); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); retinitis pigmentosa (Disease Ontology:DOID:10584); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); essential hypertension (Disease Ontology:DOID:10825); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); optic neuritis (Disease Ontology:DOID:1210); tympanosclerosis (Disease Ontology:DOID:1214); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); Behcet's disease (Disease Ontology:DOID:13241); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); keratosis (Disease Ontology:DOID:161); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); acatalasia (Disease Ontology:DOID:2582); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast adenocarcinoma (Disease Ontology:DOID:3458); toxic encephalopathy (Disease Ontology:DOID:3602); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ureteral obstruction (Disease Ontology:DOID:5199); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); congestive heart failure (Disease Ontology:DOID:6000); fibromyalgia (Disease Ontology:DOID:631); acne (Disease Ontology:DOID:6543); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); scabies (Disease Ontology:DOID:8295); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); seborrheic dermatitis (Disease Ontology:DOID:8741); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); pemphigus (Disease Ontology:DOID:9182); lichen planus (Disease Ontology:DOID:9201); phenylketonuria (Disease Ontology:DOID:9281); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); stomatitis (Disease Ontology:DOID:9637); senile cataract (Disease Ontology:DOID:9669); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (sce:YGR088W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;15905473;18407956;19779198;19795423;19823750;2423850;24374639;33491328;3536508;9038161;9169869", "class_list": "", "function": "Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 77, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUM0", "ec_number_list": "1.11.1.6", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004096 catalase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0042542 response to hydrogen peroxide;GO:0000302 response to reactive oxygen species;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P06115-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06168-1", "uniprot_id": "ILV5_YEAST", "mass": 44368.0, "length": 395, "protein_name": "Ketol-acid reductoisomerase, mitochondrial", "gene_name": "ILV5", "organism": "Yeast", "refseq_name": "ketol-acid reductoisomerase", "refseq_ac": "NP_013459", "gene_names_uniprotkb": "ILV5; L9638.7", "gene_names_refseq": "ILV5", "protein_names_uniprotkb": "Ketol-acid reductoisomerase, mitochondrial; 1.1.1.86; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; Isoleucine-plus-valine requiring protein 5", "protein_names_refseq": "ketol-acid reductoisomerase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR355C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;18407956;19779198;20702584;23749301;24374639;3027658;32597660;33481703;33491328;7895733;8962070;9169871", "class_list": "", "function": "Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes the second common step in the parallel biosynthesis of isoleucine and valine. Converts alpha-aceto-alpha-hydroxybutyrate (AHB) to alpha,beta-dihydroxy-beta-methylvalerate (DHMV) and alpha-acetolactate (AL) to alpha,beta-dihydroxy-isovalerate (DHV) in isoleucine and valine biosynthesis, respectively., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYZ3", "ec_number_list": "1.1.1.86", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003690 double-stranded DNA binding;GO:0004455 ketol-acid reductoisomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0009082 branched-chain amino acid biosynthetic process;GO:0009099 L-valine biosynthetic process;GO:0009097 isoleucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P06168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06169-1", "uniprot_id": "PDC1_YEAST", "mass": 61495.0, "length": 563, "protein_name": "Pyruvate decarboxylase isozyme 1", "gene_name": "PDC1", "organism": "Yeast", "refseq_name": "indolepyruvate decarboxylase 1", "refseq_ac": "NP_013145", "gene_names_uniprotkb": "PDC1; L2104", "gene_names_refseq": "PDC1", "protein_names_uniprotkb": "Pyruvate decarboxylase isozyme 1; 2ODC; 4.1.1.-; 4.1.1.43; 4.1.1.72; 4.1.1.74; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase", "protein_names_refseq": "indolepyruvate decarboxylase 1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR044C)", "pathway_count": 1, "publication_count": 44, "publication_id_list": "10231381;10234824;10545125;10651824;10753893;11141278;11283598;12499363;12902239;14562095;14562106;17287358;17330950;18407956;19684113;19779198;19795423;19823750;21126336;2185016;22106047;22904058;23642236;23749301;24374639;26046779;32597660;33481703;33491328;3537965;4687392;6383467;7050079;7737086;7895733;8512926;8604141;8866484;9169871;9298649;9341119;9655908;9655924;9748245", "class_list": "", "function": "Major of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-ketoacids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from threonine (2-oxobutanoate), norvaline (2-oxopentanoate), valine (3-methyl-2-oxobutanoate, also alpha-keto-isovalerate), isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), phenylalanine (phenylpyruvate), and tryptophan (3-(indol-3-yl)pyruvate), whereas transaminated leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY46;O00042;Q07991;Q12682;Q12686;Q12687", "ec_number_list": "4.1.1.-;4.1.1.43;4.1.1.72;4.1.1.74;4.1.1.80", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004737 pyruvate decarboxylase activity;GO:0047433 branched-chain-2-oxoacid decarboxylase activity;GO:0047434 indolepyruvate decarboxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway;GO:0019655 glycolytic fermentation to ethanol", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P06169-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06197-1", "uniprot_id": "PIS_YEAST", "mass": 24824.0, "length": 220, "protein_name": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase", "gene_name": "PIS1", "organism": "Yeast", "refseq_name": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase", "refseq_ac": "NP_015438", "gene_names_uniprotkb": "PIS1; P8283.5", "gene_names_refseq": "PIS1", "protein_names_uniprotkb": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase; 2.7.8.11; PI synthase; PIS; Phosphatidylinositol synthase; PtdIns synthase", "protein_names_refseq": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase", "tax_id": 559292, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (sce:YPR113W); (R-SCE-1483226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;16823961;16847258;24374639;25687304;3005242;3005284;3031032;6274497;8543066;9169875", "class_list": "", "function": "Catalyzes the synthesis of phosphatidylinositol (PtdIns)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4B2", "ec_number_list": "2.7.8.11", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P06197-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06208-1", "uniprot_id": "LEU1_YEAST", "mass": 68409.0, "length": 619, "protein_name": "2-isopropylmalate synthase", "gene_name": "LEU4", "organism": "Yeast", "refseq_name": "2-isopropylmalate synthase LEU4", "refseq_ac": "NP_014295", "gene_names_uniprotkb": "LEU4; N2173", "gene_names_refseq": "LEU4", "protein_names_uniprotkb": "2-isopropylmalate synthase; 2.3.3.13; Alpha-IPM synthase; Alpha-isopropylmalate synthase", "protein_names_refseq": "2-isopropylmalate synthase LEU4", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL104C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10790691;14562106;19795423;19823750;22814378;2420798;24374639;32597660;3275644;33481703;33491328;8446029;8701612;9169873", "class_list": "", "function": "Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W175", "ec_number_list": "2.3.3.13", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003852 2-isopropylmalate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009098 L-leucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P06208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06242-1", "uniprot_id": "KIN28_YEAST", "mass": 35247.0, "length": 306, "protein_name": "Serine/threonine-protein kinase KIN28", "gene_name": "KIN28", "organism": "Yeast", "refseq_name": "TFIIH complex serine/threonine-protein kinase subunit KIN28", "refseq_ac": "NP_010175", "gene_names_uniprotkb": "KIN28; D2330", "gene_names_refseq": "KIN28", "protein_names_uniprotkb": "Serine/threonine-protein kinase KIN28; 2.7.11.23", "protein_names_refseq": "TFIIH complex serine/threonine-protein kinase subunit KIN28", "tax_id": 559292, "disease": "primary congenital glaucoma (Disease Ontology:DOID:0050593); brachydactyly type A2 (Disease Ontology:DOID:0110965); Alzheimer's disease (Disease Ontology:DOID:10652); essential hypertension (Disease Ontology:DOID:10825); breast cancer (Disease Ontology:DOID:1612); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YDL108W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 15, "publication_count": 27, "publication_id_list": "10373527;10594013;10958787;11805111;11839796;12743037;14562095;14562106;15665377;17330950;17563356;17956857;18407956;20489023;22218487;23749301;24374639;32597660;33481703;33491328;33827808;3536482;8230216;8896274;9169867;9235928;9774652", "class_list": "", "function": "Catalytic component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro. Essential for cell proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRP2", "ec_number_list": "2.7.7.6;2.7.11.23;5.6.2.3;3.1.-.-;2.7.7.7;3.1.11.-;2.7.11.22;2.3.2.27;2.1.1.56;3.1.3.16;3.6.4.-;2.3.1.48;3.4.19.12;5.2.1.8;5.6.2.4;2.7.7.50", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005675 transcription factor TFIIH holo complex;GO:0070985 transcription factor TFIIK complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0010508 positive regulation of autophagy;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P06242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06243-1", "uniprot_id": "CDC7_YEAST", "mass": 58320.0, "length": 507, "protein_name": "Cell division control protein 7", "gene_name": "CDC7", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase CDC7", "refseq_ac": "NP_010267", "gene_names_uniprotkb": "CDC7; D2855; OAF2", "gene_names_refseq": "CDC7; LSD6; SAS1", "protein_names_uniprotkb": "Cell division control protein 7; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase CDC7", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL017W); (R-SCE-176187); (R-SCE-68962)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "14562106;18407956;1865880;20489023;23749301;24374639;2668893;2850010;33481703;33491328;3537706;8382976;9169867", "class_list": "", "function": "Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRX3", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.7.-;2.7.7.7;2.7.12.1;2.7.11.24;3.1.11.-;2.7.11.17;2.7.11.23;2.7.11.25;3.6.4.12;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin", "go_biological_process": "GO:1902977 mitotic DNA replication preinitiation complex assembly;GO:1905342 positive regulation of protein localization to kinetochore;GO:0007165 signal transduction;GO:0051301 cell division;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P06243-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06244-1", "uniprot_id": "KAPA_YEAST", "mass": 46076.0, "length": 397, "protein_name": "cAMP-dependent protein kinase type 1", "gene_name": "TPK1", "organism": "Yeast", "refseq_name": "cAMP-dependent protein kinase catalytic subunit TPK1", "refseq_ac": "NP_012371", "gene_names_uniprotkb": "TPK1; J0541; PKA1; SRA3", "gene_names_refseq": "PKA1; SRA3; TPK1", "protein_names_uniprotkb": "cAMP-dependent protein kinase type 1; 2.7.11.11; CDC25-suppressing protein kinase; PK-25; PKA 1", "protein_names_refseq": "cAMP-dependent protein kinase catalytic subunit TPK1", "tax_id": 559292, "disease": "adrenal cortical adenoma (Disease Ontology:DOID:0050891); primary pigmented nodular adrenocortical disease 4 (Disease Ontology:DOID:0070549); platelet-type bleeding disorder 19 (Disease Ontology:DOID:0111048); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); fibrolamellar carcinoma (Disease Ontology:DOID:5015); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (sce:YJL164C); (R-SCE-163615); (R-SCE-164378); (R-SCE-180024); (R-SCE-432040); (R-SCE-442720); (R-SCE-5610787); (R-SCE-9634597); (R-SCE-983231); (R-SCE-9856530)", "pathway_count": 10, "publication_count": 22, "publication_id_list": "11368172;14562095;14562106;15665377;15905473;17563356;18407956;19779198;19795423;19823750;21531713;22814378;23749301;24374639;24947305;2823100;3036373;32597660;33481703;33491328;3546292;8641269", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW23;P11595;Q2VQW1", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;1.6.2.4;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051301 cell division;GO:0016241 regulation of macroautophagy;GO:0007265 Ras protein signal transduction;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P06244-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06245-1", "uniprot_id": "KAPB_YEAST", "mass": 44220.0, "length": 380, "protein_name": "cAMP-dependent protein kinase type 2", "gene_name": "TPK2", "organism": "Yeast", "refseq_name": "cAMP-dependent protein kinase catalytic subunit TPK2", "refseq_ac": "NP_015121", "gene_names_uniprotkb": "TPK2; PKA2; YKR1", "gene_names_refseq": "PKA2; PKA3; TPK2; YKR1", "protein_names_uniprotkb": "cAMP-dependent protein kinase type 2; 2.7.11.11; PKA 2", "protein_names_refseq": "cAMP-dependent protein kinase catalytic subunit TPK2", "tax_id": 559292, "disease": "adrenal cortical adenoma (Disease Ontology:DOID:0050891); primary pigmented nodular adrenocortical disease 4 (Disease Ontology:DOID:0070549); platelet-type bleeding disorder 19 (Disease Ontology:DOID:0111048); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); fibrolamellar carcinoma (Disease Ontology:DOID:5015); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (sce:YPL203W); (R-SCE-163615); (R-SCE-164378); (R-SCE-180024); (R-SCE-432040); (R-SCE-442720); (R-SCE-5610787); (R-SCE-9634597); (R-SCE-983231); (R-SCE-9837999); (R-SCE-9856530)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "14562106;15665377;18407956;20489023;22814378;23749301;24374639;3036373;3308514;33481703;33491328;9169875", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3G6", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;1.6.2.4;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0000785 chromatin;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0071333 cellular response to glucose stimulus;GO:0007265 Ras protein signal transduction;GO:0070314 G1 to G0 transition;GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P06245-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06367-1", "uniprot_id": "RS14A_YEAST", "mass": 14537.0, "length": 137, "protein_name": "Small ribosomal subunit protein uS11A", "gene_name": "RPS14A", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS11 RPS14A", "refseq_ac": "NP_009960", "gene_names_uniprotkb": "RPS14A; CRY1; RPL59; YCR31C", "gene_names_refseq": "CRY1; RPL59; RPS14A", "protein_names_uniprotkb": "Small ribosomal subunit protein uS11A; 40S ribosomal protein S14-A; RP59A", "protein_names_refseq": "40S ribosomal protein uS11 RPS14A", "tax_id": 559292, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); chromosome 5q deletion syndrome (Disease Ontology:DOID:0090016); anemia (Disease Ontology:DOID:2355)", "pathway": " (sce:YCR031C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10601260;11701127;14562106;14976550;1544921;15590835;15665377;1574125;17287358;18407956;19684113;19779198;21109664;21126336;22096102;22218487;22814378;23749301;24374639;24524803;3037334;31036831;33491328;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS11 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR41;Q96VG9", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030686 90S preribosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P06367-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06634-1", "uniprot_id": "DED1_YEAST", "mass": 65553.0, "length": 604, "protein_name": "ATP-dependent RNA helicase DED1", "gene_name": "DED1", "organism": "Yeast", "refseq_name": "DEAD-box ATP-dependent RNA helicase DED1", "refseq_ac": "NP_014847", "gene_names_uniprotkb": "DED1; SPP81", "gene_names_refseq": "DED1; SPP81", "protein_names_uniprotkb": "ATP-dependent RNA helicase DED1; 3.6.4.13; DEAD box protein 1; Defines essential domain protein 1", "protein_names_refseq": "DEAD-box ATP-dependent RNA helicase DED1", "tax_id": 559292, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); childhood medulloblastoma (Disease Ontology:DOID:3869); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YOR204W); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 39, "publication_id_list": "10364207;11069307;14671320;14763975;15064363;15201868;16216083;17287358;17330950;17563356;18332124;18407956;19684113;19779198;1996139;20702584;21126336;21177495;22106047;22218487;22814378;23749301;23865587;24374639;24909858;26046779;3001645;30377154;30516470;31141444;32597660;33481703;33491328;33856219;34965436;7835345;9045610;9144215;9169874", "class_list": "", "function": "ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes. Has weak ATP-dependent affinity for dsRNA, but strong ATP-dependent affinity for ssRNA. Acts as a virus host factor involved in the replication of the MBV and the L-A viruses by promoting the negative-strand RNA synthesis. May be involved in recognition of the preinitiation complex and DNA binding of the RNA polymerase III and play a role in mRNA splicing., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R0", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;5.6.2.3;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;3.6.-.-;5.6.2.4;5.2.1.8;1.11.1.6;3.5.4.6;3.6.4.-;2.7.1.11;5.6.1.4;2.7.1.2;1.1.1.42;3.6.4.12;3.4.25.1;3.6.4.6;5.6.2.5;3.6.5.-;2.7.11.24;3.6.1.-;2.3.2.27;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;3.1.-.-;3.4.24.-;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0002151 G-quadruplex RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006413 translational initiation;GO:0000390 spliceosomal complex disassembly;GO:1901195 positive regulation of formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P06634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06700-1", "uniprot_id": "SIR2_YEAST", "mass": 63262.0, "length": 562, "protein_name": "NAD-dependent histone deacetylase SIR2", "gene_name": "SIR2", "organism": "Yeast", "refseq_name": "NAD-dependent histone deacetylase SIR2", "refseq_ac": "NP_010242", "gene_names_uniprotkb": "SIR2; D2714; MAR1", "gene_names_refseq": "MAR1; SIR2", "protein_names_uniprotkb": "NAD-dependent histone deacetylase SIR2; 2.3.1.286; Regulatory protein SIR2; Silent information regulator 2", "protein_names_refseq": "NAD-dependent histone deacetylase SIR2", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YDL042C); (R-SCE-3371453)", "pathway_count": 2, "publication_count": 37, "publication_id_list": "10219244;10219245;10619427;10662670;10693811;11348596;11722841;12399377;12399383;12923057;12939617;14562106;15274642;16328881;17330950;17563356;18086879;18407956;19220062;19779198;19795423;19823750;20489023;20702584;22362748;23307867;23749301;24374639;32597660;33481703;33491328;6098447;9046088;9122169;9169867;9214640;9278054", "class_list": "", "function": "NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on histone H3K9Ac and H3K14Ac and histone H4K16Ac in vitro, such activity is unclear in vivo and may not be essential., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRV4", "ec_number_list": "2.3.1.286;3.6.4.10", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005677 chromatin silencing complex;GO:0000792 heterochromatin;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P06700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06701-1", "uniprot_id": "SIR3_YEAST", "mass": 111360.0, "length": 978, "protein_name": "Regulatory protein SIR3", "gene_name": "SIR3", "organism": "Yeast", "refseq_name": "chromatin-silencing protein SIR3", "refseq_ac": "NP_013547", "gene_names_uniprotkb": "SIR3; CMT1; L9753.10; MAR2; STE8", "gene_names_refseq": "CMT1; MAR2; SIR3; STE8", "protein_names_uniprotkb": "Regulatory protein SIR3; Silent information regulator 3", "protein_names_refseq": "chromatin-silencing protein SIR3", "tax_id": 559292, "disease": "Meier-Gorlin syndrome 1 (Disease Ontology:DOID:0080512)", "pathway": " (sce:YLR442C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11722841;12640455;14562106;15454564;16328881;16641491;17322287;18407956;19779198;20702584;23749301;24374639;32597660;33229814;33481703;33491328;6098447;8909534;9169871", "class_list": "", "function": "The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ77;E9P924", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005677 chromatin silencing complex;GO:0000792 heterochromatin;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0006351 DNA-templated transcription;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P06701-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06704-1", "uniprot_id": "CDC31_YEAST", "mass": 18751.0, "length": 161, "protein_name": "Cell division control protein 31", "gene_name": "CDC31", "organism": "Yeast", "refseq_name": "centrin", "refseq_ac": "NP_014900", "gene_names_uniprotkb": "CDC31; DSK1", "gene_names_refseq": "CDC31; DSK1", "protein_names_uniprotkb": "Cell division control protein 31; Nuclear pore protein CDC31; Nucleoporin CDC31", "protein_names_refseq": "centrin", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR257W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10684247;11156974;11935220;12486115;12791264;14504268;17322287;18407956;19795423;19823750;20368617;20489023;21126336;22218487;24374639;28122955;33481703;33491328;3526331;7876310;8070654;8188750;9153759;9169874;9813095", "class_list": "", "function": "Functions as a component of the spindle pole body (SPB) half-bridge (PubMed:10684247, PubMed:11156974, PubMed:12486115, PubMed:14504268, PubMed:8070654). At the SPB, it is recruited by KAR1 and MPS3 to the SPB half-bridge and involved in the initial steps of SPB duplication (PubMed:11156974, PubMed:12486115, PubMed:14504268, PubMed:8070654). Also involved in connection with the protein kinase KIC1 in the maintenance of cell morphology and integrity (PubMed:9813095). May play a role in vesicle-mediated transport, in a VPS13-dependent manner (PubMed:28122955)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2V8", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0070390 transcription export complex 2;GO:0005825 half bridge of spindle pole body;GO:0044732 mitotic spindle pole body", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P06704-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06738-1", "uniprot_id": "PHSG_YEAST", "mass": 103275.0, "length": 902, "protein_name": "Glycogen phosphorylase", "gene_name": "GPH1", "organism": "Yeast", "refseq_name": "glycogen phosphorylase", "refseq_ac": "NP_015486", "gene_names_uniprotkb": "GPH1; P9584.1", "gene_names_refseq": "GPH1", "protein_names_uniprotkb": "Glycogen phosphorylase; 2.4.1.1", "protein_names_refseq": "glycogen phosphorylase", "tax_id": 559292, "disease": "cholestasis (Disease Ontology:DOID:13580); glycogen storage disease V (Disease Ontology:DOID:2746); glycogen storage disease (Disease Ontology:DOID:2747); glycogen storage disease VI (Disease Ontology:DOID:2754); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (sce:YPR160W); (R-SCE-6798695); (R-SCE-70221)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "1092346;15665377;1613787;17330950;17563356;18407956;19779198;20702584;21126336;21177495;22218487;22814378;23749301;24146988;24374639;27203179;32597660;33481703;33491328;3537803;38832010;6354094;7592925;7634071;7871892;8703213;9169875", "class_list": "", "function": "Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4G1", "ec_number_list": "2.7.1.40;3.5.3.1;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;2.7.11.13;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.27;1.11.1.25;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;4.6.1.19;5.4.2.7;2.3.2.26;3.-.-.-;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;5.3.4.1", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P06738-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06774-1", "uniprot_id": "HAP2_YEAST", "mass": 29867.0, "length": 265, "protein_name": "Transcriptional activator HAP2", "gene_name": "HAP2", "organism": "Yeast", "refseq_name": "transcription activator HAP2", "refseq_ac": "NP_011277", "gene_names_uniprotkb": "HAP2", "gene_names_refseq": "HAP2", "protein_names_uniprotkb": "Transcriptional activator HAP2", "protein_names_refseq": "transcription activator HAP2", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YGL237C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11390369;15075264;16278450;18407956;19779198;20702584;21126336;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;3547076;8223474;9169869", "class_list": "", "function": "Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP2 has primarily a structural role in the HAP complexes I and II., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV97", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0006109 regulation of carbohydrate metabolic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P06774-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06777-1", "uniprot_id": "RAD1_YEAST", "mass": 126370.0, "length": 1100, "protein_name": "DNA repair protein RAD1", "gene_name": "RAD1", "organism": "Yeast", "refseq_name": "ssDNA endodeoxyribonuclease RAD1", "refseq_ac": "NP_015303", "gene_names_uniprotkb": "RAD1", "gene_names_refseq": "LPB9; RAD12; RAD1", "protein_names_uniprotkb": "DNA repair protein RAD1", "protein_names_refseq": "ssDNA endodeoxyribonuclease RAD1", "tax_id": 559292, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); XFE progeroid syndrome (Disease Ontology:DOID:0060590); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843); xeroderma pigmentosum group F (Disease Ontology:DOID:0110848); Fanconi anemia complementation group Q (Disease Ontology:DOID:0111093); Fanconi anemia (Disease Ontology:DOID:13636); polyneuropathy due to drug (Disease Ontology:DOID:14184); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); Cockayne syndrome (Disease Ontology:DOID:2962); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YPL022W); (R-SCE-6782135)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562106;17563356;17989249;18471978;19779198;20489023;21126336;23749301;24374639;33481703;33491328;3550428;6095044;8479526;8621533;9169875", "class_list": "", "function": "Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD10 forms an endonuclease that specifically degrades single-stranded DNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Z0", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003684 damaged DNA binding;GO:0004520 DNA endonuclease activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0005634 nucleus", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006312 mitotic recombination;GO:0000710 meiotic mismatch repair;GO:0000724 double-strand break repair via homologous recombination;GO:0000715 nucleotide-excision repair, DNA damage recognition", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P06777-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06778-1", "uniprot_id": "RAD52_YEAST", "mass": 52404.0, "length": 471, "protein_name": "DNA repair and recombination protein RAD52", "gene_name": "RAD52", "organism": "Yeast", "refseq_name": "recombinase RAD52", "refseq_ac": "NP_013680", "gene_names_uniprotkb": "RAD52", "gene_names_refseq": "RAD52", "protein_names_uniprotkb": "DNA repair and recombination protein RAD52", "protein_names_refseq": "recombinase RAD52", "tax_id": 559292, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); salivary gland carcinoma (Disease Ontology:DOID:0050904); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (sce:YML032C); (R-SCE-3108214); (R-SCE-5685938)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "13679150;14562106;16707661;17322287;18407956;18471978;19779198;19795423;19823750;23749301;24374639;32083180;32597660;33481703;33491328;6098821;9169872", "class_list": "", "function": "Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZE2", "ec_number_list": "", "go_molecular_function": "GO:0000150 DNA strand exchange activity;GO:1990814 DNA/DNA annealing activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0006312 mitotic recombination;GO:0045002 double-strand break repair via single-strand annealing;GO:0000724 double-strand break repair via homologous recombination;GO:0000727 double-strand break repair via break-induced replication;GO:0000730 DNA recombinase assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P06778-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06779-1", "uniprot_id": "RAD7_YEAST", "mass": 63777.0, "length": 565, "protein_name": "DNA repair protein RAD7", "gene_name": "RAD7", "organism": "Yeast", "refseq_name": "UV-damaged DNA-binding protein RAD7", "refseq_ac": "NP_012586", "gene_names_uniprotkb": "RAD7; J1665", "gene_names_refseq": "RAD7", "protein_names_uniprotkb": "DNA repair protein RAD7", "protein_names_refseq": "UV-damaged DNA-binding protein RAD7", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR052W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10601031;14562106;15177043;17563356;18407956;19779198;19920177;21126336;2158927;23749301;24374639;3023893;30516470;32597660;33481703;33491328;7975898;8641269", "class_list": "", "function": "Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWM3", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0000113 nucleotide-excision repair factor 4 complex", "go_biological_process": "GO:0009411 response to UV;GO:0008104 intracellular protein localization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0034644 cellular response to UV;GO:0000715 nucleotide-excision repair, DNA damage recognition", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P06779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06780-1", "uniprot_id": "RHO1_YEAST", "mass": 23152.0, "length": 209, "protein_name": "GTP-binding protein RHO1", "gene_name": "RHO1", "organism": "Yeast", "refseq_name": "Rho family GTPase RHO1", "refseq_ac": "NP_015491", "gene_names_uniprotkb": "RHO1; P9325.3", "gene_names_refseq": "RHO1", "protein_names_uniprotkb": "GTP-binding protein RHO1; 3.6.5.2; Rho-type GTPase 1", "protein_names_refseq": "Rho family GTPase RHO1", "tax_id": 559292, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YPR165W); (R-SCE-198203); (R-SCE-392451); (R-SCE-416482); (R-SCE-5625740); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013106); (R-SCE-9035034); (R-SCE-9696264); (R-SCE-9696270); (R-SCE-9696273)", "pathway_count": 12, "publication_count": 36, "publication_id_list": "11283608;11447600;11574532;11591390;11839800;12207708;12419188;12660244;12810699;12928491;15514049;15596542;17322287;20062059;22218487;22814378;24374639;3029111;33481703;33491328;3543936;40021629;7579704;8195291;8602514;8602515;8621575;8641285;8754839;8754840;8846785;8947028;9038344;9169875;9242378;9535835", "class_list": "", "function": "Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1,3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7 (PubMed:40021629)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4G6", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;2.7.11.13;3.1.3.48;3.6.5.5;1.3.1.70;3.1.4.4;3.4.11.-;3.4.-.-;3.6.4.-;1.2.1.3;1.2.1.64;2.7.11.1", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008047 enzyme activator activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P06780-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06781-1", "uniprot_id": "RHO2_YEAST", "mass": 21479.0, "length": 192, "protein_name": "GTP-binding protein RHO2", "gene_name": "RHO2", "organism": "Yeast", "refseq_name": "Rho family GTPase RHO2", "refseq_ac": "NP_014309", "gene_names_uniprotkb": "RHO2; N2237", "gene_names_refseq": "RHO2", "protein_names_uniprotkb": "GTP-binding protein RHO2; 3.6.5.2", "protein_names_refseq": "Rho family GTPase RHO2", "tax_id": 559292, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YNL090W); (R-SCE-198203); (R-SCE-392451); (R-SCE-416482); (R-SCE-5625740); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013106); (R-SCE-9035034); (R-SCE-9696264); (R-SCE-9696270); (R-SCE-9696273)", "pathway_count": 12, "publication_count": 9, "publication_id_list": "11907579;14562106;16273108;16751107;24374639;3543936;8740422;8754839;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W190;Q45TZ2", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;2.7.11.13;3.1.3.48;3.6.5.5;1.3.1.70;3.1.4.4;3.4.11.-;3.4.-.-;3.6.4.-;1.2.1.3;1.2.1.64;2.7.11.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P06781-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06782-1", "uniprot_id": "SNF1_YEAST", "mass": 72045.0, "length": 633, "protein_name": "Carbon catabolite-derepressing protein kinase", "gene_name": "SNF1", "organism": "Yeast", "refseq_name": "AMP-activated serine/threonine-protein kinase catalytic subunit SNF1", "refseq_ac": "NP_010765", "gene_names_uniprotkb": "SNF1; CAT1; CCR1; D8035.20; GLC2; PAS14", "gene_names_refseq": "CAT1; CCR1; GLC2; HAF3; PAS14; SNF1", "protein_names_uniprotkb": "Carbon catabolite-derepressing protein kinase; 2.7.11.1; Sucrose nonfermentating protein 1", "protein_names_refseq": "AMP-activated serine/threonine-protein kinase catalytic subunit SNF1", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858); cholestasis (Disease Ontology:DOID:13580); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YDR477W); (R-SCE-1632852); (R-SCE-163680); (R-SCE-200425); (R-SCE-380972)", "pathway_count": 5, "publication_count": 56, "publication_id_list": "11486005;12748292;12847291;14562106;1468623;15121831;15719021;16182287;16236260;16531232;16847059;17237508;17330950;17563356;17851534;18407956;1944227;19474788;19684113;19779198;19795423;19823750;20170726;20489023;20702584;20823513;21126336;22019086;22106047;23749301;24108357;24374639;2481228;25428989;2557546;25730376;25869125;26309257;26394309;26667037;3049551;32307893;32505207;32597660;33481703;33491328;3526554;6366512;6366513;7813428;7905477;8289797;8628258;9121458;9169867;9600950", "class_list": "", "function": "Serine/threonine protein kinase essential for release from glucose repression (PubMed:1944227, PubMed:25869125, PubMed:3049551, PubMed:3526554, PubMed:6366512, PubMed:8289797, PubMed:8628258). Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (PubMed:26667037, PubMed:8289797). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (PubMed:15719021). The complex also negatively regulates the HOG1 MAPK pathway in ER stress response including unfolded protein response (UPR) (PubMed:25730376, PubMed:26394309). Under nutrient/energy depletion, the complex phosphorylates and activates PAS kinase PSK1 which in turn activates PBS1, leading to the inhibition of the TORC1 signaling pathway (PubMed:25428989). SNF1 also interacts and phosphorylates adenylate cyclase CYR1 and negatively regulates the protein kinase A signaling pathway (PubMed:26309257). Also phosphorylates and regulates the transcriptional activator CAT8 (PubMed:15121831)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTA0", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.1.137;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;6.3.4.14;6.4.1.2;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004679 AMP-activated protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031965 nuclear membrane", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0016239 positive regulation of macroautophagy;GO:0017148 negative regulation of translation;GO:0000132 establishment of mitotic spindle orientation;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P06782-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06783-1", "uniprot_id": "STE3_YEAST", "mass": 53708.0, "length": 470, "protein_name": "Pheromone a factor receptor", "gene_name": "STE3", "organism": "Yeast", "refseq_name": "Ste3p", "refseq_ac": "NP_012743", "gene_names_uniprotkb": "STE3", "gene_names_refseq": "DAF2; STE3", "protein_names_uniprotkb": "Pheromone a factor receptor", "protein_names_refseq": "Ste3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL178C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16453635;16847258;17322287;18407956;24374639;3006051;33491328;8154185;8196765", "class_list": "", "function": "Receptor for the peptide pheromone a factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX23", "ec_number_list": "", "go_molecular_function": "GO:0004932 mating-type factor pheromone receptor activity;GO:0004933 mating-type a-factor pheromone receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005775 vacuolar lumen", "go_biological_process": "GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion;GO:0000755 cytogamy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P06783-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06784-1", "uniprot_id": "STE7_YEAST", "mass": 57709.0, "length": 515, "protein_name": "Serine/threonine-protein kinase STE7", "gene_name": "STE7", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase kinase STE7", "refseq_ac": "NP_010122", "gene_names_uniprotkb": "STE7; D1525", "gene_names_refseq": "STE7", "protein_names_uniprotkb": "Serine/threonine-protein kinase STE7; 2.7.12.2", "protein_names_refseq": "mitogen-activated protein kinase kinase STE7", "tax_id": 559292, "disease": "cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); RASopathy (Disease Ontology:DOID:0080690); cardiofaciocutaneous syndrome 3 (Disease Ontology:DOID:0111462); cardiofaciocutaneous syndrome 4 (Disease Ontology:DOID:0111463); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); lung adenocarcinoma (Disease Ontology:DOID:3910); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); melorheostosis (Disease Ontology:DOID:4253); renal cell carcinoma (Disease Ontology:DOID:4450); small intestine adenocarcinoma (Disease Ontology:DOID:4906); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83)", "pathway": " (sce:YDL159W); (R-SCE-168638); (R-SCE-2559580); (R-SCE-2871796); (R-SCE-450302); (R-SCE-6811555)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "14562106;1628833;18407956;19779198;24374639;33491328;3532111;8131746;8159759;8972581;9169867", "class_list": "", "function": "Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it is phosphorylated by the ste11 protein kinase and that it can phosphorylate the FUS3 and or KSS1 kinases., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRJ2", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;2.7.1.68;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043332 mating projection tip", "go_biological_process": "GO:0000165 MAPK cascade;GO:0071507 pheromone response MAPK cascade;GO:0000196 cell integrity MAPK cascade;GO:0000749 response to pheromone triggering conjugation with cellular fusion;GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P06784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06785-1", "uniprot_id": "TYSY_YEAST", "mass": 35047.0, "length": 304, "protein_name": "Thymidylate synthase", "gene_name": "CDC21", "organism": "Yeast", "refseq_name": "thymidylate synthase", "refseq_ac": "NP_014717", "gene_names_uniprotkb": "CDC21; CRT9; TMP1; YOR29-25", "gene_names_refseq": "CDC21; CRT9; TMP1", "protein_names_uniprotkb": "Thymidylate synthase; 2.1.1.45; Cell division cycle protein 21; Constitutive RNR3 transcription protein 9; TSase; TS", "protein_names_refseq": "thymidylate synthase", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); digenic dyskeratosis congenita (Disease Ontology:DOID:0060984); urinary bladder cancer (Disease Ontology:DOID:11054); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); cerebral infarction (Disease Ontology:DOID:3526); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YOR074C); (R-SCE-499943)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "1297653;1409658;1608451;17248617;24374639;3020375;3031048;3062362;334734;33491328;3522259;4580573;6287238;7028756;8132557;9133743;9169874", "class_list": "", "function": "Thymidylate synthase required for de novo biosynthesis of pyrimidine deoxyribonucleotides. Required for both nuclear and mitochondrial DNA synthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2D7;Q12694", "ec_number_list": "2.1.1.45", "go_molecular_function": "GO:0004799 thymidylate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0034399 nuclear periphery", "go_biological_process": "GO:0006231 dTMP biosynthetic process;GO:0032259 methylation;GO:0006235 dTTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P06785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06786-1", "uniprot_id": "TOP2_YEAST", "mass": 164215.0, "length": 1428, "protein_name": "DNA topoisomerase 2", "gene_name": "TOP2", "organism": "Yeast", "refseq_name": "DNA topoisomerase 2", "refseq_ac": "NP_014311", "gene_names_uniprotkb": "TOP2; N2244; TOR3", "gene_names_refseq": "TOP2; TOR3; TRF3", "protein_names_uniprotkb": "DNA topoisomerase 2; 5.6.2.2; DNA topoisomerase II", "protein_names_refseq": "DNA topoisomerase 2", "tax_id": 559292, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); penile benign neoplasm (Disease Ontology:DOID:11624); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); cancer (Disease Ontology:DOID:162); B cell deficiency (Disease Ontology:DOID:2115); nephroblastoma (Disease Ontology:DOID:2154); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YNL088W); (R-SCE-4615885)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "10094396;10201398;11907579;12963818;1316274;1332607;14562106;17330950;17563356;18097402;18407956;19684113;19779198;19795423;19823750;20485342;20702584;21126336;21177495;22218487;23022727;23749301;24374639;3017975;32597660;33481703;33491328;33502312;8538787;8740422;9169873;9685374", "class_list": "", "function": "Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W191", "ec_number_list": "5.6.2.2;2.3.2.-", "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000795 synaptonemal complex;GO:0097047 DNA replication termination region", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006325 chromatin organization;GO:0009303 rRNA transcription;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P06786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06787-1", "uniprot_id": "CALM_YEAST", "mass": 16135.0, "length": 147, "protein_name": "Calmodulin", "gene_name": "CMD1", "organism": "Yeast", "refseq_name": "calmodulin", "refseq_ac": "NP_009667", "gene_names_uniprotkb": "CMD1; YBR0904", "gene_names_refseq": "CMD1", "protein_names_uniprotkb": "Calmodulin; CaM", "protein_names_refseq": "calmodulin", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); catecholaminergic polymorphic ventricular tachycardia 4 (Disease Ontology:DOID:0060678); long QT syndrome 16 (Disease Ontology:DOID:0070533); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); long QT syndrome 14 (Disease Ontology:DOID:0110655); long QT syndrome 15 (Disease Ontology:DOID:0110656); Alzheimer's disease (Disease Ontology:DOID:10652); major depressive disorder (Disease Ontology:DOID:1470); cancer (Disease Ontology:DOID:162); substance abuse (Disease Ontology:DOID:302); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YBR109C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10339566;1304352;17322287;17563356;18407956;19779198;19795423;19823750;2044154;21126336;21177495;23749301;24374639;24909858;3295478;33481703;33491328;3533275;7813418;7900426;7918668;8247006;8827436", "class_list": "", "function": "Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQA8", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0051019 mitogen-activated protein kinase binding;GO:0005509 calcium ion binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0030479 actin cortical patch;GO:0000131 incipient cellular bud site;GO:0005823 central plaque of spindle pole body", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0042144 vacuole fusion, non-autophagic;GO:0006897 endocytosis;GO:0007010 cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P06787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06838-1", "uniprot_id": "RAD10_YEAST", "mass": 24311.0, "length": 210, "protein_name": "DNA repair protein RAD10", "gene_name": "RAD10", "organism": "Yeast", "refseq_name": "DNA repair protein RAD10", "refseq_ac": "NP_013614", "gene_names_uniprotkb": "RAD10", "gene_names_refseq": "RAD10", "protein_names_uniprotkb": "DNA repair protein RAD10", "protein_names_refseq": "DNA repair protein RAD10", "tax_id": 559292, "disease": "XFE progeroid syndrome (Disease Ontology:DOID:0060590); cerebrooculofacioskeletal syndrome 4 (Disease Ontology:DOID:0080914); stomach cancer (Disease Ontology:DOID:10534); kidney failure (Disease Ontology:DOID:1074); azoospermia (Disease Ontology:DOID:14227); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myelofibrosis (Disease Ontology:DOID:4971); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YML095C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17989249;24374639;33481703;3896774;3912171;8479526;8621533;9169872", "class_list": "", "function": "Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD1 forms an endonuclease that specifically degrades single-stranded DNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0J0", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003684 damaged DNA binding;GO:0004519 endonuclease activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0005634 nucleus", "go_biological_process": "GO:0006312 mitotic recombination;GO:0000710 meiotic mismatch repair;GO:0000715 nucleotide-excision repair, DNA damage recognition;GO:0006289 nucleotide-excision repair;GO:0000735 removal of nonhomologous ends", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06838-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06839-1", "uniprot_id": "RAD3_YEAST", "mass": 89786.0, "length": 778, "protein_name": "General transcription and DNA repair factor IIH helicase subunit XPD/RAD3", "gene_name": "RAD3", "organism": "Yeast", "refseq_name": "TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3", "refseq_ac": "NP_011098", "gene_names_uniprotkb": "RAD3; REM1", "gene_names_refseq": "RAD3; REM1", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase subunit XPD/RAD3; 5.6.2.3; DNA 5'-3' helicase RAD3; DNA repair helicase RAD3; RNA polymerase II transcription factor B subunit RAD3; TFB subunit RAD3; TFIIH subunit XPD", "protein_names_refseq": "TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3", "tax_id": 559292, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal recessive congenital ichthyosis (Disease Ontology:DOID:0060655); cerebrooculofacioskeletal syndrome 2 (Disease Ontology:DOID:0080912); xeroderma pigmentosum group D (Disease Ontology:DOID:0110845); photosensitive trichothiodystrophy 1 (Disease Ontology:DOID:0111873); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); acoustic neuroma (Disease Ontology:DOID:12689); Down syndrome (Disease Ontology:DOID:14250); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); ovary epithelial cancer (Disease Ontology:DOID:2152); photosensitive trichothiodystrophy (Disease Ontology:DOID:2960); Cockayne syndrome (Disease Ontology:DOID:2962); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); skin disease (Disease Ontology:DOID:37); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YER171W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 23, "publication_id_list": "14500720;14562106;16973432;1719538;1956796;2174856;22411836;24374639;25775526;26483468;27610567;2827162;2846277;2957691;2987851;33491328;3885009;7813015;7961739;8269516;8387143;8631896;9169868", "class_list": "", "function": "ATP-dependent 5'-3' DNA helicase (PubMed:25775526, PubMed:2827162). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/RAD3 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. XPD/RAD3 acts by forming a bridge between TFIIK and the core-TFIIH complex. Involved in the maintenance of the fidelity of DNA replication. Has single-stranded DNA-dependent ATPase activity (PubMed:2957691). 5'-3' DNA helicase activity requires ATP (dATP partially substitutes), will unwind over 800 bp dsDNA (PubMed:2827162). Able to unwind an RNA:DNA hybrid (PubMed:1719538)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM79", "ec_number_list": "2.7.7.6;2.7.11.23;3.6.4.13;5.6.2.3;3.1.-.-;3.6.4.10;3.6.-.-;5.6.2.4;2.7.7.7;3.1.11.-;3.6.4.-;5.6.1.4;2.7.11.22;3.6.4.12;3.6.4.6;5.6.2.5;2.3.2.27;2.1.1.56;3.6.1.-;3.4.24.-;3.6.5.-;2.3.1.48;3.4.19.12;5.2.1.8;2.7.7.50;3.1.3.16;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003684 damaged DNA binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005675 transcription factor TFIIH holo complex;GO:0000112 nucleotide-excision repair factor 3 complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair;GO:0000019 regulation of mitotic recombination;GO:0045951 positive regulation of mitotic recombination", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P06839-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06843-1", "uniprot_id": "SPT2_YEAST", "mass": 38551.0, "length": 333, "protein_name": "Protein SPT2", "gene_name": "SPT2", "organism": "Yeast", "refseq_name": "Spt2p", "refseq_ac": "NP_011088", "gene_names_uniprotkb": "SPT2; SIN1; SPM2", "gene_names_refseq": "EXA1; SIN1; SPT2", "protein_names_uniprotkb": "Protein SPT2; Negative regulator of Ty transcription", "protein_names_refseq": "Spt2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER161C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562106;17563356;18407956;19779198;19795423;19823750;2072912;21177495;22814378;23749301;24374639;26109053;2991744;32597660;33481703;33491328;8654588;8710860;9169868;9885573", "class_list": "", "function": "Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Global regulatory protein that plays positive as well as negative regulatory roles in transcription (PubMed:2072912)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM69", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding;GO:0000217 DNA secondary structure binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0031507 heterochromatin formation;GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P06843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06844-1", "uniprot_id": "SPT3_YEAST", "mass": 38800.0, "length": 337, "protein_name": "SAGA complex subunit SPT3", "gene_name": "SPT3", "organism": "Yeast", "refseq_name": "transcriptional regulator SPT3", "refseq_ac": "NP_010680", "gene_names_uniprotkb": "SPT3; D9509.12", "gene_names_refseq": "SPT3", "protein_names_uniprotkb": "SAGA complex subunit SPT3; Positive regulator of Ty transcription; Suppressor of Ty protein 3", "protein_names_refseq": "transcriptional regulator SPT3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR392W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10026213;10580001;10611242;10864329;11485989;12072450;12186975;12370284;12446794;14562106;15087486;15260971;15647753;18407956;19779198;21177495;22932476;23749301;24374639;25216679;28918903;3020500;31969703;33491328;33864814;9169867;9224714;9674426", "class_list": "", "function": "Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:10580001, PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:11485989). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12186975, PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). SPT3 is required for recruitment of TATA-binding protein (TBP) to SAGA-dependent promoters (PubMed:12370284). During SAGA-mediated transcriptional inhibition, SPT3 and SPT8 prevent binding of TBP to the TATA box (PubMed:10611242). Required for diploid filamentous growth and haploid invasive growth (PubMed:12072450)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT26;Q70DE7;Q70DE9;Q70DF1;Q70DF2", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0006366 transcription by RNA polymerase II;GO:0001403 invasive growth in response to glucose limitation;GO:0007124 pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P06844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07143-1", "uniprot_id": "CY1_YEAST", "mass": 34055.0, "length": 309, "protein_name": "Cytochrome c1, heme protein, mitochondrial", "gene_name": "CYT1", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase catalytic subunit CYT1", "refseq_ac": "NP_014708", "gene_names_uniprotkb": "CYT1; CTC1; YOR29-16", "gene_names_refseq": "CTC1; CYT1; YOR29-16", "protein_names_uniprotkb": "Cytochrome c1, heme protein, mitochondrial; 7.1.1.8; Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Cytochrome c-1; Ubiquinol-cytochrome c oxidoreductase cytochrome c1 subunit", "protein_names_refseq": "ubiquinol--cytochrome-c reductase catalytic subunit CYT1", "tax_id": 559292, "disease": "mitochondrial complex III deficiency nuclear type 6 (Disease Ontology:DOID:0080115)", "pathway": " (sce:YOR065W); (R-SCE-611105); (R-SCE-9865878)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10764779;10775262;10873857;11279090;11880631;14562106;18390544;24374639;30598554;30598556;6092058;9133743;9169874;9430684", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c (PubMed:18390544)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2C8", "ec_number_list": "7.1.1.8;1.1.2.3;7.1.2.2;2.3.3.1;3.4.24.64;4.2.1.3;1.1.1.41;3.6.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07143-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07149-1", "uniprot_id": "FAS1_YEAST", "mass": 228691.0, "length": 2051, "protein_name": "Fatty acid synthase subunit beta", "gene_name": "FAS1", "organism": "Yeast", "refseq_name": "tetrafunctional fatty acid synthase subunit FAS1", "refseq_ac": "NP_012739", "gene_names_uniprotkb": "FAS1", "gene_names_refseq": "FAS1", "protein_names_uniprotkb": "Fatty acid synthase subunit beta; 2.3.1.86", "protein_names_refseq": "tetrafunctional fatty acid synthase subunit FAS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL182W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;17287358;18407956;19779198;2034224;22106047;22814378;23749301;24374639;3031066;32597660;33481703;33491328;3528750;7992503;8154185;8196765", "class_list": "", "function": "Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 51, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX19;Q05747", "ec_number_list": "2.3.1.38;2.3.1.39;3.1.2.14;4.2.1.59;2.3.1.86;1.3.1.9", "go_molecular_function": "GO:0004321 fatty-acyl-CoA synthase activity;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity;GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005835 fatty acid synthase complex", "go_biological_process": "GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P07149-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07170-1", "uniprot_id": "KAD2_YEAST", "mass": 24255.0, "length": 222, "protein_name": "Adenylate kinase", "gene_name": "ADK1", "organism": "Yeast", "refseq_name": "adenylate kinase ADK1", "refseq_ac": "NP_010512", "gene_names_uniprotkb": "ADK1; AKY1; AKY2; AKY; YD9934.11", "gene_names_refseq": "ADK1; AKY1; AKY2", "protein_names_uniprotkb": "Adenylate kinase; 2.7.4.3; ATP-AMP transphosphorylase; ATP:AMP phosphotransferase; Adenylate kinase cytosolic and mitochondrial; Adenylate monophosphate kinase", "protein_names_refseq": "adenylate kinase ADK1", "tax_id": 559292, "disease": "reticular dysgenesis (Disease Ontology:DOID:0060020); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (sce:YDR226W); (R-SCE-499943)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "12045196;14562106;16823961;17322287;17563356;18433446;19779198;22814378;22984289;24374639;2821496;2834097;2848829;2850178;3004985;33481703;33491328;7635152;7670369;7885847;8594191;9169867", "class_list": "", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSK8;Q6Q539", "ec_number_list": "2.7.4.3", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016208 AMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0009117 nucleotide metabolic process;GO:0046034 ATP metabolic process;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P07170-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07213-1", "uniprot_id": "TOM70_YEAST", "mass": 70123.0, "length": 617, "protein_name": "Mitochondrial import receptor subunit TOM70", "gene_name": "TOM70", "organism": "Yeast", "refseq_name": "protein channel TOM70", "refseq_ac": "NP_014278", "gene_names_uniprotkb": "TOM70; MAS70; N1905; OMP1", "gene_names_refseq": "MAS70; MOM72; OMP1; TOM70", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM70; 70 kDa mitochondrial outer membrane protein; Translocase of outer membrane 70 kDa subunit", "protein_names_refseq": "protein channel TOM70", "tax_id": 559292, "disease": "hypothyroidism (Disease Ontology:DOID:1459); congestive heart failure (Disease Ontology:DOID:6000); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YNL121C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10519552;11054285;11502169;14562106;1694969;17287358;17330950;17563356;18407956;18780730;19779198;19795423;19823750;21126336;21215441;2170106;22814378;23749301;24374639;32597660;33481703;33491328;6365533;8380165;9090055;9169873;9774667", "class_list": "", "function": "Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0KZR5;B0KZS4;B0KZU2;B0KZY7;B0KZZ6;B0L005;B0L023;D6W162", "ec_number_list": "", "go_molecular_function": "GO:0015450 protein-transporting ATPase activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0006886 intracellular protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P07213-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07244-1", "uniprot_id": "PUR2_YEAST", "mass": 86068.0, "length": 802, "protein_name": "Bifunctional purine biosynthetic protein ADE5,7", "gene_name": "ADE57", "organism": "Yeast", "refseq_name": "bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase", "refseq_ac": "NP_011280", "gene_names_uniprotkb": "ADE57; ADE5,7", "gene_names_refseq": "ADE57", "protein_names_uniprotkb": "Bifunctional purine biosynthetic protein ADE5,7; AIR synthase; AIR synthetase; AIRS; GAR synthetase; GARS; Glycinamide ribonucleotide synthetase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase", "protein_names_refseq": "bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase", "tax_id": 559292, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (sce:YGL234W); (R-SCE-73817)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562095;14562106;17322287;18407956;19779198;21126336;22814378;23749301;24374639;3097325;32597660;33481703;33491328;33502312;7483834;9169869", "class_list": "", "function": "Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVA0;E9P907", "ec_number_list": "6.3.3.1;6.3.4.13", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004637 phosphoribosylamine-glycine ligase activity;GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006144 purine nucleobase metabolic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0046084 adenine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P07244-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07245-1", "uniprot_id": "C1TC_YEAST", "mass": 102205.0, "length": 946, "protein_name": "C-1-tetrahydrofolate synthase, cytoplasmic", "gene_name": "ADE3", "organism": "Yeast", "refseq_name": "trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3", "refseq_ac": "NP_011720", "gene_names_uniprotkb": "ADE3; G7733", "gene_names_refseq": "ADE3", "protein_names_uniprotkb": "C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase", "protein_names_refseq": "trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3", "tax_id": 559292, "disease": "spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); developmental cardiac valvular defect (Disease Ontology:DOID:0080633); Down syndrome (Disease Ontology:DOID:14250); tetralogy of Fallot (Disease Ontology:DOID:6419); cleft palate (Disease Ontology:DOID:674); abdominal aortic aneurysm (Disease Ontology:DOID:7693); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (sce:YGR204W); (R-SCE-196757)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "14562095;14562106;17322287;17330950;18407956;19779198;20702584;21126336;22218487;22814378;23749301;24374639;2541774;32597660;329838;33481703;33491328;3514599;8464869;8904340;9169869", "class_list": "", "function": "Cytoplasmic isozyme of C-1-tetrahydrofolate synthase. The trifunctional enzyme catalyzes the interconversion of the one-carbon derivatives of tetrahydrofolate (THF) between different oxidation states by the enzymatic activities 10-formyltetrahydrofolate synthetase, 5,lO-methenyltetrahydrofolate cyclohydrolase, and 5,lO-methylenetetrahydrofolate dehydrogenase. Involved in the generation of one-carbon intermediates in the biosynthesis of the purine bases., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUY6", "ec_number_list": "6.3.4.3;1.5.1.5;3.5.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006760 folic acid-containing compound metabolic process;GO:0009113 purine nucleobase biosynthetic process;GO:0035999 tetrahydrofolate interconversion;GO:0000105 L-histidine biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P07245-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07246-1", "uniprot_id": "ADH3_YEAST", "mass": 40370.0, "length": 375, "protein_name": "Alcohol dehydrogenase 3, mitochondrial", "gene_name": "ADH3", "organism": "Yeast", "refseq_name": "alcohol dehydrogenase ADH3", "refseq_ac": "NP_013800", "gene_names_uniprotkb": "ADH3; YM9582.08", "gene_names_refseq": "ADH3", "protein_names_uniprotkb": "Alcohol dehydrogenase 3, mitochondrial; 1.1.1.1; ADHIII; Alcohol dehydrogenase III; YADH-3", "protein_names_refseq": "alcohol dehydrogenase ADH3", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR083W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10940011;1101965;12702265;14562106;17322287;18407956;2188098;22094012;24374639;2937632;2943982;33481703;33491328;3546317;9169872", "class_list": "", "function": "Mitochondrial isozyme that reduces acetaldehyde to ethanol during the fermentation of glucose (Probable) (PubMed:22094012). Involved in the shuttling of mitochondrial reducing equivalents to the cytosol, where the redox balance is restored by NADH dehydrogenases on the external side of the mitochondrial inner membrane (PubMed:10940011). Shows a high affinity for alcohols with a double bond conjugated to the alcohol group (PubMed:1101965)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZQ6", "ec_number_list": "1.1.1.1;1.1.1.54;1.1.1.78;1.1.1.-;1.1.1.284", "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:1990362 butanol dehydrogenase (NAD+) activity;GO:0120542 ethanol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P07246-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07248-1", "uniprot_id": "ADR1_YEAST", "mass": 150941.0, "length": 1323, "protein_name": "Regulatory protein ADR1", "gene_name": "ADR1", "organism": "Yeast", "refseq_name": "DNA-binding transcription factor ADR1", "refseq_ac": "NP_010502", "gene_names_uniprotkb": "ADR1; YD8142.16; YD8142B.08", "gene_names_refseq": "ADR1", "protein_names_uniprotkb": "Regulatory protein ADR1", "protein_names_refseq": "DNA-binding transcription factor ADR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR216W)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10331877;1448103;1549108;15665377;1588970;17287358;17330950;18407956;18791642;1917932;1924382;19398770;19779198;19795423;19823750;2012802;20139423;20489023;21126336;21177495;22218487;23749301;24374639;24909858;3047872;3112579;32597660;33481703;33491328;3515197;8132676;8910470;9169867;9822683", "class_list": "", "function": "Required for transcriptional activation of glucose-repressible alcohol dehydrogenase (ADH2)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 56, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSJ9;Q04919", "ec_number_list": "", "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0060090 molecular adaptor activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007031 peroxisome organization", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P07248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07249-1", "uniprot_id": "ARGR1_YEAST", "mass": 19488.0, "length": 177, "protein_name": "Arginine metabolism regulation protein I", "gene_name": "ARG80", "organism": "Yeast", "refseq_name": "Arg80p", "refseq_ac": "NP_013756", "gene_names_uniprotkb": "ARG80; ARGR1; YM9532.07", "gene_names_refseq": "ARG80; ARGR1", "protein_names_uniprotkb": "Arginine metabolism regulation protein I; Arginine-requiring protein 80", "protein_names_refseq": "Arg80p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR042W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10632874;14562095;17322287;2005902;2017180;2274024;23749301;24374639;3298999;3311884;33481703;33491328;9169872", "class_list": "", "function": "With ARG81, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZL7", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006525 arginine metabolic process;GO:1900079 regulation of arginine biosynthetic process;GO:1900081 regulation of arginine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07249-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07250-1", "uniprot_id": "IPMK_YEAST", "mass": 40353.0, "length": 355, "protein_name": "Inositol polyphosphate multikinase", "gene_name": "ARG82", "organism": "Yeast", "refseq_name": "inositol polyphosphate multikinase", "refseq_ac": "NP_010458", "gene_names_uniprotkb": "ARG82; ARGR3; GSL3; IPK2; YD9395.06C", "gene_names_refseq": "ARG82; ARGR3; IPK2", "protein_names_uniprotkb": "Inositol polyphosphate multikinase; 2.7.1.127; 2.7.1.151; Arginine metabolism regulation protein III; GLE1 synthetic lethal protein 3; IPMK; Inositol polyphosphate kinase 2", "protein_names_refseq": "inositol polyphosphate multikinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR173C); (R-SCE-1855167); (R-SCE-1855191)", "pathway_count": 3, "publication_count": 34, "publication_id_list": "10390371;10574768;10632874;10683435;10720331;11119723;11311242;12434012;12828642;14562106;15944147;16123124;17050532;17322287;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22814378;22992733;23749301;24374639;28923943;3298999;3311884;33481703;33491328;7945194;8043104;9169867", "class_list": "", "function": "Inositol phosphate kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activities. Able to phosphorylate inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) on both the carbon-3 and carbon-6 positions to synthesize inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) and inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), and then to subsequently phosphorylate and convert either isomer of InsP4 to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:10574768, PubMed:10683435, PubMed:11311242). Its predominant in vivo catalytic function is to convert Ins(1,4,5)P3 to Ins(1,4,5,6)P4 to Ins(1,3,4,5,6)P5 via 6- and 3-kinase activities (PubMed:15944147). It can also use Ins(1,3,4,5,6)P5 as a substrate and act as a diphosphoinositol polyphosphate synthase to generate two different isomers of PP-InsP4 (PubMed:11311242). Also has a role in transcription regulation. Forms a complex with ARG80, ARG81 and MCM1 (ArgR-MCM1), which coordinates the expression of arginine anabolic and catabolic genes in response to arginine. Recruits ARG80 and MCM21 to stabilize them (PubMed:10632874, PubMed:3298999, PubMed:8043104). Neither the kinase activity nor inositol phosphates are required for the formation of ArgR-MCM1 transcriptional complexes on DNA promoter elements and the control of arginine metabolism (PubMed:10720331, PubMed:11119723, PubMed:12828642, PubMed:22992733). In contrast, only the catalytic activity is required for PHO gene repression by phosphate and for NCR gene activation in response to nitrogen availability, indicating a role for inositol pyrophosphates in these controls (PubMed:12828642). Inositol polyphosphates may be involved in the regulation of chromatin remodeling of transcription (PubMed:12434012). Regulates nuclear mRNA export via inositol phosphate metabolism (PubMed:10390371, PubMed:10683435). Also has lipid kinase activity, transforming the lipid inositol phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) into phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) in the nucleus (PubMed:16123124). Its kinase activity is necessary for the propagation of most [PSI+] prion variants (PubMed:28923943)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSF5;E9P8S7", "ec_number_list": "2.7.1.127;2.7.1.151;2.7.4.21", "go_molecular_function": "GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016236 macroautophagy;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P07250-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07251-1", "uniprot_id": "ATPA_YEAST", "mass": 58608.0, "length": 545, "protein_name": "ATP synthase subunit alpha, mitochondrial", "gene_name": "ATP1", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit alpha", "refseq_ac": "NP_009453", "gene_names_uniprotkb": "ATP1; YBL0827", "gene_names_refseq": "ATP1", "protein_names_uniprotkb": "ATP synthase subunit alpha, mitochondrial", "protein_names_refseq": "F1F0 ATP synthase subunit alpha", "tax_id": 559292, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 4A (Disease Ontology:DOID:0070461); mitochondrial complex V (ATP synthase) deficiency nuclear type 4B (Disease Ontology:DOID:0070462); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); combined oxidative phosphorylation deficiency 22 (Disease Ontology:DOID:0111498); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pulmonary hypertension (Disease Ontology:DOID:6432); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (sce:YBL099W); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10576729;10744740;11502169;14562106;17322287;17761666;19779198;21126336;23749301;24374639;2876995;32597660;33481703;33491328;7502586;7813418", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPQ6;Q92449", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P07251-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07255-1", "uniprot_id": "COX9_YEAST", "mass": 6963.0, "length": 59, "protein_name": "Cytochrome c oxidase subunit 9, mitochondrial", "gene_name": "COX9", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit VIIa", "refseq_ac": "NP_010216", "gene_names_uniprotkb": "COX9; D2520", "gene_names_refseq": "COX9", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 9, mitochondrial; Cytochrome c oxidase polypeptide VIIA", "protein_names_refseq": "cytochrome c oxidase subunit VIIa", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL067C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10764779;10775262;14562106;17322287;2158998;22814378;24374639;2550765;3013877;3023385;30598554;30598556;7851399;9169867", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRT0", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07255-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07256-1", "uniprot_id": "QCR1_YEAST", "mass": 50228.0, "length": 457, "protein_name": "Cytochrome b-c1 complex subunit 1, mitochondrial", "gene_name": "COR1", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase subunit COR1", "refseq_ac": "NP_009508", "gene_names_uniprotkb": "COR1; QCR1; YBL0403", "gene_names_refseq": "COR1; QCR1", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 1, mitochondrial; Complex III subunit 1; Core protein I; Ubiquinol-cytochrome c oxidoreductase core protein 1; Ubiquinol-cytochrome c reductase 44 kDa protein", "protein_names_refseq": "ubiquinol--cytochrome-c reductase subunit COR1", "tax_id": 559292, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (sce:YBL045C); (R-SCE-611105); (R-SCE-9865878)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10764779;10775262;10873857;11502169;11880631;14562106;14690591;17322287;18390544;18407956;23749301;24374639;3023384;30598554;30598556;33481703;33491328;7813418;7871888", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPV3", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P07256-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07257-1", "uniprot_id": "QCR2_YEAST", "mass": 40478.0, "length": 368, "protein_name": "Cytochrome b-c1 complex subunit 2, mitochondrial", "gene_name": "QCR2", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase subunit 2", "refseq_ac": "NP_015517", "gene_names_uniprotkb": "QCR2; COR2; P9677.6; UCR2", "gene_names_refseq": "COR2; QCR2; UCR2", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 2, mitochondrial; Complex III subunit 2; Core protein II; Ubiquinol-cytochrome c oxidoreductase core protein 2", "protein_names_refseq": "ubiquinol--cytochrome-c reductase subunit 2", "tax_id": 559292, "disease": "chromosome 16p12.1 deletion syndrome (Disease Ontology:DOID:0060399); mitochondrial complex III deficiency nuclear type 5 (Disease Ontology:DOID:0080114)", "pathway": " (sce:YPR191W); (R-SCE-9865878)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10764779;10775262;10873857;11502169;11880631;14562106;17322287;17761666;18390544;19779198;21126336;22984289;24374639;3028797;30598554;30598556;33481703;33491328;9169875", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4J1", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0006508 proteolysis;GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P07257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07259-1", "uniprot_id": "PYR1_YEAST", "mass": 245041.0, "length": 2214, "protein_name": "Multifunctional protein URA2", "gene_name": "URA2", "organism": "Yeast", "refseq_name": "bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase", "refseq_ac": "NP_012405", "gene_names_uniprotkb": "URA2; J0686", "gene_names_refseq": "URA2", "protein_names_uniprotkb": "Multifunctional protein URA2; Aspartate transcarbamylase; CPS-P; CPSase P; CPSase-ATCase; CPSase-ura; Carbamoyl phosphate synthase P; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; Pyrimidine-specific carbamoyl phosphate synthase", "protein_names_refseq": "bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase", "tax_id": 559292, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); developmental and epileptic encephalopathy 50 (Disease Ontology:DOID:0080419); rhabdomyosarcoma (Disease Ontology:DOID:3247); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280)", "pathway": " (sce:YJL130C); (R-SCE-500753)", "pathway_count": 2, "publication_count": 42, "publication_id_list": "10446140;11015727;11921093;14562095;14562106;15128434;15665377;17244705;17287358;17330950;17351133;17563356;182284;18407956;1977585;19779198;21126336;22106047;22814378;23749301;237624;24374639;2498313;2570735;27821475;3039294;32597660;3281587;33481703;33491328;4575349;5552824;5856369;6354093;7660977;8117117;8449292;8641269;8813765;8948101;9150260;9489999", "class_list": "", "function": "Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2TBN0;D6VW55;Q06HN1", "ec_number_list": "6.3.4.16;6.3.5.5;2.1.3.2;3.5.1.2;4.3.2.10;4.3.3.6", "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006541 glutamine metabolic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process;GO:0045984 negative regulation of pyrimidine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P07259-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07260-1", "uniprot_id": "IF4E_YEAST", "mass": 24254.0, "length": 213, "protein_name": "Eukaryotic translation initiation factor 4E", "gene_name": "CDC33", "organism": "Yeast", "refseq_name": "translation initiation factor eIF4E", "refseq_ac": "NP_014502", "gene_names_uniprotkb": "CDC33; TIF45", "gene_names_refseq": "CDC33; TIF45", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; eIF4E; mRNA cap-binding protein", "protein_names_refseq": "translation initiation factor eIF4E", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); candidiasis (Disease Ontology:DOID:1508); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (sce:YOL139C); (R-SCE-156827); (R-SCE-429947); (R-SCE-72649); (R-SCE-72662); (R-SCE-72702)", "pathway_count": 6, "publication_count": 31, "publication_id_list": "11741542;14562106;15665377;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22106047;23749301;24374639;2685552;30516470;3062383;32027465;32597660;33481703;33491328;34965436;3550438;7502581;7592868;8119957;9169874;9302999", "class_list": "", "function": "Recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1T0", "ec_number_list": "", "go_molecular_function": "GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0098808 mRNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0005840 ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006413 translational initiation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006446 regulation of translational initiation;GO:0051726 regulation of cell cycle;GO:1901195 positive regulation of formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P07260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07261-1", "uniprot_id": "GCR1_YEAST", "mass": 87729.0, "length": 785, "protein_name": "Glycolytic genes transcriptional activator GCR1", "gene_name": "GCR1", "organism": "Yeast", "refseq_name": "transcription regulator GCR1", "refseq_ac": "NP_015250", "gene_names_uniprotkb": "GCR1; LPF10W; SIT3", "gene_names_refseq": "GCR1; LPF10; SIT3", "protein_names_uniprotkb": "Glycolytic genes transcriptional activator GCR1", "protein_names_refseq": "transcription regulator GCR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL075W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11333224;14562106;1508187;1588965;17563356;18407956;19779198;23749301;24374639;3025612;32597660;33229814;33481703;33491328;3547083;7851789;8508768;8601472;9169875;9335588", "class_list": "", "function": "Transcriptional activator required for the expression of glycolytic and ribosomal genes. Forms a transcriptional activation complex with RAP1, RAP1 providing the specific DNA-binding function and GCR1 providing the activation function. Can also bind itself to DNA to a core 5'-CTTCC-3' sequence (CT box). CT box-binding is not essential, but enhances the activation function of the RAP1-GCR1 complex in promoters that contain both DNA signals (only glycolytic genes). CT box-dependent transcriptional activation requires GCR2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W3U1", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0034728 nucleosome organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006110 regulation of glycolytic process;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P07261-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07263-1", "uniprot_id": "SYH_YEAST", "mass": 59953.0, "length": 546, "protein_name": "Histidine--tRNA ligase, mitochondrial", "gene_name": "HTS1", "organism": "Yeast", "refseq_name": "histidine--tRNA ligase", "refseq_ac": "NP_015358", "gene_names_uniprotkb": "HTS1; YP9367.13C", "gene_names_refseq": "HTS1; TS4572; TSM4572", "protein_names_uniprotkb": "Histidine--tRNA ligase, mitochondrial; 6.1.1.21; HisRS; Histidyl-tRNA synthetase", "protein_names_refseq": "histidine--tRNA ligase", "tax_id": 559292, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); Perrault syndrome 2 (Disease Ontology:DOID:0061117); Charcot-Marie-Tooth disease, axonal type 2W (Disease Ontology:DOID:0110162); Usher syndrome type 3B (Disease Ontology:DOID:0110842); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (sce:YPR033C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;1459448;17322287;21464306;23749301;24374639;33481703;33491328;3521891;9169875", "class_list": "", "function": "Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W443;Q12095", "ec_number_list": "6.1.1.21", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P07263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07264-1", "uniprot_id": "LEUC_YEAST", "mass": 85794.0, "length": 779, "protein_name": "3-isopropylmalate dehydratase", "gene_name": "LEU1", "organism": "Yeast", "refseq_name": "3-isopropylmalate dehydratase LEU1", "refseq_ac": "NP_011506", "gene_names_uniprotkb": "LEU1", "gene_names_refseq": "LEU1", "protein_names_uniprotkb": "3-isopropylmalate dehydratase; 4.2.1.33; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase", "protein_names_refseq": "3-isopropylmalate dehydratase LEU1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL009C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;15665377;17287358;17330950;17563356;1840714;18407956;1882553;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;24374639;30516470;32597660;33481703;33491328;6323436;9169869", "class_list": "", "function": "Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUC8", "ec_number_list": "4.2.1.33", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003861 3-isopropylmalate dehydratase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0009316 3-isopropylmalate dehydratase complex", "go_biological_process": "GO:0009098 L-leucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P07264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07267-1", "uniprot_id": "CARP_YEAST", "mass": 44499.0, "length": 405, "protein_name": "Saccharopepsin", "gene_name": "PEP4", "organism": "Yeast", "refseq_name": "proteinase A", "refseq_ac": "NP_015171", "gene_names_uniprotkb": "PEP4; P2585; PHO9; PRA1", "gene_names_refseq": "PEP4; PHO9; PRA1; yscA", "protein_names_uniprotkb": "Saccharopepsin; 3.4.23.25; Aspartate protease; Carboxypeptidase Y-deficient protein 4; PrA; Proteinase A; Proteinase YSCA", "protein_names_refseq": "proteinase A", "tax_id": 559292, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); atrial fibrillation (Disease Ontology:DOID:0060224); autosomal dominant tubulointerstitial kidney disease 4 (Disease Ontology:DOID:0061119); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); COVID-19 (Disease Ontology:DOID:0080600); human cytomegalovirus infection (Disease Ontology:DOID:0080827); neuronal ceroid lipofuscinosis 10 (Disease Ontology:DOID:0110725); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hand, foot and mouth disease (Disease Ontology:DOID:10881); primary biliary cholangitis (Disease Ontology:DOID:12236); toxic shock syndrome (Disease Ontology:DOID:14115); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); acute kidney failure (Disease Ontology:DOID:3021); atopic dermatitis (Disease Ontology:DOID:3310); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic fatigue syndrome (Disease Ontology:DOID:8544); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YPL154C); (R-SCE-2132295); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1618910;1959673;24374639;3023936;33481703;3537721;8840499;8948103;9135120;9169875", "class_list": "", "function": "Aspartyl protease implicated in the post-translational regulation of S.cerevisiae vacuolar proteinases. Acts on YSCB, on YSCY and on itself., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W3L4", "ec_number_list": "2.7.1.40;3.5.3.1;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;2.3.1.16;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;3.5.1.3;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.2.1.14;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0008233 peptidase activity;GO:0097718 disordered domain specific binding;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0032991 protein-containing complex;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0051603 proteolysis involved in protein catabolic process;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0000425 pexophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07269-1", "uniprot_id": "PHO2_YEAST", "mass": 63391.0, "length": 559, "protein_name": "Regulatory protein PHO2", "gene_name": "PHO2", "organism": "Yeast", "refseq_name": "Pho2p", "refseq_ac": "NP_010177", "gene_names_uniprotkb": "PHO2; BAS2; D2350; GRF10", "gene_names_refseq": "BAS2; GRF10; PHO2", "protein_names_uniprotkb": "Regulatory protein PHO2; General regulatory factor 10", "protein_names_refseq": "Pho2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL106C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10884387;12136204;12219216;12232617;14562106;18407956;23749301;24374639;2896548;3029672;3049251;33491328;8896274;9169867", "class_list": "", "function": "Regulator in phosphate metabolism and acts as a derepressor of another central regulator PHO5. Binds to the upstream activator sequence (UAS) of PHO5. It also binds to the TRP4, HIS4, and CYC1 promoters., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRP4", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07270-1", "uniprot_id": "PHO4_YEAST", "mass": 34089.0, "length": 312, "protein_name": "Phosphate system positive regulatory protein PHO4", "gene_name": "PHO4", "organism": "Yeast", "refseq_name": "phosphate-sensing transcription factor PHO4", "refseq_ac": "NP_116692", "gene_names_uniprotkb": "PHO4", "gene_names_refseq": "PHO4", "protein_names_uniprotkb": "Phosphate system positive regulatory protein PHO4", "protein_names_refseq": "phosphate-sensing transcription factor PHO4", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR034C)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10320381;11237614;14624238;16825185;17287358;17322287;17330950;17467953;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;2183025;2220078;22218487;23749301;24374639;2505053;3008105;30206180;32597660;33481703;33491328;7670463;7957107;8108735;8187772;8539622;8686381;9303313", "class_list": "", "function": "Transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions. Binds to the upstream activating sequence (UAS) of several phosphatase encoding PHO genes. Inhibited by the cyclin-CDK PHO80-PHO85 under high-phosphate conditions., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTR7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016036 cellular response to phosphate starvation", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P07270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07271-1", "uniprot_id": "PIF1_YEAST", "mass": 97682.0, "length": 859, "protein_name": "ATP-dependent DNA helicase PIF1", "gene_name": "PIF1", "organism": "Yeast", "refseq_name": "DNA helicase PIF1", "refseq_ac": "NP_013650", "gene_names_uniprotkb": "PIF1; TST1; YM9958.01C", "gene_names_refseq": "PIF1; TST1", "protein_names_uniprotkb": "ATP-dependent DNA helicase PIF1; 5.6.2.3; DNA 5'-3' helicase PIF1; DNA repair and recombination helicase PIF1; Petite integration frequency protein 1; Telomere stability protein 1", "protein_names_refseq": "DNA helicase PIF1", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); progeria (Disease Ontology:DOID:3911)", "pathway": " (sce:YML061C)", "pathway_count": 1, "publication_count": 41, "publication_id_list": "10693764;10926538;11429610;12024022;14562095;14562106;14576278;15907372;15923634;16121131;16537895;16816432;16878131;17257907;17563356;17590086;17720711;18407956;1849081;19424434;19779198;19838171;20225162;20655619;20795654;21620135;22927468;23175612;23446274;23596008;23657261;23749301;24374639;3038524;30516470;32597660;33481703;33491328;8253734;8287473;9169872", "class_list": "", "function": "DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP. Processes at an unwinding rate of about 75 bp/s. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replication fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZB2", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P07271-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07273-1", "uniprot_id": "TFS2_YEAST", "mass": 34843.0, "length": 309, "protein_name": "Transcription elongation factor S-II", "gene_name": "DST1", "organism": "Yeast", "refseq_name": "transcription elongation factor DST1", "refseq_ac": "NP_011472", "gene_names_uniprotkb": "DST1; PPR2", "gene_names_refseq": "DST1; PPR2", "protein_names_uniprotkb": "Transcription elongation factor S-II; DNA strand transfer protein alpha; DNA strand transferase 1; Pyrimidine pathway regulatory protein 2; STP-alpha", "protein_names_refseq": "transcription elongation factor DST1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL043W); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "14562106;1618824;18407956;1850099;1922360;1971423;19779198;20190278;21126336;23749301;24374639;33491328;6139279;9169869;9234674", "class_list": "", "function": "Can promote the transfer of one strand of a double-stranded DNA molecule to a homologous single strand and thus may be involved in recombination., [UniProtKB]; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU96;P24535", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding;GO:0003711 transcription elongation factor activity;GO:0001139 RNA polymerase II complex recruiting activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P07273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07274-1", "uniprot_id": "PROF_YEAST", "mass": 13677.0, "length": 126, "protein_name": "Profilin", "gene_name": "PFY1", "organism": "Yeast", "refseq_name": "profilin", "refseq_ac": "NP_014765", "gene_names_uniprotkb": "PFY1; CLS5; O3275; PFY; PRF1; YOR3275C", "gene_names_refseq": "CLS5; PFY1; PRF1", "protein_names_uniprotkb": "Profilin; Calcium sensitive protein 5", "protein_names_refseq": "profilin", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); amyotrophic lateral sclerosis type 18 (Disease Ontology:DOID:0060209); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myopathy (Disease Ontology:DOID:423)", "pathway": " (sce:YOR122C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10953013;11014808;12134165;1606973;21126336;23708467;23749301;2404021;24374639;3072473;3317275;33491328;7592954;8247001;8422937;8889515;8904341;8977127;9169874;9200815;9698363", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton (PubMed:1606973, PubMed:8422937). Actin is inherently unstable in vivo at high temperatures, and profilin helps to maintain actin in its filamentous state at these temperatures, perhaps by stimulating actin polymerization in a proper temporal and spatial fashion. Profilin is not essential for maintaining F-actin concentrations during steady-state growth (PubMed:8977127). Mediates actin nucleation by an Arp2p/Arp3p-independent mechanism, and can sequester actin monomers, thereby reducing polymerization ability (PubMed:12134165, PubMed:1606973). Profilin also promotes rapid actin dynamics by regenerating ATP actin from ADP actin-cofilin generated during filament disassembly (PubMed:10953013, PubMed:9698363). May link signaling pathways to actin cytoskeleton organization by binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and to polyproline stretches on several proteins (PubMed:10953013, PubMed:8247001, PubMed:9698363). Profilin is also involved in Ca(2+) regulation in two ways: the first is Ca(2+) homeostasis by coordination with BNI1, BEM1, RHO1, and CLA4, and the second is the requirement of Ca(2+) for bud formation by coordination with BEM1 and CDC24 (PubMed:23708467, PubMed:8889515)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2I0", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070064 proline-rich region binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:1903475 mitotic actomyosin contractile ring assembly;GO:0090338 positive regulation of formin-nucleated actin cable assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P07274-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07276-1", "uniprot_id": "RAD2_YEAST", "mass": 117838.0, "length": 1031, "protein_name": "DNA repair protein RAD2", "gene_name": "RAD2", "organism": "Yeast", "refseq_name": "ssDNA endodeoxyribonuclease RAD2", "refseq_ac": "NP_011774", "gene_names_uniprotkb": "RAD2", "gene_names_refseq": "RAD2", "protein_names_uniprotkb": "DNA repair protein RAD2; 3.1.-.-", "protein_names_refseq": "ssDNA endodeoxyribonuclease RAD2", "tax_id": 559292, "disease": "disease by infectious agent (Disease Ontology:DOID:0050117); xeroderma pigmentosum (Disease Ontology:DOID:0050427); cerebrooculofacioskeletal syndrome 3 (Disease Ontology:DOID:0080913); xeroderma pigmentosum group G (Disease Ontology:DOID:0110849); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); larynx cancer (Disease Ontology:DOID:2596); Cockayne syndrome (Disease Ontology:DOID:2962); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YGR258C); (R-SCE-6782135)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14562106;17322287;18407956;19779198;20489023;23749301;24374639;3000874;3011752;33481703;33491328;8247134;9090059;9169869", "class_list": "", "function": "Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV38;E9P8X9", "ec_number_list": "2.7.7.6;2.7.11.23;5.6.2.3;3.1.-.-;2.7.7.7;3.1.11.-;2.3.2.27;3.6.4.-;3.4.19.12;5.2.1.8;5.6.2.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004520 DNA endonuclease activity;GO:0003697 single-stranded DNA binding;GO:0000014 single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000112 nucleotide-excision repair factor 3 complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07276-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07277-1", "uniprot_id": "ERG12_YEAST", "mass": 48460.0, "length": 443, "protein_name": "Mevalonate kinase", "gene_name": "ERG12", "organism": "Yeast", "refseq_name": "mevalonate kinase", "refseq_ac": "NP_013935", "gene_names_uniprotkb": "ERG12; RAR1; YM8261.02", "gene_names_refseq": "ERG12; RAR1", "protein_names_uniprotkb": "Mevalonate kinase; 2.7.1.36; Ergosterol biosynthesis protein 12; MK; MvK; Regulation of autonomous replication protein 1", "protein_names_refseq": "mevalonate kinase", "tax_id": 559292, "disease": "mevalonic aciduria (Disease Ontology:DOID:0050452); hyperimmunoglobulinemia D periodic fever syndrome (Disease Ontology:DOID:0081450); cancer (Disease Ontology:DOID:162); lipid metabolism disorder (Disease Ontology:DOID:3146); porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (sce:YMR208W); (R-SCE-9969896)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;1645230;20489023;24374639;32679672;3323847;33491328;9169872", "class_list": "", "function": "Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:1645230). ERG12 converts mevalonate into 5-phosphomevalonate (PubMed:1645230). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W033", "ec_number_list": "2.7.1.36", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004496 mevalonate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07277-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07278-1", "uniprot_id": "KAPR_YEAST", "mass": 47219.0, "length": 416, "protein_name": "cAMP-dependent protein kinase regulatory subunit", "gene_name": "BCY1", "organism": "Yeast", "refseq_name": "cAMP-dependent protein kinase regulatory subunit BCY1", "refseq_ac": "NP_012231", "gene_names_uniprotkb": "BCY1; REG1; SRA1", "gene_names_refseq": "BCY1; SRA1", "protein_names_uniprotkb": "cAMP-dependent protein kinase regulatory subunit; Bypass of cyclase mutations protein 1; PKA regulatory subunit; Protein kinase A regulatory subunit; cAPK regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase regulatory subunit BCY1", "tax_id": 559292, "disease": "granulosa cell tumor (Disease Ontology:DOID:2999); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (sce:YIL033C); (R-SCE-163615); (R-SCE-164378); (R-SCE-180024); (R-SCE-432040); (R-SCE-442720); (R-SCE-5610787); (R-SCE-9634597); (R-SCE-983231); (R-SCE-9856530)", "pathway_count": 10, "publication_count": 33, "publication_id_list": "11134339;11875433;12704202;1339314;14562095;14562106;1655793;17287358;17322287;17330950;17563356;18407956;19684113;19779198;20489023;20702584;20826609;21070946;21177495;21311222;22218487;23749301;24374639;2823100;3037314;30516470;32597660;33481703;33491328;34965436;3547325;6243658;9169870", "class_list": "", "function": "Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), an effector of the Ras/cAMP pathway. Inhibits PKA activity in the absence of cAMP. cAMP activates PKA and promotes growth and proliferation in response to good nutrient conditions. Together with ZDS1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVP9", "ec_number_list": "", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0042802 identical protein binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042149 cellular response to glucose starvation;GO:0010603 regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P07278-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07280-1", "uniprot_id": "RS19A_YEAST", "mass": 15917.0, "length": 144, "protein_name": "Small ribosomal subunit protein eS19A", "gene_name": "RPS19A", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS19 RPS19A", "refseq_ac": "NP_014520", "gene_names_uniprotkb": "RPS19A; RP55A; RPS16AA", "gene_names_refseq": "RPS19A", "protein_names_uniprotkb": "Small ribosomal subunit protein eS19A; 40S ribosomal protein S19-A; RP55A; S16a; YP45; YS16A", "protein_names_refseq": "40S ribosomal protein eS19 RPS19A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 1 (Disease Ontology:DOID:0111895); aplastic anemia (Disease Ontology:DOID:12449); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (sce:YOL121C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 20, "publication_id_list": "14562095;14562106;16159874;17726054;19795423;19823750;21109664;21126336;22096102;22218487;24374639;24524803;27821475;32597660;33491328;6387623;6814480;8896268;9169874;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS19 is required for proper maturation of the small (40S) ribosomal subunit. Binds to 40S pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA (PubMed:16159874, PubMed:17726054)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1U7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P07280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07281-1", "uniprot_id": "RS19B_YEAST", "mass": 15891.0, "length": 144, "protein_name": "Small ribosomal subunit protein eS19B", "gene_name": "RPS19B", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS19 RPS19B", "refseq_ac": "NP_014097", "gene_names_uniprotkb": "RPS19B; N0422; RP55B; RPS16AB", "gene_names_refseq": "RP55B; RPS19B", "protein_names_uniprotkb": "Small ribosomal subunit protein eS19B; 40S ribosomal protein S19-B; RP55B; S16a; YS16B", "protein_names_refseq": "40S ribosomal protein eS19 RPS19B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 1 (Disease Ontology:DOID:0111895); aplastic anemia (Disease Ontology:DOID:12449); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (sce:YNL302C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 21, "publication_id_list": "10601260;14562095;14562106;16159874;17287358;18407956;19779198;21177495;22096102;22218487;23749301;24374639;24524803;27821475;32597660;33491328;6387623;6814480;8553702;9169873;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS19 is required for proper maturation of the small (40S) ribosomal subunit. Binds to 40S pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA (PubMed:16159874)., [UniProtKB, PubMed, PubMed]; Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0P2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P07281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07283-1", "uniprot_id": "PMM_YEAST", "mass": 29063.0, "length": 254, "protein_name": "Phosphomannomutase", "gene_name": "SEC53", "organism": "Yeast", "refseq_name": "phosphomannomutase SEC53", "refseq_ac": "NP_116609", "gene_names_uniprotkb": "SEC53; ALG4", "gene_names_refseq": "ALG4; SEC53", "protein_names_uniprotkb": "Phosphomannomutase; 5.4.2.8; Asparagine-linked glycosylation protein 4; PMM", "protein_names_refseq": "phosphomannomutase SEC53", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (sce:YFL045C); (R-SCE-446205)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562106;15087486;17322287;17330950;17563356;18407956;19779198;20702584;23749301;24374639;3288631;33481703;33491328;3905826;7037780;7670463", "class_list": "", "function": "Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions such as folding and glycosylation of secretory proteins in the ER lumen., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTI5;Q70D76;Q70D77", "ec_number_list": "5.4.2.8", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0016853 isomerase activity;GO:0004615 phosphomannomutase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0006013 mannose metabolic process;GO:0009298 GDP-mannose biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P07283-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07286-1", "uniprot_id": "GPT_YEAST", "mass": 50368.0, "length": 448, "protein_name": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "gene_name": "ALG7", "organism": "Yeast", "refseq_name": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "refseq_ac": "NP_009802", "gene_names_uniprotkb": "ALG7; TUR1; YBR1628", "gene_names_refseq": "ALG7; TUR1", "protein_names_uniprotkb": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; 2.7.8.15; G1PT; GPT; GlcNAc-1-P transferase; N-acetylglucosamine-1-phosphate transferase; Tunicamycin resistance protein 1", "protein_names_refseq": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "tax_id": 559292, "disease": "congenital disorder of glycosylation Ij (Disease Ontology:DOID:0080562); congenital myasthenic syndrome 13 (Disease Ontology:DOID:0110676)", "pathway": " (sce:YBR243C); (R-SCE-446193)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "24374639;3033607;6096695;7813418", "class_list": "", "function": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transferring GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQN9", "ec_number_list": "2.7.8.15", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07286-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07342-1", "uniprot_id": "ILVB_YEAST", "mass": 74937.0, "length": 687, "protein_name": "Acetolactate synthase catalytic subunit, mitochondrial", "gene_name": "ILV2", "organism": "Yeast", "refseq_name": "acetolactate synthase catalytic subunit", "refseq_ac": "NP_013826", "gene_names_uniprotkb": "ILV2; SMR1; YM9718.07", "gene_names_refseq": "ILV2; SMR1; THI1", "protein_names_uniprotkb": "Acetolactate synthase catalytic subunit, mitochondrial; 2.2.1.6; AHAS; ALS; Acetohydroxy-acid synthase catalytic subunit", "protein_names_refseq": "acetolactate synthase catalytic subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR108W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10213630;11902841;12496246;14562106;17322287;18407956;23749301;24374639;2989783;33481703;33491328;9169872", "class_list": "", "function": "Catalytic subunit of mitochondrial acetolactate synthase, which catalyzes the first of a series of common steps in the biosynthesis of the branched-chain amino acids. Catalyzes the irreversible decarboxylation of pyruvate to a bound hydroxyethyl group that then condenses with either a second pyruvate molecule to form 2-acetolactate (AL) or with 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate (AHB). The first product is the precursor for valine and leucine biosynthesis, while the second leads to isoleucine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZT1", "ec_number_list": "2.2.1.6", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0030976 thiamine pyrophosphate binding;GO:0003984 acetolactate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005948 acetolactate synthase complex", "go_biological_process": "GO:0009082 branched-chain amino acid biosynthetic process;GO:0009099 L-valine biosynthetic process;GO:0009097 isoleucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07347-1", "uniprot_id": "ARD1_YEAST", "mass": 27603.0, "length": 238, "protein_name": "N-terminal acetyltransferase A complex catalytic subunit ARD1", "gene_name": "ARD1", "organism": "Yeast", "refseq_name": "peptide alpha-N-acetyltransferase complex A subunit ARD1", "refseq_ac": "NP_011877", "gene_names_uniprotkb": "ARD1", "gene_names_refseq": "ARD1; NAA10", "protein_names_uniprotkb": "N-terminal acetyltransferase A complex catalytic subunit ARD1; 2.3.1.255; Arrest-defective protein 1; NatA complex subunit ARD1", "protein_names_refseq": "peptide alpha-N-acetyltransferase complex A subunit ARD1", "tax_id": 559292, "disease": "Ogden syndrome (Disease Ontology:DOID:0050781); syndromic microphthalmia 1 (Disease Ontology:DOID:0111799)", "pathway": " (sce:YHR013C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14517307;14562095;14562106;1600941;17322287;24374639;2551674;33491328;3907857;8091229", "class_list": "", "function": "Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV8", "ec_number_list": "2.3.1.255", "go_molecular_function": "GO:0042802 identical protein binding;GO:1990189 protein N-terminal-serine acetyltransferase activity;GO:1990190 protein-N-terminal-glutamate acetyltransferase activity;GO:0008999 protein-N-terminal-alanine acetyltransferase activity", "go_cellular_component": "GO:0031415 NatA complex", "go_biological_process": "GO:0006474 N-terminal protein amino acid acetylation;GO:0061606 N-terminal protein amino acid propionylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P07347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07560-1", "uniprot_id": "SEC4_YEAST", "mass": 23506.0, "length": 215, "protein_name": "Ras-related protein SEC4", "gene_name": "SEC4", "organism": "Yeast", "refseq_name": "Rab family GTPase SEC4", "refseq_ac": "NP_116650", "gene_names_uniprotkb": "SEC4; SRO6", "gene_names_refseq": "SEC4; SRO6", "protein_names_uniprotkb": "Ras-related protein SEC4; Suppressor of RHO3 protein 6", "protein_names_refseq": "Rab family GTPase SEC4", "tax_id": 559292, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (sce:YFL005W); (R-SCE-6798695); (R-SCE-8873719); (R-SCE-8876198)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "11099382;11785952;11875433;11943201;16390997;17322287;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;21931684;22218487;23749301;24374639;27621363;32597660;33481703;33491328;3552249;7670463;8789262;9199166", "class_list": "", "function": "Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTM4", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P07560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07702-1", "uniprot_id": "LYS2_YEAST", "mass": 155346.0, "length": 1392, "protein_name": "L-2-aminoadipate reductase", "gene_name": "LYS2", "organism": "Yeast", "refseq_name": "L-aminoadipate-semialdehyde dehydrogenase", "refseq_ac": "NP_009673", "gene_names_uniprotkb": "LYS2; YBR0910", "gene_names_refseq": "LYS2", "protein_names_uniprotkb": "L-2-aminoadipate reductase; 1.2.1.31; 1.2.1.95; Alpha-AR; Alpha-aminoadipate reductase; L-aminoadipate-semialdehyde dehydrogenase", "protein_names_refseq": "L-aminoadipate-semialdehyde dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR115C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10320345;14562106;1626431;18407956;2013406;21126336;22106047;24374639;33481703;33491328;3542721;7813418;7900426;7916691", "class_list": "", "function": "Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQB4", "ec_number_list": "1.2.1.31;1.2.1.95", "go_molecular_function": "GO:0031177 phosphopantetheine binding;GO:0004043 L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019878 lysine biosynthetic process via aminoadipic acid", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07702-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07703-1", "uniprot_id": "RPAC1_YEAST", "mass": 37687.0, "length": 335, "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC1", "gene_name": "RPC40", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase core subunit RPC40", "refseq_ac": "NP_015435", "gene_names_uniprotkb": "RPC40; P8283.18; RPC5", "gene_names_refseq": "RPC40; RPC5", "protein_names_uniprotkb": "DNA-directed RNA polymerases I and III subunit RPAC1; AC40; C37; C40; DNA-directed RNA polymerases I and III 40 kDa polypeptide; RNA polymerases I and III subunit AC1", "protein_names_refseq": "DNA-directed RNA polymerase core subunit RPC40", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 11 (Disease Ontology:DOID:0060792); Treacher Collins syndrome 2 (Disease Ontology:DOID:0080790); Treacher Collins syndrome 3 (Disease Ontology:DOID:0080791); Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (sce:YPR110C); (R-SCE-73762); (R-SCE-73772); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "10384303;10393904;11717393;12407181;14562095;14562106;18160037;18407956;19779198;21126336;22814378;24153182;24153184;24374639;25931562;32597660;33481703;33491328;3815519;8516295;9169875", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (PubMed:18160037, PubMed:24153182, PubMed:24153184). Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage (PubMed:25931562)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4A9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P07703-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07834-1", "uniprot_id": "CDC4_YEAST", "mass": 86090.0, "length": 779, "protein_name": "Cell division control protein 4", "gene_name": "CDC4", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase complex subunit CDC4", "refseq_ac": "NP_116585", "gene_names_uniprotkb": "CDC4", "gene_names_refseq": "CDC4", "protein_names_uniprotkb": "Cell division control protein 4; E3 ubiquitin ligase complex SCF subunit CDC4; F-box protein CDC4", "protein_names_refseq": "SCF ubiquitin ligase complex subunit CDC4", "tax_id": 559292, "disease": "developmental delay, hypotonia, and impaired language (Disease Ontology:DOID:0070420)", "pathway": " (sce:YFL009W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10213692;10385629;10409741;11080155;11500370;14747994;17434132;18407956;19779198;19795423;19823750;20489023;21177495;23749301;24374639;32597660;3309335;33481703;33491328;7670463;7813440;8706131;9312022;9312054;9346238;9346239;9499404;9736614", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTM1", "ec_number_list": "", "go_molecular_function": "GO:0050815 phosphoserine residue binding;GO:0043130 ubiquitin binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016363 nuclear matrix;GO:0019005 SCF ubiquitin ligase complex;GO:0043224 nuclear SCF ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P07834-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07866-1", "uniprot_id": "LTE1_YEAST", "mass": 163150.0, "length": 1435, "protein_name": "Guanine nucleotide exchange factor LTE1", "gene_name": "LTE1", "organism": "Yeast", "refseq_name": "mitotic regulator LTE1", "refseq_ac": "NP_009378", "gene_names_uniprotkb": "LTE1; EIS4; MSI2", "gene_names_refseq": "LTE1; MSI2", "protein_names_uniprotkb": "Guanine nucleotide exchange factor LTE1; Low temperature essential protein 1", "protein_names_refseq": "mitotic regulator LTE1", "tax_id": 559292, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); leukocyte adhesion deficiency 3 (Disease Ontology:DOID:0110912); platelet-type bleeding disorder 18 (Disease Ontology:DOID:0111051); familial adult myoclonic epilepsy 7 (Disease Ontology:DOID:0111694); immunodeficiency 64 (Disease Ontology:DOID:0111980); hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YAL024C); (R-SCE-193648); (R-SCE-354192); (R-SCE-381676); (R-SCE-392517); (R-SCE-416482); (R-SCE-9013149)", "pathway_count": 7, "publication_count": 36, "publication_id_list": "10219244;10929710;11101520;11285282;11493673;12234925;12432084;12498684;12699621;12782684;14562095;14562106;14718561;15197338;17121813;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;3045810;30516470;32597660;3332963;33481703;33491328;7731988;7935462;7941731;7985422", "class_list": "", "function": "GDP-GTP exchange factor for TEM1, a Ras-like protein, component of the mitotic exit network (MEN). Activation of TEM1 by LTE1 in the bud ultimately leads to activation of CDC15 followed by the release of CDC14 from the nucleolus, which then inactivates cyclin-dependent kinases (CDKs) activity by several mechanism. Required for TEM1 localization to the bud cortex during mitotic exit. Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis., [UniProtKB]; Involved in proprotein-processing like proalpha factor-processing in the secretory pathway., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 101, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VPJ4", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005933 cellular bud", "go_biological_process": "GO:0051301 cell division;GO:0007265 Ras protein signal transduction;GO:0016192 vesicle-mediated transport;GO:0031536 positive regulation of exit from mitosis;GO:1902480 protein localization to mitotic spindle", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P07866-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07991-1", "uniprot_id": "OAT_YEAST", "mass": 46086.0, "length": 424, "protein_name": "Ornithine aminotransferase", "gene_name": "CAR2", "organism": "Yeast", "refseq_name": "ornithine-oxo-acid transaminase", "refseq_ac": "NP_013542", "gene_names_uniprotkb": "CAR2; CARGB; L9753.2", "gene_names_refseq": "CAR2", "protein_names_uniprotkb": "Ornithine aminotransferase; 2.6.1.13; OTAse; Ornithine--oxo-acid aminotransferase", "protein_names_refseq": "ornithine-oxo-acid transaminase", "tax_id": 559292, "disease": "gyrate atrophy (Disease Ontology:DOID:1415); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YLR438W); (R-SCE-8964539)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;22106047;23749301;24374639;2824201;3036506;33491328;9169871", "class_list": "", "function": "Catalyzes the transamination of ornithine into L-glutamate gamma-semialdehyde, the second step of arginine degradation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ72", "ec_number_list": "2.6.1.13", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004587 ornithine aminotransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006591 ornithine metabolic process;GO:0055129 L-proline biosynthetic process;GO:0010121 L-arginine catabolic process to proline via ornithine;GO:0019544 L-arginine catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07991-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08004-1", "uniprot_id": "CHS1_YEAST", "mass": 129871.0, "length": 1131, "protein_name": "Chitin synthase 1", "gene_name": "CHS1", "organism": "Yeast", "refseq_name": "chitin synthase CHS1", "refseq_ac": "NP_014207", "gene_names_uniprotkb": "CHS1; N1404", "gene_names_refseq": "CHS1; USA4", "protein_names_uniprotkb": "Chitin synthase 1; 2.4.1.16; Chitin-UDP acetyl-glucosaminyl transferase 1", "protein_names_refseq": "chitin synthase CHS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL192W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17287358;17330950;18407956;19779198;21126336;23749301;24374639;2523889;2941152;32597660;33481703;33491328;9169873", "class_list": "", "function": "Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (PubMed:2941152). Required for mitotic division septum formation during adverse conditions (PubMed:2523889)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Z5", "ec_number_list": "2.4.1.16", "go_molecular_function": "GO:0004100 chitin synthase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0030428 cell septum;GO:0045009 chitosome", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0006031 chitin biosynthetic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08004-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08018-1", "uniprot_id": "PBS2_YEAST", "mass": 72720.0, "length": 668, "protein_name": "MAP kinase kinase PBS2", "gene_name": "PBS2", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase kinase PBS2", "refseq_ac": "NP_012407", "gene_names_uniprotkb": "PBS2; HOG4; J0699; SFS4; SSK4", "gene_names_refseq": "HOG4; PBS2; SFS4; SSK4", "protein_names_uniprotkb": "MAP kinase kinase PBS2; 2.7.12.2; Polymyxin B resistance protein 2; Suppressor of fluoride sensitivity 4", "protein_names_refseq": "mitogen-activated protein kinase kinase PBS2", "tax_id": 559292, "disease": "RASopathy (Disease Ontology:DOID:0080690); cardiofaciocutaneous syndrome 3 (Disease Ontology:DOID:0111462); cardiofaciocutaneous syndrome 4 (Disease Ontology:DOID:0111463); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); melorheostosis (Disease Ontology:DOID:4253); renal cell carcinoma (Disease Ontology:DOID:4450); small intestine adenocarcinoma (Disease Ontology:DOID:4906); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (sce:YJL128C); (R-SCE-168638); (R-SCE-2559580); (R-SCE-2871796); (R-SCE-450302); (R-SCE-6811555)", "pathway_count": 6, "publication_count": 36, "publication_id_list": "10970855;11875433;14562095;14562106;14685261;1479360;15200958;15256499;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;23749301;24374639;27846849;3039511;30516470;32011004;32597660;33229814;33481703;33491328;38270553;7624781;7681220;7814365;8641269;8948101;9032256", "class_list": "", "function": "Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment (PubMed:10970855, PubMed:15256499, PubMed:7681220). Activates the MAP kinase HOG1 by concomitant phosphorylation at 'Thr-174' and 'Tyr-176' (PubMed:38270553, PubMed:7681220)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 24, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 24, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 24, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 40, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "D6VW57", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;2.7.1.68;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:0031416 NatB complex;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0007231 osmosensory signaling pathway;GO:0006468 protein phosphorylation;GO:0007015 actin filament organization;GO:0000165 MAPK cascade;GO:0046677 response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "P08018-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08067-1", "uniprot_id": "UCRI_YEAST", "mass": 23365.0, "length": 215, "protein_name": "Cytochrome b-c1 complex subunit Rieske, mitochondrial", "gene_name": "RIP1", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase catalytic subunit RIP1", "refseq_ac": "NP_010890", "gene_names_uniprotkb": "RIP1", "gene_names_refseq": "RIP1", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit Rieske, mitochondrial; 7.1.1.8; Complex III subunit 5; RISP; Rieske iron-sulfur protein; Ubiquinol-cytochrome c oxidoreductase iron-sulfur subunit", "protein_names_refseq": "ubiquinol--cytochrome-c reductase catalytic subunit RIP1", "tax_id": 559292, "disease": "mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YEL024W); (R-SCE-611105); (R-SCE-9865878); (R-SCE-9865881)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10764779;10775262;10873857;11880631;1657998;17322287;18390544;24374639;2538628;2645276;3036836;30598554;30598556;6309810;8206223;9169868", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster (PubMed:18390544). It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b (COB) to cytochrome c1 (CYT1) (Probable) (PubMed:1657998, PubMed:2538628)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLM4", "ec_number_list": "7.1.1.8;3.6.4.10;3.4.24.64;2.8.1.7;1.16.3.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P08067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08153-1", "uniprot_id": "SWI5_YEAST", "mass": 79775.0, "length": 709, "protein_name": "Transcriptional factor SWI5", "gene_name": "SWI5", "organism": "Yeast", "refseq_name": "DNA-binding transcription factor SWI5", "refseq_ac": "NP_010430", "gene_names_uniprotkb": "SWI5; YD8358.03C", "gene_names_refseq": "SWI5", "protein_names_uniprotkb": "Transcriptional factor SWI5", "protein_names_refseq": "DNA-binding transcription factor SWI5", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR146C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10692159;1453468;14562106;15665377;1652372;17287358;17322287;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;2831463;30516470;32597660;3284746;33481703;33491328;7615496;9169867;9774660", "class_list": "", "function": "Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 58, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSC9;E9P945", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000082 G1/S transition of mitotic cell cycle;GO:0010458 exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P08153-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08417-1", "uniprot_id": "FUMH_YEAST", "mass": 53152.0, "length": 488, "protein_name": "Fumarate hydratase, mitochondrial", "gene_name": "FUM1", "organism": "Yeast", "refseq_name": "fumarase FUM1", "refseq_ac": "NP_015061", "gene_names_uniprotkb": "FUM1", "gene_names_refseq": "FUM1", "protein_names_uniprotkb": "Fumarate hydratase, mitochondrial; 4.2.1.2; Fumarase", "protein_names_refseq": "fumarase FUM1", "tax_id": 559292, "disease": "fumarase deficiency (Disease Ontology:DOID:0111261); lung non-small cell carcinoma (Disease Ontology:DOID:3908); leiomyomatosis (Disease Ontology:DOID:5138)", "pathway": " (sce:YPL262W); (R-SCE-71403); (R-SCE-9837999)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11502169;11585823;14562106;1587456;17761666;20231875;24374639;3040736;33058874;33481703;33491328;9169875;9665847", "class_list": "", "function": "Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:11585823, PubMed:1587456, PubMed:20231875, PubMed:3040736). In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (PubMed:1587456, PubMed:20231875). In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate (PubMed:20231875)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3A8;Q08978", "ec_number_list": "3.5.3.1;7.1.2.2;2.3.3.1;4.2.1.2;3.6.4.10;4.98.1.1;4.2.1.3;1.2.4.2;1.1.1.37;1.2.4.1;3.4.21.53;2.3.1.41;1.2.1.4;1.2.1.5;6.1.1.5;2.3.3.10", "go_molecular_function": "GO:0004333 fumarate hydratase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006106 fumarate metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08425-1", "uniprot_id": "SYFM_YEAST", "mass": 54829.0, "length": 469, "protein_name": "Phenylalanine--tRNA ligase, mitochondrial", "gene_name": "MSF1", "organism": "Yeast", "refseq_name": "phenylalanine--tRNA ligase", "refseq_ac": "NP_015372", "gene_names_uniprotkb": "MSF1; YP9499.05", "gene_names_refseq": "MSF1", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase, mitochondrial; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase", "protein_names_refseq": "phenylalanine--tRNA ligase", "tax_id": 559292, "disease": "hereditary spastic paraplegia 77 (Disease Ontology:DOID:0110822); combined oxidative phosphorylation deficiency 14 (Disease Ontology:DOID:0111477); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202)", "pathway": " (sce:YPR047W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12748633;14562095;14562106;14576278;1924298;24374639;3029120;9169875", "class_list": "", "function": "Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W455;Q12410", "ec_number_list": "6.1.1.20", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004826 phenylalanine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006432 phenylalanyl-tRNA aminoacylation;GO:0070156 mitochondrial phenylalanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08425-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08432-1", "uniprot_id": "DCOR_YEAST", "mass": 52285.0, "length": 466, "protein_name": "Ornithine decarboxylase", "gene_name": "SPE1", "organism": "Yeast", "refseq_name": "ornithine decarboxylase SPE1", "refseq_ac": "NP_012737", "gene_names_uniprotkb": "SPE1; ORD1", "gene_names_refseq": "ORD1; SPE10; SPE1", "protein_names_uniprotkb": "Ornithine decarboxylase; 4.1.1.17; ODC", "protein_names_refseq": "ornithine decarboxylase SPE1", "tax_id": 559292, "disease": "atrichia with papular lesions (Disease Ontology:DOID:0060689); pneumocystosis (Disease Ontology:DOID:11339); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YKL184W); (R-SCE-351143); (R-SCE-351202)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "14562095;14562106;15538383;24374639;2669750;3038869;33491328;6754461;6795198;8154185;8196765", "class_list": "", "function": "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX16", "ec_number_list": "4.1.1.17", "go_molecular_function": "GO:0004586 ornithine decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009446 putrescine biosynthetic process;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:0015940 pantothenate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P08432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08458-1", "uniprot_id": "SPS1_YEAST", "mass": 55704.0, "length": 490, "protein_name": "Sporulation-specific protein 1", "gene_name": "SPS1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase SPS1", "refseq_ac": "NP_010811", "gene_names_uniprotkb": "SPS1; D9719.27", "gene_names_refseq": "SPS1", "protein_names_uniprotkb": "Sporulation-specific protein 1; 2.7.11.1", "protein_names_refseq": "putative serine/threonine protein kinase SPS1", "tax_id": 559292, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (sce:YDR523C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;20489023;24374639;3023934;7958886;9169867", "class_list": "", "function": "Serine/threonine protein kinase required for spore wall development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTE3", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005628 prospore membrane", "go_biological_process": "GO:1904750 negative regulation of protein localization to nucleolus;GO:0007165 signal transduction;GO:0051229 meiotic spindle disassembly;GO:1903024 positive regulation of ascospore-type prospore membrane formation;GO:0030437 ascospore formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08466-1", "uniprot_id": "NUC1_YEAST", "mass": 37210.0, "length": 329, "protein_name": "Mitochondrial nuclease", "gene_name": "NUC1", "organism": "Yeast", "refseq_name": "ribonuclease", "refseq_ac": "NP_012327", "gene_names_uniprotkb": "NUC1; HRE329; J0310", "gene_names_refseq": "NUC1", "protein_names_uniprotkb": "Mitochondrial nuclease; 3.1.30.-", "protein_names_refseq": "ribonuclease", "tax_id": 559292, "disease": "brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (sce:YJL208C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;14690591;24374639;2552292;2836792;7725802;7754713;8641269", "class_list": "", "function": "This enzyme has both RNase and DNase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVY6", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0004520 DNA endonuclease activity;GO:0004540 RNA nuclease activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006310 DNA recombination;GO:0051607 defense response to virus;GO:0006915 apoptotic process;GO:0006309 apoptotic DNA fragmentation;GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08466-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08518-1", "uniprot_id": "RPB2_YEAST", "mass": 138751.0, "length": 1224, "protein_name": "DNA-directed RNA polymerase II subunit RPB2", "gene_name": "RPB2", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase II core subunit RPB2", "refseq_ac": "NP_014794", "gene_names_uniprotkb": "RPB2; RPB150; RPO22", "gene_names_refseq": "RPB150; RPB2; RPO22; SIT2; SOH2", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB2; 2.7.7.6; B150; DNA-directed RNA polymerase II 140 kDa polypeptide; RNA polymerase II subunit 2", "protein_names_refseq": "DNA-directed RNA polymerase II core subunit RPB2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR151C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 16, "publication_count": 30, "publication_id_list": "11313498;11313499;11805306;12746495;12746498;12748053;12914699;14562106;14580350;14963322;15537538;15565157;15591044;15610738;16341226;16765890;17330950;18407956;19684113;19779198;21126336;2204624;23749301;24374639;30181345;33481703;33491328;3547406;9046089;9169874", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerases II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcription cycle, Pol II, general transcription factors and the Mediator complex assemble as the preinitiation complex (PIC) at the promoter. 11-15 base pairs of DNA surrounding the transcription start site are melted and the single-stranded DNA template strand of the promoter is positioned deeply within the central active site cleft of Pol II to form the open complex. After synthesis of about 30 bases of RNA, Pol II releases its contacts with the core promoter and the rest of the transcription machinery (promoter clearance) and enters the stage of transcription elongation in which it moves on the template as the transcript elongates. Pol II appears to oscillate between inactive and active conformations at each step of nucleotide addition. Pol II is composed of mobile elements that move relative to each other. The core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center. The clamp element (portions of RPB1, RPB2 and RPB3) is connected to the core through a set of flexible switches and moves to open and close the cleft. The cleft is surrounded by jaws: an upper jaw formed by portions of RBP1, RPB2 and RPB9, and a lower jaw. The jaws are thought to grab the incoming DNA template. The fork loop 1 (RPB2) interacts with the RNA-DNA hybrid, possibly stabilizing it., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2K8;Q12738;Q7Z9Y0", "ec_number_list": "2.7.7.6;2.7.11.23;5.6.2.3;3.1.-.-;2.7.7.7;3.1.11.-;2.7.11.22;2.3.2.27;2.1.1.56;3.1.3.16;3.6.4.-;2.3.1.48;3.4.19.12;5.2.1.8;5.6.2.4;2.7.7.50", "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0010494 cytoplasmic stress granule;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0001172 RNA-templated transcription;GO:0006354 DNA-templated transcription elongation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P08518-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08524-1", "uniprot_id": "ERG20_YEAST", "mass": 40483.0, "length": 352, "protein_name": "Farnesyl pyrophosphate synthase", "gene_name": "ERG20", "organism": "Yeast", "refseq_name": "bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase", "refseq_ac": "NP_012368", "gene_names_uniprotkb": "ERG20; BOT3; FDS1; FPP1; J0525", "gene_names_refseq": "BOT3; ERG20; FDS1; FPP1", "protein_names_uniprotkb": "Farnesyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.10; 2.5.1.1; Dimethylallyltranstransferase; FPP synthase; FPS; Farnesyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (sce:YJL167W); (R-SCE-9969896)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "22814378;23749301;24374639;2681213;3036507;32679672;33481703;33491328;8096487;8641269", "class_list": "", "function": "Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:8096487). ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:8096487). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW20;P15495", "ec_number_list": "2.5.1.1;2.5.1.10;2.5.1.29;2.5.1.-", "go_molecular_function": "GO:0004452 isopentenyl-diphosphate delta-isomerase activity;GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005773 vacuole", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0033384 geranyl diphosphate biosynthetic process;GO:0045337 farnesyl diphosphate biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08524-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08525-1", "uniprot_id": "QCR8_YEAST", "mass": 10975.0, "length": 94, "protein_name": "Cytochrome b-c1 complex subunit 8, mitochondrial", "gene_name": "QCR8", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase subunit 8", "refseq_ac": "NP_012369", "gene_names_uniprotkb": "QCR8; J0526", "gene_names_refseq": "COR5; QCR8", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 8, mitochondrial; Complex III subunit 8; Complex III subunit VII; Ubiquinol-cytochrome c oxidoreductase subunit 8; Ubiquinol-cytochrome c reductase complex 11 kDa protein; Ubiquinone-binding protein QP-C", "protein_names_refseq": "ubiquinol--cytochrome-c reductase subunit 8", "tax_id": 559292, "disease": "mitochondrial complex III deficiency nuclear type 4 (Disease Ontology:DOID:0080113)", "pathway": " (sce:YJL166W); (R-SCE-611105); (R-SCE-9837999); (R-SCE-9865878)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10764779;10775262;10873857;11880631;14562106;17322287;18390544;24374639;3036507;30598554;30598556;8394810;8641269", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW21", "ec_number_list": "", "go_molecular_function": "GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08536-1", "uniprot_id": "MET3_YEAST", "mass": 57725.0, "length": 511, "protein_name": "Sulfate adenylyltransferase", "gene_name": "MET3", "organism": "Yeast", "refseq_name": "sulfate adenylyltransferase", "refseq_ac": "NP_012543", "gene_names_uniprotkb": "MET3; J1436", "gene_names_refseq": "MET3", "protein_names_uniprotkb": "Sulfate adenylyltransferase; 2.7.7.4; ATP-sulfurylase; Methionine-requiring protein 3; SAT; Sulfate adenylate transferase", "protein_names_refseq": "sulfate adenylyltransferase", "tax_id": 559292, "disease": "spondyloepimetaphyseal dysplasia, Pakistani type (Disease Ontology:DOID:0050812)", "pathway": " (sce:YJR010W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11157739;14562095;14562106;14983089;15665377;17322287;1789010;18407956;20702584;22814378;24374639;33229814;3325778;33491328;8641269;9799240", "class_list": "", "function": "Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VWI5;Q66R66", "ec_number_list": "2.7.7.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0004781 sulfate adenylyltransferase (ATP) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000096 sulfur amino acid metabolic process;GO:0070814 hydrogen sulfide biosynthetic process;GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P08536-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08539-1", "uniprot_id": "GPA1_YEAST", "mass": 54076.0, "length": 472, "protein_name": "Guanine nucleotide-binding protein alpha-1 subunit", "gene_name": "GPA1", "organism": "Yeast", "refseq_name": "guanine nucleotide-binding protein subunit alpha", "refseq_ac": "NP_011868", "gene_names_uniprotkb": "GPA1; CDC70; DAC1; SCG1", "gene_names_refseq": "CDC70; DAC1; GPA1; SCG1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein alpha-1 subunit; GP1-alpha", "protein_names_refseq": "guanine nucleotide-binding protein subunit alpha", "tax_id": 559292, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); cardiomyopathy (Disease Ontology:DOID:0050700); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); developmental and epileptic encephalopathy 17 (Disease Ontology:DOID:0080450); traumatic brain injury (Disease Ontology:DOID:0081292); dystonia 25 (Disease Ontology:DOID:0090055); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108); achromatopsia 4 (Disease Ontology:DOID:0110010); congenital stationary night blindness 1G (Disease Ontology:DOID:0110714); congenital stationary night blindness autosomal dominant 3 (Disease Ontology:DOID:0110715); inflammatory bowel disease 12 (Disease Ontology:DOID:0110887); familial multiple nevi flammei (Disease Ontology:DOID:0111529); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); neurodevelopmental disorder with involuntary movements (Disease Ontology:DOID:0112276); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); color blindness (Disease Ontology:DOID:13399); achromatopsia (Disease Ontology:DOID:13911); McCune Albright syndrome (Disease Ontology:DOID:1858); lung non-small cell carcinoma (Disease Ontology:DOID:3908); dystonia (Disease Ontology:DOID:543); congestive heart failure (Disease Ontology:DOID:6000); night blindness (Disease Ontology:DOID:8499)", "pathway": " (sce:YHR005C); (R-SCE-2514859); (R-SCE-418594)", "pathway_count": 3, "publication_count": 57, "publication_id_list": "10356642;10705368;10712512;10866688;11394869;11955054;12029138;12080046;12556475;12960402;14536090;14562095;14562106;14767760;15197187;15519996;16467474;16839886;17322287;17330950;17563356;18407956;1848203;1900495;1936988;19779198;20702584;2105453;2107073;21126336;2117698;21177495;21521692;2161538;23749301;24374639;2494429;2548076;2644047;3031665;3113738;3136318;32597660;33481703;33491328;8091229;8231812;8415763;8417317;8702760;8756677;8887662;8942643;9488712;9537998;9604890;9786851", "class_list": "", "function": "Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that mediates mating pheromone signal transduction. Binding of alpha-factor or a-factor to its cognate transmembrane receptor STE2 and STE3, respectively, allows the receptor to serve as a guanine nucleotide exchange factor (GEF) on GPA1. The exchange of GDP for GTP on the G protein alpha subunit alters its interaction with the G protein beta subunit STE4, leading to dissociation of the G protein beta-gamma dimer STE4-STE18. The dissociated subunits activate downstream effectors to activate the mating response pathway and induce changes necessary to produce mating-competent cells. STE4-STE18 activate the downstream pheromone signaling MAP kinase cascade leading to expression of mating-specific genes, inducing cell cycle arrest in G1, promoting polarized cell growth to form mating projections (shmoos), and establishing the changes in plasma membrane, cell wall and nuclear envelope to permit cell-cell fusion (plasmogamy) and fusion of the two haploid nuclei (karyogamy). GPA1 transmits a signal that requires direct binding to the effector enzyme PI3K located at the endosome, promoting increased PI3 production. The intrinsic GTPase activity of GPA1 determines the duration of signaling, and is dramatically accelerated by the RGS protein SST2. In unstimulated cells, GDP-bound GPA1 sequesters the G protein beta-gamma subunit STE4-STE18, preventing it from activating the downstream effectors. Also down-regulates the signal by inhibiting the pheromone-induced accumulation of FUS3 in the nucleus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 30, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKU8", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006109 regulation of carbohydrate metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0000742 karyogamy involved in conjugation with cellular fusion;GO:0000743 nuclear migration involved in conjugation with cellular fusion;GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "P08539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08566-1", "uniprot_id": "ARO1_YEAST", "mass": 174755.0, "length": 1588, "protein_name": "Pentafunctional AROM polypeptide", "gene_name": "ARO1", "organism": "Yeast", "refseq_name": "pentafunctional protein ARO1p", "refseq_ac": "NP_010412", "gene_names_uniprotkb": "ARO1; AROM; YD9302.02", "gene_names_refseq": "ARO1", "protein_names_uniprotkb": "Pentafunctional AROM polypeptide; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS", "protein_names_refseq": "pentafunctional protein ARO1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR127W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;19779198;19795423;19823750;21126336;24374639;24909858;2825635;2848727;33481703;33491328;33502312;9169867", "class_list": "", "function": "The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSB3", "ec_number_list": "1.1.1.25;2.5.1.19;2.7.1.71;4.2.1.10;4.2.3.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003855 3-dehydroquinate dehydratase activity;GO:0003856 3-dehydroquinate synthase activity;GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008652 amino acid biosynthetic process;GO:0009073 aromatic amino acid family biosynthetic process;GO:0009423 chorismate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08566-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08638-1", "uniprot_id": "LEUR_YEAST", "mass": 100153.0, "length": 886, "protein_name": "Regulatory protein LEU3", "gene_name": "LEU3", "organism": "Yeast", "refseq_name": "leucine-responsive transcriptional regulator LEU3", "refseq_ac": "NP_013556", "gene_names_uniprotkb": "LEU3; L9324.1", "gene_names_refseq": "LEU3", "protein_names_uniprotkb": "Regulatory protein LEU3", "protein_names_refseq": "leucine-responsive transcriptional regulator LEU3", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR451W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;17467953;17563356;18407956;19779198;21126336;23749301;24374639;2823102;3299266;33481703;33491328;9169871", "class_list": "", "function": "Factor for control of RNA levels of a group of leucine-specific genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ85", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0009098 L-leucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08638-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08640-1", "uniprot_id": "FLO11_YEAST", "mass": 136111.0, "length": 1367, "protein_name": "Flocculation protein FLO11", "gene_name": "FLO11", "organism": "Yeast", "refseq_name": "Flo11p", "refseq_ac": "NP_012284", "gene_names_uniprotkb": "FLO11; MAL5; MUC1; S1; S2", "gene_names_refseq": "FLO11; MUC1; STA4", "protein_names_uniprotkb": "Flocculation protein FLO11; Flo11p; Flocculin-11; Mucin-like protein 1", "protein_names_refseq": "Flo11p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR019C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10383953;11027318;11157168;16043420;16086015;17921350;18001350;20619652;22129043;24374639;25960408;27547826;3106330;3141213;32286952;8710886;8955395;9169870", "class_list": "", "function": "Homophilic binding protein that enables kin discrimination in heterogeneous yeast populations by mediating homotypic cell-cell interactions during flocculation, a reversible and asexual process in which cells adhere to form aggregates (flocs) (PubMed:17921350, PubMed:22129043, PubMed:25960408, PubMed:27547826, PubMed:32286952). Plays a role in cell-substrate adhesion, haploid invasive growth, diploid pseudohyphae formation and biofilm (flor) development (PubMed:11027318, PubMed:11157168, PubMed:16043420, PubMed:17921350, PubMed:18001350, PubMed:20619652, PubMed:8710886, PubMed:8955395). Adhesive activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose (PubMed:16043420, PubMed:22129043)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 31, "predicted_n_glycosites": 2, "predicted_o_glycosites": 29, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 31, "binding_glycan_count": 0, "secondary_ac_list": "D6VVV0;P08068", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole;GO:0005935 cellular bud neck;GO:0098552 side of membrane", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0098609 cell-cell adhesion;GO:0043709 cell adhesion involved in single-species biofilm formation;GO:0090606 single-species surface biofilm formation;GO:0097656 cell-cell self recognition", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P08640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08678-1", "uniprot_id": "CYAA_YEAST", "mass": 227834.0, "length": 2026, "protein_name": "Adenylate cyclase", "gene_name": "CYR1", "organism": "Yeast", "refseq_name": "adenylate cyclase", "refseq_ac": "NP_012529", "gene_names_uniprotkb": "CYR1; CDC35; HSR1; J1401; SRA4", "gene_names_refseq": "CDC35; CYR1; FIL1; HSR1; SRA4; TSM0185", "protein_names_uniprotkb": "Adenylate cyclase; 4.6.1.1; ATP pyrophosphate-lyase; Adenylyl cyclase", "protein_names_refseq": "adenylate cyclase", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (sce:YJL005W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;1991451;20489023;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24909858;2934138;30516470;32597660;3327602;33481703;33491328;8641269", "class_list": "", "function": "Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 69, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWH0", "ec_number_list": "4.6.1.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0006171 cAMP biosynthetic process;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P08678-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08679-1", "uniprot_id": "CISY2_YEAST", "mass": 51413.0, "length": 460, "protein_name": "Citrate synthase, peroxisomal", "gene_name": "CIT2", "organism": "Yeast", "refseq_name": "citrate (Si)-synthase CIT2", "refseq_ac": "NP_009931", "gene_names_uniprotkb": "CIT2; YCR043; YCR5C", "gene_names_refseq": "CIT2", "protein_names_uniprotkb": "Citrate synthase, peroxisomal; 2.3.3.16", "protein_names_refseq": "citrate (Si)-synthase CIT2", "tax_id": 559292, "disease": "limb ischemia (Disease Ontology:DOID:0050852); left ventricular failure (Disease Ontology:DOID:0051064); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); bipolar disorder (Disease Ontology:DOID:3312); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YCR005C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12872131;14562106;1574125;1580102;17322287;19779198;1986232;2181273;22106047;22814378;24374639;25982115;3023912;33481703;33491328;3540614", "class_list": "", "function": "Peroxisomal citrate synthase involved in the citrate homeostasis (PubMed:25982115, PubMed:3023912). Catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate (PubMed:25982115, PubMed:3023912). Citrate synthase is the rate-limiting enzyme of the tricarboxylic acid (TCA) cycle (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR15", "ec_number_list": "2.3.3.1;2.3.3.16", "go_molecular_function": "GO:0042802 identical protein binding;GO:0036440 citrate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P08679-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08964-1", "uniprot_id": "MYO1_YEAST", "mass": 223636.0, "length": 1928, "protein_name": "Myosin-1", "gene_name": "MYO1", "organism": "Yeast", "refseq_name": "myosin 1", "refseq_ac": "NP_011888", "gene_names_uniprotkb": "MYO1", "gene_names_refseq": "MYO1", "protein_names_uniprotkb": "Myosin-1; Type II myosin", "protein_names_refseq": "myosin 1", "tax_id": 559292, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); metabolic acidosis (Disease Ontology:DOID:0050758); stroke (Disease Ontology:DOID:0051061); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); MYH-9 related disease (Disease Ontology:DOID:0060651); distal myopathy 1 (Disease Ontology:DOID:0070197); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A (Disease Ontology:DOID:0081321); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B (Disease Ontology:DOID:0081322); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); Alport syndrome 3A (Disease Ontology:DOID:0110032); atrial heart septal defect 3 (Disease Ontology:DOID:0110108); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); hypertrophic cardiomyopathy 14 (Disease Ontology:DOID:0110320); dilated cardiomyopathy 1EE (Disease Ontology:DOID:0110453); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant nonsyndromic deafness 17 (Disease Ontology:DOID:0110548); autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); autosomal recessive hyaline body myopathy (Disease Ontology:DOID:0111268); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B (Disease Ontology:DOID:0111599); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 7 (Disease Ontology:DOID:0111603); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); distal myopathy (Disease Ontology:DOID:11720); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); patent ductus arteriosus (Disease Ontology:DOID:13832); sick sinus syndrome (Disease Ontology:DOID:13884); thoracic aortic aneurysm (Disease Ontology:DOID:14004); disease of cellular proliferation (Disease Ontology:DOID:14566); hypothyroidism (Disease Ontology:DOID:1459); thrombocytopenia (Disease Ontology:DOID:1588); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); muscular dystrophy (Disease Ontology:DOID:9884); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (sce:YHR023W); (R-SCE-5627123)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;17287358;17330950;17563356;18407956;19779198;19795423;19823750;21126336;2263482;23749301;24374639;32597660;3322809;33481703;33491328;8091229", "class_list": "", "function": "Required for cell division., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKX0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0032027 myosin light chain binding;GO:0000146 microfilament motor activity;GO:0032033 myosin II light chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0016460 myosin II complex;GO:0000131 incipient cellular bud site;GO:0000142 cellular bud neck contractile ring", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0000281 mitotic cytokinesis;GO:1904498 protein localization to mitotic actomyosin contractile ring;GO:1903475 mitotic actomyosin contractile ring assembly;GO:0031671 primary cell septum biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P08964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09032-1", "uniprot_id": "EI2BG_YEAST", "mass": 65700.0, "length": 578, "protein_name": "Translation initiation factor eIF2B subunit gamma", "gene_name": "GCD1", "organism": "Yeast", "refseq_name": "translation initiation factor eIF2B subunit gamma", "refseq_ac": "NP_014903", "gene_names_uniprotkb": "GCD1; TIF223; TRA3", "gene_names_refseq": "GCD1; TRA3", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit gamma; GCD complex subunit GCD1; Guanine nucleotide exchange factor subunit GCD1; eIF2B GDP-GTP exchange factor subunit gamma", "protein_names_refseq": "translation initiation factor eIF2B subunit gamma", "tax_id": 559292, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 3 (Disease Ontology:DOID:0070372)", "pathway": " (sce:YOR260W); (R-SCE-72731)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "14562106;15665377;17287358;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;23775072;24374639;3050897;30516470;32027465;32597660;33481703;33491328;8506384;9153759;9169874;9472020", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD1 stabilizes the interaction between eIF2 and GCD6 and stimulates the catalytic activity in vitro., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2W1;Q08721", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006446 regulation of translational initiation;GO:1903574 negative regulation of cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P09032-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09064-1", "uniprot_id": "IF2B_YEAST", "mass": 31574.0, "length": 285, "protein_name": "Eukaryotic translation initiation factor 2 subunit beta", "gene_name": "SUI3", "organism": "Yeast", "refseq_name": "translation initiation factor eIF2 subunit beta", "refseq_ac": "NP_015087", "gene_names_uniprotkb": "SUI3; TIF212", "gene_names_refseq": "SUI3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit beta; eIF2-beta", "protein_names_refseq": "translation initiation factor eIF2 subunit beta", "tax_id": 559292, "disease": "leukodystrophy (Disease Ontology:DOID:10579)", "pathway": " (sce:YPL237W); (R-SCE-156827); (R-SCE-382556); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702); (R-SCE-72731); (R-SCE-9840373)", "pathway_count": 8, "publication_count": 29, "publication_id_list": "10075937;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;23775072;24374639;27821475;30516470;30517694;3136928;32027465;32597660;33481703;33491328;33743194;34965436;35031321;37507029;9169875", "class_list": "", "function": "Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3D3;Q6B200", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005840 ribosome;GO:0016282 eukaryotic 43S preinitiation complex;GO:0043614 multi-eIF complex;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P09064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09119-1", "uniprot_id": "CDC6_YEAST", "mass": 58037.0, "length": 513, "protein_name": "DNA replication factor CDC6", "gene_name": "CDC6", "organism": "Yeast", "refseq_name": "AAA family ATPase CDC6", "refseq_ac": "NP_012341", "gene_names_uniprotkb": "CDC6; J0347", "gene_names_refseq": "CDC6", "protein_names_uniprotkb": "DNA replication factor CDC6; Cell division control protein 6", "protein_names_refseq": "AAA family ATPase CDC6", "tax_id": 559292, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 5 (Disease Ontology:DOID:0080516)", "pathway": " (sce:YJL194W); (R-SCE-176187); (R-SCE-68689); (R-SCE-68962); (R-SCE-69017)", "pathway_count": 5, "publication_count": 30, "publication_id_list": "10075735;10512865;10734126;11532947;11572976;1600944;17130241;17267692;19779198;2246267;23129771;23236290;23603117;23749301;24374639;25995377;2656692;3062576;33481703;33491328;35142288;7641697;7754713;8538771;8641269;8892760;8978693;9099949;9312054;9892652", "class_list": "", "function": "Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVZ7", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0031261 DNA replication preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P09119-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09201-1", "uniprot_id": "F16P_YEAST", "mass": 38263.0, "length": 348, "protein_name": "Fructose-1,6-bisphosphatase", "gene_name": "FBP1", "organism": "Yeast", "refseq_name": "fructose 1,6-bisphosphate 1-phosphatase", "refseq_ac": "NP_013481", "gene_names_uniprotkb": "FBP1; L8039.18", "gene_names_refseq": "ACN8; FBP1", "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase; FBPase", "protein_names_refseq": "fructose 1,6-bisphosphate 1-phosphatase", "tax_id": 559292, "disease": "fructose-1,6-bisphosphatase deficiency (Disease Ontology:DOID:5204)", "pathway": " (sce:YLR377C); (R-SCE-70263)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "12686616;14562106;17322287;18508925;19779198;21177495;22645139;24374639;28126757;2834361;2834362;2841162;3005313;3008716;3038868;33491328;9169871;9737955", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ13", "ec_number_list": "3.1.3.11", "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042597 periplasmic space", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P09201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09232-1", "uniprot_id": "PRTB_YEAST", "mass": 69621.0, "length": 635, "protein_name": "Cerevisin", "gene_name": "PRB1", "organism": "Yeast", "refseq_name": "proteinase B", "refseq_ac": "NP_010854", "gene_names_uniprotkb": "PRB1", "gene_names_refseq": "CVT1; PRB1", "protein_names_uniprotkb": "Cerevisin; 3.4.21.48; PrB; Proteinase YSCB; Vacuolar protease B", "protein_names_refseq": "proteinase B", "tax_id": 559292, "disease": "familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390)", "pathway": " (sce:YEL060C); (R-SCE-8866427); (R-SCE-8964038)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "12923060;14562106;1744078;17563356;18407956;19779198;19795423;19823750;21177495;23749301;2407604;24374639;2645294;32597660;3325823;33481703;33491328;34965436;6764902;7021321;9169868", "class_list": "", "function": "Vacuolar proteinase B involved in protein degradation in the vacuole. Among other substrates, acts on carboxypeptidase Y (cpY/PRC1) to activate it by processing its Pro-peptide. Required for meiosis and spore formation, and for optimal survival in stationary phase., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ0", "ec_number_list": "3.4.21.48;3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0000324 fungal-type vacuole;GO:0000328 fungal-type vacuole lumen", "go_biological_process": "GO:0006508 proteolysis;GO:0007039 protein catabolic process in the vacuole;GO:0000425 pexophagy;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P09232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09440-1", "uniprot_id": "C1TM_YEAST", "mass": 106217.0, "length": 975, "protein_name": "C-1-tetrahydrofolate synthase, mitochondrial", "gene_name": "MIS1", "organism": "Yeast", "refseq_name": "trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1", "refseq_ac": "NP_009640", "gene_names_uniprotkb": "MIS1; YBR0751", "gene_names_refseq": "MIS1", "protein_names_uniprotkb": "C-1-tetrahydrofolate synthase, mitochondrial; C1-THF synthase", "protein_names_refseq": "trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1", "tax_id": 559292, "disease": "spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); developmental cardiac valvular defect (Disease Ontology:DOID:0080633); Down syndrome (Disease Ontology:DOID:14250); tetralogy of Fallot (Disease Ontology:DOID:6419); cleft palate (Disease Ontology:DOID:674); abdominal aortic aneurysm (Disease Ontology:DOID:7693); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (sce:YBR084W); (R-SCE-196757)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14562095;14562106;14576278;18407956;19779198;19795423;19823750;24374639;2836393;33481703;33491328;3528153;7813418", "class_list": "", "function": "Mitochondrial isozyme of C-1-tetrahydrofolate synthase. The trifunctional enzyme catalyzes the interconversion of the one-carbon derivatives of tetrahydrofolate (THF) between different oxidation states by the enzymatic activities 10-formyltetrahydrofolate synthetase, 5,lO-methenyltetrahydrofolate cyclohydrolase, and 5,lO-methylenetetrahydrofolate dehydrogenase., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ83", "ec_number_list": "6.3.4.3;1.5.1.5;3.5.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:0035999 tetrahydrofolate interconversion;GO:0046656 folic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P09440-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09547-1", "uniprot_id": "SWI1_YEAST", "mass": 147938.0, "length": 1314, "protein_name": "SWI/SNF chromatin-remodeling complex subunit SWI1", "gene_name": "SWI1", "organism": "Yeast", "refseq_name": "Swi1p", "refseq_ac": "NP_015309", "gene_names_uniprotkb": "SWI1; ADR6; GAM3; LPA1", "gene_names_refseq": "ADR6; GAM3; LPA1; SWI1", "protein_names_uniprotkb": "SWI/SNF chromatin-remodeling complex subunit SWI1; Regulatory protein GAM3; SWI/SNF complex subunit SWI1; Transcription regulatory protein ADR6; Transcription regulatory protein SWI1", "protein_names_refseq": "Swi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL016W); (R-SCE-3214815)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "11727987;12524530;1339306;14562106;18362884;18407956;19779198;19795423;19823750;20679490;21126336;21379326;21670156;23749301;24374639;3143101;33229814;33481703;33491328;9169875", "class_list": "", "function": "Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Z6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P09547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09620-1", "uniprot_id": "KEX1_YEAST", "mass": 82245.0, "length": 729, "protein_name": "Pheromone-processing carboxypeptidase KEX1", "gene_name": "KEX1", "organism": "Yeast", "refseq_name": "serine-type carboxypeptidase", "refseq_ac": "NP_011312", "gene_names_uniprotkb": "KEX1", "gene_names_refseq": "KEX1", "protein_names_uniprotkb": "Pheromone-processing carboxypeptidase KEX1; 3.4.16.6; Carboxypeptidase D; Killer expression defective protein 1", "protein_names_refseq": "serine-type carboxypeptidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL203C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10972812;11988505;14562095;14562106;1469044;17210951;17287358;18474590;19779198;24374639;2668738;3301004;3301840;3305079;33481703;33491328;4364866;773743;8416959;8745419;9169869;9220988", "class_list": "", "function": "Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from the precursors of K1, K2 and K28 killer toxins and a-factor (mating pheromone). Involved in the programmed cell death caused by defective N-glycosylation and also contributes to the active cell death program induced by acetic acid stress or during chronological aging. Promotes cell fusion by proteolytically processing substrates that act in parallel to PRM1 as an alternative fusion machine, as cell wall components, or both., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VTV1", "ec_number_list": "", "go_molecular_function": "GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "GO:0005802 trans-Golgi network;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P09620-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09624-1", "uniprot_id": "DLDH_YEAST", "mass": 54010.0, "length": 499, "protein_name": "Dihydrolipoyl dehydrogenase, mitochondrial", "gene_name": "LPD1", "organism": "Yeast", "refseq_name": "dihydrolipoyl dehydrogenase", "refseq_ac": "NP_116635", "gene_names_uniprotkb": "LPD1; DHLP1", "gene_names_refseq": "HPD1; LPD1", "protein_names_uniprotkb": "Dihydrolipoyl dehydrogenase, mitochondrial; 1.8.1.4; 2-oxoglutarate dehydrogenase complex component E3; Alpha-ketoglutarate dehydrogenase complex subunit E3; DLD; Dihydrolipoamide dehydrogenase; Dihydrolipoamide:NAD(+) oxidoreductase; GDC subunit L; Glycine decarboxylase complex subunit L; Lipoamide dehydrogenase component of pyruvate dehydrogenase complex; OGDC-E3; OGDHC subunit E3; PDC subunit E3; PDH complex subunit E3; Pyruvate dehydrogenase complex E3 component; alpha-KGDHC subunit E3", "protein_names_refseq": "dihydrolipoyl dehydrogenase", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); dihydrolipoamide dehydrogenase deficiency (Disease Ontology:DOID:0061204)", "pathway": " (sce:YFL018C); (R-SCE-6783984); (R-SCE-9853506); (R-SCE-9861559)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "12756305;14562106;2072900;24374639;25165143;2821168;3058861;32597660;3279419;33491328;7498764;7670463;9538259", "class_list": "", "function": "Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and the 2-oxoglutarate dehydrogenase complex, which catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:2821168). Also acts as a component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine (PubMed:7498764)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTL1", "ec_number_list": "1.8.1.4;2.3.1.12;1.2.4.1;2.3.1.61;1.2.4.2", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004375 glycine dehydrogenase (decarboxylating) activity;GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity;GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0005960 glycine cleavage complex;GO:0045252 oxoglutarate dehydrogenase complex;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0006574 L-valine catabolic process;GO:0006552 L-leucine catabolic process;GO:0006546 glycine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P09624-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09733-1", "uniprot_id": "TBA1_YEAST", "mass": 49800.0, "length": 447, "protein_name": "Tubulin alpha-1 chain", "gene_name": "TUB1", "organism": "Yeast", "refseq_name": "alpha-tubulin TUB1", "refseq_ac": "NP_013625", "gene_names_uniprotkb": "TUB1", "gene_names_refseq": "TUB1", "protein_names_uniprotkb": "Tubulin alpha-1 chain; 3.6.5.-", "protein_names_refseq": "alpha-tubulin TUB1", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); amyotrophic lateral sclerosis type 22 (Disease Ontology:DOID:0060355); autosomal dominant isolated macrothrombocytopenia 2 (Disease Ontology:DOID:0060995); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234); keratoconus (Disease Ontology:DOID:10126); microcephaly (Disease Ontology:DOID:10907); Down syndrome (Disease Ontology:DOID:14250); thrombocytopenia (Disease Ontology:DOID:1588); congenital nervous system abnormality (Disease Ontology:DOID:2490)", "pathway": " (sce:YML085C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11739794;14562106;17563356;19779198;22031224;24374639;3025610;33491328;9169872", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:11739794). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0J8", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0034399 nuclear periphery", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0000070 mitotic sister chromatid segregation;GO:0030473 nuclear migration along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P09733-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09734-1", "uniprot_id": "TBA3_YEAST", "mass": 49694.0, "length": 445, "protein_name": "Tubulin alpha-3 chain", "gene_name": "TUB3", "organism": "Yeast", "refseq_name": "alpha-tubulin TUB3", "refseq_ac": "NP_013582", "gene_names_uniprotkb": "TUB3; YM7056.02C", "gene_names_refseq": "TUB3", "protein_names_uniprotkb": "Tubulin alpha-3 chain; 3.6.5.-", "protein_names_refseq": "alpha-tubulin TUB3", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); osteoblastoma (Disease Ontology:DOID:0060098); amyotrophic lateral sclerosis type 22 (Disease Ontology:DOID:0060355); lissencephaly 3 (Disease Ontology:DOID:0112232); keratoconus (Disease Ontology:DOID:10126); Alzheimer's disease (Disease Ontology:DOID:10652); microcephaly (Disease Ontology:DOID:10907); leukemia (Disease Ontology:DOID:1240); Down syndrome (Disease Ontology:DOID:14250); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); congenital nervous system abnormality (Disease Ontology:DOID:2490); lung carcinoma (Disease Ontology:DOID:3905)", "pathway": " (sce:YML124C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11266443;14562106;14690591;2038328;24374639;3025610;33481703;33491328;9169872", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0G1", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0045298 tubulin complex", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0000070 mitotic sister chromatid segregation;GO:0030473 nuclear migration along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P09734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09798-1", "uniprot_id": "CDC16_YEAST", "mass": 94992.0, "length": 840, "protein_name": "Anaphase-promoting complex subunit CDC16", "gene_name": "CDC16", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit CDC16", "refseq_ac": "NP_012903", "gene_names_uniprotkb": "CDC16", "gene_names_refseq": "CDC16", "protein_names_uniprotkb": "Anaphase-promoting complex subunit CDC16; Cell division control protein 16", "protein_names_refseq": "anaphase promoting complex subunit CDC16", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL022C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10871279;11114178;12928868;14562095;14562106;15060174;18407956;19779198;23749301;2404612;24374639;2823230;32597660;33229814;33481703;33491328;7925276;8196765;9660930", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VXR3", "ec_number_list": "", "go_molecular_function": "GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P09798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09880-1", "uniprot_id": "TRNL_YEAST", "mass": 95337.0, "length": 827, "protein_name": "tRNA ligase", "gene_name": "TRL1", "organism": "Yeast", "refseq_name": "tRNA ligase", "refseq_ac": "NP_012448", "gene_names_uniprotkb": "TRL1; J0927; RLG1", "gene_names_refseq": "LIG1; RLG1; TRL1", "protein_names_uniprotkb": "tRNA ligase; 6.5.1.3", "protein_names_refseq": "tRNA ligase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL087C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;2207062;24374639;3277966;33491328;7483841;8641269", "class_list": "", "function": "One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW97", "ec_number_list": "", "go_molecular_function": "GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0005524 ATP binding;GO:0004519 endonuclease activity;GO:0003972 RNA ligase (ATP) activity;GO:0051730 GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0036498 IRE1-mediated unfolded protein response;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0032056 positive regulation of translation in response to stress;GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay;GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09938-1", "uniprot_id": "RIR2_YEAST", "mass": 46147.0, "length": 399, "protein_name": "Ribonucleoside-diphosphate reductase small chain 1", "gene_name": "RNR2", "organism": "Yeast", "refseq_name": "ribonucleotide-diphosphate reductase subunit RNR2", "refseq_ac": "NP_012508", "gene_names_uniprotkb": "RNR2; CRT6; J1271", "gene_names_refseq": "CRT6; RNR2", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase small chain 1; 1.17.4.1; Ribonucleotide reductase R2 subunit 1; Ribonucleotide reductase small subunit 1", "protein_names_refseq": "ribonucleotide-diphosphate reductase subunit RNR2", "tax_id": 559292, "disease": "mitochondrial DNA depletion syndrome 8a (Disease Ontology:DOID:0080127); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518); urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic cancer (Disease Ontology:DOID:1793); endometrial adenocarcinoma (Disease Ontology:DOID:2870); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YJL026W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10535923;10716984;11526233;12732713;14562106;15196016;15665377;17287358;17330950;17563356;18407956;18851834;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;29263158;32597660;3313004;3316984;33481703;33491328;8641269", "class_list": "", "function": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWF6", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0008198 ferrous iron binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005971 ribonucleoside-diphosphate reductase complex", "go_biological_process": "GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P09938-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09950-1", "uniprot_id": "HEM1_YEAST", "mass": 59362.0, "length": 548, "protein_name": "5-aminolevulinate synthase, mitochondrial", "gene_name": "HEM1", "organism": "Yeast", "refseq_name": "5-aminolevulinate synthase", "refseq_ac": "NP_010518", "gene_names_uniprotkb": "HEM1; CYD1; YD9934.16", "gene_names_refseq": "CYD1; HEM1; OLE3", "protein_names_uniprotkb": "5-aminolevulinate synthase, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase", "protein_names_refseq": "5-aminolevulinate synthase", "tax_id": 559292, "disease": "sideroblastic anemia 1 (Disease Ontology:DOID:0060063); porphyria (Disease Ontology:DOID:13268); erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); hemolytic anemia (Disease Ontology:DOID:583); pulmonary hypertension (Disease Ontology:DOID:6432); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (sce:YDR232W); (R-SCE-189451)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;17322287;24374639;25957689;3023841;3321068;33491328;3516694;6381051;9169867", "class_list": "", "function": "Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSL3;E9P946", "ec_number_list": "2.3.1.37", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1902117 positive regulation of organelle assembly;GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P09950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09959-1", "uniprot_id": "SWI6_YEAST", "mass": 90560.0, "length": 803, "protein_name": "Regulatory protein SWI6", "gene_name": "SWI6", "organism": "Yeast", "refseq_name": "transcriptional regulator SWI6", "refseq_ac": "NP_013283", "gene_names_uniprotkb": "SWI6; L9470.8", "gene_names_refseq": "PSL8; SDS11; SWI6", "protein_names_uniprotkb": "Regulatory protein SWI6; Cell-cycle box factor subunit SWI6; MBF subunit P90; Trans-acting activator of HO endonuclease gene", "protein_names_refseq": "transcriptional regulator SWI6", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR182W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10048928;10409718;12697814;12724400;14562106;14993267;14998990;1608451;17287358;17330950;17563356;18160399;18407956;19779198;19795423;19823750;20219973;20587033;20702584;21126336;22218487;22814378;23749301;24374639;2821408;30516470;32597660;33481703;33491328;8590795;9169871", "class_list": "", "function": "Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYI6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030907 MBF transcription complex;GO:0033309 SBF transcription complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0034605 cellular response to heat;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P09959-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0T4-1", "uniprot_id": "RS25B_YEAST", "mass": 12009.0, "length": 108, "protein_name": "Small ribosomal subunit protein eS25B", "gene_name": "RPS25B", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS25 RPS25B", "refseq_ac": "NP_013437", "gene_names_uniprotkb": "RPS25B; L8300.10; RPS31B; RPS31", "gene_names_refseq": "RPS25B", "protein_names_uniprotkb": "Small ribosomal subunit protein eS25B; 40S ribosomal protein S25-B; RP45; S31; YS23", "protein_names_refseq": "40S ribosomal protein eS25 RPS25B", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR333C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 16, "publication_id_list": "14562095;14562106;17244705;17287358;17322287;18782943;19795423;19823750;20481588;22096102;24374639;24524803;32597660;33491328;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBM7;D6VYX4;P05758;P07282", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006451 translational readthrough", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P0C0T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0V8-1", "uniprot_id": "RS21A_YEAST", "mass": 9746.0, "length": 87, "protein_name": "Small ribosomal subunit protein eS21A", "gene_name": "RPS21A", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS21 RPS21A", "refseq_ac": "NP_012983", "gene_names_uniprotkb": "RPS21A; RPS25A; RPS25; RPS26A", "gene_names_refseq": "RPS21A; RPS25", "protein_names_uniprotkb": "Small ribosomal subunit protein eS21A; 40S ribosomal protein S21-A; S26; YS25", "protein_names_refseq": "40S ribosomal protein eS21 RPS21A", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR057W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10601260;14562095;14562106;14627813;15665377;22096102;22218487;24374639;24524803;2899871;32597660;3910104;8196765;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (PubMed:14627813)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB8;P05760", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412 translation;GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P0C0V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0X0-1", "uniprot_id": "RS28B_YEAST", "mass": 7565.0, "length": 67, "protein_name": "Small ribosomal subunit protein eS28B", "gene_name": "RPS28B", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS28 RPS28B", "refseq_ac": "NP_013366", "gene_names_uniprotkb": "RPS28B; L8479.5; RPS33B", "gene_names_refseq": "RPS28B; RPS33B", "protein_names_uniprotkb": "Small ribosomal subunit protein eS28B; 40S ribosomal protein S28-B; S33; YS27", "protein_names_refseq": "40S ribosomal protein eS28 RPS28B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 15 with mandibulofacial dysostosis (Disease Ontology:DOID:0111894)", "pathway": " (sce:YLR264W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 16, "publication_id_list": "10601260;14562095;14562106;17563356;18407956;21177495;22096102;22218487;22814378;23749301;24374639;24524803;33481703;33491328;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYR1;P02380", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0002181 cytoplasmic translation;GO:0030490 maturation of SSU-rRNA;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P0C0X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2I2-1", "uniprot_id": "YD14B_YEAST", "mass": 198527.0, "length": 1755, "protein_name": "Transposon Ty1-DR5 Gag-Pol polyprotein", "gene_name": "TY1B-DR5", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058150", "gene_names_uniprotkb": "TY1B-DR5; D9740.1; YDRWTy1-4 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-DR5 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR316W-B)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;16093680;17287358;24374639;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSU6", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C2I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2I3-1", "uniprot_id": "YD15B_YEAST", "mass": 198659.0, "length": 1755, "protein_name": "Transposon Ty1-DR6 Gag-Pol polyprotein", "gene_name": "TY1B-DR6", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058152", "gene_names_uniprotkb": "TY1B-DR6; D9481.12; YDRWTy1-5 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-DR6 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR365W-B)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;16093680;17287358;24374639;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSZ5", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C2I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2I5-1", "uniprot_id": "YL12B_YEAST", "mass": 198545.0, "length": 1755, "protein_name": "Transposon Ty1-LR2 Gag-Pol polyprotein", "gene_name": "TY1B-LR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058169", "gene_names_uniprotkb": "TY1B-LR2; L9632.7; YLRCTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-LR2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR157C-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169871;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VYF8", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C2I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2I6-1", "uniprot_id": "YL13B_YEAST", "mass": 198405.0, "length": 1755, "protein_name": "Transposon Ty1-LR3 Gag-Pol polyprotein", "gene_name": "TY1B-LR3", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058171", "gene_names_uniprotkb": "TY1B-LR3; L8083.11; YLRWTy1-3 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-LR3 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR227W-B)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16093660;16093680;17330950;17563356;18407956;19779198;21177495;24374639;9169871;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VYM8", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0C2I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2I9-1", "uniprot_id": "YP12B_YEAST", "mass": 198568.0, "length": 1755, "protein_name": "Transposon Ty1-PR1 Gag-Pol polyprotein", "gene_name": "TY1B-PR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058191", "gene_names_uniprotkb": "TY1B-PR1; P9659.6c; YPRCTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-PR1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR137C-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169875;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W4D4", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C2I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2J0-1", "uniprot_id": "YP13B_YEAST", "mass": 198639.0, "length": 1756, "protein_name": "Transposon Ty1-PR2 Gag-Pol polyprotein", "gene_name": "TY1B-PR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058193", "gene_names_uniprotkb": "TY1B-PR2; P9584.3c; YPRWTy1-3 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-PR2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR158W-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169875;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W4F5", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C2J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2J1-1", "uniprot_id": "YP14B_YEAST", "mass": 198374.0, "length": 1755, "protein_name": "Transposon Ty1-PR3 Gag-Pol polyprotein", "gene_name": "TY1B-PR3", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058195", "gene_names_uniprotkb": "TY1B-PR3; P9584.3; YPRCTy1-4 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-PR3 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR158C-D)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;16093680;18407956;24374639;9169875;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W4F7", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C2J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2J3-1", "uniprot_id": "YL21B_YEAST", "mass": 202122.0, "length": 1770, "protein_name": "Transposon Ty2-LR1 Gag-Pol polyprotein", "gene_name": "TY2B-LR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058174", "gene_names_uniprotkb": "TY2B-LR1; L9931.7b; YLRWTy2-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty2-LR1 Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR410W-B)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16093660;24374639;9169871;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ45", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0C2J3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2J7-1", "uniprot_id": "YH41B_YEAST", "mass": 207970.0, "length": 1802, "protein_name": "Transposon Ty4-H Gag-Pol polyprotein", "gene_name": "TY4B-H", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058133", "gene_names_uniprotkb": "TY4B-H; YHL008W-A; YHLWTy4-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty4-H Gag-Pol polyprotein; TY4A-TY4B; Transposon Ty4 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL009W-B)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16093660;24374639;8091229;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DKQ5", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0C2J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C5R9-1", "uniprot_id": "RNK_YEAST", "mass": 9361.0, "length": 85, "protein_name": "V-type proton ATPase subunit f", "gene_name": "", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_001106949", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "V-type proton ATPase subunit f; V-ATPase subunit f", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR170W-B)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12775844;12844361;24374639;26928762;27776355;29526695;29897761;30910982;9169875", "class_list": "", "function": "Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:29526695). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:29526695)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4H1", "ec_number_list": "", "go_molecular_function": "GO:0004521 RNA endonuclease activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0C5R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CD91-1", "uniprot_id": "AQY1_YEAST", "mass": 32713.0, "length": 305, "protein_name": "Aquaporin-1", "gene_name": "AQY1", "organism": "Yeast", "refseq_name": "Aqy1p", "refseq_ac": "NP_015518", "gene_names_uniprotkb": "AQY1; AQY1-2; P9677.5", "gene_names_refseq": "AQY1", "protein_names_uniprotkb": "Aquaporin-1", "protein_names_refseq": "Aqy1p", "tax_id": 559292, "disease": "Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); transverse myelitis (Disease Ontology:DOID:0080743); nephrogenic diabetes insipidus type 2 (Disease Ontology:DOID:0081061); cataract 15 multiple types (Disease Ontology:DOID:0110251); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Bothnian type palmoplantar keratoderma (Disease Ontology:DOID:0111707); dry eye syndrome (Disease Ontology:DOID:10140); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); uveitis (Disease Ontology:DOID:13141); blindness (Disease Ontology:DOID:1432); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); diabetic ketoacidosis (Disease Ontology:DOID:1837); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); thymoma (Disease Ontology:DOID:3275); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679); central pontine myelinolysis (Disease Ontology:DOID:636); cataract (Disease Ontology:DOID:83); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); diabetes mellitus (Disease Ontology:DOID:9351); diabetes insipidus (Disease Ontology:DOID:9409); intracranial hypertension (Disease Ontology:DOID:9428); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (sce:YPR192W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10092523;10870101;12524434;16847258;17322287;24374639;33491328;9169875;9765289", "class_list": "", "function": "Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance (By similarity). Is non-functional in most laboratory strains., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4J2;O74680;P53386", "ec_number_list": "", "go_molecular_function": "GO:0015250 water channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006833 water transport;GO:0030437 ascospore formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0CD91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CE41-1", "uniprot_id": "HAP1_YEAST", "mass": 166108.0, "length": 1502, "protein_name": "Heme-responsive zinc finger transcription factor HAP1", "gene_name": "HAP1", "organism": "Yeast", "refseq_name": "Hap1p", "refseq_ac": "NP_013357", "gene_names_uniprotkb": "HAP1; CYP1; L9672.1", "gene_names_refseq": "CYP1; HAP1", "protein_names_uniprotkb": "Heme-responsive zinc finger transcription factor HAP1; CYP1 activatory protein; Heme activator protein 1", "protein_names_refseq": "Hap1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR256W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10541856;17563356;18407956;19779198;23749301;24374639;32597660;33481703;33491328;33502312;9169871", "class_list": "", "function": "Regulation of oxygen dependent gene expression. It modulates the expression of Iso-1 (CYP1) and Iso-2 (CYP3) cytochrome c. In response to heme, promotes transcription of genes encoding functions required for respiration, controlling oxidative damage and repression of anaerobic genes. Binds to the sequence 5'-CGGNNNTNNCGG-3' (By similarity). Is non-functional in terms of iso-1 cytochrome c expression in strain S288c and its derivatives., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYQ2;P12351;Q06574;Q6BD21", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P0CE41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CG63-1", "uniprot_id": "UBI4P_YEAST", "mass": 42826.0, "length": 381, "protein_name": "Polyubiquitin", "gene_name": "UBI4", "organism": "Yeast", "refseq_name": "ubiquitin", "refseq_ac": "NP_013061", "gene_names_uniprotkb": "UBI4; SCD2", "gene_names_refseq": "SCD2; UB14; UBI4", "protein_names_uniprotkb": "Polyubiquitin", "protein_names_refseq": "ubiquitin", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL039C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10406793;11591345;12628920;12787503;24374639;28757607;29130884;3038523;33074099;6095120;7615550;7862120;9169871", "class_list": "", "function": "Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXW7;P04838;P61864;Q6LA96", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P0CG63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CH08-1", "uniprot_id": "RL40A_YEAST", "mass": 14554.0, "length": 128, "protein_name": "Ubiquitin-ribosomal protein eL40A fusion protein", "gene_name": "RPL40A", "organism": "Yeast", "refseq_name": "ubiquitin-60S ribosomal protein eL40 RPL40A fusion protein", "refseq_ac": "NP_012118", "gene_names_uniprotkb": "RPL40A; UBI1", "gene_names_refseq": "CEP52A; RPL40A; UB11; UBI1", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40A fusion protein; 60S ribosomal protein L40-A; CEP52", "protein_names_refseq": "ubiquitin-60S ribosomal protein eL40 RPL40A fusion protein", "tax_id": 559292, "disease": "colon carcinoma (Disease Ontology:DOID:1520)", "pathway": " (sce:YIL148W); (sce:YKR094C)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14562095;14562106;18407956;19779198;21109664;22096102;22106047;22814378;23142985;23169626;23749301;24374639;24524803;3038523;7615550;7862120;9169870;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2 (PubMed:23169626)., [UniProtKB, PubMed, PubMed]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVD9;P04838;P14796;P61864;Q6LA96", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0042254 ribosome biogenesis;GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P0CH08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CH09-1", "uniprot_id": "RL40B_YEAST", "mass": 14554.0, "length": 128, "protein_name": "Ubiquitin-ribosomal protein eL40B fusion protein", "gene_name": "RPL40B", "organism": "Yeast", "refseq_name": "ubiquitin-60S ribosomal protein eL40 RPL40B fusion protein", "refseq_ac": "NP_013020", "gene_names_uniprotkb": "RPL40B; UBI2", "gene_names_refseq": "CEP52B; RPL40B; UB12; UBI2", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40B fusion protein; 60S ribosomal protein L40-B; CEP52", "protein_names_refseq": "ubiquitin-60S ribosomal protein eL40 RPL40B fusion protein", "tax_id": 559292, "disease": "colon carcinoma (Disease Ontology:DOID:1520)", "pathway": " (sce:YIL148W); (sce:YKR094C)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562095;14562106;18407956;19684113;19779198;22096102;22106047;22814378;23169626;24374639;24524803;3038523;7615550;7862120;8154186;8196765;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2 (PubMed:23169626)., [UniProtKB, PubMed, PubMed]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVD9;P04838;P14796;P61864;Q6LA96", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0042254 ribosome biogenesis;GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0CH09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CS90-1", "uniprot_id": "HSP77_YEAST", "mass": 70628.0, "length": 654, "protein_name": "Import motor subunit, mitochondrial", "gene_name": "SSC1", "organism": "Yeast", "refseq_name": "Hsp70 family ATPase SSC1", "refseq_ac": "NP_012579", "gene_names_uniprotkb": "SSC1; ENS1; J1639", "gene_names_refseq": "ENS1; SSC1", "protein_names_uniprotkb": "Import motor subunit, mitochondrial; 3.6.4.10; Endo.SceI 75 kDa subunit; Endonuclease SceI 75 kDa subunit; mtHSP70", "protein_names_refseq": "Hsp70 family ATPase SSC1", "tax_id": 559292, "disease": "autosomal dominant sideroblastic anemia 4 (Disease Ontology:DOID:0060335); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (sce:YJR045C); (R-SCE-3371453); (R-SCE-9837999); (R-SCE-9865881)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10779357;12032075;14517234;16107694;17761666;18086883;18407956;19779198;21126336;2265609;22814378;23749301;24374639;2674677;30516470;32597660;33481703;33491328;7625280;7668047;8641269", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein. Required for the import of the processed frataxin homolog YFH1 into the mitochondrion., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWL6;P12398", "ec_number_list": "3.5.3.1;7.1.2.2;2.3.3.1;3.6.4.13;5.6.2.3;7.1.1.8;4.2.1.2;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;4.98.1.1;5.6.1.4;4.2.1.3;1.2.4.2;1.1.1.37;3.6.4.12;2.8.1.7;3.6.4.6;5.6.2.5;1.2.4.1;3.6.1.-;2.3.2.27;3.4.21.53;3.1.-.-;2.3.1.41;3.4.24.-;3.6.5.-;1.2.1.4;1.2.1.5;6.1.1.5;2.3.3.10;1.16.3.1;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0043335 protein unfolding;GO:0000018 regulation of DNA recombination;GO:0006886 intracellular protein transport;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P0CS90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CT04-1", "uniprot_id": "IPB2_YEAST", "mass": 8590.0, "length": 75, "protein_name": "Protease B inhibitor 2", "gene_name": "PBI2", "organism": "Yeast", "refseq_name": "Pbi2p", "refseq_ac": "NP_014383", "gene_names_uniprotkb": "PBI2; N2844", "gene_names_refseq": "LMA1; PBI2", "protein_names_uniprotkb": "Protease B inhibitor 2; Proteinase inhibitor I(B)2", "protein_names_refseq": "Pbi2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL015W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "1100120;12914955;14562095;17322287;17330950;18407956;19684113;19779198;19795423;19823750;2015812;23749301;24374639;32597660;328499;33481703;33491328;387783;9015301;9159115;9169873;9657146", "class_list": "", "function": "Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1G3;P01095", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0015031 protein transport;GO:0030162 regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P0CT04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX27-1", "uniprot_id": "RL44A_YEAST", "mass": 12212.0, "length": 106, "protein_name": "Large ribosomal subunit protein eL42A", "gene_name": "RPL42A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL42 RPL42A", "refseq_ac": "NP_014237", "gene_names_uniprotkb": "RPL42A; N1722; RPL41A; SCL41A", "gene_names_refseq": "RPL42A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL42A; 60S ribosomal protein L42-A; L41; YL27; YP44", "protein_names_refseq": "60S ribosomal protein eL42 RPL42A", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR141C); (sce:YNL162W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 17, "publication_id_list": "11701127;11983894;14562095;14562106;14976550;1729213;18957409;21109664;22096102;22522802;24374639;24517342;24524803;365584;8686380;9169873;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL90;P02405", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0046677 response to antibiotic;GO:0002181 cytoplasmic translation;GO:0046898 response to cycloheximide", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0CX27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX28-1", "uniprot_id": "RL44B_YEAST", "mass": 12212.0, "length": 106, "protein_name": "Large ribosomal subunit protein eL42B", "gene_name": "RPL42B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL42 RPL42B", "refseq_ac": "NP_012010", "gene_names_uniprotkb": "RPL42B; MAK18; RPL41B; SCL41B", "gene_names_refseq": "MAK18; RPL42B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL42B; 60S ribosomal protein L42-B; L41; Maintenance of killer protein 18; YL27; YP44", "protein_names_refseq": "60S ribosomal protein eL42 RPL42B", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR141C); (sce:YNL162W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "11983894;14562095;14562106;1729213;18957409;22096102;22522802;24374639;24517342;24524803;365584;7751301;8091229;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. 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The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. 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The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRR6;P26787;P40213", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030686 90S preribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006413 translational initiation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0CX51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX53-1", "uniprot_id": "RL12A_YEAST", "mass": 17823.0, "length": 165, "protein_name": "Large ribosomal subunit protein uL11A", "gene_name": "RPL12A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL11 RPL12A", "refseq_ac": "NP_010860", "gene_names_uniprotkb": "RPL12A; RPL15B", "gene_names_refseq": "RPL12A", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11A; 60S ribosomal protein L12-A; L15; YL23", "protein_names_refseq": "60S ribosomal protein uL11 RPL12A", "tax_id": 559292, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YDR418W); (sce:YEL054C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 27, "publication_id_list": "11701127;11856739;11875433;11983894;14562095;14562106;14976550;17005568;17322287;18407956;18782943;18957409;19779198;20481588;20702584;21109664;2167467;22096102;22106047;22218487;24374639;24524803;27821475;30516470;33491328;9169868;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ6;P05741;P17079", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly;GO:0034517 ribophagy", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P0CX53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX54-1", "uniprot_id": "RL12B_YEAST", "mass": 17823.0, "length": 165, "protein_name": "Large ribosomal subunit protein uL11B", "gene_name": "RPL12B", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL11 RPL12B", "refseq_ac": "NP_010706", "gene_names_uniprotkb": "RPL12B; D9461.7; RPL15A", "gene_names_refseq": "RPL12B", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11B; 60S ribosomal protein L12-B; L15; YL23", "protein_names_refseq": "60S ribosomal protein uL11 RPL12B", "tax_id": 559292, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YDR418W); (sce:YEL054C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 29, "publication_id_list": "11856739;11875433;11983894;14562095;14562106;15665377;17005568;17563356;18407956;18782943;18957409;19684113;19779198;19795423;19823750;20481588;20702584;21126336;21177495;2167467;22096102;22106047;23749301;24374639;24524803;27821475;32597660;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ6;P05741;P17079", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly;GO:0034517 ribophagy", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P0CX54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX55-1", "uniprot_id": "RS18A_YEAST", "mass": 17038.0, "length": 146, "protein_name": "Small ribosomal subunit protein uS13A", "gene_name": "RPS18A", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS13 RPS18A", "refseq_ac": "NP_010738", "gene_names_uniprotkb": "RPS18A; D9461.35", "gene_names_refseq": "RPS18A", "protein_names_uniprotkb": "Small ribosomal subunit protein uS13A; 40S ribosomal protein S18-A", "protein_names_refseq": "40S ribosomal protein uS13 RPS18A", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR450W); (sce:YML026C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 13, "publication_count": 17, "publication_id_list": "10601260;11701127;14562095;14562106;14976550;19779198;21109664;22096102;22106047;22522802;22814378;23749301;24374639;24524803;32597660;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT75;P35271", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0015935 small ribosomal subunit;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0CX55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX56-1", "uniprot_id": "RS18B_YEAST", "mass": 17038.0, "length": 146, "protein_name": "Small ribosomal subunit protein uS13B", "gene_name": "RPS18B", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS13 RPS18B", "refseq_ac": "NP_013686", "gene_names_uniprotkb": "RPS18B", "gene_names_refseq": "RPS18B", "protein_names_uniprotkb": "Small ribosomal subunit protein uS13B; 40S ribosomal protein S18-B", "protein_names_refseq": "40S ribosomal protein uS13 RPS18B", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR450W); (sce:YML026C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 13, "publication_count": 16, "publication_id_list": "10601260;14562095;14562106;19779198;19795423;19823750;22096102;22106047;22522802;22814378;24374639;24524803;33491328;8096171;9169872;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT75;P35271", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0015935 small ribosomal subunit;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P0CX56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX63-1", "uniprot_id": "YF21B_YEAST", "mass": 202039.0, "length": 1770, "protein_name": "Transposon Ty2-F Gag-Pol polyprotein", "gene_name": "TY2B-F", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TY2B-F; FN01; YFLWTy2-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty2-F Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL002W-A); (sce:YGR161W-B)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16093660;24374639;7670463;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTM7;Q05369;Q12503", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0CX63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX64-1", "uniprot_id": "YG22B_YEAST", "mass": 202039.0, "length": 1770, "protein_name": "Transposon Ty2-GR2 Gag-Pol polyprotein", "gene_name": "TY2B-GR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058163", "gene_names_uniprotkb": "TY2B-GR2; G7017; YGRWTy2-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty2-GR2 Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL002W-A); (sce:YGR161W-B)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16093660;24374639;9169869;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTM7;Q05369;Q12503", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0CX64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX77-1", "uniprot_id": "ASP22_YEAST", "mass": 38687.0, "length": 362, "protein_name": "L-asparaginase 2-2", "gene_name": "ASP3-2", "organism": "Yeast", "refseq_name": "asparaginase ASP3-2", "refseq_ac": "NP_013258", "gene_names_uniprotkb": "ASP3-2; L9632.7", "gene_names_refseq": "ASP3-2; ASP3", "protein_names_uniprotkb": "L-asparaginase 2-2; 3.5.1.1; ASP II; L-asparaginase II; L-asparagine amidohydrolase II", "protein_names_refseq": "asparaginase ASP3-2", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR155C); (sce:YLR157C); (sce:YLR158C); (sce:YLR160C)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17322287;24374639;3042786;342521;6986375;6995441;9169871", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VYF3;P11163;Q12268;Q6Q5K8;Q6Q5K9", "ec_number_list": "3.5.1.1", "go_molecular_function": "GO:0004067 asparaginase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0042597 periplasmic space;GO:0030287 cell wall-bounded periplasmic space", "go_biological_process": "GO:0006995 cellular response to nitrogen starvation;GO:0006530 L-asparagine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0CX77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX78-1", "uniprot_id": "ASP23_YEAST", "mass": 38687.0, "length": 362, "protein_name": "L-asparaginase 2-3", "gene_name": "ASP3-3", "organism": "Yeast", "refseq_name": "asparaginase ASP3-3", "refseq_ac": "NP_013259", "gene_names_uniprotkb": "ASP3-3; L9632.8", "gene_names_refseq": "ASP3-3; ASP3", "protein_names_uniprotkb": "L-asparaginase 2-3; 3.5.1.1; ASP II; L-asparaginase II; L-asparagine amidohydrolase II", "protein_names_refseq": "asparaginase ASP3-3", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR155C); (sce:YLR157C); (sce:YLR158C); (sce:YLR160C)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "24374639;3042786;342521;6986375;6995441;9169871", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VYF3;P11163;Q12268;Q6Q5K8;Q6Q5K9", "ec_number_list": "3.5.1.1", "go_molecular_function": "GO:0004067 asparaginase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0042597 periplasmic space;GO:0030287 cell wall-bounded periplasmic space", "go_biological_process": "GO:0006995 cellular response to nitrogen starvation;GO:0006530 L-asparagine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0CX78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX79-1", "uniprot_id": "ASP24_YEAST", "mass": 38687.0, "length": 362, "protein_name": "L-asparaginase 2-4", "gene_name": "ASP3-4", "organism": "Yeast", "refseq_name": "asparaginase ASP3-4", "refseq_ac": "NP_013261", "gene_names_uniprotkb": "ASP3-4; L9632.9", "gene_names_refseq": "ASP3-4; ASP3", "protein_names_uniprotkb": "L-asparaginase 2-4; 3.5.1.1; ASP II; L-asparaginase II; L-asparagine amidohydrolase II", "protein_names_refseq": "asparaginase ASP3-4", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR155C); (sce:YLR157C); (sce:YLR158C); (sce:YLR160C)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "24374639;3042786;342521;6986375;6995441;9169871", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VYF3;P11163;Q12268;Q6Q5K8;Q6Q5K9", "ec_number_list": "3.5.1.1", "go_molecular_function": "GO:0004067 asparaginase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0071944 cell periphery;GO:0042597 periplasmic space;GO:0030287 cell wall-bounded periplasmic space", "go_biological_process": "GO:0006995 cellular response to nitrogen starvation;GO:0006530 L-asparagine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0CX79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX80-1", "uniprot_id": "MTCU1_YEAST", "mass": 6650.0, "length": 61, "protein_name": "Copper metallothionein 1-1", "gene_name": "CUP1-1", "organism": "Yeast", "refseq_name": "metallothionein CUP1-1", "refseq_ac": "NP_011922", "gene_names_uniprotkb": "CUP1-1; MTH1", "gene_names_refseq": "CUP1-1; CUP1", "protein_names_uniprotkb": "Copper metallothionein 1-1; Copper chelatin; Copper thionein; Cu-MT; Cu-metallothionein", "protein_names_refseq": "metallothionein CUP1-1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR053C); (sce:YHR055C)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10672009;15613489;17322287;19779198;2017134;22106047;23749301;24374639;3286647;3902832;6364141;6374656;8091229;8566237", "class_list": "", "function": "Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL02;P07215", "ec_number_list": "", "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0016209 antioxidant activity;GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0046688 response to copper ion;GO:0019430 removal of superoxide radicals;GO:0010273 detoxification of copper ion;GO:0071585 detoxification of cadmium ion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P0CX80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX81-1", "uniprot_id": "MTCU2_YEAST", "mass": 6650.0, "length": 61, "protein_name": "Copper metallothionein 1-2", "gene_name": "CUP1-2", "organism": "Yeast", "refseq_name": "metallothionein CUP1-2", "refseq_ac": "NP_011920", "gene_names_uniprotkb": "CUP1-2; MTH1", "gene_names_refseq": "CUP1-2; CUP1", "protein_names_uniprotkb": "Copper metallothionein 1-2; Copper chelatin; Copper thionein; Cu-MT; Cu-metallothionein", "protein_names_refseq": "metallothionein CUP1-2", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR053C); (sce:YHR055C)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17322287;19779198;2017134;22106047;24374639;3286647;3902832;6364141;6374656;8091229", "class_list": "", "function": "Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL02;P07215", "ec_number_list": "", "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0016209 antioxidant activity;GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0046688 response to copper ion;GO:0019430 removal of superoxide radicals;GO:0010273 detoxification of copper ion;GO:0071585 detoxification of cadmium ion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0CX81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX82-1", "uniprot_id": "RL19A_YEAST", "mass": 21704.0, "length": 189, "protein_name": "Large ribosomal subunit protein eL19A", "gene_name": "RPL19A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL19 RPL19A", "refseq_ac": "NP_009641", "gene_names_uniprotkb": "RPL19A; RPL23A; YBR084BC; YL14A", "gene_names_refseq": "RPL19A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL19A; 60S ribosomal protein L19-A; L23; RP15L; RP33; YL14", "protein_names_refseq": "60S ribosomal protein eL19 RPL19A", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL027W); (sce:YBR084C-A); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 22, "publication_id_list": "11701127;11983894;14562095;14562106;14976550;1544921;17330950;18407956;19779198;20702584;21109664;22096102;22106047;24374639;24524803;2836393;33491328;6355773;7785339;7813418;8485583;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL19 may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPX3;P05735", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P0CX82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX83-1", "uniprot_id": "RL19B_YEAST", "mass": 21704.0, "length": 189, "protein_name": "Large ribosomal subunit protein eL19", "gene_name": "RPL19B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL19 RPL19B", "refseq_ac": "NP_009526", "gene_names_uniprotkb": "RPL19B; RPL23B; YBL0424; YL14B", "gene_names_refseq": "RPL19B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL19; 60S ribosomal protein L19-B; L23; RP15L; RP33; YL14", "protein_names_refseq": "60S ribosomal protein eL19 RPL19B", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL027W); (sce:YBR084C-A); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 22, "publication_id_list": "11983894;14562095;14562106;1544921;15665377;17330950;18407956;19779198;20702584;21126336;22096102;22106047;23749301;24374639;24524803;32597660;6355773;7725803;7813418;8485583;8781168;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL19 may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPX3;P05735", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P0CX83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX84-1", "uniprot_id": "RL35A_YEAST", "mass": 13910.0, "length": 120, "protein_name": "Large ribosomal subunit protein uL29A", "gene_name": "RPL35A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL29 RPL35A", "refseq_ac": "NP_010145", "gene_names_uniprotkb": "RPL35A; D1249; SOS1", "gene_names_refseq": "RPL35A; SOS1", "protein_names_uniprotkb": "Large ribosomal subunit protein uL29A; 60S ribosomal protein L35-A", "protein_names_refseq": "60S ribosomal protein uL29 RPL35A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 19 (Disease Ontology:DOID:0111886)", "pathway": " (sce:YDL136W); (sce:YDL191W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 18, "publication_id_list": "11701127;11983894;14562095;14976550;19779198;19933108;20980660;21109664;22096102;22814378;23142985;24374639;24524803;33491328;8513501;8896272;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRG2;P39741;P39930", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P0CX84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX85-1", "uniprot_id": "RL35B_YEAST", "mass": 13910.0, "length": 120, "protein_name": "Large ribosomal subunit protein uL29B", "gene_name": "RPL35B", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL29 RPL35B", "refseq_ac": "NP_010090", "gene_names_uniprotkb": "RPL35B; D2170; SOS2", "gene_names_refseq": "RPL35B; SOS2", "protein_names_uniprotkb": "Large ribosomal subunit protein uL29B; 60S ribosomal protein L35-B", "protein_names_refseq": "60S ribosomal protein uL29 RPL35B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 19 (Disease Ontology:DOID:0111886)", "pathway": " (sce:YDL136W); (sce:YDL191W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 17, "publication_id_list": "11701127;11983894;14562095;14562106;14976550;18407956;19779198;22096102;22814378;23749301;24374639;24524803;32597660;8513501;8972577;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRG2;P39741;P39930", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0CX85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CY06-1", "uniprot_id": "MTAL1_YEAST", "mass": 20413.0, "length": 175, "protein_name": "Mating-type protein ALPHA1", "gene_name": "MATALPHA1", "organism": "Yeast", "refseq_name": "transcriptional co-activator mating type protein alpha", "refseq_ac": "NP_009869", "gene_names_uniprotkb": "MATALPHA1; ALPHA-1; MAT1A; MATAL1; YCR40W", "gene_names_refseq": "ALPHA1; MATALPHA1", "protein_names_uniprotkb": "Mating-type protein ALPHA1; Alpha-1 activator; MATalpha1 protein", "protein_names_refseq": "transcriptional co-activator mating type protein alpha", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL066W); (sce:YCR040W)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1574125;17322287;1756728;1789011;24374639;33502312;7021055;8339934;8413280;8664541", "class_list": "", "function": "Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional coactivator that, in alpha-cells, binds cooperatively with MCM1 and STE12 to a DNA sequence termed the QP' element, to activate the transcription of alpha-specific genes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQV3;P01365", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007532 regulation of mating-type specific transcription, DNA-templated;GO:0045895 positive regulation of mating-type specific transcription, DNA-templated", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0CY06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CY08-1", "uniprot_id": "MTAL2_YEAST", "mass": 24282.0, "length": 210, "protein_name": "Mating-type protein ALPHA2", "gene_name": "MATALPHA2", "organism": "Yeast", "refseq_name": "homeodomain mating type protein alpha2", "refseq_ac": "NP_009868", "gene_names_uniprotkb": "MATALPHA2; ALPHA-2; MAT2A; MATAL2; YCR39C", "gene_names_refseq": "ALPHA2; MATALPHA2", "protein_names_uniprotkb": "Mating-type protein ALPHA2; Alpha-2 repressor; MATalpha2 protein", "protein_names_refseq": "homeodomain mating type protein alpha2", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL067C); (sce:YCR039C)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10759558;12121651;12466549;1574125;1673952;1682054;17322287;1789011;20110468;24374639;2851482;2887035;3061876;3893743;6429549;7021055;7498787;7569974;7995523;8628280;8664541;9490409;9838003", "class_list": "", "function": "Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that binds cooperatively with MCM1 to a 31-basepair DNA sequence termed the a-specific gene (asg) operator, to repress the transcription of a-cell-specific genes. Additionally, in a/alpha diploid cells, binds cooperatively with the A1 protein to a 21-basepair DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQV2;P01367;P01368;Q6B2C0", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007532 regulation of mating-type specific transcription, DNA-templated", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P0CY08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CZ17-1", "uniprot_id": "ASP21_YEAST", "mass": 38687.0, "length": 362, "protein_name": "L-asparaginase 2-1", "gene_name": "ASP3-1", "organism": "Yeast", "refseq_name": "asparaginase ASP3-1", "refseq_ac": "NP_013256", "gene_names_uniprotkb": "ASP3-1; L9632.6", "gene_names_refseq": "ASP3-1; ASP3", "protein_names_uniprotkb": "L-asparaginase 2-1; 3.5.1.1; ASP II; L-asparaginase II; L-asparagine amidohydrolase II", "protein_names_refseq": "asparaginase ASP3-1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR155C); (sce:YLR157C); (sce:YLR158C); (sce:YLR160C)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17322287;24374639;3042786;342521;6986375;6995441;9169871", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VYF3;P11163;Q12268;Q6Q5K8;Q6Q5K9", "ec_number_list": "3.5.1.1", "go_molecular_function": "GO:0004067 asparaginase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0042597 periplasmic space;GO:0030287 cell wall-bounded periplasmic space", "go_biological_process": "GO:0006995 cellular response to nitrogen starvation;GO:0006530 L-asparagine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0CZ17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10080-1", "uniprot_id": "SSBP1_YEAST", "mass": 32990.0, "length": 294, "protein_name": "Single-stranded nucleic acid-binding protein", "gene_name": "SBP1", "organism": "Yeast", "refseq_name": "Sbp1p", "refseq_ac": "NP_011829", "gene_names_uniprotkb": "SBP1; SSB1; SSBR1", "gene_names_refseq": "SBP1; SSB1; SSBR1", "protein_names_uniprotkb": "Single-stranded nucleic acid-binding protein", "protein_names_refseq": "Sbp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL034C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "1429834;14562095;14562106;16782896;17287358;17330950;17563356;18407956;19779198;19795423;19823750;21126336;21177495;2121740;22218487;22814378;23222640;23749301;24374639;26046779;2823109;32597660;33481703;33491328;33856219;8091229", "class_list": "", "function": "Functions in the transition of mRNAs from translation to an mRNP complex destined for decapping. High-copy-number suppressor of decapping defects. Overexpression suppresses decapping defects in both DCP1-2 and DCP2-7 mutations. Acts to promote translational repression of mRNA in conjunction with DHH1 and subsequent mRNA localization to P bodies. Promotes translational repression of mRNA during glucose deprivation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKT4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0031370 eukaryotic initiation factor 4G binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0032055 negative regulation of translation in response to stress;GO:0017148 negative regulation of translation;GO:0045947 negative regulation of translational initiation;GO:0035617 stress granule disassembly", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P10080-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10081-1", "uniprot_id": "IF4A_YEAST", "mass": 44697.0, "length": 395, "protein_name": "ATP-dependent RNA helicase eIF4A", "gene_name": "TIF1; TIF2", "organism": "Yeast", "refseq_name": "translation initiation factor eIF4A", "refseq_ac": "NP_012397", "gene_names_uniprotkb": "TIF1; TIF2; J0660; TIF41A; TIF41B", "gene_names_refseq": "TIF2", "protein_names_uniprotkb": "ATP-dependent RNA helicase eIF4A; 3.6.4.13; Eukaryotic initiation factor 4A; Stimulator factor I 37 kDa component; Translation initiation factor 1/2; eIF-4A; p37", "protein_names_refseq": "translation initiation factor eIF4A", "tax_id": 559292, "disease": "neurodevelopmental disorder with hypotonia and speech delay (Disease Ontology:DOID:0070512)", "pathway": " (sce:YJL138C); (sce:YKR059W); (R-SCE-156827); (R-SCE-429947); (R-SCE-72649); (R-SCE-72662); (R-SCE-72702)", "pathway_count": 7, "publication_count": 39, "publication_id_list": "10404596;10409745;10480875;10606264;11087862;12535527;1408806;14562095;14562106;1502180;15665377;17330950;18407956;19779198;19795423;19823750;2041753;2046664;20702584;21126336;2169890;22218487;22814378;23749301;24374639;24909858;2648398;2668952;27821475;3057442;32597660;33481703;33491328;34965436;8196765;8524228;8641269;8813765;9298649", "class_list": "", "function": "ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW46", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.5.3;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;3.1.13.4;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0005840 ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:1901195 positive regulation of formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P10081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10127-1", "uniprot_id": "ADH4_YEAST", "mass": 41142.0, "length": 382, "protein_name": "Alcohol dehydrogenase 4", "gene_name": "ADH4", "organism": "Yeast", "refseq_name": "alcohol dehydrogenase ADH4", "refseq_ac": "NP_011258", "gene_names_uniprotkb": "ADH4; NRC465; ZRG5", "gene_names_refseq": "ADH4; NRC465; ZRG5", "protein_names_uniprotkb": "Alcohol dehydrogenase 4; 1.1.1.1; ADHIV; Alcohol dehydrogenase IV", "protein_names_refseq": "alcohol dehydrogenase ADH4", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL256W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10884426;10978274;14562095;14562106;16503288;17139254;17933919;17938904;2193925;22094012;24374639;2823079;3023838;3282541;8972578;9169869", "class_list": "", "function": "Alcohol dehydrogenase specific for ethanol. Acts mainyl as a mitochondrial formaldehyde dehydrogenase and has no effect on ethanol production (PubMed:2193925). Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward. Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all (PubMed:17938904, PubMed:3282541). The role of ADH4 in yeast metabolism is not yet known, but ADH4 is not responsible for the production of ethanol during growth on glucose nor responsible for the oxidation of ethanol to acetaldehyde (PubMed:22094012)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV79", "ec_number_list": "1.1.1.1;1.1.1.54;1.1.1.78;1.1.1.-;1.1.1.284", "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0046872 metal ion binding;GO:0120542 ethanol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006066 alcohol metabolic process;GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10174-1", "uniprot_id": "COX7_YEAST", "mass": 6932.0, "length": 60, "protein_name": "Cytochrome c oxidase subunit 7, mitochondrial", "gene_name": "COX7", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit VII", "refseq_ac": "NP_013983", "gene_names_uniprotkb": "COX7; YM9920.10C", "gene_names_refseq": "COX7", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7, mitochondrial; Cytochrome c oxidase polypeptide VII", "protein_names_refseq": "cytochrome c oxidase subunit VII", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR256C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10764779;10775262;14562106;17322287;2158084;2168889;24374639;3013877;30598554;30598556;7851399;9169872", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W082", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P10174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10363-1", "uniprot_id": "PRI1_YEAST", "mass": 47690.0, "length": 409, "protein_name": "DNA primase small subunit", "gene_name": "PRI1", "organism": "Yeast", "refseq_name": "DNA primase subunit PRI1", "refseq_ac": "NP_012273", "gene_names_uniprotkb": "PRI1; YIB8C", "gene_names_refseq": "PRI1", "protein_names_uniprotkb": "DNA primase small subunit; 2.7.7.-; DNA polymerase alpha:primase complex p48 subunit; DNA polymerase-primase complex p48 subunit; DNA primase 48 kDa subunit; Pol alpha-primase complex p48 subunit", "protein_names_refseq": "DNA primase subunit PRI1", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR008C); (R-SCE-113501); (R-SCE-68952); (R-SCE-68962); (R-SCE-69091); (R-SCE-69166); (R-SCE-69183)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "14562106;17322287;18407956;2023935;21126336;24374639;3061469;3313275;33481703;33491328;7762303;9169870", "class_list": "", "function": "DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVT8", "ec_number_list": "2.7.11.22;2.7.11.1;2.7.7.-;2.7.7.7;3.1.11.-;3.6.4.12;3.1.-.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0043596 nuclear replication fork", "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P10363-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10507-1", "uniprot_id": "MPPB_YEAST", "mass": 51084.0, "length": 462, "protein_name": "Mitochondrial-processing peptidase subunit beta", "gene_name": "MAS1", "organism": "Yeast", "refseq_name": "mitochondrial processing peptidase", "refseq_ac": "NP_013264", "gene_names_uniprotkb": "MAS1; L9632.10; MIF1", "gene_names_refseq": "MAS1; MIF1", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit beta; 3.4.24.64; Beta-MPP; Mitochondrial assembly protein 1; PEP; Processing enhancing protein", "protein_names_refseq": "mitochondrial processing peptidase", "tax_id": 559292, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); multiple mitochondrial dysfunctions syndrome 6 (Disease Ontology:DOID:0070332); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (sce:YLR163C); (R-SCE-611105)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11470436;14562106;17322287;18407956;2007593;21126336;24374639;25176146;3044780;3061797;32597660;33481703;33491328;9169871;9299349;9654444", "class_list": "", "function": "Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (PubMed:2007593, PubMed:9299349, PubMed:9654444). Preferentially, cleaves after an arginine at position P2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYG9", "ec_number_list": "7.1.1.8;1.1.2.3;7.1.2.2;3.4.24.64;2.5.1.39;1.1.2.4;1.16.3.1", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10591-1", "uniprot_id": "HSP71_YEAST", "mass": 69657.0, "length": 642, "protein_name": "Heat shock protein SSA1", "gene_name": "SSA1", "organism": "Yeast", "refseq_name": "Hsp70 family ATPase SSA1", "refseq_ac": "NP_009396", "gene_names_uniprotkb": "SSA1", "gene_names_refseq": "SSA1; YG100", "protein_names_uniprotkb": "Heat shock protein SSA1; Heat shock protein YG100", "protein_names_refseq": "Hsp70 family ATPase SSA1", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); lymphoma (Disease Ontology:DOID:0060058); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); paranoid schizophrenia (Disease Ontology:DOID:1229); vitiligo (Disease Ontology:DOID:12306); cardiovascular system disease (Disease Ontology:DOID:1287); uveitis (Disease Ontology:DOID:13141); Kawasaki disease (Disease Ontology:DOID:13378); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); systolic heart failure (Disease Ontology:DOID:9651); senile cataract (Disease Ontology:DOID:9669); Meniere's disease (Disease Ontology:DOID:9849); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YAL005C); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 7, "publication_count": 27, "publication_id_list": "11279042;12761219;14562095;14562106;17287358;17563356;18086883;18407956;19779198;21126336;21177495;22106047;23217712;23749301;24374639;2644626;30516470;32205407;32597660;33481703;33491328;6096826;7731988;7895733;7941740;8935650;9298649", "class_list": "", "function": "May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA1 can participate in the ATP-dependent disassembly of clathrin-coated vesicles., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 44, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006626 protein targeting to mitochondrion;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P10591-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10592-1", "uniprot_id": "HSP72_YEAST", "mass": 69470.0, "length": 639, "protein_name": "Heat shock protein SSA2", "gene_name": "SSA2", "organism": "Yeast", "refseq_name": "Hsp70 family chaperone SSA2", "refseq_ac": "NP_013076", "gene_names_uniprotkb": "SSA2; L0931", "gene_names_refseq": "SSA2; YG102", "protein_names_uniprotkb": "Heat shock protein SSA2", "protein_names_refseq": "Hsp70 family chaperone SSA2", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); lymphoma (Disease Ontology:DOID:0060058); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); paranoid schizophrenia (Disease Ontology:DOID:1229); vitiligo (Disease Ontology:DOID:12306); cardiovascular system disease (Disease Ontology:DOID:1287); uveitis (Disease Ontology:DOID:13141); Kawasaki disease (Disease Ontology:DOID:13378); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); systolic heart failure (Disease Ontology:DOID:9651); senile cataract (Disease Ontology:DOID:9669); Meniere's disease (Disease Ontology:DOID:9849); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YLL024C); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-6798695); (R-SCE-8876725); (R-SCE-9841251)", "pathway_count": 8, "publication_count": 28, "publication_id_list": "11283598;12761219;12872131;14562106;15665377;17287358;17563356;18086883;18407956;19779198;19795423;19823750;21126336;21177495;22106047;22814378;23749301;24374639;2644626;30516470;32597660;33481703;33491328;7895733;8935650;9046100;9169871;9298649", "class_list": "", "function": "May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA2 can participate in the ATP-dependent disassembly of clathrin-coated vesicles., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 44, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXY0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006457 protein folding;GO:0009267 cellular response to starvation;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P10592-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10614-1", "uniprot_id": "CP51_YEAST", "mass": 60720.0, "length": 530, "protein_name": "Lanosterol 14-alpha demethylase CYP51", "gene_name": "ERG11", "organism": "Yeast", "refseq_name": "sterol 14-demethylase", "refseq_ac": "NP_011871", "gene_names_uniprotkb": "ERG11; CYP51", "gene_names_refseq": "CYP51; ERG11", "protein_names_uniprotkb": "Lanosterol 14-alpha demethylase CYP51; 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Ergosterol biosynthetic protein 11; Lanosterol C14-C32 lyase; Sterol 14-alpha demethylase", "protein_names_refseq": "sterol 14-demethylase", "tax_id": 559292, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (sce:YHR007C); (R-SCE-211976); (R-SCE-6807047)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "105731;14562106;15995173;16847258;1730736;17330950;18407956;1872829;21126336;22106047;23749301;24374639;24613931;28270554;3046615;32597660;32679672;3322742;33481703;33491328;3542713;3543000;369554;8091229", "class_list": "", "function": "Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:105731, PubMed:369554). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (PubMed:32679672). Starting from lanosterol (lanosta-8,24-dien-3beta-ol), it catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of the sterol in the form of formate, and converts the sterol to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, which is critical for ergosterol biosynthesis (PubMed:105731, PubMed:3543000, PubMed:369554). Can demethylate substrates not intrinsic to yeast, such as eburicol (24-methylene-24,25-dihydrolanosterol) at a similar rate to lanosterol, and at a lower rate the 24,25-dihydrolanosterol (DHL) to 4,4-dimethyl-8,14-cholestadien-3beta-ol (PubMed:1872829, PubMed:3543000)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV1", "ec_number_list": "1.14.14.154", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0008398 sterol 14-demethylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P10614-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10622-1", "uniprot_id": "RLA3_YEAST", "mass": 10668.0, "length": 106, "protein_name": "Large ribosomal subunit protein P1B", "gene_name": "RPP1B", "organism": "Yeast", "refseq_name": "ribosomal protein P1 RPP1B", "refseq_ac": "NP_010153", "gene_names_uniprotkb": "RPP1B; L12EIIB; RPL44P; RPLA3", "gene_names_refseq": "RPL44'; RPLA3; RPP1B", "protein_names_uniprotkb": "Large ribosomal subunit protein P1B; 60S acidic ribosomal protein P1-beta; Ax; L12eIIB; L44'; P1B; YP1beta", "protein_names_refseq": "ribosomal protein P1 RPP1B", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (sce:YDL130W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11080154;11431471;14562095;14562106;16573688;18407956;19795423;19823750;21126336;22096102;2404943;24374639;24524803;2837476;30516470;33481703;33491328;8428920;8476850;9169867;9398162;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM0", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0030295 protein kinase activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0045860 positive regulation of protein kinase activity;GO:0006414 translational elongation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P10622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10659-1", "uniprot_id": "METK1_YEAST", "mass": 41818.0, "length": 382, "protein_name": "S-adenosylmethionine synthase 1", "gene_name": "SAM1", "organism": "Yeast", "refseq_name": "methionine adenosyltransferase SAM1", "refseq_ac": "NP_013281", "gene_names_uniprotkb": "SAM1; ETH10; L9470.9", "gene_names_refseq": "ETH10; SAM1", "protein_names_uniprotkb": "S-adenosylmethionine synthase 1; 2.5.1.6; AdoMet synthase 1; MAT 1; Methionine adenosyltransferase 1", "protein_names_refseq": "methionine adenosyltransferase SAM1", "tax_id": 559292, "disease": "hypermethioninemia (Disease Ontology:DOID:0050544); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); lung cancer (Disease Ontology:DOID:1324); lipid metabolism disorder (Disease Ontology:DOID:3146); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YLR180W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;23749301;24374639;3316224;33481703;33491328;8935650;9169871", "class_list": "", "function": "Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYI4", "ec_number_list": "2.5.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004478 methionine adenosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006730 one-carbon metabolic process;GO:0040029 epigenetic regulation of gene expression;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0006555 methionine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10659-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10664-1", "uniprot_id": "RL4A_YEAST", "mass": 39092.0, "length": 362, "protein_name": "Large ribosomal subunit protein uL4A", "gene_name": "RPL4A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL4 RPL4A", "refseq_ac": "NP_009587", "gene_names_uniprotkb": "RPL4A; RPL2A; RPL2; YBR0315", "gene_names_refseq": "RPL4A", "protein_names_uniprotkb": "Large ribosomal subunit protein uL4A; 60S ribosomal protein L4-A; L2; RP2; YL2", "protein_names_refseq": "60S ribosomal protein uL4 RPL4A", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR031W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 25, "publication_id_list": "11701127;14562095;1544921;17287358;17330950;17563356;18407956;19779198;2065661;20702584;21109664;21126336;22096102;23749301;24374639;24524803;25936803;26046779;2834365;30516470;32597660;33481703;7813418;8091864;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uL4 participates in the regulation of the accumulation of its own mRNA (PubMed:2065661)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ32", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P10664-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10823-1", "uniprot_id": "GPA2_YEAST", "mass": 50448.0, "length": 449, "protein_name": "Guanine nucleotide-binding protein alpha-2 subunit", "gene_name": "GPA2", "organism": "Yeast", "refseq_name": "guanine nucleotide-binding protein subunit alpha", "refseq_ac": "NP_010937", "gene_names_uniprotkb": "GPA2; SSP101", "gene_names_refseq": "GPA2; SSP101", "protein_names_uniprotkb": "Guanine nucleotide-binding protein alpha-2 subunit; GP2-alpha", "protein_names_refseq": "guanine nucleotide-binding protein subunit alpha", "tax_id": 559292, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); developmental and epileptic encephalopathy 17 (Disease Ontology:DOID:0080450); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108); achromatopsia 4 (Disease Ontology:DOID:0110010); congenital stationary night blindness 1G (Disease Ontology:DOID:0110714); congenital stationary night blindness autosomal dominant 3 (Disease Ontology:DOID:0110715); inflammatory bowel disease 12 (Disease Ontology:DOID:0110887); familial multiple nevi flammei (Disease Ontology:DOID:0111529); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); hypertension (Disease Ontology:DOID:10763); color blindness (Disease Ontology:DOID:13399); achromatopsia (Disease Ontology:DOID:13911); lung non-small cell carcinoma (Disease Ontology:DOID:3908); congestive heart failure (Disease Ontology:DOID:6000); night blindness (Disease Ontology:DOID:8499); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YER020W); (R-SCE-2514859); (R-SCE-418594)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10523302;11875433;12150916;14562095;14562106;16030250;17563356;18407956;19779198;20702584;21126336;23749301;24374639;2830616;32597660;33481703;33491328;34965436;9169868", "class_list": "", "function": "Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) involved in glucose-induced cAMP signaling. Binds to its cognate transmembrane receptor GPR1, which senses extracellular carbon sources, and activates cAMP-PKA signaling and governs diploid pseudohyphal differentiation and haploid invasive growth. The G protein beta-mimic proteins GPB1 and GPB2 inhibit GPA2-GPR1 coupling, probably to reduce signaling in the absence of glucose., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR9", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010255 glucose mediated signaling pathway;GO:0008361 regulation of cell size;GO:0001403 invasive growth in response to glucose limitation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P10823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10862-1", "uniprot_id": "RAD18_YEAST", "mass": 55230.0, "length": 487, "protein_name": "Postreplication repair E3 ubiquitin-protein ligase RAD18", "gene_name": "RAD18", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase RAD18", "refseq_ac": "NP_009992", "gene_names_uniprotkb": "RAD18; YCR66W", "gene_names_refseq": "RAD18", "protein_names_uniprotkb": "Postreplication repair E3 ubiquitin-protein ligase RAD18; 2.3.2.27; RING-type E3 ubiquitin transferase RAD18; Radiation sensitivity protein 18", "protein_names_refseq": "E3 ubiquitin-protein ligase RAD18", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR066W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10880451;10924462;12226657;14562106;15388802;15507115;1561837;1574125;16247017;17287358;18407956;19779198;20702584;21126336;22106047;23749301;24374639;27017623;2970061;3073108;32597660;33481703;33491328;7926769;9287349", "class_list": "", "function": "Together with the E2 ubiquitin conjugating enzyme RAD6/UBC2, monoubiquitinates POL30/PCNA on 'Lys-164' to promote two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypasses replication-blocking lesions without removing them; monoubiquitination promotes the translesion synthesis (TLS) pathway and leads to the recruitment of translesion polymerases for lesion bypass, whereas further polyubiquitination of PCNA by MMS2-UBC13-RAD5, promotes template-switching (TS) to the newly synthesized sister chromatid for synthesis past the lesion (PubMed:10880451, PubMed:10924462, PubMed:12226657, PubMed:15388802, PubMed:15507115, PubMed:16247017, PubMed:7926769, PubMed:9287349). Has single-stranded DNA-binding activity (PubMed:7926769)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VR69;Q58AT6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0097505 Rad6-Rad18 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0042276 error-prone translesion synthesis;GO:0006301 DNA damage tolerance;GO:0006513 protein monoubiquitination;GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P10862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10863-1", "uniprot_id": "TIR1_YEAST", "mass": 24906.0, "length": 254, "protein_name": "Cold shock-induced protein TIR1", "gene_name": "TIR1", "organism": "Yeast", "refseq_name": "GPI-anchored mannoprotein", "refseq_ac": "NP_010927", "gene_names_uniprotkb": "TIR1; SRP1", "gene_names_refseq": "SRP1; TIR1", "protein_names_uniprotkb": "Cold shock-induced protein TIR1; Serine-rich protein 1; TIP1-related protein 1", "protein_names_refseq": "GPI-anchored mannoprotein", "tax_id": 559292, "disease": "", "pathway": " (sce:YER011W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11292809;14562106;15781460;16086015;24374639;3139887;7746155;9169868", "class_list": "", "function": "Component of the cell wall. Required for anaerobic growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLQ8", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0071944 cell periphery;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10870-1", "uniprot_id": "SNF3_YEAST", "mass": 96719.0, "length": 884, "protein_name": "Low glucose sensor SNF3", "gene_name": "SNF3", "organism": "Yeast", "refseq_name": "glucose sensor", "refseq_ac": "NP_010087", "gene_names_uniprotkb": "SNF3; D1234", "gene_names_refseq": "SNF3", "protein_names_uniprotkb": "Low glucose sensor SNF3; High-affinity glucose receptor SNF3; High-affinity transporter-like sensor SNF3; Sucrose nonfermenting protein 3", "protein_names_refseq": "glucose sensor", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL194W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "16847258;18407956;19779198;20014043;21177495;22814378;23749301;2406560;24374639;32597660;3281163;33481703;33491328;6392017;8896272;8901598;9046082;9169867;9564039", "class_list": "", "function": "High-affinity low glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:8901598, PubMed:9564039). The transporter-like sensor generates an intracellular signal in the presence of low levels of glucose to promote low glucose-induced expression of HXT2 (PubMed:9564039). Binding of glucose to the SNF3 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (By similarity). SNF3 is involved as well in the transport of mannose and fructose (PubMed:20014043). Even though SNF3 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRF9", "ec_number_list": "", "go_molecular_function": "GO:0005351 carbohydrate:proton symporter activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0008643 carbohydrate transport;GO:0015755 fructose transmembrane transport;GO:0045835 negative regulation of meiotic nuclear division;GO:0010255 glucose mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P10870-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10961-1", "uniprot_id": "HSF_YEAST", "mass": 93282.0, "length": 833, "protein_name": "Heat shock transcription factor", "gene_name": "HSF1", "organism": "Yeast", "refseq_name": "stress-responsive transcription factor HSF1", "refseq_ac": "NP_011442", "gene_names_uniprotkb": "HSF1", "gene_names_refseq": "EXA3; HSF1; MAS3", "protein_names_uniprotkb": "Heat shock transcription factor; HSF; HSTF; Heat shock factor protein", "protein_names_refseq": "stress-responsive transcription factor HSF1", "tax_id": 559292, "disease": "cataract 5 multiple types (Disease Ontology:DOID:0110255); Alzheimer's disease (Disease Ontology:DOID:10652); cryptorchidism (Disease Ontology:DOID:11383); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767); cataract (Disease Ontology:DOID:83)", "pathway": " (sce:YGL073W); (R-SCE-3371453); (R-SCE-3371511); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-9841251)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "12743037;17330950;17563356;18407956;19779198;21177495;22218487;22814378;23749301;24374639;3044612;3044613;31208443;32597660;33229814;33481703;33491328;8175654;9169869;9290212", "class_list": "", "function": "DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VU70;P11529", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0043555 regulation of translation in response to stress;GO:0070202 regulation of establishment of protein localization to chromosome;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P10961-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10962-1", "uniprot_id": "MAK16_YEAST", "mass": 35696.0, "length": 306, "protein_name": "Protein MAK16", "gene_name": "MAK16", "organism": "Yeast", "refseq_name": "ribosome biosynthesis protein MAK16", "refseq_ac": "NP_009377", "gene_names_uniprotkb": "MAK16", "gene_names_refseq": "MAK16", "protein_names_uniprotkb": "Protein MAK16; Maintenance of killer protein 16", "protein_names_refseq": "ribosome biosynthesis protein MAK16", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL025C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19779198;20702584;24374639;3045810;33481703;33491328;7731988", "class_list": "", "function": "Its role might be as part of the apparatus concerned with the nuclear events of the cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPJ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000460 maturation of 5.8S rRNA;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10964-1", "uniprot_id": "RPA1_YEAST", "mass": 186432.0, "length": 1664, "protein_name": "DNA-directed RNA polymerase I subunit RPA190", "gene_name": "RPA190", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase I core subunit RPA190", "refseq_ac": "NP_014986", "gene_names_uniprotkb": "RPA190; O6276; RPA1; RRN1", "gene_names_refseq": "RPA190; RRN1", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA190; 2.7.7.6; A190; DNA-directed RNA polymerase I 190 kDa polypeptide; DNA-directed RNA polymerase I largest subunit", "protein_names_refseq": "DNA-directed RNA polymerase I core subunit RPA190", "tax_id": 559292, "disease": "acrofacial dysostosis Cincinnati type (Disease Ontology:DOID:0060353); hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786)", "pathway": " (sce:YOR341W); (R-SCE-73762); (R-SCE-73772)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "11717393;11875433;11918799;12145213;12407181;14562095;14562106;17330950;18084032;18160037;18407956;19779198;19795423;19823750;21126336;23749301;24153182;24153184;24374639;2830265;32597660;33481703;33491328;8948102;9169874", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W336;Q99330", "ec_number_list": "2.7.7.6;2.7.11.23;5.6.2.3;5.6.2.4", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:1990841 promoter-specific chromatin binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P10964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11075-1", "uniprot_id": "SEC7_YEAST", "mass": 226886.0, "length": 2009, "protein_name": "ADP-ribosylation factor guanine nucleotide-exchange factor SEC7", "gene_name": "SEC7", "organism": "Yeast", "refseq_name": "Arf family guanine nucleotide exchange factor SEC7", "refseq_ac": "NP_010454", "gene_names_uniprotkb": "SEC7; YD9395.01C; YD9489.05C", "gene_names_refseq": "SEC7", "protein_names_uniprotkb": "ADP-ribosylation factor guanine nucleotide-exchange factor SEC7; ARF-GEP SEC7", "protein_names_refseq": "Arf family guanine nucleotide exchange factor SEC7", "tax_id": 559292, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (sce:YDR170C)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "11208097;14562106;14690591;15665377;1729652;17330950;17563356;18407956;18832381;19684113;19779198;19795423;19823750;1986005;20702584;21126336;21177495;22106047;22118465;22218487;22516198;23749301;24374639;24613384;25220393;26360031;2684655;29514977;3042778;30516470;32597660;33481703;33491328;9169867;9473503", "class_list": "", "function": "Guanine exchange factor that acts as an activator of ARF1 at the trans-Golgi network and is thus involved in vesicular budding and traffic between compartments of the Golgi apparatus (PubMed:11208097, PubMed:1729652, PubMed:1986005, PubMed:22516198, PubMed:24613384, PubMed:26360031, PubMed:2684655, PubMed:29514977, PubMed:3042778). Activation of Arf (ADP-ribosylation factor) GTPases is essential for vesicle formation via recruitment of cargo adapters and coat proteins necessary for Golgi trafficking (PubMed:26360031). Also plays an essential role in ER-to-Golgi traffic (PubMed:9473503). SEC7 also acts as an effector of two Rab GTPases, YPT1 and YPT31/32 (PubMed:25220393)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 68, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSF1;Q03960;Q04139", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol;GO:0012507 ER to Golgi transport vesicle membrane;GO:0005770 late endosome", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P11075-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11076-1", "uniprot_id": "ARF1_YEAST", "mass": 20529.0, "length": 181, "protein_name": "ADP-ribosylation factor 1", "gene_name": "ARF1", "organism": "Yeast", "refseq_name": "Arf family GTPase ARF1", "refseq_ac": "NP_010089", "gene_names_uniprotkb": "ARF1; D1244", "gene_names_refseq": "ARF1", "protein_names_uniprotkb": "ADP-ribosylation factor 1; 3.6.5.2", "protein_names_refseq": "Arf family GTPase ARF1", "tax_id": 559292, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (sce:YDL192W); (R-SCE-1660499); (R-SCE-1660514); (R-SCE-199992); (R-SCE-5620916); (R-SCE-6807878); (R-SCE-6811434); (R-SCE-6811438)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "10601336;14562106;15356266;15504911;16956384;19141284;20601958;20702584;22106047;22304919;24374639;3133654;32597660;33491328;34830155;8896272;9169867", "class_list": "", "function": "GTP-binding protein involved in Golgi vesicle trafficking (PubMed:15356266, PubMed:34830155). May modulate vesicle budding and uncoating within the Golgi apparatus (PubMed:15356266). May recruit the lipid transfer protein VPS13 to Golgi membranes (PubMed:34830155). Recruits polyadenylate-binding protein PAB1 to COPI vesicles, and this is required for correct localization of the asymmetrically distributed ASH1 mRNA (PubMed:15356266)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRG1", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.1.3.1;3.1.3.54;3.1.7.6;3.6.5.4;3.6.5.5;2.3.1.-;2.7.1.67", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0019217 regulation of fatty acid metabolic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P11076-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11154-1", "uniprot_id": "PYC1_YEAST", "mass": 130099.0, "length": 1178, "protein_name": "Pyruvate carboxylase 1", "gene_name": "PYC1", "organism": "Yeast", "refseq_name": "pyruvate carboxylase 1", "refseq_ac": "NP_011453", "gene_names_uniprotkb": "PYC1; PYV", "gene_names_refseq": "PYC1", "protein_names_uniprotkb": "Pyruvate carboxylase 1; 6.4.1.1; PCB 1; Pyruvic carboxylase 1", "protein_names_refseq": "pyruvate carboxylase 1", "tax_id": 559292, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); pyruvate carboxylase deficiency disease (Disease Ontology:DOID:3651)", "pathway": " (sce:YGL062W); (R-SCE-196780); (R-SCE-70263); (R-SCE-70268)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "14562106;24374639;3036126;3042770;32597660;33491328;9169869;9234674", "class_list": "", "function": "Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VU79", "ec_number_list": "6.4.1.1;6.3.4.-;6.3.4.10;6.3.4.11;6.3.4.15;6.3.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004736 pyruvate carboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11154-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11325-1", "uniprot_id": "SYLM_YEAST", "mass": 101920.0, "length": 894, "protein_name": "Leucine--tRNA ligase, mitochondrial", "gene_name": "NAM2", "organism": "Yeast", "refseq_name": "leucine--tRNA ligase NAM2", "refseq_ac": "NP_013486", "gene_names_uniprotkb": "NAM2; L3502.6; MSL1", "gene_names_refseq": "MSL1; NAM2", "protein_names_uniprotkb": "Leucine--tRNA ligase, mitochondrial; 6.1.1.4; LeuRS; Leucyl-tRNA synthetase", "protein_names_refseq": "leucine--tRNA ligase NAM2", "tax_id": 559292, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YLR382C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;1990003;24374639;2826465;3034607;33491328;9169871", "class_list": "", "function": "Catalyzes the attachment of leucine to tRNA(Leu) in the mitochondrion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ17", "ec_number_list": "6.1.1.4", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004823 leucine-tRNA ligase activity;GO:0097157 pre-mRNA intronic binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006429 leucyl-tRNA aminoacylation;GO:0006397 mRNA processing;GO:0032543 mitochondrial translation;GO:0000372 Group I intron splicing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P11325-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11353-1", "uniprot_id": "HEM6_YEAST", "mass": 37712.0, "length": 328, "protein_name": "Oxygen-dependent coproporphyrinogen-III oxidase", "gene_name": "HEM13", "organism": "Yeast", "refseq_name": "coproporphyrinogen oxidase", "refseq_ac": "NP_010329", "gene_names_uniprotkb": "HEM13; YD5112.02", "gene_names_refseq": "HEM13", "protein_names_uniprotkb": "Oxygen-dependent coproporphyrinogen-III oxidase; 1.3.3.3; COX; Coprogen oxidase; Coproporphyrinogenase", "protein_names_refseq": "coproporphyrinogen oxidase", "tax_id": 559292, "disease": "hereditary coproporphyria (Disease Ontology:DOID:13269); liver disease (Disease Ontology:DOID:409)", "pathway": " (sce:YDR044W); (R-SCE-189451)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562095;14562106;15194705;17322287;19779198;22814378;24374639;2838478;3516695;9169867", "class_list": "", "function": "Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS32", "ec_number_list": "1.3.3.3", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004109 coproporphyrinogen oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11412-1", "uniprot_id": "G6PD_YEAST", "mass": 57522.0, "length": 505, "protein_name": "Glucose-6-phosphate 1-dehydrogenase", "gene_name": "ZWF1", "organism": "Yeast", "refseq_name": "glucose-6-phosphate dehydrogenase", "refseq_ac": "NP_014158", "gene_names_uniprotkb": "ZWF1; MET19; N1110", "gene_names_refseq": "MET19; POS10; ZWF1", "protein_names_uniprotkb": "Glucose-6-phosphate 1-dehydrogenase; 1.1.1.49; G6PD", "protein_names_refseq": "glucose-6-phosphate dehydrogenase", "tax_id": 559292, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nonspherocytic hemolytic anemia 1 (Disease Ontology:DOID:0051003); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); malaria (Disease Ontology:DOID:12365); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); favism (Disease Ontology:DOID:13628); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); renovascular hypertension (Disease Ontology:DOID:1591); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); neonatal jaundice (Disease Ontology:DOID:2383); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); kidney disease (Disease Ontology:DOID:557); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); hyperhomocysteinemia (Disease Ontology:DOID:9279); phenylketonuria (Disease Ontology:DOID:9281); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YNL241C); (R-SCE-5628897); (R-SCE-71336)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "14562106;17322287;17330950;2001672;20371607;2040308;2269430;2387402;24374639;30240188;33481703;33491328;3922403;8896273;9169873", "class_list": "", "function": "Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0V2;E9P908", "ec_number_list": "1.1.1.49", "go_molecular_function": "GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042542 response to hydrogen peroxide;GO:0009051 pentose-phosphate shunt, oxidative branch;GO:0006006 glucose metabolic process;GO:0006740 NADPH regeneration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P11412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11433-1", "uniprot_id": "CDC24_YEAST", "mass": 96940.0, "length": 854, "protein_name": "Cell division control protein 24", "gene_name": "CDC24", "organism": "Yeast", "refseq_name": "Rho family guanine nucleotide exchange factor CDC24", "refseq_ac": "NP_009359", "gene_names_uniprotkb": "CDC24; CLS4", "gene_names_refseq": "CDC24; CLS4", "protein_names_uniprotkb": "Cell division control protein 24; Calcium regulatory protein", "protein_names_refseq": "Rho family guanine nucleotide exchange factor CDC24", "tax_id": 559292, "disease": "cataract 48 (Disease Ontology:DOID:0070354); neurodevelopmental disorder with language delay and seizures (Disease Ontology:DOID:0070444); cerebral atherosclerosis (Disease Ontology:DOID:12720); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (sce:YAL041W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "14562106;17287358;17330950;17460121;1755844;17563356;18407956;19668330;19779198;19782078;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;24909858;32597660;3301539;33229814;33481703;33491328;7731988", "class_list": "", "function": "Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 49, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH5", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0000935 division septum;GO:0120171 Cdc24p-Far1p-Gbetagamma complex", "go_biological_process": "GO:0072697 protein localization to cell cortex;GO:0035556 intracellular signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0007096 regulation of exit from mitosis;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P11433-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11484-1", "uniprot_id": "SSB1_YEAST", "mass": 66602.0, "length": 613, "protein_name": "Ribosome-associated molecular chaperone SSB1", "gene_name": "SSB1", "organism": "Yeast", "refseq_name": "Hsp70 family ATPase SSB1", "refseq_ac": "NP_010052", "gene_names_uniprotkb": "SSB1; YG101", "gene_names_refseq": "SSB1; YG101", "protein_names_uniprotkb": "Ribosome-associated molecular chaperone SSB1; 3.6.4.10; Cold-inducible protein YG101; Heat shock protein SSB1; Hsp70 chaperone Ssb", "protein_names_refseq": "Hsp70 family ATPase SSB1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL229W); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 7, "publication_count": 40, "publication_id_list": "10322015;10347213;11739779;11929994;1394434;14562106;15665377;16219770;16221677;17132105;17287358;17330950;17563356;18086883;18407956;19779198;20702584;21126336;23332755;23749301;24374639;2651414;2661019;2664714;27882919;27917864;30516470;32597660;3302682;33481703;33491328;6761581;7646503;7737086;7895733;8994035;9169867;9298649;9670014;9860955", "class_list": "", "function": "Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRC7;E9P9V5;Q05834", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.3.1.286;2.4.1.1;5.6.2.3;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;3.6.-.-;5.6.2.4;5.2.1.8;1.11.1.6;3.5.4.6;3.6.4.-;2.7.1.11;5.6.1.4;2.7.1.2;1.1.1.42;3.6.4.12;3.4.25.1;3.6.4.6;5.6.2.5;3.6.5.-;2.7.11.24;3.6.1.-;2.3.2.27;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;3.1.-.-;3.4.24.-;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;2.7.4.3;2.7.11.1;2.1.1.-;7.2.2.-", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0006415 translational termination;GO:0000054 ribosomal subunit export from nucleus;GO:0006364 rRNA processing;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P11484-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11491-1", "uniprot_id": "PPB_YEAST", "mass": 63004.0, "length": 566, "protein_name": "Repressible alkaline phosphatase", "gene_name": "PHO8", "organism": "Yeast", "refseq_name": "alkaline phosphatase PHO8", "refseq_ac": "NP_010769", "gene_names_uniprotkb": "PHO8; D8035.24", "gene_names_refseq": "PHO8", "protein_names_uniprotkb": "Repressible alkaline phosphatase; 3.1.3.1; 3.1.3.54; Farnesyl diphosphatase; Fructose-2,6-bisphosphate 6-phosphatase; Membrane-bound repressible alkaline phosphatase", "protein_names_refseq": "alkaline phosphatase PHO8", "tax_id": 559292, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); bone disease (Disease Ontology:DOID:0080001); adult hypophosphatasia (Disease Ontology:DOID:0110913); infantile hypophosphatasia (Disease Ontology:DOID:0110914); childhood hypophosphatasia (Disease Ontology:DOID:0110915); osteomalacia (Disease Ontology:DOID:10573); rickets (Disease Ontology:DOID:10609); cryptorchidism (Disease Ontology:DOID:11383); primary biliary cholangitis (Disease Ontology:DOID:12236); familial combined hyperlipidemia (Disease Ontology:DOID:13809); cleidocranial dysplasia (Disease Ontology:DOID:13994); hypophosphatasia (Disease Ontology:DOID:14213); calcinosis (Disease Ontology:DOID:182); arteriosclerosis (Disease Ontology:DOID:2349); germ cell cancer (Disease Ontology:DOID:2994); carcinoma (Disease Ontology:DOID:305); gonadoblastoma (Disease Ontology:DOID:3301); germinoma (Disease Ontology:DOID:3304); embryonal carcinoma (Disease Ontology:DOID:3308); osteosarcoma (Disease Ontology:DOID:3347); meningioma (Disease Ontology:DOID:3565); choriocarcinoma (Disease Ontology:DOID:3594); seminoma (Disease Ontology:DOID:4440); uremia (Disease Ontology:DOID:4676); ulcerative colitis (Disease Ontology:DOID:8577); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (sce:YDR481C); (R-SCE-1483166); (R-SCE-163125); (R-SCE-6811438); (R-SCE-8935690)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "14562106;16484724;17322287;17330950;18407956;1848184;19684113;19779198;21177495;22814378;23749301;24374639;2676517;32597660;3319783;33481703;33491328;9169867", "class_list": "", "function": "Phosphatase with broad substrate specificity. A truncated (soluble) version of the protein is responsible for the production of (E,E)-farnesol from (E,E)-farnesyl diphosphate. Acts as a fructose-2,6-bisphosphate 6-phosphatase (PubMed:1848184)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VTA4;E9P949;Q03374", "ec_number_list": "3.1.3.2;3.6.5.2;3.1.3.1;3.1.3.54;3.1.7.6;3.1.3.48;3.4.11.9", "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0046872 metal ion binding;GO:0047386 fructose-2,6-bisphosphate 6-phosphatase activity", "go_cellular_component": "GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0046496 nicotinamide nucleotide metabolic process;GO:0009166 nucleotide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P11491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11632-1", "uniprot_id": "NHP6A_YEAST", "mass": 10802.0, "length": 93, "protein_name": "Non-histone chromosomal protein 6A", "gene_name": "NHP6A", "organism": "Yeast", "refseq_name": "high-mobility group nucleosome-binding protein", "refseq_ac": "NP_015377", "gene_names_uniprotkb": "NHP6A; NHPA; YP9499.09C", "gene_names_refseq": "NHP6A", "protein_names_uniprotkb": "Non-histone chromosomal protein 6A", "protein_names_refseq": "high-mobility group nucleosome-binding protein", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); syndromic microphthalmia 13 (Disease Ontology:DOID:0111811); Kawasaki disease (Disease Ontology:DOID:13378); alcohol use disorder (Disease Ontology:DOID:1574); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (sce:YPR052C); (R-SCE-140342); (R-SCE-163282); (R-SCE-5620971); (R-SCE-5686938); (R-SCE-6798695); (R-SCE-9837999)", "pathway_count": 7, "publication_count": 30, "publication_id_list": "10228169;11118215;11239460;11287614;11313475;11422939;11432837;12381320;12952948;1339437;14562106;14585989;14739930;15082784;15504049;15987999;16407207;17322287;21126336;22218487;23749301;2406250;24374639;32597660;33481703;33491328;7721780;8946917;9169875;9468494", "class_list": "", "function": "DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W459", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003676 nucleic acid binding;GO:0031491 nucleosome binding;GO:0032407 MutSalpha complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006325 chromatin organization;GO:0070898 RNA polymerase III preinitiation complex assembly;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P11632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11633-1", "uniprot_id": "NHP6B_YEAST", "mass": 11476.0, "length": 99, "protein_name": "Non-histone chromosomal protein 6B", "gene_name": "NHP6B", "organism": "Yeast", "refseq_name": "high-mobility group nucleosome-binding protein", "refseq_ac": "NP_009647", "gene_names_uniprotkb": "NHP6B; NHPB; YBR090BC", "gene_names_refseq": "NHP6B; YBR090C-A", "protein_names_uniprotkb": "Non-histone chromosomal protein 6B", "protein_names_refseq": "high-mobility group nucleosome-binding protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR089C-A)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11118215;11239460;11287614;11313475;11432837;12952948;14562095;14562106;14585989;16407207;17244705;17322287;21126336;22814378;2406250;24374639;33481703;33491328;7721780;7813418;7900426;8946917", "class_list": "", "function": "DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6A., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBM2;D6VQ90;P89500;P89501", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006366 transcription by RNA polymerase II;GO:0070898 RNA polymerase III preinitiation complex assembly;GO:0001195 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P11633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11655-1", "uniprot_id": "SEC12_YEAST", "mass": 51608.0, "length": 471, "protein_name": "Guanine nucleotide-exchange factor SEC12", "gene_name": "SEC12", "organism": "Yeast", "refseq_name": "Sar family guanine nucleotide exchange factor SEC12", "refseq_ac": "NP_014423", "gene_names_uniprotkb": "SEC12; N3244; SED2", "gene_names_refseq": "SEC12; SED2", "protein_names_uniprotkb": "Guanine nucleotide-exchange factor SEC12; Protein transport protein SEC12", "protein_names_refseq": "Sar family guanine nucleotide exchange factor SEC12", "tax_id": 559292, "disease": "cranioectodermal dysplasia (Disease Ontology:DOID:0050577); autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (sce:YNR026C); (R-SCE-204005)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10189369;11694599;12163183;12655150;1327759;14562095;14562106;16413259;1649197;1907973;1907974;1922074;24374639;2512296;3047151;6996832;7865879;8106544;8367481;8377826;8583945;8589449;8707815;9023343;9152025;9169873;9275186", "class_list": "", "function": "Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W1K0", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0003400 regulation of COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P11655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11709-1", "uniprot_id": "BIK1_YEAST", "mass": 51092.0, "length": 440, "protein_name": "Nuclear fusion protein BIK1", "gene_name": "BIK1", "organism": "Yeast", "refseq_name": "Bik1p", "refseq_ac": "NP_009901", "gene_names_uniprotkb": "BIK1; YCL29C", "gene_names_refseq": "ARM5; BIK1; PAC14", "protein_names_uniprotkb": "Nuclear fusion protein BIK1", "protein_names_refseq": "Bik1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL029C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562106;1574125;17330950;18407956;1897318;19684113;19779198;19795423;19823750;20702584;21126336;21177495;2277073;23749301;24374639;30516470;32597660;3302672;33481703;33491328", "class_list": "", "function": "Required for nuclear fusion, chromosome disjunction, and nuclear segregation during mitosis. Probably required for the formation or stabilization of microtubules during mitosis and for spindle pole body fusion during conjugation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQY6", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005819 spindle;GO:0005938 cell cortex;GO:0005875 microtubule associated complex;GO:0000776 kinetochore", "go_biological_process": "GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0000132 establishment of mitotic spindle orientation;GO:0000819 sister chromatid segregation;GO:0031115 negative regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P11709-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11710-1", "uniprot_id": "FUS1_YEAST", "mass": 57779.0, "length": 512, "protein_name": "Nuclear fusion protein FUS1", "gene_name": "FUS1", "organism": "Yeast", "refseq_name": "Fus1p", "refseq_ac": "NP_009903", "gene_names_uniprotkb": "FUS1; YCL27W", "gene_names_refseq": "FUS1", "protein_names_uniprotkb": "Nuclear fusion protein FUS1", "protein_names_refseq": "Fus1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL027W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15020407;1574125;17330950;24374639;2690078;3302672;3313002;33229814;33481703;33491328", "class_list": "", "function": "Interacts with SHO1., [UniProtKB, PubMed]; Required for cell fusion. Negatively regulates Sho1p signaling to ensure efficient cell fusion., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VQY8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0043332 mating projection tip", "go_biological_process": "GO:0032065 maintenance of protein location in cell cortex;GO:0000755 cytogamy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P11710-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11745-1", "uniprot_id": "RNA1_YEAST", "mass": 45816.0, "length": 407, "protein_name": "Ran GTPase-activating protein 1", "gene_name": "RNA1", "organism": "Yeast", "refseq_name": "GTPase-activating protein RNA1", "refseq_ac": "NP_013962", "gene_names_uniprotkb": "RNA1; YM9959.17C", "gene_names_refseq": "RNA1", "protein_names_uniprotkb": "Ran GTPase-activating protein 1; Protein involved in RNA production/processing", "protein_names_refseq": "GTPase-activating protein RNA1", "tax_id": 559292, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (sce:YMR235C); (R-SCE-9615933); (R-SCE-9793242)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "14562106;1603072;17330950;19779198;19795423;19823750;21177495;24374639;2674676;33481703;33491328;9169872", "class_list": "", "function": "GTPase activator for the nuclear Ras-related regulatory protein GSP1 (Ran), converting it to the putatively inactive GDP-bound state., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W061", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006409 tRNA export from nucleus;GO:0000054 ribosomal subunit export from nucleus;GO:0051168 nuclear export;GO:0006404 RNA import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P11745-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11746-1", "uniprot_id": "MCM1_YEAST", "mass": 32802.0, "length": 286, "protein_name": "Pheromone receptor transcription factor", "gene_name": "MCM1", "organism": "Yeast", "refseq_name": "transcription factor MCM1", "refseq_ac": "NP_013757", "gene_names_uniprotkb": "MCM1; FUN80; YM9532.08", "gene_names_refseq": "FUN80; MCM1", "protein_names_uniprotkb": "Pheromone receptor transcription factor; GRM/PRTF protein", "protein_names_refseq": "transcription factor MCM1", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YMR043W); (R-SCE-9031628)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10632874;12464633;14562106;17322287;1756728;18407956;19779198;19795423;19823750;20702584;21126336;2159934;22218487;22814378;24374639;3066908;32597660;3311883;33481703;33491328;8628280;9001236;9169872;9490409", "class_list": "", "function": "Transcription factor required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes. Activates transcription of ECB-dependent genes during the G1/M phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Interacts with the alpha-2 repressor or with the alpha-1 activator thereby regulating the expression of mating-type-specific genes. With ARG80, ARG81 and ARG82, coordinates the expression of arginine anabolic and catabolic genes in response to arginine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZL8", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0044377 RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006525 arginine metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P11746-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11747-1", "uniprot_id": "TAF13_YEAST", "mass": 19132.0, "length": 167, "protein_name": "Transcription initiation factor TFIID subunit 13", "gene_name": "TAF13", "organism": "Yeast", "refseq_name": "Taf13p", "refseq_ac": "NP_013611", "gene_names_uniprotkb": "TAF13; FUN81; TAF19", "gene_names_refseq": "FUN81; TAF13; TAF19", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 13; Function unknown 81 protein; TAFII-19; TAFII19; TBP-associated factor 13; TBP-associated factor 19 kDa", "protein_names_refseq": "Taf13p", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder 60 (Disease Ontology:DOID:0081222)", "pathway": " (sce:YML098W); (R-SCE-674695); (R-SCE-6807505); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10788514;11295558;12093743;12138208;12516863;14562095;14562106;17322287;17563356;19779198;20702584;23749301;24374639;3311883;33481703;33491328;9169872;9695952", "class_list": "", "function": "Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0I7", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P11747-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11792-1", "uniprot_id": "SCH9_YEAST", "mass": 91812.0, "length": 824, "protein_name": "Serine/threonine-protein kinase SCH9", "gene_name": "SCH9", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase SCH9", "refseq_ac": "NP_012075", "gene_names_uniprotkb": "SCH9; KOM1", "gene_names_refseq": "HRM2; KOM1; SCH9", "protein_names_uniprotkb": "Serine/threonine-protein kinase SCH9; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase SCH9", "tax_id": 559292, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Cowden syndrome 6 (Disease Ontology:DOID:0081002); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypoinsulinemic hypoglycemia with hemihypertrophy (Disease Ontology:DOID:0112263); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); esophageal carcinoma (Disease Ontology:DOID:1107); polycystic ovary syndrome (Disease Ontology:DOID:11612); alcoholic hepatitis (Disease Ontology:DOID:12351); vulva cancer (Disease Ontology:DOID:1245); Proteus syndrome (Disease Ontology:DOID:13482); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); opiate dependence (Disease Ontology:DOID:2559); pulmonary tuberculosis (Disease Ontology:DOID:2957); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); esophageal cancer (Disease Ontology:DOID:5041); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); paraplegia (Disease Ontology:DOID:607); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YHR205W); (R-SCE-1257604); (R-SCE-1474151); (R-SCE-165158); (R-SCE-198323); (R-SCE-198693); (R-SCE-203615); (R-SCE-389357); (R-SCE-389513); (R-SCE-392451); (R-SCE-450385); (R-SCE-5218920); (R-SCE-6804757); (R-SCE-6804758); (R-SCE-6811558); (R-SCE-8948751); (R-SCE-9009391); (R-SCE-9031628); (R-SCE-9841251); (R-SCE-9856530)", "pathway_count": 20, "publication_count": 37, "publication_id_list": "10074427;14562106;15470109;15665377;17287358;17330950;17560372;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21177495;21531713;21841122;22218487;22319457;23749301;24374639;27821475;28143980;28483912;29038496;29698392;32318242;32597660;32801125;3290050;33157024;33481703;33491328;35166010;8091229;8442384", "class_list": "", "function": "Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity (PubMed:20702584). Regulates ribosome biogenesis, translation initiation, and entry into stationary phase in a TORC1-dependent manner (PubMed:17560372)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLF4", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;1.6.2.4;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.16;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;2.3.1.48;3.6.-.-;2.3.1.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0032880 regulation of protein localization;GO:0034599 cellular response to oxidative stress;GO:0045945 positive regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P11792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11914-1", "uniprot_id": "MPPA_YEAST", "mass": 53338.0, "length": 482, "protein_name": "Mitochondrial-processing peptidase subunit alpha", "gene_name": "MAS2", "organism": "Yeast", "refseq_name": "mitochondrial-processing protease subunit alpha", "refseq_ac": "NP_011889", "gene_names_uniprotkb": "MAS2; MIF2", "gene_names_refseq": "MAS2; MIF2", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit alpha; Alpha-MPP; Inactive zinc metalloprotease alpha; MPP; Matrix processing peptidase; Mitochondrial assembly protein 2; Mitochondrial import function protein 2", "protein_names_refseq": "mitochondrial-processing protease subunit alpha", "tax_id": 559292, "disease": "autosomal recessive spinocerebellar ataxia 2 (Disease Ontology:DOID:0080061)", "pathway": " (sce:YHR024C); (R-SCE-611105); (R-SCE-9837999)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11470436;14562106;18407956;2007593;23749301;24374639;3061797;3061808;33491328;8091229;9299349", "class_list": "", "function": "Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKX1", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0017087 mitochondrial processing peptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006627 protein processing involved in protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P11914-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11938-1", "uniprot_id": "RAP1_YEAST", "mass": 92413.0, "length": 827, "protein_name": "DNA-binding protein RAP1", "gene_name": "RAP1", "organism": "Yeast", "refseq_name": "DNA-binding transcription factor RAP1", "refseq_ac": "NP_014183", "gene_names_uniprotkb": "RAP1; GRF1; N1310; TUF1", "gene_names_refseq": "GRC4; GRF1; RAP1; TBA1; TUF1", "protein_names_uniprotkb": "DNA-binding protein RAP1; Repressor/activator site-binding protein; SBF-E; TUF", "protein_names_refseq": "DNA-binding transcription factor RAP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL216W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562106;15616568;17330950;17563356;18407956;19779198;21126336;23749301;24374639;28575419;32597660;3315231;33481703;33491328;7762305;7867933;8194531;8508768;8620531;9169873", "class_list": "", "function": "Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres (PubMed:3315231, PubMed:8194531). RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences (PubMed:3315231, PubMed:8194531). The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers (PubMed:7867933, PubMed:8508768). RAP1 mediates repression of the HM loci and telomeres by recruiting the SIR complex (PubMed:7867933). May also target the binding of RIF1 and RIF2 to silencers and telomeres (PubMed:7867933). Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene (PubMed:8508768)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0X4", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003700 DNA-binding transcription factor activity;GO:0042162 telomeric DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070187 shelterin complex;GO:0032993 protein-DNA complex;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006110 regulation of glycolytic process;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P11938-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11972-1", "uniprot_id": "SST2_YEAST", "mass": 79716.0, "length": 698, "protein_name": "Protein SST2", "gene_name": "SST2", "organism": "Yeast", "refseq_name": "GTPase-activating protein SST2", "refseq_ac": "NP_013557", "gene_names_uniprotkb": "SST2; L9324.9", "gene_names_refseq": "SSL2; SST2", "protein_names_uniprotkb": "Protein SST2", "protein_names_refseq": "GTPase-activating protein SST2", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); glomerulosclerosis (Disease Ontology:DOID:0050851); hypertension (Disease Ontology:DOID:10763); opioid abuse (Disease Ontology:DOID:11206); lesion of sciatic nerve (Disease Ontology:DOID:12528); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); bladder disease (Disease Ontology:DOID:365); liver cirrhosis (Disease Ontology:DOID:5082); female stress incontinence (Disease Ontology:DOID:724)", "pathway": " (sce:YLR452C); (R-SCE-418594)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10593933;11875433;14562106;14690591;15665377;15924435;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;23749301;24374639;2830483;32597660;33481703;33491328;9169871", "class_list": "", "function": "Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ86;Q06207", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0071444 cellular response to pheromone;GO:0000747 conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P11972-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11978-1", "uniprot_id": "SIR4_YEAST", "mass": 152062.0, "length": 1358, "protein_name": "Regulatory protein SIR4", "gene_name": "SIR4", "organism": "Yeast", "refseq_name": "chromatin-silencing protein SIR4", "refseq_ac": "NP_010513", "gene_names_uniprotkb": "SIR4; ASD1; STE9; UTH2; YD9934.12", "gene_names_refseq": "ASD1; SIR4; STE9; UTH2", "protein_names_uniprotkb": "Regulatory protein SIR4; Silent information regulator 4", "protein_names_refseq": "chromatin-silencing protein SIR4", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR227W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10490600;11722841;12791253;14551211;15542864;17287358;17330950;17563356;18039933;18407956;19520826;19779198;19795423;19823750;20190278;21177495;22654676;22814378;23749301;24374639;26149687;32597660;33229814;3325825;33481703;33491328;33502312;7867933;7885847;9169867;9271422", "class_list": "", "function": "The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR (PubMed:18039933). The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure (PubMed:18039933). Involves the compaction of chromatin fiber into a more condensed form (PubMed:18039933)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 49, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6VSK9", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003690 double-stranded DNA binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005677 chromatin silencing complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0097695 establishment of protein-containing complex localization to telomere;GO:0031453 positive regulation of heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P11978-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12383-1", "uniprot_id": "PDR1_YEAST", "mass": 121794.0, "length": 1068, "protein_name": "Transcription factor PDR1", "gene_name": "PDR1", "organism": "Yeast", "refseq_name": "drug-responsive transcription factor PDR1", "refseq_ac": "NP_011502", "gene_names_uniprotkb": "PDR1; AMY1; ANT1; BOR2; CYH3; NRA2; SMR2; TIL1; TPE1; TPE3", "gene_names_refseq": "AMY1; ANT1; BOR2; CYH3; NRA2; PDR1; SMR2; TIL1; TPE1; TPE3", "protein_names_uniprotkb": "Transcription factor PDR1; Pleiotropic drug resistance protein 1", "protein_names_refseq": "drug-responsive transcription factor PDR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL013C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;15665377;17330950;17563356;18407956;1882553;19779198;20702584;23749301;24374639;27618436;32597660;3316228;33481703;33491328;9169869", "class_list": "", "function": "Positive regulator of proteins involved in permeability. PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUC4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071466 cellular response to xenobiotic stimulus;GO:2001040 positive regulation of cellular response to drug", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P12383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12385-1", "uniprot_id": "ERF1_YEAST", "mass": 49006.0, "length": 437, "protein_name": "Eukaryotic peptide chain release factor subunit 1", "gene_name": "SUP45", "organism": "Yeast", "refseq_name": "translation termination factor eRF1", "refseq_ac": "NP_009701", "gene_names_uniprotkb": "SUP45; SAL4; SUP1; YBR1120", "gene_names_refseq": "SAL4; SUP1; SUP45; SUP47", "protein_names_uniprotkb": "Eukaryotic peptide chain release factor subunit 1; Eukaryotic release factor 1; Omnipotent suppressor protein 1; eRF1", "protein_names_refseq": "translation termination factor eRF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR143C); (R-SCE-72764); (R-SCE-975956); (R-SCE-975957)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "14562095;14562106;15509572;16321977;16809762;19779198;19795423;19823750;20947765;21126336;21177495;22106047;23749301;24374639;3037308;33229814;33481703;33491328;34413231;3526282;7556078;7813418;8109177", "class_list": "", "function": "Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:20947765, PubMed:34413231, PubMed:7556078). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:20947765, PubMed:7556078). SUP45/eRF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:20947765, PubMed:34413231, PubMed:7556078). Following GTP hydrolysis by SUP35/eRF3, SUP35/eRF3 dissociates, permitting SUP45/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:20947765, PubMed:34413231, PubMed:7556078)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VQD9", "ec_number_list": "", "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity;GO:1990825 sequence-specific mRNA binding;GO:0003747 translation release factor activity;GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0018444 translation release factor complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0002184 cytoplasmic translational termination;GO:0006415 translational termination;GO:0006353 DNA-templated transcription termination;GO:0009302 sno(s)RNA transcription", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P12385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12611-1", "uniprot_id": "WHI2_YEAST", "mass": 55346.0, "length": 486, "protein_name": "Growth regulation protein", "gene_name": "WHI2", "organism": "Yeast", "refseq_name": "Whi2p", "refseq_ac": "NP_014686", "gene_names_uniprotkb": "WHI2", "gene_names_refseq": "WHI2", "protein_names_uniprotkb": "Growth regulation protein", "protein_names_refseq": "Whi2p", "tax_id": 559292, "disease": "progressive myoclonus epilepsy 3 (Disease Ontology:DOID:0111446)", "pathway": " (sce:YOR043W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12090248;14562106;17287358;17563356;18407956;23749301;24374639;3049245;32597660;33229814;33481703;33491328;34965436;9169874", "class_list": "", "function": "Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W2A9;Q08413", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071944 cell periphery;GO:1903293 phosphatase complex", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P12611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12630-1", "uniprot_id": "BAR1_YEAST", "mass": 63730.0, "length": 587, "protein_name": "Barrierpepsin", "gene_name": "BAR1", "organism": "Yeast", "refseq_name": "aspartyl protease BAR1", "refseq_ac": "NP_012249", "gene_names_uniprotkb": "BAR1; SST1", "gene_names_refseq": "BAR1; SST1", "protein_names_uniprotkb": "Barrierpepsin; 3.4.23.35; BAR proteinase; Extracellular 'barrier' protein", "protein_names_refseq": "aspartyl protease BAR1", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (sce:YIL015W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;24374639;3124102;9169870", "class_list": "", "function": "This protein called 'barrier activity' is excreted by yeast cells mating type a. It is probably a protease that cleaves alpha-factor and thus acts as an antagonist of this mating pheromone and establishes optimal pheromone concentration for conjugation., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6VVR4", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0071944 cell periphery;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0016485 protein processing;GO:0043171 peptide catabolic process;GO:0071444 cellular response to pheromone;GO:0000747 conjugation with cellular fusion;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P12630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12683-1", "uniprot_id": "HMDH1_YEAST", "mass": 115626.0, "length": 1054, "protein_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase 1", "gene_name": "HMG1", "organism": "Yeast", "refseq_name": "hydroxymethylglutaryl-CoA reductase (NADPH) HMG1", "refseq_ac": "NP_013636", "gene_names_uniprotkb": "HMG1", "gene_names_refseq": "HMG1", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-coenzyme A reductase 1; 1.1.1.34; HMG-CoA reductase 1", "protein_names_refseq": "hydroxymethylglutaryl-CoA reductase (NADPH) HMG1", "tax_id": 559292, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive limb-girdle muscular dystrophy type 28 (Disease Ontology:DOID:0061130); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); drug-induced hepatitis (Disease Ontology:DOID:2044); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myopathy (Disease Ontology:DOID:423); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); Wilson disease (Disease Ontology:DOID:893); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YML075C); (R-SCE-9969896)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "14562095;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;23749301;24374639;3065625;32597660;32679672;33481703;33491328;3526336;8744950;9169872", "class_list": "", "function": "HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway constitutes by the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:3065625, PubMed:3526336). HMG1 and HMG2 catalyze the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate that is the rate-limiting step within the first mosule (PubMed:3526336). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W0K8", "ec_number_list": "1.1.1.34", "go_molecular_function": "GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0034399 nuclear periphery", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0015936 coenzyme A metabolic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P12683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12684-1", "uniprot_id": "HMDH2_YEAST", "mass": 115692.0, "length": 1045, "protein_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase 2", "gene_name": "HMG2", "organism": "Yeast", "refseq_name": "hydroxymethylglutaryl-CoA reductase (NADPH) HMG2", "refseq_ac": "NP_013555", "gene_names_uniprotkb": "HMG2; L9324.2", "gene_names_refseq": "HMG2", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-coenzyme A reductase 2; 1.1.1.34; HMG-CoA reductase 2", "protein_names_refseq": "hydroxymethylglutaryl-CoA reductase (NADPH) HMG2", "tax_id": 559292, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive limb-girdle muscular dystrophy type 28 (Disease Ontology:DOID:0061130); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); drug-induced hepatitis (Disease Ontology:DOID:2044); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myopathy (Disease Ontology:DOID:423); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); Wilson disease (Disease Ontology:DOID:893); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YLR450W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562095;14562106;16847258;17322287;17330950;18407956;21126336;21628456;23749301;24374639;3065625;32597660;32679672;33481703;33491328;3526336;8744950;9169871", "class_list": "", "function": "HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway constitutes by the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:3065625, PubMed:3526336). HMG1 and HMG2 catalyze the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate that is the rate-limiting step within the first mosule (PubMed:3526336). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ84;E9P8X3", "ec_number_list": "1.1.1.34", "go_molecular_function": "GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000502 proteasome complex", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0015936 coenzyme A metabolic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P12684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12688-1", "uniprot_id": "YPK1_YEAST", "mass": 76480.0, "length": 680, "protein_name": "Serine/threonine-protein kinase YPK1", "gene_name": "YPK1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase YPK1", "refseq_ac": "NP_012796", "gene_names_uniprotkb": "YPK1; SLI2", "gene_names_refseq": "SLI2; YPK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase YPK1; 2.7.11.1; Sphingosine-like immunosuppressant resistant protein 2; Yeast protein kinase 1", "protein_names_refseq": "serine/threonine protein kinase YPK1", "tax_id": 559292, "disease": "hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); granulosa cell tumor (Disease Ontology:DOID:2999); serous cystadenocarcinoma (Disease Ontology:DOID:3114); mucinous cystadenocarcinoma (Disease Ontology:DOID:3603)", "pathway": " (sce:YKL126W); (R-SCE-1257604); (R-SCE-1474151); (R-SCE-198323); (R-SCE-198693); (R-SCE-203615); (R-SCE-389357); (R-SCE-389513); (R-SCE-392451); (R-SCE-450385); (R-SCE-5218920); (R-SCE-6804757); (R-SCE-6804758); (R-SCE-6811558); (R-SCE-8948751); (R-SCE-9009391); (R-SCE-9031628); (R-SCE-9841251); (R-SCE-9856530)", "pathway_count": 19, "publication_count": 45, "publication_id_list": "10074427;10825204;11807089;12221112;14562095;14562106;15025559;15470109;15665377;15820214;15840588;17287358;17330950;17563356;18407956;19684113;19779198;19966303;20489023;20702584;21126336;21177495;21841122;22080611;22307609;23749301;24374639;26274562;2850145;28739659;29769614;29986907;30578283;32318242;32597660;32611771;32614710;33481703;33491328;34492164;34965436;39490931;7489717;8196765;8437590", "class_list": "", "function": "Plays an essential role in the proliferation of yeast cells (PubMed:8437590). Involved in a signaling pathway, required for optimal cell wall integrity, that acts in parallel with the PKC1-SLT2-dependent pathway (PubMed:12221112). Downstream kinase in the sphingolipid-mediated signaling pathway (PubMed:10825204, PubMed:34492164, PubMed:39490931). Phosphorylation is regulated by the intracellular sphingolipid concentration (PubMed:34492164). Disruption or inhibition of sphingolipid synthesis leads to the activation and phosphorylation of YPK1 through the TORC2 and PKH1 pathways, which in turn phosphorylates ORM1 and LAG1 to activate sphingolipid synthesis (PubMed:34492164). Cooperates with SLI1 in mediating resistance to the sphingolipid biosynthesis inhibitor drug myriocin (ISP-1); kinase activity is essential for the resistance. Required for both receptor-mediated and fluid-phase endocytosis, but is not necessary for receptor phosphorylation or ubiquitination. Necessary for the internalization of plasma membrane proteins carrying different types of internalization signals. Acts downstream of the PKH kinases to control endocytosis by phosphorylating components of the endocytic machinery (PubMed:39490931). Phosphorylation of residue Thr-504 in the activation loop and residue Thr-662 are essential for activity (PubMed:39490931). Phosphorylates and down-regulates flippase activator FPK1 (PubMed:19966303)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX69", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;1.6.2.4;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.16;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;2.3.1.48;3.6.-.-;2.3.1.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019887 protein kinase regulator activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006897 endocytosis;GO:0035556 intracellular signal transduction;GO:0006665 sphingolipid metabolic process;GO:0090155 negative regulation of sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P12688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12689-1", "uniprot_id": "REV1_YEAST", "mass": 112227.0, "length": 985, "protein_name": "Translesion synthesis protein REV1", "gene_name": "REV1", "organism": "Yeast", "refseq_name": "deoxycytidyl transferase", "refseq_ac": "NP_014991", "gene_names_uniprotkb": "REV1; O6339", "gene_names_refseq": "REV1", "protein_names_uniprotkb": "Translesion synthesis protein REV1; 2.7.7.-; Reversionless protein 1; Template-dependent deoxycytidyl transferase REV1", "protein_names_refseq": "deoxycytidyl transferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR346W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10931348;11316789;14562095;14562106;16195463;16452144;18242152;18275815;18603483;19528320;20388628;21167175;23142547;23240687;23747975;23749301;24049079;24374639;2492497;27001510;33491328;37594077;8751446;8948102;9169874", "class_list": "", "function": "Involved in the translesion DNA synthesis (TLS) branch of the DNA damage tolerance (DDT) pathway, that bypasses replication-blocking lesions without removing them; can play both a catalytic role as a deoxycytidyl transferase and a non-catalytic role as a molecular adapter (PubMed:8751446, PubMed:11316789, PubMed:18603483, PubMed:20388628, PubMed:24049079, PubMed:37594077). Catalyzes the insertion of a dCMP residue opposite a lesion in the template DNA, including at abasic sites and 1,N6-ethenoadenine (PubMed:8751446, PubMed:11316789, PubMed:16195463, PubMed:20388628). Together with DNA polymerase zeta, involved in translesion synthesis at 1,N6-ethenoadenine DNA adducts; the deoxycytidyl transferase catalyzes insertion of cytosine opposite the lesion, followed by extension synthesis by DNA polymerase zeta (PubMed:20388628). REV1 and DNA polymerase zeta are similarly activated when replication forks are stalled at non-canonical hairpin DNA structures; REV1 incorporates a cytosine across from the base of the structure, which triggers a template-switching event that allows for hairpin bypass, but is highly mutagenic due to the use of an ectopic DNA template and the involvement of the low-fidelity DNA polymerase zeta (PubMed:24049079). May also function as a molecular adapter protein at stalled DNA replication forks, that coordinates polymerase recruitment, selection, and switching, in a manner independent of its deoxycytidyl transferase activity (By similarity). Its non-catalytic activity is required to bypass T-T (6-4) UV photoproducts and abasic sites; it also appears to function during endogenous replication stress and when cells are exposed to hydroxyurea (PubMed:10931348, PubMed:23142547, PubMed:37594077). Also functions in the mitochondrion (PubMed:16452144). Not required for the bypass of T-T cyclobutane dimers (PubMed:10931348)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W341;Q12323", "ec_number_list": "", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0060090 molecular adaptor activity;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding;GO:0017125 deoxycytidyl transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis;GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P12689-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12695-1", "uniprot_id": "ODP2_YEAST", "mass": 51818.0, "length": 482, "protein_name": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial", "gene_name": "LAT1", "organism": "Yeast", "refseq_name": "dihydrolipoyllysine-residue acetyltransferase", "refseq_ac": "NP_014328", "gene_names_uniprotkb": "LAT1; N2374; ODP2; PDA2", "gene_names_refseq": "LAT1; ODP2; PDA2", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 2.3.1.12; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2", "protein_names_refseq": "dihydrolipoyllysine-residue acetyltransferase", "tax_id": 559292, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (sce:YNL071W); (R-SCE-9857492); (R-SCE-9861559)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "14562095;14562106;17322287;18407956;19795423;19823750;23749301;24374639;3050999;32597660;33491328;7030741;8701611;9169873", "class_list": "", "function": "The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1A8", "ec_number_list": "1.8.1.4;2.3.1.12;1.2.4.1;6.3.1.20", "go_molecular_function": "GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P12695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12709-1", "uniprot_id": "G6PI_YEAST", "mass": 61299.0, "length": 554, "protein_name": "Glucose-6-phosphate isomerase", "gene_name": "PGI1", "organism": "Yeast", "refseq_name": "glucose-6-phosphate isomerase", "refseq_ac": "NP_009755", "gene_names_uniprotkb": "PGI1; YBR1406", "gene_names_refseq": "CDC30; PGI1", "protein_names_uniprotkb": "Glucose-6-phosphate isomerase; 5.1.3.-; 5.3.1.9; D-hexose-6-phosphate anomerase; GPI; Glucose-6-phosphate C2-epimerase; PGI; PHI; Phosphoglucose isomerase; Phosphohexose isomerase", "protein_names_refseq": "glucose-6-phosphate isomerase", "tax_id": 559292, "disease": "congenital nonspherocytic hemolytic anemia 4 (Disease Ontology:DOID:0051005); intellectual disability (Disease Ontology:DOID:1059); heart disease (Disease Ontology:DOID:114); Parkinson's disease (Disease Ontology:DOID:14330); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); neuromuscular disease (Disease Ontology:DOID:440); congenital hemolytic anemia (Disease Ontology:DOID:589); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YBR196C); (R-SCE-5628897); (R-SCE-6798695); (R-SCE-70171); (R-SCE-70263)", "pathway_count": 5, "publication_count": 27, "publication_id_list": "11283598;14562106;15665377;17287358;1730590;17330950;17563356;18407956;19684113;19779198;19795423;19823750;21126336;23749301;24374639;30240188;3071735;3072254;32597660;33481703;33491328;4570473;6572382;7813418;7975899;8346681;9298649", "class_list": "", "function": "Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:1730590, PubMed:6572382). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (PubMed:1730590, PubMed:4570473, PubMed:6572382)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQJ0", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.1.3.15;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0004347 glucose-6-phosphate isomerase activity;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0097367 carbohydrate derivative binding;GO:0048029 monosaccharide binding;GO:0047938 glucose-6-phosphate 1-epimerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P12709-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12753-1", "uniprot_id": "RAD50_YEAST", "mass": 152569.0, "length": 1312, "protein_name": "DNA repair protein RAD50", "gene_name": "RAD50", "organism": "Yeast", "refseq_name": "MRX complex DNA-binding subunit", "refseq_ac": "NP_014149", "gene_names_uniprotkb": "RAD50; N0872", "gene_names_refseq": "RAD50", "protein_names_uniprotkb": "DNA repair protein RAD50; 153 kDa protein; 3.6.-.-", "protein_names_refseq": "MRX complex DNA-binding subunit", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (sce:YNL250W); (R-SCE-2559586); (R-SCE-5693548); (R-SCE-5693565)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "14562106;18407956;23080121;23749301;24374639;2659437;26896444;27017623;28134932;31537797;33491328;35501303;9169873;9234673;9845372", "class_list": "", "function": "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:26896444, PubMed:28134932). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of TEL1/ATM and ATR upon DNA damage (PubMed:26896444, PubMed:28134932). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (PubMed:26896444). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for the processing of R-loops (PubMed:31537797)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0U3", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;5.6.2.2;3.6.4.12;3.6.4.6;5.6.2.5;3.1.-.-;3.6.1.-;2.3.2.27;2.7.11.1;3.4.24.-;3.6.5.-;2.3.1.48;2.7.4.3;7.2.2.-", "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0030870 Mre11 complex", "go_biological_process": "GO:0006284 base-excision repair;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P12753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12754-1", "uniprot_id": "EI2BD_YEAST", "mass": 70852.0, "length": 651, "protein_name": "Translation initiation factor eIF2B subunit delta", "gene_name": "GCD2", "organism": "Yeast", "refseq_name": "translation initiation factor eIF2B subunit delta", "refseq_ac": "NP_011597", "gene_names_uniprotkb": "GCD2; TIF224", "gene_names_refseq": "GCD12; GCD2", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit delta; GCD complex subunit GCD2; Guanine nucleotide exchange factor subunit GCD2; eIF2B GDP-GTP exchange factor subunit delta", "protein_names_refseq": "translation initiation factor eIF2B subunit delta", "tax_id": 559292, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 4 (Disease Ontology:DOID:0070371)", "pathway": " (sce:YGR083C); (R-SCE-72731)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14562106;21126336;22814378;23749301;24374639;2668117;32597660;33229814;33481703;33491328;8506384;9169869;9472020", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD2 is also required for cell viability. Its function can partially be replaced by GCN3 under normal growth conditions in GCD2-defective mutants, under AA starvation conditions GCN3 is an antagonist (GCN4 translational activator)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VUL5", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P12754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12866-1", "uniprot_id": "STE6_YEAST", "mass": 144766.0, "length": 1290, "protein_name": "Alpha-factor-transporting ATPase", "gene_name": "STE6", "organism": "Yeast", "refseq_name": "ATP-binding cassette a-factor transporter STE6", "refseq_ac": "NP_012713", "gene_names_uniprotkb": "STE6", "gene_names_refseq": "STE6", "protein_names_uniprotkb": "Alpha-factor-transporting ATPase; 7.4.2.7; Mating factor A secretion protein STE6; Multiple drug resistance protein homolog; P-glycoprotein", "protein_names_refseq": "ATP-binding cassette a-factor transporter STE6", "tax_id": 559292, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); familial temporal lobe epilepsy 3 (Disease Ontology:DOID:0060750); progressive familial intrahepatic cholestasis 2 (Disease Ontology:DOID:0070222); progressive familial intrahepatic cholestasis 3 (Disease Ontology:DOID:0070223); intrahepatic cholestasis of pregnancy 3 (Disease Ontology:DOID:0070229); benign recurrent intrahepatic cholestasis 2 (Disease Ontology:DOID:0070232); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); inflammatory bowel disease 13 (Disease Ontology:DOID:0110893); osteonecrosis (Disease Ontology:DOID:10159); antisocial personality disorder (Disease Ontology:DOID:10939); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); malaria (Disease Ontology:DOID:12365); Behcet's disease (Disease Ontology:DOID:13241); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholecystitis (Disease Ontology:DOID:1949); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (sce:YKL209C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12435609;12872131;16847258;1935899;19795423;19823750;23749301;24374639;2569166;2686977;33481703;33491328;3517872;8045256;8196765;8662764", "class_list": "", "function": "STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 53, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ4", "ec_number_list": "7.4.2.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015421 ABC-type oligopeptide transporter activity;GO:0015440 ABC-type peptide transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole;GO:0043332 mating projection tip", "go_biological_process": "GO:0019236 response to pheromone;GO:0090374 oligopeptide export from mitochondrion;GO:0000770 peptide pheromone export", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P12866-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12868-1", "uniprot_id": "PEP5_YEAST", "mass": 117478.0, "length": 1029, "protein_name": "E3 ubiquitin-protein ligase PEP5", "gene_name": "PEP5", "organism": "Yeast", "refseq_name": "tethering complex subunit PEP5", "refseq_ac": "NP_013958", "gene_names_uniprotkb": "PEP5; END1; VAM1; VPL9; VPS11; VPT11; YM9959.13", "gene_names_refseq": "END1; PEP5; VAM1; VPL9; VPS11; VPT11", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PEP5; 2.3.2.27; Carboxypeptidase Y-deficient protein 5; Histone E3 ligase PEP5; RING-type E3 ubiquitin transferase PEP5; Vacuolar biogenesis protein END1; Vacuolar morphogenesis protein 1; Vacuolar protein sorting-associated protein 11; Vacuolar protein-targeting protein 11", "protein_names_refseq": "tethering complex subunit PEP5", "tax_id": 559292, "disease": "hypomyelinating leukoencephalopathy (Disease Ontology:DOID:0050987); hypomyelinating leukodystrophy 12 (Disease Ontology:DOID:0060796); dystonia 32 (Disease Ontology:DOID:0060939); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YMR231W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10944212;10978279;14562106;1526998;16601699;17330950;17488625;17563356;18407956;19779198;2204580;22570702;24374639;2670552;2676511;3062374;320092;32597660;33481703;33491328;3524852;9169872", "class_list": "", "function": "Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. It is required for gluconeogenic growth of yeast. Acts as a component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (PubMed:10944212, PubMed:10978279, PubMed:16601699, PubMed:3062374). Acts as a component of the CORVET complex that is required for transport between endosome and vacuole. CORVET is an effector for the endosomal Rab GTPase VPS21 (PubMed:17488625). Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W057", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0033263 CORVET complex", "go_biological_process": "GO:0048284 organelle fusion;GO:0035542 regulation of SNARE complex assembly;GO:0042144 vacuole fusion, non-autophagic;GO:0006886 intracellular protein transport;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P12868-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12904-1", "uniprot_id": "AAKG_YEAST", "mass": 36401.0, "length": 322, "protein_name": "5'-AMP-activated protein kinase subunit gamma", "gene_name": "SNF4", "organism": "Yeast", "refseq_name": "AMP-activated serine/threonine-protein kinase regulatory subunit SNF4", "refseq_ac": "NP_011400", "gene_names_uniprotkb": "SNF4; CAT3; SCI1", "gene_names_refseq": "CAT3; SCI1; SNF4", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit gamma; AMPK gamma; AMPK subunit gamma; Regulatory protein CAT3; Sucrose non-fermenting protein 4", "protein_names_refseq": "AMP-activated serine/threonine-protein kinase regulatory subunit SNF4", "tax_id": 559292, "disease": "lethal congenital glycogen storage disease of heart (Disease Ontology:DOID:0090101); hypertrophic cardiomyopathy 6 (Disease Ontology:DOID:0110312); neurodegenerative disease (Disease Ontology:DOID:1289); glycogen storage disease (Disease Ontology:DOID:2747); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384)", "pathway": " (sce:YGL115W); (R-SCE-1632852); (R-SCE-163680); (R-SCE-200425); (R-SCE-380972)", "pathway_count": 5, "publication_count": 31, "publication_id_list": "10099331;10224244;11486005;12393914;12960168;14562106;1468623;16847059;17223533;17237508;17851534;18474591;20489023;2169717;22019086;24374639;2481228;2557546;3049255;3049551;3939253;6392017;7050076;7905477;8224185;8544831;8985180;9121458;9169869;9600950;9841784", "class_list": "", "function": "Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU32", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016208 AMP binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007031 peroxisome organization;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P12904-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12945-1", "uniprot_id": "NAT1_YEAST", "mass": 98905.0, "length": 854, "protein_name": "N-terminal acetyltransferase A complex subunit NAT1", "gene_name": "NAT1", "organism": "Yeast", "refseq_name": "peptide alpha-N-acetyltransferase complex A subunit NAT1", "refseq_ac": "NP_010244", "gene_names_uniprotkb": "NAT1; AAA1; D2720", "gene_names_refseq": "AAA1; NAA15; NAT1", "protein_names_uniprotkb": "N-terminal acetyltransferase A complex subunit NAT1; Amino-terminal, alpha-amino, acetyltransferase 1; NatA complex subunit NAT1", "protein_names_refseq": "peptide alpha-N-acetyltransferase complex A subunit NAT1", "tax_id": 559292, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 50 (Disease Ontology:DOID:0080233); intellectual disability (Disease Ontology:DOID:1059); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YDL040C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14517307;14562095;14562106;1600941;18407956;21126336;23749301;24374639;2551674;2663856;33481703;33491328;9169867", "class_list": "", "function": "Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRV5", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031415 NatA complex", "go_biological_process": "GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P12945-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12954-1", "uniprot_id": "SRS2_YEAST", "mass": 134306.0, "length": 1174, "protein_name": "ATP-dependent DNA helicase SRS2", "gene_name": "SRS2", "organism": "Yeast", "refseq_name": "DNA helicase SRS2", "refseq_ac": "NP_012443", "gene_names_uniprotkb": "SRS2; HPR5; J0913; RADH", "gene_names_refseq": "HPR5; SRS2", "protein_names_uniprotkb": "ATP-dependent DNA helicase SRS2; 5.6.2.4; DNA 3'-5' helicase SRS2", "protein_names_refseq": "DNA helicase SRS2", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL092W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;15964827;17287358;18407956;19520826;20195513;20713444;23749301;24374639;2552405;32597660;33481703;33491328;33502312;7985424;8419328;8641269", "class_list": "", "function": "ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. The polarity of the helicase activity was determined to be 3' to 5'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW92", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0042262 DNA protection;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P12954-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12962-1", "uniprot_id": "CAF20_YEAST", "mass": 18223.0, "length": 161, "protein_name": "Cap-associated protein CAF20", "gene_name": "CAF20", "organism": "Yeast", "refseq_name": "Caf20p", "refseq_ac": "NP_014919", "gene_names_uniprotkb": "CAF20; CAF2; CAP20; O5453W", "gene_names_refseq": "CAF20; CAF2; CAP20", "protein_names_uniprotkb": "Cap-associated protein CAF20; 20 kDa cap-associated protein; CCR4-associated factor 2; p20", "protein_names_refseq": "Caf20p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR276W)", "pathway_count": 1, "publication_count": 37, "publication_id_list": "10848587;12054793;12372297;12406227;1400427;14562095;14562106;15665377;17041186;17083129;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;24909858;2678000;30516470;32027465;32597660;33481703;33491328;7592868;8265354;8896271;9118949;9144215;9169874;9707439", "class_list": "", "function": "Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA. Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631. Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2X6", "ec_number_list": "", "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0045727 positive regulation of translation;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0030447 filamentous growth", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P12962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13045-1", "uniprot_id": "GAL3_YEAST", "mass": 58129.0, "length": 520, "protein_name": "Protein GAL3", "gene_name": "GAL3", "organism": "Yeast", "refseq_name": "transcriptional regulator GAL3", "refseq_ac": "NP_010292", "gene_names_uniprotkb": "GAL3; YD8119.14", "gene_names_refseq": "GAL3", "protein_names_uniprotkb": "Protein GAL3", "protein_names_refseq": "transcriptional regulator GAL3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR009W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17322287;22814378;24374639;3062381;33491328;8896275;9169867", "class_list": "", "function": "The GAL3 regulatory function is required for rapid induction of the galactose system. At normal induction, galactose in the presence of the GAL3 protein may lead to the induction of the GAL genes, including GAL1. Then the galactokinase protein (GAL1) in the presence of galactose may reinforce the induction leading to a higher expression level. Upon depletion of galactose, the inducing activity of the galactokinase protein may decrease, after which transcription of the GAL genes, including GAL1, may decrease., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRZ6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0004335 galactokinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose;GO:0045185 maintenance of protein location;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P13045-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13365-1", "uniprot_id": "CG13_YEAST", "mass": 64991.0, "length": 580, "protein_name": "G1/S-specific cyclin CLN3", "gene_name": "CLN3", "organism": "Yeast", "refseq_name": "cyclin CLN3", "refseq_ac": "NP_009360", "gene_names_uniprotkb": "CLN3; DAF1; FUN10; WHI1", "gene_names_refseq": "CLN3; DAF1; FUN10; WHI1", "protein_names_uniprotkb": "G1/S-specific cyclin CLN3", "protein_names_refseq": "cyclin CLN3", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YAL040C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17322287;23749301;24374639;2907481;3062366;33481703;7731988;7823941", "class_list": "", "function": "Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH6;E9P940", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0001932 regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P13365-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13574-1", "uniprot_id": "STE12_YEAST", "mass": 77867.0, "length": 688, "protein_name": "Protein STE12", "gene_name": "STE12", "organism": "Yeast", "refseq_name": "homeodomain family transcription factor STE12", "refseq_ac": "NP_011952", "gene_names_uniprotkb": "STE12", "gene_names_refseq": "STE12", "protein_names_uniprotkb": "Protein STE12", "protein_names_refseq": "homeodomain family transcription factor STE12", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR084W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "12520306;14562106;15665377;17287358;17330950;17563356;18407956;1944269;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;22814378;23749301;24374639;2558054;2668945;30516470;32597660;33481703;33491328;8091229;8339934", "class_list": "", "function": "Binds to the DNA sequence mediating pheromone induction (called the pheromone response element = PRE) which is found in the upstream control region of several a-, alpha- and haploid-specific genes. Involved in mating of haploids and in pseudohyphae formation in diploids., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DL35", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990526 Ste12p-Dig1p-Dig2p complex;GO:1990527 Tec1p-Ste12p-Dig1p complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071444 cellular response to pheromone;GO:0000747 conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P13574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14681-1", "uniprot_id": "KSS1_YEAST", "mass": 42692.0, "length": 368, "protein_name": "Mitogen-activated protein kinase KSS1", "gene_name": "KSS1", "organism": "Yeast", "refseq_name": "mitogen-activated serine/threonine-protein kinase KSS1", "refseq_ac": "NP_011554", "gene_names_uniprotkb": "KSS1", "gene_names_refseq": "KSS1", "protein_names_uniprotkb": "Mitogen-activated protein kinase KSS1; 2.7.11.24; Kinase suppressor of SST2; MAP kinase KSS1", "protein_names_refseq": "mitogen-activated serine/threonine-protein kinase KSS1", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); Noonan syndrome 13 (Disease Ontology:DOID:0112161); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); gastric ulcer (Disease Ontology:DOID:10808); urethral obstruction (Disease Ontology:DOID:12577); velocardiofacial syndrome (Disease Ontology:DOID:12583); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); thyroid cancer (Disease Ontology:DOID:1781); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); morphine dependence (Disease Ontology:DOID:2560); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); coronary restenosis (Disease Ontology:DOID:4247); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); childhood pilocytic astrocytoma (Disease Ontology:DOID:6812); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YGR040W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11583629;11781566;12520306;12732146;14562106;14734536;16273108;1628831;17322287;17330950;20489023;21460040;22875986;24374639;2673544;33481703;33491328;7579701;8918885;9169869;9290212;9393860;9744865;9860980", "class_list": "", "function": "Together with closely related FUS3, KSS1 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated KSS1 activates both pathways, whereas activated FUS3 activates the mating but suppresses the filamentation pathway. KSS1 activity is down-regulated by FUS3 during pheromone induction to prevent inappropriate activation of the filamentation pathway. During induction of filamentation, KSS1 activates the transcription factor STE12 resulting in its binding to and activation of filamentation specific genes. Non-activated KSS1 has a kinase-independent repressive effect on STE12 transcriptional activity, that is mediated by direct binding to STE12 and depends on the presence of DIG1 and DIG2, and that is required for the suppression of filamentation under normal growth conditions. SSN3/SRB10 contributes further to the suppression of filamentation under these conditions by reducing STE12 stability independent of KSS1. FUS3 can partially compensate for the lack of KSS1 but filamentation becomes constitutively induced at a low level in the absence of any signal. KSS1 phosphorylates STE7, STE5, FAR1, DIG1, DIG2, STE12, and SST2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUH8;Q45U43", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042597 periplasmic space;GO:0005935 cellular bud neck", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000749 response to pheromone triggering conjugation with cellular fusion;GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion;GO:0001402 signal transduction involved in filamentous growth;GO:0001403 invasive growth in response to glucose limitation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P14681-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14741-1", "uniprot_id": "EI2BA_YEAST", "mass": 34025.0, "length": 305, "protein_name": "Translation initiation factor eIF2B subunit alpha", "gene_name": "GCN3", "organism": "Yeast", "refseq_name": "translation initiation factor eIF2B subunit alpha", "refseq_ac": "NP_012951", "gene_names_uniprotkb": "GCN3; AAS2; TIF221", "gene_names_refseq": "AAS2; GCN3", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit alpha; GCD complex subunit GCN3; Guanine nucleotide exchange factor subunit GCN3; Translational activator GCN3; eIF2B GDP-GTP exchange factor subunit alpha", "protein_names_refseq": "translation initiation factor eIF2B subunit alpha", "tax_id": 559292, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 1 (Disease Ontology:DOID:0070374)", "pathway": " (sce:YKR026C); (R-SCE-72731)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10733573;14562106;18407956;22814378;24374639;3062370;8196765;8506384;9472020", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:8506384, PubMed:9472020). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the translation of GCN4 in response to low amino acid, carbon, or purine availability, by suppressing the inhibitory effects of multiple uORFs present in the leader of GCN4 mRNA (PubMed:10733573). It may promote either repression or activation of GCN4 expression depending on amino acid availability (PubMed:8506384). Modulation of GCN3 regulatory function in response to amino acid availability occurs post-translationally (PubMed:8506384, PubMed:9472020)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX91", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0045948 positive regulation of translational initiation;GO:1900036 positive regulation of cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P14741-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15108-1", "uniprot_id": "HSC82_YEAST", "mass": 80900.0, "length": 705, "protein_name": "ATP-dependent molecular chaperone HSC82", "gene_name": "HSC82", "organism": "Yeast", "refseq_name": "Hsp90 family chaperone HSC82", "refseq_ac": "NP_013911", "gene_names_uniprotkb": "HSC82; YM8010.16", "gene_names_refseq": "HSC82; HSP90", "protein_names_uniprotkb": "ATP-dependent molecular chaperone HSC82; 82 kDa heat shock cognate protein; Heat shock protein Hsp90 constitutive isoform", "protein_names_refseq": "Hsp90 family chaperone HSC82", "tax_id": 559292, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); varicocele (Disease Ontology:DOID:12337); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); pancreatitis (Disease Ontology:DOID:4989); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (sce:YMR186W); (R-SCE-1474151); (R-SCE-203615); (R-SCE-3371497); (R-SCE-3371511); (R-SCE-3371571); (R-SCE-5218920); (R-SCE-6798695); (R-SCE-8939211); (R-SCE-9009391)", "pathway_count": 10, "publication_count": 26, "publication_id_list": "11094077;12121981;14562095;14562106;14576278;15340069;17287358;17330950;17563356;18086883;18407956;19779198;20159553;20702584;21126336;21576760;23749301;24374639;2674684;30516470;32597660;33481703;33491328;7483834;9169872;9296388", "class_list": "", "function": "Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction such as CNA2. Undergoes a functional cycle that is linked to its ATPase activity (By similarity). Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 37, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W010", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0034605 cellular response to heat;GO:0000723 telomere maintenance;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P15108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15705-1", "uniprot_id": "STI1_YEAST", "mass": 66265.0, "length": 589, "protein_name": "Heat shock protein STI1", "gene_name": "STI1", "organism": "Yeast", "refseq_name": "Hsp90 cochaperone STI1", "refseq_ac": "NP_014670", "gene_names_uniprotkb": "STI1; OR26.17", "gene_names_refseq": "STI1", "protein_names_uniprotkb": "Heat shock protein STI1", "protein_names_refseq": "Hsp90 cochaperone STI1", "tax_id": 559292, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815)", "pathway": " (sce:YOR027W); (R-SCE-3371497); (R-SCE-9696273)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "12716905;14562095;14562106;1694969;17563356;18407956;19756047;21126336;21177495;22106047;22227520;22354036;2297790;23749301;24374639;2674681;27412066;29930177;32597660;33229814;33481703;33491328;39739753;7895733;9169874", "class_list": "", "function": "Co-chaperone that regulates HSP70 and HSP90 chaperones (PubMed:12716905, PubMed:2674681). Functions to scaffold chaperone complexes under basal conditions and controls the ATPase activity of HSP90, but also facilitates the transfer of client proteins from HSP70 to HSP90, thus connecting these two major branches of protein quality control (PubMed:12716905, PubMed:22354036, PubMed:29930177). During high stress, forms cytoplasmic foci and operates independently to sequester soluble misfolded protein in the cytoplasm, a function typically associated with chaperones rather than co-chaperones (PubMed:39739753). Plays a role in mitochondrial function, probably as a cytosolic factors involved in mitochondrial protein import (PubMed:27412066)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W293", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006626 protein targeting to mitochondrion;GO:0006457 protein folding;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P15705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15873-1", "uniprot_id": "PCNA_YEAST", "mass": 28916.0, "length": 258, "protein_name": "DNA sliding clamp PCNA", "gene_name": "POL30", "organism": "Yeast", "refseq_name": "proliferating cell nuclear antigen", "refseq_ac": "NP_009645", "gene_names_uniprotkb": "POL30; YBR0811", "gene_names_refseq": "POL30", "protein_names_uniprotkb": "DNA sliding clamp PCNA; PCNA; Proliferating cell nuclear antigen", "protein_names_refseq": "proliferating cell nuclear antigen", "tax_id": 559292, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); ataxia-telangiectasia-like disorder 2 (Disease Ontology:DOID:0081385); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); leiomyoma (Disease Ontology:DOID:127); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cancer (Disease Ontology:DOID:3571); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YBR088C); (R-SCE-4615885); (R-SCE-5358565); (R-SCE-6782135); (R-SCE-69091); (R-SCE-69166); (R-SCE-69183)", "pathway_count": 7, "publication_count": 21, "publication_id_list": "11545742;12226657;14562106;15166219;15201901;15542864;16782870;17322287;1970160;22814378;22829782;23747975;24374639;33481703;33491328;33502312;37594077;7813418;7900426;8001157;9343398", "class_list": "", "function": "Confers DNA tethering and processivity to DNA polymerases and other proteins (PubMed:9343398, PubMed:11545742, PubMed:12226657, PubMed:23747975). Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand (PubMed:9343398, PubMed:11545742). Additionally, acts as a molecular switch to control the choice of two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypasses replication-blocking lesions without removing them; the translesion DNA synthesis (TLS) branch, and the template-switching (TS) branch; monoubiquitinated PCNA promotes the TLS branch and polyubiquitinated PCNA promotes the TS branch (PubMed:12226657, PubMed:23747975). Within TLS, it can either directly recruit REV1 to stressed replication forks, or indirectly following RAD5 recruitment (PubMed:37594077)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ89", "ec_number_list": "", "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0043626 PCNA complex;GO:0005634 nucleus;GO:0005657 replication fork;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006273 lagging strand elongation;GO:0000710 meiotic mismatch repair;GO:0031509 subtelomeric heterochromatin formation;GO:0000278 mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P15873-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16370-1", "uniprot_id": "RPB3_YEAST", "mass": 35298.0, "length": 318, "protein_name": "DNA-directed RNA polymerase II subunit RPB3", "gene_name": "RPB3", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase II core subunit RPB3", "refseq_ac": "NP_012243", "gene_names_uniprotkb": "RPB3", "gene_names_refseq": "RPB3", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB3; B44.5; DNA-directed RNA polymerase II 45 kDa polypeptide; RNA polymerase II subunit 3; RNA polymerase II subunit B3", "protein_names_refseq": "DNA-directed RNA polymerase II core subunit RPB3", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL021W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 16, "publication_count": 20, "publication_id_list": "11313498;11313499;11805306;12746495;12746498;12914699;14562106;14580350;14963322;15537538;15591044;15610738;16341226;16537912;16765890;22814378;24374639;2685562;33491328;9169870", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Seems to be involved in transcription termination., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVQ8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006369 termination of RNA polymerase II transcription;GO:0001172 RNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P16370-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16892-1", "uniprot_id": "FUS3_YEAST", "mass": 40772.0, "length": 353, "protein_name": "Mitogen-activated protein kinase FUS3", "gene_name": "FUS3", "organism": "Yeast", "refseq_name": "mitogen-activated serine/threonine-protein kinase FUS3", "refseq_ac": "NP_009537", "gene_names_uniprotkb": "FUS3; DAC2; YBL03.21; YBL0303", "gene_names_refseq": "DAC2; FUS3", "protein_names_uniprotkb": "Mitogen-activated protein kinase FUS3; 2.7.11.24; MAP kinase FUS3", "protein_names_refseq": "mitogen-activated serine/threonine-protein kinase FUS3", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); Noonan syndrome 13 (Disease Ontology:DOID:0112161); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); gastric ulcer (Disease Ontology:DOID:10808); urethral obstruction (Disease Ontology:DOID:12577); velocardiofacial syndrome (Disease Ontology:DOID:12583); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); thyroid cancer (Disease Ontology:DOID:1781); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); morphine dependence (Disease Ontology:DOID:2560); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); coronary restenosis (Disease Ontology:DOID:4247); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); childhood pilocytic astrocytoma (Disease Ontology:DOID:6812); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YBL016W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11583629;11781566;12732146;1441754;14562106;1465115;14734536;15665377;1628831;17322287;17330950;18407956;18596411;20489023;22106047;23749301;2406028;24374639;32597660;32661402;33481703;33491328;7813418;8306972;8384702;8455599;9094309;9224718;9393860", "class_list": "", "function": "Together with closely related KSS1, FUS3 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated FUS3 activates the mating but suppresses the filamentation pathway, whereas activated KSS1 activates both pathways. Pheromone-activated FUS3 functions by inhibiting the binding of the transcriptional activator STE12 to filamentation specific genes while inducing its binding to and activity at mating specific genes. Non-activated FUS3 has a repressive effect on STE12 transcriptional activity. KSS1 can partially compensate for the lack of FUS3 but mating efficiency is reduced and the filamentation program is partially activated upon pheromone signaling. FUS3 phosphorylates STE7, STE5, FAR1, DIG1, DIG2 and STE12., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY4", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0010494 cytoplasmic stress granule;GO:0042597 periplasmic space", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051301 cell division;GO:0046827 positive regulation of protein export from nucleus;GO:0043409 negative regulation of MAPK cascade;GO:0010526 transposable element silencing", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P16892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17065-1", "uniprot_id": "SEC2_YEAST", "mass": 84652.0, "length": 759, "protein_name": "Rab guanine nucleotide exchange factor SEC2", "gene_name": "SEC2", "organism": "Yeast", "refseq_name": "guanine nucleotide exchange factor SEC2", "refseq_ac": "NP_014127", "gene_names_uniprotkb": "SEC2; N0641", "gene_names_refseq": "SEC2", "protein_names_uniprotkb": "Rab guanine nucleotide exchange factor SEC2; GDP-GTP exchange factor SEC2", "protein_names_refseq": "guanine nucleotide exchange factor SEC2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL272C); (R-SCE-5620912); (R-SCE-8876198)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10747090;12045183;14562106;1693620;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;32597660;33481703;33491328;9169873;9199166", "class_list": "", "function": "Guanine nucleotide exchange factor for SEC4, catalyzing the dissociation of GDP from SEC4 and also potently promoting binding of GTP. Activation of SEC4 by SEC2 is needed for the directed transport of vesicles to sites of exocytosis. Binds the Rab GTPase YPT32, but does not have exchange activity on YPT32., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0S2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005829 cytosol;GO:0030133 transport vesicle;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:0006887 exocytosis;GO:0030435 sporulation resulting in formation of a cellular spore;GO:0032120 ascospore-type prospore membrane formation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P17065-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17157-1", "uniprot_id": "PHO85_YEAST", "mass": 34906.0, "length": 305, "protein_name": "Cyclin-dependent protein kinase PHO85", "gene_name": "PHO85", "organism": "Yeast", "refseq_name": "cyclin-dependent serine/threonine-protein kinase PHO85", "refseq_ac": "NP_015294", "gene_names_uniprotkb": "PHO85; P7102.18A; SSG3", "gene_names_refseq": "LDB15; PHO85", "protein_names_uniprotkb": "Cyclin-dependent protein kinase PHO85; 2.7.11.22; Negative regulator of the PHO system; Serine/threonine-protein kinase PHO85", "protein_names_refseq": "cyclin-dependent serine/threonine-protein kinase PHO85", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 7 with cerebellar hypoplasia (Disease Ontology:DOID:0112231); Alzheimer's disease (Disease Ontology:DOID:10652); trigeminal neuralgia (Disease Ontology:DOID:12098); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (sce:YPL031C)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "10490639;10620010;10692159;11069666;11602261;11675494;12006994;12098764;12101234;12407105;12455686;12857883;14562106;15057567;15082539;15598647;15721288;16308562;16455487;22106047;24374639;3067079;3320965;33491328;7939631;7973730;7973731;8108735;8539622;9032248;9169875;9584169;9593297;9725902;9843683", "class_list": "", "function": "Cyclin-dependent protein kinase (CDK) catalytic subunit that regulates multiple cell cycle and metabolic processes in response to nutrient availability. Associates with different cyclins, that control kinase activity, substrate specificity and subcellular location of the kinase. Regulates metabolic processes when associated with PHO80 cyclin family members (PH080, PCL6, PCL7, PCL8 and PCL10), and cell cycle and morphogenesis processes when associated with PCL1,2 cyclin family members (PCL1, PCL2, CLG1, PCL5 and PCL9) (PubMed:10490639, PubMed:10692159, PubMed:11602261, PubMed:12006994, PubMed:12098764, PubMed:12101234, PubMed:12407105, PubMed:12455686, PubMed:12857883, PubMed:15057567, PubMed:15082539, PubMed:15598647, PubMed:15721288, PubMed:16308562, PubMed:16455487, PubMed:3067079, PubMed:7973730, PubMed:8108735, PubMed:8539622, PubMed:9584169, PubMed:9593297, PubMed:9725902, PubMed:9843683). When associated with PHO80, negatively regulates the expression of phosphate-starvation-responsive genes under phosphate-rich conditions (PubMed:3067079, PubMed:8108735). The PHO80-PHO85 cyclin-CDK holoenzyme phosphorylates and inactivates the transcription factor PHO4 by promoting its export to the cytoplasm (PubMed:8108735). PHO80-PHO85 phosphorylates and inactivates protein kinase RIM15 by retaining it in the cytoplasm, antagonizing RIM15-induced entry into stationary phase (PubMed:16308562). PHO80-PHO85 also phosphorylates and inactivates the calcineurin-responsive transcription factor CRZ1, linking cyclin-CDK activity to calcium signaling (PubMed:16455487). PHO80-PHO85 phosphorylates MMR1 (PubMed:12006994). Together with the cyclins PCL6/PCL7 and PCL8/PCL10, negatively controls glycogen accumulation (PubMed:10490639, PubMed:11602261, PubMed:12407105, PubMed:15721288, PubMed:8539622, PubMed:9584169). When associated with cyclins PCL6 and PCL7, controls glycogen phosphorylase and glycogen synthase activities (PubMed:11602261, PubMed:12407105, PubMed:15721288). PCL6-PHO85 and PCL7-PHO85 phosphorylate and inactivate the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase (PubMed:12407105). PCL7-PHO85 phosphorylate ALY2 (PubMed:12098764). PCL10-PHO85 phosphorylates and negatively regulates glycogen synthase GSY2 (PubMed:9584169). Association with PCL1 and PCL2 is required for cell cycle progression at start in the absence of the CDC28-dependent G1 cyclins CLN1 and CLN2 (PubMed:7973730, PubMed:7973731). PCL1-PHO85 is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis (PubMed:9725902). When associated with cyclins PCL1 and PCL2, positively controls degradation of sphingoid long chain base kinase LCB4 via phosphorylation of LCB4, which is required for its ubiquitination and degradation (PubMed:15598647). PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit (PubMed:15082539). PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton (PubMed:12857883, PubMed:9843683). When associated with PCL5, positively controls degradation of transcription factor GCN4 via phosphorylation of GCN4, which is required for its degradation by the E3 ubiquitin ligase complex SCF(Cdc4) (PubMed:12101234, PubMed:12455686). When associated with PCL9, may have a role in bud site selection in G1 phase (PubMed:9593297). PHO85 also phosphorylates the transcription factor SWI5 (PubMed:10692159)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Y2;Q03089;Q06888", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:1990860 Pho85-Pho80 CDK-cyclin complex;GO:0005935 cellular bud neck", "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001676 long-chain fatty acid metabolic process;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P17157-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17505-1", "uniprot_id": "MDHM_YEAST", "mass": 35650.0, "length": 334, "protein_name": "Malate dehydrogenase, mitochondrial", "gene_name": "MDH1", "organism": "Yeast", "refseq_name": "malate dehydrogenase MDH1", "refseq_ac": "NP_012838", "gene_names_uniprotkb": "MDH1", "gene_names_refseq": "MDH1", "protein_names_uniprotkb": "Malate dehydrogenase, mitochondrial; 1.1.1.37", "protein_names_refseq": "malate dehydrogenase MDH1", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 51 (Disease Ontology:DOID:0080433); brain ischemia (Disease Ontology:DOID:2316); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (sce:YKL085W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11502169;14562106;17322287;17761666;19779198;23749301;24374639;3072021;33491328;3552052;8196765", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK3;E9P8U0", "ec_number_list": "1.1.1.37", "go_molecular_function": "GO:0003729 mRNA binding;GO:0030060 L-malate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0009060 aerobic respiration;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P17505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17555-1", "uniprot_id": "CAP_YEAST", "mass": 57521.0, "length": 526, "protein_name": "Adenylyl cyclase-associated protein", "gene_name": "SRV2", "organism": "Yeast", "refseq_name": "adenylate cyclase-binding protein", "refseq_ac": "NP_014261", "gene_names_uniprotkb": "SRV2; CAP1; N1210; N1838", "gene_names_refseq": "CAP; SRV2", "protein_names_uniprotkb": "Adenylyl cyclase-associated protein; CAP", "protein_names_refseq": "adenylate cyclase-binding protein", "tax_id": 559292, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152)", "pathway": " (sce:YNL138W); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;15311924;18407956;19779198;21126336;2158860;2184942;22814378;23749301;24374639;30377154;32597660;33481703;33491328;8552082;8619318;9169873", "class_list": "", "function": "The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W144", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0008179 adenylate cyclase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030479 actin cortical patch;GO:0043332 mating projection tip", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0007015 actin filament organization;GO:0007265 Ras protein signal transduction;GO:0051014 actin filament severing;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P17555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18239-1", "uniprot_id": "ADT2_YEAST", "mass": 34426.0, "length": 318, "protein_name": "ADP/ATP translocase 2", "gene_name": "PET9", "organism": "Yeast", "refseq_name": "ADP/ATP carrier protein PET9", "refseq_ac": "NP_009523", "gene_names_uniprotkb": "PET9; AAC2; YBL0421", "gene_names_refseq": "AAC2; ANC2; PET9", "protein_names_uniprotkb": "ADP/ATP translocase 2; ADP,ATP carrier protein 2; ANT 2; Adenine nucleotide translocator 2; Petite colonies protein 9", "protein_names_refseq": "ADP/ATP carrier protein PET9", "tax_id": 559292, "disease": "mitochondrial DNA depletion syndrome 12a (Disease Ontology:DOID:0080130); Sengers syndrome (Disease Ontology:DOID:0080132); mitochondrial DNA depletion syndrome 12b (Disease Ontology:DOID:0080335); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111517); Alzheimer's disease (Disease Ontology:DOID:10652); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); epilepsy (Disease Ontology:DOID:1826); lactic acidosis (Disease Ontology:DOID:3650); mitochondrial myopathy (Disease Ontology:DOID:699); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YBL030C); (R-SCE-1268020); (R-SCE-166187); (R-SCE-83936); (R-SCE-9837999)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "17056710;17566106;17572439;17761666;19779198;2165073;2167309;24374639;24474793;2844786;32597660;33255957;33481703;33491328;35127709;7683726;7725803;7813418;795470;8487299", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:17056710, PubMed:17572439, PubMed:17566106, PubMed:24474793, PubMed:33255957). Also mediates import of ATP into the peroxisome (PubMed:35127709). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW9", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005471 ATP:ADP antiporter activity;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005778 peroxisomal membrane;GO:0016020 membrane;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0055085 transmembrane transport;GO:0006915 apoptotic process;GO:0046902 regulation of mitochondrial membrane permeability;GO:0015886 heme transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P18239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18851-1", "uniprot_id": "GBB_YEAST", "mass": 46581.0, "length": 423, "protein_name": "Guanine nucleotide-binding protein subunit beta", "gene_name": "STE4", "organism": "Yeast", "refseq_name": "G protein subunit beta", "refseq_ac": "NP_014855", "gene_names_uniprotkb": "STE4; YOR50-2", "gene_names_refseq": "HMD2; STE4", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta", "protein_names_refseq": "G protein subunit beta", "tax_id": 559292, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal dominant intellectual developmental disorder 42 (Disease Ontology:DOID:0070072); Lodder-Merla syndrome type 1 with impaired intellectual development and cardiac arrhythmia (Disease Ontology:DOID:0081008); Charcot-Marie-Tooth disease dominant intermediate F (Disease Ontology:DOID:0110206); congenital stationary night blindness 1H (Disease Ontology:DOID:0110866); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); familial hyperlipidemia (Disease Ontology:DOID:1168); depressive disorder (Disease Ontology:DOID:1596); carotid artery disease (Disease Ontology:DOID:3407); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YOR212W); (R-SCE-6814122)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10749875;14562106;18407956;19779198;23749301;24374639;2536595;32597660;33481703;33491328;7592711;8840505;9169874;9671029", "class_list": "", "function": "Implicated in the a- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R8", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding;GO:0031267 small GTPase binding;GO:0097110 scaffold protein binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0031680 G-protein beta/gamma-subunit complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0061951 establishment of protein localization to plasma membrane;GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion;GO:0043577 chemotropism;GO:1903260 protein localization to mating projection tip", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P18851-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18900-1", "uniprot_id": "COQ1_YEAST", "mass": 52560.0, "length": 473, "protein_name": "Hexaprenyl pyrophosphate synthase, mitochondrial", "gene_name": "COQ1", "organism": "Yeast", "refseq_name": "trans-hexaprenyltranstransferase", "refseq_ac": "NP_009557", "gene_names_uniprotkb": "COQ1; YBR0109", "gene_names_refseq": "COQ1", "protein_names_uniprotkb": "Hexaprenyl pyrophosphate synthase, mitochondrial; 2.5.1.-; HPS", "protein_names_refseq": "trans-hexaprenyltranstransferase", "tax_id": 559292, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 2 (Disease Ontology:DOID:0070239)", "pathway": " (sce:YBR003W); (R-SCE-2142789)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14562106;17322287;2198286;24374639;7813418;8091860", "class_list": "", "function": "Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ04", "ec_number_list": "2.5.1.-", "go_molecular_function": "GO:0000010 heptaprenyl diphosphate synthase activity;GO:0046872 metal ion binding;GO:0004659 prenyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0032476 polyprenyl diphosphate synthase complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19073-1", "uniprot_id": "CDC42_YEAST", "mass": 21323.0, "length": 191, "protein_name": "Cell division control protein 42", "gene_name": "CDC42", "organism": "Yeast", "refseq_name": "Rho family GTPase CDC42", "refseq_ac": "NP_013330", "gene_names_uniprotkb": "CDC42; L8083.13; SRO2", "gene_names_refseq": "CDC42", "protein_names_uniprotkb": "Cell division control protein 42; 3.6.5.2; Suppressor of RHO3 protein 2", "protein_names_refseq": "Rho family GTPase CDC42", "tax_id": 559292, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); microvillus inclusion disease (Disease Ontology:DOID:0060775); Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic cancer (Disease Ontology:DOID:1793); syndrome (Disease Ontology:DOID:225); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); fibrosarcoma (Disease Ontology:DOID:3355); rhinitis (Disease Ontology:DOID:4483); myelofibrosis (Disease Ontology:DOID:4971); kidney disease (Disease Ontology:DOID:557); cleft palate (Disease Ontology:DOID:674)", "pathway": " (sce:YLR229C); (R-SCE-2029482); (R-SCE-389359); (R-SCE-5626467); (R-SCE-5627123); (R-SCE-5687128); (R-SCE-9013148); (R-SCE-9013406); (R-SCE-9013409); (R-SCE-9013420); (R-SCE-9013424); (R-SCE-983231)", "pathway_count": 12, "publication_count": 9, "publication_id_list": "17322287;17460121;2164028;24374639;33491328;7498791;8754839;9169871;9178507", "class_list": "", "function": "Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYN1;Q05978", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5;2.3.2.26;3.4.-.-;2.7.11.1;3.6.4.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005940 septin ring;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007266 Rho protein signal transduction;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P19073-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19097-1", "uniprot_id": "FAS2_YEAST", "mass": 206947.0, "length": 1887, "protein_name": "Fatty acid synthase subunit alpha", "gene_name": "FAS2", "organism": "Yeast", "refseq_name": "trifunctional fatty acid synthase subunit FAS2", "refseq_ac": "NP_015093", "gene_names_uniprotkb": "FAS2; P1409", "gene_names_refseq": "FAS2", "protein_names_uniprotkb": "Fatty acid synthase subunit alpha; 2.3.1.86; Beta-ketoacyl reductase; Beta-ketoacyl synthase", "protein_names_refseq": "trifunctional fatty acid synthase subunit FAS2", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL231W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;15665377;17330950;17431182;17448991;17761666;18407956;18725634;19679086;19779198;19795423;19823750;21126336;21177495;22106047;23749301;24374639;2900835;32597660;33481703;33491328;8041367;9169875", "class_list": "", "function": "Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 79, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3D9;Q12533", "ec_number_list": "1.1.1.100;2.3.1.41;2.3.1.86", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008897 holo-[acyl-carrier-protein] synthase activity;GO:0004321 fatty-acyl-CoA synthase activity;GO:0004312 fatty acid synthase activity;GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005835 fatty acid synthase complex", "go_biological_process": "GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P19097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19146-1", "uniprot_id": "ARF2_YEAST", "mass": 20658.0, "length": 181, "protein_name": "ADP-ribosylation factor 2", "gene_name": "ARF2", "organism": "Yeast", "refseq_name": "Arf family GTPase ARF2", "refseq_ac": "NP_010144", "gene_names_uniprotkb": "ARF2; D2165", "gene_names_refseq": "ARF2", "protein_names_uniprotkb": "ADP-ribosylation factor 2", "protein_names_refseq": "Arf family GTPase ARF2", "tax_id": 559292, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (sce:YDL137W); (R-SCE-1660499); (R-SCE-1660514); (R-SCE-199992); (R-SCE-5620916); (R-SCE-6807878); (R-SCE-6811434); (R-SCE-6811438)", "pathway_count": 8, "publication_count": 14, "publication_id_list": "11535602;14562095;14562106;17244705;17322287;17563356;18407956;20702584;21126336;2123295;23749301;24374639;8972577;9169867", "class_list": "", "function": "GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBP3;D6VRL1", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P19146-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19262-1", "uniprot_id": "ODO2_YEAST", "mass": 50431.0, "length": 463, "protein_name": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial", "gene_name": "KGD2", "organism": "Yeast", "refseq_name": "dihydrolipoyl transsuccinylase", "refseq_ac": "NP_010432", "gene_names_uniprotkb": "KGD2; YD8358.05C", "gene_names_refseq": "KGD2", "protein_names_uniprotkb": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; 2.3.1.61; Alpha-ketoglutarate dehydrogenase subunit E2; DLST; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; OGDC-E2; OGDHC subunit E2; alpha-KGDHC subunit E2", "protein_names_refseq": "dihydrolipoyl transsuccinylase", "tax_id": 559292, "disease": "pheochromocytoma/paraganglioma syndrome 7 (Disease Ontology:DOID:0061222); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (sce:YDR148C); (R-SCE-6783984); (R-SCE-9853506); (R-SCE-9857492)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "14562106;17761666;2072900;2115121;24374639;25165143;32597660;33491328;9169867", "class_list": "", "function": "The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSD1", "ec_number_list": "1.8.1.4;2.3.1.61;1.2.4.2;6.3.1.20", "go_molecular_function": "GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P19262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19358-1", "uniprot_id": "METK2_YEAST", "mass": 42256.0, "length": 384, "protein_name": "S-adenosylmethionine synthase 2", "gene_name": "SAM2", "organism": "Yeast", "refseq_name": "methionine adenosyltransferase SAM2", "refseq_ac": "NP_010790", "gene_names_uniprotkb": "SAM2; D9719.8; ETH2", "gene_names_refseq": "ETH2; SAM2", "protein_names_uniprotkb": "S-adenosylmethionine synthase 2; 2.5.1.6; AdoMet synthase 2; MAT 2; Methionine adenosyltransferase 2", "protein_names_refseq": "methionine adenosyltransferase SAM2", "tax_id": 559292, "disease": "hypermethioninemia (Disease Ontology:DOID:0050544); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); lung cancer (Disease Ontology:DOID:1324); lipid metabolism disorder (Disease Ontology:DOID:3146); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YDR502C); (R-SCE-156581); (R-SCE-1614635); (R-SCE-2408508)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "14562106;17287358;17322287;19779198;24374639;3072475;33481703;33491328;9169867;9298649", "class_list": "", "function": "Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTC4;E9P927", "ec_number_list": "2.5.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004478 methionine adenosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006730 one-carbon metabolic process;GO:0040029 epigenetic regulation of gene expression;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0006555 methionine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P19358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19659-1", "uniprot_id": "MED15_YEAST", "mass": 120309.0, "length": 1081, "protein_name": "Mediator of RNA polymerase II transcription subunit 15", "gene_name": "GAL11", "organism": "Yeast", "refseq_name": "Gal11p", "refseq_ac": "NP_014591", "gene_names_uniprotkb": "GAL11; ABE1; MED15; RAR3; SDS4; SPT13", "gene_names_refseq": "ABE1; GAL11; MED15; RAR3; SDS4; SPT13", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 15; Autonomous replication regulatory protein 3; Basal expression activator protein 1; Defective silencing suppressor protein 4; Mediator complex subunit 15; Transcription regulatory protein GAL11; Ty insertion suppressor protein 13", "protein_names_refseq": "Gal11p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL051W)", "pathway_count": 1, "publication_count": 43, "publication_id_list": "11478912;12191485;14562095;14562106;15175151;15477388;15665377;16076843;16109375;16263706;16429153;16630888;17192271;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;19940160;2005915;20489023;20702584;21126336;21177495;22218487;22814378;23749301;24374639;28270554;30516470;3062377;31208443;32597660;33229814;33481703;33491328;33502312;8187178;8789261;9169874", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins. It has an important role in the negative regulation of Ty transcription., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 43, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6W217;Q08221", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0001097 TFIIH-class transcription factor complex binding;GO:0001095 TFIIE-class transcription factor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0070202 regulation of establishment of protein localization to chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P19659-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19812-1", "uniprot_id": "UBR1_YEAST", "mass": 224838.0, "length": 1950, "protein_name": "E3 ubiquitin-protein ligase UBR1", "gene_name": "UBR1", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase UBR1", "refseq_ac": "NP_011700", "gene_names_uniprotkb": "UBR1; G7168; PTR1", "gene_names_refseq": "PTR1; UBR1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR1; 2.3.2.27; N-end-recognizing protein; N-recognin-1", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR1", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); cardiovascular system disease (Disease Ontology:DOID:1287); neurodegenerative disease (Disease Ontology:DOID:1289); Johanson-Blizzard syndrome (Disease Ontology:DOID:14694); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (sce:YGR184C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10581257;10688918;15665377;17330950;18407956;18566452;19033468;19041308;19684113;19779198;19795423;19823750;20702584;21126336;2209542;22814378;23749301;24374639;32597660;33481703;33491328;34789879;9133739;9169869", "class_list": "", "function": "Ubiquitin ligase protein which is a component of the N-end rule pathway (PubMed:10581257, PubMed:18566452, PubMed:19041308, PubMed:2209542, PubMed:34789879). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:10581257, PubMed:18566452, PubMed:19041308, PubMed:2209542, PubMed:34789879). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:18566452, PubMed:34789879)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 26, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW7", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:1904855 proteasome regulatory particle binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex;GO:1990303 UBR1-RAD6 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0036503 ERAD pathway;GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process;GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P19812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19882-1", "uniprot_id": "HSP60_YEAST", "mass": 60752.0, "length": 572, "protein_name": "Heat shock protein 60, mitochondrial", "gene_name": "HSP60", "organism": "Yeast", "refseq_name": "chaperone ATPase HSP60", "refseq_ac": "NP_013360", "gene_names_uniprotkb": "HSP60; L8479.10; MIF4", "gene_names_refseq": "CPN60; HSP60; MIF4; MNA2", "protein_names_uniprotkb": "Heat shock protein 60, mitochondrial; CPN60; P66; Stimulator factor I 66 kDa component", "protein_names_refseq": "chaperone ATPase HSP60", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy 4 (Disease Ontology:DOID:0060789); hereditary spastic paraplegia 13 (Disease Ontology:DOID:0110766); glucose intolerance (Disease Ontology:DOID:10603); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); varicocele (Disease Ontology:DOID:12337); autistic disorder (Disease Ontology:DOID:12849); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); arteriosclerosis (Disease Ontology:DOID:2349); hereditary spastic paraplegia (Disease Ontology:DOID:2476); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); aphthous stomatitis (Disease Ontology:DOID:9663)", "pathway": " (sce:YLR259C); (R-SCE-1268020); (R-SCE-9837999)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11502169;1408806;14690591;17761666;18407956;19779198;21126336;23749301;24374639;2563898;2575559;32597660;33481703;33491328;9169871", "class_list": "", "function": "May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYQ6", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0007005 mitochondrion organization;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P19882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19955-1", "uniprot_id": "KGD4_YEAST", "mass": 13689.0, "length": 123, "protein_name": "Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial", "gene_name": "YMR31", "organism": "Yeast", "refseq_name": "alpha-ketoglutarate dehydrogenase subunit KGD4", "refseq_ac": "NP_116707", "gene_names_uniprotkb": "YMR31; KGD4", "gene_names_refseq": "KGD4; YMR31", "protein_names_uniprotkb": "Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial; 2-oxoglutarate dehydrogenase complex component 4; OGDHC subunit 4; alpha-KGDH subunit 4", "protein_names_refseq": "alpha-ketoglutarate dehydrogenase subunit KGD4", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR049W); (R-SCE-6783984); (R-SCE-9853506)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "14562095;14562106;14576278;17322287;24374639;25165143;2693936;30822412;7670463;8686379", "class_list": "", "function": "Molecular adapter that is necessary to a form a stable 2-oxoglutarate dehydrogenase enzyme complex (OGDC). Required for incorporation of the E3 subunit (LPD1) into the E1-E2 core (KGD1-KGD2) of mitochondrial OGDC, and acting as a stability factor for the fully assembled complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTT2", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005761 mitochondrial ribosome;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P19955-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20434-1", "uniprot_id": "RPAB1_YEAST", "mass": 25079.0, "length": 215, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "gene_name": "RPB5", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase core subunit RPB5", "refseq_ac": "NP_009712", "gene_names_uniprotkb": "RPB5; RPA7; RPC9; YBR1204", "gene_names_refseq": "RPB5", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC1; ABC27; DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide; RNA polymerases I, II, and III subunit ABC1", "protein_names_refseq": "DNA-directed RNA polymerase core subunit RPB5", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR154C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73762); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-76061); (R-SCE-76066); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 20, "publication_count": 27, "publication_id_list": "10384303;10841537;11313498;11313499;11717393;11805306;11918799;12407181;12746495;12746498;12914699;14580350;14963322;15537538;15591044;15610738;16341226;16765890;16818233;18160037;2186966;24153182;24153184;24374639;33491328;7813418;8488729", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. RNA polymerase complexes are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQE9;Q02121", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0042254 ribosome biogenesis;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P20434-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20436-1", "uniprot_id": "RPAB3_YEAST", "mass": 16511.0, "length": 146, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "gene_name": "RPB8", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase core subunit RPB8", "refseq_ac": "NP_014867", "gene_names_uniprotkb": "RPB8; YOR50-14", "gene_names_refseq": "RPB8", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC3; ABC14.4; ABC14.5; DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide; RNA polymerases I, II, and III subunit ABC3", "protein_names_refseq": "DNA-directed RNA polymerase core subunit RPB8", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR224C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73762); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-76061); (R-SCE-76066); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 20, "publication_count": 31, "publication_id_list": "10384303;11313498;11313499;11805306;12407181;12746495;12746498;12914699;14562095;14562106;14580350;14963322;15537538;15591044;15610738;16341226;16765890;16818233;17322287;18160037;18407956;2186966;22814378;24153182;24153184;24374639;30181345;33491328;8840505;9169874;9461075", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription. of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2S9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0042254 ribosome biogenesis;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P20436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20437-1", "uniprot_id": "CG11_YEAST", "mass": 62050.0, "length": 546, "protein_name": "G1/S-specific cyclin CLN1", "gene_name": "CLN1", "organism": "Yeast", "refseq_name": "cyclin CLN1", "refseq_ac": "NP_013926", "gene_names_uniprotkb": "CLN1; YM9646.13", "gene_names_refseq": "CLN1", "protein_names_uniprotkb": "G1/S-specific cyclin CLN1", "protein_names_refseq": "cyclin CLN1", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YMR199W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;17322287;19779198;19795423;19823750;20489023;2197605;23749301;24374639;2569741;32597660;33481703;33491328;9169872", "class_list": "", "function": "Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W024", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0001932 regulation of protein phosphorylation;GO:1902806 regulation of cell cycle G1/S phase transition;GO:0007089 traversing start control point of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P20437-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20438-1", "uniprot_id": "CG12_YEAST", "mass": 61697.0, "length": 545, "protein_name": "G1/S-specific cyclin CLN2", "gene_name": "CLN2", "organism": "Yeast", "refseq_name": "cyclin CLN2", "refseq_ac": "NP_015067", "gene_names_uniprotkb": "CLN2", "gene_names_refseq": "CLN2", "protein_names_uniprotkb": "G1/S-specific cyclin CLN2", "protein_names_refseq": "cyclin CLN2", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YPL256C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;17322287;19795423;19823750;20489023;21177495;2197605;23749301;24374639;2569741;33481703;33491328;8599119;8756727;9169875", "class_list": "", "function": "Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3B5;E9P938", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0001932 regulation of protein phosphorylation;GO:1902806 regulation of cell cycle G1/S phase transition;GO:0007089 traversing start control point of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P20438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20486-1", "uniprot_id": "CKS1_YEAST", "mass": 17795.0, "length": 150, "protein_name": "Cyclin-dependent kinases regulatory subunit", "gene_name": "CKS1", "organism": "Yeast", "refseq_name": "cyclin-dependent protein kinase regulatory subunit CKS1", "refseq_ac": "NP_009693", "gene_names_uniprotkb": "CKS1; YBR1011", "gene_names_refseq": "CKS1", "protein_names_uniprotkb": "Cyclin-dependent kinases regulatory subunit; Cell division control protein CKS1", "protein_names_refseq": "cyclin-dependent protein kinase regulatory subunit CKS1", "tax_id": 559292, "disease": "lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); liver cancer (Disease Ontology:DOID:3571)", "pathway": " (sce:YBR135W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10997903;14562106;17322287;24374639;2664468;7813418;8065923;8091856;8491379", "class_list": "", "function": "Binds to the catalytic subunit of the cyclin dependent kinase (CDC28) and is essential for its biological function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQD1", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0042393 histone binding;GO:0043130 ubiquitin binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:1902806 regulation of cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20486-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20795-1", "uniprot_id": "VPS33_YEAST", "mass": 79271.0, "length": 691, "protein_name": "Vacuolar protein sorting-associated protein 33", "gene_name": "VPS33", "organism": "Yeast", "refseq_name": "tethering complex ATP-binding subunit VPS33", "refseq_ac": "NP_013500", "gene_names_uniprotkb": "VPS33; L8084.15; SLP1; VAM5", "gene_names_refseq": "CLS14; MET27; PEP14; SLP1; VAM5; VPL25; VPS33; VPT33", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 33; Protein SLP1; Vacuolar morphogenesis protein 5", "protein_names_refseq": "tethering complex ATP-binding subunit VPS33", "tax_id": 559292, "disease": "ARC syndrome (Disease Ontology:DOID:0050763); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); arthrogryposis, renal dysfunction, and cholestasis 1 (Disease Ontology:DOID:0111353); cholestasis (Disease Ontology:DOID:13580); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); kidney disease (Disease Ontology:DOID:557)", "pathway": " (sce:YLR396C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12553664;14562106;16601699;18407956;21126336;2183024;2201898;24374639;33481703;33491328;9169871", "class_list": "", "function": "Essential for vacuolar biogenesis, maturation and function. Involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole. Acts as a component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ31", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0033263 CORVET complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0035542 regulation of SNARE complex assembly;GO:0042144 vacuole fusion, non-autophagic;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P20795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21268-1", "uniprot_id": "FAR1_YEAST", "mass": 94572.0, "length": 830, "protein_name": "Cyclin-dependent kinase inhibitor FAR1", "gene_name": "FAR1", "organism": "Yeast", "refseq_name": "cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1", "refseq_ac": "NP_012378", "gene_names_uniprotkb": "FAR1; J0565", "gene_names_refseq": "FAR1", "protein_names_uniprotkb": "Cyclin-dependent kinase inhibitor FAR1; CKI FAR1; Factor arrest protein", "protein_names_refseq": "cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL157C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562106;15335864;15665377;17330950;19520826;19684113;19779198;19795423;19823750;20489023;21126336;2147873;22218487;24374639;31315942;32597660;33481703;33491328;7490290;7739534;8066461;8641269;9251033;9367986;9632750", "class_list": "", "function": "Inhibitor of the cyclin-dependent kinase CDC28. Necessary for cell cycle arrest. Involved in pheromone response. Contributes to mating efficiency. Required for oriented polarization of yeast cells in response to mating pheromones., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 52, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW30", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0120171 Cdc24p-Far1p-Gbetagamma complex;GO:0043332 mating projection tip", "go_biological_process": "GO:0051301 cell division;GO:0051457 maintenance of protein location in nucleus;GO:0000751 mitotic cell cycle G1 arrest in response to pheromone;GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion;GO:0043577 chemotropism", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P21268-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21269-1", "uniprot_id": "CCA1_YEAST", "mass": 62485.0, "length": 546, "protein_name": "CCA tRNA nucleotidyltransferase, mitochondrial", "gene_name": "CCA1", "organism": "Yeast", "refseq_name": "tRNA adenylyltransferase", "refseq_ac": "NP_011095", "gene_names_uniprotkb": "CCA1; TNT1", "gene_names_refseq": "CCA1; TNT1", "protein_names_uniprotkb": "CCA tRNA nucleotidyltransferase, mitochondrial; 2.7.7.72; CCA-adding enzyme; tRNA CCA-pyrophosphorylase; tRNA adenylyltransferase; tRNA nucleotidyltransferase", "protein_names_refseq": "tRNA adenylyltransferase", "tax_id": 559292, "disease": "sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay (Disease Ontology:DOID:0080209); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (sce:YER168C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;1634528;18407956;19795423;19823750;21126336;2204621;23872483;24374639;33491328;8175766;9169868", "class_list": "", "function": "Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates (PubMed:1634528, PubMed:23872483). tRNA 3'-terminal CCA addition is required both for tRNA processing and repair (By similarity). Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs (By similarity). While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded (By similarity). The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA (By similarity). This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DM76", "ec_number_list": "2.7.7.72", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0052927 CC tRNA cytidylyltransferase activity;GO:0052929 ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity;GO:0004810 CCA tRNA nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001680 tRNA 3'-terminal CCA addition", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P21269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21524-1", "uniprot_id": "RIR1_YEAST", "mass": 99561.0, "length": 888, "protein_name": "Ribonucleoside-diphosphate reductase large chain 1", "gene_name": "RNR1", "organism": "Yeast", "refseq_name": "ribonucleotide-diphosphate reductase subunit RNR1", "refseq_ac": "NP_010993", "gene_names_uniprotkb": "RNR1; CRT7; RIR1; SDS12", "gene_names_refseq": "CRT7; RIR1; RNR1; SDS12", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase large chain 1; 1.17.4.1; Ribonucleotide reductase R1 subunit 1; Ribonucleotide reductase large subunit 1", "protein_names_refseq": "ribonucleotide-diphosphate reductase subunit RNR1", "tax_id": 559292, "disease": "chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YER070W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10593972;10716984;11893751;12732713;14562106;15665377;16537479;16537480;17563356;18407956;18610997;19684113;19779198;19795423;19823750;20702584;21177495;2199320;22106047;22218487;23749301;24374639;32597660;33481703;33491328;8121398;9169868", "class_list": "", "function": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLX5", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005971 ribonucleoside-diphosphate reductase complex", "go_biological_process": "GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P21524-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22082-1", "uniprot_id": "SNF2_YEAST", "mass": 194051.0, "length": 1703, "protein_name": "SWI/SNF chromatin-remodeling complex subunit SNF2", "gene_name": "SNF2", "organism": "Yeast", "refseq_name": "SWI/SNF catalytic subunit SNF2", "refseq_ac": "NP_014933", "gene_names_uniprotkb": "SNF2; GAM1; RIC1; SWI2; TYE3", "gene_names_refseq": "GAM1; HAF1; SNF2; SWI2; TYE3", "protein_names_uniprotkb": "SWI/SNF chromatin-remodeling complex subunit SNF2; 3.6.4.-; ATP-dependent chromatin remodeler SNF2; Regulatory protein GAM1; Regulatory protein SWI2; SWI/SNF complex component SNF2; Transcription factor TYE3; Transcription regulatory protein SNF2", "protein_names_refseq": "SWI/SNF catalytic subunit SNF2", "tax_id": 559292, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); rhabdoid tumor predisposition syndrome 2 (Disease Ontology:DOID:0060997); Coffin-Siris syndrome 4 (Disease Ontology:DOID:0070046); Nicolaides-Baraitser syndrome (Disease Ontology:DOID:0081441); prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YOR290C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "12524530;14562106;17330950;17563356;18407956;1886612;1901413;19779198;19795423;19823750;20702584;21126336;21177495;22031224;22106047;22218487;23749301;24374639;32597660;33229814;33481703;33491328;7608126;8871545;8896271;9153758;9169874", "class_list": "", "function": "Catalytic component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Y8", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006302 double-strand break repair;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P22082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22138-1", "uniprot_id": "RPA2_YEAST", "mass": 135742.0, "length": 1203, "protein_name": "DNA-directed RNA polymerase I subunit RPA135", "gene_name": "RPA135", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase I core subunit RPA135", "refseq_ac": "NP_015335", "gene_names_uniprotkb": "RPA135; RPA2; RRN2; SRP3; YP9531.03C", "gene_names_refseq": "RPA135; RPA2; RRN2; SRP3", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA135; 2.7.7.6; A135; DNA-directed RNA polymerase I 135 kDa polypeptide; DNA-directed RNA polymerase I polypeptide 2; RNA polymerase I subunit 2", "protein_names_refseq": "DNA-directed RNA polymerase I core subunit RPA135", "tax_id": 559292, "disease": "Treacher Collins syndrome 4 (Disease Ontology:DOID:0080792); Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (sce:YPR010C); (R-SCE-73762); (R-SCE-73772)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "11717393;11918799;12145213;12407181;14555487;14562095;14562106;17563356;18160037;18407956;19779198;1990281;22814378;23749301;24153182;24153184;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W421", "ec_number_list": "2.7.7.6;2.7.11.23;5.6.2.3;5.6.2.4", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P22138-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22139-1", "uniprot_id": "RPAB5_YEAST", "mass": 8278.0, "length": 70, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "gene_name": "RPB10", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase core subunit RPB10", "refseq_ac": "NP_014853", "gene_names_uniprotkb": "RPB10", "gene_names_refseq": "RPB10", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC5; ABC10-beta; ABC8; DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide; RNA polymerases I, II, and III subunit ABC5", "protein_names_refseq": "DNA-directed RNA polymerase core subunit RPB10", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR210W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73762); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-76061); (R-SCE-76066); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 20, "publication_count": 27, "publication_id_list": "10384303;11313498;11313499;11805306;12746495;12746498;12914699;14562095;14562106;14580350;14963322;15537538;15591044;15610738;16341226;16765890;16818233;17322287;18160037;22106047;2211663;24153182;24153184;24374639;33491328;8516295;9169874", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0042254 ribosome biogenesis;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P22139-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22146-1", "uniprot_id": "GAS1_YEAST", "mass": 59582.0, "length": 559, "protein_name": "1,3-beta-glucanosyltransferase GAS1", "gene_name": "GAS1", "organism": "Yeast", "refseq_name": "1,3-beta-glucanosyltransferase GAS1", "refseq_ac": "NP_014038", "gene_names_uniprotkb": "GAS1; GGP1; YM9952.09", "gene_names_refseq": "CWH52; GAS1; GGP1", "protein_names_uniprotkb": "1,3-beta-glucanosyltransferase GAS1; 2.4.1.-; Glycolipid-anchored surface protein 1; Glycoprotein GP115", "protein_names_refseq": "1,3-beta-glucanosyltransferase GAS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR307W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10564469;10809732;15355340;15781460;17142567;17617218;1824714;18434410;18468997;2061310;2160276;23749301;24374639;3046936;3072201;31870255;33481703;9169872", "class_list": "", "function": "Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D4;P23151", "ec_number_list": "", "go_molecular_function": "GO:0042124 1,3-beta-glucanosyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0045121 membrane raft;GO:0034399 nuclear periphery", "go_biological_process": "GO:0031507 heterochromatin formation;GO:1905897 regulation of response to endoplasmic reticulum stress;GO:0030447 filamentous growth;GO:0031505 fungal-type cell wall organization;GO:0071970 fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P22146-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22211-1", "uniprot_id": "NPR1_YEAST", "mass": 85990.0, "length": 790, "protein_name": "Nitrogen permease reactivator protein", "gene_name": "NPR1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase NPR1", "refseq_ac": "NP_014216", "gene_names_uniprotkb": "NPR1; N1631", "gene_names_refseq": "NPR1", "protein_names_uniprotkb": "Nitrogen permease reactivator protein; 2.7.11.1; Serine/threonine-protein kinase NPR1", "protein_names_refseq": "serine/threonine protein kinase NPR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL183C); (R-SCE-176187); (R-SCE-5693616); (R-SCE-69601)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "11500493;11741537;11875433;14562106;15247235;16864574;16864577;17330950;17493133;17563356;18407956;18980262;19779198;20489023;20702584;21126336;21177495;2125693;22218487;23749301;24374639;32597660;33229814;33481703;33491328;6343084;9169873;9843498", "class_list": "", "function": "Nutrient-regulated protein kinase that promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression. Under poor nitrogen growth conditions, required for post-Golgi sorting of the general amino acid permease GAP1 and the three known ammonia permeases, MEP1/2/3, to the plasma membrane. Also contributes to the stability and the retention of GAP1 at the plasma membrane. Inversely, promotes the degradation of tryptophan permease TAT2 under the same conditions. Activity is regulated by the TOR signaling pathway via phosphatase SIT4. Although thought to be involved in regulation of GLN3-dependent transcription by nitrogen catabolite repression, this seems to be an indirect effect from the reduced uptake of the nitrogen-repressing compound., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 82, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "D6W103", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.48;2.7.11.13;3.6.4.-;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0090153 regulation of sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P22211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22214-1", "uniprot_id": "SEC22_YEAST", "mass": 25058.0, "length": 214, "protein_name": "Protein transport protein SEC22", "gene_name": "SEC22", "organism": "Yeast", "refseq_name": "SNAP receptor SEC22", "refseq_ac": "NP_013370", "gene_names_uniprotkb": "SEC22; L8479.3; SLY2; TSL26", "gene_names_refseq": "SEC22; SLY2; TS26; TSL26", "protein_names_uniprotkb": "Protein transport protein SEC22; Suppressor of loss of YPT1 protein 2", "protein_names_refseq": "SNAP receptor SEC22", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YLR268W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11001058;12657649;12853481;12893879;12941276;14562106;17322287;18407956;1990290;22814378;24374639;2694679;33491328;9169871", "class_list": "", "function": "Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYR6", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006906 vesicle fusion;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P22214-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22219-1", "uniprot_id": "VPS15_YEAST", "mass": 166372.0, "length": 1454, "protein_name": "Serine/threonine-protein kinase VPS15", "gene_name": "VPS15", "organism": "Yeast", "refseq_name": "ubiquitin-binding serine/threonine protein kinase VPS15", "refseq_ac": "NP_009655", "gene_names_uniprotkb": "VPS15; GRD8; VAC4; VPL19; YBR0825", "gene_names_refseq": "GRD8; VAC4; VPL19; VPS15; VPS40; VPT15", "protein_names_uniprotkb": "Serine/threonine-protein kinase VPS15; 2.7.11.1; Golgi-retention defective mutant protein 8; Vacuolar protein sorting-associated protein 15", "protein_names_refseq": "ubiquitin-binding serine/threonine protein kinase VPS15", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR097W); (R-SCE-1632852); (R-SCE-1660514); (R-SCE-1660516); (R-SCE-1660517); (R-SCE-5668599)", "pathway_count": 6, "publication_count": 22, "publication_id_list": "11157979;12244127;14562095;14562106;1756716;18407956;19445518;1988155;21126336;24165940;24374639;26450213;27630019;28483912;3062374;33491328;7813418;7900426;7989323;8387919;8509446;8649377", "class_list": "", "function": "Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (PubMed:11157979). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (PubMed:11157979, PubMed:1756716, PubMed:1988155, PubMed:7989323). Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (PubMed:11157979, PubMed:12244127, PubMed:8649377). This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes) (PubMed:12244127, PubMed:7989323, PubMed:8387919, PubMed:8509446, PubMed:8649377). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole (PubMed:8387919, PubMed:8509446). May function as a G protein beta subunit to propagate the pheromone response at the endosome with GPA1 (PubMed:19445518)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ98", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.1.137;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0043130 ubiquitin binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005770 late endosome;GO:0010008 endosome membrane", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0045053 protein retention in Golgi apparatus;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0000011 vacuole inheritance", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P22219-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22543-1", "uniprot_id": "VPS34_YEAST", "mass": 100921.0, "length": 875, "protein_name": "Phosphatidylinositol 3-kinase VPS34", "gene_name": "VPS34", "organism": "Yeast", "refseq_name": "phosphatidylinositol 3-kinase VPS34", "refseq_ac": "NP_013341", "gene_names_uniprotkb": "VPS34; END12; L9672.10; PEP15; VPL7; VPT29", "gene_names_refseq": "END12; PEP15; STT8; VPL7; VPS34; VPS7; VPT29", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase VPS34; 2.7.1.137; Carboxypeptidase Y-deficient protein 15; PI3-kinase VPS34; PI3K VPS34; PtdIns-3-kinase VPS34; Vacuolar protein sorting-associated protein 34; Vacuolar protein-targeting protein 29", "protein_names_refseq": "phosphatidylinositol 3-kinase VPS34", "tax_id": 559292, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YLR240W); (R-SCE-1632852); (R-SCE-1660514); (R-SCE-1660516); (R-SCE-1660517); (R-SCE-5668599)", "pathway_count": 6, "publication_count": 25, "publication_id_list": "11157979;11523784;12244127;14562095;14562106;19684113;2247081;23749301;24165940;24374639;2555343;26450213;26510498;27630019;28483912;29698392;3062374;33229814;33491328;34965436;7929582;7989323;8385367;8387919;9169871", "class_list": "", "function": "Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VYN8", "ec_number_list": "2.7.11.1;2.7.1.137", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005777 peroxisome", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly;GO:0006897 endocytosis;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P22543-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22696-1", "uniprot_id": "ESS1_YEAST", "mass": 19405.0, "length": 170, "protein_name": "Peptidyl-prolyl cis-trans isomerase ESS1", "gene_name": "ESS1", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase ESS1", "refseq_ac": "NP_012551", "gene_names_uniprotkb": "ESS1; J1452; PIN1; PTF1", "gene_names_refseq": "ESS1; PIN1; PTF1", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase ESS1; 5.2.1.8; PPIase ESS1; Parvulin ESS1; Processing/termination factor 1", "protein_names_refseq": "peptidylprolyl isomerase ESS1", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); secondary hyperparathyroidism (Disease Ontology:DOID:12466); asthma (Disease Ontology:DOID:2841)", "pathway": " (sce:YJR017C); (R-SCE-5668599); (R-SCE-6811555)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10531363;10899127;12748633;14562095;14562106;15728580;18407956;24374639;2648698;30516470;33491328;7781779;8641269;9558330;9867817", "class_list": "", "function": "Essential PPIase specific for phosphoserine and phosphothreonine N-terminal to the proline residue. Required for efficient pre-mRNA 3'-end processing and transcription termination, probably by inducing conformational changes by proline-directed isomerization in the C-terminal domain (CTD) of RPB1, thereby altering cofactor binding with the RNA polymerase II transcription complex. Also targets the SIN3-RPD3 histone deacetylase complex (HDAC)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWJ3", "ec_number_list": "5.2.1.8;2.7.11.13;2.7.1.68", "go_molecular_function": "GO:0000993 RNA polymerase II complex binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0006369 termination of RNA polymerase II transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P22696-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23287-1", "uniprot_id": "PP2B1_YEAST", "mass": 63002.0, "length": 553, "protein_name": "Serine/threonine-protein phosphatase 2B catalytic subunit A1", "gene_name": "CNA1", "organism": "Yeast", "refseq_name": "calcineurin catalytic subunit A", "refseq_ac": "NP_013537", "gene_names_uniprotkb": "CNA1; CMP1; L9753.6", "gene_names_refseq": "CMP1; CNA1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2B catalytic subunit A1; 3.1.3.16; Calcineurin A1; Calmodulin-binding protein 1", "protein_names_refseq": "calcineurin catalytic subunit A", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); aortic valve stenosis (Disease Ontology:DOID:1712); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": " (sce:YLR433C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1311678;14562106;1646387;1651503;17322287;20489023;22814378;23749301;24374639;33491328;9169871", "class_list": "", "function": "Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ68", "ec_number_list": "3.1.3.16;3.1.3.43;3.1.3.48", "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0045893 positive regulation of DNA-templated transcription;GO:0022604 regulation of cell morphogenesis;GO:0006873 intracellular monoatomic ion homeostasis;GO:0071444 cellular response to pheromone", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P23287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23291-1", "uniprot_id": "KC11_YEAST", "mass": 61715.0, "length": 538, "protein_name": "Casein kinase I homolog 1", "gene_name": "YCK1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase YCK1", "refseq_ac": "NP_012003", "gene_names_uniprotkb": "YCK1; CKI2", "gene_names_refseq": "CKI2; YCK1", "protein_names_uniprotkb": "Casein kinase I homolog 1; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase YCK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR135C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10866691;12370247;14562106;1627830;16823961;1729698;17322287;17330950;17563356;18407956;19684113;19779198;20489023;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8091229;9491083", "class_list": "", "function": "Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D3DL84;E9P958", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0000902 cell morphogenesis;GO:0009749 response to glucose;GO:0010255 glucose mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P23291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24583-1", "uniprot_id": "KPC1_YEAST", "mass": 131477.0, "length": 1151, "protein_name": "Protein kinase C-like 1", "gene_name": "PKC1", "organism": "Yeast", "refseq_name": "protein kinase C", "refseq_ac": "NP_009445", "gene_names_uniprotkb": "PKC1; HPO2; STT1; YBL0807", "gene_names_refseq": "CLY15; CLY5; CLY7; HPO2; PKC1; RSF8; STT1", "protein_names_uniprotkb": "Protein kinase C-like 1; 2.7.11.13; PKC 1", "protein_names_refseq": "protein kinase C", "tax_id": 559292, "disease": "spinocerebellar ataxia 14 (Disease Ontology:DOID:0050964); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); muscular disease (Disease Ontology:DOID:0080000); autoimmune lymphoproliferative syndrome type 3 (Disease Ontology:DOID:0110119); prostate carcinoma (Disease Ontology:DOID:10286); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); hyperinsulinism (Disease Ontology:DOID:2018); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); middle cerebral artery infarction (Disease Ontology:DOID:3525); chordoid glioma (Disease Ontology:DOID:3774); lung non-small cell carcinoma (Disease Ontology:DOID:3908); restrictive cardiomyopathy (Disease Ontology:DOID:397); ovarian carcinoma (Disease Ontology:DOID:4001); hyperglycemia (Disease Ontology:DOID:4195); large cell carcinoma (Disease Ontology:DOID:4552); retinal detachment (Disease Ontology:DOID:5327); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YBL105C); (R-SCE-114508); (R-SCE-114516); (R-SCE-1169091); (R-SCE-1489509); (R-SCE-202424); (R-SCE-2029485); (R-SCE-2179392); (R-SCE-2871837); (R-SCE-399997); (R-SCE-4419969); (R-SCE-5218921); (R-SCE-5607764); (R-SCE-5625740); (R-SCE-5668599); (R-SCE-6798695); (R-SCE-76005); (R-SCE-8980692); (R-SCE-9013106); (R-SCE-9634635); (R-SCE-9856530)", "pathway_count": 21, "publication_count": 20, "publication_id_list": "10074427;10567559;15470109;17563356;18407956;19684113;19779198;19795423;19823750;20489023;2196995;23749301;24374639;25624345;32597660;33481703;33491328;7502586;7813418;9133734", "class_list": "", "function": "Required for cell growth and for the G2->M transition of the cell division cycle. Mediates a protein kinase cascade; it activates BCK1 which itself activates MKK1/MKK2., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 51, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPP8", "ec_number_list": "2.7.11.22;3.5.3.1;2.7.11.11;2.7.11.1;2.4.1.1;3.6.5.2;2.7.12.2;2.7.12.1;2.7.11.24;1.6.2.4;2.7.11.17;5.2.1.8;2.7.11.23;2.7.11.25;3.1.3.48;2.7.11.13;3.6.4.6;3.1.26.-;2.7.11.21;2.7.1.67;1.11.1.27;1.11.1.25;3.1.4.4;1.1.1.205;3.4.-.-;3.6.-.-;3.6.4.-;4.6.1.19;3.-.-.-;2.7.1.91;3.6.1.-;5.3.4.1", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0009267 cellular response to starvation;GO:0034063 stress granule assembly;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P24583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24784-1", "uniprot_id": "DBP1_YEAST", "mass": 67917.0, "length": 617, "protein_name": "ATP-dependent RNA helicase DBP1", "gene_name": "DBP1", "organism": "Yeast", "refseq_name": "putative DEAD-box ATP-dependent RNA helicase DBP1", "refseq_ac": "NP_015206", "gene_names_uniprotkb": "DBP1; LPH8C", "gene_names_refseq": "DBP1; LPH8", "protein_names_uniprotkb": "ATP-dependent RNA helicase DBP1; 3.6.4.13; DEAD box protein 1; Helicase CA1", "protein_names_refseq": "putative DEAD-box ATP-dependent RNA helicase DBP1", "tax_id": 559292, "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YPL119C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;14763975;1857205;2406722;24374639;9169875", "class_list": "", "function": "ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Redundant to DED1, may be required in conditions in which DED1 expression is decreased., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3P9;P20446", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation;GO:1901195 positive regulation of formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P24784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25293-1", "uniprot_id": "NAP1_YEAST", "mass": 47885.0, "length": 417, "protein_name": "Nucleosome assembly protein", "gene_name": "NAP1", "organism": "Yeast", "refseq_name": "histone chaperone NAP1", "refseq_ac": "NP_012974", "gene_names_uniprotkb": "NAP1", "gene_names_refseq": "NAP1", "protein_names_uniprotkb": "Nucleosome assembly protein; Histone H2A-H2B chaperone NAP1; Protein chaperone NAP1; Ribosome assembly chaperone NAP1", "protein_names_refseq": "histone chaperone NAP1", "tax_id": 559292, "disease": "appendiceal neoplasm (Disease Ontology:DOID:11240); pancreatic cancer (Disease Ontology:DOID:1793); hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (sce:YKR048C)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "12058072;14562095;14562106;15665377;16432217;17322287;17330950;17563356;18068721;18086883;18407956;19684113;19779198;19795423;19823750;2016313;20489023;20702584;21126336;21177495;22106047;22218487;23749301;24374639;27036862;27225933;30516470;31062022;32597660;33481703;33491328;34536244;39601790;7622566;8196765", "class_list": "", "function": "Histone H2A-H2B chaperone that together with karyopherin KAP114 co-chaperones histone H2A-H2B dimers into the nucleus; subsequent binding of RAN(GTP) GSP1 to this complex promotes specific and accurate deposition of H2A-H2B into nucleosomes (PubMed:18086883, PubMed:2016313, PubMed:27225933). Also acts as an assembly chaperone for the small ribosomal subunit protein eS6 (RPS6A and RPS6B), thereby functioning in 40S ribosomal subunit biogenesis (PubMed:31062022). May also chaperone the large ribosomal subunit proteins eL39 and eL42 (PubMed:31062022). Plays a role in the regulation of the cell cycle; regulates the localization and function of septins during mitosis, and the function of B-type cyclins (PubMed:12058072, PubMed:18086883, PubMed:7622566)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXA9;P87196", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032153 cell division site", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0006334 nucleosome assembly;GO:0031116 positive regulation of microtubule polymerization;GO:0000921 septin ring assembly;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P25293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25294-1", "uniprot_id": "SIS1_YEAST", "mass": 37590.0, "length": 352, "protein_name": "Protein SIS1", "gene_name": "SIS1", "organism": "Yeast", "refseq_name": "type II HSP40 co-chaperone SIS1", "refseq_ac": "NP_014391", "gene_names_uniprotkb": "SIS1; N2879", "gene_names_refseq": "SIS1", "protein_names_uniprotkb": "Protein SIS1", "protein_names_refseq": "type II HSP40 co-chaperone SIS1", "tax_id": 559292, "disease": "congenital myopathy 21 (Disease Ontology:DOID:0081353); autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305); primary ciliary dyskinesia 34 (Disease Ontology:DOID:0110610); distal myopathy (Disease Ontology:DOID:11720)", "pathway": " (sce:YNL007C); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "11279042;14562095;14562106;15665377;1714460;18407956;19779198;21126336;23749301;24374639;33481703;33491328;8513501;9169873", "class_list": "", "function": "Required for nuclear migration during mitosis. It is required for the normal initiation of translation. Might mediate the dissociation of a specific protein complex of the translation machinery. Essential for viability., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1H0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0034605 cellular response to heat;GO:0006413 translational initiation;GO:0006457 protein folding;GO:0009267 cellular response to starvation;GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P25294-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25302-1", "uniprot_id": "SWI4_YEAST", "mass": 123806.0, "length": 1093, "protein_name": "Regulatory protein SWI4", "gene_name": "SWI4", "organism": "Yeast", "refseq_name": "SBF complex DNA-binding subunit SWI4", "refseq_ac": "NP_011036", "gene_names_uniprotkb": "SWI4; ART1", "gene_names_refseq": "ART1; SWI4", "protein_names_uniprotkb": "Regulatory protein SWI4; Cell-cycle box factor subunit SWI4; Protein ART1", "protein_names_refseq": "SBF complex DNA-binding subunit SWI4", "tax_id": 559292, "disease": "", "pathway": " (sce:YER111C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11875433;14562106;15665377;17287358;18160399;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22031224;23749301;24374639;2689885;32597660;33229814;33481703;33491328;8355657;9169868", "class_list": "", "function": "Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D3DM17", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0030907 MBF transcription complex;GO:0033309 SBF transcription complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0034605 cellular response to heat;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P25302-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25454-1", "uniprot_id": "RAD51_YEAST", "mass": 42963.0, "length": 400, "protein_name": "DNA repair protein RAD51", "gene_name": "RAD51", "organism": "Yeast", "refseq_name": "recombinase RAD51", "refseq_ac": "NP_011021", "gene_names_uniprotkb": "RAD51", "gene_names_refseq": "MUT5; RAD51", "protein_names_uniprotkb": "DNA repair protein RAD51; 3.6.4.-", "protein_names_refseq": "recombinase RAD51", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); mirror movements 2 (Disease Ontology:DOID:0070637); Fanconi anemia complementation group R (Disease Ontology:DOID:0111090); hypertension (Disease Ontology:DOID:10763); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); primary ovarian insufficiency (Disease Ontology:DOID:5426); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YER095W); (R-SCE-5693616)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10970884;14562106;15235592;1581961;1620127;1620128;16818607;18471978;20371520;22031224;22955832;24374639;32083180;32652040;33491328;39898551;7634335;8066464;9169868;9590697", "class_list": "", "function": "Homologous DNA recombinase that catalyzes strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:14562106, PubMed:1581961, PubMed:20371520, PubMed:7634335, PubMed:8066464). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:14562106, PubMed:1581961, PubMed:20371520, PubMed:7634335, PubMed:8066464). Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (PubMed:14562106, PubMed:20371520, PubMed:22955832, PubMed:7634335, PubMed:8066464). RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis (PubMed:20371520). Also required for homologous recombination during meiosis by acting as an non-catalytic accessory factor for DMC1 recombinase, enabling proper chromosome pairing and crossing over (PubMed:22955832)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM03", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;2.7.11.1;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;7.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005759 mitochondrial matrix;GO:0000228 nuclear chromosome;GO:0000262 mitochondrial chromosome", "go_biological_process": "GO:0006312 mitotic recombination;GO:0006310 DNA recombination;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006302 double-strand break repair;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P25454-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25638-1", "uniprot_id": "TAH1_YEAST", "mass": 12511.0, "length": 111, "protein_name": "TPR repeat-containing protein associated with Hsp90", "gene_name": "TAH1", "organism": "Yeast", "refseq_name": "Tah1p", "refseq_ac": "NP_009986", "gene_names_uniprotkb": "TAH1; YCR60W", "gene_names_refseq": "TAH1", "protein_names_uniprotkb": "TPR repeat-containing protein associated with Hsp90", "protein_names_refseq": "Tah1p", "tax_id": 559292, "disease": "autosomal recessive spinocerebellar ataxia 16 (Disease Ontology:DOID:0080029); cerebellar ataxia type 48 (Disease Ontology:DOID:0111746)", "pathway": " (sce:YCR060W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;1574125;15766533;17322287;22814378;24374639;33491328", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR65", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0000492 box C/D snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P25638-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25655-1", "uniprot_id": "NOT1_YEAST", "mass": 240279.0, "length": 2108, "protein_name": "General negative regulator of transcription subunit 1", "gene_name": "CDC39", "organism": "Yeast", "refseq_name": "CCR4-NOT core subunit CDC39", "refseq_ac": "NP_010017", "gene_names_uniprotkb": "CDC39; NOT1; ROS1; YCR1151; YCR93W", "gene_names_refseq": "CDC39; NOT1; ROS1; SMD6", "protein_names_uniprotkb": "General negative regulator of transcription subunit 1; Cell division cycle protein 39", "protein_names_refseq": "CCR4-NOT core subunit CDC39", "tax_id": 559292, "disease": "Vissers-Bodmer syndrome (Disease Ontology:DOID:0081397); holoprosencephaly 12 (Disease Ontology:DOID:0081398); heart disease (Disease Ontology:DOID:114)", "pathway": " (sce:YCR093W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10490603;11733989;11875433;11889048;14562106;15665377;1574125;18407956;19779198;19795423;19823750;20386698;20702584;22218487;23749301;24374639;32597660;33481703;33491328;7926748;8428577;9463387", "class_list": "", "function": "Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR93", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0017148 negative regulation of translation;GO:0006368 transcription elongation by RNA polymerase II;GO:0051726 regulation of cell cycle;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P25655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25693-1", "uniprot_id": "PCL2_YEAST", "mass": 35207.0, "length": 308, "protein_name": "PHO85 cyclin-2", "gene_name": "PCL2", "organism": "Yeast", "refseq_name": "cyclin PCL2", "refseq_ac": "NP_010156", "gene_names_uniprotkb": "PCL2; CLN4; D2223", "gene_names_refseq": "CLN4; PCL2", "protein_names_uniprotkb": "PHO85 cyclin-2; Cyclin HCS26 homolog; G1/S-specific cyclin PCL2", "protein_names_refseq": "cyclin PCL2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL127W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12748633;12857883;14688790;15598647;1860879;24374639;33491328;7973731;9032248;9169867;9529390;9843683", "class_list": "", "function": "G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. Together with cyclin PCL1, positively controls degradation of sphingoid long chain base kinase LCB4. The PCL2-PHO85 cyclin-CDK holoenzyme phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM3;Q07554", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0000131 incipient cellular bud site;GO:0005934 cellular bud tip", "go_biological_process": "GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0001676 long-chain fatty acid metabolic process;GO:0051301 cell division;GO:0051726 regulation of cell cycle;GO:0044843 cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P25693-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25694-1", "uniprot_id": "CDC48_YEAST", "mass": 91996.0, "length": 835, "protein_name": "AAA family ATPase involved in ubiquitin-mediated protein degradation CDC48", "gene_name": "CDC48", "organism": "Yeast", "refseq_name": "AAA family ATPase CDC48", "refseq_ac": "NP_010157", "gene_names_uniprotkb": "CDC48", "gene_names_refseq": "CDC48", "protein_names_uniprotkb": "AAA family ATPase involved in ubiquitin-mediated protein degradation CDC48; 3.6.4.6; Cell division control protein 48; Cell division cycle protein 48; Transitional endoplasmic reticulum ATPase homolog", "protein_names_refseq": "AAA family ATPase CDC48", "tax_id": 559292, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (Disease Ontology:DOID:0060205); Charcot-Marie-Tooth disease type 2Y (Disease Ontology:DOID:0110168); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 (Disease Ontology:DOID:0111385); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); inclusion body myositis (Disease Ontology:DOID:3429); Paget's disease of bone (Disease Ontology:DOID:5408); primary ovarian insufficiency (Disease Ontology:DOID:5426); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (sce:YDL126C); (R-SCE-3371511); (R-SCE-5689896); (R-SCE-6798695); (R-SCE-8876725); (R-SCE-8951664); (R-SCE-9755511)", "pathway_count": 7, "publication_count": 54, "publication_id_list": "11598205;11733065;11740563;11813000;11847109;12872131;14562106;14636562;15258615;15665377;16427015;16428438;16873066;17287358;17330950;17563356;18407956;1860879;19684113;19779198;19795423;19805280;19823750;20489023;20508643;20702584;21070972;21126336;21148305;21177495;21454554;22106047;22218487;22814378;23178123;23479637;23749301;24155900;24261871;24374639;24909858;26928762;27044889;29355480;30516470;31249134;31249135;31445887;32597660;33481703;33491328;34965436;6749598;9169867", "class_list": "", "function": "ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates (PubMed:21454554, PubMed:31445887). By recruiting and promoting the degradation of ubiquitinated proteins, plays a role in the ubiquitin fusion degradation (UFD) pathway (PubMed:16428438). Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway which mediates the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:11740563, PubMed:11813000, PubMed:11847109, PubMed:21148305). Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1 (PubMed:11733065, PubMed:11847109). Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD (PubMed:11847109). Regulates ubiquitin-mediated mitochondria protein degradation (PubMed:21070972, PubMed:27044889). Involved in spindle disassembly probably by promoting the degradation of spindle assembly factors ASE1 and CDC5 at the end of mitosis (PubMed:14636562). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123, PubMed:24261871). CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel (PubMed:23178123, PubMed:24261871). Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation (PubMed:20508643). Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:29355480). Substrate initially binds through the attached polyubiquitin chain to UDF1/NPL4 and then moves through the pore of the ATPase rings and is thereby unfolded (PubMed:31249134, PubMed:31249135). Acts on a broad range of even well-folded proteins via ubiquitin-binding and unfolding to initiate substrate processing (PubMed:31249135). Involved in degradation of mislocalized tail-anchored transmembrane proteins extracted from the mitochondrion outer membrane by MSP1 and ubiquitinated by DOA10 (PubMed:31445887)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM4", "ec_number_list": "2.7.1.40;3.5.3.1;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;5.6.2.3;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;3.6.-.-;5.6.2.4;5.2.1.8;1.11.1.6;3.5.4.6;3.6.4.-;2.7.1.11;5.6.1.4;2.7.1.2;1.1.1.42;3.6.4.12;2.7.11.13;3.4.25.1;3.6.4.6;5.6.2.5;3.6.5.-;2.7.11.24;3.6.1.-;2.3.2.27;5.4.2.2;1.11.1.27;1.11.1.25;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;3.1.-.-;3.4.24.-;2.7.1.35;3.4.19.12;2.4.2.7;3.5.1.98;4.6.1.19;5.4.2.7;2.3.2.26;3.-.-.-;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;2.7.4.3;2.7.11.1;2.1.1.-;7.2.2.-;5.3.4.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0030894 replisome;GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0097352 autophagosome maturation;GO:0010636 positive regulation of mitochondrial fusion;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0043335 protein unfolding", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P25694-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27616-1", "uniprot_id": "PUR7_YEAST", "mass": 34603.0, "length": 306, "protein_name": "Phosphoribosylaminoimidazole-succinocarboxamide synthase", "gene_name": "ADE1", "organism": "Yeast", "refseq_name": "phosphoribosylaminoimidazolesuccinocarboxamide synthase", "refseq_ac": "NP_009409", "gene_names_uniprotkb": "ADE1", "gene_names_refseq": "ADE1", "protein_names_uniprotkb": "Phosphoribosylaminoimidazole-succinocarboxamide synthase; 6.3.2.6; SAICAR synthetase", "protein_names_refseq": "phosphoribosylaminoimidazolesuccinocarboxamide synthase", "tax_id": 559292, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YAR015W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;1495480;1658741;1756975;18407956;22814378;24374639;3013210;33491328;7731988;7941740;9551557", "class_list": "", "function": "Catalyzes the reaction of 4-carboxy-5-aminoimidazole ribotide (CAIR) and aspartic acid with the formation of N-succinyl-5-amino-imidazole-4-carboxamide ribotide (SAICAR) in the purine biosynthesis pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPM4", "ec_number_list": "6.3.2.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P27616-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27692-1", "uniprot_id": "SPT5_YEAST", "mass": 115650.0, "length": 1063, "protein_name": "Transcription elongation factor SPT5", "gene_name": "SPT5", "organism": "Yeast", "refseq_name": "transcription elongation factor SPT5", "refseq_ac": "NP_013703", "gene_names_uniprotkb": "SPT5; YM9571.08", "gene_names_refseq": "SPT5", "protein_names_uniprotkb": "Transcription elongation factor SPT5; Chromatin elongation factor SPT5", "protein_names_refseq": "transcription elongation factor SPT5", "tax_id": 559292, "disease": "", "pathway": " (sce:YML010W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6796648); (R-SCE-72086); (R-SCE-77075)", "pathway_count": 6, "publication_count": 37, "publication_id_list": "12554661;12556496;14562106;14576278;14668364;15780939;16172632;17287358;17563356;1840633;18407956;19581288;19683497;19684113;19779198;20489023;20702584;20713510;22290438;22796944;23749301;24374639;26217010;27376968;30516470;31462158;32597660;33229814;33481703;33491328;33846633;37939109;38538796;39424994;39438667;9169872;9450930", "class_list": "", "function": "Component of the SPT4-SPT5 (DISF) complex that manipulates multiple stages of transcription from promoter- proximal pausing (PPP) to termination (PubMed:12556496, PubMed:33846633, PubMed:38538796, PubMed:39424994, PubMed:9450930). Mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing (PubMed:12556496, PubMed:16172632, PubMed:33846633, PubMed:38538796, PubMed:39424994, PubMed:9450930). Binds to single stranded RNA containing AAN repeats in a sequence-specific manner (PubMed:27376968). The complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (PubMed:12554661, PubMed:15780939, PubMed:39438667). SPT5 is finely balancing the bidirectionality of transcription, and SPT5-mediated suppression of SPT4-SPT5 complex regulated-unstable transcripts is essential to sustain the accurate transcription by RNA polymerase II (PubMed:39438667). Finally, the SPT4-SPT5 complex also negatively regulates the expression of ATG8 and ATG41, inhibiting autophagy activity during active growth. Under autophagy-inducing conditions, the repression is released by SPT5 phosphorylation, allowing an up-regulation of autophagy activity (PubMed:31462158)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 63, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VZG4", "ec_number_list": "", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0030620 U2 snRNA binding;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0032044 DSIF complex;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000785 chromatin;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:2000232 regulation of rRNA processing;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0010508 positive regulation of autophagy;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P27692-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27705-1", "uniprot_id": "MIG1_YEAST", "mass": 55532.0, "length": 504, "protein_name": "Regulatory protein MIG1", "gene_name": "MIG1", "organism": "Yeast", "refseq_name": "transcription factor MIG1", "refseq_ac": "NP_011480", "gene_names_uniprotkb": "MIG1; CAT4; SSN1", "gene_names_refseq": "CAT4; MIG1; SSN1; TDS22", "protein_names_uniprotkb": "Regulatory protein MIG1; Regulatory protein CAT4", "protein_names_refseq": "transcription factor MIG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL035C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10403407;10556086;14562106;15665377;17178716;17322287;17330950;17563356;18407956;19684113;19779198;20702584;20815814;21177495;2167835;22218487;23749301;24374639;28841133;30516470;32597660;32973189;33229814;33481703;33491328;34965436;9169869;9523726;9774644", "class_list": "", "function": "Involved in glucose repression of the SUC, GAL and MAL genes as well as of the CAT8 gene. Binds to two sites in the upstream region of SUC2., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 47, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VUA4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P27705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27801-1", "uniprot_id": "PEP3_YEAST", "mass": 107398.0, "length": 918, "protein_name": "Vacuolar membrane protein PEP3", "gene_name": "PEP3", "organism": "Yeast", "refseq_name": "tethering complex subunit PEP3", "refseq_ac": "NP_013249", "gene_names_uniprotkb": "PEP3; L9634.2; VAM8; VPS18; VPT18", "gene_names_refseq": "PEP3; VAM8; VPS18; VPT18", "protein_names_uniprotkb": "Vacuolar membrane protein PEP3; Carboxypeptidase Y-deficient protein 3; Vacuolar morphogenesis protein 8; Vacuolar protein sorting-associated protein 18; Vacuolar protein-targeting protein 18", "protein_names_refseq": "tethering complex subunit PEP3", "tax_id": 559292, "disease": "cholestasis (Disease Ontology:DOID:13580)", "pathway": " (sce:YLR148W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10978279;14562106;16601699;1840635;18407956;1944264;19779198;19795423;19823750;21126336;22218487;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as a component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYE3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0033263 CORVET complex", "go_biological_process": "GO:0048284 organelle fusion;GO:0035542 regulation of SNARE complex assembly;GO:0042144 vacuole fusion, non-autophagic;GO:0006886 intracellular protein transport;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P27801-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28000-1", "uniprot_id": "RPAC2_YEAST", "mass": 16151.0, "length": 142, "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC2", "gene_name": "RPC19", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase core subunit RPC19", "refseq_ac": "NP_014286", "gene_names_uniprotkb": "RPC19; N1937", "gene_names_refseq": "RPC19", "protein_names_uniprotkb": "DNA-directed RNA polymerases I and III subunit RPAC2; AC19; DNA-directed RNA polymerases I and III 16 kDa polypeptide; RNA polymerases I and III subunit AC2; RPA19", "protein_names_refseq": "DNA-directed RNA polymerase core subunit RPC19", "tax_id": 559292, "disease": "Treacher Collins syndrome 2 (Disease Ontology:DOID:0080790); leukodystrophy (Disease Ontology:DOID:10579); Treacher Collins syndrome (Disease Ontology:DOID:2908); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YNL113W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10384303;11717393;14562095;14562106;16818233;17322287;17330950;17563356;18084032;18160037;18407956;1869554;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22106047;23749301;24153182;24153184;24374639;30516470;32597660;33481703;33491328;8516295;9090055;9169873", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W168", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P28000-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28519-1", "uniprot_id": "RAD14_YEAST", "mass": 43038.0, "length": 371, "protein_name": "DNA repair protein RAD14", "gene_name": "RAD14", "organism": "Yeast", "refseq_name": "DNA repair protein RAD14", "refseq_ac": "NP_013928", "gene_names_uniprotkb": "RAD14; YM8325.02C", "gene_names_refseq": "RAD14", "protein_names_uniprotkb": "DNA repair protein RAD14", "protein_names_refseq": "DNA repair protein RAD14", "tax_id": 559292, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843)", "pathway": " (sce:YMR201C); (R-SCE-6782135)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;1741034;20489023;22814378;24374639;26100901;33491328;8516285;8621533;9046084;9169872", "class_list": "", "function": "Involved in nucleotide excision repair. Binds specifically to damaged DNA. Required for the incision step., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W026", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0005634 nucleus", "go_biological_process": "GO:0006284 base-excision repair;GO:0006974 DNA damage response;GO:0070914 UV-damage excision repair;GO:0000715 nucleotide-excision repair, DNA damage recognition;GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P28519-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28707-1", "uniprot_id": "SBA1_YEAST", "mass": 24082.0, "length": 216, "protein_name": "Co-chaperone protein SBA1", "gene_name": "SBA1", "organism": "Yeast", "refseq_name": "Hsp90 cochaperone SBA1", "refseq_ac": "NP_012805", "gene_names_uniprotkb": "SBA1; YKL518", "gene_names_refseq": "CST18; SBA1", "protein_names_uniprotkb": "Co-chaperone protein SBA1", "protein_names_refseq": "Hsp90 cochaperone SBA1", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); oligodendroglioma (Disease Ontology:DOID:3181)", "pathway": " (sce:YKL117W); (R-SCE-2162123); (R-SCE-3371511); (R-SCE-8939211)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10691735;14562106;1561835;16625188;24374639;33481703;33491328;8196765;9298649", "class_list": "", "function": "Acts as a co-chaperone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXH2", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P28707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29366-1", "uniprot_id": "BEM1_YEAST", "mass": 61605.0, "length": 551, "protein_name": "Bud emergence protein 1", "gene_name": "BEM1", "organism": "Yeast", "refseq_name": "phosphatidylinositol-3-phosphate-binding protein BEM1", "refseq_ac": "NP_009759", "gene_names_uniprotkb": "BEM1; SRO1; YBR1412", "gene_names_refseq": "BEM1; SRO1", "protein_names_uniprotkb": "Bud emergence protein 1; Suppressor of RHO3 protein 1", "protein_names_refseq": "phosphatidylinositol-3-phosphate-binding protein BEM1", "tax_id": 559292, "disease": "autosomal recessive chronic granulomatous disease 3 (Disease Ontology:DOID:0070194); Frank-Ter Haar syndrome (Disease Ontology:DOID:0111789); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (sce:YBR200W); (R-SCE-5668599)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "11483498;14562106;1538785;15665377;16230527;16854988;17330950;17460121;17563356;18407956;1905981;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22814378;23749301;24374639;24909858;30516470;32597660;33481703;33491328;7813418;7975899", "class_list": "", "function": "Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQJ6", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:1902494 catalytic complex", "go_biological_process": "GO:0035023 regulation of Rho protein signal transduction;GO:0045185 maintenance of protein location;GO:0000282 cellular bud site selection;GO:0000747 conjugation with cellular fusion;GO:0000753 cell morphogenesis involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P29366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29469-1", "uniprot_id": "MCM2_YEAST", "mass": 98780.0, "length": 868, "protein_name": "DNA replication licensing factor MCM2", "gene_name": "MCM2", "organism": "Yeast", "refseq_name": "MCM DNA helicase complex subunit MCM2", "refseq_ac": "NP_009530", "gene_names_uniprotkb": "MCM2; YBL0438", "gene_names_refseq": "MCM2", "protein_names_uniprotkb": "DNA replication licensing factor MCM2; 3.6.4.12; Minichromosome maintenance protein 2", "protein_names_refseq": "MCM DNA helicase complex subunit MCM2", "tax_id": 559292, "disease": "autosomal dominant nonsyndromic deafness 70 (Disease Ontology:DOID:0110592); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (sce:YBL023C); (R-SCE-176187); (R-SCE-68867); (R-SCE-68962); (R-SCE-69052)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "14562106;18657510;19692334;19779198;19896182;19910535;2044961;21070963;22564307;23749301;24374639;26582917;28510759;33481703;33491328;7725803;7813418;8276800", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Necessary for cell growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPX7", "ec_number_list": "2.7.11.22;2.7.11.1;3.6.4.13;5.6.2.3;3.6.4.10;2.7.7.-;3.6.-.-;5.6.2.4;2.7.7.7;3.6.4.-;5.6.1.4;3.1.11.-;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;7.2.2.-", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0031261 DNA replication preinitiation complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:1902975 mitotic DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P29469-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29539-1", "uniprot_id": "RIF1_YEAST", "mass": 217931.0, "length": 1916, "protein_name": "Telomere length regulator protein RIF1", "gene_name": "RIF1", "organism": "Yeast", "refseq_name": "DNA-binding protein RIF1", "refseq_ac": "NP_009834", "gene_names_uniprotkb": "RIF1; YBR1743", "gene_names_refseq": "RIF1", "protein_names_uniprotkb": "Telomere length regulator protein RIF1; RAP1-interacting factor 1", "protein_names_refseq": "DNA-binding protein RIF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR275C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10531008;12589054;15572688;1577274;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20489023;21126336;23749301;24374639;25329891;30516470;32597660;33481703;33491328;33772576;7813418;7867933;8091861;9087429;9710643", "class_list": "", "function": "Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 58, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS1;P89507", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0042162 telomeric DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0019237 centromeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070187 shelterin complex;GO:0000781 chromosome, telomeric region;GO:0140445 chromosome, telomeric repeat region", "go_biological_process": "GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0070198 protein localization to chromosome, telomeric region;GO:0097752 regulation of DNA stability;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P29539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30283-1", "uniprot_id": "CGS5_YEAST", "mass": 50431.0, "length": 435, "protein_name": "S-phase entry cyclin-5", "gene_name": "CLB5", "organism": "Yeast", "refseq_name": "B-type cyclin CLB5", "refseq_ac": "NP_015445", "gene_names_uniprotkb": "CLB5; P9642.8", "gene_names_refseq": "CLB5", "protein_names_uniprotkb": "S-phase entry cyclin-5", "protein_names_refseq": "B-type cyclin CLB5", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (sce:YPR120C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1387626;14562106;18407956;20489023;23749301;24374639;33491328;8253070;8319908;9169875", "class_list": "", "function": "Required for efficient progression through S phase and possibly for the normal progression through meiosis. Interacts with CDC28., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4B9", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006355 regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P30283-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31244-1", "uniprot_id": "RAD16_YEAST", "mass": 91430.0, "length": 790, "protein_name": "DNA repair protein RAD16", "gene_name": "RAD16", "organism": "Yeast", "refseq_name": "DNA repair protein RAD16", "refseq_ac": "NP_009672", "gene_names_uniprotkb": "RAD16; YBR0909", "gene_names_refseq": "PSO5; RAD16", "protein_names_uniprotkb": "DNA repair protein RAD16; 3.6.4.-; ATP-dependent helicase RAD16", "protein_names_refseq": "DNA repair protein RAD16", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR114W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10601031;14562106;1508678;15177043;1626430;1626431;17330950;17563356;18407956;19779198;19795423;19823750;19920177;20702584;21126336;21177495;22218487;23749301;24374639;27821475;30516470;32597660;33481703;33491328;33502312;7813418", "class_list": "", "function": "Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. Involved in differential repair of DNA after UV damage. Will repair preferentially the MAT-alpha locus compared with the HML-alpha locus., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQB3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0000113 nucleotide-excision repair factor 4 complex", "go_biological_process": "GO:0009411 response to UV;GO:0008104 intracellular protein localization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0034644 cellular response to UV;GO:0000715 nucleotide-excision repair, DNA damage recognition", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P31244-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32264-1", "uniprot_id": "PROB_YEAST", "mass": 47162.0, "length": 428, "protein_name": "Glutamate 5-kinase", "gene_name": "PRO1", "organism": "Yeast", "refseq_name": "glutamate 5-kinase", "refseq_ac": "NP_010586", "gene_names_uniprotkb": "PRO1; D9740.12", "gene_names_refseq": "PRO1", "protein_names_uniprotkb": "Glutamate 5-kinase; 2.7.2.11; GK; Gamma-glutamyl kinase", "protein_names_refseq": "glutamate 5-kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR300C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1350780;14562106;24374639;33491328;9169867", "class_list": "", "function": "Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS9", "ec_number_list": "2.7.2.11", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004349 glutamate 5-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0055129 L-proline biosynthetic process;GO:0034517 ribophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32324-1", "uniprot_id": "EF2_YEAST", "mass": 93289.0, "length": 842, "protein_name": "Elongation factor 2", "gene_name": "EFT1; EFT2", "organism": "Yeast", "refseq_name": "elongation factor 2", "refseq_ac": "NP_010673", "gene_names_uniprotkb": "EFT1; EFT2; O3317; YOR3317W", "gene_names_refseq": "EFT2", "protein_names_uniprotkb": "Elongation factor 2; 3.6.5.-; EF-2; Eukaryotic elongation factor 2; Ribosomal translocase; Translation elongation factor 2; eEF2", "protein_names_refseq": "elongation factor 2", "tax_id": 559292, "disease": "spinocerebellar ataxia 26 (Disease Ontology:DOID:0050975); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); glaucoma (Disease Ontology:DOID:1686); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); brain glioblastoma multiforme (Disease Ontology:DOID:3073); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YDR385W); (sce:YOR133W); (R-SCE-156902); (R-SCE-5358493); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 6, "publication_count": 40, "publication_id_list": "12410829;12692531;14562095;14562106;14976550;15316019;15583292;16950777;17082187;1730643;17892487;18407956;18627462;1936278;19779198;19795423;19823750;21126336;22106047;22522802;22814378;23001565;23749301;24374639;24517342;25086354;27115996;29069440;32597660;33481703;33491328;721806;7895733;8466491;8473309;8904341;9169867;9169874;9200815;9452424", "class_list": "", "function": "Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:14976550, PubMed:16950777, PubMed:17082187, PubMed:29069440). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:14976550, PubMed:16950777, PubMed:17082187). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:14976550, PubMed:16950777, PubMed:17082187)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 43, "reported_mutagensis": 26, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT19;Q6JEF7", "ec_number_list": "2.7.1.40;5.4.2.11;3.6.5.2;3.6.5.3;2.7.1.1;4.2.1.24;3.6.5.-;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;3.6.5.4;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.5;2.1.1.314;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;3.1.1.97;1.1.1.205;2.7.1.35;2.5.1.108;3.4.19.12;2.1.1.-;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;6.3.1.14", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1990145 maintenance of translational fidelity;GO:0045901 positive regulation of translational elongation;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P32324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32325-1", "uniprot_id": "DBF4_YEAST", "mass": 80690.0, "length": 704, "protein_name": "DDK kinase regulatory subunit DBF4", "gene_name": "DBF4", "organism": "Yeast", "refseq_name": "protein serine/threonine kinase activating protein DBF4", "refseq_ac": "NP_010337", "gene_names_uniprotkb": "DBF4; D4205; DNA52; YD9609.07C", "gene_names_refseq": "DBF4; DNA52; LSD7", "protein_names_uniprotkb": "DDK kinase regulatory subunit DBF4; Dumbbell forming protein 4", "protein_names_refseq": "protein serine/threonine kinase activating protein DBF4", "tax_id": 559292, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590)", "pathway": " (sce:YDR052C); (R-SCE-176187); (R-SCE-68962)", "pathway_count": 3, "publication_count": 34, "publication_id_list": "10330168;10373538;12441400;1514326;1592236;16319063;17018296;17287358;18245450;18407956;19013276;19478884;19692334;19779198;20054399;20170732;20190278;20436286;20835227;20865002;21036905;21098477;21126336;23749301;24374639;25287299;32597660;33481703;33491328;8066465;8474449;8789263;8943332;9169867", "class_list": "", "function": "Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK also has postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 58, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS39;P32355", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0008270 zinc ion binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P32325-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32380-1", "uniprot_id": "SP110_YEAST", "mass": 111782.0, "length": 944, "protein_name": "Spindle pole body component 110", "gene_name": "SPC110", "organism": "Yeast", "refseq_name": "Spc110p", "refseq_ac": "NP_010643", "gene_names_uniprotkb": "SPC110; D9476.3; NUF1; XCM1", "gene_names_refseq": "NUF1; SPC110; XCM1", "protein_names_uniprotkb": "Spindle pole body component 110; Extragenic suppressor of CMD1-1 mutant protein 1; Nuclear filament-related protein 1; Spindle pole body spacer protein SPC110", "protein_names_refseq": "Spc110p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR356W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10339566;11278681;14562106;1541631;15872084;17213332;17330950;17563356;18407956;19520826;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23468650;23749301;24374639;24842996;32597660;33481703;33491328;36259662;7503995;8247006;9169867;9384578", "class_list": "", "function": "Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSY5", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005822 inner plaque of spindle pole body;GO:0005823 central plaque of spindle pole body", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0090063 positive regulation of microtubule nucleation;GO:0065003 protein-containing complex assembly;GO:0000022 mitotic spindle elongation;GO:1902440 protein localization to mitotic spindle pole body", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P32380-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32447-1", "uniprot_id": "ASF1_YEAST", "mass": 31603.0, "length": 279, "protein_name": "Histone chaperone ASF1", "gene_name": "ASF1", "organism": "Yeast", "refseq_name": "nucleosome assembly factor ASF1", "refseq_ac": "NP_012420", "gene_names_uniprotkb": "ASF1; CIA1; J0755", "gene_names_refseq": "ASF1; CIA1", "protein_names_uniprotkb": "Histone chaperone ASF1; Anti-silencing function protein 1; yASF1", "protein_names_refseq": "nucleosome assembly factor ASF1", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YJL115W); (R-SCE-2559584)", "pathway_count": 2, "publication_count": 75, "publication_id_list": "10591219;11172707;11331602;11404324;11412995;11731479;11731480;11756556;11856374;12093919;12626510;12851493;12917350;14562095;14562106;14585955;14680630;15071494;15175160;15452122;15542829;15542840;15632066;15766286;15821127;15840725;15891116;15901673;15972895;16020781;16039596;16141196;16143623;16303565;16407267;16428312;16501045;16582440;16627621;16678113;16815704;16936140;17046836;17081973;17107956;17320445;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;21256037;22218487;22323608;23184661;23749301;24374639;24909858;27036862;29300933;30516470;31194870;31387991;32597660;33481703;33491328;8641269;8948101;9290207", "class_list": "", "function": "Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11172707, PubMed:11331602, PubMed:11404324, PubMed:11856374, PubMed:14680630, PubMed:15071494, PubMed:15175160, PubMed:15452122, PubMed:15542829, PubMed:15766286, PubMed:15891116, PubMed:16039596, PubMed:16303565, PubMed:16407267, PubMed:16678113, PubMed:16936140). Facilitates histone deposition through both replication-dependent and replication-independent chromatin assembly pathways (PubMed:14585955, PubMed:15632066, PubMed:16678113). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with the HIR complex to promote replication-independent chromatin assembly, which may occur during transcription and DNA repair (PubMed:10591219, PubMed:11404324, PubMed:11412995, PubMed:11731479, PubMed:11731480, PubMed:11756556, PubMed:12093919, PubMed:15542840, PubMed:15821127, PubMed:16020781, PubMed:16141196, PubMed:16143623, PubMed:16303565, PubMed:16501045, PubMed:16582440). May be required for the maintenance of a subset of replication elongation factors, including DNA polymerase epsilon, the RFC complex and PCNA, at stalled replication forks (PubMed:11412995, PubMed:15901673). Also required for RTT109-dependent acetylation of histone H3 on 'Lys-9' and 'Lys-56' (PubMed:15840725, PubMed:16627621, PubMed:16815704, PubMed:17046836, PubMed:17107956, PubMed:17320445, PubMed:21256037). Promotion of RTT109-mediated histone H3 'Lys-56' acetylation is dependent on interactions with histone H3 pre-acetylated on 'Lys-14' (PubMed:31194870)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW69", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000781 chromosome, telomeric region;GO:0070775 H3 histone acetyltransferase complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 7.6, "record_id": "P32447-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32471-1", "uniprot_id": "EF1B_YEAST", "mass": 22627.0, "length": 206, "protein_name": "Elongation factor 1-beta", "gene_name": "EFB1", "organism": "Yeast", "refseq_name": "translation elongation factor 1 subunit beta", "refseq_ac": "NP_009398", "gene_names_uniprotkb": "EFB1; TEF5", "gene_names_refseq": "EFB1; TEF5", "protein_names_uniprotkb": "Elongation factor 1-beta; EF-1-beta; Eukaryotic elongation factor 1Balpha; Translation elongation factor 1B alpha; eEF1Balpha", "protein_names_refseq": "translation elongation factor 1 subunit beta", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL003W); (R-SCE-156842)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "10409717;10523624;11106763;11373622;12755685;15665377;17287358;17330950;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22106047;22218487;23749301;24374639;30516470;32597660;33481703;33491328;7731988;7895733;7941740;8420802;8935650;9298649", "class_list": "", "function": "Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A. The 30-fold higher concentration of GTP compared to GDP in cells favors the formation of eEF1A-GTP, which rapidly forms a ternary complex with aminoacyl-tRNA that in turn displaces eEF1B from the complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL3", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005840 ribosome;GO:0005853 eukaryotic translation elongation factor 1 complex", "go_biological_process": "GO:0006449 regulation of translational termination;GO:1990145 maintenance of translational fidelity;GO:0032232 negative regulation of actin filament bundle assembly;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P32471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32481-1", "uniprot_id": "IF2G_YEAST", "mass": 57866.0, "length": 527, "protein_name": "Eukaryotic translation initiation factor 2 subunit gamma", "gene_name": "GCD11", "organism": "Yeast", "refseq_name": "translation initiation factor eIF2 subunit gamma", "refseq_ac": "NP_010942", "gene_names_uniprotkb": "GCD11; SUI4; TIF213", "gene_names_refseq": "GCD11; SUI4", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit gamma; 3.6.5.3; eIF2-gamma", "protein_names_refseq": "translation initiation factor eIF2 subunit gamma", "tax_id": 559292, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (sce:YER025W); (R-SCE-156827); (R-SCE-382556); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702); (R-SCE-72731); (R-SCE-9840373)", "pathway_count": 8, "publication_count": 34, "publication_id_list": "11018020;11042214;14562106;14698289;16246727;16522633;17287358;18407956;19779198;19795423;19823750;21126336;23775072;24374639;25417110;26211610;26212456;30377154;30475211;30517694;30878599;31086188;31201334;32799315;33481703;33491328;35031321;37507029;3888989;3888990;8417348;8947054;9169868;9308967", "class_list": "", "function": "As a subunit of eukaryotic initiation factor 2 eIF2, involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS4", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.4.13;2.7.11.1;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding;GO:1990856 methionyl-initiator methionine tRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005840 ribosome;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001731 formation of translation preinitiation complex;GO:0045903 positive regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P32481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32485-1", "uniprot_id": "HOG1_YEAST", "mass": 48858.0, "length": 435, "protein_name": "Mitogen-activated protein kinase HOG1", "gene_name": "HOG1", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase HOG1", "refseq_ac": "NP_013214", "gene_names_uniprotkb": "HOG1; L2931; L9354.2; SSK3", "gene_names_refseq": "HOG1; SSK3", "protein_names_uniprotkb": "Mitogen-activated protein kinase HOG1; 2.7.11.24; High osmolarity glycerol response protein 1; MAP kinase HOG1", "protein_names_refseq": "mitogen-activated protein kinase HOG1", "tax_id": 559292, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); rectal benign neoplasm (Disease Ontology:DOID:1984); rectum cancer (Disease Ontology:DOID:1993); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastric adenocarcinoma (Disease Ontology:DOID:3717); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (sce:YLR113W); (R-SCE-168638); (R-SCE-198753); (R-SCE-418592); (R-SCE-432142); (R-SCE-450341); (R-SCE-525793); (R-SCE-6798695); (R-SCE-69601)", "pathway_count": 9, "publication_count": 71, "publication_id_list": "10198063;10805732;10817757;10970855;11113180;11136466;11230135;11309396;11336700;11796711;11875433;11922108;12086627;12455951;12477803;12482976;12637550;12743037;14562095;14562106;14680476;14685261;14737171;15060153;15177185;15448699;15707964;15773992;16260593;16321140;16371351;16467474;16688223;16790423;16857590;16885417;16896207;16920868;17220467;17346711;17363249;17429070;18407956;19684113;19779198;20489023;21126336;21177495;22218487;22814378;22984552;23749301;24374639;25492886;25523922;31772124;32597660;32973189;33481703;33491328;38270553;7523111;7681220;8662716;8943326;9032256;9090053;9169871;9211927;9744864;9817752", "class_list": "", "function": "Proline-directed serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment (PubMed:10198063, PubMed:10970855, PubMed:11230135, PubMed:11796711, PubMed:12743037, PubMed:14680476, PubMed:16321140, PubMed:16896207, PubMed:17220467, PubMed:17346711, PubMed:17363249, PubMed:38270553, PubMed:7523111, PubMed:8662716, PubMed:8943326). Controls osmotic regulation of transcription via the stress response element (STRE) in promoters of target genes (PubMed:11336700, PubMed:7523111). Upon osmotic shock, associates with the SKO1-SSN6-TUP1 complex, phosphorylates SKO1, and converts it into an activator that subsequently recruits Swi/Snf and SAGA complexes (PubMed:11230135, PubMed:12086627, PubMed:17429070). Activates the SMP1 transcription factor and the RCK2 kinase, both also involved in the regulation of the expression of a subset of osmotic stress-related genes (PubMed:10805732, PubMed:12482976). Phosphorylation of HSL1 by HOG1 leads to a G2 arrest essential for cell survival at high osmolarity (PubMed:16688223). Also mediates cell-cycle arrest in G1 phase by the dual targeting of SIC1 (PubMed:15448699). Phosphorylates methyltransferase DOT1 at least on 'Ser-565' and 'Thr-576' (PubMed:38270553). Regulates MFA2 ARE-mediated translation in response to carbon source (PubMed:16260593). Targets RPD3 histone deacetylase to osmoresponsive promoters to induce gene expression on stress (PubMed:14737171). Required for the Golgi apparatus localization of MNN1 (PubMed:9817752). Plays an essential role in maintaining water homeostasis, arsenite detoxification, copper-resistance, cold-resistance, hydrogen peroxide response, adaptation to citric acid stress, and repression of the mating pathway activity (PubMed:11136466, PubMed:11922108, PubMed:15060153, PubMed:15177185, PubMed:15773992, PubMed:16371351, PubMed:16790423, PubMed:16857590, PubMed:16885417, PubMed:16920868, PubMed:9744864). Functions as an arsenic sensor and effector via direct binding to arsenic and subsequent phosphorylation of the ARR1 transcription factor (PubMed:31772124)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYB1;Q06232;Q12294", "ec_number_list": "2.7.11.22;2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;2.7.11.11;2.7.11.1;3.6.4.13;2.4.1.1;2.7.12.2;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;2.7.12.1;2.7.11.24;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.48;2.7.11.13;3.4.25.1;3.6.4.6;3.6.5.-;3.1.26.-;2.7.11.21;2.7.1.67;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;3.1.1.5;2.7.1.35;3.4.19.12;2.4.2.7;3.6.-.-;3.1.1.-;5.4.2.7;2.3.2.26;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;3.6.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0007231 osmosensory signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 7.2, "record_id": "P32485-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32487-1", "uniprot_id": "LYP1_YEAST", "mass": 68090.0, "length": 611, "protein_name": "Lysine-specific permease", "gene_name": "LYP1", "organism": "Yeast", "refseq_name": "lysine permease", "refseq_ac": "NP_014131", "gene_names_uniprotkb": "LYP1; N0790", "gene_names_refseq": "LYP1", "protein_names_uniprotkb": "Lysine-specific permease", "protein_names_refseq": "lysine permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL268W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10654085;14562106;15665377;16847258;18407956;19684113;19779198;20702584;21177495;22106047;23749301;24374639;32597660;33481703;33491328;8368011;8740425;9169873", "class_list": "", "function": "High-affinity permease for lysine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0S6", "ec_number_list": "", "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032126 eisosome", "go_biological_process": "GO:0015802 basic amino acid transport;GO:0003333 amino acid transmembrane transport;GO:0089718 amino acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32487-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32497-1", "uniprot_id": "EIF3C_YEAST", "mass": 93204.0, "length": 812, "protein_name": "Eukaryotic translation initiation factor 3 subunit C", "gene_name": "NIP1", "organism": "Yeast", "refseq_name": "translation initiation factor eIF3 core subunit c", "refseq_ac": "NP_014040", "gene_names_uniprotkb": "NIP1; YM9924.01C; YM9952.11C", "gene_names_refseq": "NIP1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit C; Eukaryotic translation initiation factor 3 93 kDa subunit; Nuclear transport protein NIP1; Translation initiation factor eIF3, p93 subunit; eIF3 p93; eIF3c", "protein_names_refseq": "translation initiation factor eIF3 core subunit c", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR309C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 5, "publication_count": 27, "publication_id_list": "10075937;11875433;12651896;1332047;14562106;16581774;17287358;17330950;17563356;18407956;18599441;19684113;19779198;20702584;21177495;21280672;23749301;24374639;32027465;32597660;33481703;33491328;34965436;7798228;9169872;9671501;9722586", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D6", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P32497-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32501-1", "uniprot_id": "EI2BE_YEAST", "mass": 81161.0, "length": 712, "protein_name": "Translation initiation factor eIF2B subunit epsilon", "gene_name": "GCD6", "organism": "Yeast", "refseq_name": "translation initiation factor eIF2B catalytic subunit epsilon", "refseq_ac": "NP_010497", "gene_names_uniprotkb": "GCD6; TIF225; YD8142.12; YD8142B.03", "gene_names_refseq": "GCD6", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit epsilon; GCD complex subunit GCD6; Guanine nucleotide exchange factor subunit GCD6; eIF2B GDP-GTP exchange factor subunit epsilon", "protein_names_refseq": "translation initiation factor eIF2B catalytic subunit epsilon", "tax_id": 559292, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 5 (Disease Ontology:DOID:0070367)", "pathway": " (sce:YDR211W); (R-SCE-72731)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10075937;10805739;14562106;14681227;14690591;15665377;17330950;18407956;19684113;19779198;19795423;19823750;20489023;23749301;24374639;32027465;32597660;33481703;33491328;34965436;35031321;8441423;8506384;9169867;9472020", "class_list": "", "function": "Acts as a catalytic component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) and is regulated by phosphorylated eIF2. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSJ5", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P32501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32502-1", "uniprot_id": "EI2BB_YEAST", "mass": 42570.0, "length": 381, "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "GCD7", "organism": "Yeast", "refseq_name": "translation initiation factor eIF2B subunit beta", "refseq_ac": "NP_013394", "gene_names_uniprotkb": "GCD7; L8003.17; TIF222", "gene_names_refseq": "GCD7", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit beta; GCD complex subunit GCD7; Guanine nucleotide exchange factor subunit GCD7; eIF2B GDP-GTP exchange factor subunit beta", "protein_names_refseq": "translation initiation factor eIF2B subunit beta", "tax_id": 559292, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 2 (Disease Ontology:DOID:0070373)", "pathway": " (sce:YLR291C); (R-SCE-72731)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;24374639;33491328;35031321;8441423;8506384;9169871;9472020", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (By similarity). It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYT7", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32502-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32562-1", "uniprot_id": "CDC5_YEAST", "mass": 81031.0, "length": 705, "protein_name": "Cell cycle serine/threonine-protein kinase CDC5/MSD2", "gene_name": "CDC5", "organism": "Yeast", "refseq_name": "polo kinase CDC5", "refseq_ac": "NP_013714", "gene_names_uniprotkb": "CDC5; MSD2; PKX2; YM8270.03C", "gene_names_refseq": "CDC5; MSD2; PKX2", "protein_names_uniprotkb": "Cell cycle serine/threonine-protein kinase CDC5/MSD2; 2.7.11.21", "protein_names_refseq": "polo kinase CDC5", "tax_id": 559292, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); urinary bladder cancer (Disease Ontology:DOID:11054); ovary epithelial cancer (Disease Ontology:DOID:2152); endometriosis (Disease Ontology:DOID:289); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (sce:YMR001C); (R-SCE-156711); (R-SCE-162658); (R-SCE-2500257); (R-SCE-2565942); (R-SCE-6804115); (R-SCE-69601)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "11371343;11832211;12056824;14562106;14636562;16303563;17287358;18407956;19779198;19795423;19823750;20489023;22031224;22204387;23749301;24374639;32099015;32553169;32597660;33481703;33491328;8321244;9169872", "class_list": "", "function": "Protein kinase required for the cell cycle where it is involved in mitotic exit (PubMed:11371343, PubMed:32099015). A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase (PubMed:11832211, PubMed:32099015). Phosphorylates SCC1/MCD1 and NET1 (PubMed:12056824)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZH5", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.48;2.7.11.13;3.1.26.-;2.7.11.21;3.1.3.16;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0051219 phosphoprotein binding;GO:0019237 centromeric DNA binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000776 kinetochore;GO:0005816 spindle pole body", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:1904750 negative regulation of protein localization to nucleolus;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P32562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32578-1", "uniprot_id": "SIP1_YEAST", "mass": 91071.0, "length": 815, "protein_name": "SNF1 protein kinase subunit beta-1", "gene_name": "SIP1", "organism": "Yeast", "refseq_name": "Sip1p", "refseq_ac": "NP_010710", "gene_names_uniprotkb": "SIP1; D9461.11", "gene_names_refseq": "SIP1", "protein_names_uniprotkb": "SNF1 protein kinase subunit beta-1; SNF1-interacting protein 1", "protein_names_refseq": "Sip1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR422C); (R-SCE-1632852); (R-SCE-163680); (R-SCE-200425); (R-SCE-380972)", "pathway_count": 5, "publication_count": 29, "publication_id_list": "10990457;11331606;12393914;14562095;14562106;1496382;14966266;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33481703;33491328;7785324;7813428;8088514;9121458;9169867", "class_list": "", "function": "Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Promotes the PKA-regulated relocalization of the SNF1 kinase complex to the vacuolar membrane in response to various types of carbon stress., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 73, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT52", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0043254 regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P32578-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32589-1", "uniprot_id": "HSP7F_YEAST", "mass": 77366.0, "length": 693, "protein_name": "Heat shock protein homolog SSE1", "gene_name": "SSE1", "organism": "Yeast", "refseq_name": "adenyl-nucleotide exchange factor SSE1", "refseq_ac": "NP_015219", "gene_names_uniprotkb": "SSE1; LPG3C; MSI3", "gene_names_refseq": "LPG3; MSI3; SSE1", "protein_names_uniprotkb": "Heat shock protein homolog SSE1; Chaperone protein MSI3", "protein_names_refseq": "adenyl-nucleotide exchange factor SSE1", "tax_id": 559292, "disease": "Chagas disease (Disease Ontology:DOID:12140); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YPL106C); (R-SCE-3371453)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "11875433;14562095;14562106;15665377;17287358;18407956;19779198;19795423;19823750;20702584;21126336;22106047;23749301;24374639;32597660;33481703;33491328;7895733;8406043;8413180;8935650;9169875;9298649", "class_list": "", "function": "Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3R1", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042277 peptide binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006914 autophagy;GO:0006457 protein folding;GO:0042026 protein refolding;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P32589-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32597-1", "uniprot_id": "STH1_YEAST", "mass": 156743.0, "length": 1359, "protein_name": "Nuclear protein STH1/NPS1", "gene_name": "STH1", "organism": "Yeast", "refseq_name": "RSC chromatin remodeling complex ATPase subunit STH1", "refseq_ac": "NP_012140", "gene_names_uniprotkb": "STH1; NPS1", "gene_names_refseq": "NPS1; STH1", "protein_names_uniprotkb": "Nuclear protein STH1/NPS1; 3.6.4.12; ATP-dependent helicase STH1; Chromatin structure-remodeling complex protein STH1; SNF2 homolog", "protein_names_refseq": "RSC chromatin remodeling complex ATPase subunit STH1", "tax_id": 559292, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); rhabdoid tumor predisposition syndrome 2 (Disease Ontology:DOID:0060997); Coffin-Siris syndrome 4 (Disease Ontology:DOID:0070046); Nicolaides-Baraitser syndrome (Disease Ontology:DOID:0081441); blepharophimosis-impaired intellectual development syndrome (Disease Ontology:DOID:0081442); prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YIL126W)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10025404;10320476;10329629;10619019;12072455;12183366;12697820;1396591;14562106;1549132;15506919;15665377;16204215;16273108;17330950;18407956;19779198;19795423;19823750;20190278;20702584;21126336;23749301;24374639;32597660;33481703;33491328;33502312;8980231;9121424;9154831;9169870;9799253", "class_list": "", "function": "Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVG1;Q45U09", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007059 chromosome segregation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006284 base-excision repair;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P32597-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32628-1", "uniprot_id": "RAD23_YEAST", "mass": 42367.0, "length": 398, "protein_name": "UV excision repair protein RAD23", "gene_name": "RAD23", "organism": "Yeast", "refseq_name": "Rad23p", "refseq_ac": "NP_010877", "gene_names_uniprotkb": "RAD23; SYGP-ORF29", "gene_names_refseq": "RAD23", "protein_names_uniprotkb": "UV excision repair protein RAD23", "protein_names_refseq": "Rad23p", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL037C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562095;14562106;15351714;15964983;17322287;17330950;18407956;19779198;20190278;20702584;21126336;21177495;22106047;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8246991;8411151;9169868", "class_list": "", "function": "Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLL2", "ec_number_list": "", "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000111 nucleotide-excision repair factor 2 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0006517 protein deglycosylation;GO:0000715 nucleotide-excision repair, DNA damage recognition", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P32628-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32644-1", "uniprot_id": "ECM32_YEAST", "mass": 126970.0, "length": 1121, "protein_name": "Putative ATP-dependent RNA helicase ECM32", "gene_name": "ECM32", "organism": "Yeast", "refseq_name": "RNA helicase", "refseq_ac": "NP_011103", "gene_names_uniprotkb": "ECM32; HEL1; MTT1; SYGP-ORF61", "gene_names_refseq": "ECM32; HEL1; MTT1", "protein_names_uniprotkb": "Putative ATP-dependent RNA helicase ECM32; 3.6.4.13; DNA helicase B; DNA helicase III; Extracellular mutant protein 32; Hcs B; Helicase 1; Modulator of translation termination protein 1; scHelI", "protein_names_refseq": "RNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER176W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10836794;14562095;14562106;17330950;17563356;18407956;19779198;21126336;21177495;23749301;24374639;32597660;33481703;33491328;7832796;9169868;9335584;9990119", "class_list": "", "function": "Probable RNA helicase, which may be involved in modulation of the translation termination process. Probably unwinds double-stranded RNA. In vitro, unwinds covalently closed, circular DNA in the presence of a DNA topoisomerase TOP1 and replication factor-A protein RFA1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM85", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32644-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32829-1", "uniprot_id": "MRE11_YEAST", "mass": 77650.0, "length": 692, "protein_name": "Double-strand break repair protein MRE11", "gene_name": "MRE11", "organism": "Yeast", "refseq_name": "MRX complex nuclease subunit", "refseq_ac": "NP_013951", "gene_names_uniprotkb": "MRE11; YM9959.06C", "gene_names_refseq": "MRE11; NGS1; RAD58; XRS4", "protein_names_uniprotkb": "Double-strand break repair protein MRE11; 3.1.-.-", "protein_names_refseq": "MRX complex nuclease subunit", "tax_id": 559292, "disease": "ataxia-telangiectasia-like disorder 1 (Disease Ontology:DOID:0081384); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); malignant astrocytoma (Disease Ontology:DOID:3069); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); Lynch syndrome (Disease Ontology:DOID:3883); skin cancer (Disease Ontology:DOID:4159); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (sce:YMR224C); (R-SCE-1834949); (R-SCE-2559586); (R-SCE-5693548); (R-SCE-5693565)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "14522986;14562106;17330950;17563356;18407956;19779198;20702584;21177495;22002605;22031224;22705791;23080121;23749301;24374639;30516470;31537797;32597660;33481703;33491328;35501303;7625279;7789757;9169872;9651580;9845372", "class_list": "", "function": "Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:14522986, PubMed:22002605, PubMed:22705791, PubMed:23080121, PubMed:7625279, PubMed:9651580). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:22002605, PubMed:22705791, PubMed:23080121). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:22002605, PubMed:23080121). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:14522986, PubMed:22002605). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:23080121). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination (PubMed:22002605). The MRN complex is also required for the processing of R-loops (PubMed:31537797)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W049;P87289;Q07173", "ec_number_list": "3.6.-.-;5.6.2.2;3.1.-.-;2.7.11.1;2.3.1.48", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0060090 molecular adaptor activity;GO:0030145 manganese ion binding;GO:0042162 telomeric DNA binding;GO:0003691 double-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006284 base-excision repair;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P32829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32832-1", "uniprot_id": "RSC7_YEAST", "mass": 49651.0, "length": 435, "protein_name": "Chromatin structure-remodeling complex subunit RSC7", "gene_name": "NPL6", "organism": "Yeast", "refseq_name": "Npl6p", "refseq_ac": "NP_013809", "gene_names_uniprotkb": "NPL6; RSC7; YM9582.16C", "gene_names_refseq": "NPL6; RSC7", "protein_names_uniprotkb": "Chromatin structure-remodeling complex subunit RSC7; Nuclear protein localization protein 6; Remodel the structure of chromatin complex subunit 7", "protein_names_refseq": "Npl6p", "tax_id": 559292, "disease": "spina bifida (Disease Ontology:DOID:0080016); renal Wilms' tumor (Disease Ontology:DOID:5176)", "pathway": " (sce:YMR091C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562095;14562106;16204215;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21177495;22218487;22814378;24374639;30516470;32597660;33481703;33491328;9169872", "class_list": "", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Together with HTL1, LDB7, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. Acidic protein important for nuclear protein localization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZR4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006368 transcription elongation by RNA polymerase II;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P32832-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32915-1", "uniprot_id": "SC61A_YEAST", "mass": 52937.0, "length": 480, "protein_name": "Protein transport protein SEC61", "gene_name": "SEC61", "organism": "Yeast", "refseq_name": "translocon subunit SEC61", "refseq_ac": "NP_013482", "gene_names_uniprotkb": "SEC61; L3502.5", "gene_names_refseq": "SEC61", "protein_names_uniprotkb": "Protein transport protein SEC61; Sec61 complex subunit SEC61; Sec61 complex subunit alpha", "protein_names_refseq": "translocon subunit SEC61", "tax_id": 559292, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); autosomal dominant tubulointerstitial kidney disease 5 (Disease Ontology:DOID:0061120); common variable immunodeficiency (Disease Ontology:DOID:12177)", "pathway": " (sce:YLR378C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10611978;10775273;14562106;14617809;1550957;15631991;15831493;16847258;24374639;33491328;8810333;8929540;9160745;9169871", "class_list": "", "function": "Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. In an initial step, the signal sequence seems to bind simultaneously to SEC61 and SEC62. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC61 mediates the association with the ribosome., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ14", "ec_number_list": "", "go_molecular_function": "GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0015450 protein-transporting ATPase activity;GO:0008320 protein transmembrane transporter activity;GO:1904680 peptide transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005784 Sec61 translocon complex;GO:0030867 rough endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0030970 retrograde protein transport, ER to cytosol;GO:0070843 misfolded protein transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32917-1", "uniprot_id": "STE5_YEAST", "mass": 102727.0, "length": 917, "protein_name": "Protein STE5", "gene_name": "STE5", "organism": "Yeast", "refseq_name": "Ste5p", "refseq_ac": "NP_010388", "gene_names_uniprotkb": "STE5; NUL3; YD8557.12", "gene_names_refseq": "HMD3; NUL3; STE5", "protein_names_uniprotkb": "Protein STE5", "protein_names_refseq": "Ste5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR103W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;16424299;17289571;17330950;18407956;19684113;19779198;19795423;19823750;20400943;23749301;24374639;31315942;32597660;32597919;33481703;33491328;8246877;8455598;8516289;9169867", "class_list": "", "function": "Component of the pheromone signal transduction pathway. It mediates pheromone signals acting between STE20 and STE11. It is absolutely required for pheromone-induced transcription of FUS1. May play a role in cell-cycle arrest in response to pheromone., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 95, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS89", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019900 kinase binding;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043332 mating projection tip;GO:0070867 mating projection tip membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0043409 negative regulation of MAPK cascade;GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion;GO:0001403 invasive growth in response to glucose limitation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32917-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32943-1", "uniprot_id": "CGS6_YEAST", "mass": 44145.0, "length": 380, "protein_name": "S-phase entry cyclin-6", "gene_name": "CLB6", "organism": "Yeast", "refseq_name": "B-type cyclin CLB6", "refseq_ac": "NP_011623", "gene_names_uniprotkb": "CLB6; G5970", "gene_names_refseq": "CLB6", "protein_names_uniprotkb": "S-phase entry cyclin-6", "protein_names_refseq": "B-type cyclin CLB6", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (sce:YGR109C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17322287;24374639;33481703;33491328;8253070;8319908;8905931;9169869", "class_list": "", "function": "Involved in G1/S and or S phase progression. Interacts with CDC28., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUP0", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription;GO:0032880 regulation of protein localization;GO:0000082 G1/S transition of mitotic cell cycle;GO:0001932 regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33203-1", "uniprot_id": "PRP40_YEAST", "mass": 69065.0, "length": 583, "protein_name": "Pre-mRNA-processing protein PRP40", "gene_name": "PRP40", "organism": "Yeast", "refseq_name": "snoRNA-splicing protein PRP40", "refseq_ac": "NP_012913", "gene_names_uniprotkb": "PRP40; YKL165", "gene_names_refseq": "PRP40", "protein_names_uniprotkb": "Pre-mRNA-processing protein PRP40", "protein_names_refseq": "snoRNA-splicing protein PRP40", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL012W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10978320;12460579;1481574;15020406;18407956;19779198;24374639;33491328;8196765;8622699;9012791;9150140", "class_list": "", "function": "Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXS4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P33203-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33313-1", "uniprot_id": "CNS1_YEAST", "mass": 44112.0, "length": 385, "protein_name": "Hsp70/Hsp90 co-chaperone CNS1", "gene_name": "CNS1", "organism": "Yeast", "refseq_name": "HSP70/90 family co-chaperone CNS1", "refseq_ac": "NP_009713", "gene_names_uniprotkb": "CNS1; YBR1205", "gene_names_refseq": "CNS1", "protein_names_uniprotkb": "Hsp70/Hsp90 co-chaperone CNS1; Cyclophilin seven suppressor 1; STI1 stress-inducible protein homolog", "protein_names_refseq": "HSP70/90 family co-chaperone CNS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR155W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12788914;14562095;14562106;15044454;17322287;22218487;24374639;30876805;33481703;33491328;7813418;8488729;9819421;9819422", "class_list": "", "function": "Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins. Client proteins include eukaryotic elongation factor eEF2, a key player in cellular translation (PubMed:12788914, PubMed:15044454, PubMed:30876805). Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity (PubMed:15044454)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQF0;Q02125", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P33313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33332-1", "uniprot_id": "SEC3_YEAST", "mass": 154695.0, "length": 1336, "protein_name": "Exocyst complex component SEC3", "gene_name": "SEC3", "organism": "Yeast", "refseq_name": "GTP-Rho binding exocyst subunit SEC3", "refseq_ac": "NP_010924", "gene_names_uniprotkb": "SEC3; PSL1", "gene_names_refseq": "PSL1; SEC3", "protein_names_uniprotkb": "Exocyst complex component SEC3; Protein PSL1", "protein_names_refseq": "GTP-Rho binding exocyst subunit SEC3", "tax_id": 559292, "disease": "", "pathway": " (sce:YER008C); (R-SCE-264876)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "11875433;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20139078;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33229814;33481703;33491328;8889515;8978675;9169868;9247645", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D3DLQ5", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000145 exocyst;GO:0000131 incipient cellular bud site;GO:0005628 prospore membrane", "go_biological_process": "GO:0051601 exocyst localization;GO:0015031 protein transport;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P33332-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33416-1", "uniprot_id": "HSP78_YEAST", "mass": 91336.0, "length": 811, "protein_name": "Heat shock protein 78, mitochondrial", "gene_name": "HSP78", "organism": "Yeast", "refseq_name": "chaperone ATPase HSP78", "refseq_ac": "NP_010544", "gene_names_uniprotkb": "HSP78; YD9320A.08C", "gene_names_refseq": "HSP78", "protein_names_uniprotkb": "Heat shock protein 78, mitochondrial", "protein_names_refseq": "chaperone ATPase HSP78", "tax_id": 559292, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); 3-methylglutaconic aciduria type 7a (Disease Ontology:DOID:0081133); 3-methylglutaconic aciduria type 7b (Disease Ontology:DOID:0081134)", "pathway": " (sce:YDR258C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11231020;11734006;12023279;12237310;14562095;14562106;14576278;16339719;16460754;16545993;18407956;21126336;24374639;33491328;7500331;7628444;8413229;8830768;9169867", "class_list": "", "function": "Required, in concert with mitochondrial Hsp70 (SSC1), for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress. Its main role may be maintaining the molecular chaperone SSC1 in a soluble and functional state. Also required for the efficient degradation of proteins by matrix protease PIM1, independent on its protein remodeling activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSN8;Q12137", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0043335 protein unfolding;GO:0034605 cellular response to heat;GO:0050821 protein stabilization;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P33416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34078-1", "uniprot_id": "LTV1_YEAST", "mass": 53390.0, "length": 463, "protein_name": "Protein LTV1", "gene_name": "LTV1", "organism": "Yeast", "refseq_name": "ribosome biogenesis protein LTV1", "refseq_ac": "NP_012779", "gene_names_uniprotkb": "LTV1; YKL2", "gene_names_refseq": "LTV1; YKL2", "protein_names_uniprotkb": "Protein LTV1; Low-temperature viability protein 1", "protein_names_refseq": "ribosome biogenesis protein LTV1", "tax_id": 559292, "disease": "inflammatory poikiloderma with hair abnormalities and acral keratoses (Disease Ontology:DOID:0070510)", "pathway": " (sce:YKL143W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "14562095;14562106;15611164;1574929;16732272;16738661;16888326;18407956;19779198;19795423;19823750;21177495;22218487;22814378;24374639;25778921;32138239;33481703;33491328;8196765", "class_list": "", "function": "Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX53", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0015031 protein transport;GO:0034599 cellular response to oxidative stress;GO:0032456 endocytic recycling;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P34078-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34164-1", "uniprot_id": "SIP2_YEAST", "mass": 46405.0, "length": 415, "protein_name": "SNF1 protein kinase subunit beta-2", "gene_name": "SIP2", "organism": "Yeast", "refseq_name": "Sip2p", "refseq_ac": "NP_011307", "gene_names_uniprotkb": "SIP2; G1155; SPM2", "gene_names_refseq": "SIP2; SPM2", "protein_names_uniprotkb": "SNF1 protein kinase subunit beta-2; Protein SPM2; SNF1-interacting protein 2", "protein_names_refseq": "Sip2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL208W); (R-SCE-1632852); (R-SCE-163680); (R-SCE-200425); (R-SCE-380972)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "10990457;11331606;12393914;12562756;14562106;17287358;17563356;17851534;18407956;19779198;19795423;19823750;20489023;21177495;22019086;23749301;24374639;32597660;33481703;33491328;7813428;8813766;9121458;9153757;9169869", "class_list": "", "function": "Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Involved in the regulation of aging. Acts as a negative regulator of nuclear SNF1 activity in young cells by sequestering its activating gamma subunit at the plasma membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTU7", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0007165 signal transduction;GO:0042149 cellular response to glucose starvation;GO:0043254 regulation of protein-containing complex assembly;GO:0001403 invasive growth in response to glucose limitation;GO:0030447 filamentous growth", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P34164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34230-1", "uniprot_id": "PXA2_YEAST", "mass": 97126.0, "length": 853, "protein_name": "Peroxisomal long-chain fatty acid import protein 1", "gene_name": "PXA2", "organism": "Yeast", "refseq_name": "ATP-binding cassette long-chain fatty acid transporter PXA2", "refseq_ac": "NP_012733", "gene_names_uniprotkb": "PXA2; PAT1; YKL741", "gene_names_refseq": "PAT1; PXA2", "protein_names_uniprotkb": "Peroxisomal long-chain fatty acid import protein 1; Peroxisomal ABC transporter 2", "protein_names_refseq": "ATP-binding cassette long-chain fatty acid transporter PXA2", "tax_id": 559292, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (sce:YKL188C); (R-SCE-1369062); (R-SCE-2046105); (R-SCE-2046106); (R-SCE-390247); (R-SCE-9603798)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "18757502;24374639;33491328;35127709;7941751;8154185;8196765;8670886;8876235", "class_list": "", "function": "Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix (PubMed:18757502, PubMed:8670886). Also plays a role in the peroxisomal uptake of ATP (PubMed:35127709)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "D6VX12", "ec_number_list": "", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process;GO:0007031 peroxisome organization;GO:0015910 long-chain fatty acid import into peroxisome;GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P34230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34241-1", "uniprot_id": "URB1_YEAST", "mass": 203287.0, "length": 1764, "protein_name": "Nucleolar pre-ribosomal-associated protein 1", "gene_name": "URB1", "organism": "Yeast", "refseq_name": "Urb1p", "refseq_ac": "NP_012911", "gene_names_uniprotkb": "URB1; NPA1", "gene_names_refseq": "NPA1; URB1", "protein_names_uniprotkb": "Nucleolar pre-ribosomal-associated protein 1; Unhealthy ribosome biogenesis protein 1", "protein_names_refseq": "Urb1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL014C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;15208443;15226434;15242642;17145778;20489023;23749301;24374639;33491328;8154185;8196765", "class_list": "", "function": "Required for 60S ribosomal subunit formation and pre-rRNA processing. Required for normal accumulation of 25S and 5.8S rRNAs., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXS2;P34242", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P34241-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34909-1", "uniprot_id": "NOT4_YEAST", "mass": 65354.0, "length": 587, "protein_name": "General negative regulator of transcription subunit 4", "gene_name": "MOT2", "organism": "Yeast", "refseq_name": "CCR4-NOT core ubiquitin-protein ligase subunit MOT2", "refseq_ac": "NP_010991", "gene_names_uniprotkb": "MOT2; CCL1; NOT4; SIG1; SSF1", "gene_names_refseq": "MOT2; NOT4; SIG1", "protein_names_uniprotkb": "General negative regulator of transcription subunit 4; 2.3.2.27; Modulator of transcription 2", "protein_names_refseq": "CCR4-NOT core ubiquitin-protein ligase subunit MOT2", "tax_id": 559292, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": " (sce:YER068W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10490603;11733989;14562106;17330950;17563356;18407956;19684113;19779198;20386698;21177495;22106047;23749301;24374639;30516470;30609991;32597660;33229814;33481703;33491328;7926748;8039500;8164669;8164670;9169868;9463387", "class_list": "", "function": "E3 ubiquitin-protein ligase component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (PubMed:30609991, PubMed:9463387). The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes (PubMed:9463387). Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (PubMed:9463387). In the cytoplasm, catalyzes monoubiquitination of RPS7/es7 in response to stalled ribosomes, initiating a HEL2-dependent response that activates the No-Go Decay (NGD) pathway (PubMed:30609991)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D3DLX3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0010498 proteasomal protein catabolic process;GO:0000209 protein polyubiquitination;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P34909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35190-1", "uniprot_id": "CLG1_YEAST", "mass": 51571.0, "length": 452, "protein_name": "PHO85 cyclin CLG1", "gene_name": "CLG1", "organism": "Yeast", "refseq_name": "Clg1p", "refseq_ac": "NP_011300", "gene_names_uniprotkb": "CLG1; G1105", "gene_names_refseq": "CLG1", "protein_names_uniprotkb": "PHO85 cyclin CLG1; Cyclin-like G1 protein 1", "protein_names_refseq": "Clg1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL215W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "20489023;24374639;33491328;8212900;9032248;9153757;9169869;9290212", "class_list": "", "function": "Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Has a role in cell integrity and polarized cell growth together with the other PCL1/PCL2 cyclin family members., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTU1", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0016239 positive regulation of macroautophagy;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35190-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35198-1", "uniprot_id": "MTH1_YEAST", "mass": 49060.0, "length": 433, "protein_name": "Protein MTH1", "gene_name": "MTH1", "organism": "Yeast", "refseq_name": "Mth1p", "refseq_ac": "NP_010563", "gene_names_uniprotkb": "MTH1; D9954.12", "gene_names_refseq": "BPC1; DGT1; HTR1; MTH1", "protein_names_uniprotkb": "Protein MTH1", "protein_names_refseq": "Mth1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR277C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21177495;24374639;8114728;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSQ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35200-1", "uniprot_id": "UPS2_YEAST", "mass": 26506.0, "length": 230, "protein_name": "Protein UPS2, mitochondrial", "gene_name": "UPS2", "organism": "Yeast", "refseq_name": "Ups2p", "refseq_ac": "NP_013269", "gene_names_uniprotkb": "UPS2; AIM30; GEP1; L9470.15; MSF1", "gene_names_refseq": "AIM30; GEP1; MSF1'; MSF1; UPS2", "protein_names_uniprotkb": "Protein UPS2, mitochondrial; Altered inheritance rate of mitochondrion protein 30; Genetic interactor of prohibitins protein 1; Unprocessed MGM1 protein 2", "protein_names_refseq": "Ups2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR168C); (R-SCE-6803204)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562095;14562106;19221197;19300474;19506038;20622808;20657548;24374639;8373805;9169871", "class_list": "", "function": "Required for mitochondrial cristae morphogenesis and MGM1-processing. Controls the stability of mitochondrial phosphatidylethanolamine (PE). With UPS1, controls the level of cardiolipin in mitochondria. Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYH4", "ec_number_list": "", "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015914 phospholipid transport;GO:0042407 cristae formation;GO:0032048 cardiolipin metabolic process;GO:2001246 negative regulation of phosphatidylcholine biosynthetic process;GO:0046337 phosphatidylethanolamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35718-1", "uniprot_id": "RPC8_YEAST", "mass": 24326.0, "length": 212, "protein_name": "DNA-directed RNA polymerase III subunit RPC8", "gene_name": "RPC25", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase III subunit RPC25", "refseq_ac": "NP_012778", "gene_names_uniprotkb": "RPC25; UNF1; YKL1", "gene_names_refseq": "RPC25; YKL1", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC8; DNA-directed RNA polymerase III 25 kDa polypeptide; RNA polymerase III subunit C25; RNA polymerase III subunit C8", "protein_names_refseq": "DNA-directed RNA polymerase III subunit RPC25", "tax_id": 559292, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (sce:YKL144C); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10384303;12482973;14562106;1574929;16818233;17330950;18407956;19779198;24374639;33491328;8065349;8196765", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX52", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P35718-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36054-1", "uniprot_id": "RCN1_YEAST", "mass": 24135.0, "length": 211, "protein_name": "Calcipressin-like protein", "gene_name": "RCN1", "organism": "Yeast", "refseq_name": "Rcn1p", "refseq_ac": "NP_012763", "gene_names_uniprotkb": "RCN1; DSCR1L; YKL613", "gene_names_refseq": "RCN1", "protein_names_uniprotkb": "Calcipressin-like protein; Down syndrome candidate region 1-like protein; Regulator of calcineurin 1", "protein_names_refseq": "Rcn1p", "tax_id": 559292, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (sce:YKL159C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10756093;10887154;14562106;14701880;17954914;18407956;19273587;19779198;21126336;23749301;24374639;27821475;33481703;33491328;34965436;8091859;8196765", "class_list": "", "function": "Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX40", "ec_number_list": "", "go_molecular_function": "GO:0030346 protein phosphatase 2B binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P36054-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36102-1", "uniprot_id": "PAN3_YEAST", "mass": 76455.0, "length": 679, "protein_name": "PAN2-PAN3 deadenylation complex subunit PAN3", "gene_name": "PAN3", "organism": "Yeast", "refseq_name": "PAN-complex poly(A)-binding subunit PAN3", "refseq_ac": "NP_012900", "gene_names_uniprotkb": "PAN3; ECM35", "gene_names_refseq": "ECM35; PAN3", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex subunit PAN3; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 3; Poly(A)-nuclease deadenylation complex subunit 3", "protein_names_refseq": "PAN-complex poly(A)-binding subunit PAN3", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL025C); (R-SCE-429947)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "11953437;1358757;14562095;14562106;15169912;15894541;16330754;17330950;17563356;17595167;18407956;19779198;23749301;24374639;24872509;24880344;32597660;33481703;33491328;8196765;8816488;9774670", "class_list": "", "function": "Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006397 mRNA processing;GO:0006301 DNA damage tolerance;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P36102-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36122-1", "uniprot_id": "BCH2_YEAST", "mass": 88044.0, "length": 765, "protein_name": "Protein BCH2", "gene_name": "BCH2", "organism": "Yeast", "refseq_name": "Bch2p", "refseq_ac": "NP_012952", "gene_names_uniprotkb": "BCH2; FMP50", "gene_names_refseq": "BCH2; FMP50", "protein_names_uniprotkb": "Protein BCH2; BUD7 and CHS6 homolog 2", "protein_names_refseq": "Bch2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR027W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;16498409;16855022;17000877;17563356;18407956;23749301;24374639;33491328;8196765", "class_list": "", "function": "Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX92", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030140 trans-Golgi network transport vesicle;GO:0034044 exomer complex", "go_biological_process": "GO:0015031 protein transport;GO:0006893 Golgi to plasma membrane transport;GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36124-1", "uniprot_id": "SET3_YEAST", "mass": 85480.0, "length": 751, "protein_name": "Histone reader SET3", "gene_name": "SET3", "organism": "Yeast", "refseq_name": "histone-binding protein SET3", "refseq_ac": "NP_012954", "gene_names_uniprotkb": "SET3", "gene_names_refseq": "SET3", "protein_names_uniprotkb": "Histone reader SET3; SET domain-containing protein 3", "protein_names_refseq": "histone-binding protein SET3", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 23 (Disease Ontology:DOID:0070053); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (sce:YKR029C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11711434;12434058;14562106;18407956;19779198;19795423;19823750;20702584;21177495;23749301;23798402;24374639;27697561;30377154;32597660;33229814;33481703;33491328;8196765", "class_list": "", "function": "Histone reader that recognizes histone H3 di- or tri-methylated at 'Lys-4' and acts as part of large multiprotein complexes that modify and/or remodel chromatin to regulate transcription (PubMed:12434058, PubMed:23798402, PubMed:27697561). Required for both gene activation and repression (PubMed:12434058). Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis (PubMed:12434058). Required for the transcriptional activation of genes with high activity (PubMed:12434058)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VX94", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0034967 Set3 complex;GO:0070210 Rpd3L-Expanded complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006479 protein methylation;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P36124-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37366-1", "uniprot_id": "CCL1_YEAST", "mass": 45210.0, "length": 393, "protein_name": "Cyclin CCL1", "gene_name": "CCL1", "organism": "Yeast", "refseq_name": "TFIIH complex kinase subunit CCL1", "refseq_ac": "NP_015350", "gene_names_uniprotkb": "CCL1; YP9367.05C", "gene_names_refseq": "CCL1", "protein_names_uniprotkb": "Cyclin CCL1", "protein_names_refseq": "TFIIH complex kinase subunit CCL1", "tax_id": 559292, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (sce:YPR025C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 11, "publication_id_list": "11839796;14562106;20489023;21126336;23749301;24374639;33481703;33491328;8230216;9169875;9235928", "class_list": "", "function": "Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W435", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005675 transcription factor TFIIH holo complex;GO:0070985 transcription factor TFIIK complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010508 positive regulation of autophagy;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006995 cellular response to nitrogen starvation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P37366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38181-1", "uniprot_id": "NU170_YEAST", "mass": 169475.0, "length": 1502, "protein_name": "Nucleoporin NUP170", "gene_name": "NUP170", "organism": "Yeast", "refseq_name": "Nup170p", "refseq_ac": "NP_009474", "gene_names_uniprotkb": "NUP170; NLE3; YBL0725", "gene_names_refseq": "NLE3; NUP170", "protein_names_uniprotkb": "Nucleoporin NUP170; Nuclear pore protein NUP170", "protein_names_refseq": "Nup170p", "tax_id": 559292, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650)", "pathway": " (sce:YBL079W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10684247;11290711;12403813;12473689;12791264;14562106;14697200;18407956;19674973;19779198;22031224;23749301;24374639;32597660;33481703;33491328;7502586;7813418;8522578;9864357", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPS4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0044877 protein-containing complex binding;GO:0017056 structural constituent of nuclear pore;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044611 nuclear pore inner ring;GO:0099115 chromosome, subtelomeric region", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0007059 chromosome segregation;GO:0051292 nuclear pore complex assembly;GO:0031507 heterochromatin formation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38181-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38232-1", "uniprot_id": "REG2_YEAST", "mass": 38747.0, "length": 338, "protein_name": "Protein REG2", "gene_name": "REG2", "organism": "Yeast", "refseq_name": "protein phosphatase regulator REG2", "refseq_ac": "NP_009606", "gene_names_uniprotkb": "REG2; YBR0504", "gene_names_refseq": "REG2", "protein_names_uniprotkb": "Protein REG2", "protein_names_refseq": "protein phosphatase regulator REG2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR050C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17322287;24374639;7597852;7813418;8649403", "class_list": "", "function": "Regulatory subunit, binds to type-1 protein phosphatase. Functions with HEX2/REG1 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ50", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:1904547 regulation of cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P38232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38249-1", "uniprot_id": "EIF3A_YEAST", "mass": 110344.0, "length": 964, "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "RPG1", "organism": "Yeast", "refseq_name": "translation initiation factor eIF3 core subunit a", "refseq_ac": "NP_009635", "gene_names_uniprotkb": "RPG1; TIF32; YBR0734", "gene_names_refseq": "RPG1; TIF32", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit A; Eukaryotic translation initiation factor 3 110 kDa subunit homolog; Translation initiation factor eIF3, p110 subunit homolog; eIF3 p110; eIF3a", "protein_names_refseq": "translation initiation factor eIF3 core subunit a", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR079C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 5, "publication_count": 27, "publication_id_list": "10358023;11387228;12651896;14562106;15665377;16581774;17330950;17563356;18407956;18599441;18765792;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;32027465;32597660;33481703;33491328;7813418;7985423;9671501;9694884", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ78", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex", "go_biological_process": "GO:0002188 translation reinitiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P38249-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38257-1", "uniprot_id": "MMS4_YEAST", "mass": 78764.0, "length": 691, "protein_name": "Crossover junction endonuclease MMS4", "gene_name": "MMS4", "organism": "Yeast", "refseq_name": "Mms4p", "refseq_ac": "NP_009656", "gene_names_uniprotkb": "MMS4; SLX2; YBR0826; YBR0829; YBR100W", "gene_names_refseq": "MMS4; SLX2; YBR100W", "protein_names_uniprotkb": "Crossover junction endonuclease MMS4; 3.1.22.-", "protein_names_refseq": "Mms4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR098W); (R-SCE-5693568)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "11139495;11641278;11779793;12473680;12475932;12724407;12750322;14527420;14642571;14752007;15590332;15611158;17322287;18407956;19779198;19795423;19823750;22814378;23749301;24374639;28096179;32597660;33481703;33491328;7813418;7900426;9604884", "class_list": "", "function": "Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions. Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures. May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover. In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved. Spore formation and viability are severely impaired in deletion strains., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ99;P38259;Q6B1Z9;Q9URQ2", "ec_number_list": "3.1.22.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0048476 Holliday junction resolvase complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P38257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38260-1", "uniprot_id": "FES1_YEAST", "mass": 32604.0, "length": 290, "protein_name": "Hsp70 nucleotide exchange factor FES1", "gene_name": "FES1", "organism": "Yeast", "refseq_name": "Hsp70 nucleotide exchange factor FES1", "refseq_ac": "NP_009659", "gene_names_uniprotkb": "FES1; YBR0830", "gene_names_refseq": "FES1", "protein_names_uniprotkb": "Hsp70 nucleotide exchange factor FES1; Factor exchange for SSA1 protein 1", "protein_names_refseq": "Hsp70 nucleotide exchange factor FES1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR101C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12052876;12417338;14562095;14562106;15082786;15680904;15694338;15855155;16374585;16688211;16688212;17132105;17322287;18407956;19779198;23749301;24374639;33481703;33491328;7813418;7900426", "class_list": "", "function": "Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQA0", "ec_number_list": "", "go_molecular_function": "GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P38260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38307-1", "uniprot_id": "DER1_YEAST", "mass": 24391.0, "length": 211, "protein_name": "Degradation in the endoplasmic reticulum protein 1", "gene_name": "DER1", "organism": "Yeast", "refseq_name": "derlin", "refseq_ac": "NP_009760", "gene_names_uniprotkb": "DER1; YBR1413", "gene_names_refseq": "DER1", "protein_names_uniprotkb": "Degradation in the endoplasmic reticulum protein 1", "protein_names_refseq": "derlin", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR201W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10847680;14562106;15093775;16847258;16873066;20005842;23363603;24374639;32327568;7813418;7975899;8631297", "class_list": "", "function": "Component of the endoplasmic reticulum-associated degradation (ERAD) pathway. Specifically required for the ERAD-L pathway which mediates the degradation of proteins with misfolded lumenal domains within the endoplasmic reticulum (ER). Facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with HRD1 (PubMed:32327568). Both proteins have lateral gates facing each other and distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQJ8", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0030970 retrograde protein transport, ER to cytosol;GO:0070843 misfolded protein transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38348-1", "uniprot_id": "HSM3_YEAST", "mass": 55543.0, "length": 480, "protein_name": "DNA mismatch repair protein HSM3", "gene_name": "HSM3", "organism": "Yeast", "refseq_name": "Hsm3p", "refseq_ac": "NP_009831", "gene_names_uniprotkb": "HSM3; YBR1740", "gene_names_refseq": "HSM3", "protein_names_uniprotkb": "DNA mismatch repair protein HSM3; Enhanced spontaneous mutability protein 3", "protein_names_refseq": "Hsm3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR272C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10681182;10681183;14562095;14562106;15450405;17322287;19217412;19412159;19412160;19446322;19795423;19823750;24374639;33491328;7813418;9539417", "class_list": "", "function": "Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR8", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006298 mismatch repair;GO:0070682 proteasome regulatory particle assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38348-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38631-1", "uniprot_id": "FKS1_YEAST", "mass": 214851.0, "length": 1876, "protein_name": "1,3-beta-glucan synthase component FKS1", "gene_name": "FKS1", "organism": "Yeast", "refseq_name": "1,3-beta-D-glucan synthase", "refseq_ac": "NP_013446", "gene_names_uniprotkb": "FKS1; CND1; CWH53; ETG1; GLS1; GSC1; L8300.6; PBR1", "gene_names_refseq": "CND1; CWH53; ETG1; FKS1; GSC1; PBR1", "protein_names_uniprotkb": "1,3-beta-glucan synthase component FKS1; 1,3-beta-D-glucan-UDP glucosyltransferase; 2.4.1.34; Calcineurin dependent protein 1; Calcofluor white hypersensitivity protein 53; Echinocandin target gene protein 1; FK506 sensitivity protein 1; Glucan synthase of cerevisiae protein 1; Papulacandin B resistance protein 1", "protein_names_refseq": "1,3-beta-D-glucan synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR342W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11856368;12185837;12399379;14557538;14576278;14693557;15166135;17142567;18407956;19779198;22106047;23749301;24374639;32597660;33481703;33491328;40021629;7510323;7528927;7530227;7542741;7565718;7592316;7649185;7828729;8602515;8662910;9169871", "class_list": "", "function": "Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS) complex (PubMed:11856368). Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall (PubMed:11856368, PubMed:40021629). Involved in cell wall synthesis, maintenance and remodeling (PubMed:11856368, PubMed:40021629)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 28, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYY0;Q53YZ4;Q6TKS9;Q6TKT0", "ec_number_list": "2.4.1.34", "go_molecular_function": "GO:0003843 1,3-beta-D-glucan synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0030479 actin cortical patch;GO:0000148 1,3-beta-D-glucan synthase complex", "go_biological_process": "GO:0045807 positive regulation of endocytosis;GO:0008361 regulation of cell size;GO:0006075 (1->3)-beta-D-glucan biosynthetic process;GO:0009272 fungal-type cell wall biogenesis;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P38631-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38634-1", "uniprot_id": "SIC1_YEAST", "mass": 32223.0, "length": 284, "protein_name": "Protein SIC1", "gene_name": "SIC1", "organism": "Yeast", "refseq_name": "cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1", "refseq_ac": "NP_013180", "gene_names_uniprotkb": "SIC1; L9449.8; SDB25", "gene_names_refseq": "BYC1; SDB25; SIC1", "protein_names_uniprotkb": "Protein SIC1; CDK inhibitor p40", "protein_names_refseq": "cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR079W)", "pathway_count": 1, "publication_count": 43, "publication_id_list": "11734846;14562095;14562106;14756785;15448699;15665377;16168390;16776651;16777072;17302822;17330950;18407956;19008353;19684113;19779198;19795423;19823750;20399186;20489023;20702584;21126336;21177495;21993622;22218487;22638969;23230424;23749301;24130459;24374639;26356805;28496991;32296067;32597660;33210757;33229814;33481703;33491328;7958845;8164683;9169871;9334303;9346239;9725902", "class_list": "", "function": "Substrate and inhibitor of the cyclin-dependent protein kinase CDC28. Its activity could be important for faithful segregation of chromosomes to daughter cells. It acts in response to a signal from a post-start checkpoint., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 39, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VY79", "ec_number_list": "", "go_molecular_function": "GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:1905761 SCF ubiquitin ligase complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle;GO:0016242 negative regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 5.4, "record_id": "P38634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38768-1", "uniprot_id": "PIH1_YEAST", "mass": 39519.0, "length": 344, "protein_name": "Protein interacting with Hsp90 1", "gene_name": "PIH1", "organism": "Yeast", "refseq_name": "Pih1p", "refseq_ac": "NP_011899", "gene_names_uniprotkb": "PIH1; NOP17", "gene_names_refseq": "NOP17; PIH1", "protein_names_uniprotkb": "Protein interacting with Hsp90 1; Nucleolar protein 17", "protein_names_refseq": "Pih1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR034C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;15670595;15766533;16128814;24374639;33491328;8091229", "class_list": "", "function": "Involved in pre-rRNA processing and required for the NOP58-snoRNA interaction., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKY1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0050821 protein stabilization;GO:0008380 RNA splicing;GO:0006457 protein folding;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38768-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38779-1", "uniprot_id": "CIC1_YEAST", "mass": 42530.0, "length": 376, "protein_name": "Proteasome-interacting protein CIC1", "gene_name": "CIC1", "organism": "Yeast", "refseq_name": "Cic1p", "refseq_ac": "NP_011919", "gene_names_uniprotkb": "CIC1; NSA3", "gene_names_refseq": "CIC1; NSA3", "protein_names_uniprotkb": "Proteasome-interacting protein CIC1; Core interacting component 1", "protein_names_refseq": "Cic1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR052W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11500370;11583614;11875433;14562095;14562106;14623999;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21177495;23749301;24374639;24909858;32597660;33481703;33491328;8091229", "class_list": "", "function": "An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex. Required for turnover of cell cycle regulatory proteins CDC4 and GRR1. Required for synthesis and nuclear export of 60S ribosomal subunits. Required for vegetative growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL01", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0019843 rRNA binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0000502 proteasome complex", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0030163 protein catabolic process;GO:0006364 rRNA processing;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38805-1", "uniprot_id": "RPF1_YEAST", "mass": 35121.0, "length": 295, "protein_name": "Ribosome production factor 1", "gene_name": "RPF1", "organism": "Yeast", "refseq_name": "rRNA-binding ribosome biosynthesis protein RPF1", "refseq_ac": "NP_011956", "gene_names_uniprotkb": "RPF1", "gene_names_refseq": "RPF1", "protein_names_uniprotkb": "Ribosome production factor 1; Ribosome biogenesis protein RPF1", "protein_names_refseq": "rRNA-binding ribosome biosynthesis protein RPF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR088W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11864606;12702244;14562106;22814378;24374639;33481703;33491328;8091229", "class_list": "", "function": "Essential protein. Required for biogenesis of the 60S ribosomal subunit., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL40", "ec_number_list": "", "go_molecular_function": "GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0000460 maturation of 5.8S rRNA;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38825-1", "uniprot_id": "TOM71_YEAST", "mass": 71856.0, "length": 639, "protein_name": "Protein TOM71", "gene_name": "TOM71", "organism": "Yeast", "refseq_name": "protein channel TOM71", "refseq_ac": "NP_011985", "gene_names_uniprotkb": "TOM71; TOM72", "gene_names_refseq": "TOM71; TOM72", "protein_names_uniprotkb": "Protein TOM71; 71 kDa mitochondrial outer membrane protein", "protein_names_refseq": "protein channel TOM71", "tax_id": 559292, "disease": "hypothyroidism (Disease Ontology:DOID:1459); congestive heart failure (Disease Ontology:DOID:6000); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YHR117W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562095;14562106;14576278;16407407;16689936;17287358;17330950;18007655;18407956;19684113;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;8091229;8612740;8663394", "class_list": "", "function": "Involved in MBF1-mediated mitochondrial morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL67", "ec_number_list": "", "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P38825-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38827-1", "uniprot_id": "SET1_YEAST", "mass": 123912.0, "length": 1080, "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-4 specific", "gene_name": "SET1", "organism": "Yeast", "refseq_name": "histone methyltransferase SET1", "refseq_ac": "NP_011987", "gene_names_uniprotkb": "SET1; KMT2; YTX1", "gene_names_refseq": "KMT2; SET1; YTX1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase, H3 lysine-4 specific; 2.1.1.354; COMPASS component SET1; Lysine N-methyltransferase 2; SET domain-containing protein 1", "protein_names_refseq": "histone methyltransferase SET1", "tax_id": 559292, "disease": "neurodevelopmental disorder with speech impairment and dysmorphic facies (Disease Ontology:DOID:0070417); early-onset epilepsy 2 (Disease Ontology:DOID:0070471); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YHR119W); (R-SCE-9772755)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "11687631;11742990;11751634;11752412;11805083;11818070;12060701;12353038;12845608;14562106;14636589;15949446;16787775;17287358;17330950;18022353;18407956;19779198;24374639;29071121;31922488;32597660;33481703;33491328;35183557;8091229;9398665;9988274", "class_list": "", "function": "Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3 (PubMed:11742990, PubMed:11751634, PubMed:11752412, PubMed:11805083, PubMed:11818070, PubMed:12060701, PubMed:12353038, PubMed:12845608, PubMed:14636589, PubMed:15949446, PubMed:29071121). Binds RNAs involved in chromosome segregation, splicing and transcriptional regulation; appears to bind transcripts both co- and post-transcriptionally and binding might negatively affect its histone methyltransferase activity (PubMed:16787775, PubMed:29071121). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (PubMed:31922488). Plays a role in telomere length maintenance and transcription elongation regulation (PubMed:11742990, PubMed:11751634, PubMed:11805083, PubMed:11818070, PubMed:14636589, PubMed:15949446, PubMed:9398665, PubMed:9988274)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL69", "ec_number_list": "2.1.1.354", "go_molecular_function": "GO:0003723 RNA binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048188 Set1C/COMPASS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P38827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38853-1", "uniprot_id": "KEL1_YEAST", "mass": 131094.0, "length": 1164, "protein_name": "Kelch repeat-containing protein 1", "gene_name": "KEL1", "organism": "Yeast", "refseq_name": "Kel1p", "refseq_ac": "NP_012028", "gene_names_uniprotkb": "KEL1", "gene_names_refseq": "KEL1", "protein_names_uniprotkb": "Kelch repeat-containing protein 1", "protein_names_refseq": "Kel1p", "tax_id": 559292, "disease": "methylmalonic acidemia and homocysteinemia cblX type (Disease Ontology:DOID:0111814); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YHR158C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "14562106;15665377;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;34965436;8091229;9786949", "class_list": "", "function": "Has a role in cell morphogenesis and cell fusion and may antagonize the PKC1 pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 94, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D3DLA7;E9P8X4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0005628 prospore membrane;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0007165 signal transduction;GO:0060627 regulation of vesicle-mediated transport;GO:0008360 regulation of cell shape;GO:0001100 negative regulation of exit from mitosis;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P38853-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38890-1", "uniprot_id": "SET5_YEAST", "mass": 60547.0, "length": 526, "protein_name": "Histone-lysine N-methyltransferase SET5", "gene_name": "SET5", "organism": "Yeast", "refseq_name": "S-adenosylmethionine-dependent methyltransferase", "refseq_ac": "NP_012077", "gene_names_uniprotkb": "SET5", "gene_names_refseq": "SET5", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SET5; 2.1.1.-; SET domain-containing protein 5", "protein_names_refseq": "S-adenosylmethionine-dependent methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR207C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;14671320;17287358;18407956;19779198;21177495;22343720;23749301;24374639;29183786;31685550;32597660;33334889;33491328;8091229;9171100", "class_list": "", "function": "(Microbial infection) Acts as a virus host factor involved in the replication of positive-strand RNA viruses like the MBV., [UniProtKB, PubMed]; Histone methyltransferase that monomethylates 'Lys-5', 'Lys-8' and 'Lys-12' of histone H4 (H4K5me1, H4K8me1 and H4K12me1, respectively), thereby controlling gene expression and remodeling chromatin structures (PubMed:22343720). Functions together with the chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses (PubMed:22343720)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLF6", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0042054 histone methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000723 telomere maintenance;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38915-1", "uniprot_id": "SPT8_YEAST", "mass": 66190.0, "length": 602, "protein_name": "SAGA complex subunit SPT8", "gene_name": "SPT8", "organism": "Yeast", "refseq_name": "SAGA complex subunit SPT8", "refseq_ac": "NP_013156", "gene_names_uniprotkb": "SPT8; L2144", "gene_names_refseq": "SPT8", "protein_names_uniprotkb": "SAGA complex subunit SPT8; Suppressor of Ty protein 8; Transcription factor SPT8", "protein_names_refseq": "SAGA complex subunit SPT8", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR055C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10026213;10611242;10864329;11914276;12370284;14562106;15132995;15260971;17287358;17563356;18407956;21126336;21177495;22218487;23749301;24374639;25216679;28918903;32597660;33481703;33491328;8088510;9169871;9674426;9858534", "class_list": "", "function": "Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:12370284, PubMed:9858534). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). During SAGA-mediated transcriptional inhibition, SPT3 and SPT8 prevent binding of TBP to the TATA box (PubMed:10611242, PubMed:15132995)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VY57", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000124 SAGA complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38927-1", "uniprot_id": "REV7_YEAST", "mass": 28760.0, "length": 245, "protein_name": "DNA polymerase zeta processivity subunit", "gene_name": "REV7", "organism": "Yeast", "refseq_name": "Rev7p", "refseq_ac": "NP_012127", "gene_names_uniprotkb": "REV7", "gene_names_refseq": "REV7", "protein_names_uniprotkb": "DNA polymerase zeta processivity subunit; Revertibility protein 7", "protein_names_refseq": "Rev7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL139C); (R-SCE-110312)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10931348;11316789;16452144;18242152;18603483;20388628;21126336;24049079;24374639;7871890;8658138;9169870", "class_list": "", "function": "Processivity subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS) (PubMed:7871890, PubMed:8658138, PubMed:11316789, PubMed:20388628). Has a role in the bypass of abasic sites and T-T (6-4) UV photoproducts; this process is dependent on the REV1 non-catalytic activity (PubMed:10931348, PubMed:11316789). Together with deoxycytidyl transferase REV1, involved in translesion synthesis of the 1,N6-ethenoadenine DNA adduct; the deoxycytidyl transferase catalyzes insertion of cytosine opposite the lesion, followed by extension synthesis by DNA polymerase zeta (PubMed:20388628). REV1 and DNA polymerase zeta are similarly activated when replication forks are stalled at non-canonical hairpin DNA structures; REV1 incorporates a cytosine across from the base of the structure, which triggers a template-switching event that allows for hairpin bypass, but is highly mutagenic due to the use of an ectopic DNA template and the involvement of the low-fidelity DNA polymerase zeta (PubMed:24049079). Also functions in the mitochondrion (PubMed:16452144)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVE7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000785 chromatin;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0042276 error-prone translesion synthesis;GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38927-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38931-1", "uniprot_id": "SSN2_YEAST", "mass": 160001.0, "length": 1420, "protein_name": "Mediator of RNA polymerase II transcription subunit 13", "gene_name": "SSN2", "organism": "Yeast", "refseq_name": "Ssn2p", "refseq_ac": "NP_010731", "gene_names_uniprotkb": "SSN2; MED13; NUT8; RYE3; SCA1; SRB9; UME2", "gene_names_refseq": "MED13; NUT8; RYE3; SCA1; SRB9; SSN2; SSX5; UME2", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13; Mediator complex subunit 13; Protein SCA1; Suppressor of RNA polymerase B SSN2", "protein_names_refseq": "Ssn2p", "tax_id": 559292, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); autosomal dominant intellectual developmental disorder 61 (Disease Ontology:DOID:0061034); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YDR443C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "12200444;15225552;15477388;15601835;16076843;16109375;16630888;16751660;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21078689;22218487;23749301;24374639;29212878;30175106;32597660;33229814;33481703;33491328;33933450;7774808;8725217;9169867", "class_list": "", "function": "Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VT69", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P38931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39009-1", "uniprot_id": "DUN1_YEAST", "mass": 58633.0, "length": 513, "protein_name": "DNA damage response protein kinase DUN1", "gene_name": "DUN1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase DUN1", "refseq_ac": "NP_010182", "gene_names_uniprotkb": "DUN1; D2370", "gene_names_refseq": "DUN1", "protein_names_uniprotkb": "DNA damage response protein kinase DUN1; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase DUN1", "tax_id": 559292, "disease": "female breast cancer (Disease Ontology:DOID:0050671); Li-Fraumeni syndrome 2 (Disease Ontology:DOID:0111504); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); male breast cancer (Disease Ontology:DOID:1614); embryonal carcinoma (Disease Ontology:DOID:3308); osteosarcoma (Disease Ontology:DOID:3347); seminoma (Disease Ontology:DOID:4440); congestive heart failure (Disease Ontology:DOID:6000); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YDL101C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11904430;11953437;12967660;14562106;17114794;17287358;17563356;18407956;19795423;19823750;20190278;20489023;21126336;23749301;24374639;26970775;32597660;33481703;33491328;33600490;8261511;8896274;8923743;9169867", "class_list": "", "function": "Transducer of the DNA damage signal. Phosphorylates SML1 on serine residues. Cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 40, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRP9", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000077 DNA damage checkpoint signaling;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P39009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39109-1", "uniprot_id": "YCFI_YEAST", "mass": 171121.0, "length": 1515, "protein_name": "Metal resistance protein YCF1", "gene_name": "YCF1", "organism": "Yeast", "refseq_name": "ATP-binding cassette glutathione S-conjugate transporter YCF1", "refseq_ac": "NP_010419", "gene_names_uniprotkb": "YCF1; YD9302.11C", "gene_names_refseq": "YCF1", "protein_names_uniprotkb": "Metal resistance protein YCF1; 7.2.2.2; 7.6.2.3; ABC-type Cd(2+) transporter; ABC-type glutathione-S-conjugate transporter; Yeast cadmium factor 1", "protein_names_refseq": "ATP-binding cassette glutathione S-conjugate transporter YCF1", "tax_id": 559292, "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); autosomal dominant nonsyndromic deafness 77 (Disease Ontology:DOID:0112168); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); hyperprolactinemia (Disease Ontology:DOID:12700); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); drug-induced hepatitis (Disease Ontology:DOID:2044); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); bilirubin metabolic disorder (Disease Ontology:DOID:2741); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YDR135C); (R-SCE-159418); (R-SCE-1660661); (R-SCE-189483); (R-SCE-2142691); (R-SCE-382556); (R-SCE-9707564); (R-SCE-9749641); (R-SCE-9753281); (R-SCE-9754706); (R-SCE-9758890)", "pathway_count": 11, "publication_count": 29, "publication_id_list": "10790694;14562106;15556603;15665377;16847258;17287358;17330950;17563356;18407956;18667437;19684113;19779198;19795423;19823750;20702584;20812950;21126336;21177495;22218487;22449970;23749301;24374639;30516470;32597660;33481703;33491328;7521334;8626454;9169867", "class_list": "", "function": "Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSB9;Q03905", "ec_number_list": "7.2.2.21;7.6.2.3;7.2.2.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0140359 ABC-type transporter activity;GO:0008551 P-type cadmium transporter activity", "go_cellular_component": "GO:0045121 membrane raft;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0055085 transmembrane transport;GO:0046686 response to cadmium ion;GO:0045454 cell redox homeostasis;GO:0010038 response to metal ion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P39109-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39678-1", "uniprot_id": "MBP1_YEAST", "mass": 93908.0, "length": 833, "protein_name": "Transcription factor MBP1", "gene_name": "MBP1", "organism": "Yeast", "refseq_name": "transcription factor MBP1", "refseq_ac": "NP_010227", "gene_names_uniprotkb": "MBP1", "gene_names_refseq": "MBP1", "protein_names_uniprotkb": "Transcription factor MBP1; MBF subunit p120", "protein_names_refseq": "transcription factor MBP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL056W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;17330950;17563356;18160399;18407956;19779198;19795423;19823750;20702584;21126336;23749301;24374639;32597660;33229814;33481703;33491328;8372350;8821656;9083114;9169867;9299332", "class_list": "", "function": "Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VRU0", "ec_number_list": "", "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0030907 MBF transcription complex;GO:0033309 SBF transcription complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0000082 G1/S transition of mitotic cell cycle;GO:1990145 maintenance of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P39678-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39717-1", "uniprot_id": "GPB2_YEAST", "mass": 98656.0, "length": 880, "protein_name": "Guanine nucleotide-binding protein subunit beta 2", "gene_name": "GPB2", "organism": "Yeast", "refseq_name": "Gpb2p", "refseq_ac": "NP_009345", "gene_names_uniprotkb": "GPB2; KRH1", "gene_names_refseq": "GPB2; KRH1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta 2; Gbeta mimic kelch protein 2", "protein_names_refseq": "Gpb2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL056W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12150916;12538771;14562095;15665377;16278446;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;7731988", "class_list": "", "function": "Beta subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPG2;P39716", "ec_number_list": "", "go_molecular_function": "GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0010255 glucose mediated signaling pathway;GO:0001403 invasive growth in response to glucose limitation;GO:0007124 pseudohyphal growth;GO:0030437 ascospore formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P39717-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39735-1", "uniprot_id": "SAW1_YEAST", "mass": 29770.0, "length": 261, "protein_name": "Single-strand annealing weakened protein 1", "gene_name": "SAW1", "organism": "Yeast", "refseq_name": "DNA-binding protein SAW1", "refseq_ac": "NP_009375", "gene_names_uniprotkb": "SAW1", "gene_names_refseq": "SAW1", "protein_names_uniprotkb": "Single-strand annealing weakened protein 1", "protein_names_refseq": "DNA-binding protein SAW1", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL027W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;17322287;17989249;18471978;24374639;7731988", "class_list": "", "function": "Catalyzes 3'-non-homologous tail removal of RAD1/RAD10-dependent single-strand annealing recombination intermediates. Plays a key role in targeting RAD1/RAD10 complex to 3'-flap cleavage substrate in recombination. Also contributes to the integrity of ribosomal DNA arrays., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPJ1", "ec_number_list": "", "go_molecular_function": "GO:0000403 Y-form DNA binding;GO:0000405 bubble DNA binding;GO:0070337 3'-flap-structured DNA binding;GO:0070338 5'-flap-structured DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39744-1", "uniprot_id": "NOC2_YEAST", "mass": 81601.0, "length": 710, "protein_name": "Nucleolar complex protein 2", "gene_name": "NOC2", "organism": "Yeast", "refseq_name": "mRNA-binding ribosome synthesis protein NOC2", "refseq_ac": "NP_014849", "gene_names_uniprotkb": "NOC2; YOX001", "gene_names_refseq": "NOC2", "protein_names_uniprotkb": "Nucleolar complex protein 2", "protein_names_refseq": "mRNA-binding ribosome synthesis protein NOC2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR206W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11371346;14562106;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22218487;2263475;23749301;24374639;30516470;32597660;33481703;33491328;9169874", "class_list": "", "function": "Involved in the intranuclear transport of ribosomal precursors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R2;Q08625", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P39744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39935-1", "uniprot_id": "IF4F1_YEAST", "mass": 107101.0, "length": 952, "protein_name": "Eukaryotic initiation factor 4F subunit p150", "gene_name": "TIF4631", "organism": "Yeast", "refseq_name": "translation initiation factor eIF4G", "refseq_ac": "NP_011678", "gene_names_uniprotkb": "TIF4631", "gene_names_refseq": "TIF4631", "protein_names_uniprotkb": "Eukaryotic initiation factor 4F subunit p150; Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 1; eIF-4F p150; eIF4F p150; eIF4G1; mRNA cap-binding protein complex subunit p150", "protein_names_refseq": "translation initiation factor eIF4G", "tax_id": 559292, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); renovascular hypertension (Disease Ontology:DOID:1591)", "pathway": " (sce:YGR162W); (R-SCE-156827); (R-SCE-166208); (R-SCE-429947); (R-SCE-72649); (R-SCE-72662); (R-SCE-72702); (R-SCE-975956); (R-SCE-975957)", "pathway_count": 9, "publication_count": 37, "publication_id_list": "10357826;10944120;11741542;14562095;14562106;14675538;17287358;17322287;17330950;17563356;18407956;18606994;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23222640;23749301;24374639;29438499;30516470;31455721;32027465;32597660;33229814;33481703;33491328;33856219;8336723;9169869;9256432;9290212;9702200", "class_list": "", "function": "Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus. Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. TIF4631 is probably essential when TIF4632 is missing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 67, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "D6VUU6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0001671 ATPase activator activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000932 P-body;GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0005840 ribosome", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006413 translational initiation;GO:0042149 cellular response to glucose starvation;GO:0006446 regulation of translational initiation;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "P39935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39936-1", "uniprot_id": "IF4F2_YEAST", "mass": 103899.0, "length": 914, "protein_name": "Eukaryotic initiation factor 4F subunit p130", "gene_name": "TIF4632", "organism": "Yeast", "refseq_name": "translation initiation factor eIF4G", "refseq_ac": "NP_011466", "gene_names_uniprotkb": "TIF4632", "gene_names_refseq": "TIF4632", "protein_names_uniprotkb": "Eukaryotic initiation factor 4F subunit p130; Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 2; eIF-4F p130; eIF4F p130; eIF4G2; mRNA cap-binding protein complex subunit p130", "protein_names_refseq": "translation initiation factor eIF4G", "tax_id": 559292, "disease": "hypertension (Disease Ontology:DOID:10763); renovascular hypertension (Disease Ontology:DOID:1591)", "pathway": " (sce:YGL049C); (R-SCE-156827); (R-SCE-166208); (R-SCE-429947); (R-SCE-72649); (R-SCE-72662); (R-SCE-72702); (R-SCE-975956); (R-SCE-975957)", "pathway_count": 9, "publication_count": 33, "publication_id_list": "10357826;11741542;14562095;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;27821475;28270554;30516470;31208443;32027465;32597660;33229814;33481703;33491328;34965436;8336723;9003792;9169869;9234674;9256432;9418852", "class_list": "", "function": "Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus. Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability. TIF4632 is probably essential when TIF4631 is missing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 35, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VU91", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0001671 ATPase activator activity;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0000932 P-body;GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0005840 ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006413 translational initiation;GO:0042149 cellular response to glucose starvation;GO:0006446 regulation of translational initiation;GO:0034063 stress granule assembly;GO:1901195 positive regulation of formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P39936-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39940-1", "uniprot_id": "RSP5_YEAST", "mass": 91816.0, "length": 809, "protein_name": "E3 ubiquitin-protein ligase RSP5", "gene_name": "RSP5", "organism": "Yeast", "refseq_name": "NEDD4 family E3 ubiquitin-protein ligase", "refseq_ac": "NP_011051", "gene_names_uniprotkb": "RSP5; MDP1; NPI1; SYGP-ORF41", "gene_names_refseq": "HPG1; MDP1; MUT2; NPI1; RSP5; SMM1; UBY1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RSP5; 2.3.2.26; HECT-type E3 ubiquitin transferase RSP5; Reverses SPT-phenotype protein 5", "protein_names_refseq": "NEDD4 family E3 ubiquitin-protein ligase", "tax_id": 559292, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); Liddle syndrome (Disease Ontology:DOID:0050477); stroke (Disease Ontology:DOID:0051061); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (sce:YER125W); (R-SCE-9013406); (R-SCE-9013420); (R-SCE-983168)", "pathway_count": 4, "publication_count": 33, "publication_id_list": "12163175;12821147;14560004;15020711;15086794;15247235;15933713;16864574;17079730;17213653;19779198;19795423;19823750;19920177;20489023;21399621;22000681;22106047;23749301;24374639;26548973;30610170;30893611;32597660;33229814;33481703;33491328;7708685;8596462;8668140;9169868;9858558;9931424", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:15933713, PubMed:19920177, PubMed:30893611, PubMed:7708685). Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other cell surface proteins like GAP1, FUR4, MAL61, PMA1 and STE2 (PubMed:8596462). The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription, pressure-induced differential regulation of the two tryptophan permeases TAT1 and TAT2 and sorting efficiency into multivesicular bodies (PubMed:12821147, PubMed:14560004, PubMed:15020711, PubMed:15247235, PubMed:16864574, PubMed:17079730, PubMed:9931424). The RSP5-UBA1-UBC5 ubiquitin ligase complex ubiquitinates RPO21 forming 'Lys-63'-linked polyubiquitin chains (PubMed:19920177, PubMed:9858558). Plays a role in tolerance to o-dinitrobenzene (PubMed:12163175). Involved in actin cytoskeleton organization and dynamics (PubMed:22000681). Ubiquitinates the LAS17-binding proteins LSB1 and PIN3/LSB2 without directing them for degradation and affects LAS17 levels in a SLA1-dependent and LSB1/2-independent manner (PubMed:22000681). Also involved in the degradation of non-functional 18S rRNAs in response to stalled ribosomes by mediating polyubiquitination of monoubiquitinated RPS3/uS3: mediates formation of 'Lys-63'-linked polyubiquitin chains on monoubiquitined RPS3/uS3, promoting the degradation of non-functional 18S rRNAs (PubMed:30893611)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D3DM31", "ec_number_list": "2.3.2.23;3.6.5.2;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;3.4.-.-;2.7.11.1;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0070651 nonfunctional rRNA decay;GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:2000232 regulation of rRNA processing", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P39940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39958-1", "uniprot_id": "GDI1_YEAST", "mass": 51206.0, "length": 451, "protein_name": "Rab GDP-dissociation inhibitor", "gene_name": "GDI1", "organism": "Yeast", "refseq_name": "Gdi1p", "refseq_ac": "NP_011062", "gene_names_uniprotkb": "GDI1; SEC19", "gene_names_refseq": "GDI1; SEC19", "protein_names_uniprotkb": "Rab GDP-dissociation inhibitor; Rab GDI; Secretory pathway GDP dissociation inhibitor", "protein_names_refseq": "Gdi1p", "tax_id": 559292, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 41 (Disease Ontology:DOID:0112058); Down syndrome (Disease Ontology:DOID:14250); cancer (Disease Ontology:DOID:162); psychotic disorder (Disease Ontology:DOID:2468)", "pathway": " (sce:YER136W); (R-SCE-6798695); (R-SCE-8876198)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10394895;11118206;14562095;14562106;14576435;16395334;17563356;18407956;18426803;19779198;24374639;33491328;8157010;9169868", "class_list": "", "function": "Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway (PubMed:8157010). Extracts GDP-bound YPT7 from vacuolar membranes, antagonizing vacuolar membrane fusion (PubMed:11118206)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM41", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005093 Rab GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P39958-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40073-1", "uniprot_id": "SHO1_YEAST", "mass": 41126.0, "length": 367, "protein_name": "High osmolarity signaling protein SHO1", "gene_name": "SHO1", "organism": "Yeast", "refseq_name": "osmosensor SHO1", "refseq_ac": "NP_011043", "gene_names_uniprotkb": "SHO1; SSU81", "gene_names_refseq": "SHO1; SSU81", "protein_names_uniprotkb": "High osmolarity signaling protein SHO1; Osmosensor SHO1; Suppressor of SUA8-1 mutation; Synthetic high osmolarity-sensitive protein 1", "protein_names_refseq": "osmosensor SHO1", "tax_id": 559292, "disease": "", "pathway": " (sce:YER118C)", "pathway_count": 1, "publication_count": 36, "publication_id_list": "10762242;10931333;10970855;10980703;11084293;11922108;12374868;12455951;12511654;14562106;14595107;14668868;15020407;15200958;15200959;15256499;15665377;16778768;16847258;17363249;18407956;18480263;18854322;19318625;19439450;19779198;21177495;23749301;24374639;32597660;33481703;33491328;7624781;9169868;9180081;9744864", "class_list": "", "function": "Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DM24", "ec_number_list": "", "go_molecular_function": "GO:0005078 MAP-kinase scaffold activity;GO:0005034 osmosensor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0044697 HICS complex", "go_biological_process": "GO:0007231 osmosensory signaling pathway;GO:0030010 establishment of cell polarity;GO:0030833 regulation of actin filament polymerization;GO:1902410 mitotic cytokinetic process;GO:0001402 signal transduction involved in filamentous growth", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P40073-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40087-1", "uniprot_id": "DDI1_YEAST", "mass": 47354.0, "length": 428, "protein_name": "DNA damage-inducible protein 1", "gene_name": "DDI1", "organism": "Yeast", "refseq_name": "Ddi1p", "refseq_ac": "NP_011070", "gene_names_uniprotkb": "DDI1; VSM1", "gene_names_refseq": "DDI1; VSM1", "protein_names_uniprotkb": "DNA damage-inducible protein 1; 3.4.23.-; v-SNARE-master 1", "protein_names_refseq": "Ddi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER143W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10330187;11238935;11700052;11713673;12051757;12872131;12925750;14557538;14562106;15452273;15964793;16478980;17010377;17144915;17322287;17330950;17563356;18407956;19779198;20702584;21266539;23749301;24374639;32597660;33481703;33491328;9157248;9169868;9826765", "class_list": "", "function": "Aspartic protease (PubMed:21266539). Appears to act as negative regulator of constitutive exocytosis (PubMed:10330187, PubMed:12051757). May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly (PubMed:12925750). Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation (PubMed:16478980, PubMed:17144915). Required for S-phase checkpoint control (PubMed:11238935, PubMed:17144915)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DM50", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0000149 SNARE binding;GO:0043130 ubiquitin binding;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006508 proteolysis;GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P40087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40091-1", "uniprot_id": "PEA2_YEAST", "mass": 48165.0, "length": 420, "protein_name": "Protein PEA2", "gene_name": "PEA2", "organism": "Yeast", "refseq_name": "Pea2p", "refseq_ac": "NP_011076", "gene_names_uniprotkb": "PEA2; PPF2", "gene_names_refseq": "DFG9; PEA2; PPF2", "protein_names_uniprotkb": "Protein PEA2; Protein PPF2", "protein_names_refseq": "Pea2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER149C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11875433;14562106;15087486;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8909546;9169868", "class_list": "", "function": "Localized to sites of polarized growth and is required for efficient mating and bipolar budding., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DM56;Q70DC9;Q70DD1;Q70DD2;Q70DD3;Q70DD4;Q70DD6;Q70DD7;Q70DD8", "ec_number_list": "", "go_molecular_function": "GO:0031489 myosin V binding", "go_cellular_component": "GO:0030427 site of polarized growth;GO:0000131 incipient cellular bud site;GO:0000133 polarisome;GO:0005933 cellular bud;GO:0005934 cellular bud tip", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0032880 regulation of protein localization;GO:0071474 cellular hyperosmotic response;GO:0006903 vesicle targeting;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P40091-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40160-1", "uniprot_id": "RIO2_YEAST", "mass": 49125.0, "length": 425, "protein_name": "Serine/threonine-protein kinase RIO2", "gene_name": "RIO2", "organism": "Yeast", "refseq_name": "protein kinase RIO2", "refseq_ac": "NP_014192", "gene_names_uniprotkb": "RIO2; N1342", "gene_names_refseq": "RIO2", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO2; 2.7.11.1", "protein_names_refseq": "protein kinase RIO2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL207W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12612080;12628929;12690111;14562106;15167894;16159874;16738661;18407956;20489023;24374639;33481703;33491328;34965436;7725799;9169873", "class_list": "", "function": "Required for the final endonucleolytic cleavage of 20S pre-rRNA at site D in the cytoplasm, converting it into the mature 18S rRNA. Involved in normal export of the pre-40S particles from the nucleus to the cytoplasm. No longer associates with pre-40S subunits in RPS19 disruptions, suggesting it acts after the ribosomal protein in 18S rRNA maturation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Y3", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;2.1.1.309;3.1.26.-;2.7.11.21;2.7.1.67;3.1.26.5;3.6.-.-;3.1.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0046830 positive regulation of RNA import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40160-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40161-1", "uniprot_id": "RT106_YEAST", "mass": 51621.0, "length": 455, "protein_name": "Histone chaperone RTT106", "gene_name": "RTT106", "organism": "Yeast", "refseq_name": "Rtt106p", "refseq_ac": "NP_014193", "gene_names_uniprotkb": "RTT106; N1346", "gene_names_refseq": "RTT106", "protein_names_uniprotkb": "Histone chaperone RTT106; Regulator of Ty1 transposition protein 106", "protein_names_refseq": "Rtt106p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL206C)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "11779788;14562095;14562106;16157874;17410207;18407956;19683497;19779198;19795423;19823750;20007951;20188666;21444721;21698254;21763693;21978826;22128187;22156209;22198837;22307274;22814378;23749301;24374639;25406467;30516470;32597660;33481703;33491328;34965436;7725799;9169873", "class_list": "", "function": "Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by directly recruiting the SWI/SNF and RSC chromatin remodeling complexes to the histone genes in a cell cycle dependent manner. In cooperation with HIR and ASF1, creates a repressive structure at the core histone gene promoter and contributes to their repression outside of S phase. Involved in regulation of Ty1 transposition., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Y4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0006368 transcription elongation by RNA polymerase II;GO:0006335 DNA replication-dependent chromatin assembly;GO:0032196 transposition", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P40161-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40202-1", "uniprot_id": "CCS1_YEAST", "mass": 27330.0, "length": 249, "protein_name": "Superoxide dismutase 1 copper chaperone", "gene_name": "CCS1", "organism": "Yeast", "refseq_name": "copper chaperone CCS1", "refseq_ac": "NP_013752", "gene_names_uniprotkb": "CCS1; LYS7; YM9532.03C", "gene_names_refseq": "CCS1; LYS7", "protein_names_uniprotkb": "Superoxide dismutase 1 copper chaperone", "protein_names_refseq": "copper chaperone CCS1", "tax_id": 559292, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cataract (Disease Ontology:DOID:83)", "pathway": " (sce:YMR038C); (R-SCE-3299685)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10426947;10736160;11101286;11500508;11524675;14562106;17322287;17330950;18948262;19795423;19823750;22984289;23749301;24374639;30516470;33481703;33491328;7557423;9169872;9295278", "class_list": "", "function": "Copper chaperone for apo superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to apo-SOD1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZL3", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0016532 superoxide dismutase copper chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0019430 removal of superoxide radicals;GO:0006825 copper ion transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40217-1", "uniprot_id": "EIF3I_YEAST", "mass": 38755.0, "length": 347, "protein_name": "Eukaryotic translation initiation factor 3 subunit I", "gene_name": "TIF34", "organism": "Yeast", "refseq_name": "translation initiation factor eIF3 subunit i", "refseq_ac": "NP_013866", "gene_names_uniprotkb": "TIF34; YM9375.16C", "gene_names_refseq": "TIF34", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 39 kDa subunit; eIF-3 39 kDa subunit; eIF3 p39; eIF3i", "protein_names_refseq": "translation initiation factor eIF3 subunit i", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR146C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "14562106;16581774;17322287;18407956;18599441;23749301;24374639;32597660;33481703;33491328;8972194;9169872;9671501", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZW8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:0002188 translation reinitiation;GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40217-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40318-1", "uniprot_id": "DOA10_YEAST", "mass": 151455.0, "length": 1319, "protein_name": "ERAD-associated E3 ubiquitin-protein ligase DOA10", "gene_name": "SSM4", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase SSM4", "refseq_ac": "NP_012234", "gene_names_uniprotkb": "SSM4; DOA10; YI3299.01C; YI9905.18C", "gene_names_refseq": "DOA10; KIS3; SSM4", "protein_names_uniprotkb": "ERAD-associated E3 ubiquitin-protein ligase DOA10; 2.3.2.27; RING-type E3 ubiquitin transferase DOA10", "protein_names_refseq": "E3 ubiquitin-protein ligase SSM4", "tax_id": 559292, "disease": "familial adult myoclonic epilepsy 3 (Disease Ontology:DOID:0111695)", "pathway": " (sce:YIL030C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11641273;16179952;16179953;16373356;16437165;16873066;17051211;18407956;18812321;19779198;20110468;20159987;20702584;21126336;22218487;22814378;23749301;24374639;25454947;31445887;32597660;33481703;33491328;7816042;9169870", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC6 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC) (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Component of the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains (PubMed:16873066). ERAD-C substrates are ubiquitinated through DOA10 in conjunction with the E2 ubiquitin-conjugating enzymes UBC6 and UBC7-CUE1 (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Also functions in the ERAD-R pathway, together with DFM1 and YPF1, this pathway regulates protein levels in response to signaling (PubMed:25454947). Ubiquitinated substrates are then removed to the cytosol via the action of the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex and targeted to the proteasome (PubMed:11641273, PubMed:16179952, PubMed:16437165, PubMed:16873066, PubMed:17051211, PubMed:18812321, PubMed:20110468). Also recognizes the N-terminally acetylated residue of proteins as degradation signal (degron) (PubMed:20110468). N-terminally acetylated target proteins include MATALPHA2, TBF1, SLK19, YMR090W, HIS3, HSP104, UBP6 and ARO8 (PubMed:20110468). Catalyzes ubiquitination of mislocalized tail-anchored proteins that are extracted from the mitochondrion membrane by MSP1: following extraction, mistargeted proteins are transferred to the endoplasmic reticulum, where they are ubiquitinated by DOA10 and degraded by the proteasome (PubMed:31445887)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVQ1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0036503 ERAD pathway;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P40318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40433-1", "uniprot_id": "6P21_YEAST", "mass": 93417.0, "length": 827, "protein_name": "6-phosphofructo-2-kinase 1", "gene_name": "PFK26", "organism": "Yeast", "refseq_name": "6-phosphofructo-2-kinase", "refseq_ac": "NP_012159", "gene_names_uniprotkb": "PFK26", "gene_names_refseq": "PFK26", "protein_names_uniprotkb": "6-phosphofructo-2-kinase 1; 2.7.1.105; 6PF-2-K 1; Phosphofructokinase 2 I", "protein_names_refseq": "6-phosphofructo-2-kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL107C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "11724581;12755632;14562106;15037628;15665377;1657152;17287358;17322287;17330950;17563356;18407956;1851090;19779198;20702584;21126336;21177495;23749301;24374639;24909858;30516470;32597660;33229814;33481703;33491328;9169870;9308187", "class_list": "", "function": "Synthesis of fructose 2,6-bisphosphate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VVI0", "ec_number_list": "2.7.1.105;3.1.3.46", "go_molecular_function": "GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P40433-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40450-1", "uniprot_id": "BNR1_YEAST", "mass": 156852.0, "length": 1375, "protein_name": "BNI1-related protein 1", "gene_name": "BNR1", "organism": "Yeast", "refseq_name": "formin BNR1", "refseq_ac": "NP_012107", "gene_names_uniprotkb": "BNR1", "gene_names_refseq": "BNR1", "protein_names_uniprotkb": "BNI1-related protein 1", "protein_names_refseq": "formin BNR1", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); autosomal dominant nonsyndromic deafness 1 (Disease Ontology:DOID:0110541); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (sce:YIL159W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;17563356;18407956;19779198;19795423;19823750;20702584;23749301;24374639;32597660;33481703;33491328;9169870;9184220", "class_list": "", "function": "May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVC7", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032153 cell division site;GO:0005935 cellular bud neck;GO:0043332 mating projection tip;GO:0110085 mitotic actomyosin contractile ring", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0051017 actin filament bundle assembly;GO:0045010 actin nucleation;GO:0071474 cellular hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40450-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40955-1", "uniprot_id": "CHS6_YEAST", "mass": 86042.0, "length": 746, "protein_name": "Chitin biosynthesis protein CHS6", "gene_name": "CHS6", "organism": "Yeast", "refseq_name": "Chs6p", "refseq_ac": "NP_012436", "gene_names_uniprotkb": "CHS6; CSD3; J0838", "gene_names_refseq": "CHS6; CSD3", "protein_names_uniprotkb": "Chitin biosynthesis protein CHS6; Protein CSD3", "protein_names_refseq": "Chs6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL099W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;1532231;15715908;16498409;16818716;16855022;17000877;23749301;24374639;33491328;7483851;8641269;9614194", "class_list": "", "function": "Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VW85", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0030140 trans-Golgi network transport vesicle;GO:0034044 exomer complex", "go_biological_process": "GO:0015031 protein transport;GO:0006893 Golgi to plasma membrane transport;GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40955-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41808-1", "uniprot_id": "SMK1_YEAST", "mass": 44300.0, "length": 388, "protein_name": "Sporulation-specific mitogen-activated protein kinase SMK1", "gene_name": "SMK1", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase SMK1", "refseq_ac": "NP_015379", "gene_names_uniprotkb": "SMK1; YP9499.10", "gene_names_refseq": "SMK1", "protein_names_uniprotkb": "Sporulation-specific mitogen-activated protein kinase SMK1; 2.7.11.24; MAP kinase SMK1", "protein_names_refseq": "mitogen-activated protein kinase SMK1", "tax_id": 559292, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (sce:YPR054W); (R-SCE-4086398); (R-SCE-5687128)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16116083;24374639;26246597;28223369;29118076;32423992;7958885;9169875", "class_list": "", "function": "Required for spore wall assembly. Required for proper deposition of the two outer layers of the spore wall, the chitosan and dityrosine layers. Negatively regulates GSC2, an alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Participates in a developmentally regulated signal transduction pathway that coordinates cytodifferentiation events with the transcriptional program., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W460", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.1.3.48;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0070056 prospore membrane leading edge", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0008360 regulation of cell shape;GO:0030476 ascospore wall assembly;GO:1904853 protein localization to ascospore wall", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P41808-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41811-1", "uniprot_id": "COPB2_YEAST", "mass": 99445.0, "length": 889, "protein_name": "Coatomer subunit beta'", "gene_name": "SEC27", "organism": "Yeast", "refseq_name": "coatomer subunit beta'", "refseq_ac": "NP_011378", "gene_names_uniprotkb": "SEC27; G2827", "gene_names_refseq": "SEC27", "protein_names_uniprotkb": "Coatomer subunit beta'; Beta'-COP; Beta'-coat protein", "protein_names_refseq": "coatomer subunit beta'", "tax_id": 559292, "disease": "primary autosomal recessive microcephaly 19 (Disease Ontology:DOID:0070281); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (sce:YGL137W); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "14562095;14562106;17101773;18407956;19779198;21126336;22814378;23749301;24374639;33481703;33491328;7929113;8405452;8840506;9169869", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU12", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0008298 intracellular mRNA localization;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P41811-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41896-1", "uniprot_id": "T2FB_YEAST", "mass": 46605.0, "length": 400, "protein_name": "Transcription initiation factor IIF subunit beta", "gene_name": "TFG2", "organism": "Yeast", "refseq_name": "transcription factor IIF subunit TFG2", "refseq_ac": "NP_011519", "gene_names_uniprotkb": "TFG2", "gene_names_refseq": "TFG2", "protein_names_uniprotkb": "Transcription initiation factor IIF subunit beta; TFIIF medium subunit; TFIIF-beta; Transcription factor G 54 kDa subunit", "protein_names_refseq": "transcription factor IIF subunit TFG2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR005C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 13, "publication_count": 16, "publication_id_list": "1331085;14562106;17287358;17322287;18407956;19779198;19795423;19823750;21126336;23749301;24374639;30516470;33481703;33491328;7995524;9169869", "class_list": "", "function": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUE2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000166 nucleotide binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005674 transcription factor TFIIF complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0001174 transcriptional start site selection at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P41896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41909-1", "uniprot_id": "PXA1_YEAST", "mass": 100025.0, "length": 870, "protein_name": "Peroxisomal long-chain fatty acid import protein 2", "gene_name": "PXA1", "organism": "Yeast", "refseq_name": "ATP-binding cassette long-chain fatty acid transporter PXA1", "refseq_ac": "NP_015178", "gene_names_uniprotkb": "PXA1; LPI1W; P2607; PAL1; PAT2; SSH2", "gene_names_refseq": "LPI1; PAL1; PAT2; PXA1; SSH2", "protein_names_uniprotkb": "Peroxisomal long-chain fatty acid import protein 2; Peroxisomal ABC transporter 1", "protein_names_refseq": "ATP-binding cassette long-chain fatty acid transporter PXA1", "tax_id": 559292, "disease": "congenital bile acid synthesis defect 5 (Disease Ontology:DOID:0111066); adrenoleukodystrophy (Disease Ontology:DOID:10588); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (sce:YPL147W); (R-SCE-1369062); (R-SCE-2046105); (R-SCE-2046106); (R-SCE-390247); (R-SCE-9603798)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "23749301;24374639;33491328;35127709;7597071;8647887;8670886;8948103;9169875", "class_list": "", "function": "Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix (PubMed:8670886). Also plays a role in the peroxisomal uptake of ATP (PubMed:35127709)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W3M2", "ec_number_list": "", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process;GO:0007031 peroxisome organization;GO:0015910 long-chain fatty acid import into peroxisome;GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P41909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41910-1", "uniprot_id": "MAF1_YEAST", "mass": 44733.0, "length": 395, "protein_name": "Repressor of RNA polymerase III transcription MAF1", "gene_name": "MAF1", "organism": "Yeast", "refseq_name": "RNA polymerase III-inhibiting protein MAF1", "refseq_ac": "NP_010288", "gene_names_uniprotkb": "MAF1; YD8119.11C", "gene_names_refseq": "MAF1", "protein_names_uniprotkb": "Repressor of RNA polymerase III transcription MAF1", "protein_names_refseq": "RNA polymerase III-inhibiting protein MAF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR005C); (R-SCE-8943724)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12504022;14562106;17005718;17287358;17330950;18407956;19299514;19684113;19779198;20702584;21126336;21177495;21383183;22814378;23749301;24374639;32597660;33481703;33491328;9055829;9169867", "class_list": "", "function": "Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 48, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRZ3", "ec_number_list": "", "go_molecular_function": "GO:0000994 RNA polymerase III core binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016480 negative regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P41910-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43568-1", "uniprot_id": "CAK1_YEAST", "mass": 42186.0, "length": 368, "protein_name": "Serine/threonine-protein kinase CAK1", "gene_name": "CAK1", "organism": "Yeast", "refseq_name": "cyclin-dependent protein kinase-activating kinase CAK1", "refseq_ac": "NP_116624", "gene_names_uniprotkb": "CAK1; CIV1", "gene_names_refseq": "CAK1; CIV1", "protein_names_uniprotkb": "Serine/threonine-protein kinase CAK1; 2.7.11.22; CDK-activating kinase", "protein_names_refseq": "cyclin-dependent protein kinase-activating kinase CAK1", "tax_id": 559292, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); primary autosomal recessive microcephaly 12 (Disease Ontology:DOID:0070284); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cystinosis (Disease Ontology:DOID:1064); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); islet cell tumor (Disease Ontology:DOID:1799); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); non-functioning pancreatic endocrine tumor (Disease Ontology:DOID:7698); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); type 2 diabetes mellitus (Disease Ontology:DOID:9352); encephalitis (Disease Ontology:DOID:9588); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YFL029C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18407956;24374639;33491328;7670463;8752210", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTK1", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0097472 cyclin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0051321 meiotic cell cycle;GO:0060633 negative regulation of transcription initiation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P43568-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43573-1", "uniprot_id": "BUD27_YEAST", "mass": 91422.0, "length": 796, "protein_name": "Bud site selection protein 27", "gene_name": "BUD27", "organism": "Yeast", "refseq_name": "prefoldin-like protein", "refseq_ac": "NP_683715", "gene_names_uniprotkb": "BUD27; URI", "gene_names_refseq": "BUD27; URI1", "protein_names_uniprotkb": "Bud site selection protein 27", "protein_names_refseq": "prefoldin-like protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL023W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11452010;12663529;14562095;14562106;14615539;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;21725298;22218487;22814378;23749301;24374639;30516470;32597660;33481703;33491328;7670463", "class_list": "", "function": "Involved in gene expression controlled by TOR kinase and nutrient signaling. May also be involved in positioning the proximal bud pole signal., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTK7", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006457 protein folding;GO:0006364 rRNA processing;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P43573-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43581-1", "uniprot_id": "HXT10_YEAST", "mass": 60662.0, "length": 546, "protein_name": "Hexose transporter HXT10", "gene_name": "HXT10", "organism": "Yeast", "refseq_name": "hexose transporter HXT10", "refseq_ac": "NP_116644", "gene_names_uniprotkb": "HXT10", "gene_names_refseq": "HXT10", "protein_names_uniprotkb": "Hexose transporter HXT10", "protein_names_refseq": "hexose transporter HXT10", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL011W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16847258;19779198;23749301;24374639;33491328;7670463", "class_list": "", "function": "Probable glucose transporter., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VTL8", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43603-1", "uniprot_id": "LSB3_YEAST", "mass": 49344.0, "length": 459, "protein_name": "LAS seventeen-binding protein 3", "gene_name": "LSB3", "organism": "Yeast", "refseq_name": "Lsb3p", "refseq_ac": "NP_219497", "gene_names_uniprotkb": "LSB3; YFR024C", "gene_names_refseq": "LSB3; YFR024C", "protein_names_uniprotkb": "LAS seventeen-binding protein 3; LAS17-binding protein 3", "protein_names_refseq": "Lsb3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR024C-A)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10512884;10734188;11875433;14562095;14562106;15665377;17330950;18407956;19684113;19779198;20702584;21177495;22218487;23749301;24374639;24909858;30516470;32597660;33229814;33481703;33491328;7670463", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VTQ4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030479 actin cortical patch;GO:0005935 cellular bud neck", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0051666 actin cortical patch localization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P43603-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46672-1", "uniprot_id": "ARC1_YEAST", "mass": 42084.0, "length": 376, "protein_name": "tRNA-aminoacylation cofactor ARC1", "gene_name": "ARC1", "organism": "Yeast", "refseq_name": "Arc1p", "refseq_ac": "NP_011410", "gene_names_uniprotkb": "ARC1; G3085; G4P1", "gene_names_refseq": "ARC1", "protein_names_uniprotkb": "tRNA-aminoacylation cofactor ARC1; 3.1.1.-; Acyl-RNA-complex protein 1; G4p1 protein; GU4 nucleic-binding protein 1; P42; ScArc1p; tRNA-interacting factor ARC1", "protein_names_refseq": "Arc1p", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy 3 (Disease Ontology:DOID:0060790); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (sce:YGL105W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11069915;11726524;14562106;15710377;16914447;17131041;17139087;17322287;18407956;24374639;33481703;33491328;40274265;7657649;8895587;9046090;9169869;9659920", "class_list": "", "function": "Binds to tRNA and functions as a cofactor for the methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS). Forms a complex with MetRS and GluRS and increases their affinity for cognate tRNAs due to the presence of a tRNA binding domain in its middle and C-terminal part. Binds specifically G4 quadruplex nucleic acid structures (these are four-stranded right-handed helices, stabilized by guanine base quartets). Also required for cytoplasmic confinement of the synthetases and tRNA (PubMed:11069915, PubMed:17131041, PubMed:8895587, PubMed:9659920). Exhibits Ala-tRNA deacylase activity (PubMed:40274265)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU41", "ec_number_list": "", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0008047 enzyme activator activity;GO:0000049 tRNA binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0017102 methionyl glutamyl tRNA synthetase complex;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006418 tRNA aminoacylation for protein translation;GO:0006424 glutamyl-tRNA aminoacylation;GO:0006431 methionyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P46672-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46674-1", "uniprot_id": "SAC3_YEAST", "mass": 149569.0, "length": 1301, "protein_name": "Nuclear mRNA export protein SAC3", "gene_name": "SAC3", "organism": "Yeast", "refseq_name": "Sac3p", "refseq_ac": "NP_010443", "gene_names_uniprotkb": "SAC3; LEP1; YD8358.13", "gene_names_refseq": "LEP1; SAC3", "protein_names_uniprotkb": "Nuclear mRNA export protein SAC3; Leucine permease transcriptional regulator", "protein_names_refseq": "Sac3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR159W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10517330;12411502;12702719;14562095;14562106;14718168;15311284;17330950;18407956;19779198;19795423;19823750;20702584;23749301;24374639;32597660;33481703;33491328;8873450;9169867", "class_list": "", "function": "Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSD9", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0044614 nuclear pore cytoplasmic filaments;GO:0070390 transcription export complex 2", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P46674-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46683-1", "uniprot_id": "YAR1_YEAST", "mass": 22356.0, "length": 200, "protein_name": "Ankyrin repeat-containing protein YAR1", "gene_name": "YAR1", "organism": "Yeast", "refseq_name": "Yar1p", "refseq_ac": "NP_015085", "gene_names_uniprotkb": "YAR1", "gene_names_refseq": "YAR1", "protein_names_uniprotkb": "Ankyrin repeat-containing protein YAR1", "protein_names_refseq": "Yar1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL239W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;17322287;17330950;22814378;23749301;24374639;3136928;33481703;33491328;34965436;8675027;9169875", "class_list": "", "function": "Required for normal rate of cell proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3D2", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030907 MBF transcription complex;GO:0033309 SBF transcription complex", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032880 regulation of protein localization;GO:0034599 cellular response to oxidative stress;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P46683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47035-1", "uniprot_id": "NET1_YEAST", "mass": 128531.0, "length": 1189, "protein_name": "Nucleolar protein NET1", "gene_name": "NET1", "organism": "Yeast", "refseq_name": "Net1p", "refseq_ac": "NP_012459", "gene_names_uniprotkb": "NET1; CFI1; ESC5; J1038; SRM8", "gene_names_refseq": "CFI1; ESC5; NET1; SRM8", "protein_names_uniprotkb": "Nucleolar protein NET1", "protein_names_refseq": "Net1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL076W)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "11511359;11960554;12056824;12096118;14562106;15273393;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;22362748;23749301;24374639;30516470;32265285;32597660;33229814;33481703;33491328;34088668;34965436;8641269", "class_list": "", "function": "Has a role in chromosome maintenance and is involved in mitotic exit. Inhibits the action of CDC14 by sequestering it in the nucleolus. Also binds to RNA polymerase I and stimulates rRNA synthesis. Influences RDNA chromatin by tethering SIR2 to rDNA in the nucleolus., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 127, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "D6VWA8", "ec_number_list": "", "go_molecular_function": "GO:0000182 rDNA binding;GO:0004864 protein phosphatase inhibitor activity;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030869 RENT complex", "go_biological_process": "GO:0007000 nucleolus organization;GO:1902570 protein localization to nucleolus;GO:0051301 cell division;GO:0000183 rDNA heterochromatin formation;GO:0001100 negative regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P47035-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47069-1", "uniprot_id": "MPS3_YEAST", "mass": 79175.0, "length": 682, "protein_name": "Spindle pole body assembly component MPS3", "gene_name": "MPS3", "organism": "Yeast", "refseq_name": "Mps3p", "refseq_ac": "NP_012515", "gene_names_uniprotkb": "MPS3; J1310; J1315; NEP98; YJL018W", "gene_names_refseq": "MPS3; NEP98; YJL018W", "protein_names_uniprotkb": "Spindle pole body assembly component MPS3; 98 kDa nuclear envelope protein; Monopolar spindle protein 3", "protein_names_refseq": "Mps3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL019W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "12486115;12493774;12748633;12844361;15282802;15355977;16682351;16923827;17245108;17495028;18039933;18585352;19217407;19390086;19390087;19779198;20016273;21518795;22017544;23749301;24374639;28609436;30141044;30417519;32967926;33481703;33491328;34586062;8641269", "class_list": "", "function": "Component of the linker nucleocytoskeleton and cytoskeleton (LINC) complex that regulates telomere movement and meiotic recombination during meiosis (PubMed:17245108, PubMed:18585352, PubMed:32967926). Connects the spindle pole body with the nuclear envelope through its interaction with MPS2 and mediates meiotic bouquet formation and rapid chromosome movements in meiotic prophase (PubMed:16923827, PubMed:17495028, PubMed:22017544). Functions as an integral membrane anchor for telomeres and is a nuclear receptor for the SIR4 pathway of telomere tethering and gene inactivation (PubMed:18039933, PubMed:19390087). Essential for nuclear division and fusion and required for the first step of spindle pole body duplication in G1 (PubMed:12486115, PubMed:12493774). Functions in sister chromatid cohesion establishment (PubMed:15355977, PubMed:16682351). Recruits double-strand breaks (DSBs) to the nuclear periphery for chromosome healing (PubMed:19217407, PubMed:19390086, PubMed:20016273)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWG1;P47070", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0034399 nuclear periphery;GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0007129 homologous chromosome pairing at meiosis;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0045141 meiotic telomere clustering;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P47069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47103-1", "uniprot_id": "CYP7_YEAST", "mass": 45134.0, "length": 393, "protein_name": "Peptidyl-prolyl cis-trans isomerase CYP7", "gene_name": "CPR7", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase CPR7", "refseq_ac": "NP_012566", "gene_names_uniprotkb": "CPR7; J1585", "gene_names_refseq": "CPR7", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase CYP7; 5.2.1.8; PPIase CYP7; Rotamase CYP7", "protein_names_refseq": "peptidylprolyl isomerase CPR7", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR032W); (R-SCE-8939211)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562106;17322287;24374639;33491328;8619316;8641269;8873448", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Plays a major role in negative regulation of the heat shock transcription factor (HSF)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWK5;Q92323", "ec_number_list": "5.2.1.8;3.1.3.16", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47110-1", "uniprot_id": "DPOD3_YEAST", "mass": 40310.0, "length": 350, "protein_name": "DNA polymerase delta subunit 3", "gene_name": "POL32", "organism": "Yeast", "refseq_name": "DNA polymerase delta subunit POL32", "refseq_ac": "NP_012577", "gene_names_uniprotkb": "POL32; J1626", "gene_names_refseq": "POL32; REV5", "protein_names_uniprotkb": "DNA polymerase delta subunit 3", "protein_names_refseq": "DNA polymerase delta subunit POL32", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YJR043C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11568188;14562106;17287358;17322287;18407956;19779198;19795423;19823750;21126336;21177495;23749301;24374639;32597660;33481703;33491328;7668047;8641269;9677405", "class_list": "", "function": "DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWL4", "ec_number_list": "", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0000510 H3-H4 histone complex chaperone activity", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0006278 RNA-templated DNA biosynthetic process;GO:0006272 leading strand elongation;GO:0006273 lagging strand elongation;GO:0006284 base-excision repair;GO:0006259 DNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48365-1", "uniprot_id": "GYP7_YEAST", "mass": 87306.0, "length": 746, "protein_name": "GTPase-activating protein GYP7", "gene_name": "GYP7", "organism": "Yeast", "refseq_name": "GTPase-activating protein GYP7", "refseq_ac": "NP_010047", "gene_names_uniprotkb": "GYP7", "gene_names_refseq": "GYP7", "protein_names_uniprotkb": "GTPase-activating protein GYP7; GAP for YPT7", "protein_names_refseq": "GTPase-activating protein GYP7", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL234C); (R-SCE-8854214)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10091609;10508155;11210571;14562095;14562106;18407956;19779198;23749301;24374639;33491328;9169867", "class_list": "", "function": "GTPase-activating protein (GAP) that most effectively accelerates the intrinsic GTPase activity of Ypt/Rab-type GTPase YPT7 involved in vacuole docking and fusion (PubMed:10091609, PubMed:11210571). It is also active, but to a lesser extent, on YPT31, YPT32, YPT1, YPT6 and SEC4 (PubMed:10091609, PubMed:11210571). Provides a catalytic arginine (arginine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRC2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005770 late endosome", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032889 regulation of vacuole fusion, non-autophagic", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P48365-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48510-1", "uniprot_id": "DSK2_YEAST", "mass": 39346.0, "length": 373, "protein_name": "Ubiquitin domain-containing protein DSK2", "gene_name": "DSK2", "organism": "Yeast", "refseq_name": "ubiquitin domain-containing protein DSK2", "refseq_ac": "NP_014003", "gene_names_uniprotkb": "DSK2; SHE4; YM8021.02", "gene_names_refseq": "DSK2", "protein_names_uniprotkb": "Ubiquitin domain-containing protein DSK2", "protein_names_refseq": "ubiquitin domain-containing protein DSK2", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis type 15 (Disease Ontology:DOID:0060206); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (sce:YMR276W); (R-SCE-8856825)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;15837191;18407956;19779198;22106047;24374639;33481703;33491328;8682868;9169872", "class_list": "", "function": "Involved, with RAD23 in spindle pole body duplication. Involved in the ubiquitin-proteasome proteolytic pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0A3", "ec_number_list": "", "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0030474 spindle pole body duplication;GO:0072665 protein localization to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48510-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48562-1", "uniprot_id": "CLA4_YEAST", "mass": 93909.0, "length": 842, "protein_name": "Serine/threonine-protein kinase CLA4", "gene_name": "CLA4", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase CLA4", "refseq_ac": "NP_014101", "gene_names_uniprotkb": "CLA4; N0450", "gene_names_refseq": "CLA4; ERC10", "protein_names_uniprotkb": "Serine/threonine-protein kinase CLA4; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase CLA4", "tax_id": 559292, "disease": "stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); ductal carcinoma in situ (Disease Ontology:DOID:0060074); non-syndromic X-linked intellectual disability 30 (Disease Ontology:DOID:0112051); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YNL298W); (R-SCE-2029482); (R-SCE-389359); (R-SCE-3928662); (R-SCE-445144); (R-SCE-5627123); (R-SCE-5687128); (R-SCE-9013406); (R-SCE-9013420); (R-SCE-9013424)", "pathway_count": 10, "publication_count": 19, "publication_id_list": "11875433;17330950;17563356;18407956;19684113;19779198;20489023;20702584;23749301;24374639;24909858;32597660;33229814;33481703;33491328;35454186;7649470;8553702;9169873", "class_list": "", "function": "Involved in budding and cytokinesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 53, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6W0P6", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;3.6.5.2;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;2.3.2.26;3.4.-.-;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000131 incipient cellular bud site;GO:0000324 fungal-type vacuole;GO:0005933 cellular bud", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0010629 negative regulation of gene expression;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P48562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48606-1", "uniprot_id": "TBCA_YEAST", "mass": 12379.0, "length": 106, "protein_name": "Tubulin-specific chaperone A", "gene_name": "RBL2", "organism": "Yeast", "refseq_name": "Rbl2p", "refseq_ac": "NP_014908", "gene_names_uniprotkb": "RBL2", "gene_names_refseq": "RBL2", "protein_names_uniprotkb": "Tubulin-specific chaperone A; CFA; Tubulin-folding cofactor A", "protein_names_refseq": "Rbl2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR265W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;15665377;17322287;17563356;18407956;19779198;21177495;22218487;22814378;23749301;24374639;33481703;33491328;7634332;9153759;9169874", "class_list": "", "function": "Tubulin-folding protein; involved in the early step of the tubulin folding pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2W5", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P48606-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49723-1", "uniprot_id": "RIR4_YEAST", "mass": 40055.0, "length": 345, "protein_name": "Ribonucleoside-diphosphate reductase small chain 2", "gene_name": "RNR4", "organism": "Yeast", "refseq_name": "ribonucleotide-diphosphate reductase subunit RNR4", "refseq_ac": "NP_011696", "gene_names_uniprotkb": "RNR4; CRT3", "gene_names_refseq": "CRT3; PSO3; RNR4", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase small chain 2; 1.17.4.1; Ribonucleotide reductase R2 subunit 2; Ribonucleotide reductase small subunit 2", "protein_names_refseq": "ribonucleotide-diphosphate reductase subunit RNR4", "tax_id": 559292, "disease": "mitochondrial DNA depletion syndrome 8a (Disease Ontology:DOID:0080127); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518); urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic cancer (Disease Ontology:DOID:1793); endometrial adenocarcinoma (Disease Ontology:DOID:2870); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YGR180C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10535923;10716984;11526233;12732713;14562106;15196016;15665377;17287358;17322287;17330950;17563356;18407956;18851834;19684113;19779198;20702584;21126336;22106047;22814378;23749301;24374639;32597660;33481703;33491328;9169869;9315671", "class_list": "", "function": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR4 is required for proper folding of RNR2 and assembly with the large subunits., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW4;Q66R92", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005971 ribonucleoside-diphosphate reductase complex", "go_biological_process": "GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P49723-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50875-1", "uniprot_id": "SPT20_YEAST", "mass": 67796.0, "length": 604, "protein_name": "SAGA complex subunit SPT20", "gene_name": "SPT20", "organism": "Yeast", "refseq_name": "Spt20p", "refseq_ac": "NP_014493", "gene_names_uniprotkb": "SPT20; ADA5", "gene_names_refseq": "ADA5; SPT20", "protein_names_uniprotkb": "SAGA complex subunit SPT20; Suppressor of Ty protein 20; Transcription factor SPT20", "protein_names_refseq": "Spt20p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL148C)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10026213;10652329;10864329;12186975;12446794;14562106;15260971;15647753;18407956;19779198;19795423;19823750;20489023;20702584;21177495;23749301;24374639;25216679;28270554;28918903;31969703;32597660;33229814;33481703;33491328;33864814;8553699;8649430;8649431;9154821;9169874;9674426;9885573", "class_list": "", "function": "Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12186975, PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). Involved in RNA processing, required for the IRE1/RLG1-dependent splicing reaction of HAC1 mRNA (PubMed:10652329)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S1", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0036498 IRE1-mediated unfolded protein response;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P50875-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52286-1", "uniprot_id": "SKP1_YEAST", "mass": 22330.0, "length": 194, "protein_name": "Suppressor of kinetochore protein 1", "gene_name": "SKP1", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase subunit SKP1", "refseq_ac": "NP_010615", "gene_names_uniprotkb": "SKP1; CBF3D; D9798.14", "gene_names_refseq": "MGO1; SKP1", "protein_names_uniprotkb": "Suppressor of kinetochore protein 1; Centromere DNA-binding protein complex CBF3 subunit D; E3 ubiquitin ligase complex SCF subunit SKP1", "protein_names_refseq": "SCF ubiquitin ligase subunit SKP1", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (sce:YDR328C); (R-SCE-8854050); (R-SCE-917937); (R-SCE-983168)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "10637232;11283612;11287615;12553912;14562095;14660673;15090617;17322287;17517885;18407956;19684113;19779198;20489023;21177495;21389113;22814378;23749301;24374639;30516470;33481703;33491328;8670864;8706131;8706132;9169867;9346238;9346239;9499404", "class_list": "", "function": "Essential component of the E3 ubiquitin ligase complex SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins like phosphorylated SIC1. Participates in the attachment of chromosomes to the spindle. Acts as a regulatory component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromeres and in several promoters. The association of CBF3C with CBF3D and SGT1 is required for CBF3C activation and CBF3 assembly. SKP1/CBF3D could retrieve cyclins or cyclin-CDK-like proteins into the kinetochore thus providing cell cycle-regulated kinetochore activity. Involved in the regulation of methionine biosynthesis genes. Facilitates association of CDC53 with CDC4 and of ROY1 with YPT52., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSW0;Q07186", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0043291 RAVE complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0012505 endomembrane system;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0031509 subtelomeric heterochromatin formation;GO:0000278 mitotic cell cycle;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P52286-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52918-1", "uniprot_id": "MSN5_YEAST", "mass": 142118.0, "length": 1224, "protein_name": "Protein MSN5", "gene_name": "MSN5", "organism": "Yeast", "refseq_name": "karyopherin MSN5", "refseq_ac": "NP_010622", "gene_names_uniprotkb": "MSN5; D9651.5", "gene_names_refseq": "KAP142; MSN5; STE21", "protein_names_uniprotkb": "Protein MSN5", "protein_names_refseq": "karyopherin MSN5", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); primary ovarian insufficiency (Disease Ontology:DOID:5426); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (sce:YDR335W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;17203074;22218487;22814378;24374639;33491328;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSW7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071528 tRNA re-export from nucleus;GO:0006611 protein export from nucleus;GO:0006405 RNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P52918-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53043-1", "uniprot_id": "PPP5_YEAST", "mass": 57995.0, "length": 513, "protein_name": "Serine/threonine-protein phosphatase T", "gene_name": "PPT1", "organism": "Yeast", "refseq_name": "protein serine/threonine phosphatase", "refseq_ac": "NP_011639", "gene_names_uniprotkb": "PPT1; G6347", "gene_names_refseq": "PPT1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase T; 3.1.3.16; PPT", "protein_names_refseq": "protein serine/threonine phosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR123C); (R-SCE-8939211)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12694636;1321058;14562095;14562106;16407978;16442612;17322287;24374639;33491328;7925273;9046098;9169869", "class_list": "", "function": "Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90 (HSC82 and HSP82). Dephosphorylation positively regulates the Hsp90 chaperone machinery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUQ5", "ec_number_list": "3.1.3.16;3.1.3.43;3.1.3.48;5.2.1.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53044-1", "uniprot_id": "UFD1_YEAST", "mass": 39810.0, "length": 361, "protein_name": "Ubiquitin fusion degradation protein 1", "gene_name": "UFD1", "organism": "Yeast", "refseq_name": "polyubiquitin-binding protein UFD1", "refseq_ac": "NP_011562", "gene_names_uniprotkb": "UFD1; PIP3", "gene_names_refseq": "UFD1", "protein_names_uniprotkb": "Ubiquitin fusion degradation protein 1; Polymerase-interacting protein 3; UB fusion protein 1", "protein_names_refseq": "polyubiquitin-binding protein UFD1", "tax_id": 559292, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583); neurodegenerative disease (Disease Ontology:DOID:1289); schizophrenia (Disease Ontology:DOID:5419); cleft palate (Disease Ontology:DOID:674)", "pathway": " (sce:YGR048W); (R-SCE-8951664); (R-SCE-9755511)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "11598205;11733065;11740563;11847109;14562106;15665377;16004872;16273108;16427015;16873066;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22031224;22218487;23749301;24374639;33481703;33491328;7615550;9169869;9236779", "class_list": "", "function": "Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUI5;Q45U36", "ec_number_list": "", "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0030894 replisome;GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:1990112 RQC complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070651 nonfunctional rRNA decay;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P53044-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53045-1", "uniprot_id": "ERG25_YEAST", "mass": 36479.0, "length": 309, "protein_name": "C-4 methylsterol oxidase ERG25", "gene_name": "ERG25", "organism": "Yeast", "refseq_name": "methylsterol monooxygenase", "refseq_ac": "NP_011574", "gene_names_uniprotkb": "ERG25; FET6", "gene_names_refseq": "ERG25", "protein_names_uniprotkb": "C-4 methylsterol oxidase ERG25; 1.14.18.-; Ergosterol biosynthetic protein 25; SMO; Sterol-C4-methyl oxidase ERG25", "protein_names_refseq": "methylsterol monooxygenase", "tax_id": 559292, "disease": "chondrodysplasia punctata (Disease Ontology:DOID:2581)", "pathway": " (sce:YGR060W); (R-SCE-192105); (R-SCE-6807047)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "12119386;12880870;14557538;14562106;15716577;15995173;16273108;17322287;22106047;24374639;29773647;32679672;8552601;8663358;9169869", "class_list": "", "function": "C-4 methylsterol oxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:12880870, PubMed:29773647, PubMed:8552601). ERG25 is a catalytic component of the C-4 demethylation complex that catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols (PubMed:12880870, PubMed:8552601). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUJ5;E9P8T3;Q45U26", "ec_number_list": "1.14.18.-", "go_molecular_function": "GO:0000254 C-4 methylsterol oxidase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53045-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53064-1", "uniprot_id": "RTF1_YEAST", "mass": 65869.0, "length": 558, "protein_name": "RNA polymerase-associated protein RTF1", "gene_name": "RTF1", "organism": "Yeast", "refseq_name": "RNA polymerase-associated protein", "refseq_ac": "NP_011270", "gene_names_uniprotkb": "RTF1; CSL3; HRA458", "gene_names_refseq": "CSL3; RTF1", "protein_names_uniprotkb": "RNA polymerase-associated protein RTF1", "protein_names_refseq": "RNA polymerase-associated protein", "tax_id": 559292, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (sce:YGL244W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11884586;14562095;14562106;15643076;16246725;17287358;18407956;19779198;19795423;19823750;21126336;21177495;23749301;24374639;32597660;33481703;33491328;8750240;9169869;9234706", "class_list": "", "function": "The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. Important for TATA site selection by TBP. Directly or indirectly regulates the DNA-binding properties of SPT15, the TATA box-binding protein, and the relative activities of different TATA elements., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV91;P89115", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0006353 DNA-templated transcription termination;GO:0070911 global genome nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P53064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53068-1", "uniprot_id": "APC10_YEAST", "mass": 28777.0, "length": 250, "protein_name": "Anaphase-promoting complex subunit DOC1", "gene_name": "DOC1", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit DOC1", "refseq_ac": "NP_011274", "gene_names_uniprotkb": "DOC1; APC10; HRC283", "gene_names_refseq": "APC10; DOC1", "protein_names_uniprotkb": "Anaphase-promoting complex subunit DOC1; Destruction of cyclin B protein 1", "protein_names_refseq": "anaphase promoting complex subunit DOC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL240W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11884135;12402045;12574115;12748633;14562095;14562106;24374639;33491328;8750240;9169869;9348530", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. DOC1 is required, together with the coactivators CDH1 and CDC20, for recognition and binding of the substrates., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV95", "ec_number_list": "", "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53068-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53093-1", "uniprot_id": "YIP4_YEAST", "mass": 25995.0, "length": 235, "protein_name": "Protein YIP4", "gene_name": "YIP4", "organism": "Yeast", "refseq_name": "Yip4p", "refseq_ac": "NP_011317", "gene_names_uniprotkb": "YIP4; G1304", "gene_names_refseq": "YIP4", "protein_names_uniprotkb": "Protein YIP4; YPT-interacting protein 4", "protein_names_refseq": "Yip4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL198W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11943201;12748633;17178117;24374639;9046087;9169869", "class_list": "", "function": "May be involved in proper membrane localization of Rab GTPases., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTV5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53093-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53131-1", "uniprot_id": "PRP43_YEAST", "mass": 87562.0, "length": 767, "protein_name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43", "gene_name": "PRP43", "organism": "Yeast", "refseq_name": "DEAH-box ATP-dependent RNA helicase PRP43", "refseq_ac": "NP_011395", "gene_names_uniprotkb": "PRP43", "gene_names_refseq": "PRP43", "protein_names_uniprotkb": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43; 3.6.4.13; Helicase JA1", "protein_names_refseq": "DEAH-box ATP-dependent RNA helicase PRP43", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL120C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562106;14690591;15665377;16357217;16880513;17287358;17330950;17563356;18407956;19779198;20489023;21126336;24374639;32597660;33229814;33481703;33491328;9169869;9342317", "class_list": "", "function": "Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VU28", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005681 spliceosomal complex;GO:0071014 post-mRNA release spliceosomal complex;GO:0030686 90S preribosome", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53141-1", "uniprot_id": "MLC1_YEAST", "mass": 16444.0, "length": 149, "protein_name": "Myosin light chain 1", "gene_name": "MLC1", "organism": "Yeast", "refseq_name": "Mlc1p", "refseq_ac": "NP_011409", "gene_names_uniprotkb": "MLC1; G3080", "gene_names_refseq": "MLC1", "protein_names_uniprotkb": "Myosin light chain 1; Calmodulin-like myosin light chain MLC1; Myosin-2 light chain", "protein_names_refseq": "Mlc1p", "tax_id": 559292, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); cardiomyopathy (Disease Ontology:DOID:0050700); congenital myopathy 14 (Disease Ontology:DOID:0081346); hypertrophic cardiomyopathy 8 (Disease Ontology:DOID:0110314); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (sce:YGL106W); (R-SCE-5627123)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10873803;11082046;12351846;12456647;12554638;15210731;22106047;24374639;33481703;33491328;9046090;9169869;9700160", "class_list": "", "function": "Essential light chain for the class II conventional myosin MYO1. Also acts as light chain for the class V unconventional myosin MYO2 and for IQG1. Involved in the assembly of the contractile actomyosin ring at the bud neck during cytokinesis by recruiting IQG1 to the bud neck. Also required for chitin and MYO2-dependent secretory vesicle deposition to the center of the bud neck for septum formation. May stabilize MYO2 by binding to its IQ domains. Its major function is probably not to regulate MYO1 activity, but rather to coordinate actin ring formation and targeted membrane deposition during cytokinesis via its interactions with MYO1, IQG1 and MYO2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU40", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0031489 myosin V binding;GO:0032038 myosin II heavy chain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031982 vesicle;GO:0030427 site of polarized growth;GO:0016460 myosin II complex;GO:0000142 cellular bud neck contractile ring", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0030050 vesicle transport along actin filament;GO:0006903 vesicle targeting;GO:0032465 regulation of cytokinesis;GO:1903475 mitotic actomyosin contractile ring assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53233-1", "uniprot_id": "FMP48_YEAST", "mass": 42823.0, "length": 369, "protein_name": "Probable serine/threonine-protein kinase FMP48", "gene_name": "FMP48", "organism": "Yeast", "refseq_name": "protein kinase FMP48", "refseq_ac": "NP_011566", "gene_names_uniprotkb": "FMP48", "gene_names_refseq": "FMP48", "protein_names_uniprotkb": "Probable serine/threonine-protein kinase FMP48; 2.7.11.1; Found in mitochondrial proteome protein 48", "protein_names_refseq": "protein kinase FMP48", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR052W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;14576278;17608707;20489023;24374639;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUI7", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53233-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53617-1", "uniprot_id": "NRD1_YEAST", "mass": 63859.0, "length": 575, "protein_name": "Protein NRD1", "gene_name": "NRD1", "organism": "Yeast", "refseq_name": "Nrd1 complex RNA-binding subunit", "refseq_ac": "NP_014148", "gene_names_uniprotkb": "NRD1; N0868", "gene_names_refseq": "NRD1", "protein_names_uniprotkb": "Protein NRD1", "protein_names_refseq": "Nrd1 complex RNA-binding subunit", "tax_id": 559292, "disease": "Fliedner-Zweier syndrome (Disease Ontology:DOID:0070653)", "pathway": " (sce:YNL251C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11875433;14562106;17330950;17563356;18407956;19684113;19779198;20702584;21177495;23749301;24374639;32597660;33481703;33491328;8943355;9169873;9234673", "class_list": "", "function": "Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0U2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0001068 transcription regulatory region RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035649 Nrd1 complex", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0031124 mRNA 3'-end processing;GO:0042780 tRNA 3'-end processing;GO:0071034 CUT catabolic process;GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53617-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53632-1", "uniprot_id": "PAP2_YEAST", "mass": 66031.0, "length": 584, "protein_name": "Poly(A) RNA polymerase protein 2", "gene_name": "PAP2", "organism": "Yeast", "refseq_name": "non-canonical poly(A) polymerase PAP2", "refseq_ac": "NP_014526", "gene_names_uniprotkb": "PAP2; HRC584; O0716; TRF4", "gene_names_refseq": "PAP2; TRF4", "protein_names_uniprotkb": "Poly(A) RNA polymerase protein 2; 2.7.7.19; DNA polymerase kappa; DNA polymerase sigma; Topoisomerase 1-related protein TRF4", "protein_names_refseq": "non-canonical poly(A) polymerase PAP2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL115W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10066793;10926539;11579108;11861546;12062100;12665575;14562095;14562106;15145828;15828860;15935758;15935759;16260630;16373491;16431988;17179095;17322287;18631361;19795423;19823750;20696927;24374639;33481703;33491328;7502582;8647385;8710513;8895658;9169874", "class_list": "", "function": "Catalytic subunit of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF4 is also required for proper nuclear division in mitosis, DNA damage repair and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 27, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1V2", "ec_number_list": "2.7.7.19", "go_molecular_function": "GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0031499 TRAMP complex", "go_biological_process": "GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process;GO:0051301 cell division;GO:0006284 base-excision repair;GO:0006400 tRNA modification;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P53632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53633-1", "uniprot_id": "PRA1_YEAST", "mass": 19412.0, "length": 176, "protein_name": "Prenylated Rab acceptor 1", "gene_name": "YIP3", "organism": "Yeast", "refseq_name": "Yip3p", "refseq_ac": "NP_014354", "gene_names_uniprotkb": "YIP3; N2650; PRA1", "gene_names_refseq": "YIP3", "protein_names_uniprotkb": "Prenylated Rab acceptor 1", "protein_names_refseq": "Yip3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL044W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11785952;14562095;14562106;18407956;22814378;24374639;33481703;33491328;35563734;8740423;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1D5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53686-1", "uniprot_id": "HST2_YEAST", "mass": 39979.0, "length": 357, "protein_name": "NAD-dependent protein deacetylase HST2", "gene_name": "HST2", "organism": "Yeast", "refseq_name": "histone deacetylase HST2", "refseq_ac": "NP_015310", "gene_names_uniprotkb": "HST2; LPA2C", "gene_names_refseq": "HST2", "protein_names_uniprotkb": "NAD-dependent protein deacetylase HST2; 2.3.1.286; Homologous to SIR2 protein 2; Regulatory protein SIR2 homolog 2", "protein_names_refseq": "histone deacetylase HST2", "tax_id": 559292, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); prediabetes syndrome (Disease Ontology:DOID:11716); high grade glioma (Disease Ontology:DOID:3070); intermittent claudication (Disease Ontology:DOID:3669); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YPL015C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10811920;11106374;11226170;14502267;14562095;14562106;14604530;15150415;15274642;16520376;17110954;17289592;17322287;18407956;19795423;19823750;20726530;21725298;22814378;23749301;24374639;32597660;33187982;33481703;33491328;7498786;9169875", "class_list": "", "function": "NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Z7", "ec_number_list": "2.3.1.286", "go_molecular_function": "GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0046872 metal ion binding;GO:0070403 NAD+ binding;GO:0017136 histone deacetylase activity, NAD-dependent", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045950 negative regulation of mitotic recombination;GO:0000183 rDNA heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P53686-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53691-1", "uniprot_id": "PPID_YEAST", "mass": 42072.0, "length": 371, "protein_name": "Peptidyl-prolyl cis-trans isomerase CPR6", "gene_name": "CPR6", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase CPR6", "refseq_ac": "NP_013317", "gene_names_uniprotkb": "CPR6; L8167.24", "gene_names_refseq": "CPR6; CYP40", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase CPR6; 5.2.1.8; PPIase CPR6; Rotamase CPR6", "protein_names_refseq": "peptidylprolyl isomerase CPR6", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR216C); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6798695)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14562106;17322287;24374639;33491328;8873448;9169871", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYL7;Q6Q5K7", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.7.6;2.7.1.1;4.2.1.24;2.7.11.23;3.6.4.13;2.4.1.1;5.6.2.3;3.4.23.25;3.1.-.-;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;2.7.7.7;3.1.11.-;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;2.3.2.27;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.6.4.-;3.4.19.12;2.4.2.7;5.6.2.4;5.4.2.7;2.3.2.26;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0043022 ribosome binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53691-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53739-1", "uniprot_id": "FPK1_YEAST", "mass": 100546.0, "length": 893, "protein_name": "Flippase kinase 1", "gene_name": "FPK1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase FPK1", "refseq_ac": "NP_014445", "gene_names_uniprotkb": "FPK1; N3449", "gene_names_refseq": "FPK1", "protein_names_uniprotkb": "Flippase kinase 1; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase FPK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR047W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "11337509;14562095;14562106;15665377;17287358;17330950;17563356;18199685;18407956;19684113;19779198;19795423;19823750;19966303;20489023;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33060204;33481703;33491328;9169873", "class_list": "", "function": "Flippase activator that phosphorylates DNF1 and DNF2 and which is involved in the generation of phospholipid asymmetry in membranes by the inward translocation of phospholipids and in the retrieval pathway from early endosomes to the trans-Golgi network (TGN). Also phosphorylates the N-terminal half of YPK1. Involved in pheromone-response., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 68, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1M2", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043332 mating projection tip", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0001932 regulation of protein phosphorylation;GO:0061092 positive regulation of phospholipid translocation;GO:2000370 positive regulation of clathrin-dependent endocytosis;GO:0000749 response to pheromone triggering conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P53739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53829-1", "uniprot_id": "CAF40_YEAST", "mass": 41155.0, "length": 373, "protein_name": "Protein CAF40", "gene_name": "CAF40", "organism": "Yeast", "refseq_name": "CCR4-NOT core subunit CAF40", "refseq_ac": "NP_014111", "gene_names_uniprotkb": "CAF40; N0540", "gene_names_refseq": "CAF40", "protein_names_uniprotkb": "Protein CAF40; 40 kDa CCR4-associated factor", "protein_names_refseq": "CCR4-NOT core subunit CAF40", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL288W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11733989;14562106;24374639;9169873", "class_list": "", "function": "Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Q5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53845-1", "uniprot_id": "YIF1_YEAST", "mass": 35498.0, "length": 314, "protein_name": "Protein transport protein YIF1", "gene_name": "YIF1", "organism": "Yeast", "refseq_name": "protein transporter YIF1", "refseq_ac": "NP_014136", "gene_names_uniprotkb": "YIF1; N0820", "gene_names_refseq": "YIF1", "protein_names_uniprotkb": "Protein transport protein YIF1; YIP1-interacting factor 1", "protein_names_refseq": "protein transporter YIF1", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YNL263C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10970842;11157978;11943201;12615067;12657649;15263065;16107716;16847258;22814378;24374639;32597660;33481703;33491328;8740425;9169873", "class_list": "", "function": "Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0T0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53845-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53849-1", "uniprot_id": "GIS2_YEAST", "mass": 17103.0, "length": 153, "protein_name": "Zinc finger protein GIS2", "gene_name": "GIS2", "organism": "Yeast", "refseq_name": "mRNA-binding translational activator GIS2", "refseq_ac": "NP_014144", "gene_names_uniprotkb": "GIS2; N0852", "gene_names_refseq": "GIS2", "protein_names_uniprotkb": "Zinc finger protein GIS2", "protein_names_refseq": "mRNA-binding translational activator GIS2", "tax_id": 559292, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759)", "pathway": " (sce:YNL255C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10628841;14562095;14562106;17322287;23749301;24374639;33481703;33491328;9169873;9234673", "class_list": "", "function": "May act in the sexual differentiation pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0T8", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003727 single-stranded RNA binding;GO:0045182 translation regulator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53858-1", "uniprot_id": "BNI4_YEAST", "mass": 100590.0, "length": 892, "protein_name": "Protein BNI4", "gene_name": "BNI4", "organism": "Yeast", "refseq_name": "Bni4p", "refseq_ac": "NP_014166", "gene_names_uniprotkb": "BNI4; N1146", "gene_names_refseq": "BNI4", "protein_names_uniprotkb": "Protein BNI4", "protein_names_refseq": "Bni4p", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 70 (Disease Ontology:DOID:0112206); Alzheimer's disease (Disease Ontology:DOID:10652); essential hypertension (Disease Ontology:DOID:10825); Moyamoya disease (Disease Ontology:DOID:13099); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); coronary stenosis (Disease Ontology:DOID:4248); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364)", "pathway": " (sce:YNL233W); (R-SCE-114608)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "17287358;17330950;17563356;18407956;19458192;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;24909858;30516470;32597660;33481703;33491328;8896273;9169873;9314530", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 93, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0V9", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005940 septin ring;GO:0000131 incipient cellular bud site;GO:0005935 cellular bud neck;GO:0032174 cellular bud neck septin collar", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0000917 division septum assembly;GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P53858-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53940-1", "uniprot_id": "APJ1_YEAST", "mass": 58889.0, "length": 528, "protein_name": "J domain-containing protein APJ1", "gene_name": "APJ1", "organism": "Yeast", "refseq_name": "Apj1p", "refseq_ac": "NP_014322", "gene_names_uniprotkb": "APJ1; N2342", "gene_names_refseq": "APJ1", "protein_names_uniprotkb": "J domain-containing protein APJ1", "protein_names_refseq": "Apj1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL077W); (R-SCE-3371497)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562095;14562106;15170475;17322287;17438278;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;8701611;9169873", "class_list": "", "function": "Putative chaperone involved in protein folding. Interferes with propagation of [PSI+] prion when overproduced., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W1A2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0001671 ATPase activator activity;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0034399 nuclear periphery;GO:0042405 nuclear inclusion body", "go_biological_process": "GO:0043335 protein unfolding;GO:0016925 protein sumoylation;GO:0034605 cellular response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P53940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60010-1", "uniprot_id": "ACT_YEAST", "mass": 41690.0, "length": 375, "protein_name": "Actin", "gene_name": "ACT1", "organism": "Yeast", "refseq_name": "actin", "refseq_ac": "NP_116614", "gene_names_uniprotkb": "ACT1; ABY1; END7", "gene_names_refseq": "ABY1; ACT1; END7", "protein_names_uniprotkb": "Actin; 3.6.4.-", "protein_names_refseq": "actin", "tax_id": 559292, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); spermatogenic failure 86 (Disease Ontology:DOID:0070585); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); aortic dissection (Disease Ontology:DOID:0080685); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Baraitser-Winter syndrome 2 (Disease Ontology:DOID:0081113); congenital myopathy 2B (Disease Ontology:DOID:0081339); congenital myopathy 2C (Disease Ontology:DOID:0081340); atrial heart septal defect 5 (Disease Ontology:DOID:0110110); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); dilated cardiomyopathy 1R (Disease Ontology:DOID:0110456); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); nemaline myopathy 3 (Disease Ontology:DOID:0110927); intestinal atresia (Disease Ontology:DOID:10486); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); hand, foot and mouth disease (Disease Ontology:DOID:10881); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); male infertility (Disease Ontology:DOID:12336); dilated cardiomyopathy (Disease Ontology:DOID:12930); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); thrombocytopenia (Disease Ontology:DOID:1588); nemaline myopathy (Disease Ontology:DOID:3191); temporal lobe epilepsy (Disease Ontology:DOID:3328); bladder urothelial carcinoma (Disease Ontology:DOID:4006); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423); lymphedema (Disease Ontology:DOID:4977)", "pathway": " (sce:YFL039C); (R-SCE-114608); (R-SCE-190873); (R-SCE-196025); (R-SCE-2029482); (R-SCE-5626467); (R-SCE-5663213); (R-SCE-8980692)", "pathway_count": 8, "publication_count": 26, "publication_id_list": "10496983;11491363;12732734;15126500;18407956;1885608;1935913;19779198;21126336;21239490;22106047;22814378;23749301;24374639;24909858;28796488;32597660;33481703;33491328;6096014;6286825;6994099;7001447;7003553;7670463;8935650", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTJ1;P02579;Q9P3X6;Q9P3X7", "ec_number_list": "1.8.-.-;1.15.1.1;3.6.4.13;3.6.5.2;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;2.7.11.13;3.6.4.6;5.6.2.5;3.6.5.5;3.6.1.-;2.3.2.27;3.1.4.4;3.1.-.-;3.4.24.-;3.6.5.-;3.4.-.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0031011 Ino80 complex;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006897 endocytosis;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P60010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61830-1", "uniprot_id": "H3_YEAST", "mass": 15356.0, "length": 136, "protein_name": "Histone H3", "gene_name": "HHT1; HHT2", "organism": "Yeast", "refseq_name": "histone H3", "refseq_ac": "NP_009564", "gene_names_uniprotkb": "HHT1; HHT2; N2749; SIN2; YBR0201", "gene_names_refseq": "BUR5; HHT1; SIN2", "protein_names_uniprotkb": "Histone H3", "protein_names_refseq": "histone H3", "tax_id": 559292, "disease": "Bryant-Li-Bhoj neurodevelopmental syndrome (Disease Ontology:DOID:0051010); Bryant-Li-Bhoj neurodevelopmental syndrome 1 (Disease Ontology:DOID:0051011); Bryant-Li-Bhoj neurodevelopmental syndrome 2 (Disease Ontology:DOID:0051012); diffuse midline glioma, H3 K27-altered (Disease Ontology:DOID:0080684)", "pathway": " (sce:YBR010W); (sce:YNL031C)", "pathway_count": 2, "publication_count": 61, "publication_id_list": "10082517;10777603;10911986;10975519;11498592;11545749;11566884;11742990;11751634;11752412;11839797;12080090;12097318;12152067;12353038;12574507;12629047;12773564;12845608;12917322;14562106;15059259;15632126;15719021;15798214;15888442;15949446;16015338;16122352;16168379;16185711;16260619;16980586;17189264;17194708;17320445;17322287;19113941;19578373;20139971;20520775;22389435;23749301;24374639;27089029;27105113;28986445;29938647;32597660;32933557;33372657;33491328;33500413;35704464;6355483;7035169;7813418;782914;9169873;9391047;9606197", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP, UAF seems to stimulate basal transcription to a fully activated level., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ11;E9PAG1;P02303;P13996;Q6B1U3;Q6Q7G9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0008823 cupric reductase (NADH) activity;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0006878 intracellular copper ion homeostasis;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0009303 rRNA transcription", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "P61830-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P87108-1", "uniprot_id": "TIM10_YEAST", "mass": 10305.0, "length": 93, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM10", "gene_name": "TIM10", "organism": "Yeast", "refseq_name": "protein transporter TIM10", "refseq_ac": "NP_011869", "gene_names_uniprotkb": "TIM10; MRS11; YHR005BC", "gene_names_refseq": "MRS11; TIM10", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM10; Mitochondrial intermembrane protein MRS11", "protein_names_refseq": "protein transporter TIM10", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR005C-A); (R-SCE-1268020)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10369662;10995434;11483513;11509656;11867522;12138093;12391147;12637749;12882976;14973126;14973127;14978039;16039669;16199054;16823961;21126336;22984289;24374639;33481703;33491328;8091229;8955274;9236772;9430585;9822593;9889188", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Compared to TIM9, it may function as a substrate sensor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKU9", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0032977 membrane insertase activity;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P87108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P89105-1", "uniprot_id": "CTR9_YEAST", "mass": 124709.0, "length": 1077, "protein_name": "RNA polymerase-associated protein CTR9", "gene_name": "CTR9", "organism": "Yeast", "refseq_name": "Ctr9p", "refseq_ac": "NP_014496", "gene_names_uniprotkb": "CTR9; CDP1", "gene_names_refseq": "CDP1; CTR9", "protein_names_uniprotkb": "RNA polymerase-associated protein CTR9; Centromere-binding factor 1-dependent protein 1; Cln three-requiring protein 9", "protein_names_refseq": "Ctr9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL145C)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10219085;11058104;11884586;12242279;14562106;15531585;15643076;16246725;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;27821475;30516470;32597660;33481703;33491328;8553699;8978028;9169874", "class_list": "", "function": "The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. In complex with PAF1, required for normal CLN1 and CLN2 G1 cyclin expression in late G1. Also has a role in chromosome segregation where it appears to be involved in microtubule placement., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S4;O14409;Q07332;Q08292", "ec_number_list": "", "go_molecular_function": "GO:0045142 triplex DNA binding;GO:0000993 RNA polymerase II complex binding;GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0006360 transcription by RNA polymerase I;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P89105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00402-1", "uniprot_id": "NUM1_YEAST", "mass": 313033.0, "length": 2748, "protein_name": "Nuclear migration protein NUM1", "gene_name": "NUM1", "organism": "Yeast", "refseq_name": "Num1p", "refseq_ac": "NP_010434", "gene_names_uniprotkb": "NUM1; PAC12; YD8358.06", "gene_names_refseq": "NUM1; PAC12", "protein_names_uniprotkb": "Nuclear migration protein NUM1", "protein_names_refseq": "Num1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR150W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11121446;11266443;15665377;17287358;17330950;1745235;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;7490278;9169867", "class_list": "", "function": "Controls nuclear migration. NUM1 specifically controls the interaction of the bud neck cytoskeleton with the pre-divisional G2 nucleus. Functions in dynein-anchoring. During late anaphase forms dynein-interacting cortical microtubule capture sites at both cellular poles. This leads to dynein-dependent sliding of the microtubules in the bud., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 77, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSD2;Q03767", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0005934 cellular bud tip", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0000266 mitochondrial fission;GO:0048312 intracellular distribution of mitochondria;GO:0032065 maintenance of protein location in cell cortex;GO:0030473 nuclear migration along microtubule", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q00402-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00416-1", "uniprot_id": "SEN1_YEAST", "mass": 252497.0, "length": 2231, "protein_name": "Helicase SEN1", "gene_name": "SEN1", "organism": "Yeast", "refseq_name": "DNA/RNA helicase SEN1", "refseq_ac": "NP_013534", "gene_names_uniprotkb": "SEN1; L9576.1", "gene_names_refseq": "CIK3; NRD2; SEN1", "protein_names_uniprotkb": "Helicase SEN1; 5.6.2.3; DNA:DNA and RNA:DNA 5'-3' helicase SEN1; tRNA-splicing endonuclease positive effector", "protein_names_refseq": "DNA/RNA helicase SEN1", "tax_id": 559292, "disease": "spinocerebellar ataxia with axonal neuropathy 2 (Disease Ontology:DOID:0050755); amyotrophic lateral sclerosis type 4 (Disease Ontology:DOID:0060196)", "pathway": " (sce:YLR430W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11565036;14562095;14562106;15121901;1569945;17157256;21126336;21177495;23749301;24374639;26198638;32597660;33481703;33491328;35037029;36864660;8544822;8943355;9169871;9365256;9819377", "class_list": "", "function": "ATP-dependent 5'-3' DNA:DNA and DNA:RNA helicase (PubMed:26198638). In vitro preferentially unwinds DNA:DNA substrates over RNA:DNA substrates (PubMed:36864660). Required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ65;E9P9Z4;Q06448", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005657 replication fork;GO:0035649 Nrd1 complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008033 tRNA processing;GO:0006974 DNA damage response;GO:0045454 cell redox homeostasis;GO:0006353 DNA-templated transcription termination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q00416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00684-1", "uniprot_id": "CDC14_YEAST", "mass": 61907.0, "length": 551, "protein_name": "Tyrosine-protein phosphatase CDC14", "gene_name": "CDC14", "organism": "Yeast", "refseq_name": "phosphoprotein phosphatase CDC14", "refseq_ac": "NP_116684", "gene_names_uniprotkb": "CDC14; OAF3", "gene_names_refseq": "CDC14; OAF3", "protein_names_uniprotkb": "Tyrosine-protein phosphatase CDC14; 3.1.3.48", "protein_names_refseq": "phosphoprotein phosphatase CDC14", "tax_id": 559292, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal recessive nonsyndromic deafness 32 (Disease Ontology:DOID:0110491); vascular disease (Disease Ontology:DOID:178); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (sce:YFR028C); (R-SCE-176407); (R-SCE-5687128)", "pathway_count": 3, "publication_count": 63, "publication_id_list": "11511359;12737806;14562106;14993267;15004526;15128740;15137939;15190202;15273393;15917648;1597462;17116692;17330950;17563356;18235228;18287090;18407956;18595708;18794331;18927509;19158678;19221193;19339280;19684113;19779198;19795423;19823750;20489023;20619650;20660629;20923974;20980394;21098112;21126336;21127052;21177495;21690308;21690311;21725298;21784165;22031224;22072794;22078879;22117071;22218487;22363215;22454527;22872148;23749301;24039885;24374639;25049391;30516470;31722221;32597660;33481703;33491328;7021319;7670463;8668128;8686381;9295359;9885559", "class_list": "", "function": "Protein phosphatase which antagonizes mitotic cyclin-dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle disassembly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery. Inhibits transcription of ribosomal genes (rDNA) during anaphase and controls segregation of nucleolus by facilitating condensin targeting to rDNA chromatin in anaphase. Dephosphorylates SIC1, a CDC28 inhibitor, and SWI5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, CDH1. Dephosphorylates the microtubule bundling factor ASE1 which is required to define a centered and focused mitotic spindle midzone that can drive continuous spindle elongation. Dephosphorylates the anaphase-promoting complex inhibitor ACM1, leading to its degradation. Facilitates INN1-CYK3 complex formation which promotes cytokinesis through the dephosphorylation of CDC28-phosphosphorylated INN1. Also reverts the inhibitory CDC28 phosphorylation of CHS2 for endoplasmic reticulum export, ensuring that septum formation is contingent upon chromosome separation and exit from mitosis. Additional substrates for CDC14 are the formins BNI1 and BNR1, as well as CDC6, DBP2, DSN1, INCENP, KAR9, MCM3, ORC2, ORC6, SLD2, and SWI6. Activity is inhibited by interaction with NET1 which sequesters it to the nucleolus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTQ8;Q05180;Q05673", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.2;2.7.11.24", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0072686 mitotic spindle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0010508 positive regulation of autophagy;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "Q00684-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00772-1", "uniprot_id": "SLT2_YEAST", "mass": 55636.0, "length": 484, "protein_name": "Mitogen-activated protein kinase SLT2/MPK1", "gene_name": "SLT2", "organism": "Yeast", "refseq_name": "mitogen-activated serine/threonine-protein kinase SLT2", "refseq_ac": "NP_011895", "gene_names_uniprotkb": "SLT2; MPK1", "gene_names_refseq": "BYC2; LYT2; MPK1; SLK2; SLT2", "protein_names_uniprotkb": "Mitogen-activated protein kinase SLT2/MPK1; 2.7.11.24; MAP kinase MPK1", "protein_names_refseq": "mitogen-activated serine/threonine-protein kinase SLT2", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (sce:YHR030C); (R-SCE-198753); (R-SCE-198765); (R-SCE-202670); (R-SCE-2559582); (R-SCE-4086398); (R-SCE-5687128); (R-SCE-881907)", "pathway_count": 8, "publication_count": 26, "publication_id_list": "11875433;12361575;12823808;14562106;16977319;17330950;1779770;18407956;19564916;19779198;19805511;20385774;20489023;20702584;21126336;22031291;23749301;24374639;26728856;33481703;33491328;33498635;8091229;8276900;8386319;9111331", "class_list": "", "function": "Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the SLT2/MPK1 kinase which itself then phosphorylates and activates the transcription factor RLM1. Directly phosphorylates BCY1 upon TOR complex 1 (TORC1) inhibition., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKX7", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.16;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.1.3.48;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005934 cellular bud tip", "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0036498 IRE1-mediated unfolded protein response;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0010447 response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q00772-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00816-1", "uniprot_id": "REG1_YEAST", "mass": 112616.0, "length": 1014, "protein_name": "Resistance to glucose repression protein 1", "gene_name": "REG1", "organism": "Yeast", "refseq_name": "protein phosphatase regulator REG1", "refseq_ac": "NP_010311", "gene_names_uniprotkb": "REG1; HEX2; PZF240; SPP43; SRN1; YD9813.06C", "gene_names_refseq": "HEX2; PZF240; REG1; SPP43; SRN1", "protein_names_uniprotkb": "Resistance to glucose repression protein 1; Protein HEX2; Second-site suppressor of the rna1-1 mutation 1", "protein_names_refseq": "protein phosphatase regulator REG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR028C)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "11875433;14562106;15665377;1588964;17287358;17330950;17563356;18407956;1889400;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;21216941;22218487;22814378;23749301;24374639;28270554;30516470;32597660;33481703;33491328;8846786;8896275;9169867", "class_list": "", "function": "Involved in RNA processing and negative regulation of glucose repression. Regulates the level of two antigens, P43 and P70. Binds to protein phosphatase type 1. Functions with REG2 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 74, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS13", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005773 vacuole", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0006986 response to unfolded protein;GO:0007039 protein catabolic process in the vacuole;GO:1904547 regulation of cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q00816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01159-1", "uniprot_id": "MCE1_YEAST", "mass": 52764.0, "length": 459, "protein_name": "mRNA-capping enzyme subunit alpha", "gene_name": "CEG1", "organism": "Yeast", "refseq_name": "mRNA guanylyltransferase", "refseq_ac": "NP_011385", "gene_names_uniprotkb": "CEG1; G2853", "gene_names_refseq": "CEG1", "protein_names_uniprotkb": "mRNA-capping enzyme subunit alpha; 2.7.7.50; GTP--RNA guanylyltransferase; GTase; mRNA guanylyltransferase", "protein_names_refseq": "mRNA guanylyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL130W); (R-SCE-72086); (R-SCE-77075)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "1315757;14562106;21126336;22814378;23749301;24374639;3029058;33481703;33491328;6094533;6389537;7500935;7991582;8022828;8686378;9169869", "class_list": "", "function": "Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 45, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU18;Q9URD1", "ec_number_list": "2.7.7.6;2.7.11.23;5.6.2.3;2.1.1.56;5.6.2.4;2.7.7.50", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004484 mRNA guanylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031533 mRNA capping enzyme complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q01159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01560-1", "uniprot_id": "NOP3_YEAST", "mass": 45407.0, "length": 414, "protein_name": "Serine/arginine (SR)-type shuttling mRNA binding protein NPL3", "gene_name": "NPL3", "organism": "Yeast", "refseq_name": "mRNA-binding protein NPL3", "refseq_ac": "NP_010720", "gene_names_uniprotkb": "NPL3; D9461.19; MTR13; MTS1; NAB1; NOP3", "gene_names_refseq": "MTR13; MTS1; NAB1; NOP3; NPL3", "protein_names_uniprotkb": "Serine/arginine (SR)-type shuttling mRNA binding protein NPL3; Mitochondrial targeting suppressor 1 protein; Nuclear polyadenylated RNA-binding protein 1; Nuclear protein localization protein 3; Polyadenylate-binding protein NPL3", "protein_names_refseq": "mRNA-binding protein NPL3", "tax_id": 559292, "disease": "spermatogenic failure 3 (Disease Ontology:DOID:0070168); neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities (Disease Ontology:DOID:0070513); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); lung cancer (Disease Ontology:DOID:1324); Down syndrome (Disease Ontology:DOID:14250); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); skin cancer (Disease Ontology:DOID:4159); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); myeloid leukemia (Disease Ontology:DOID:8692); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YDR432W)", "pathway_count": 1, "publication_count": 46, "publication_id_list": "10611239;10952997;11233987;11875433;1392078;1429834;14562095;14562106;14676199;14759366;15145958;15542855;15665377;17239901;17330950;17563356;17936301;18022637;18391019;18407956;18818768;19061647;19779198;20190278;20702584;21126336;21177495;22218487;23209445;23749301;24374639;26046779;26081071;26777405;31399582;31756331;32597660;33481703;33491328;33577675;33856219;7962083;8224861;8675010;9169867;9499403", "class_list": "", "function": "Involved in mRNA processing and export (PubMed:1429834, PubMed:15542855, PubMed:19061647, PubMed:8675010). Required for efficient splicing of a large set of pre-mRNAs by efficient co-transcriptional recruitment of the splicing machinery (PubMed:19061647, PubMed:23209445). Remains associated with the mRNP during early steps of translation elongation (PubMed:15542855)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT60", "ec_number_list": "", "go_molecular_function": "GO:0061752 telomeric repeat-containing RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0003691 double-stranded telomeric DNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006415 translational termination;GO:0042254 ribosome biogenesis;GO:0017148 negative regulation of translation;GO:0000398 mRNA splicing, via spliceosome;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q01560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01590-1", "uniprot_id": "SED5_YEAST", "mass": 38807.0, "length": 340, "protein_name": "Integral membrane protein SED5", "gene_name": "SED5", "organism": "Yeast", "refseq_name": "t-SNARE syntaxin", "refseq_ac": "NP_013126", "gene_names_uniprotkb": "SED5", "gene_names_refseq": "SED5", "protein_names_uniprotkb": "Integral membrane protein SED5", "protein_names_refseq": "t-SNARE syntaxin", "tax_id": 559292, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571)", "pathway": " (sce:YLR026C); (R-SCE-204005); (R-SCE-5694530); (R-SCE-6807878); (R-SCE-6811438); (R-SCE-9013106); (R-SCE-9609523)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "12426383;12941276;1400588;14562106;16093353;21126336;21987636;24374639;9169871;9755865", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY28", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006906 vesicle fusion;GO:0048280 vesicle fusion with Golgi apparatus;GO:0090083 regulation of inclusion body assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q01590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01852-1", "uniprot_id": "TIM44_YEAST", "mass": 48854.0, "length": 431, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "TIM44", "organism": "Yeast", "refseq_name": "protein translocase subunit TIM44", "refseq_ac": "NP_012242", "gene_names_uniprotkb": "TIM44; ISP45; MIM44; MPI1", "gene_names_refseq": "ISP45; MIM44; MPI1; TIM44", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM44; ISP45; Inner membrane import site protein 45; Membrane import machinery protein MIM44; Mitochondrial protein import protein 1", "protein_names_refseq": "protein translocase subunit TIM44", "tax_id": 559292, "disease": "proliferative diabetic retinopathy (Disease Ontology:DOID:13207); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (sce:YIL022W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1396562;16107694;16647716;18426906;24374639;26714107;33481703;33491328;8344245;9169870", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVQ7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q01852-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01939-1", "uniprot_id": "PRS8_YEAST", "mass": 45272.0, "length": 405, "protein_name": "26S proteasome regulatory subunit 8 homolog", "gene_name": "RPT6", "organism": "Yeast", "refseq_name": "proteasome regulatory particle base subunit RPT6", "refseq_ac": "NP_011467", "gene_names_uniprotkb": "RPT6; CIM3; CRL3; SUG1; TBPY; TBY1", "gene_names_refseq": "CIM3; CRL3; RPT6; SCB68; SUG1", "protein_names_uniprotkb": "26S proteasome regulatory subunit 8 homolog; Protein CIM3; Protein SUG1; Tat-binding protein TBY1", "protein_names_refseq": "proteasome regulatory particle base subunit RPT6", "tax_id": 559292, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); Alzheimer's disease (Disease Ontology:DOID:10652); cancer (Disease Ontology:DOID:162); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myopathy (Disease Ontology:DOID:423)", "pathway": " (sce:YGL048C); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-9907900)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10688918;12504901;1388730;14562106;1614516;16284124;17322287;22927375;24374639;25042801;28662109;30181345;33481703;33491328;8628401;9169869;9234674", "class_list": "", "function": "The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU92", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus", "go_biological_process": "GO:0070651 nonfunctional rRNA decay;GO:0006338 chromatin remodeling;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070682 proteasome regulatory particle assembly;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q01939-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02326-1", "uniprot_id": "RL6A_YEAST", "mass": 19962.0, "length": 176, "protein_name": "Large ribosomal subunit protein eL6A", "gene_name": "RPL6A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL6 RPL6A", "refseq_ac": "NP_013638", "gene_names_uniprotkb": "RPL6A; RPL17A; YL16A", "gene_names_refseq": "RPL6A; YL16A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL6A; 60S ribosomal protein L6-A; L17; RP18; YL16", "protein_names_refseq": "60S ribosomal protein eL6 RPL6A", "tax_id": 559292, "disease": "", "pathway": " (sce:YML073C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 21, "publication_id_list": "10601260;1390890;14562095;14562106;15665377;17563356;18407956;19779198;20702584;21109664;21126336;21177495;22096102;22106047;23749301;24374639;24524803;32597660;33491328;9169872;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZA0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q02326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02516-1", "uniprot_id": "HAP5_YEAST", "mass": 27676.0, "length": 242, "protein_name": "Transcriptional activator HAP5", "gene_name": "HAP5", "organism": "Yeast", "refseq_name": "Hap5p", "refseq_ac": "NP_015003", "gene_names_uniprotkb": "HAP5", "gene_names_refseq": "HAP5", "protein_names_uniprotkb": "Transcriptional activator HAP5", "protein_names_refseq": "Hap5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR358W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11390369;14562106;16278450;18407956;19779198;23749301;24374639;30516470;33481703;33491328;7828851;9169874;9372932", "class_list": "", "function": "Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP5 is essential for DNA-binding activity. It may be the linchpin that binds to the subunit association domains (SAD) of HAP2 and HAP3 to bring these proteins together., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W353;Q08827", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0006109 regulation of carbohydrate metabolic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02888-1", "uniprot_id": "INA17_YEAST", "mass": 21842.0, "length": 182, "protein_name": "Inner membrane assembly complex subunit 17", "gene_name": "INA17", "organism": "Yeast", "refseq_name": "Ina17p", "refseq_ac": "NP_015226", "gene_names_uniprotkb": "INA17; AIM43; FMP14", "gene_names_refseq": "AIM43; FMP14; INA17", "protein_names_uniprotkb": "Inner membrane assembly complex subunit 17; Altered inheritance of mitochondria protein 43; Found in mitochondrial proteome protein 14; INA complex 17 kDa subunit", "protein_names_refseq": "Ina17p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL099C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14576278;19300474;24374639;24942160;33229814;9169875", "class_list": "", "function": "Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W3R7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990524 INA complex", "go_biological_process": "GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q02888-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03071-1", "uniprot_id": "ELOC_YEAST", "mass": 11328.0, "length": 99, "protein_name": "Elongin-C", "gene_name": "ELC1", "organism": "Yeast", "refseq_name": "elongin C", "refseq_ac": "NP_015279", "gene_names_uniprotkb": "ELC1", "gene_names_refseq": "ELC1", "protein_names_uniprotkb": "Elongin-C", "protein_names_refseq": "elongin C", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL046C); (R-SCE-6796648); (R-SCE-983168)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10430890;10753924;10760578;10998253;11545595;11864988;14562095;14562106;15665377;17322287;19795423;19823750;19920177;22814378;23993092;24374639;33481703;33491328;9169875;9425272", "class_list": "", "function": "As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair (PubMed:19920177). Prevents degradation of interacting proteins like PCL6 by the proteasome (PubMed:11864988)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3W8;O13292", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0070449 elongin complex;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0000113 nucleotide-excision repair factor 4 complex", "go_biological_process": "GO:0009411 response to UV;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0034644 cellular response to UV;GO:0070911 global genome nucleotide-excision repair;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q03071-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03195-1", "uniprot_id": "RLI1_YEAST", "mass": 68340.0, "length": 608, "protein_name": "Translation initiation factor RLI1", "gene_name": "RLI1", "organism": "Yeast", "refseq_name": "Fe-S cluster-binding ribosome biosynthesis protein", "refseq_ac": "NP_010376", "gene_names_uniprotkb": "RLI1", "gene_names_refseq": "RLI1", "protein_names_uniprotkb": "Translation initiation factor RLI1; ATP-binding cassette sub-family E member RLI1; RNase L inhibitor", "protein_names_refseq": "Fe-S cluster-binding ribosome biosynthesis protein", "tax_id": 559292, "disease": "breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YDR091C); (R-SCE-9954714)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14562095;14562106;15277527;15660134;15660135;17322287;18407956;19779198;21126336;23318452;23749301;24374639;26182403;32597660;33229814;33481703;33491328;9169867", "class_list": "", "function": "Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VS78", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043024 ribosomal small subunit binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0006415 translational termination;GO:0042273 ribosomal large subunit biogenesis;GO:0000054 ribosomal subunit export from nucleus;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q03195-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03407-1", "uniprot_id": "PKH1_YEAST", "mass": 86253.0, "length": 766, "protein_name": "Serine/threonine-protein kinase PKH1", "gene_name": "PKH1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase PKH1", "refseq_ac": "NP_010778", "gene_names_uniprotkb": "PKH1", "gene_names_refseq": "PKH1", "protein_names_uniprotkb": "Serine/threonine-protein kinase PKH1; 2.7.11.1; 3-phosphoinositide-dependent protein kinase 1", "protein_names_refseq": "serine/threonine protein kinase PKH1", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YDR490C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10074427;15665377;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;23749301;24374639;30516470;31208443;32597660;33481703;33491328;9169867", "class_list": "", "function": "Activates YPK1 by phosphorylating of a threonine residue., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTB3", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0006897 endocytosis;GO:0035556 intracellular signal transduction;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway;GO:0000196 cell integrity MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q03407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04006-1", "uniprot_id": "UPS3_YEAST", "mass": 20921.0, "length": 179, "protein_name": "Protein UPS3, mitochondrial", "gene_name": "UPS3", "organism": "Yeast", "refseq_name": "Ups3p", "refseq_ac": "NP_010471", "gene_names_uniprotkb": "UPS3; GEP2", "gene_names_refseq": "GEP2; UPS3", "protein_names_uniprotkb": "Protein UPS3, mitochondrial; Genetic interactor of prohibitins protein 2; Unprocessed MGM1 protein 3", "protein_names_refseq": "Ups3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR185C); (R-SCE-6803204)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562095;14562106;17322287;19221197;19506038;20622808;24374639;9169867", "class_list": "", "function": "Required for mitochondrial morphology. With UPS1 and UPS2, controls phospholipid metabolism in the mitochondrial intermembrane space., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSG9", "ec_number_list": "", "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015914 phospholipid transport;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04006-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04067-1", "uniprot_id": "EIF3G_YEAST", "mass": 30501.0, "length": 274, "protein_name": "Eukaryotic translation initiation factor 3 subunit G", "gene_name": "TIF35", "organism": "Yeast", "refseq_name": "translation initiation factor eIF3 core subunit g", "refseq_ac": "NP_010717", "gene_names_uniprotkb": "TIF35; D9461.16", "gene_names_refseq": "TIF35", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit G; Eukaryotic translation initiation factor 3 RNA-binding subunit; Translation initiation factor eIF3 p33 subunit; eIF-3 RNA-binding subunit; eIF3 p33; eIF3g", "protein_names_refseq": "translation initiation factor eIF3 core subunit g", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR429C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10085088;14562095;16581774;17563356;18407956;18599441;19779198;21126336;22218487;22814378;23749301;24374639;30516470;32027465;32597660;33229814;33481703;33491328;9169867;9671501", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Binds to the 18S rRNA but non-specifically (PubMed:10085088)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VT58", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0002188 translation reinitiation;GO:0006415 translational termination;GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q04067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04087-1", "uniprot_id": "LRS4_YEAST", "mass": 39354.0, "length": 347, "protein_name": "Monopolin complex subunit LRS4", "gene_name": "LRS4", "organism": "Yeast", "refseq_name": "Lrs4p", "refseq_ac": "NP_010727", "gene_names_uniprotkb": "LRS4; D9461.25", "gene_names_refseq": "LRS4", "protein_names_uniprotkb": "Monopolin complex subunit LRS4; Loss of rDNA silencing protein 4", "protein_names_refseq": "Lrs4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR439W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10082585;12586695;12689592;12717442;14562095;14562106;15620644;15620645;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;32597660;33481703;33491328;33502312;9169867", "class_list": "", "function": "Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT66", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0033551 monopolin complex", "go_biological_process": "GO:0051455 spindle attachment to meiosis I kinetochore;GO:0045143 homologous chromosome segregation;GO:0000183 rDNA heterochromatin formation;GO:0045132 meiotic chromosome segregation;GO:1990414 replication-born double-strand break repair via sister chromatid exchange", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q04087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04226-1", "uniprot_id": "TAF11_YEAST", "mass": 40624.0, "length": 346, "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "TAF11", "organism": "Yeast", "refseq_name": "TATA-binding protein-associated factor TAF11", "refseq_ac": "NP_013697", "gene_names_uniprotkb": "TAF11; TAF40; YM9571.03C", "gene_names_refseq": "TAF11; TAF40", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 11; P40; TAFII-40; TAFII40; TBP-associated factor 11; TBP-associated factor 40 kDa", "protein_names_refseq": "TATA-binding protein-associated factor TAF11", "tax_id": 559292, "disease": "", "pathway": " (sce:YML015C); (R-SCE-674695); (R-SCE-6807505); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10788514;11295558;12093743;12138208;12516863;17322287;17563356;19779198;21126336;23749301;24374639;32597660;33491328;9083082;9169872;9695952", "class_list": "", "function": "Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZF9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q04226-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04437-1", "uniprot_id": "KU80_YEAST", "mass": 71241.0, "length": 629, "protein_name": "ATP-dependent DNA helicase II subunit 2", "gene_name": "YKU80", "organism": "Yeast", "refseq_name": "ATP-dependent DNA helicase YKU80", "refseq_ac": "NP_013824", "gene_names_uniprotkb": "YKU80; HDF2; YM9718.05C", "gene_names_refseq": "HDF2; YKU80", "protein_names_uniprotkb": "ATP-dependent DNA helicase II subunit 2; 3.6.4.12; ATP-dependent DNA helicase II subunit Ku80; High affinity DNA-binding factor subunit 2; Yeast Ku80", "protein_names_refseq": "ATP-dependent DNA helicase YKU80", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); squamous cell carcinoma (Disease Ontology:DOID:1749); rectum cancer (Disease Ontology:DOID:1993); basal cell carcinoma (Disease Ontology:DOID:2513); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (sce:YMR106C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10675560;11046137;12138180;12975323;14551211;14562106;14585978;16166630;16951060;24374639;33491328;8509423;8910371;8972848;9169872;9563951;9635192;9635193;9663392;9914366", "class_list": "", "function": "Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZS9;Q0P737;Q0P738;Q0P741;Q0P749", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;5.6.2.3;3.6.4.10;5.3.1.9;5.1.3.-;3.6.-.-;5.6.2.4;5.2.1.8;1.11.1.6;3.5.4.6;3.6.4.-;2.7.1.11;5.6.1.4;2.7.1.2;1.1.1.42;3.6.4.12;3.4.25.1;3.6.4.6;5.6.2.5;3.6.5.-;2.7.11.24;3.6.1.-;2.3.2.27;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;3.1.-.-;3.4.24.-;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.4.2.1;2.7.1.59;3.5.4.5;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0003684 damaged DNA binding;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0000781 chromosome, telomeric region;GO:0043564 Ku70:Ku80 complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006325 chromatin organization;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q04437-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04439-1", "uniprot_id": "MYO5_YEAST", "mass": 136899.0, "length": 1219, "protein_name": "Myosin-5", "gene_name": "MYO5", "organism": "Yeast", "refseq_name": "myosin 5", "refseq_ac": "NP_013827", "gene_names_uniprotkb": "MYO5; YM9718.08", "gene_names_refseq": "MYO5", "protein_names_uniprotkb": "Myosin-5; Actin-dependent myosin-I MYO5; Class I unconventional myosin MYO5; Type I myosin MYO5", "protein_names_refseq": "myosin 5", "tax_id": 559292, "disease": "focal segmental glomerulosclerosis 6 (Disease Ontology:DOID:0111131)", "pathway": " (sce:YMR109W)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10648568;10648569;10944111;11875433;11901111;12391157;12725728;12808026;14562106;15665377;16478726;17287358;17330950;17522383;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;23749301;24374639;24909858;30516470;32597660;33481703;33491328;34965436;8614799;8682864;9169872;9628892", "class_list": "", "function": "One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZT2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0071944 cell periphery", "go_biological_process": "GO:0006897 endocytosis;GO:0006970 response to osmotic stress;GO:0007015 actin filament organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q04439-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04638-1", "uniprot_id": "ITT1_YEAST", "mass": 54096.0, "length": 464, "protein_name": "E3 ubiquitin-protein ligase ITT1", "gene_name": "ITT1", "organism": "Yeast", "refseq_name": "RBR-type E3 ubiquitin transferase", "refseq_ac": "NP_013643", "gene_names_uniprotkb": "ITT1", "gene_names_refseq": "ITT1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ITT1; 2.3.2.31", "protein_names_refseq": "RBR-type E3 ubiquitin transferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YML068W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11570975;14562106;24374639;33491328;37951215;9169872", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in translation quality control (PubMed:11570975, PubMed:37951215). Involved in the rescue of stalled ribosomes by promoting ubiquitination and degradation of proteins on stalled ribosomes (PubMed:37951215). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their degradation (PubMed:37951215). Interacts with the translation termination factors eRF1 (SUP45) and eRF3 (SUP35); overexpression decreases the efficiency of translation termination (PubMed:11570975)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZA5", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006449 regulation of translational termination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0085020 protein K6-linked ubiquitination;GO:0160127 protein-RNA covalent cross-linking repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04638-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04739-1", "uniprot_id": "GAL83_YEAST", "mass": 46648.0, "length": 417, "protein_name": "SNF1 protein kinase subunit beta-3", "gene_name": "GAL83", "organism": "Yeast", "refseq_name": "Gal83p", "refseq_ac": "NP_010944", "gene_names_uniprotkb": "GAL83; SPM1", "gene_names_refseq": "GAL83; SPM1", "protein_names_uniprotkb": "SNF1 protein kinase subunit beta-3; Glucose repression protein GAL83; Protein SPM1", "protein_names_refseq": "Gal83p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER027C); (R-SCE-1632852); (R-SCE-163680); (R-SCE-200425); (R-SCE-380972)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10990457;11331606;12393914;14562095;14562106;17287358;17322287;18407956;18851946;19779198;19795423;19823750;19897735;20489023;22218487;23749301;24374639;30516470;33481703;33491328;7813428;8293971;9121458;9169868", "class_list": "", "function": "Beta subunit of the SNF1 kinase complex, which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the SNF1 kinase complex. Promotes the relocalization of the SNF1 kinase complex to the nucleus upon shift to nonfermentable carbon sources., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS6", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0043254 regulation of protein-containing complex assembly;GO:0001403 invasive growth in response to glucose limitation;GO:0030447 filamentous growth", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q04739-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04935-1", "uniprot_id": "COX20_YEAST", "mass": 23758.0, "length": 205, "protein_name": "Cytochrome c oxidase assembly protein COX20, mitochondrial", "gene_name": "COX20", "organism": "Yeast", "refseq_name": "Cox20p", "refseq_ac": "NP_010517", "gene_names_uniprotkb": "COX20; YD9934.15c", "gene_names_refseq": "COX20", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX20, mitochondrial", "protein_names_refseq": "Cox20p", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 11 (Disease Ontology:DOID:0070497)", "pathway": " (sce:YDR231C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10671482;11381092;14562095;14576278;17322287;19779198;19795423;19823750;21126336;23749301;24374639;33481703;33491328;39753782;8885406;9169867", "class_list": "", "function": "Involved in the assembly of the cytochrome oxidase complex. Required for the maturation and subsequent assembly of the mitochondrially encoded COX2, the precursor of subunit 2 of cytochrome oxidase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSL2", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0043069 negative regulation of programmed cell death;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q04935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05029-1", "uniprot_id": "BCH1_YEAST", "mass": 82049.0, "length": 724, "protein_name": "Protein BCH1", "gene_name": "BCH1", "organism": "Yeast", "refseq_name": "exomer complex subunit", "refseq_ac": "NP_013964", "gene_names_uniprotkb": "BCH1; YM9959.19", "gene_names_refseq": "BCH1", "protein_names_uniprotkb": "Protein BCH1; BUD7 and CHS6 homolog 1", "protein_names_refseq": "exomer complex subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR237W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;16498409;16855022;17000877;18407956;19795423;19823750;21126336;24374639;33491328;9169872", "class_list": "", "function": "Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W063", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0034044 exomer complex", "go_biological_process": "GO:0015031 protein transport;GO:0006893 Golgi to plasma membrane transport;GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05029-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05040-1", "uniprot_id": "FAR8_YEAST", "mass": 59301.0, "length": 523, "protein_name": "Factor arrest protein 8", "gene_name": "FAR8", "organism": "Yeast", "refseq_name": "Far8p", "refseq_ac": "NP_013742", "gene_names_uniprotkb": "FAR8; YM9973.02C", "gene_names_refseq": "FAR8", "protein_names_uniprotkb": "Factor arrest protein 8", "protein_names_refseq": "Far8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR029C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12588993;14562095;14562106;17330950;17563356;18407956;19684113;19779198;19795423;19823750;21126336;23749301;24374639;31208443;32597660;33481703;33491328;34965436;9169872", "class_list": "", "function": "Participates in the control of the reentry into the cell cycle following pheromone treatment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZK3", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0009966 regulation of signal transduction;GO:0071444 cellular response to pheromone;GO:0000321 re-entry into mitotic cell cycle after pheromone arrest;GO:1903939 regulation of TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q05040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05776-1", "uniprot_id": "UPS1_YEAST", "mass": 20108.0, "length": 175, "protein_name": "Protein UPS1, mitochondrial", "gene_name": "UPS1", "organism": "Yeast", "refseq_name": "Ups1p", "refseq_ac": "NP_013294", "gene_names_uniprotkb": "UPS1", "gene_names_refseq": "UPS1", "protein_names_uniprotkb": "Protein UPS1, mitochondrial; Unprocessed MGM1 protein 1", "protein_names_refseq": "Ups1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR193C); (R-SCE-6803204)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562095;14562106;16754953;19221197;19506038;20622808;20657548;24374639;26071601;26071602;26235513;9169871", "class_list": "", "function": "Required for maintenance of normal mitochondrial morphology (PubMed:16754953, PubMed:26071601). Required for PCP1-dependent processing of MGM1 (PubMed:16754953). The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071601, PubMed:26071602, PubMed:26235513). Phosphatidic acid release requires dissociation of the UPS1:MDM35 complex (PubMed:26235513). Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602). With UPS2, controls the level of cardiolipin in mitochondria (PubMed:19506038). Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 23, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYJ6", "ec_number_list": "", "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015914 phospholipid transport;GO:2001247 positive regulation of phosphatidylcholine biosynthetic process;GO:0032048 cardiolipin metabolic process;GO:0120010 intermembrane phospholipid transfer", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05787-1", "uniprot_id": "HRD3_YEAST", "mass": 95481.0, "length": 833, "protein_name": "ERAD-associated E3 ubiquitin-protein ligase component HRD3", "gene_name": "HRD3", "organism": "Yeast", "refseq_name": "ubiquitin ligase complex subunit HRD3", "refseq_ac": "NP_013308", "gene_names_uniprotkb": "HRD3", "gene_names_refseq": "HRD3", "protein_names_uniprotkb": "ERAD-associated E3 ubiquitin-protein ligase component HRD3; HMG-CoA reductase degradation protein 3", "protein_names_refseq": "ubiquitin ligase complex subunit HRD3", "tax_id": 559292, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (sce:YLR207W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10218484;10547371;10793145;11018054;11390656;16619026;16845381;16873065;16873066;22262864;24374639;28682307;32327568;8970163;9169871", "class_list": "", "function": "Component of the endoplasmic reticulum quality control (ERQC) system involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M. Stabilizes the HRD1 ubiquitin-protein ligase. Also functions in recruiting misfolded protein substrates in conjunction with YOS9., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex;GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex;GO:0034099 luminal surveillance complex", "go_biological_process": "GO:0036503 ERAD pathway;GO:0030970 retrograde protein transport, ER to cytosol;GO:1905524 negative regulation of protein autoubiquitination;GO:0002235 detection of unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q05787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05911-1", "uniprot_id": "PUR8_YEAST", "mass": 54510.0, "length": 482, "protein_name": "Adenylosuccinate lyase", "gene_name": "ADE13", "organism": "Yeast", "refseq_name": "adenylosuccinase ADE13", "refseq_ac": "NP_013463", "gene_names_uniprotkb": "ADE13; L8039.12", "gene_names_refseq": "ADE13; BRA1; BRA8", "protein_names_uniprotkb": "Adenylosuccinate lyase; 4.3.2.2; ASL; ASase; Adenylosuccinase", "protein_names_refseq": "adenylosuccinase ADE13", "tax_id": 559292, "disease": "adenylosuccinase lyase deficiency (Disease Ontology:DOID:0050762); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YLR359W); (R-SCE-73817)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12872131;18407956;19779198;21126336;22814378;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYZ6", "ec_number_list": "4.3.2.2", "go_molecular_function": "GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q05911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05931-1", "uniprot_id": "HSP7Q_YEAST", "mass": 72365.0, "length": 657, "protein_name": "Iron-sulfur cluster biogenesis chaperone, mitochondrial", "gene_name": "SSQ1", "organism": "Yeast", "refseq_name": "Hsp70 family ATPase SSQ1", "refseq_ac": "NP_013473", "gene_names_uniprotkb": "SSQ1; SSC2", "gene_names_refseq": "SSC2; SSH1; SSQ1", "protein_names_uniprotkb": "Iron-sulfur cluster biogenesis chaperone, mitochondrial; 3.6.4.10; Heat shock protein SSQ1, mitochondrial; Stress-seventy subfamily Q protein 1; mtHSP70 homolog", "protein_names_refseq": "Hsp70 family ATPase SSQ1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR369W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10779357;11273703;12756240;14562095;14562106;14576278;15123690;15958384;16431909;17287358;23615440;24374639;26545917;31040179;9169871;9660806", "class_list": "", "function": "Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria (PubMed:10779357, PubMed:11273703, PubMed:12756240, PubMed:15123690, PubMed:15958384, PubMed:16431909, PubMed:31040179, PubMed:9660806). Assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins ISU1/ISU2 to GRX5 (PubMed:11273703, PubMed:12756240, PubMed:15123690, PubMed:15958384, PubMed:16431909, PubMed:23615440, PubMed:26545917, PubMed:31040179)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ06", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0042026 protein refolding;GO:0044571 [2Fe-2S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q05931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06103-1", "uniprot_id": "RPN7_YEAST", "mass": 48959.0, "length": 429, "protein_name": "26S proteasome regulatory subunit RPN7", "gene_name": "RPN7", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN7", "refseq_ac": "NP_015433", "gene_names_uniprotkb": "RPN7; P8283.8", "gene_names_refseq": "RPN7", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN7", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN7", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (sce:YPR108W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 27, "publication_id_list": "12504901;14562095;14562106;15102831;17322287;18407956;19029916;19446323;19779198;19795423;19823750;20486117;20702584;22814378;22927375;23749301;24374639;24706844;26744777;26929360;27821475;32597660;33481703;33491328;9169875;9697412;9741626", "class_list": "", "function": "Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4A6;E9P8W9", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q06103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06148-1", "uniprot_id": "NHEJ1_YEAST", "mass": 39116.0, "length": 342, "protein_name": "Non-homologous end-joining protein 1", "gene_name": "NEJ1", "organism": "Yeast", "refseq_name": "Nej1p", "refseq_ac": "NP_013367", "gene_names_uniprotkb": "NEJ1; LIF2", "gene_names_refseq": "LIF2; NEJ1", "protein_names_uniprotkb": "Non-homologous end-joining protein 1", "protein_names_refseq": "Nej1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR265C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11676923;11701889;11711435;11740566;12399380;12769859;14562095;14562106;16314503;16951060;17101301;17322287;17567543;19571008;20702584;23749301;24374639;33481703;33491328;34244791;9169871", "class_list": "", "function": "Involved in non-homologous end joining (NHEJ). Facilitates the transport of LIF1 into the nucleus, where it can interact with DNA ligase DNL4 to repair double-strand breaks (DSB). Mediates mating-type regulation of NHEJ. Prevents chromosome circularization by NHEJ in absence of telomerase., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYR3;Q0P6Z6;Q0P6Z7;Q0P707", "ec_number_list": "", "go_molecular_function": "GO:0045027 DNA end binding", "go_cellular_component": "GO:0032807 DNA ligase IV complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0035861 site of double-strand break", "go_biological_process": "GO:0045002 double-strand break repair via single-strand annealing;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0035825 homologous recombination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q06148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06205-1", "uniprot_id": "FKBP4_YEAST", "mass": 43903.0, "length": 392, "protein_name": "FK506-binding protein 4", "gene_name": "FPR4", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase FPR4", "refseq_ac": "NP_013554", "gene_names_uniprotkb": "FPR4; L9324.3", "gene_names_refseq": "FPR4", "protein_names_uniprotkb": "FK506-binding protein 4; 5.2.1.8; Histone proline isomerase; PPIase; Peptidyl-prolyl cis-trans isomerase; Rotamase", "protein_names_refseq": "peptidylprolyl isomerase FPR4", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR449W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11875433;14562106;14981505;15686447;16846601;16959570;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;23888048;24374639;30516470;32597660;33481703;33491328;9169871;9371805", "class_list": "", "function": "PPIase that acts as a histone chaperone (PubMed:14981505, PubMed:16846601). Histone proline isomerase that increases the rate of cis-trans isomerization at 'Pro-17' (H3P16), 'Pro-31' (H3P30) and 'Pro-39 (H3P38) on the histone H3 N-terminal tail (PubMed:16959570, PubMed:23888048). H3P16 and H3P30 are the major proline targets with little activity shown against H3P38 (PubMed:23888048). H3P38 isomerization influences SET2-mediated H3K36 methylation thereby regulating gene expression (PubMed:16959570)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ83", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0005527 macrolide binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0040029 epigenetic regulation of gene expression;GO:0043007 maintenance of rDNA", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q06205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06208-1", "uniprot_id": "RIF2_YEAST", "mass": 45643.0, "length": 395, "protein_name": "Protein RIF2", "gene_name": "RIF2", "organism": "Yeast", "refseq_name": "Rif2p", "refseq_ac": "NP_013558", "gene_names_uniprotkb": "RIF2", "gene_names_refseq": "RIF2", "protein_names_uniprotkb": "Protein RIF2; RAP1-interacting factor 2", "protein_names_refseq": "Rif2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR453C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17322287;24374639;33481703;9087429;9169871", "class_list": "", "function": "Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ87;E9P8Y1", "ec_number_list": "", "go_molecular_function": "GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0070187 shelterin complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0007004 telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06218-1", "uniprot_id": "DBP9_YEAST", "mass": 68060.0, "length": 594, "protein_name": "ATP-dependent RNA helicase DBP9", "gene_name": "DBP9", "organism": "Yeast", "refseq_name": "ATP-dependent DNA/RNA helicase", "refseq_ac": "NP_013378", "gene_names_uniprotkb": "DBP9; L9328.3", "gene_names_refseq": "DBP9", "protein_names_uniprotkb": "ATP-dependent RNA helicase DBP9; 3.6.4.13; DEAD box protein 9", "protein_names_refseq": "ATP-dependent DNA/RNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR276C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11565753;15028736;17322287;24374639;33491328;9169871", "class_list": "", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYS3;Q66R46", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06580-1", "uniprot_id": "MLC2_YEAST", "mass": 18521.0, "length": 163, "protein_name": "Myosin light chain 2", "gene_name": "MLC2", "organism": "Yeast", "refseq_name": "Mlc2p", "refseq_ac": "NP_015514", "gene_names_uniprotkb": "MLC2; P9677.10", "gene_names_refseq": "MLC2", "protein_names_uniprotkb": "Myosin light chain 2; Calmodulin-like myosin light chain MLC2; MYO1 light chain 2; Myosin-1 light chain", "protein_names_refseq": "Mlc2p", "tax_id": 559292, "disease": "infantile-onset myofibrillar myopathy 12 with cardiomyopathy (Disease Ontology:DOID:0051044); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316)", "pathway": " (sce:YPR188C); (R-SCE-5627123)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562095;14562106;15210731;17322287;19823750;22218487;24374639;33481703;33491328;9169875", "class_list": "", "function": "Regulatory light chain for the class II conventional myosin MYO1. May play a role in the disassembly of the MYO1 ring at the bud neck at the end of its contraction during cytokinesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4I8", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding;GO:0032038 myosin II heavy chain binding;GO:0140659 cytoskeletal motor regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016460 myosin II complex;GO:0000131 incipient cellular bud site;GO:0000142 cellular bud neck contractile ring;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0031032 actomyosin structure organization;GO:0000281 mitotic cytokinesis;GO:1902404 mitotic actomyosin contractile ring contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q06580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06697-1", "uniprot_id": "CDC73_YEAST", "mass": 44456.0, "length": 393, "protein_name": "Cell division control protein 73", "gene_name": "CDC73", "organism": "Yeast", "refseq_name": "Cdc73p", "refseq_ac": "NP_013522", "gene_names_uniprotkb": "CDC73", "gene_names_refseq": "CDC73", "protein_names_uniprotkb": "Cell division control protein 73; RNA polymerase-associated protein CDC73", "protein_names_refseq": "Cdc73p", "tax_id": 559292, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hyperparathyroidism (Disease Ontology:DOID:13543); parathyroid carcinoma (Disease Ontology:DOID:1540); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YLR418C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10219085;11884586;12242279;15643076;16246725;18407956;19795423;19823750;20190278;23749301;24374639;33481703;33491328;9032243;9169871", "class_list": "", "function": "The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ54", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0045910 negative regulation of DNA recombination;GO:0006362 transcription elongation by RNA polymerase I;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q06697-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07457-1", "uniprot_id": "BRE1_YEAST", "mass": 80692.0, "length": 700, "protein_name": "E3 ubiquitin-protein ligase BRE1", "gene_name": "BRE1", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase BRE1", "refseq_ac": "NP_010209", "gene_names_uniprotkb": "BRE1", "gene_names_refseq": "BRE1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase BRE1; 2.3.2.27; Brefeldin A-sensitivity protein 1; RING-type E3 ubiquitin transferase BRE1", "protein_names_refseq": "E3 ubiquitin-protein ligase BRE1", "tax_id": 559292, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YDL074C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12535538;12535539;12876294;14562095;14562106;15280549;15632065;21177495;23749301;24374639;33491328;9169867", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRS5", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0033503 HULC complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0031509 subtelomeric heterochromatin formation;GO:0016567 protein ubiquitination;GO:0006366 transcription by RNA polymerase II;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q07457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07800-1", "uniprot_id": "PSR1_YEAST", "mass": 47931.0, "length": 427, "protein_name": "Phosphatase PSR1", "gene_name": "PSR1", "organism": "Yeast", "refseq_name": "phosphatase", "refseq_ac": "NP_013091", "gene_names_uniprotkb": "PSR1; L1341", "gene_names_refseq": "PSR1", "protein_names_uniprotkb": "Phosphatase PSR1; 3.1.3.-; Plasma membrane sodium response protein 1", "protein_names_refseq": "phosphatase", "tax_id": 559292, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YLL010C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10777497;12090248;14562095;14562106;17287358;18407956;19779198;19795423;19823750;20489023;20702584;22106047;23749301;24374639;30516470;32597660;33481703;33491328;8810043;9169871", "class_list": "", "function": "Has phosphatase activity in vitro. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR2. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXZ2", "ec_number_list": "", "go_molecular_function": "GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:1903293 phosphatase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0006470 protein dephosphorylation;GO:0009651 response to salt stress;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q07800-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07963-1", "uniprot_id": "UBR2_YEAST", "mass": 216778.0, "length": 1872, "protein_name": "E3 ubiquitin-protein ligase UBR2", "gene_name": "UBR2", "organism": "Yeast", "refseq_name": "putative ubiquitin-protein ligase UBR2", "refseq_ac": "NP_013124", "gene_names_uniprotkb": "UBR2", "gene_names_refseq": "UBR2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR2; 2.3.2.27; RING-type E3 ubiquitin transferase UBR2; Ubiquitin-protein ligase E3 component N-recognin-1 homolog", "protein_names_refseq": "putative ubiquitin-protein ligase UBR2", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); cardiovascular system disease (Disease Ontology:DOID:1287); Johanson-Blizzard syndrome (Disease Ontology:DOID:14694); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (sce:YLR024C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10581257;12872131;14562095;14562106;15504724;17330950;18070918;18407956;19779198;20702584;22814378;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "E3 ubiquitin-protein ligase which probably functions outside the N-end rule pathway, since it lacks the residues essential for the degradation of N-end rule substrates. Mediates RPN4 ubiquitination and subsequent degradation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY26", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex;GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system;GO:0034620 cellular response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q07963-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08109-1", "uniprot_id": "HRD1_YEAST", "mass": 63535.0, "length": 551, "protein_name": "ERAD-associated E3 ubiquitin-protein ligase HRD1", "gene_name": "HRD1", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase HRD1", "refseq_ac": "NP_014630", "gene_names_uniprotkb": "HRD1; DER3", "gene_names_refseq": "DER3; HRD1", "protein_names_uniprotkb": "ERAD-associated E3 ubiquitin-protein ligase HRD1; 2.3.2.27; HMG-CoA reductase degradation protein 1; RING-type E3 ubiquitin transferase HRD1", "protein_names_refseq": "E3 ubiquitin-protein ligase HRD1", "tax_id": 559292, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (sce:YOL013C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10218484;10547371;10793145;11018054;11139575;11146622;11390656;14562095;14562106;16619026;16873066;17330950;18407956;19684113;19779198;20005842;21074049;21126336;23749301;24374639;28682307;32327568;32597660;33481703;33491328;8970163;9169874;9437001", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). In ERAD-L, facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with DER1 (PubMed:32327568). Both proteins have lateral gates facing each other which form a channel through the ER membrane and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568). Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1. ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W254", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex;GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q08109-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08229-1", "uniprot_id": "NBA1_YEAST", "mass": 55923.0, "length": 501, "protein_name": "Protein NBA1", "gene_name": "NBA1", "organism": "Yeast", "refseq_name": "Nba1p", "refseq_ac": "NP_014571", "gene_names_uniprotkb": "NBA1", "gene_names_refseq": "NBA1", "protein_names_uniprotkb": "Protein NBA1; NAP1 and bud neck-associated protein 1", "protein_names_refseq": "Nba1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL070C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562095;14562106;14574415;15665377;16702403;18086883;19684113;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169874", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 48, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Z7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032153 cell division site;GO:0005621 cellular bud scar;GO:0005935 cellular bud neck;GO:0032174 cellular bud neck septin collar", "go_biological_process": "GO:0045184 establishment of protein localization;GO:0007120 axial cellular bud site selection;GO:1901900 regulation of protein localization to cell division site", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q08229-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08231-1", "uniprot_id": "THP1_YEAST", "mass": 52678.0, "length": 455, "protein_name": "Nuclear mRNA export protein THP1", "gene_name": "THP1", "organism": "Yeast", "refseq_name": "Thp1p", "refseq_ac": "NP_014569", "gene_names_uniprotkb": "THP1; BUD29; O1140", "gene_names_refseq": "BUD29; THP1", "protein_names_uniprotkb": "Nuclear mRNA export protein THP1; Bud site selection protein 29", "protein_names_refseq": "Thp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL072W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11139493;12206772;12411502;12702719;14562095;14562106;14718168;15311284;24374639;9169874;9178509", "class_list": "", "function": "Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. THP1 binds to RNA in vitro., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Z5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0070390 transcription export complex 2", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0071028 nuclear mRNA surveillance;GO:0006406 mRNA export from nucleus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08273-1", "uniprot_id": "RBX1_YEAST", "mass": 13940.0, "length": 121, "protein_name": "RING-box protein HRT1", "gene_name": "HRT1", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase complex subunit HRT1", "refseq_ac": "NP_014508", "gene_names_uniprotkb": "HRT1; RBX1; ROC1", "gene_names_refseq": "HRT1; HRT2; RBX1; ROC1", "protein_names_uniprotkb": "RING-box protein HRT1; E3 ubiquitin-protein ligase complex SCF subunit HRT1; High level expression reduces Ty3 transposition protein 1; RING-box protein 1; Regulator of cullins protein 1", "protein_names_refseq": "SCF ubiquitin ligase complex subunit HRT1", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YOL133W); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-8854050); (R-SCE-983168)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10213691;10213692;10230407;10385629;10579999;10880467;12676951;17296727;19779198;20489023;24374639;33491328;8896270;9169874", "class_list": "", "function": "Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. Recruits the E2 ubiquitin-conjugating enzyme CDC34/UBC3 to the complex and brings it into close proximity to the substrate. Also stimulates CDC34/UBC3 autoubiquitination and promotes the neddylation of CDC53 and RTT101. Component of the SCF(CDC4) ubiquitin ligase required for ubiquitination of the cyclin-dependent kinase inhibitor SIC1 and for the G1-to-S phase transition. Component of the RTT101(MMS1-MMS22) ubiquitin ligase that promotes fork progression through damaged DNA or natural pause sites. Component of the CRL3(ELA1) ubiquitin ligase required for ubiquitination of RPB1, the largest subunit of RNA polymerase II (Pol II), which targets Pol II for proteasomal degradation in DNA-damaged cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1T5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0031461 cullin-RING ubiquitin ligase complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q08273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08446-1", "uniprot_id": "SGT1_YEAST", "mass": 44860.0, "length": 395, "protein_name": "Protein SGT1", "gene_name": "SGT1", "organism": "Yeast", "refseq_name": "co-chaperone SGT1", "refseq_ac": "NP_014700", "gene_names_uniprotkb": "SGT1; YOR29-08", "gene_names_refseq": "SGT1", "protein_names_uniprotkb": "Protein SGT1; Suppressor of G2 allele of SKP1", "protein_names_refseq": "co-chaperone SGT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR057W); (R-SCE-844456)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10445024;12456005;14562106;17322287;17330950;17563356;18407956;19398558;19779198;19795423;19823750;20702584;21177495;22106047;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9133743;9169874", "class_list": "", "function": "Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Required for both entry into S phase and kinetochore function. Also involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W2C0;E9P8U7", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q08446-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08649-1", "uniprot_id": "ESA1_YEAST", "mass": 52613.0, "length": 445, "protein_name": "Histone acetyltransferase ESA1", "gene_name": "ESA1", "organism": "Yeast", "refseq_name": "NuA4 histone acetyltransferase complex catalytic subunit ESA1", "refseq_ac": "NP_014887", "gene_names_uniprotkb": "ESA1; O5257", "gene_names_refseq": "ESA1; KAT5; TAS1", "protein_names_uniprotkb": "Histone acetyltransferase ESA1; 2.3.1.-; 2.3.1.48; Protein 2-hydroxyisobutyryltransferase ESA1; Protein acetyltransferase ESA1; Protein crotonyltransferase ESA1", "protein_names_refseq": "NuA4 histone acetyltransferase complex catalytic subunit ESA1", "tax_id": 559292, "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YOR244W); (R-SCE-6804758)", "pathway_count": 2, "publication_count": 38, "publication_id_list": "10082517;10487762;10835360;10911987;11100734;11106757;11545749;12110674;12353039;12368900;12379856;14562106;14690591;15045029;15175650;15353583;15494307;15923609;15949446;15964809;16543223;17223684;18245364;18407956;19822662;22020126;22539722;23749301;24374639;29765047;31699900;33229814;33481703;33491328;8972580;9169874;9520405;9858608", "class_list": "", "function": "Catalytic component of the NuA4 histone acetyltransferase (HAT), a multiprotein complex involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:12379856, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:16543223, PubMed:18245364, PubMed:9520405, PubMed:9858608). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Acetylation of histones gives a specific tag for epigenetic transcription initiation and elongation (PubMed:16543223, PubMed:19822662). Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Involved in cell cycle progression (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Recruitment to promoters depends on H3K4me (PubMed:10082517, PubMed:10835360, PubMed:10911987, PubMed:12353039, PubMed:15045029, PubMed:15175650, PubMed:15494307, PubMed:15923609, PubMed:18245364, PubMed:9858608). Also acetylates non-histone proteins, such as ATG3 and PAH1 (PubMed:22539722, PubMed:29765047). Regulates autophagy by acetylating ATG3, controlling interaction the interaction between ATG3 and ATG8 and ATG8 lipidation (PubMed:22539722). Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of PAH1, thereby promoting the synthesis of diacylglycerol (PubMed:29765047). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (PubMed:31699900). Catalyzes histone crotonylation (PubMed:31699900)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W2U6", "ec_number_list": "2.7.11.1;2.3.1.48;2.3.1.-", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0140068 histone crotonyltransferase activity;GO:0003682 chromatin binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000785 chromatin;GO:0032777 piccolo histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016239 positive regulation of macroautophagy;GO:0000183 rDNA heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q08649-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08754-1", "uniprot_id": "BUD7_YEAST", "mass": 84830.0, "length": 746, "protein_name": "Bud site selection protein 7", "gene_name": "BUD7", "organism": "Yeast", "refseq_name": "exomer complex subunit", "refseq_ac": "NP_014943", "gene_names_uniprotkb": "BUD7", "gene_names_refseq": "BUD7", "protein_names_uniprotkb": "Bud site selection protein 7", "protein_names_refseq": "exomer complex subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR299W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11452010;14562095;14562106;16498409;16855022;17000877;18407956;19779198;23749301;24374639;32597660;33491328;9169874", "class_list": "", "function": "Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3. May be involved in positioning the proximal bud pole signal., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Z9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030140 trans-Golgi network transport vesicle;GO:0034044 exomer complex", "go_biological_process": "GO:0015031 protein transport;GO:0006893 Golgi to plasma membrane transport;GO:0006031 chitin biosynthetic process;GO:0000282 cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q08754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12018-1", "uniprot_id": "CDC53_YEAST", "mass": 93944.0, "length": 815, "protein_name": "Cell division control protein 53", "gene_name": "CDC53", "organism": "Yeast", "refseq_name": "cullin CDC53", "refseq_ac": "NP_010150", "gene_names_uniprotkb": "CDC53; D2190", "gene_names_refseq": "CDC53", "protein_names_uniprotkb": "Cell division control protein 53; Cullin-A; E3 ubiquitin ligase complex SCF subunit CDC53", "protein_names_refseq": "cullin CDC53", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL132W); (R-SCE-8854050); (R-SCE-917937); (R-SCE-983168)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10213692;10385629;11283612;14562095;14562106;14747994;16421250;19763088;19795423;19823750;19942853;20489023;23749301;24374639;24909858;33491328;7813440;8943317;8972577;9169867;9312054;9346238;9346239;9499404;9736614", "class_list": "", "function": "Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The SCF complex associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the SCF complex depends on the type of F-box protein. SCF(CDC4) controls the G1-to-S phase transition; it directs ubiquitination of the phosphorylated CDK inhibitor SIC1 and of CDC6. SCF(CDC4) directs ubiquitination of GCN4. SCF(GRR1) directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. SCF(MET30) directs ubiquitination of MET4. SCF(DIA2) is specifically involved in the pheromone induced degradation of phosphorylated TEC1. SCF(MDM30) seems to direct ubiquitination of FZ01. Involved in the regulation of methionine biosynthesis genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRL7", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q12018-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12030-1", "uniprot_id": "TAF10_YEAST", "mass": 23019.0, "length": 206, "protein_name": "SAGA complex/transcription factor TFIID complex subunit TAF10", "gene_name": "TAF10", "organism": "Yeast", "refseq_name": "Taf10p", "refseq_ac": "NP_010451", "gene_names_uniprotkb": "TAF10; TAF23; TAF25; YD9489.02", "gene_names_refseq": "TAF10; TAF23; TAF25", "protein_names_uniprotkb": "SAGA complex/transcription factor TFIID complex subunit TAF10; TAFII-23; TAFII-25; TAFII23; TAFII25; TBP-associated factor 10; TBP-associated factor 25 kDa; Transcription initiation factor TFIID subunit 10; p25", "protein_names_refseq": "Taf10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR167W); (R-SCE-674695); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042)", "pathway_count": 6, "publication_count": 39, "publication_id_list": "10026213;10788514;10864329;11238921;11295558;11940675;12052880;12093743;12138208;12446794;12516863;12840001;14562106;15260971;15448131;15647753;17563356;18407956;19731963;19779198;20190278;20489023;20702584;21126336;21177495;23749301;24374639;25216679;28918903;31969703;32597660;33229814;33481703;33491328;33864814;8662725;9169867;9674426;9695952", "class_list": "", "function": "Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex (PubMed:10788514, PubMed:12052880, PubMed:12138208, PubMed:25216679). Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (PubMed:11238921, PubMed:12516863, PubMed:15448131). SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:9674426). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:12840001, PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VSE7", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q12030-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12051-1", "uniprot_id": "GGPPS_YEAST", "mass": 38651.0, "length": 335, "protein_name": "Geranylgeranyl pyrophosphate synthase BTS1", "gene_name": "BTS1", "organism": "Yeast", "refseq_name": "farnesyltranstransferase", "refseq_ac": "NP_015256", "gene_names_uniprotkb": "BTS1", "gene_names_refseq": "BTS1", "protein_names_uniprotkb": "Geranylgeranyl pyrophosphate synthase BTS1; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.-; 2.5.1.10; 2.5.1.1; 2.5.1.29; BET2 suppressor protein 1; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; GGPP synthase; GGPPSase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "farnesyltranstransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL069C); (R-SCE-9969896)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;15296494;16554305;17322287;17535895;19245203;24374639;33229814;33491328;7665600;9169875", "class_list": "", "function": "Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3U6", "ec_number_list": "2.5.1.1;2.5.1.10;2.5.1.29;2.5.1.-", "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0046872 metal ion binding;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0033384 geranyl diphosphate biosynthetic process;GO:0045337 farnesyl diphosphate biosynthetic process;GO:0015031 protein transport;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12060-1", "uniprot_id": "HFI1_YEAST", "mass": 54466.0, "length": 488, "protein_name": "SAGA complex subunit HFI1", "gene_name": "HFI1", "organism": "Yeast", "refseq_name": "Hfi1p", "refseq_ac": "NP_015069", "gene_names_uniprotkb": "HFI1; ADA1; GAN1; SUP110", "gene_names_refseq": "ADA1; GAN1; HFI1; SRM12; SUP110", "protein_names_uniprotkb": "SAGA complex subunit HFI1; General activator of nitrogen pathway genes protein 1; Transcriptional coactivator HFI1/ADA1", "protein_names_refseq": "Hfi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL254W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10026213;10048020;10864329;12186975;12446794;14562106;15260971;15647753;18407956;19779198;20489023;23749301;24374639;25216679;28918903;31969703;32597660;33481703;33491328;33864814;9154821;9169875;9674426;9885573", "class_list": "", "function": "Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:10048020, PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12186975, PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3B7;O00039;Q02813", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q12060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12098-1", "uniprot_id": "SLX4_YEAST", "mass": 84362.0, "length": 748, "protein_name": "Structure-specific endonuclease subunit SLX4", "gene_name": "SLX4", "organism": "Yeast", "refseq_name": "Slx4p", "refseq_ac": "NP_013236", "gene_names_uniprotkb": "SLX4; L3140", "gene_names_refseq": "SLX4", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX4; Synthetic lethal of unknown function protein 4", "protein_names_refseq": "Slx4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR135W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11139495;12228808;12832395;14562095;14562106;15834151;15975089;16267268;17094803;17322287;17563356;17636031;18407956;18471978;18579504;20190278;20382573;20670896;23749301;24374639;32597660;33481703;33491328;34965436;9169871", "class_list": "", "function": "Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro. Interacts with the structure-specific RAD1-RAD10 endonuclease and promotes RAD1-RAD10-dependent 3'-non-homologous tail removal (NHTR) during repair of double-strand breaks by single-strand annealing. SLX4 also promotes recovery from DNA-alkylation-induced replisome stalling during DNA replication by facilitating the error-free mode of lesion bypass. This does not require SLX1 or RAD1-RAD10, but probably RTT107., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYD0", "ec_number_list": "", "go_molecular_function": "GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000228 nuclear chromosome;GO:0033557 Slx1-Slx4 complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q12098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12114-1", "uniprot_id": "CHS5_YEAST", "mass": 73639.0, "length": 671, "protein_name": "Chitin biosynthesis protein CHS5", "gene_name": "CHS5", "organism": "Yeast", "refseq_name": "Chs5p", "refseq_ac": "NP_013434", "gene_names_uniprotkb": "CHS5; CAL3; L8543.18", "gene_names_refseq": "CAL3; CHS5", "protein_names_uniprotkb": "Chitin biosynthesis protein CHS5; Protein CAL3", "protein_names_refseq": "Chs5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR330W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "12912901;14562095;14562106;15715908;16498409;16818716;16855022;17000877;17330950;17563356;18407956;19779198;19795423;19823750;21126336;21177495;22106047;23749301;24374639;28270554;31208443;32597660;33481703;33491328;8197125;8994808;9008706;9111317;9169871", "class_list": "", "function": "Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. Also involved in targeting FUS1 to sites of polarized growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYX2", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0034044 exomer complex;GO:0043332 mating projection tip", "go_biological_process": "GO:0015031 protein transport;GO:0006355 regulation of DNA-templated transcription;GO:0006032 chitin catabolic process;GO:0006893 Golgi to plasma membrane transport;GO:0000282 cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q12114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12163-1", "uniprot_id": "NBP2_YEAST", "mass": 26571.0, "length": 236, "protein_name": "NAP1-binding protein 2", "gene_name": "NBP2", "organism": "Yeast", "refseq_name": "adaptor protein NBP2", "refseq_ac": "NP_010446", "gene_names_uniprotkb": "NBP2", "gene_names_refseq": "NBP2", "protein_names_uniprotkb": "NAP1-binding protein 2", "protein_names_refseq": "adaptor protein NBP2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR162C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;14573466;14685261;16977319;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSE2", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade;GO:0071852 fungal-type cell wall organization or biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q12163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12166-1", "uniprot_id": "LEU9_YEAST", "mass": 67200.0, "length": 604, "protein_name": "2-isopropylmalate synthase 2, mitochondrial", "gene_name": "LEU9", "organism": "Yeast", "refseq_name": "2-isopropylmalate synthase LEU9", "refseq_ac": "NP_014751", "gene_names_uniprotkb": "LEU9; YOR3227w", "gene_names_refseq": "LEU9", "protein_names_uniprotkb": "2-isopropylmalate synthase 2, mitochondrial; 2.3.3.13; Alpha-IPM synthase 2; Alpha-isopropylmalate synthase 2; Alpha-isopropylmalate synthase II", "protein_names_refseq": "2-isopropylmalate synthase LEU9", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR108W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10790691;14562095;14562106;16823961;19795423;19823750;24374639;33491328;9169874;9200815", "class_list": "", "function": "Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible for about 20% of alpha-IPMS activity. Involved in leucine synthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2G7", "ec_number_list": "2.3.3.13", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003852 2-isopropylmalate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009098 L-leucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q12166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12234-1", "uniprot_id": "RUD3_YEAST", "mass": 56069.0, "length": 484, "protein_name": "GRIP domain-containing protein RUD3", "gene_name": "RUD3", "organism": "Yeast", "refseq_name": "Rud3p", "refseq_ac": "NP_014859", "gene_names_uniprotkb": "RUD3; GRP1; YOR50-6", "gene_names_refseq": "GRP1; RUD3", "protein_names_uniprotkb": "GRIP domain-containing protein RUD3; Golgin-related protein 1; Relieves USO1-1 transport defect protein 3", "protein_names_refseq": "Rud3p", "tax_id": 559292, "disease": "dystonia 22, juvenile-onset (Disease Ontology:DOID:0060966); dystonia 22, adult-onset (Disease Ontology:DOID:0060967)", "pathway": " (sce:YOR216C); (R-SCE-6811438)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10512869;10562277;12646213;14562095;14562106;15504911;15665377;17330950;17563356;18407956;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;33481703;33491328;33502312;8840505;9169874", "class_list": "", "function": "Involved in the structural organization of the cis-Golgi and in vesicle targeting/fusion stages of ER to Golgi transport., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2S2", "ec_number_list": "", "go_molecular_function": "GO:0051020 GTPase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q12234-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12300-1", "uniprot_id": "RGT2_YEAST", "mass": 83159.0, "length": 763, "protein_name": "High glucose sensor RGT2", "gene_name": "RGT2", "organism": "Yeast", "refseq_name": "glucose sensor", "refseq_ac": "NP_010143", "gene_names_uniprotkb": "RGT2; D2160", "gene_names_refseq": "RGT2", "protein_names_uniprotkb": "High glucose sensor RGT2; Low-affinity glucose receptor RGT2; Low-affinity transporter-like sensor RGT2; Restores glucose transport protein 2", "protein_names_refseq": "glucose sensor", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL138W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14755054;16847258;1874412;24374639;27630263;33481703;33491328;8901598;8972577;9169867;9564039", "class_list": "", "function": "Low-affinity high glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:14755054, PubMed:27630263, PubMed:9564039). The transporter-like sensor generates an intracellular signal in the presence of high levels of glucose to promote high glucose-induced expression of HXT1 (PubMed:9564039). Binding of glucose to the RGT2 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (PubMed:27630263, PubMed:8901598). Even though RGT2 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VRL0", "ec_number_list": "", "go_molecular_function": "GO:0005351 carbohydrate:proton symporter activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0010255 glucose mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12306-1", "uniprot_id": "SUMO_YEAST", "mass": 11597.0, "length": 101, "protein_name": "Small ubiquitin-related modifier", "gene_name": "SMT3", "organism": "Yeast", "refseq_name": "SUMO family protein SMT3", "refseq_ac": "NP_010798", "gene_names_uniprotkb": "SMT3; D9719.15", "gene_names_refseq": "SMT3", "protein_names_uniprotkb": "Small ubiquitin-related modifier; SUMO; Suppressor of mif two; Ubiquitin-like protein SMT3", "protein_names_refseq": "SUMO family protein SMT3", "tax_id": 559292, "disease": "orofacial cleft 10 (Disease Ontology:DOID:0080403); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDR510W); (R-SCE-3065676); (R-SCE-3065678); (R-SCE-3065679); (R-SCE-3108214); (R-SCE-3232118); (R-SCE-3899300); (R-SCE-4085377); (R-SCE-4551638); (R-SCE-4570464); (R-SCE-4615885); (R-SCE-9615933); (R-SCE-9793242); (R-SCE-9856649)", "pathway_count": 14, "publication_count": 21, "publication_id_list": "10882122;12021447;14562106;17287358;17322287;17330950;18407956;19779198;19795423;19823750;21126336;21177495;24155900;24374639;28166236;32597660;33481703;33491328;33502312;9169867;9312010", "class_list": "", "function": "Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer (PubMed:9312010). Sumoylation, the attachment of SUMO to target proteins, regulates multiple cellular events (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTD1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005940 septin ring;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus", "go_biological_process": "GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12306-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12315-1", "uniprot_id": "GLE1_YEAST", "mass": 62073.0, "length": 538, "protein_name": "mRNA export factor GLE1", "gene_name": "GLE1", "organism": "Yeast", "refseq_name": "nucleoporin GLE1", "refseq_ac": "NP_010074", "gene_names_uniprotkb": "GLE1; BRR3; D1049; RSS1", "gene_names_refseq": "BRR3; GLE1; NLE2; RSS1", "protein_names_uniprotkb": "mRNA export factor GLE1; Nuclear pore protein GLE1; Nucleoporin GLE1; RNA export factor GLE1", "protein_names_refseq": "nucleoporin GLE1", "tax_id": 559292, "disease": "lethal congenital contracture syndrome 1 (Disease Ontology:DOID:0060559)", "pathway": " (sce:YDL207W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10523319;10610322;10684247;11336711;12791264;14562106;15208322;17563356;18407956;20190278;23749301;24374639;33229814;33481703;33491328;8848052;9046097;9169867", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC probably by binding the ATP-dependent RNA helicase DBP5 and GFD1 at the cytoplasmic side of the NPC. These interactions are thought to be important for the dissociation of transport proteins such as the heterogeneous nuclear ribonucleoprotein (hnRNP) NAB2 from exported mRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VRE7", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008047 enzyme activator activity;GO:0000822 inositol hexakisphosphate binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031965 nuclear membrane", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006449 regulation of translational termination;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0006409 tRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q12315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12369-1", "uniprot_id": "SFI1_YEAST", "mass": 112979.0, "length": 946, "protein_name": "Protein SFI1", "gene_name": "SFI1", "organism": "Yeast", "refseq_name": "Sfi1p", "refseq_ac": "NP_013098", "gene_names_uniprotkb": "SFI1; L1373", "gene_names_refseq": "SFI1", "protein_names_uniprotkb": "Protein SFI1; Suppressor of fermentation induced loss of stress resistance protein 1", "protein_names_refseq": "Sfi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL003W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10455233;14504268;14562095;16785321;17287358;17563356;18407956;19520826;19779198;19795423;19823750;20489023;21177495;23749301;24374639;24954044;32597660;33481703;33491328;8810043;9169871", "class_list": "", "function": "Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY00", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005825 half bridge of spindle pole body", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0051225 spindle assembly;GO:0030474 spindle pole body duplication", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12369-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12373-1", "uniprot_id": "HIF1_YEAST", "mass": 43428.0, "length": 385, "protein_name": "HAT1-interacting factor 1", "gene_name": "HIF1", "organism": "Yeast", "refseq_name": "Hif1p", "refseq_ac": "NP_013078", "gene_names_uniprotkb": "HIF1; L1205", "gene_names_refseq": "HIF1", "protein_names_uniprotkb": "HAT1-interacting factor 1", "protein_names_refseq": "Hif1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL022C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;14761951;15099519;18407956;19779198;24374639;24946827;27618665;32597660;33491328;9046100;9169871", "class_list": "", "function": "Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXY2", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000123 histone acetyltransferase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12373-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12407-1", "uniprot_id": "YD199_YEAST", "mass": 77501.0, "length": 687, "protein_name": "Putative metabolite transport protein YDL199C", "gene_name": "D1209", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_010082", "gene_names_uniprotkb": "D1209", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative metabolite transport protein YDL199C", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL199C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16847258;18407956;19779198;22814378;23749301;24374639;33481703;33491328;8533471;9046097;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRF5", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0008643 carbohydrate transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12449-1", "uniprot_id": "AHA1_YEAST", "mass": 39436.0, "length": 350, "protein_name": "Hsp90 co-chaperone AHA1", "gene_name": "AHA1", "organism": "Yeast", "refseq_name": "Aha1p", "refseq_ac": "NP_010500", "gene_names_uniprotkb": "AHA1; YD8142.16; YD8142B.06", "gene_names_refseq": "AHA1", "protein_names_uniprotkb": "Hsp90 co-chaperone AHA1; Activator of Hsp90 ATPase protein 1", "protein_names_refseq": "Aha1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR214W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12504007;12604615;14562095;14562106;14739935;17322287;17563356;18407956;19779198;20702584;23749301;24374639;33481703;33491328;3515197;9169867", "class_list": "", "function": "Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity. Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N-terminal nucleotide-binding domain. Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSJ8;Q02565;Q7LIE3", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12449-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12514-1", "uniprot_id": "NOT5_YEAST", "mass": 65855.0, "length": 560, "protein_name": "General negative regulator of transcription subunit 5", "gene_name": "NOT5", "organism": "Yeast", "refseq_name": "CCR4-NOT core subunit NOT5", "refseq_ac": "NP_015397", "gene_names_uniprotkb": "NOT5; YP9499.27", "gene_names_refseq": "NOT5", "protein_names_uniprotkb": "General negative regulator of transcription subunit 5", "protein_names_refseq": "CCR4-NOT core subunit NOT5", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR072W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10490603;11733989;12215412;14562106;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169875;9463387;9511744", "class_list": "", "function": "Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W476", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0016567 protein ubiquitination;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q12514-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12753-1", "uniprot_id": "HAA1_YEAST", "mass": 76671.0, "length": 694, "protein_name": "Transcriptional activator HAA1", "gene_name": "HAA1", "organism": "Yeast", "refseq_name": "Haa1p", "refseq_ac": "NP_015333", "gene_names_uniprotkb": "HAA1; LPZ8W; YP9531.01; YP9723.08", "gene_names_refseq": "HAA1", "protein_names_uniprotkb": "Transcriptional activator HAA1", "protein_names_refseq": "Haa1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR008W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11504737;14562106;15665377;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;9169875", "class_list": "", "function": "Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 45, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W419", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006878 intracellular copper ion homeostasis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0033554 cellular response to stress", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q12753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6WNK7-1", "uniprot_id": "SUS1_YEAST", "mass": 11085.0, "length": 96, "protein_name": "SAGA complex subunit SUS1", "gene_name": "SUS1", "organism": "Yeast", "refseq_name": "Sus1p", "refseq_ac": "NP_878049", "gene_names_uniprotkb": "SUS1", "gene_names_refseq": "SUS1", "protein_names_uniprotkb": "SAGA complex subunit SUS1; Transcription and mRNA export factor SUS1", "protein_names_refseq": "Sus1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR111W-A)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "14718168;15260971;15311284;16510898;16760982;16855026;18003937;18488019;18667528;18923079;19269973;19328066;20007317;20230609;20395473;20434206;21749978;21749979;22106047;22771212;23599000;24374639;24705649;25216679;26912860;28918903;29598828;31969703;33481703;33864814;7813418", "class_list": "", "function": "Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes (PubMed:14718168, PubMed:15311284, PubMed:18923079). SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:16855026, PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:20395473). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903, PubMed:29598828). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). Within the SAGA complex, participates in a subcomplex with SGF11, SGF73 and UBP8 required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels (PubMed:16855026). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:16760982, PubMed:18003937, PubMed:19328066). SUS1 also has a role in mRNP biogenesis and maintenance of genome integrity through preventing RNA-mediated genome instability (PubMed:18667528). Has a role in response to DNA damage induced by methyl methane sulfonate (MMS) and replication arrest induced by hydroxyurea (PubMed:16510898). May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (PubMed:20230609)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQB1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0000932 P-body;GO:0071819 DUBm complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0071028 nuclear mRNA surveillance;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006406 mRNA export from nucleus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q6WNK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99220-1", "uniprot_id": "OS9_YEAST", "mass": 61258.0, "length": 542, "protein_name": "Protein OS-9 homolog", "gene_name": "YOS9", "organism": "Yeast", "refseq_name": "Yos9p", "refseq_ac": "NP_010342", "gene_names_uniprotkb": "YOS9; D4222", "gene_names_refseq": "YOS9", "protein_names_uniprotkb": "Protein OS-9 homolog", "protein_names_refseq": "Yos9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR057W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12077121;15556621;16168370;16168371;16168372;16873065;16873066;21074049;21177495;22262864;24374639;32327568;8789263;9169867", "class_list": "", "function": "Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. The recognition of targets is N-glycan specific. Functions in recruiting misfolded protein substrates in conjunction with HRD3 (PubMed:32327568)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VS43;Q04313", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex;GO:0034099 luminal surveillance complex", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway;GO:0030970 retrograde protein transport, ER to cytosol;GO:0002235 detection of unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99231-1", "uniprot_id": "YD12B_YEAST", "mass": 198839.0, "length": 1755, "protein_name": "Transposon Ty1-DR3 Gag-Pol polyprotein", "gene_name": "TY1B-DR3", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_620387", "gene_names_uniprotkb": "TY1B-DR3; YD8142B.01; YDRCTy1-2 POL", "gene_names_refseq": "YDR210W-D", "protein_names_uniprotkb": "Transposon Ty1-DR3 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR210C-D)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16093660;16093680;18407956;19779198;24374639;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSJ3", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99299-1", "uniprot_id": "AIM44_YEAST", "mass": 84846.0, "length": 758, "protein_name": "Altered inheritance of mitochondria protein 44", "gene_name": "AIM44", "organism": "Yeast", "refseq_name": "Aim44p", "refseq_ac": "NP_015167", "gene_names_uniprotkb": "AIM44; P2570", "gene_names_refseq": "AIM44; GPS1", "protein_names_uniprotkb": "Altered inheritance of mitochondria protein 44", "protein_names_refseq": "Aim44p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL158C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11309124;14562095;14562106;19300474;19779198;21177495;23749301;24374639;32597660;33481703;33491328;8948103;9169875", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3L0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005637 nuclear inner membrane;GO:0032153 cell division site;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0045185 maintenance of protein location;GO:0098841 protein localization to cell division site after cytokinesis;GO:1903473 positive regulation of mitotic actomyosin contractile ring contraction;GO:1990344 secondary cell septum biogenesis;GO:1901900 regulation of protein localization to cell division site", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99299-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D6W196-1", "uniprot_id": "CMC1_YEAST", "mass": 55715.0, "length": 494, "protein_name": "Truncated non-functional calcium-binding mitochondrial carrier SAL1-1", "gene_name": "SAL1", "organism": "Yeast", "refseq_name": "Ca(2+)-binding ATP:ADP antiporter SAL1", "refseq_ac": "NP_014316", "gene_names_uniprotkb": "SAL1; N2312", "gene_names_refseq": "SAL1", "protein_names_uniprotkb": "Truncated non-functional calcium-binding mitochondrial carrier SAL1-1; Suppressor of AAC2 lethality", "protein_names_refseq": "Ca(2+)-binding ATP:ADP antiporter SAL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL083W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12844361;14562106;15238515;17287358;19581448;24374639;8701611;8740422;9169873;9178508", "class_list": "", "function": "Calcium-dependent mitochondrial solute carrier., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P48233;Q45TY5;Q6WV05;Q96US1", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005471 ATP:ADP antiporter activity;GO:0005347 ATP transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0015866 ADP transport;GO:0015867 ATP transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "D6W196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13525-1", "uniprot_id": "COQ4_YEAST", "mass": 38627.0, "length": 335, "protein_name": "Ubiquinone biosynthesis protein COQ4, mitochondrial", "gene_name": "COQ4", "organism": "Yeast", "refseq_name": "ubiquinone biosynthesis protein COQ4", "refseq_ac": "NP_010490", "gene_names_uniprotkb": "COQ4; YD8142.01", "gene_names_refseq": "COQ4", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ4, mitochondrial; 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; 4.1.1.130; Coenzyme Q biosynthesis protein 4", "protein_names_refseq": "ubiquinone biosynthesis protein COQ4", "tax_id": 559292, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); spastic ataxia (Disease Ontology:DOID:0050952); primary coenzyme Q10 deficiency 7 (Disease Ontology:DOID:0070244)", "pathway": " (sce:YDR204W); (R-SCE-2142789)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11469793;14562095;15548532;15792955;16624818;17391640;19022396;24374639;9169867", "class_list": "", "function": "Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-hexaprenyl)benzoic acid into 2-methoxy-6-(all-trans-hexaprenyl)phenol during ubiquinone biosynthesis (By similarity). May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis (PubMed:15548532, PubMed:17391640, PubMed:19022396). Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides (PubMed:15548532, PubMed:17391640, PubMed:19022396)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSI5;Q03454", "ec_number_list": "4.1.1.130;2.1.1.-;2.1.1.114;2.1.1.64;2.7.-.-;1.14.99.60;1.14.13.253;2.1.1.201;3.5.-.-;1.14.15.45;1.14.15.46", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0120539 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O13525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13559-1", "uniprot_id": "YRF14_YEAST", "mass": 156367.0, "length": 1382, "protein_name": "Y' element ATP-dependent helicase protein 1 copy 4", "gene_name": "YRF1-4", "organism": "Yeast", "refseq_name": "Y' element ATP-dependent helicase protein 1 copy 4", "refseq_ac": "NP_013571", "gene_names_uniprotkb": "YRF1-4", "gene_names_refseq": "YRF1-4; YRF1", "protein_names_uniprotkb": "Y' element ATP-dependent helicase protein 1 copy 4; 5.6.2.-", "protein_names_refseq": "Y' element ATP-dependent helicase protein 1 copy 4", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR466W)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24374639;9169871;9837911", "class_list": "", "function": "Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ97", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O13559-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13577-1", "uniprot_id": "DIF1_YEAST", "mass": 15165.0, "length": 133, "protein_name": "Damage-regulated import facilitator 1", "gene_name": "DIF1", "organism": "Yeast", "refseq_name": "Dif1p", "refseq_ac": "NP_013541", "gene_names_uniprotkb": "DIF1", "gene_names_refseq": "DIF1; SDH1", "protein_names_uniprotkb": "Damage-regulated import facilitator 1", "protein_names_refseq": "Dif1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR437C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16278933;18832349;18838542;18851834;23749301;24374639;26970775;33481703;33491328;9169871", "class_list": "", "function": "Mediates the nuclear localization of RNR2 and RNR4, 2 subunits of the ribonucleotide reductase., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ71", "ec_number_list": "", "go_molecular_function": "GO:1990846 ribonucleoside-diphosphate reductase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O13577-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O14455-1", "uniprot_id": "RL36B_YEAST", "mass": 11135.0, "length": 100, "protein_name": "Large ribosomal subunit protein eL36B", "gene_name": "RPL36B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL36 RPL36B", "refseq_ac": "NP_015074", "gene_names_uniprotkb": "RPL36B; RPL39B; YPL249BC", "gene_names_refseq": "RPL36B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL36B; 60S ribosomal protein L36-B; L39; YL39", "protein_names_refseq": "60S ribosomal protein eL36 RPL36B", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL249C-A); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 16, "publication_id_list": "10601260;14562095;14562106;15665377;18782943;21126336;22096102;23749301;24374639;24524803;32597660;33481703;33491328;34965436;9169875;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3C1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000470 maturation of LSU-rRNA;GO:0180023 cytosolic large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O14455-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O14464-1", "uniprot_id": "RTC6_YEAST", "mass": 10698.0, "length": 93, "protein_name": "Large ribosomal subunit protein bL36m", "gene_name": "RTC6", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL36m RTC6", "refseq_ac": "NP_015141", "gene_names_uniprotkb": "RTC6; TAE4; YPL183BW", "gene_names_refseq": "RTC6; TAE4; bL36m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL36m; 54S ribosomal protein RTC6, mitochondrial; Restriction of telomere capping protein 6; Translation associated element 4", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL36m RTC6", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL183W-A)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;17322287;18845848;20691087;24374639;24675956;25609543;9169875;9392081", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543). bL36m may be involved in a process influencing telomere capping (PubMed:18845848, PubMed:20691087)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3I5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O14464-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O75012-1", "uniprot_id": "MRP10_YEAST", "mass": 10691.0, "length": 95, "protein_name": "Small ribosomal subunit protein mS37", "gene_name": "MRP10", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein mS37 MRP10", "refseq_ac": "NP_010238", "gene_names_uniprotkb": "MRP10", "gene_names_refseq": "MRP10; mS37", "protein_names_uniprotkb": "Small ribosomal subunit protein mS37; 37S ribosomal protein MRP10, mitochondrial; YmS-T", "protein_names_refseq": "mitochondrial 37S ribosomal protein mS37 MRP10", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL045W-A)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;17322287;24360785;24374639;25609543;28154081;33491328;9065385;9151978;9169867", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRV0", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O75012-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00425-1", "uniprot_id": "COX5B_YEAST", "mass": 17197.0, "length": 151, "protein_name": "Cytochrome c oxidase subunit 5B, mitochondrial", "gene_name": "COX5B", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit Vb", "refseq_ac": "NP_012155", "gene_names_uniprotkb": "COX5B", "gene_names_refseq": "COX5B", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5B, mitochondrial; Cytochrome c oxidase polypeptide Vb", "protein_names_refseq": "cytochrome c oxidase subunit Vb", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 16 (Disease Ontology:DOID:0070501); protein-energy malnutrition (Disease Ontology:DOID:11801); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (sce:YIL111W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;24374639;2546055;2548089;2824989;2986105;33491328;9169434;9169870", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVH6", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P00425-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00427-1", "uniprot_id": "COX6_YEAST", "mass": 17342.0, "length": 148, "protein_name": "Cytochrome c oxidase subunit 6, mitochondrial", "gene_name": "COX6", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit VI", "refseq_ac": "NP_011918", "gene_names_uniprotkb": "COX6", "gene_names_refseq": "COX6", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6, mitochondrial; Cytochrome c oxidase polypeptide VI", "protein_names_refseq": "cytochrome c oxidase subunit VI", "tax_id": 559292, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); ciliopathy (Disease Ontology:DOID:0060340); mitochondrial complex IV deficiency nuclear type 20 (Disease Ontology:DOID:0070505); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (sce:YHR051W); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10764779;10775262;1331058;14562106;17322287;24374639;2537949;30598554;30598556;33491328;6210289;6290493;7851399;8091229", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX6 may stabilize the region of CIV at the interface with CIII, supporting a role in formation or stability of the CIII(2)IV(2) SC (PubMed:30598554)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL00", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P00427-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00447-1", "uniprot_id": "SODM_YEAST", "mass": 25774.0, "length": 233, "protein_name": "Superoxide dismutase [Mn], mitochondrial", "gene_name": "SOD2", "organism": "Yeast", "refseq_name": "superoxide dismutase SOD2", "refseq_ac": "NP_011872", "gene_names_uniprotkb": "SOD2", "gene_names_refseq": "SOD2", "protein_names_uniprotkb": "Superoxide dismutase [Mn], mitochondrial; 1.15.1.1", "protein_names_refseq": "superoxide dismutase SOD2", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); sensorineural hearing loss (Disease Ontology:DOID:10003); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); exfoliation syndrome (Disease Ontology:DOID:13641); polyneuropathy (Disease Ontology:DOID:1389); bladder neck obstruction (Disease Ontology:DOID:13948); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); hypothyroidism (Disease Ontology:DOID:1459); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); carotid artery disease (Disease Ontology:DOID:3407); inclusion body myositis (Disease Ontology:DOID:3429); Canavan disease (Disease Ontology:DOID:3613); Leigh disease (Disease Ontology:DOID:3652); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); brain edema (Disease Ontology:DOID:4724); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); reactive arthritis (Disease Ontology:DOID:6196); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); abdominal aortic aneurysm (Disease Ontology:DOID:7693); infectious mononucleosis (Disease Ontology:DOID:8568); mycosis fungoides (Disease Ontology:DOID:8691); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (sce:YHR008C); (R-SCE-3299685)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;17322287;17761666;24374639;3072251;33491328;3882422;8091229", "class_list": "", "function": "Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 64, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV3", "ec_number_list": "1.8.-.-;1.15.1.1", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00447-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00856-1", "uniprot_id": "ATP8_YEAST", "mass": 5822.0, "length": 48, "protein_name": "ATP synthase protein 8", "gene_name": "ATP8", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit 8", "refseq_ac": "NP_009312", "gene_names_uniprotkb": "ATP8; AAP1", "gene_names_refseq": "AAP1; ATP8", "protein_names_uniprotkb": "ATP synthase protein 8; A6L; ATP-associated protein 1; F-ATPase subunit 8", "protein_names_refseq": "F1F0 ATP synthase subunit 8", "tax_id": 559292, "disease": "mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:Q0080)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24374639;6223276;6387398;9872396", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7P362", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P00856-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00931-1", "uniprot_id": "TRP_YEAST", "mass": 76626.0, "length": 707, "protein_name": "Tryptophan synthase", "gene_name": "TRP5", "organism": "Yeast", "refseq_name": "tryptophan synthase TRP5", "refseq_ac": "NP_011489", "gene_names_uniprotkb": "TRP5", "gene_names_refseq": "TRP5", "protein_names_uniprotkb": "Tryptophan synthase; 4.2.1.20", "protein_names_refseq": "tryptophan synthase TRP5", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL026C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;17563356;18407956;19779198;23749301;24374639;32597660;33229814;33481703;33491328;6276387;6282714;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUB2", "ec_number_list": "4.2.1.20", "go_molecular_function": "GO:0004834 tryptophan synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000162 L-tryptophan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P00931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01097-1", "uniprot_id": "ATIF_YEAST", "mass": 9870.0, "length": 85, "protein_name": "F(1)-ATPase inhibitor IF(1), mitochondrial", "gene_name": "INH1", "organism": "Yeast", "refseq_name": "ATPase inhibitor", "refseq_ac": "NP_010100", "gene_names_uniprotkb": "INH1; D1305", "gene_names_refseq": "INH1", "protein_names_uniprotkb": "F(1)-ATPase inhibitor IF(1), mitochondrial; ATPase inhibitory factor 1; IF(1); IF1", "protein_names_refseq": "ATPase inhibitor", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL181W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10705452;12167646;12186878;12809520;14562106;17322287;2138617;23407639;24374639;26420258;33481703;33491328;6458601;6619114;8533471;9169867", "class_list": "", "function": "Endogenous ATPase inhibitor, which inhibits specifically the reverse ATPase reaction of mitochondrial F(1)F(0)-type ATP synthase. It limits ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(0)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(0)-ATP synthase enzyme acts as an ATP hydrolase (PubMed:12167646, PubMed:12809520, PubMed:26420258). Functions through inserting its N-terminal part into the catalytically active F1-ATPase, thereby blocking its rotational movement and subsequently the ATP hydrolase activity (PubMed:23407639)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRH1", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042030 ATPase inhibitor activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032780 negative regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P01097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01149-1", "uniprot_id": "MFAL1_YEAST", "mass": 18642.0, "length": 165, "protein_name": "Mating factor alpha-1", "gene_name": "MF(ALPHA)1", "organism": "Yeast", "refseq_name": "Mf(Alpha)1p", "refseq_ac": "NP_015137", "gene_names_uniprotkb": "MF(ALPHA)1; MF-ALPHA-1; MFAL1", "gene_names_refseq": "MF(ALPHA)1", "protein_names_uniprotkb": "Mating factor alpha-1; Alpha-1 mating pheromone", "protein_names_refseq": "Mf(Alpha)1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL187W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "24374639;2834101;2959859;340452;6306574;6754095;9169875", "class_list": "", "function": "The active factor is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type a cells and synchronizing them with type alpha., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3I2;P25041", "ec_number_list": "", "go_molecular_function": "GO:0000772 mating pheromone activity;GO:1903135 cupric ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007618 mating;GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01149-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02381-1", "uniprot_id": "RMAR_YEAST", "mass": 47123.0, "length": 398, "protein_name": "Small ribosomal subunit protein uS3m", "gene_name": "VAR1", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein VAR1", "refseq_ac": "NP_009320", "gene_names_uniprotkb": "VAR1", "gene_names_refseq": "VAR1; uS3m", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3m; Ribosomal protein VAR1, mitochondrial", "protein_names_refseq": "mitochondrial 37S ribosomal protein VAR1", "tax_id": 559292, "disease": "", "pathway": " (sce:Q0140)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11278769;12392552;14576278;24374639;25609543;28154081;3549452;36482135;6754087;7770043;9755179;9872396", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). uS3m is essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits (PubMed:7770043)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYM3;A2KBL8;Q95946;Q9ZZW5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P02381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03882-1", "uniprot_id": "SCE1_YEAST", "mass": 27683.0, "length": 235, "protein_name": "Intron-encoded endonuclease I-SceI", "gene_name": "SCEI", "organism": "Yeast", "refseq_name": "intron-encoded endonuclease I-SceI", "refseq_ac": "NP_009324", "gene_names_uniprotkb": "SCEI; OMEGA; SECY", "gene_names_refseq": "SCEI", "protein_names_uniprotkb": "Intron-encoded endonuclease I-SceI; 21S rRNA intron maturase; 3.1.-.-; Homing endonuclease omega", "protein_names_refseq": "intron-encoded endonuclease I-SceI", "tax_id": 559292, "disease": "", "pathway": " (sce:Q0160)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14636596;2183191;24374639;3886163;6156002;9872396", "class_list": "", "function": "Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the 21S rRNA gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Specifically recognizes and cleaves the sequence 5'-TAGGGATAACAGGGTAAT-3'., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYJ1", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006314 intron homing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P03882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04046-1", "uniprot_id": "PUR1_YEAST", "mass": 56719.0, "length": 510, "protein_name": "Amidophosphoribosyltransferase", "gene_name": "ADE4", "organism": "Yeast", "refseq_name": "amidophosphoribosyltransferase", "refseq_ac": "NP_014029", "gene_names_uniprotkb": "ADE4; YM9952.02C", "gene_names_refseq": "ADE4", "protein_names_uniprotkb": "Amidophosphoribosyltransferase; 2.4.2.14; ATase; Glutamine phosphoribosylpyrophosphate amidotransferase", "protein_names_refseq": "amidophosphoribosyltransferase", "tax_id": 559292, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YMR300C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;18407956;20702584;21177495;24374639;30516470;32597660;33481703;33491328;6376509;9169872", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0C7", "ec_number_list": "2.4.2.14", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004044 amidophosphoribosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009113 purine nucleobase biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P04046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04076-1", "uniprot_id": "ARLY_YEAST", "mass": 51989.0, "length": 463, "protein_name": "Argininosuccinate lyase", "gene_name": "ARG4", "organism": "Yeast", "refseq_name": "argininosuccinate lyase ARG4", "refseq_ac": "NP_011882", "gene_names_uniprotkb": "ARG4", "gene_names_refseq": "ARG4", "protein_names_uniprotkb": "Argininosuccinate lyase; 4.3.2.1; ASAL; Arginosuccinase", "protein_names_refseq": "argininosuccinate lyase ARG4", "tax_id": 559292, "disease": "argininosuccinic aciduria (Disease Ontology:DOID:14755); hepatocellular carcinoma (Disease Ontology:DOID:684); amino acid metabolic disorder (Disease Ontology:DOID:9252); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YHR018C); (R-SCE-70635)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;17322287;17563356;18407956;24374639;3889658;6386606;8091229", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKW3", "ec_number_list": "4.3.2.1", "go_molecular_function": "GO:0004056 argininosuccinate lyase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042450 L-arginine biosynthetic process via ornithine", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04076-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04161-1", "uniprot_id": "PUR3_YEAST", "mass": 23540.0, "length": 214, "protein_name": "Phosphoribosylglycinamide formyltransferase", "gene_name": "ADE8", "organism": "Yeast", "refseq_name": "phosphoribosylglycinamide formyltransferase", "refseq_ac": "NP_010696", "gene_names_uniprotkb": "ADE8; D9509.26", "gene_names_refseq": "ADE8", "protein_names_uniprotkb": "Phosphoribosylglycinamide formyltransferase; 2.1.2.2; 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART", "protein_names_refseq": "phosphoribosylglycinamide formyltransferase", "tax_id": 559292, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (sce:YDR408C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;24374639;3889658;8336737;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT40", "ec_number_list": "2.1.2.2", "go_molecular_function": "GO:0004644 phosphoribosylglycinamide formyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0046084 adenine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P04161-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04173-1", "uniprot_id": "LEU3_YEAST", "mass": 38953.0, "length": 364, "protein_name": "3-isopropylmalate dehydrogenase", "gene_name": "LEU2", "organism": "Yeast", "refseq_name": "3-isopropylmalate dehydrogenase", "refseq_ac": "NP_009911", "gene_names_uniprotkb": "LEU2; YCL18W", "gene_names_refseq": "LEU2", "protein_names_uniprotkb": "3-isopropylmalate dehydrogenase; 1.1.1.85; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH", "protein_names_refseq": "3-isopropylmalate dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL018W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1574125;18407956;24374639;3010239;33491328;6330094;6396161", "class_list": "", "function": "Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQZ6", "ec_number_list": "1.1.1.85", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0003862 3-isopropylmalate dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009098 L-leucine biosynthetic process;GO:0006097 glyoxylate cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04449-1", "uniprot_id": "RL24A_YEAST", "mass": 17614.0, "length": 155, "protein_name": "Large ribosomal subunit protein eL24A", "gene_name": "RPL24A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL24 RPL24A", "refseq_ac": "NP_011484", "gene_names_uniprotkb": "RPL24A; RP29; RPL30A", "gene_names_refseq": "RPL24A; RPL30A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL24A; 60S ribosomal protein L24-A; L30; RP29; YL21", "protein_names_refseq": "60S ribosomal protein eL24 RPL24A", "tax_id": 559292, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (sce:YGL031C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 31, "publication_id_list": "11701127;11875433;14562095;14562106;14976550;15665377;17244705;17287358;17330950;17563356;18407956;19779198;19780626;19795423;19823750;20702584;21109664;21177495;22096102;22218487;22814378;23749301;24374639;24524803;30516470;32597660;33481703;33491328;6086628;9169869;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBN7;D6VUA7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006413 translational initiation;GO:0006414 translational elongation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P04449-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04650-1", "uniprot_id": "RL39_YEAST", "mass": 6342.0, "length": 51, "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "RPL39", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL39 RPL39", "refseq_ac": "NP_012346", "gene_names_uniprotkb": "RPL39; J0360; RPL46; SPB2", "gene_names_refseq": "RPL39; RPL46; SPB2", "protein_names_uniprotkb": "Large ribosomal subunit protein eL39; 60S ribosomal protein L39; L46; YL40", "protein_names_refseq": "60S ribosomal protein eL39 RPL39", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL189W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10601260;21109664;22096102;22404850;22814378;24374639;24524803;33491328;4000930;8641269;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW02", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P04650-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04803-1", "uniprot_id": "SYWM_YEAST", "mass": 43015.0, "length": 379, "protein_name": "Tryptophan--tRNA ligase, mitochondrial", "gene_name": "MSW1", "organism": "Yeast", "refseq_name": "tryptophan--tRNA ligase MSW1", "refseq_ac": "NP_010554", "gene_names_uniprotkb": "MSW1; D9954.7; MSW", "gene_names_refseq": "MSW1", "protein_names_uniprotkb": "Tryptophan--tRNA ligase, mitochondrial; 6.1.1.2; TrpRS; Tryptophanyl-tRNA synthetase", "protein_names_refseq": "tryptophan--tRNA ligase MSW1", "tax_id": 559292, "disease": "movement disease (Disease Ontology:DOID:480); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YDR268W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;14576278;1525855;24374639;2999114;9169867", "class_list": "", "function": "Mitochondrial aminoacyl-tRNA synthetase that catalyzes the attachment of tryptophan to tRNA(Trp)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSQ2", "ec_number_list": "6.1.1.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004830 tryptophan-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070183 mitochondrial tryptophanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05085-1", "uniprot_id": "ARGR2_YEAST", "mass": 100282.0, "length": 880, "protein_name": "Arginine metabolism regulation protein II", "gene_name": "ARG81", "organism": "Yeast", "refseq_name": "Arg81p", "refseq_ac": "NP_013610", "gene_names_uniprotkb": "ARG81; ARGR2", "gene_names_refseq": "ARG81; ARGR2", "protein_names_uniprotkb": "Arginine metabolism regulation protein II; Arginine-requiring protein 81", "protein_names_refseq": "Arg81p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML099C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10632874;14562095;18407956;2005902;2005903;2017180;2274024;24374639;3298999;3311884;33491328;3709534;9169872", "class_list": "", "function": "With ARG80, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W0I6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006525 arginine metabolic process;GO:1900081 regulation of arginine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P05085-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05316-1", "uniprot_id": "FUR4_YEAST", "mass": 71736.0, "length": 633, "protein_name": "Uracil permease", "gene_name": "FUR4", "organism": "Yeast", "refseq_name": "uracil permease", "refseq_ac": "NP_009577", "gene_names_uniprotkb": "FUR4; YBR0303", "gene_names_refseq": "FUR4", "protein_names_uniprotkb": "Uracil permease", "protein_names_refseq": "uracil permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR021W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10811641;18407956;19795423;19823750;24374639;32597660;3276521;33481703;33491328;7813418;8091864;9418878", "class_list": "", "function": "Transport of uracil., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ23", "ec_number_list": "", "go_molecular_function": "GO:0015205 nucleobase transmembrane transporter activity;GO:0015505 uracil:monoatomic cation symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole;GO:0032126 eisosome", "go_biological_process": "GO:0015851 nucleobase transport;GO:0055085 transmembrane transport;GO:0015857 uracil transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P05316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05694-1", "uniprot_id": "METE_YEAST", "mass": 85860.0, "length": 767, "protein_name": "5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase", "gene_name": "MET6", "organism": "Yeast", "refseq_name": "5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase", "refseq_ac": "NP_011015", "gene_names_uniprotkb": "MET6", "gene_names_refseq": "MET6", "protein_names_uniprotkb": "5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; 2.1.1.14; Cobalamin-independent methionine synthase; Delta-P8 protein; Methionine synthase, vitamin-B12 independent isozyme", "protein_names_refseq": "5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER091C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;17330950;18407956;19779198;20702584;21177495;22814378;23749301;24374639;32597660;33481703;33491328;34965436;7483834;7895733;8935650;9169868", "class_list": "", "function": "Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLZ8;P38010;Q02488;Q27JJ8", "ec_number_list": "2.1.1.14", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0032259 methylation;GO:0009086 methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P05694-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05738-1", "uniprot_id": "RL9A_YEAST", "mass": 21569.0, "length": 191, "protein_name": "Large ribosomal subunit protein uL6A", "gene_name": "RPL9A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL6 RPL9A", "refseq_ac": "NP_011368", "gene_names_uniprotkb": "RPL9A; RPL8A; RPL9", "gene_names_refseq": "RPL9A", "protein_names_uniprotkb": "Large ribosomal subunit protein uL6A; 60S ribosomal protein L9-A; L8; RP24; YL11", "protein_names_refseq": "60S ribosomal protein uL6 RPL9A", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL147C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11701127;14562095;14562106;14976550;18782943;1945856;19779198;21109664;22096102;23749301;24374639;24524803;33491328;9046099;9169869;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU02", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P05738-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05743-1", "uniprot_id": "RL26A_YEAST", "mass": 14234.0, "length": 127, "protein_name": "Large ribosomal subunit protein uL24A", "gene_name": "RPL26A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL24 RPL26A", "refseq_ac": "NP_013448", "gene_names_uniprotkb": "RPL26A; L8300.4; RPL26; RPL33A", "gene_names_refseq": "RPL26A", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24A; 60S ribosomal protein L26-A; L33; YL33", "protein_names_refseq": "60S ribosomal protein uL24 RPL26A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 11 (Disease Ontology:DOID:0111892)", "pathway": " (sce:YLR344W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "11701127;14562095;14976550;18782943;21109664;21126336;22096102;24374639;24524803;32597660;33481703;33491328;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYY3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P05743-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05747-1", "uniprot_id": "RL29_YEAST", "mass": 6669.0, "length": 59, "protein_name": "Large ribosomal subunit protein eL29", "gene_name": "RPL29", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL29 RPL29", "refseq_ac": "NP_116690", "gene_names_uniprotkb": "RPL29; YFR032BW; YL43", "gene_names_refseq": "RPL29", "protein_names_uniprotkb": "Large ribosomal subunit protein eL29; 60S ribosomal protein L29; YL43", "protein_names_refseq": "60S ribosomal protein eL29 RPL29", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR032C-A); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 15, "publication_id_list": "10601260;14562095;14562106;17244705;17322287;18782943;21109664;22096102;22106047;22814378;24374639;24524803;33491328;7670463;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBN8;D6VTR4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P05747-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05749-1", "uniprot_id": "RL22A_YEAST", "mass": 13693.0, "length": 121, "protein_name": "Large ribosomal subunit protein eL22A", "gene_name": "RPL22A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL22 RPL22A", "refseq_ac": "NP_013162", "gene_names_uniprotkb": "RPL22A; L2168", "gene_names_refseq": "RPL22A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL22A; 60S ribosomal protein L22-A; L1c; RP4; YL31", "protein_names_refseq": "60S ribosomal protein eL22 RPL22A", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR061W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10601260;14562095;14562106;18407956;21109664;21126336;22096102;23749301;24374639;24524803;33491328;6814480;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY63", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P05749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06182-1", "uniprot_id": "CCHL_YEAST", "mass": 30081.0, "length": 269, "protein_name": "Holocytochrome-c synthase", "gene_name": "CYC3", "organism": "Yeast", "refseq_name": "holocytochrome c synthase CYC3", "refseq_ac": "NP_009361", "gene_names_uniprotkb": "CYC3", "gene_names_refseq": "CYC3", "protein_names_uniprotkb": "Holocytochrome-c synthase; 4.4.1.17; CCHL; Cytochrome c heme lyase", "protein_names_refseq": "holocytochrome c synthase CYC3", "tax_id": 559292, "disease": "linear skin defects with multiple congenital anomalies 1 (Disease Ontology:DOID:0111808); microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (sce:YAL039C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;22984289;24374639;3034577;33481703;33491328;7731988", "class_list": "", "function": "Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH7", "ec_number_list": "4.4.1.17", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004408 holocytochrome-c synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0018063 cytochrome c-heme linkage", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P06182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06633-1", "uniprot_id": "HIS7_YEAST", "mass": 23833.0, "length": 220, "protein_name": "Imidazoleglycerol-phosphate dehydratase", "gene_name": "HIS3", "organism": "Yeast", "refseq_name": "imidazoleglycerol-phosphate dehydratase HIS3", "refseq_ac": "NP_014845", "gene_names_uniprotkb": "HIS3", "gene_names_refseq": "HIS10; HIS3; HIS8", "protein_names_uniprotkb": "Imidazoleglycerol-phosphate dehydratase; 4.2.1.19; IGPD", "protein_names_refseq": "imidazoleglycerol-phosphate dehydratase HIS3", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR202W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;15087486;24374639;29434040;3001645;33491328;3532321;6173490;9169874", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q9;Q12695;Q70D78;Q70D79;Q70D81;Q70D83", "ec_number_list": "4.2.1.19", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004424 imidazoleglycerol-phosphate dehydratase activity", "go_cellular_component": "", "go_biological_process": "GO:0000105 L-histidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P06633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06773-1", "uniprot_id": "DCTD_YEAST", "mass": 35646.0, "length": 312, "protein_name": "Deoxycytidylate deaminase", "gene_name": "DCD1", "organism": "Yeast", "refseq_name": "deoxycytidine monophosphate deaminase", "refseq_ac": "NP_012014", "gene_names_uniprotkb": "DCD1", "gene_names_refseq": "DCD1", "protein_names_uniprotkb": "Deoxycytidylate deaminase; 3.5.4.12; dCMP deaminase", "protein_names_refseq": "deoxycytidine monophosphate deaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR144C); (R-SCE-499943)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14562106;24374639;3023902;32597660;33491328;8091229", "class_list": "", "function": "Catalyzes the hydrolytic deamination of dCMP to yield dUMP, the nucleotide substrate for thymidylate synthetase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL94", "ec_number_list": "3.5.4.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004132 dCMP deaminase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06775-1", "uniprot_id": "HIP1_YEAST", "mass": 66006.0, "length": 603, "protein_name": "Histidine permease", "gene_name": "HIP1", "organism": "Yeast", "refseq_name": "histidine permease", "refseq_ac": "NP_011707", "gene_names_uniprotkb": "HIP1; G7572", "gene_names_refseq": "HIP1", "protein_names_uniprotkb": "Histidine permease", "protein_names_refseq": "histidine permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR191W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;15665377;16847258;17330950;19779198;23749301;24374639;32597660;33481703;33491328;34965436;3905514;7645350;9169869", "class_list": "", "function": "High-affinity permease for histidine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUX3", "ec_number_list": "", "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0005291 high-affinity L-histidine transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0003333 amino acid transmembrane transport;GO:0015817 histidine transport;GO:0006828 manganese ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P06775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06776-1", "uniprot_id": "PDE2_YEAST", "mass": 61000.0, "length": 526, "protein_name": "3',5'-cyclic-nucleotide phosphodiesterase 2", "gene_name": "PDE2", "organism": "Yeast", "refseq_name": "3',5'-cyclic-nucleotide phosphodiesterase PDE2", "refseq_ac": "NP_015005", "gene_names_uniprotkb": "PDE2; SRA5", "gene_names_refseq": "PDE2; SRA5", "protein_names_uniprotkb": "3',5'-cyclic-nucleotide phosphodiesterase 2; 3.1.4.53; High-affinity cAMP phosphodiesterase; PDEase 2", "protein_names_refseq": "3',5'-cyclic-nucleotide phosphodiesterase PDE2", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stroke (Disease Ontology:DOID:0051061); primary pigmented nodular adrenocortical disease 3 (Disease Ontology:DOID:0070548); Parkinsonism (Disease Ontology:DOID:0080855); autosomal dominant nonsyndromic deafness 74 (Disease Ontology:DOID:0112165); brucellosis (Disease Ontology:DOID:11077); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); acrodysostosis (Disease Ontology:DOID:14669); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congestive heart failure (Disease Ontology:DOID:6000); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YOR360C); (R-SCE-165160); (R-SCE-418555)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14562106;24374639;3025832;33491328;9169874", "class_list": "", "function": "Controls the level of cAMP in yeast cells, together with the low-affinity cAMP phosphodiesterase (PDE1)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W355;Q08836", "ec_number_list": "3.1.4.53", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P06776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07258-1", "uniprot_id": "CARA_YEAST", "mass": 45362.0, "length": 411, "protein_name": "Carbamoyl phosphate synthase arginine-specific small chain", "gene_name": "CPA1", "organism": "Yeast", "refseq_name": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1", "refseq_ac": "NP_014947", "gene_names_uniprotkb": "CPA1", "gene_names_refseq": "CPA1", "protein_names_uniprotkb": "Carbamoyl phosphate synthase arginine-specific small chain; 6.3.5.5; Arginine-specific carbamoyl phosphate synthetase, glutamine chain; CPS-A; CPSase-arg; CPSase; CPS; Carbamoyl phosphate synthase A; Glutamine-dependent carbamoyl phosphate synthetase", "protein_names_refseq": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR303W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10608810;14562095;14562106;200419;205532;206535;206652;24374639;33481703;33491328;3555844;3881260;4594376;5856369;6086650;9153758;9169874;9290206", "class_list": "", "function": "Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W302", "ec_number_list": "6.3.4.16;6.3.5.5;2.1.3.2;3.5.1.2;4.3.2.10;4.3.3.6", "go_molecular_function": "GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0005524 ATP binding;GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:0005951 carbamoyl-phosphate synthase complex", "go_biological_process": "GO:0006526 L-arginine biosynthetic process;GO:0006541 glutamine metabolic process;GO:0006221 pyrimidine nucleotide biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P07258-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07262-1", "uniprot_id": "DHE4_YEAST", "mass": 49570.0, "length": 454, "protein_name": "NADP-specific glutamate dehydrogenase 1", "gene_name": "GDH1", "organism": "Yeast", "refseq_name": "glutamate dehydrogenase (NADP(+)) GDH1", "refseq_ac": "NP_015020", "gene_names_uniprotkb": "GDH1; DHE4; URE1", "gene_names_refseq": "DHE4; GDH1; URE1", "protein_names_uniprotkb": "NADP-specific glutamate dehydrogenase 1; 1.4.1.4; NADP-GDH 1; NADP-dependent glutamate dehydrogenase 1", "protein_names_refseq": "glutamate dehydrogenase (NADP(+)) GDH1", "tax_id": 559292, "disease": "familial hyperinsulinemic hypoglycemia 6 (Disease Ontology:DOID:0070217); Alzheimer's disease (Disease Ontology:DOID:10652); hepatic encephalopathy (Disease Ontology:DOID:13413); childhood absence epilepsy (Disease Ontology:DOID:1825); hyperinsulinism (Disease Ontology:DOID:2018); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); fascioliasis (Disease Ontology:DOID:885); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YOR375C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12872131;14562106;19795423;19823750;22106047;22814378;24374639;2932370;2989290;33481703;33491328;8935650;9169874", "class_list": "", "function": "Catalyzes the incorporation of an ammonium ion into alpha-ketoglutarate to form L-glutamate, the major route of assimilation of ammonia into an organic form in yeast., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W368;Q08899", "ec_number_list": "1.4.1.4", "go_molecular_function": "GO:0004354 glutamate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07266-1", "uniprot_id": "MRS1_YEAST", "mass": 41290.0, "length": 363, "protein_name": "Mitochondrial RNA-splicing protein MRS1", "gene_name": "MRS1", "organism": "Yeast", "refseq_name": "Mrs1p", "refseq_ac": "NP_012287", "gene_names_uniprotkb": "MRS1; PET157", "gene_names_refseq": "MRS1; PET157", "protein_names_uniprotkb": "Mitochondrial RNA-splicing protein MRS1", "protein_names_refseq": "Mrs1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR021W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11773622;14562095;14562106;14576278;1699677;24374639;2443348;33491328;9169870", "class_list": "", "function": "Function in mitochondrial RNA splicing in the excision of mitochondrial group I introns aI5 beta from COX1 and bI3 from COB transcripts and thus would be involved in obtaining the correct structure of the intron, to allow the RNA catalyzed reactions to occur., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVV1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004520 DNA endonuclease activity;GO:0000403 Y-form DNA binding;GO:0070336 flap-structured DNA binding;GO:0000402 crossed form four-way junction DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000963 mitochondrial RNA processing;GO:0006397 mRNA processing;GO:0000372 Group I intron splicing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07272-1", "uniprot_id": "PPR1_YEAST", "mass": 102724.0, "length": 904, "protein_name": "Pyrimidine pathway regulatory protein 1", "gene_name": "PPR1", "organism": "Yeast", "refseq_name": "Ppr1p", "refseq_ac": "NP_013114", "gene_names_uniprotkb": "PPR1", "gene_names_refseq": "PPR1", "protein_names_uniprotkb": "Pyrimidine pathway regulatory protein 1", "protein_names_refseq": "Ppr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR014C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "18407956;19779198;23749301;24374639;32597660;33481703;33491328;6096561;7958913;9169871", "class_list": "", "function": "Positive regulator of URA1 and URA3 expression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY16", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006221 pyrimidine nucleotide biosynthetic process;GO:1900399 positive regulation of pyrimidine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P07272-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07275-1", "uniprot_id": "PUT2_YEAST", "mass": 64435.0, "length": 575, "protein_name": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "gene_name": "PUT2", "organism": "Yeast", "refseq_name": "1-pyrroline-5-carboxylate dehydrogenase", "refseq_ac": "NP_011902", "gene_names_uniprotkb": "PUT2", "gene_names_refseq": "PUT2", "protein_names_uniprotkb": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; 1.2.1.88; L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase", "protein_names_refseq": "1-pyrroline-5-carboxylate dehydrogenase", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hyperprolinemia type 2 (Disease Ontology:DOID:0080543)", "pathway": " (sce:YHR037W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11502169;14562106;24374639;3062363;33481703;33491328;6098824;8091229", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKY4", "ec_number_list": "1.2.1.88", "go_molecular_function": "GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07275-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07284-1", "uniprot_id": "SYSC_YEAST", "mass": 53310.0, "length": 462, "protein_name": "Serine--tRNA ligase, cytoplasmic", "gene_name": "SES1", "organism": "Yeast", "refseq_name": "serine--tRNA ligase SES1", "refseq_ac": "NP_010306", "gene_names_uniprotkb": "SES1; SERS; YD9813.01", "gene_names_refseq": "SES1", "protein_names_uniprotkb": "Serine--tRNA ligase, cytoplasmic; 6.1.1.11; SerRS; Seryl-tRNA synthetase; Seryl-tRNA(Ser) synthetase", "protein_names_refseq": "serine--tRNA ligase SES1", "tax_id": 559292, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate carcinoma (Disease Ontology:DOID:10286); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (sce:YDR023W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18407956;22814378;24374639;28003514;3031581;30516470;30742068;33481703;33491328;36102610;8070651;8896275;9169867", "class_list": "", "function": "Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS09", "ec_number_list": "6.1.1.11", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004828 serine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006434 seryl-tRNA aminoacylation;GO:0110004 positive regulation of tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07806-1", "uniprot_id": "SYV_YEAST", "mass": 125770.0, "length": 1104, "protein_name": "Valine--tRNA ligase, mitochondrial", "gene_name": "VAS1", "organism": "Yeast", "refseq_name": "valine--tRNA ligase", "refseq_ac": "NP_011608", "gene_names_uniprotkb": "VAS1", "gene_names_refseq": "VAS1", "protein_names_uniprotkb": "Valine--tRNA ligase, mitochondrial; 6.1.1.9; ValRS; Valyl-tRNA synthetase", "protein_names_refseq": "valine--tRNA ligase", "tax_id": 559292, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined oxidative phosphorylation deficiency 20 (Disease Ontology:DOID:0111478); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (sce:YGR094W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;18407956;23749301;24374639;28270554;32597660;3275649;3294828;33481703;33491328;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUM6", "ec_number_list": "6.1.1.9", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:1990825 sequence-specific mRNA binding;GO:0004832 valine-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006438 valyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P07806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07807-1", "uniprot_id": "DYR_YEAST", "mass": 24261.0, "length": 211, "protein_name": "Dihydrofolate reductase", "gene_name": "DFR1", "organism": "Yeast", "refseq_name": "dihydrofolate reductase", "refseq_ac": "NP_014879", "gene_names_uniprotkb": "DFR1; O5231", "gene_names_refseq": "DFR1", "protein_names_uniprotkb": "Dihydrofolate reductase; 1.5.1.3", "protein_names_refseq": "dihydrofolate reductase", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YOR236W); (R-SCE-196757)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562106;24374639;2827121;2838385;2838386;8972580;9169874", "class_list": "", "function": "Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2T9", "ec_number_list": "1.5.1.3", "go_molecular_function": "GO:0004146 dihydrofolate reductase activity;GO:0003729 mRNA binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0006730 one-carbon metabolic process;GO:0046655 folic acid metabolic process;GO:0046452 dihydrofolate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P07807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08431-1", "uniprot_id": "GAL7_YEAST", "mass": 42385.0, "length": 366, "protein_name": "Galactose-1-phosphate uridylyltransferase", "gene_name": "GAL7", "organism": "Yeast", "refseq_name": "UDP-glucose:hexose-1-phosphate uridylyltransferase", "refseq_ac": "NP_009574", "gene_names_uniprotkb": "GAL7; YBR0226", "gene_names_refseq": "GAL7", "protein_names_uniprotkb": "Galactose-1-phosphate uridylyltransferase; 2.7.7.12; Gal-1-P uridylyltransferase; UDP-glucose--hexose-1-phosphate uridylyltransferase", "protein_names_refseq": "UDP-glucose:hexose-1-phosphate uridylyltransferase", "tax_id": 559292, "disease": "classic galactosemia (Disease Ontology:DOID:0111459); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (sce:YBR018C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19779198;22814378;24374639;2851900;6324089;6715281;7762304;7813418", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ20;P04398", "ec_number_list": "2.7.7.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08456-1", "uniprot_id": "PSS_YEAST", "mass": 30805.0, "length": 276, "protein_name": "CDP-diacylglycerol--serine O-phosphatidyltransferase", "gene_name": "CHO1", "organism": "Yeast", "refseq_name": "CDP-diacylglycerol-serine O-phosphatidyltransferase", "refseq_ac": "NP_010943", "gene_names_uniprotkb": "CHO1; PSS1", "gene_names_refseq": "CHO1; PSS1", "protein_names_uniprotkb": "CDP-diacylglycerol--serine O-phosphatidyltransferase; 2.7.8.8; PSS; Phosphatidylserine synthase", "protein_names_refseq": "CDP-diacylglycerol-serine O-phosphatidyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER026C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11875433;15665377;17330950;17563356;18407956;19684113;19779198;20145252;20702584;21126336;21177495;22218487;23749301;24374639;2830250;3005242;3040403;30516470;32597660;33481703;33491328;6088519;6274497;9169868", "class_list": "", "function": "Catalyzes the synthesis of phosphatidylserine (PtdSer)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS5", "ec_number_list": "2.7.8.8", "go_molecular_function": "GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P08456-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08465-1", "uniprot_id": "MET2_YEAST", "mass": 53659.0, "length": 486, "protein_name": "Homoserine O-acetyltransferase", "gene_name": "MET2", "organism": "Yeast", "refseq_name": "homoserine O-acetyltransferase", "refseq_ac": "NP_014122", "gene_names_uniprotkb": "MET2; N0615", "gene_names_refseq": "MET2", "protein_names_uniprotkb": "Homoserine O-acetyltransferase; 2.3.1.31; Homoserine O-trans-acetylase", "protein_names_refseq": "homoserine O-acetyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL277W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11914276;14562095;14562106;19779198;20702584;24374639;33481703;33491328;3552887;9169873", "class_list": "", "function": "Commits homoserine to the methionine biosynthesis pathway by catalyzing its O-acetylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0R8", "ec_number_list": "2.3.1.31", "go_molecular_function": "GO:0004414 homoserine O-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009086 methionine biosynthetic process;GO:0000096 sulfur amino acid metabolic process;GO:0009092 homoserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08465-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09368-1", "uniprot_id": "PUT1_YEAST", "mass": 53271.0, "length": 476, "protein_name": "Proline dehydrogenase, mitochondrial", "gene_name": "PUT1", "organism": "Yeast", "refseq_name": "proline dehydrogenase", "refseq_ac": "NP_013243", "gene_names_uniprotkb": "PUT1; L3170; L9606.2", "gene_names_refseq": "PUT1", "protein_names_uniprotkb": "Proline dehydrogenase, mitochondrial; 1.5.5.2; Proline oxidase", "protein_names_refseq": "proline dehydrogenase", "tax_id": 559292, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); schizophrenia 4 (Disease Ontology:DOID:0070080); hyperprolinemia type 1 (Disease Ontology:DOID:0080542); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YLR142W); (R-SCE-389661); (R-SCE-70688)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14562106;17322287;21177495;24374639;3125423;33491328;9169871", "class_list": "", "function": "Converts proline to delta-1-pyrroline-5-carboxylate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYD6", "ec_number_list": "1.5.5.2", "go_molecular_function": "GO:0071949 FAD binding;GO:0004657 proline dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09435-1", "uniprot_id": "HSP73_YEAST", "mass": 70547.0, "length": 649, "protein_name": "Heat shock protein SSA3", "gene_name": "SSA3", "organism": "Yeast", "refseq_name": "Hsp70 family ATPase SSA3", "refseq_ac": "NP_009478", "gene_names_uniprotkb": "SSA3; YBL06.07; YBL0610", "gene_names_refseq": "SSA3; YG106", "protein_names_uniprotkb": "Heat shock protein SSA3", "protein_names_refseq": "Hsp70 family ATPase SSA3", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); lymphoma (Disease Ontology:DOID:0060058); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); paranoid schizophrenia (Disease Ontology:DOID:1229); vitiligo (Disease Ontology:DOID:12306); cardiovascular system disease (Disease Ontology:DOID:1287); uveitis (Disease Ontology:DOID:13141); Kawasaki disease (Disease Ontology:DOID:13378); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); systolic heart failure (Disease Ontology:DOID:9651); senile cataract (Disease Ontology:DOID:9669); Meniere's disease (Disease Ontology:DOID:9849); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YBL075C); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "14562106;18407956;1922071;2188113;24374639;2663194;33481703;33491328;7813418;7992509;8151709", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 44, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPS7;P18862", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006457 protein folding;GO:0042026 protein refolding;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P09435-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09457-1", "uniprot_id": "ATPO_YEAST", "mass": 22814.0, "length": 212, "protein_name": "ATP synthase subunit 5, mitochondrial", "gene_name": "ATP5", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit 5", "refseq_ac": "NP_010584", "gene_names_uniprotkb": "ATP5; D9740.11; OSCP", "gene_names_refseq": "ATP5; OSC1", "protein_names_uniprotkb": "ATP synthase subunit 5, mitochondrial; ATP synthase chain 5; OSCP; Oligomycin sensitivity conferral protein", "protein_names_refseq": "F1F0 ATP synthase subunit 5", "tax_id": 559292, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 7 (Disease Ontology:DOID:0070464); Alzheimer's disease (Disease Ontology:DOID:10652); hypothyroidism (Disease Ontology:DOID:1459); Leigh disease (Disease Ontology:DOID:3652); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (sce:YDR298C); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;17322287;17761666;19795423;19823750;2146269;23749301;24374639;2971156;9169867", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS7", "ec_number_list": "", "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P09457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0W1-1", "uniprot_id": "RS22A_YEAST", "mass": 14626.0, "length": 130, "protein_name": "Small ribosomal subunit protein uS8A", "gene_name": "RPS22A", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS8 RPS22A", "refseq_ac": "NP_012345", "gene_names_uniprotkb": "RPS22A; J0355; RPS24A; RPS24", "gene_names_refseq": "RPS22A; RPS24", "protein_names_uniprotkb": "Small ribosomal subunit protein uS8A; 40S ribosomal protein S22-A; RP50; S24; YP58; YS22", "protein_names_refseq": "40S ribosomal protein uS8 RPS22A", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 20 (Disease Ontology:DOID:0111891)", "pathway": " (sce:YJL190C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 15, "publication_id_list": "10601260;11701127;14562106;14976550;19795423;19823750;21109664;22096102;24374639;24524803;4000930;6814480;7754713;8641269;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW01;P04648", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P0C0W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2H6-1", "uniprot_id": "RL27A_YEAST", "mass": 15531.0, "length": 136, "protein_name": "Large ribosomal subunit protein eL27A", "gene_name": "RPL27A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL27 RPL27A", "refseq_ac": "NP_011874", "gene_names_uniprotkb": "RPL27A; RPL27", "gene_names_refseq": "RPL27A; RPL27", "protein_names_uniprotkb": "Large ribosomal subunit protein eL27A; 60S ribosomal protein L27-A", "protein_names_refseq": "60S ribosomal protein eL27 RPL27A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 16 (Disease Ontology:DOID:0111893)", "pathway": " (sce:YHR010W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 13, "publication_id_list": "10601260;14562095;14562106;19795423;19823750;21109664;22096102;24374639;24524803;32597660;33481703;8091229;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV5;P38706", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P0C2H6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2H8-1", "uniprot_id": "RL31A_YEAST", "mass": 12953.0, "length": 113, "protein_name": "Large ribosomal subunit protein eL31A", "gene_name": "RPL31A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL31 RPL31A", "refseq_ac": "NP_010208", "gene_names_uniprotkb": "RPL31A; D2478; RPL34A; RPL34", "gene_names_refseq": "RPL31A; RPL34", "protein_names_uniprotkb": "Large ribosomal subunit protein eL31A; 60S ribosomal protein L31-A; L34; YL28", "protein_names_refseq": "60S ribosomal protein eL31 RPL31A", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL075W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10601260;11701127;14976550;17563356;18782943;19795423;19823750;21109664;22096102;24374639;24524803;32597660;33481703;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRS4;P04649;Q3E7B8", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P0C2H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C2H9-1", "uniprot_id": "RL31B_YEAST", "mass": 12967.0, "length": 113, "protein_name": "Large ribosomal subunit protein eL31B", "gene_name": "RPL31B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL31 RPL31B", "refseq_ac": "NP_013510", "gene_names_uniprotkb": "RPL31B; RPL34B; RPL34", "gene_names_refseq": "RPL31B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL31B; 60S ribosomal protein L31-B; L34; YL28", "protein_names_refseq": "60S ribosomal protein eL31 RPL31B", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR406C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "14562095;14562106;17287358;22096102;24374639;24524803;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ39;P04649;Q3E7B8", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P0C2H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CD90-1", "uniprot_id": "AQY2_YEAST", "mass": 17024.0, "length": 149, "protein_name": "Aquaporin-like protein 2", "gene_name": "AQY2", "organism": "Yeast", "refseq_name": "Aqy2p", "refseq_ac": "NP_013048", "gene_names_uniprotkb": "AQY2; AQY2-2; L0590", "gene_names_refseq": "AQY2", "protein_names_uniprotkb": "Aquaporin-like protein 2; Truncated aquaporin-2", "protein_names_refseq": "Aqy2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL052C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10870101;11158584;14562095;24374639;9169871", "class_list": "", "function": "Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance, osmotolerance and cell flocculation in liquid cultures (By similarity). Is non-functional in most laboratory strains., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXV6;O93938;Q12258;Q12302;Q9C411", "ec_number_list": "", "go_molecular_function": "GO:0015250 water channel activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0CD90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CD99-1", "uniprot_id": "MPH2_YEAST", "mass": 68189.0, "length": 609, "protein_name": "Alpha-glucosides permease MPH2", "gene_name": "MPH2", "organism": "Yeast", "refseq_name": "alpha-glucoside permease", "refseq_ac": "NP_010034", "gene_names_uniprotkb": "MPH2", "gene_names_refseq": "MPH2", "protein_names_uniprotkb": "Alpha-glucosides permease MPH2; Maltose transport protein 2", "protein_names_refseq": "alpha-glucoside permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL247W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10618490;12210897;24374639;9169867", "class_list": "", "function": "High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRB0;P47186;Q07787", "ec_number_list": "", "go_molecular_function": "GO:0005351 carbohydrate:proton symporter activity;GO:0015151 alpha-glucoside transmembrane transporter activity;GO:0005363 maltose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0055085 transmembrane transport;GO:0008643 carbohydrate transport;GO:0000023 maltose metabolic process;GO:0000017 alpha-glucoside transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0CD99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CE00-1", "uniprot_id": "MPH3_YEAST", "mass": 67257.0, "length": 602, "protein_name": "Alpha-glucosides permease MPH3", "gene_name": "MPH3", "organism": "Yeast", "refseq_name": "alpha-glucoside permease", "refseq_ac": "NP_012694", "gene_names_uniprotkb": "MPH3; J2400", "gene_names_refseq": "MPH3", "protein_names_uniprotkb": "Alpha-glucosides permease MPH3; Maltose transport protein 3", "protein_names_refseq": "alpha-glucoside permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR160C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10618490;12210897;16847258;24374639;8641269", "class_list": "", "function": "High-affinity uptake of maltose and maltotriose. Also transports alpha-methylglucoside, glucose and turanose but not melezitose or trehalose., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWX8;P47186;Q07787", "ec_number_list": "", "go_molecular_function": "GO:0005351 carbohydrate:proton symporter activity;GO:0015151 alpha-glucoside transmembrane transporter activity;GO:0005363 maltose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0000023 maltose metabolic process;GO:0000017 alpha-glucoside transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0CE00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CE68-1", "uniprot_id": "NFT1_YEAST", "mass": 137997.0, "length": 1218, "protein_name": "ABC transporter NFT1", "gene_name": "NFT1", "organism": "Yeast", "refseq_name": "putative multidrug transporter NFT1", "refseq_ac": "NP_013029", "gene_names_uniprotkb": "NFT1", "gene_names_refseq": "NFT1", "protein_names_uniprotkb": "ABC transporter NFT1; New full-length MRP-type transporter 1", "protein_names_refseq": "putative multidrug transporter NFT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR103W); (R-SCE-382556); (R-SCE-8856825)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21177495;24374639;8196765", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VXG4;P36028;P36171;Q53ZY4;Q6Q5L3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CE68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CH63-1", "uniprot_id": "DDI2_YEAST", "mass": 25152.0, "length": 225, "protein_name": "Cyanamide hydratase DDI2", "gene_name": "DDI2", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DDI2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyanamide hydratase DDI2; 4.2.1.69; CAH; DNA damage-inducible protein 2", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL061W); (sce:YNL335W)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17322287;18485869;24374639;25847245;7670463", "class_list": "", "function": "Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTG9;P43543", "ec_number_list": "4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0018820 cyanamide hydratase activity", "go_cellular_component": "", "go_biological_process": "GO:0018890 cyanamide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0CH63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CH64-1", "uniprot_id": "DDI3_YEAST", "mass": 25152.0, "length": 225, "protein_name": "Cyanamide hydratase DDI3", "gene_name": "DDI3", "organism": "Yeast", "refseq_name": "cyanamide hydratase", "refseq_ac": "NP_014064", "gene_names_uniprotkb": "DDI3; N0280", "gene_names_refseq": "DDI2; DDI3", "protein_names_uniprotkb": "Cyanamide hydratase DDI3; 4.2.1.69; CAH; DNA damage-inducible protein 3", "protein_names_refseq": "cyanamide hydratase", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL061W); (sce:YNL335W)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17322287;18485869;24374639;25847245;9169873", "class_list": "", "function": "Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTG9;P43543", "ec_number_list": "4.2.1.69", "go_molecular_function": "GO:0018820 cyanamide hydratase activity", "go_cellular_component": "", "go_biological_process": "GO:0018890 cyanamide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0CH64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CW40-1", "uniprot_id": "MALX2_YEAST", "mass": 68699.0, "length": 589, "protein_name": "Oligo-1,6-glucosidase IMA3", "gene_name": "IMA3", "organism": "Yeast", "refseq_name": "oligo-1,6-glucosidase IMA3", "refseq_ac": "NP_012096", "gene_names_uniprotkb": "IMA3", "gene_names_refseq": "IMA3", "protein_names_uniprotkb": "Oligo-1,6-glucosidase IMA3; 3.2.1.10; Alpha-glucosidase; Isomaltase 3", "protein_names_refseq": "oligo-1,6-glucosidase IMA3", "tax_id": 559292, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (sce:YIL172C); (sce:YJL221C); (R-SCE-352230)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14562095;14562106;20562106;24374639;9169870", "class_list": "", "function": "Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides. Not required for isomaltose utilization, but overexpression allows the IMA1 null mutant to grow on isomaltose., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVX6;P40439", "ec_number_list": "3.2.1.10", "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0004556 alpha-amylase activity;GO:0004574 oligo-1,6-glucosidase activity;GO:0004575 sucrose alpha-glucosidase activity;GO:0033934 glucan 1,4-alpha-maltotriohydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000025 maltose catabolic process;GO:0005987 sucrose catabolic process;GO:0046352 disaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0CW40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX08-1", "uniprot_id": "DSF1_YEAST", "mass": 56470.0, "length": 502, "protein_name": "Mannitol dehydrogenase DSF1", "gene_name": "DSF1", "organism": "Yeast", "refseq_name": "mannitol dehydrogenase DSF1", "refseq_ac": "NP_010844", "gene_names_uniprotkb": "DSF1; MAN1", "gene_names_refseq": "DSF1; MAN1", "protein_names_uniprotkb": "Mannitol dehydrogenase DSF1; 1.1.1.67; Deletion suppressor of MPT5 mutation protein 1", "protein_names_refseq": "mannitol dehydrogenase DSF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL070W); (sce:YNR073C)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14562106;16328373;24374639;26996892;33491328;9169868", "class_list": "", "function": "Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLI1;P39941", "ec_number_list": "1.1.1.67", "go_molecular_function": "GO:0046029 mannitol dehydrogenase activity;GO:0050086 mannitol 2-dehydrogenase activity", "go_cellular_component": "", "go_biological_process": "GO:0019594 mannitol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0CX08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX14-1", "uniprot_id": "YRF13_YEAST", "mass": 211115.0, "length": 1859, "protein_name": "Y' element ATP-dependent helicase protein 1 copy 3", "gene_name": "YRF1-3", "organism": "Yeast", "refseq_name": "Y' element ATP-dependent helicase protein 1 copy 3", "refseq_ac": "NP_011812", "gene_names_uniprotkb": "YRF1-3", "gene_names_refseq": "YRF1-3; YRF1", "protein_names_uniprotkb": "Y' element ATP-dependent helicase protein 1 copy 3; 5.6.2.-", "protein_names_refseq": "Y' element ATP-dependent helicase protein 1 copy 3", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR296W); (sce:YPL283C)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "24374639;9169869;9837911", "class_list": "", "function": "Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV70;P53345;Q9UQW1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CX14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX15-1", "uniprot_id": "YRF17_YEAST", "mass": 211115.0, "length": 1859, "protein_name": "Y' element ATP-dependent helicase protein 1 copy 7", "gene_name": "YRF1-7", "organism": "Yeast", "refseq_name": "Y' element ATP-dependent helicase protein 1 copy 7", "refseq_ac": "NP_015040", "gene_names_uniprotkb": "YRF1-7", "gene_names_refseq": "YRF1-7; YRF1", "protein_names_uniprotkb": "Y' element ATP-dependent helicase protein 1 copy 7; 5.6.2.-", "protein_names_refseq": "Y' element ATP-dependent helicase protein 1 copy 7", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR296W); (sce:YPL283C)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "24374639;9169875;9837911", "class_list": "", "function": "Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV70;P53345;Q9UQW1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CX15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX20-1", "uniprot_id": "YRF11_YEAST", "mass": 203781.0, "length": 1796, "protein_name": "Y' element ATP-dependent helicase protein 1 copy 1", "gene_name": "YRF1-1", "organism": "Yeast", "refseq_name": "Y' element ATP-dependent helicase protein 1 copy 1", "refseq_ac": "NP_010834", "gene_names_uniprotkb": "YRF1-1; D3703.4", "gene_names_refseq": "YRF1-1; YRF1", "protein_names_uniprotkb": "Y' element ATP-dependent helicase protein 1 copy 1; 5.6.2.-", "protein_names_refseq": "Y' element ATP-dependent helicase protein 1 copy 1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR545W); (sce:YLR467W); (sce:YOR396W)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19779198;24374639;9169867;9837911", "class_list": "", "function": "Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTG2;O94087;P24088;P24089;Q53WX0;Q99313", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0CX20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX21-1", "uniprot_id": "YRF15_YEAST", "mass": 203781.0, "length": 1796, "protein_name": "Y' element ATP-dependent helicase protein 1 copy 5", "gene_name": "YRF1-5", "organism": "Yeast", "refseq_name": "Y' element ATP-dependent helicase protein 1 copy 5", "refseq_ac": "NP_013572", "gene_names_uniprotkb": "YRF1-5; L9040", "gene_names_refseq": "YRF1-5; YRF1", "protein_names_uniprotkb": "Y' element ATP-dependent helicase protein 1 copy 5; 5.6.2.-", "protein_names_refseq": "Y' element ATP-dependent helicase protein 1 copy 5", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR545W); (sce:YLR467W); (sce:YOR396W)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "24374639;9169871;9837911", "class_list": "", "function": "Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTG2;O94087;P24088;P24089;Q53WX0;Q99313", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CX21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX23-1", "uniprot_id": "RL20A_YEAST", "mass": 20437.0, "length": 172, "protein_name": "Large ribosomal subunit protein eL20A", "gene_name": "RPL20A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL20 RPL20A", "refseq_ac": "NP_013969", "gene_names_uniprotkb": "RPL20A; RPL18A2; RPL18A; YM9408.04C", "gene_names_refseq": "RPL18A2; RPL20A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL20A; 60S ribosomal protein L20-A; L18a", "protein_names_refseq": "60S ribosomal protein eL20 RPL20A", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (sce:YMR242C); (sce:YOR312C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 10, "publication_count": 16, "publication_id_list": "14562095;14562106;17101987;17287358;17351133;21109664;22096102;22106047;22814378;23749301;24374639;24524803;30516470;32597660;9169872;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1YV95;A1YV96;D6W068;P0C2I0;P0C2I1;P47913", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P0CX23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX25-1", "uniprot_id": "RL43A_YEAST", "mass": 10091.0, "length": 92, "protein_name": "Large ribosomal subunit protein eL43A", "gene_name": "RPL43A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL43 RPL43A", "refseq_ac": "NP_015368", "gene_names_uniprotkb": "RPL43A; YP9499.02", "gene_names_refseq": "RPL43A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL43A; 60S ribosomal protein L43-A; L37a; YL35", "protein_names_refseq": "60S ribosomal protein eL43 RPL43A", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR094W-A); (sce:YPR043W)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11701127;11983894;14562095;14562106;14976550;17287358;21109664;22096102;24374639;24524803;33491328;9169875;9559554;9730282", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. 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The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRG8;P05746", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P0CX86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CX87-1", "uniprot_id": "RS32B_YEAST", "mass": 3337.0, "length": 25, "protein_name": "Small ribosomal subunit protein eS32B", "gene_name": "RPL41B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL41 RPL41B", "refseq_ac": "NP_010148", "gene_names_uniprotkb": "RPL41B; RPL47B; YDL133BC; YL41B", "gene_names_refseq": "RPL41B; RPL47B; YDL134C-A", "protein_names_uniprotkb": "Small ribosomal subunit protein eS32B; 60S ribosomal protein L41-B; L47; Large ribosomal subunit protein eL41B; YL41", "protein_names_refseq": "60S ribosomal protein eL41 RPL41B", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL133C-A); (sce:YDL184C)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11451953;11983894;14562095;14562106;18782943;2187623;22096102;24374639;24524803;8972577;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRG8;P05746", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P0CX87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10355-1", "uniprot_id": "PT122_YEAST", "mass": 29155.0, "length": 254, "protein_name": "Protein PET122, mitochondrial", "gene_name": "PET122", "organism": "Yeast", "refseq_name": "Pet122p", "refseq_ac": "NP_011080", "gene_names_uniprotkb": "PET122", "gene_names_refseq": "PET122", "protein_names_uniprotkb": "Protein PET122, mitochondrial", "protein_names_refseq": "Pet122p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER153C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;17322287;2160592;24374639;2849752;8389363;9169868", "class_list": "", "function": "Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM60", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070131 positive regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10355-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10566-1", "uniprot_id": "MRS3_YEAST", "mass": 34502.0, "length": 314, "protein_name": "Mitochondrial RNA-splicing protein MRS3", "gene_name": "MRS3", "organism": "Yeast", "refseq_name": "Fe(2+) transporter", "refseq_ac": "NP_012402", "gene_names_uniprotkb": "MRS3; J0675", "gene_names_refseq": "MRS3", "protein_names_uniprotkb": "Mitochondrial RNA-splicing protein MRS3", "protein_names_refseq": "Fe(2+) transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL133W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;1703236;24374639;2448588;8641269;8813765", "class_list": "", "function": "MRS3 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW52", "ec_number_list": "", "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10566-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10834-1", "uniprot_id": "PET54_YEAST", "mass": 34637.0, "length": 293, "protein_name": "Protein PET54", "gene_name": "PET54", "organism": "Yeast", "refseq_name": "Pet54p", "refseq_ac": "NP_011738", "gene_names_uniprotkb": "PET54; G8527", "gene_names_refseq": "PET54", "protein_names_uniprotkb": "Protein PET54; Petite colonies protein 54", "protein_names_refseq": "Pet54p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR222W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;24374639;2548921;2555177;8389363;8701610;9169869", "class_list": "", "function": "Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV04", "ec_number_list": "", "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0045182 translation regulator activity;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070131 positive regulation of mitochondrial translation;GO:0090615 mitochondrial mRNA processing;GO:0000372 Group I intron splicing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10834-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10849-1", "uniprot_id": "MITF2_YEAST", "mass": 51192.0, "length": 440, "protein_name": "Mitochondrial translation factor 2", "gene_name": "MTF2", "organism": "Yeast", "refseq_name": "Mtf2p", "refseq_ac": "NP_010240", "gene_names_uniprotkb": "MTF2; D2705; NAM1", "gene_names_refseq": "MTF2; NAM1", "protein_names_uniprotkb": "Mitochondrial translation factor 2; Protein NAM1", "protein_names_refseq": "Mtf2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL044C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;2183001;24374639;2651895;8413192;9046088;9169867", "class_list": "", "function": "Required for the processing and/or for the stability of the CYTB and COX1 intron-containing pre-mRNAs and of the ATP6 transcript. Could be a stem-loop RNA-binding protein that plays a role in determining RNA stability., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRV2;Q05430", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0006397 mRNA processing;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11927-1", "uniprot_id": "KAR1_YEAST", "mass": 50653.0, "length": 433, "protein_name": "Cell division control protein KAR1", "gene_name": "KAR1", "organism": "Yeast", "refseq_name": "Kar1p", "refseq_ac": "NP_014211", "gene_names_uniprotkb": "KAR1; N1611", "gene_names_refseq": "KAR1", "protein_names_uniprotkb": "Cell division control protein KAR1", "protein_names_refseq": "Kar1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL188W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10428957;17322287;19779198;23749301;24374639;3030557;32597660;33481703;33491328;7876310;8070654;9169873", "class_list": "", "function": "KAR1 is required for function of both intranuclear and extranuclear microtubules. KAR1 helps localize CDC31 to the spindle pole body (SPB), CDC31 then initiates SPB duplication via interaction with a downstream effector., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Z9;E9P8Y4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005874 microtubule;GO:0005825 half bridge of spindle pole body", "go_biological_process": "GO:0051301 cell division;GO:0030474 spindle pole body duplication;GO:0000742 karyogamy involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P11927-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12612-1", "uniprot_id": "TCPA_YEAST", "mass": 60481.0, "length": 559, "protein_name": "T-complex protein 1 subunit alpha", "gene_name": "TCP1", "organism": "Yeast", "refseq_name": "chaperonin-containing T-complex alpha subunit TCP1", "refseq_ac": "NP_010498", "gene_names_uniprotkb": "TCP1; CCT1; YD8142.13; YD8142B.04", "gene_names_refseq": "CCT1; TCP1", "protein_names_uniprotkb": "T-complex protein 1 subunit alpha; CCT-alpha; TCP-1-alpha", "protein_names_refseq": "chaperonin-containing T-complex alpha subunit TCP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR212W); (R-SCE-390471); (R-SCE-6814122)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "18407956;1901944;22814378;24374639;33481703;33491328;7908441;9169867", "class_list": "", "function": "Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSJ6", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P12612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12685-1", "uniprot_id": "TRK1_YEAST", "mass": 141073.0, "length": 1235, "protein_name": "High-affinity potassium transport protein", "gene_name": "TRK1", "organism": "Yeast", "refseq_name": "Trk1p", "refseq_ac": "NP_012406", "gene_names_uniprotkb": "TRK1; J0693", "gene_names_refseq": "TRK1", "protein_names_uniprotkb": "High-affinity potassium transport protein", "protein_names_refseq": "Trk1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL129C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17330950;18407956;19779198;21126336;23749301;24374639;3043197;32597660;33481703;33491328;34965436;8641269;8948101", "class_list": "", "function": "This protein is required for high-affinity potassium transport., [UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 15, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6VW56", "ec_number_list": "", "go_molecular_function": "GO:0015079 potassium ion transmembrane transporter activity;GO:0140107 high-affinity potassium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0071944 cell periphery", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P12685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12686-1", "uniprot_id": "RT13_YEAST", "mass": 38988.0, "length": 339, "protein_name": "Small ribosomal subunit protein mS27", "gene_name": "MRP13", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein mS44 MRP13", "refseq_ac": "NP_011598", "gene_names_uniprotkb": "MRP13", "gene_names_refseq": "MRP13; mS44", "protein_names_uniprotkb": "Small ribosomal subunit protein mS27; 37S ribosomal protein MRP13, mitochondrial; Small ribosomal subunit protein mS44; YmS-A", "protein_names_refseq": "mitochondrial 37S ribosomal protein mS44 MRP13", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR084C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12392552;14562095;14562106;14576278;21126336;24374639;25609543;28154081;3065621;33229814;9151978;9169869", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VUL6", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P12686-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12687-1", "uniprot_id": "RM02_YEAST", "mass": 43227.0, "length": 371, "protein_name": "Large ribosomal subunit protein bL27m", "gene_name": "MRP7", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL27m MRP7", "refseq_ac": "NP_014393", "gene_names_uniprotkb": "MRP7; MRPL2; N2007", "gene_names_refseq": "MRP7; bL27m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL27m; 54S ribosomal protein L2, mitochondrial; YMR6; YmL2", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL27m MRP7", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL005C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12392552;14562095;14562106;14576278;17322287;2060626;20702584;24374639;24675956;25609543;2693936;2851722;32597660;33491328;7941739;7985421;8220240;9169873", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1H2", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P12687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13090-1", "uniprot_id": "ATR1_YEAST", "mass": 59983.0, "length": 542, "protein_name": "Aminotriazole resistance protein", "gene_name": "ATR1", "organism": "Yeast", "refseq_name": "borate transporter", "refseq_ac": "NP_013591", "gene_names_uniprotkb": "ATR1; SNQ1; YM8339.03", "gene_names_refseq": "ATR1; SNQ1", "protein_names_uniprotkb": "Aminotriazole resistance protein", "protein_names_refseq": "borate transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YML116W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;16847258;17322287;18407956;2123132;24374639;3280970;33481703;33491328;9169872", "class_list": "", "function": "Putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. Probable ATP-dependent export permease. Appears to confer resistance only to aminotriazole., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0G8", "ec_number_list": "", "go_molecular_function": "GO:0080139 borate efflux transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0005773 vacuole", "go_biological_process": "GO:0046713 borate transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13090-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13181-1", "uniprot_id": "GAL2_YEAST", "mass": 63626.0, "length": 574, "protein_name": "Galactose transporter", "gene_name": "GAL2", "organism": "Yeast", "refseq_name": "galactose permease GAL2", "refseq_ac": "NP_013182", "gene_names_uniprotkb": "GAL2; IMP1; L9449.6", "gene_names_refseq": "GAL2", "protein_names_uniprotkb": "Galactose transporter; Galactose permease", "protein_names_refseq": "galactose permease GAL2", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR081W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16847258;19779198;24374639;2666404;2697639;9169871", "class_list": "", "function": "GAL2 is a facilitated diffusion transporter required for both the high-affinity galactokinase-dependent and low-affinity galactokinase-independent galactose transport processes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY81;Q12521", "ec_number_list": "", "go_molecular_function": "GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0006012 galactose metabolic process;GO:0015757 galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13181-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13188-1", "uniprot_id": "SYQ_YEAST", "mass": 93133.0, "length": 809, "protein_name": "Glutamine--tRNA ligase", "gene_name": "GLN4", "organism": "Yeast", "refseq_name": "glutamine--tRNA ligase", "refseq_ac": "NP_014811", "gene_names_uniprotkb": "GLN4; O3601", "gene_names_refseq": "GLN4", "protein_names_uniprotkb": "Glutamine--tRNA ligase; 6.1.1.18; GlnRS; Glutaminyl-tRNA synthetase", "protein_names_refseq": "glutamine--tRNA ligase", "tax_id": 559292, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (sce:YOR168W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;17563356;19779198;19795423;19823750;23749301;24374639;32597660;3301841;33481703;33491328;8972579;9169874", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2M6;Q12005", "ec_number_list": "6.1.1.18", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0004819 glutamine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006425 glutaminyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P13188-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13298-1", "uniprot_id": "PYRE_YEAST", "mass": 24664.0, "length": 226, "protein_name": "Orotate phosphoribosyltransferase 1", "gene_name": "URA5", "organism": "Yeast", "refseq_name": "orotate phosphoribosyltransferase URA5", "refseq_ac": "NP_013601", "gene_names_uniprotkb": "URA5; PYR5; YM8339.13", "gene_names_refseq": "PYR5; URA5", "protein_names_uniprotkb": "Orotate phosphoribosyltransferase 1; 2.4.2.10; OPRT 1; OPRTase 1", "protein_names_refseq": "orotate phosphoribosyltransferase URA5", "tax_id": 559292, "disease": "", "pathway": " (sce:YML106W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;17322287;19779198;23749301;24374639;2651891;33481703;33491328;9169872", "class_list": "", "function": "Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0H8", "ec_number_list": "2.4.2.10", "go_molecular_function": "GO:0004588 orotate phosphoribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006221 pyrimidine nucleotide biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process;GO:0046132 pyrimidine ribonucleoside biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P13298-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13434-1", "uniprot_id": "HAP3_YEAST", "mass": 16154.0, "length": 144, "protein_name": "Transcriptional activator HAP3", "gene_name": "HAP3", "organism": "Yeast", "refseq_name": "Hap3p", "refseq_ac": "NP_009532", "gene_names_uniprotkb": "HAP3; YBL0441", "gene_names_refseq": "HAP3", "protein_names_uniprotkb": "Transcriptional activator HAP3; UAS2 regulatory protein A", "protein_names_refseq": "Hap3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL021C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11390369;14562106;16278450;17322287;24374639;2832732;7813418;8223474;8276800", "class_list": "", "function": "Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPX9", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0006109 regulation of carbohydrate metabolic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P13434-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13483-1", "uniprot_id": "DATI_YEAST", "mass": 27067.0, "length": 248, "protein_name": "Oligo(A)/oligo(T)-binding protein", "gene_name": "DAT1", "organism": "Yeast", "refseq_name": "Dat1p", "refseq_ac": "NP_013594", "gene_names_uniprotkb": "DAT1; DAT; YM8339.06", "gene_names_refseq": "DAT1", "protein_names_uniprotkb": "Oligo(A)/oligo(T)-binding protein; Datin", "protein_names_refseq": "Dat1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML113W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;17322287;19779198;22814378;23749301;24374639;2670564;32597660;33481703;33491328;8532535;9169872", "class_list": "", "function": "DNA-binding protein that recognizes oligo(A).oligo(T) tracts (A.T DNA). Can bind to any 11 bp sequence in which 10 bases conform to an uninterrupted oligo(A).oligo(T) tract., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0H1", "ec_number_list": "", "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P13483-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13711-1", "uniprot_id": "ACOX_YEAST", "mass": 84042.0, "length": 748, "protein_name": "Acyl-coenzyme A oxidase", "gene_name": "POX1", "organism": "Yeast", "refseq_name": "acyl-CoA oxidase", "refseq_ac": "NP_011310", "gene_names_uniprotkb": "POX1; FOX1", "gene_names_refseq": "FOX1; POX1", "protein_names_uniprotkb": "Acyl-coenzyme A oxidase; 1.3.3.6; Acyl-CoA oxidase", "protein_names_refseq": "acyl-CoA oxidase", "tax_id": 559292, "disease": "peroxisomal acyl-CoA oxidase deficiency (Disease Ontology:DOID:0050797); Mitchell syndrome (Disease Ontology:DOID:0070516); congenital bile acid synthesis defect 6 (Disease Ontology:DOID:0111067); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YGL205W); (R-SCE-389887)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "2189786;24374639;33229814;33491328;9153757;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VTV0", "ec_number_list": "1.3.3.6", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0003997 acyl-CoA oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13902-1", "uniprot_id": "INO4_YEAST", "mass": 17378.0, "length": 151, "protein_name": "Protein INO4", "gene_name": "INO4", "organism": "Yeast", "refseq_name": "Ino4p", "refseq_ac": "NP_014533", "gene_names_uniprotkb": "INO4; HRF151", "gene_names_refseq": "INO4", "protein_names_uniprotkb": "Protein INO4", "protein_names_refseq": "Ino4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL108C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17322287;2155238;23749301;24374639;33491328;7502582;9169874", "class_list": "", "function": "Transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1V9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P13902-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14063-1", "uniprot_id": "RM31_YEAST", "mass": 15520.0, "length": 131, "protein_name": "Large ribosomal subunit protein mL60", "gene_name": "MRPL31", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein mL60 MRPL31", "refseq_ac": "NP_012784", "gene_names_uniprotkb": "MRPL31", "gene_names_refseq": "MRPL31; mL60", "protein_names_uniprotkb": "Large ribosomal subunit protein mL60; 54S ribosomal protein L31, mitochondrial; YmL31", "protein_names_refseq": "mitochondrial 54S ribosomal protein mL60 MRPL31", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL138C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12392552;14562095;14562106;24374639;24675956;25609543;2666132;3060376;8196765", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX59", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P14063-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14066-1", "uniprot_id": "CBS1_YEAST", "mass": 26586.0, "length": 229, "protein_name": "Cytochrome b translational activator protein CBS1, mitochondrial", "gene_name": "CBS1", "organism": "Yeast", "refseq_name": "Cbs1p", "refseq_ac": "NP_010214", "gene_names_uniprotkb": "CBS1", "gene_names_refseq": "CBS1", "protein_names_uniprotkb": "Cytochrome b translational activator protein CBS1, mitochondrial; COB-specific translational activator protein CBS1", "protein_names_refseq": "Cbs1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL069C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10669873;12748633;14562106;14576278;1657414;1745228;24374639;2550765;2671648;9169867", "class_list": "", "function": "mRNA-specific translational activator of cytochrome b. The cytochrome b (COB) leader RNA may represent the target sequence for CBS1 and CBS2, tethering the COB mRNA to the inner mitochondrial membrane, where cotranslational insertion of cytochrome b into the membrane can occur., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRS9", "ec_number_list": "", "go_molecular_function": "GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0070131 positive regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P14066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14843-1", "uniprot_id": "AROF_YEAST", "mass": 41070.0, "length": 370, "protein_name": "Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited", "gene_name": "ARO3", "organism": "Yeast", "refseq_name": "3-deoxy-7-phosphoheptulonate synthase ARO3", "refseq_ac": "NP_010320", "gene_names_uniprotkb": "ARO3; YD9673.07", "gene_names_refseq": "ARO3", "protein_names_uniprotkb": "Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited; 2.5.1.54; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase", "protein_names_refseq": "3-deoxy-7-phosphoheptulonate synthase ARO3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR035W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;17322287;17563356;18407956;22814378;24374639;2906401;33481703;33491328;9169867", "class_list": "", "function": "Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS23", "ec_number_list": "2.5.1.54", "go_molecular_function": "GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0008652 amino acid biosynthetic process;GO:0009073 aromatic amino acid family biosynthetic process;GO:0009423 chorismate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P14843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15179-1", "uniprot_id": "SYDM_YEAST", "mass": 75461.0, "length": 658, "protein_name": "Aspartate--tRNA ligase, mitochondrial", "gene_name": "MSD1", "organism": "Yeast", "refseq_name": "aspartate--tRNA ligase MSD1", "refseq_ac": "NP_015221", "gene_names_uniprotkb": "MSD1; LPG5W", "gene_names_refseq": "LPG5; MSD1", "protein_names_uniprotkb": "Aspartate--tRNA ligase, mitochondrial; 6.1.1.12; AspRS; Aspartyl-tRNA synthetase", "protein_names_refseq": "aspartate--tRNA ligase MSD1", "tax_id": 559292, "disease": "leukodystrophy (Disease Ontology:DOID:10579)", "pathway": " (sce:YPL104W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;24374639;2668951;33491328;9169875", "class_list": "", "function": "Catalyzes the attachment of aspartate to tRNA(Asp) in the mitochondrion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3R3", "ec_number_list": "6.1.1.12", "go_molecular_function": "GO:0004815 aspartate-tRNA ligase activity;GO:0005524 ATP binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006422 aspartyl-tRNA aminoacylation;GO:0070146 mitochondrial aspartyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15179-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15365-1", "uniprot_id": "DAL5_YEAST", "mass": 60850.0, "length": 543, "protein_name": "Allantoate permease", "gene_name": "DAL5", "organism": "Yeast", "refseq_name": "allantoate permease", "refseq_ac": "NP_012686", "gene_names_uniprotkb": "DAL5; J2230; UREP1", "gene_names_refseq": "DAL5; UREP1", "protein_names_uniprotkb": "Allantoate permease", "protein_names_refseq": "allantoate permease", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YJR152W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16847258;24374639;3275614;34965436;8641269", "class_list": "", "function": "Component of the allantoate transport system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWX1", "ec_number_list": "", "go_molecular_function": "GO:0071916 dipeptide transmembrane transporter activity;GO:0015124 allantoate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0042938 dipeptide transport;GO:0015719 allantoate transport;GO:0042939 tripeptide transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15365-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15380-1", "uniprot_id": "PUT4_YEAST", "mass": 68788.0, "length": 627, "protein_name": "Proline-specific permease", "gene_name": "PUT4", "organism": "Yeast", "refseq_name": "proline permease PUT4", "refseq_ac": "NP_014993", "gene_names_uniprotkb": "PUT4; O6345", "gene_names_refseq": "PUT4", "protein_names_uniprotkb": "Proline-specific permease", "protein_names_refseq": "proline permease PUT4", "tax_id": 559292, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374)", "pathway": " (sce:YOR348C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10654085;20702584;24374639;2687114;33481703;33491328;8948102;9169874", "class_list": "", "function": "Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also functions as a non-specific GABA permease. Can also transport alanine and glycine., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W343", "ec_number_list": "", "go_molecular_function": "GO:0015193 L-proline transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015824 proline transport;GO:0015804 neutral amino acid transport;GO:0003333 amino acid transmembrane transport;GO:0015812 gamma-aminobutyric acid transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P15380-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17121-1", "uniprot_id": "SAC7_YEAST", "mass": 73629.0, "length": 654, "protein_name": "GTPase-activating protein SAC7", "gene_name": "SAC7", "organism": "Yeast", "refseq_name": "GTPase-activating protein SAC7", "refseq_ac": "NP_010677", "gene_names_uniprotkb": "SAC7", "gene_names_refseq": "SAC7", "protein_names_uniprotkb": "GTPase-activating protein SAC7", "protein_names_refseq": "GTPase-activating protein SAC7", "tax_id": 559292, "disease": "EEC syndrome (Disease Ontology:DOID:0060782)", "pathway": " (sce:YDR389W); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013148); (R-SCE-9013149)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;2183030;22218487;23749301;24374639;32597660;33481703;33491328;34965436;9038344;9169867", "class_list": "", "function": "GTPase-activating protein for RHO1. Must be involved in the normal assembly or function or both of actin. Plays an essential role only at low temperatures., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT23;Q04163", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005938 cell cortex", "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0035024 negative regulation of Rho protein signal transduction;GO:0060237 regulation of fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P17121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17260-1", "uniprot_id": "KRE1_YEAST", "mass": 32158.0, "length": 313, "protein_name": "Protein KRE1", "gene_name": "KRE1", "organism": "Yeast", "refseq_name": "Kre1p", "refseq_ac": "NP_014077", "gene_names_uniprotkb": "KRE1; N0336", "gene_names_refseq": "KRE1", "protein_names_uniprotkb": "Protein KRE1; Killer toxin-resistance protein 1", "protein_names_refseq": "Kre1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL322C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11853673;14562106;15470101;2186051;24374639;33491328;7500943;7502583;7645347;9169873", "class_list": "", "function": "Involved in a late stage of cell wall 1,6-beta-glucan synthesis and assembly. Has a structural, rather than enzymic, function within cell wall 1,6-beta-glucan assembly and architecture, possibly by being involved in covalently cross-linking 1,6-beta-glucans to other cell wall components such as 1,3-beta-glucan, chitin and certain mannoproteins. Acts as the plasma membrane receptor for the yeast K1 viral toxin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0M4", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P17260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17261-1", "uniprot_id": "ERS1_YEAST", "mass": 30116.0, "length": 260, "protein_name": "Cystine transporter", "gene_name": "ERS1", "organism": "Yeast", "refseq_name": "cystinosin-like protein ERS1", "refseq_ac": "NP_010000", "gene_names_uniprotkb": "ERS1; YCR75C", "gene_names_refseq": "ERS1", "protein_names_uniprotkb": "Cystine transporter; ERD suppressor; Transmembrane protein ERS1", "protein_names_refseq": "cystinosin-like protein ERS1", "tax_id": 559292, "disease": "familial hyperinsulinemic hypoglycemia 7 (Disease Ontology:DOID:0070214); congenital disorder of glycosylation type IIj (Disease Ontology:DOID:0070262); nemaline myopathy 7 (Disease Ontology:DOID:0110934); Fanconi syndrome (Disease Ontology:DOID:1062); cystinosis (Disease Ontology:DOID:1064); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); adenocarcinoma (Disease Ontology:DOID:299); carcinoma (Disease Ontology:DOID:305); ischemia (Disease Ontology:DOID:326); colorectal cancer (Disease Ontology:DOID:9256); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YCR075C); (R-SCE-5223345); (R-SCE-9959399)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1574125;15885099;2186379;24374639", "class_list": "", "function": "Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from vacuoles/endodomes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VR77", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0015184 L-cystine transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015811 L-cystine transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P17261-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17423-1", "uniprot_id": "KHSE_YEAST", "mass": 38712.0, "length": 357, "protein_name": "Homoserine kinase", "gene_name": "THR1", "organism": "Yeast", "refseq_name": "homoserine kinase", "refseq_ac": "NP_011890", "gene_names_uniprotkb": "THR1", "gene_names_refseq": "THR1", "protein_names_uniprotkb": "Homoserine kinase; 2.7.1.39; HK; HSK", "protein_names_refseq": "homoserine kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR025W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;18407956;20305002;20305003;2165904;2176637;22106047;24374639;33481703;33491328;8091229", "class_list": "", "function": "Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKX2", "ec_number_list": "2.7.1.39", "go_molecular_function": "GO:0005524 ATP binding;GO:0004413 homoserine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0009088 threonine biosynthetic process;GO:0009092 homoserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P17423-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17536-1", "uniprot_id": "TPM1_YEAST", "mass": 23541.0, "length": 199, "protein_name": "Tropomyosin-1", "gene_name": "TPM1", "organism": "Yeast", "refseq_name": "tropomyosin TPM1", "refseq_ac": "NP_014320", "gene_names_uniprotkb": "TPM1; N2332", "gene_names_refseq": "TPM1", "protein_names_uniprotkb": "Tropomyosin-1", "protein_names_refseq": "tropomyosin TPM1", "tax_id": 559292, "disease": "congenital myopathy 4A (Disease Ontology:DOID:0080102); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 3 (Disease Ontology:DOID:0110309); dilated cardiomyopathy 1Y (Disease Ontology:DOID:0110457); congenital myopathy 4B (Disease Ontology:DOID:0110926); congenital myopathy 23 (Disease Ontology:DOID:0110932); distal arthrogryposis type 1A (Disease Ontology:DOID:0111597); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (sce:YNL079C); (R-SCE-9013424)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;16273108;17322287;18407956;19795423;19823750;21126336;21177495;22106047;22218487;24374639;2649250;33481703;33491328;34965436;8701611;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1A0;Q45TY1", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0003786 actin lateral binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005826 actomyosin contractile ring;GO:0032432 actin filament bundle;GO:0000142 cellular bud neck contractile ring", "go_biological_process": "GO:0007015 actin filament organization;GO:0051017 actin filament bundle assembly;GO:0000281 mitotic cytokinesis;GO:0071474 cellular hyperosmotic response;GO:1903475 mitotic actomyosin contractile ring assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P17536-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18408-1", "uniprot_id": "MET16_YEAST", "mass": 30380.0, "length": 261, "protein_name": "Phosphoadenosine phosphosulfate reductase", "gene_name": "MET16", "organism": "Yeast", "refseq_name": "phosphoadenylyl-sulfate reductase (thioredoxin)", "refseq_ac": "NP_015493", "gene_names_uniprotkb": "MET16; P9325.8", "gene_names_refseq": "MET16", "protein_names_uniprotkb": "Phosphoadenosine phosphosulfate reductase; 1.8.4.8; 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAdoPS reductase", "protein_names_refseq": "phosphoadenylyl-sulfate reductase (thioredoxin)", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR167C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17322287;2203779;24374639;33491328;9169875", "class_list": "", "function": "The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4G8;Q06212", "ec_number_list": "1.8.4.8", "go_molecular_function": "GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity;GO:0098624 3'-phosphoadenylylselenate reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0009086 methionine biosynthetic process;GO:0019344 cysteine biosynthetic process;GO:0070814 hydrogen sulfide biosynthetic process;GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18408-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18414-1", "uniprot_id": "ERD2_YEAST", "mass": 25763.0, "length": 219, "protein_name": "ER lumen protein-retaining receptor", "gene_name": "ERD2", "organism": "Yeast", "refseq_name": "Erd2p", "refseq_ac": "NP_009513", "gene_names_uniprotkb": "ERD2; YBL0408", "gene_names_refseq": "ERD2", "protein_names_uniprotkb": "ER lumen protein-retaining receptor; Endoplasmic reticulum retention defective protein 2; HDEL receptor", "protein_names_refseq": "Erd2p", "tax_id": 559292, "disease": "osteogenesis imperfecta type 21 (Disease Ontology:DOID:0112201)", "pathway": " (sce:YBL040C); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "2178921;2194670;2194671;24374639;29897761;7813418;7871888", "class_list": "", "function": "Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor strongly recognizes H-D-E-L and weakly recognizes D-D-E-L and K-D-E-L., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPV8", "ec_number_list": "", "go_molecular_function": "GO:0046923 ER retention sequence binding;GO:0045015 HDEL sequence binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18414-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18544-1", "uniprot_id": "ARGD_YEAST", "mass": 46681.0, "length": 423, "protein_name": "Acetylornithine aminotransferase, mitochondrial", "gene_name": "ARG8", "organism": "Yeast", "refseq_name": "acetylornithine transaminase", "refseq_ac": "NP_014501", "gene_names_uniprotkb": "ARG8", "gene_names_refseq": "ARG8", "protein_names_uniprotkb": "Acetylornithine aminotransferase, mitochondrial; 2.6.1.11; ACOAT", "protein_names_refseq": "acetylornithine transaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL140W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;205532;2199330;24374639;33491328;7502581;9169874", "class_list": "", "function": "catalyzes the conversion of N-acetylglutamate-gamma-semialdehyde (NAGSA) to N-acetylornithine in arginine biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S9", "ec_number_list": "2.6.1.11", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006526 L-arginine biosynthetic process;GO:0006592 ornithine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18544-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18963-1", "uniprot_id": "IRA1_YEAST", "mass": 350980.0, "length": 3092, "protein_name": "Inhibitory regulator protein IRA1", "gene_name": "IRA1", "organism": "Yeast", "refseq_name": "GTPase-activating protein IRA1", "refseq_ac": "NP_009698", "gene_names_uniprotkb": "IRA1; GLC1; PPD1; YBR1016", "gene_names_refseq": "GLC1; IRA1; PPD1", "protein_names_uniprotkb": "Inhibitory regulator protein IRA1", "protein_names_refseq": "GTPase-activating protein IRA1", "tax_id": 559292, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); spinal neurofibromatosis (Disease Ontology:DOID:0070482); Watson syndrome (Disease Ontology:DOID:0070483); colorectal carcinoma (Disease Ontology:DOID:0080199); neurofibromatosis 1 (Disease Ontology:DOID:0111253); neurofibromatosis-Noonan syndrome (Disease Ontology:DOID:0111683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); optic nerve glioma (Disease Ontology:DOID:4992); plexiform neurofibroma (Disease Ontology:DOID:5151); sleep disorder (Disease Ontology:DOID:535); neurofibromatosis (Disease Ontology:DOID:8712); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YBR140C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;17563356;18407956;19779198;21126336;21177495;23749301;24374639;2540426;32597660;33481703;33491328;7754712;7813418;8091856", "class_list": "", "function": "Inhibitory regulator of the Ras-cyclic AMP pathway in S.cerevisiae. Stimulates the GTPase activity of Ras proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQD6", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P18963-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19158-1", "uniprot_id": "IRA2_YEAST", "mass": 351669.0, "length": 3079, "protein_name": "Inhibitory regulator protein IRA2", "gene_name": "IRA2", "organism": "Yeast", "refseq_name": "Ras GTPase activating protein IRA2", "refseq_ac": "NP_014560", "gene_names_uniprotkb": "IRA2; CCS1; GLC4; O0985", "gene_names_refseq": "CCS1; GLC4; IRA2", "protein_names_uniprotkb": "Inhibitory regulator protein IRA2", "protein_names_refseq": "Ras GTPase activating protein IRA2", "tax_id": 559292, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); spinal neurofibromatosis (Disease Ontology:DOID:0070482); Watson syndrome (Disease Ontology:DOID:0070483); colorectal carcinoma (Disease Ontology:DOID:0080199); neurofibromatosis 1 (Disease Ontology:DOID:0111253); neurofibromatosis-Noonan syndrome (Disease Ontology:DOID:0111683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); optic nerve glioma (Disease Ontology:DOID:4992); plexiform neurofibroma (Disease Ontology:DOID:5151); sleep disorder (Disease Ontology:DOID:535); neurofibromatosis (Disease Ontology:DOID:8712); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YOL081W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11875433;1326414;14562095;15665377;17287358;17563356;18407956;19684113;19779198;20702584;21126336;21177495;2164637;22218487;23749301;24374639;30856163;32597660;33481703;33491328;7900427;8533473;9169874;9178509", "class_list": "", "function": "Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Y7;O13592;Q08239", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P19158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19516-1", "uniprot_id": "COX11_YEAST", "mass": 34044.0, "length": 300, "protein_name": "Cytochrome c oxidase assembly protein COX11, mitochondrial", "gene_name": "COX11", "organism": "Yeast", "refseq_name": "Cox11p", "refseq_ac": "NP_015193", "gene_names_uniprotkb": "COX11; LPI13W; PSO7", "gene_names_refseq": "COX11; LPI13; PSO7", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX11, mitochondrial", "protein_names_refseq": "Cox11p", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 23 (Disease Ontology:DOID:0070485); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (sce:YPL132W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10501934;12063264;1325447;15199057;15776235;15840584;16524911;2167832;22984289;24374639;25926683;33481703;34919594;35750769;38068960;9169875", "class_list": "", "function": "Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:12063264, PubMed:16524911, PubMed:2167832). Probably acts as a metallochaperone that delivers copper to the copper B site of COX1 (By similarity). Binds cuprous ions delivered by metallochaperone COX17 (PubMed:12063264, PubMed:15199057). Additionally, may play a role in the detoxification of reactive oxygen species (PubMed:34919594)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 27, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3N5", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:1903136 cuprous ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0045454 cell redox homeostasis;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0009060 aerobic respiration;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P19516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19735-1", "uniprot_id": "PRP6_YEAST", "mass": 104229.0, "length": 899, "protein_name": "Pre-mRNA-splicing factor 6", "gene_name": "PRP6", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit PRP6", "refseq_ac": "NP_009611", "gene_names_uniprotkb": "PRP6; RNA6; YBR0508", "gene_names_refseq": "PRP6; RNA6; TSM7269", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 6", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit PRP6", "tax_id": 559292, "disease": "retinitis pigmentosa 60 (Disease Ontology:DOID:0110411)", "pathway": " (sce:YBR055C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10449419;14562106;18953335;2118103;24374639;33491328;7597852;7813418", "class_list": "", "function": "Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ54", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0071001 U4/U6 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P19735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19736-1", "uniprot_id": "PRP9_YEAST", "mass": 63029.0, "length": 530, "protein_name": "Pre-mRNA-splicing factor PRP9", "gene_name": "PRP9", "organism": "Yeast", "refseq_name": "SF3a splicing factor complex subunit PRP9", "refseq_ac": "NP_010254", "gene_names_uniprotkb": "PRP9; D2773", "gene_names_refseq": "PRP9", "protein_names_uniprotkb": "Pre-mRNA-splicing factor PRP9", "protein_names_refseq": "SF3a splicing factor complex subunit PRP9", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL030W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11884590;14562106;2118103;24374639;33491328;9169867", "class_list": "", "function": "mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRW2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P19736-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19881-1", "uniprot_id": "PGP_YEAST", "mass": 34625.0, "length": 312, "protein_name": "Phosphoglycolate phosphatase", "gene_name": "PHO13", "organism": "Yeast", "refseq_name": "4-nitrophenylphosphatase", "refseq_ac": "NP_010045", "gene_names_uniprotkb": "PHO13", "gene_names_refseq": "PHO13", "protein_names_uniprotkb": "Phosphoglycolate phosphatase; 3.1.3.18", "protein_names_refseq": "4-nitrophenylphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL236W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;17563356;18407956;22218487;24374639;2558283;27294321;33481703;33491328;9169867", "class_list": "", "function": "Phosphatase with activity against multiple substrates (PubMed:27294321). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (PubMed:27294321). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (PubMed:27294321). Dephosphorylates 4-phosphoerythronate, a side product produced by glyceraldehyde-3-phosphate dehydrogenase which inhibits 6-phosphogluconate dehydrogenase (PubMed:27294321). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (PubMed:27294321). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (PubMed:27294321). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (PubMed:27294321). Dispensable for vegetative growth and sporulation (PubMed:2558283)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRC0;Q07689", "ec_number_list": "3.1.3.18", "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0008967 phosphoglycolate phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P19881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20048-1", "uniprot_id": "DOLK_YEAST", "mass": 58906.0, "length": 519, "protein_name": "Dolichol kinase", "gene_name": "SEC59", "organism": "Yeast", "refseq_name": "dolichol kinase", "refseq_ac": "NP_013726", "gene_names_uniprotkb": "SEC59; YM8270.17C", "gene_names_refseq": "SEC59", "protein_names_uniprotkb": "Dolichol kinase; 2.7.1.108", "protein_names_refseq": "dolichol kinase", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Im (Disease Ontology:DOID:0080565)", "pathway": " (sce:YMR013C); (R-SCE-446199)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12213788;1323123;16847258;17322287;18407956;24374639;2657387;33491328;9169872", "class_list": "", "function": "Catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate (Dol-P) biosynthesis (PubMed:12213788, PubMed:1323123, PubMed:2657387). Dol-P is a lipid carrier essential for the synthesis of N-linked and O-linked oligosaccharides and for GPI anchors (PubMed:12213788, PubMed:1323123, PubMed:2657387)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZI7", "ec_number_list": "2.7.1.108", "go_molecular_function": "GO:0004168 dolichol kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20051-1", "uniprot_id": "PYRC_YEAST", "mass": 40313.0, "length": 364, "protein_name": "Dihydroorotase", "gene_name": "URA4", "organism": "Yeast", "refseq_name": "dihydroorotase", "refseq_ac": "NP_013524", "gene_names_uniprotkb": "URA4; L9931.1", "gene_names_refseq": "URA4", "protein_names_uniprotkb": "Dihydroorotase; 3.5.2.3; DHOase", "protein_names_refseq": "dihydroorotase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR420W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24374639;2897615;33481703;33491328;9169871", "class_list": "", "function": "Catalyzes the conversion of ureidosuccinic acid (USA) to dihydroorotate, the third step of the de novo pyrimidine biosynthetic pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ56", "ec_number_list": "3.5.2.3", "go_molecular_function": "GO:0004151 dihydroorotase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006221 pyrimidine nucleotide biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20084-1", "uniprot_id": "RM33_YEAST", "mass": 9531.0, "length": 86, "protein_name": "Large ribosomal subunit protein uL30m", "gene_name": "MRPL33", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL30m MRPL33", "refseq_ac": "NP_014013", "gene_names_uniprotkb": "MRPL33; YM8021.12", "gene_names_refseq": "MRPL33; uL30m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30m; 54S ribosomal protein L33, mitochondrial; YmL33", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL30m MRPL33", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR286W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14576278;17322287;2060626;2061283;24374639;24675956;25609543;33491328;9169872", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0B3", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P20084-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20134-1", "uniprot_id": "SFL1_YEAST", "mass": 83345.0, "length": 766, "protein_name": "Flocculation suppression protein", "gene_name": "SFL1", "organism": "Yeast", "refseq_name": "Sfl1p", "refseq_ac": "NP_014783", "gene_names_uniprotkb": "SFL1; YOR3339W", "gene_names_refseq": "SFL1", "protein_names_uniprotkb": "Flocculation suppression protein; Protein SFL1", "protein_names_refseq": "Sfl1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR140W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562095;14562106;15665377;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21177495;23749301;24374639;2697640;28270554;30516470;32597660;33229814;33481703;33491328;9169874;9200815", "class_list": "", "function": "Involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation). Mutations in SFL1 causes constitutive cell aggregation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6W2J6;Q99194", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:2000218 negative regulation of invasive growth in response to glucose limitation;GO:2000221 negative regulation of pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P20134-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20484-1", "uniprot_id": "MAK11_YEAST", "mass": 47291.0, "length": 414, "protein_name": "Protein MAK11", "gene_name": "MAK11", "organism": "Yeast", "refseq_name": "Mak11p", "refseq_ac": "NP_012904", "gene_names_uniprotkb": "MAK11", "gene_names_refseq": "MAK11", "protein_names_uniprotkb": "Protein MAK11; Maintenance of killer protein 11", "protein_names_refseq": "Mak11p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL021C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12374754;12808088;14562106;17330950;18407956;19779198;22814378;24374639;2826479;33481703;7739558;8196765", "class_list": "", "function": "Essential for cell growth. Plays a role in assembly of 60S pre-ribosomal particles in the nucleolus. Also required for replication of the M1 double-stranded RNA of the L-A virus. This latter function may reflect an enhanced requirement for free 60S ribosomal particles for the translation of viral mRNAs which lack poly-A tails., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXR4", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000027 ribosomal large subunit assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P20484-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21304-1", "uniprot_id": "PWP1_YEAST", "mass": 63803.0, "length": 576, "protein_name": "Periodic tryptophan protein 1", "gene_name": "PWP1", "organism": "Yeast", "refseq_name": "rRNA-processing protein PWP1", "refseq_ac": "NP_013297", "gene_names_uniprotkb": "PWP1; L8167.10", "gene_names_refseq": "PWP1", "protein_names_uniprotkb": "Periodic tryptophan protein 1", "protein_names_refseq": "rRNA-processing protein PWP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR196W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;15665377;1594577;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;34965436;9169871", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYJ9", "ec_number_list": "", "go_molecular_function": "GO:1990889 histone H4K20me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006364 rRNA processing;GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P21304-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21595-1", "uniprot_id": "CP56_YEAST", "mass": 56071.0, "length": 489, "protein_name": "Cytochrome P450-DIT2", "gene_name": "DIT2", "organism": "Yeast", "refseq_name": "putative cytochrome P450", "refseq_ac": "NP_010690", "gene_names_uniprotkb": "DIT2; CYP56; D9509.20", "gene_names_refseq": "CYP56; DIT2", "protein_names_uniprotkb": "Cytochrome P450-DIT2; 1.14.14.-; Cytochrome P450 56", "protein_names_refseq": "putative cytochrome P450", "tax_id": 559292, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); autosomal recessive congenital ichthyosis 5 (Disease Ontology:DOID:0060714)", "pathway": " (sce:YDR402C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2249774;24374639;8183942;9169867", "class_list": "", "function": "Involved in spore wall maturation. Thought to catalyze the oxidation of tyrosine residues in the formation of LL-dityrosine a precursor of the spore wall., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT34", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0003959 NADPH dehydrogenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21595-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21657-1", "uniprot_id": "DAL81_YEAST", "mass": 109174.0, "length": 970, "protein_name": "Transcriptional activator protein DAL81", "gene_name": "DAL81", "organism": "Yeast", "refseq_name": "Dal81p", "refseq_ac": "NP_012289", "gene_names_uniprotkb": "DAL81; DURL; UGA35", "gene_names_refseq": "DAL81; UGA35", "protein_names_uniprotkb": "Transcriptional activator protein DAL81; Regulatory protein UGA35", "protein_names_refseq": "Dal81p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR023W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562106;15665377;17563356;18407956;19684113;19779198;19795423;19823750;1990272;1999281;20489023;20702584;23749301;24374639;24909858;32597660;33481703;33491328;9169870", "class_list": "", "function": "Positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2), urea (DUR1 and DUR2), arginine and allantoin., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVV4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:1901714 positive regulation of urea catabolic process;GO:1901717 positive regulation of gamma-aminobutyric acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P21657-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21771-1", "uniprot_id": "RT28_YEAST", "mass": 33057.0, "length": 286, "protein_name": "Small ribosomal subunit protein uS15m", "gene_name": "MRPS28", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein uS15m MRPS28", "refseq_ac": "NP_010624", "gene_names_uniprotkb": "MRPS28; D9651.3", "gene_names_refseq": "MRPS28; uS15m", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15m; 37S ribosomal protein S28, mitochondrial", "protein_names_refseq": "mitochondrial 37S ribosomal protein uS15m MRPS28", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR337W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11278769;12392552;14562095;14562106;14576278;17322287;2263452;24374639;25609543;28154081;7593000;9169867", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSW9", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P21771-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22035-1", "uniprot_id": "BAS1_YEAST", "mass": 89604.0, "length": 811, "protein_name": "Myb-like DNA-binding protein BAS1", "gene_name": "BAS1", "organism": "Yeast", "refseq_name": "Bas1p", "refseq_ac": "NP_013025", "gene_names_uniprotkb": "BAS1", "gene_names_refseq": "BAS1", "protein_names_uniprotkb": "Myb-like DNA-binding protein BAS1", "protein_names_refseq": "Bas1p", "tax_id": 559292, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); myelodysplastic syndrome (Disease Ontology:DOID:0050908); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential thrombocythemia (Disease Ontology:DOID:2224); transient cerebral ischemia (Disease Ontology:DOID:224); myelofibrosis (Disease Ontology:DOID:4971); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YKR099W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;18407956;19779198;23749301;24374639;2683089;32597660;33481703;33491328;8021277;8196765;9822821", "class_list": "", "function": "Activates HIS4 transcription only in combination with PHO2/BAS2. BAS1 is also involved in the regulation of the purine biosynthesis pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXG0", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P22035-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22135-1", "uniprot_id": "ATP12_YEAST", "mass": 36554.0, "length": 325, "protein_name": "Protein ATP12, mitochondrial", "gene_name": "ATP12", "organism": "Yeast", "refseq_name": "ATP synthase complex assembly protein ATP12", "refseq_ac": "NP_012355", "gene_names_uniprotkb": "ATP12; J0486", "gene_names_refseq": "ATP12", "protein_names_uniprotkb": "Protein ATP12, mitochondrial", "protein_names_refseq": "ATP synthase complex assembly protein ATP12", "tax_id": 559292, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 1 (Disease Ontology:DOID:0050768)", "pathway": " (sce:YJL180C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;16823961;1826907;22984289;24374639;33491328;8641269", "class_list": "", "function": "Essential for the assembly of the mitochondrial F1-F0 complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW09", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22135-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22136-1", "uniprot_id": "AEP2_YEAST", "mass": 67523.0, "length": 580, "protein_name": "ATPase expression protein 2, mitochondrial", "gene_name": "AEP2", "organism": "Yeast", "refseq_name": "Aep2p", "refseq_ac": "NP_014009", "gene_names_uniprotkb": "AEP2; ATP13; YM8021.08C", "gene_names_refseq": "AEP2; ATP13", "protein_names_uniprotkb": "ATPase expression protein 2, mitochondrial", "protein_names_refseq": "Aep2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR282C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10101162;14562106;1718609;1825065;19779198;24374639;7954819;9169872", "class_list": "", "function": "Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0A9;P23115", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P22136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22148-1", "uniprot_id": "MSN1_YEAST", "mass": 43060.0, "length": 382, "protein_name": "Protein MSN1", "gene_name": "MSN1", "organism": "Yeast", "refseq_name": "Msn1p", "refseq_ac": "NP_014525", "gene_names_uniprotkb": "MSN1; FUP1; HRB382; PHD2", "gene_names_refseq": "FUP1; HRB382; MSN1; MSS10; PHD2", "protein_names_uniprotkb": "Protein MSN1; Multicopy suppressor of SNF1 protein 1", "protein_names_refseq": "Msn1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL116W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;1564445;18407956;19779198;19795423;19823750;2263457;23749301;24374639;32597660;33481703;33491328;33502312;7502582;9169874", "class_list": "", "function": "May function as a transcriptional activator. Increased dosage of MSN1 restores invertase expression in yeast mutants defective in the SNF1 protein kinase, and msn1 disruption reduced derepression of invertase in the wild-type. May affect SUC2 expression. Expression of MSN1 enhances growth in iron-limiting conditions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1V1;Q12227;Q9URF6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0097238 cellular response to methylglyoxal;GO:0071475 cellular hyperosmotic salinity response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P22148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22202-1", "uniprot_id": "HSP74_YEAST", "mass": 69651.0, "length": 642, "protein_name": "Heat shock protein SSA4", "gene_name": "SSA4", "organism": "Yeast", "refseq_name": "Hsp70 family chaperone SSA4", "refseq_ac": "NP_011029", "gene_names_uniprotkb": "SSA4", "gene_names_refseq": "SSA4; YG107", "protein_names_uniprotkb": "Heat shock protein SSA4", "protein_names_refseq": "Hsp70 family chaperone SSA4", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); lymphoma (Disease Ontology:DOID:0060058); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); paranoid schizophrenia (Disease Ontology:DOID:1229); vitiligo (Disease Ontology:DOID:12306); cardiovascular system disease (Disease Ontology:DOID:1287); uveitis (Disease Ontology:DOID:13141); Kawasaki disease (Disease Ontology:DOID:13378); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); systolic heart failure (Disease Ontology:DOID:9651); senile cataract (Disease Ontology:DOID:9669); Meniere's disease (Disease Ontology:DOID:9849); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YER103W); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "14562106;18407956;21126336;2121731;24374639;33491328;9169868", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 44, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DM10", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006457 protein folding;GO:0042026 protein refolding;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22209-1", "uniprot_id": "KIN3_YEAST", "mass": 51203.0, "length": 435, "protein_name": "Serine/threonine-protein kinase KIN3", "gene_name": "KIN3", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase KIN3", "refseq_ac": "NP_009410", "gene_names_uniprotkb": "KIN3; FUN52; NPK1", "gene_names_refseq": "FUN52; KIN3; NPK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase KIN3; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase KIN3", "tax_id": 559292, "disease": "retinitis pigmentosa 67 (Disease Ontology:DOID:0110359); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YAR018C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1495480;1644305;20489023;2199332;24374639;33481703;7731988;7941740", "class_list": "", "function": "This protein is probably a serine/threonine protein kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPM5", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0044732 mitotic spindle pole body", "go_biological_process": "GO:0007059 chromosome segregation;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P22209-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22353-1", "uniprot_id": "RM08_YEAST", "mass": 26945.0, "length": 238, "protein_name": "Large ribosomal subunit protein bL17m", "gene_name": "MRPL8", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL17m MRPL8", "refseq_ac": "NP_012472", "gene_names_uniprotkb": "MRPL8; HRD238; J1125", "gene_names_refseq": "HRD238; MRPL8; bL17m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL17m; 54S ribosomal protein L8, mitochondrial; YmL8", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL17m MRPL8", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL063C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12392552;14562095;14562106;14576278;17322287;2183197;24374639;24675956;25609543;33491328;7762302;8513807;8641269", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWB8", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P22353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22354-1", "uniprot_id": "RM20_YEAST", "mass": 22392.0, "length": 195, "protein_name": "Large ribosomal subunit protein mL58", "gene_name": "MRPL20", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein mL58 MRPL20", "refseq_ac": "NP_013011", "gene_names_uniprotkb": "MRPL20; YKR405", "gene_names_refseq": "MRPL20; mL58", "protein_names_uniprotkb": "Large ribosomal subunit protein mL58; 54S ribosomal protein L20, mitochondrial; YmL20", "protein_names_refseq": "mitochondrial 54S ribosomal protein mL58 MRPL20", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR085C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12392552;14562095;14562106;14576278;2060626;2183197;24374639;24675956;25609543;33229814;8196765;8203164;8513807", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P22354-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22438-1", "uniprot_id": "SYMM_YEAST", "mass": 66734.0, "length": 575, "protein_name": "Methionine--tRNA ligase, mitochondrial", "gene_name": "MSM1", "organism": "Yeast", "refseq_name": "methionine--tRNA ligase MSM1", "refseq_ac": "NP_011687", "gene_names_uniprotkb": "MSM1", "gene_names_refseq": "MSM1", "protein_names_uniprotkb": "Methionine--tRNA ligase, mitochondrial; 6.1.1.10; MetRS; Methionyl-tRNA synthetase", "protein_names_refseq": "methionine--tRNA ligase MSM1", "tax_id": 559292, "disease": "spastic ataxia 3 (Disease Ontology:DOID:0050942); combined oxidative phosphorylation deficiency 25 (Disease Ontology:DOID:0111468); neurodegenerative disease (Disease Ontology:DOID:1289); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YGR171C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;24374639;2645139;9169869", "class_list": "", "function": "Catalyzes the attachment of methionine to tRNA(Met) in the mitochondrion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUV5", "ec_number_list": "6.1.1.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0004825 methionine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006431 methionyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P22438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22470-1", "uniprot_id": "SAN1_YEAST", "mass": 65618.0, "length": 610, "protein_name": "Protein SAN1", "gene_name": "SAN1", "organism": "Yeast", "refseq_name": "ubiquitin-protein ligase SAN1", "refseq_ac": "NP_010427", "gene_names_uniprotkb": "SAN1; YD2943.02C", "gene_names_refseq": "SAN1", "protein_names_uniprotkb": "Protein SAN1", "protein_names_refseq": "ubiquitin-protein ligase SAN1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR143C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;19779198;22106047;23749301;24374639;2471670;30516470;33229814;33481703;33491328;9169867", "class_list": "", "function": "Plays a specific role in mating-type regulation of yeast, by acting post-translationally to control the stability or activity of the SIR4 proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VSC6", "ec_number_list": "", "go_molecular_function": "GO:0031249 denatured protein binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system;GO:1903052 positive regulation of proteolysis involved in protein catabolic process;GO:0051788 response to misfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P22470-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23059-1", "uniprot_id": "NAA38_YEAST", "mass": 9725.0, "length": 88, "protein_name": "N-alpha-acetyltransferase 38, NatC auxiliary subunit", "gene_name": "MAK31", "organism": "Yeast", "refseq_name": "Mak31p", "refseq_ac": "NP_009948", "gene_names_uniprotkb": "MAK31; NAA38; YCR20C-A", "gene_names_refseq": "LSM9; MAK31; NAA38; SMX1", "protein_names_uniprotkb": "N-alpha-acetyltransferase 38, NatC auxiliary subunit; L-A virus GAG protein N-acetyltransferase subunit MAK31; Maintenance of killer protein 31; N-terminal acetyltransferase C complex subunit MAK31; NatC complex subunit MAK31", "protein_names_refseq": "Mak31p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR020C-A)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10504710;11274203;14562106;15077114;1574125;15911569;17322287;21126336;24374639;33139728;33229814;3916862", "class_list": "", "function": "Component of the NatC N-terminal acetyltransferase, which associates with the ribosome to acetylate nascent protein chains in a cotranslational manner (PubMed:11274203, PubMed:15077114, PubMed:33139728). NatC acetylates protein N-termini starting with methionine, followed by a hydrophobic or amphipathic amino acid, with amino acids at positions 3 and 4 also contributing to NatC recognition. The first 4 amino acids of cognate substrates are recognized at the Naa30/MAK3-Naa35/MAK10 interface (PubMed:33139728). NatC-dependent acetylation targets various substrate proteins to specific subcellular sites, including isoform 2 of tRNA-specific methyltransferase Trm1 to the inner nuclear membrane (PubMed:15911569). Catalyzes the acetylation of the N-terminal Met of ARF-like GTPase ARL3, which is required for its Golgi localization via interaction with the Golgi-localized integral membrane protein SYS1, which may serve as a receptor for acetylated ARL3 (PubMed:15077114). Catalyzes the acetylation of the N-terminal Met of L-A virus Gag protein. MAK31 is necessary for the structural stability of L-A double-stranded RNA-containing particles. Necessary for growth at 37 degrees Celsius as well as for maintenance of the killer plasmid (PubMed:11274203)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VR29", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0005688 U6 snRNP;GO:0031417 NatC complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P23059-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23180-1", "uniprot_id": "AIM17_YEAST", "mass": 53135.0, "length": 465, "protein_name": "Probable oxidoreductase AIM17", "gene_name": "AIM17", "organism": "Yeast", "refseq_name": "Aim17p", "refseq_ac": "NP_011842", "gene_names_uniprotkb": "AIM17; FMP12", "gene_names_refseq": "AIM17; FMP12", "protein_names_uniprotkb": "Probable oxidoreductase AIM17; 1.14.11.-; Altered inheritance of mitochondria protein 17, mitochondrial; Found in mitochondrial proteome protein 12", "protein_names_refseq": "Aim17p", "tax_id": 559292, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (sce:YHL021C); (R-SCE-71262)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562095;14562106;19300474;20150421;24374639;3317399;33491328;8091229", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKP4", "ec_number_list": "1.14.11.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051213 dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045329 carnitine biosynthetic process;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P23180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23285-1", "uniprot_id": "CYPB_YEAST", "mass": 22769.0, "length": 205, "protein_name": "Peptidyl-prolyl cis-trans isomerase B", "gene_name": "CPR2", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase CPR2", "refseq_ac": "NP_011924", "gene_names_uniprotkb": "CPR2; CRG; CYP2; SCC2", "gene_names_refseq": "CPR2; CYP2", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase B; 5.2.1.8; Cyclophilin B; Cyclophilin-related protein; PPIase B; Rotamase B", "protein_names_refseq": "peptidylprolyl isomerase CPR2", "tax_id": 559292, "disease": "osteogenesis imperfecta type 9 (Disease Ontology:DOID:0110349)", "pathway": " (sce:YHR057C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17322287;1761234;2183199;24374639;8091229", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL06", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23285-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23369-1", "uniprot_id": "RM25_YEAST", "mass": 18587.0, "length": 157, "protein_name": "Large ribosomal subunit protein mL59", "gene_name": "MRPL25", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein mL59 MRPL25", "refseq_ac": "NP_011590", "gene_names_uniprotkb": "MRPL25; YMR26", "gene_names_refseq": "AFO1; MRPL25; YMR26; mL59", "protein_names_uniprotkb": "Large ribosomal subunit protein mL59; 54S ribosomal protein L25, mitochondrial; YmL25", "protein_names_refseq": "mitochondrial 54S ribosomal protein mL59 MRPL25", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR076C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12392552;14562095;14562106;14576278;2017142;2060626;24374639;24675956;25609543;33491328;9169869", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUK8", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P23369-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23500-1", "uniprot_id": "MRS4_YEAST", "mass": 33307.0, "length": 304, "protein_name": "Mitochondrial RNA-splicing protein MRS4", "gene_name": "MRS4", "organism": "Yeast", "refseq_name": "Fe(2+) transporter", "refseq_ac": "NP_012978", "gene_names_uniprotkb": "MRS4", "gene_names_refseq": "MRS4", "protein_names_uniprotkb": "Mitochondrial RNA-splicing protein MRS4", "protein_names_refseq": "Fe(2+) transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR052C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;1703236;24374639;33481703;8196765", "class_list": "", "function": "MRS4 suppresses a mitochondrial splice defect in the first intron of the COB gene. It may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations). Not essential., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB3", "ec_number_list": "", "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23500-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23501-1", "uniprot_id": "DS1P2_YEAST", "mass": 46488.0, "length": 404, "protein_name": "Dihydrosphingosine 1-phosphate phosphatase YSR3", "gene_name": "YSR3", "organism": "Yeast", "refseq_name": "sphinganine kinase YSR3", "refseq_ac": "NP_012979", "gene_names_uniprotkb": "YSR3; LBP2", "gene_names_refseq": "LBP2; YSR3", "protein_names_uniprotkb": "Dihydrosphingosine 1-phosphate phosphatase YSR3; 3.1.3.-; Long-chain base protein 2; Sphingolipid resistance protein 3", "protein_names_refseq": "sphinganine kinase YSR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR053C); (R-SCE-9845614)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10477278;10563329;10856228;1703236;24374639;25345524;8196765;9353337;9419344", "class_list": "", "function": "Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases (PubMed:10477278, PubMed:10563329, PubMed:10856228, PubMed:9353337, PubMed:9419344). Involved in endocytosis and calcium-mediated signaling (PubMed:10856228)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB4", "ec_number_list": "3.1.3.-", "go_molecular_function": "GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23641-1", "uniprot_id": "MPCP_YEAST", "mass": 32812.0, "length": 311, "protein_name": "Mitochondrial phosphate carrier protein", "gene_name": "MIR1", "organism": "Yeast", "refseq_name": "Mir1p", "refseq_ac": "NP_012611", "gene_names_uniprotkb": "MIR1; J1837", "gene_names_refseq": "MIR1", "protein_names_uniprotkb": "Mitochondrial phosphate carrier protein; Mitochondrial import receptor; PTP; Phosphate transport protein; mPic 1; p32", "protein_names_refseq": "Mir1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR077C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17322287;17761666;1840493;21126336;2170848;24374639;33481703;33491328;8641269;8840504", "class_list": "", "function": "Transport of phosphate groups from the cytosol to the mitochondrial matrix., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWP7", "ec_number_list": "", "go_molecular_function": "GO:0005315 phosphate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0035435 phosphate ion transmembrane transport;GO:1990547 mitochondrial phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P23641-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23748-1", "uniprot_id": "MPIP_YEAST", "mass": 63358.0, "length": 554, "protein_name": "M-phase inducer phosphatase", "gene_name": "MIH1", "organism": "Yeast", "refseq_name": "putative tyrosine protein phosphatase MIH1", "refseq_ac": "NP_013750", "gene_names_uniprotkb": "MIH1; YM9532.01C; YM9973.10C", "gene_names_refseq": "MIH1", "protein_names_uniprotkb": "M-phase inducer phosphatase; 3.1.3.48; Mitosis initiation protein MIH1; Mitotic inducer homolog", "protein_names_refseq": "putative tyrosine protein phosphatase MIH1", "tax_id": 559292, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (sce:YMR036C); (R-SCE-156711); (R-SCE-176187); (R-SCE-5625740); (R-SCE-6804115); (R-SCE-69273); (R-SCE-69601); (R-SCE-75035)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "17563356;18407956;19779198;20489023;21177495;21725298;23749301;24374639;2649252;30516470;32597660;33481703;33491328;34965436;9169872", "class_list": "", "function": "Terminates the cell cycle delay. Reverses the CDC28 phosphorylation catalyzed by SWE1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZL1", "ec_number_list": "2.7.12.1;2.7.11.1;3.1.3.48;2.7.11.13;2.7.11.24;2.7.11.21;3.1.3.16;3.1.3.2", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0110032 positive regulation of G2/MI transition of meiotic cell cycle;GO:0051231 spindle elongation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P23748-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23833-1", "uniprot_id": "SCO1_YEAST", "mass": 33166.0, "length": 295, "protein_name": "Cytochrome c oxidase assembly factor SCO1", "gene_name": "SCO1", "organism": "Yeast", "refseq_name": "Cu-binding protein SCO1", "refseq_ac": "NP_009593", "gene_names_uniprotkb": "SCO1; YBR0406", "gene_names_refseq": "PET161; SCO1", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor SCO1", "protein_names_refseq": "Cu-binding protein SCO1", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 4 (Disease Ontology:DOID:0070493); mitochondrial complex IV deficiency nuclear type 2 (Disease Ontology:DOID:0080357); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); neurodegenerative disease (Disease Ontology:DOID:1289); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); liver disease (Disease Ontology:DOID:409); mitochondrial metabolism disease (Disease Ontology:DOID:700); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YBR037C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10854440;14562106;15199057;16570183;17322287;1944230;24374639;2543907;33491328;7813418", "class_list": "", "function": "Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (COX2) (PubMed:10854440). Involved in transporting copper to the Cu(A) site on COX2 (PubMed:10854440). Binds copper delivered by metallochaperone COX17 (PubMed:15199057, PubMed:16570183)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ37", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P23833-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24000-1", "uniprot_id": "RL24B_YEAST", "mass": 17548.0, "length": 155, "protein_name": "Large ribosomal subunit protein eL24B", "gene_name": "RPL24B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL24 RPL24B", "refseq_ac": "NP_011664", "gene_names_uniprotkb": "RPL24B; G6635; RPL30B", "gene_names_refseq": "RPL24B; RPL30B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL24B; 60S ribosomal protein L24-B; L30; RP29; YL21", "protein_names_refseq": "60S ribosomal protein eL24 RPL24B", "tax_id": 559292, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (sce:YGR148C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11875433;14562095;14562106;15665377;17244705;17322287;17330950;17563356;18407956;20702584;2204809;22096102;22218487;22814378;23749301;24374639;24524803;30516470;32597660;33481703;33491328;8585325;9169869;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBN3;D6VUS9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006413 translational initiation;GO:0006414 translational elongation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P24000-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24521-1", "uniprot_id": "ERG8_YEAST", "mass": 50455.0, "length": 451, "protein_name": "Phosphomevalonate kinase", "gene_name": "ERG8", "organism": "Yeast", "refseq_name": "phosphomevalonate kinase", "refseq_ac": "NP_013947", "gene_names_uniprotkb": "ERG8; YM9959.02", "gene_names_refseq": "ERG8", "protein_names_uniprotkb": "Phosphomevalonate kinase; 2.7.4.2", "protein_names_refseq": "phosphomevalonate kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR220W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;1846667;24374639;32597660;32679672;33481703;33491328;9169872", "class_list": "", "function": "Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:1846667). ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (PubMed:1846667). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W045", "ec_number_list": "2.7.4.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004631 phosphomevalonate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005773 vacuole", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway;GO:0031388 organic acid phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P24521-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24719-1", "uniprot_id": "MEK1_YEAST", "mass": 56850.0, "length": 497, "protein_name": "Meiosis-specific serine/threonine-protein kinase MEK1", "gene_name": "MEK1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase MEK1", "refseq_ac": "NP_014996", "gene_names_uniprotkb": "MEK1; MRE4; O6357", "gene_names_refseq": "MEK1; MRE4", "protein_names_uniprotkb": "Meiosis-specific serine/threonine-protein kinase MEK1; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase MEK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR351C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1741279;1752435;17526735;22072981;24374639;25168012;33491328;8948102;9169874", "class_list": "", "function": "Probable protein kinase required for meiotic recombination., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W346", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0007165 signal transduction;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P24719-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24871-1", "uniprot_id": "CG24_YEAST", "mass": 53853.0, "length": 460, "protein_name": "G2/mitotic-specific cyclin-4", "gene_name": "CLB4", "organism": "Yeast", "refseq_name": "B-type cyclin CLB4", "refseq_ac": "NP_013311", "gene_names_uniprotkb": "CLB4; L8167.3", "gene_names_refseq": "CLB4", "protein_names_uniprotkb": "G2/mitotic-specific cyclin-4", "protein_names_refseq": "B-type cyclin CLB4", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (sce:YLR210W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1387566;1427070;14562106;1849457;20489023;24374639;9169871", "class_list": "", "function": "Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYL1", "ec_number_list": "", "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0001932 regulation of protein phosphorylation;GO:1901673 regulation of mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P24871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25037-1", "uniprot_id": "UBP1_YEAST", "mass": 92769.0, "length": 809, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 1", "gene_name": "UBP1", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP1", "refseq_ac": "NP_010161", "gene_names_uniprotkb": "UBP1; D2250", "gene_names_refseq": "UBP1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 1; 3.4.19.12; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1", "protein_names_refseq": "ubiquitin-specific protease UBP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL122W); (R-SCE-9664873)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "11875433;14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;2050695;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169867", "class_list": "", "function": "Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM8;Q07543", "ec_number_list": "3.4.19.12;2.7.11.1", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P25037-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25038-1", "uniprot_id": "IF2M_YEAST", "mass": 75657.0, "length": 676, "protein_name": "Translation initiation factor IF-2, mitochondrial", "gene_name": "IFM1", "organism": "Yeast", "refseq_name": "translation initiation factor 2", "refseq_ac": "NP_014619", "gene_names_uniprotkb": "IFM1", "gene_names_refseq": "IFM1", "protein_names_uniprotkb": "Translation initiation factor IF-2, mitochondrial; IF-2(Mt); IF-2Mt; IF2(mt)", "protein_names_refseq": "translation initiation factor 2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL023W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;1935960;24374639;9169874", "class_list": "", "function": "Mitochondrial translation initiation factor that promotes binding of formylmethionyl-tRNA to the 30S ribosomal subunits (PubMed:1935960). Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W242;Q12693", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0071944 cell periphery", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0006413 translational initiation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25038-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25039-1", "uniprot_id": "EFGM_YEAST", "mass": 84574.0, "length": 761, "protein_name": "Elongation factor G, mitochondrial", "gene_name": "MEF1", "organism": "Yeast", "refseq_name": "Mef1p", "refseq_ac": "NP_013170", "gene_names_uniprotkb": "MEF1; L2195", "gene_names_refseq": "MEF1", "protein_names_uniprotkb": "Elongation factor G, mitochondrial; EF-Gmt; Elongation factor G 1, mitochondrial; Elongation factor G1; mEF-G 1", "protein_names_refseq": "Mef1p", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 1 (Disease Ontology:DOID:0111474)", "pathway": " (sce:YLR069C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;14576278;17322287;18407956;1935960;20702584;24374639;33481703;33491328;7593000;9169871", "class_list": "", "function": "Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY70;Q6B1Y6;Q99360", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0070125 mitochondrial translational elongation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P25039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25270-1", "uniprot_id": "MRM1_YEAST", "mass": 46387.0, "length": 412, "protein_name": "rRNA methyltransferase 1, mitochondrial", "gene_name": "MRM1", "organism": "Yeast", "refseq_name": "Mrm1p", "refseq_ac": "NP_014844", "gene_names_uniprotkb": "MRM1; PET56", "gene_names_refseq": "MRM1; PET56", "protein_names_uniprotkb": "rRNA methyltransferase 1, mitochondrial; 2.1.1.-; 21S rRNA (guanosine(2270)-2'-O)-methyltransferase; 21S rRNA [Gm2270] 2'-O-methyltransferase; Mitochondrial large ribosomal RNA ribose methylase; Petite colonies protein 56", "protein_names_refseq": "Mrm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR201C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11867542;14562095;14562106;17287358;24374639;3001645;8266080;9169874", "class_list": "", "function": "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 2270 (Gm2270) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This modification seems to be important for the normal accumulation of the mitochondrial large ribosomal subunit., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q8", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity;GO:0003723 RNA binding;GO:0008989 rRNA (guanine-N1-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0000154 rRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P25270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25332-1", "uniprot_id": "RBSK_YEAST", "mass": 36924.0, "length": 333, "protein_name": "Ribokinase", "gene_name": "RBK1", "organism": "Yeast", "refseq_name": "putative ribokinase", "refseq_ac": "NP_009965", "gene_names_uniprotkb": "RBK1; YCR36W; YCR523", "gene_names_refseq": "RBK1", "protein_names_uniprotkb": "Ribokinase; 2.7.1.15; RK", "protein_names_refseq": "putative ribokinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR036W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;1574125;1964349;24374639;33229814", "class_list": "", "function": "Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VR46", "ec_number_list": "2.7.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004747 ribokinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019303 D-ribose catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P25332-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25334-1", "uniprot_id": "CYPR_YEAST", "mass": 35780.0, "length": 318, "protein_name": "Peptidyl-prolyl cis-trans isomerase CPR4", "gene_name": "CPR4", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase family protein CPR4", "refseq_ac": "NP_009995", "gene_names_uniprotkb": "CPR4; CYP4; SCC3; YCR70W", "gene_names_refseq": "CPR4; CYP4; SCC3; YCR070W", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase CPR4; 5.2.1.8; PPIase CPR4; Rotamase", "protein_names_refseq": "peptidylprolyl isomerase family protein CPR4", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR069W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1574125;17322287;1803821;24374639", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VR72;P25658", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25334-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25337-1", "uniprot_id": "BUD31_YEAST", "mass": 18447.0, "length": 157, "protein_name": "Pre-mRNA-splicing factor BUD31", "gene_name": "BUD31", "organism": "Yeast", "refseq_name": "U2 snRNP complex subunit BUD31", "refseq_ac": "NP_009990", "gene_names_uniprotkb": "BUD31; CWC14; YCR63W; YCR903", "gene_names_refseq": "BUD31; CWC14", "protein_names_uniprotkb": "Pre-mRNA-splicing factor BUD31; Bud site selection protein 31; Complexed with CEF1 protein 14", "protein_names_refseq": "U2 snRNP complex subunit BUD31", "tax_id": 559292, "disease": "schistosomiasis (Disease Ontology:DOID:1395)", "pathway": " (sce:YCR063W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11452010;11884590;14562106;1561837;1574125;24374639;33491328", "class_list": "", "function": "Involved in pre-mRNA splicing. Important for bud site selection., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR67", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0005686 U2 snRNP", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000282 cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25338-1", "uniprot_id": "MPO1_YEAST", "mass": 20173.0, "length": 174, "protein_name": "2-hydroxy-palmitic acid dioxygenase MPO1", "gene_name": "MPO1", "organism": "Yeast", "refseq_name": "2-hydroxy-palmitic acid dioxygenase MPO1", "refseq_ac": "NP_011505", "gene_names_uniprotkb": "MPO1; YGL021", "gene_names_refseq": "MPO1", "protein_names_uniprotkb": "2-hydroxy-palmitic acid dioxygenase MPO1; 1.14.18.12; Metabolism of PHS to odd-numbered FA protein 1; Metabolism of phytosphingosine to odd-numbered fatty acids protein 1", "protein_names_refseq": "2-hydroxy-palmitic acid dioxygenase MPO1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL010W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;16847258;1882553;1882554;24374639;25345524;30530523;9169869", "class_list": "", "function": "Dioxygenase that catalyzes the alpha-oxidation of 2-hydroxy fatty acids in an iron-dependent manner (PubMed:30530523). Involved in metabolism of phytosphingosine and is required for proper endoplasmic reticulum stress response (PubMed:25345524, PubMed:30530523)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUC7", "ec_number_list": "1.14.18.12", "go_molecular_function": "GO:0102672 fatty acid alpha-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046521 sphingoid catabolic process;GO:0001561 fatty acid alpha-oxidation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P25338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25339-1", "uniprot_id": "PUF4_YEAST", "mass": 97798.0, "length": 888, "protein_name": "Pumilio homology domain family member 4", "gene_name": "PUF4", "organism": "Yeast", "refseq_name": "Puf4p", "refseq_ac": "NP_011501", "gene_names_uniprotkb": "PUF4; YGL023", "gene_names_refseq": "PUF4; YGL023", "protein_names_uniprotkb": "Pumilio homology domain family member 4", "protein_names_refseq": "Puf4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL014W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562106;15665377;17330950;17563356;18407956;1882553;1909073;19779198;19795423;19823750;22218487;23749301;24374639;32597660;33229814;33481703;33491328;9169869", "class_list": "", "function": "Is not essential for haploid growth, but may affect diploid formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "D6VUC3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010608 post-transcriptional regulation of gene expression;GO:0017148 negative regulation of translation;GO:0008104 intracellular protein localization;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P25339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25345-1", "uniprot_id": "SYNM_YEAST", "mass": 56785.0, "length": 492, "protein_name": "Asparagine--tRNA ligase, mitochondrial", "gene_name": "SLM5", "organism": "Yeast", "refseq_name": "asparagine--tRNA ligase SLM5", "refseq_ac": "NP_009953", "gene_names_uniprotkb": "SLM5; YCR242; YCR24C", "gene_names_refseq": "SLM5", "protein_names_uniprotkb": "Asparagine--tRNA ligase, mitochondrial; 6.1.1.22; AsnRS; Asparaginyl-tRNA synthetase", "protein_names_refseq": "asparagine--tRNA ligase SLM5", "tax_id": 559292, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); combined oxidative phosphorylation deficiency 24 (Disease Ontology:DOID:0111485); autosomal recessive nonsyndromic deafness 94 (Disease Ontology:DOID:0111641)", "pathway": " (sce:YCR024C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;1574125;1574926;24374639;9030748", "class_list": "", "function": "Catalyzes the attachment of asparagine to tRNA(Asn) in the mitochondrion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR33", "ec_number_list": "6.1.1.22", "go_molecular_function": "GO:0005524 ATP binding;GO:0003676 nucleic acid binding;GO:0004816 asparagine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070145 mitochondrial asparaginyl-tRNA aminoacylation;GO:0006421 asparaginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25345-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25348-1", "uniprot_id": "RM32_YEAST", "mass": 21437.0, "length": 183, "protein_name": "Large ribosomal subunit protein bL32m", "gene_name": "MRPL32", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL32m MRPL32", "refseq_ac": "NP_009929", "gene_names_uniprotkb": "MRPL32; YCR041; YCR3W", "gene_names_refseq": "MRPL32; bL32m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL32m; 54S ribosomal protein L32, mitochondrial; YmL32", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL32m MRPL32", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR003W); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14562095;14562106;14576278;1574125;1580102;16239145;17322287;1872033;2060626;21610694;24374639;24675956;25609543;28154081", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR13", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P25348-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25349-1", "uniprot_id": "YCP4_YEAST", "mass": 26350.0, "length": 247, "protein_name": "Flavoprotein-like protein YCP4", "gene_name": "YCP4", "organism": "Yeast", "refseq_name": "flavodoxin-like fold family protein", "refseq_ac": "NP_009930", "gene_names_uniprotkb": "YCP4; YCR042; YCR4C", "gene_names_refseq": "YCP4", "protein_names_uniprotkb": "Flavoprotein-like protein YCP4", "protein_names_refseq": "flavodoxin-like fold family protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR004C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14576278;1574125;1580102;16751107;19064668;21126336;24374639;32597660;33491328", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR14", "ec_number_list": "", "go_molecular_function": "GO:0003955 NAD(P)H dehydrogenase (quinone) activity;GO:0010181 FMN binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0160020 positive regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P25349-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25356-1", "uniprot_id": "BPH1_YEAST", "mass": 250872.0, "length": 2167, "protein_name": "Beige protein homolog 1", "gene_name": "BPH1", "organism": "Yeast", "refseq_name": "Bph1p", "refseq_ac": "NP_009961", "gene_names_uniprotkb": "BPH1; YCR32W; YCR591; YCR601", "gene_names_refseq": "BPH1", "protein_names_uniprotkb": "Beige protein homolog 1", "protein_names_refseq": "Bph1p", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary autosomal dominant microcephaly 18 (Disease Ontology:DOID:0070295); exfoliation syndrome (Disease Ontology:DOID:13641); platelet storage pool deficiency (Disease Ontology:DOID:2223); Chediak-Higashi syndrome (Disease Ontology:DOID:2935)", "pathway": " (sce:YCR032W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15296494;1574125;1776366;1837415;1872032;22106047;24374639;33491328", "class_list": "", "function": "May be involved in protein sorting and cell wall formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR42;Q02396;Q07348", "ec_number_list": "", "go_molecular_function": "GO:0016230 sphingomyelin phosphodiesterase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005770 late endosome;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0006497 protein lipidation;GO:0009268 response to pH;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P25356-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25360-1", "uniprot_id": "PHO87_YEAST", "mass": 102540.0, "length": 923, "protein_name": "Inorganic phosphate transporter PHO87", "gene_name": "PHO87", "organism": "Yeast", "refseq_name": "SPX domain-containing inorganic phosphate transporter", "refseq_ac": "NP_009966", "gene_names_uniprotkb": "PHO87; YCR37C; YCR524", "gene_names_refseq": "PHO87", "protein_names_uniprotkb": "Inorganic phosphate transporter PHO87", "protein_names_refseq": "SPX domain-containing inorganic phosphate transporter", "tax_id": 559292, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667); developmental and epileptic encephalopathy 25 (Disease Ontology:DOID:0080453); Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YCR037C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12872131;14562106;1574125;16847258;1964349;19779198;21143198;22106047;23749301;24374639;33491328;8598055", "class_list": "", "function": "Low-affinity phosphate transporter involved in the control of cellular phosphate levels., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VR47", "ec_number_list": "", "go_molecular_function": "GO:0005315 phosphate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006817 phosphate ion transport;GO:0006797 polyphosphate metabolic process;GO:0097080 plasma membrane selenite transport;GO:2000185 regulation of phosphate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P25360-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25365-1", "uniprot_id": "SED4_YEAST", "mass": 114079.0, "length": 1065, "protein_name": "Putative guanine nucleotide-exchange factor SED4", "gene_name": "SED4", "organism": "Yeast", "refseq_name": "GTPase-activating protein SED4", "refseq_ac": "NP_009993", "gene_names_uniprotkb": "SED4; YCR67C; YCR901", "gene_names_refseq": "SED4", "protein_names_uniprotkb": "Putative guanine nucleotide-exchange factor SED4", "protein_names_refseq": "GTPase-activating protein SED4", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR067C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11168590;1327759;14562095;1561837;1574125;17322287;18407956;19779198;24374639;7593162;9880808", "class_list": "", "function": "Putative guanine nucleotide-exchange factor (GEF) involved in the formation or budding of transport vesicles from the ER. Positive regulator of SAR1 probably through inhibition of the GTPase activation by SEC23., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VR70", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0003400 regulation of COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P25365-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25371-1", "uniprot_id": "ADP1_YEAST", "mass": 117231.0, "length": 1049, "protein_name": "Probable ATP-dependent permease", "gene_name": "ADP1", "organism": "Yeast", "refseq_name": "putative ATP-dependent permease ADP1", "refseq_ac": "NP_009937", "gene_names_uniprotkb": "ADP1; YCR105; YCR11C", "gene_names_refseq": "ADP1", "protein_names_uniprotkb": "Probable ATP-dependent permease", "protein_names_refseq": "putative ATP-dependent permease ADP1", "tax_id": 559292, "disease": "secondary hyperparathyroidism (Disease Ontology:DOID:12466); gout (Disease Ontology:DOID:13189); erythropoietic protoporphyria (Disease Ontology:DOID:13270); status epilepticus (Disease Ontology:DOID:1824); hyperuricemia (Disease Ontology:DOID:1920); breast carcinoma (Disease Ontology:DOID:3459); toxic encephalopathy (Disease Ontology:DOID:3602); renal cell carcinoma (Disease Ontology:DOID:4450); B-cell lymphoma (Disease Ontology:DOID:707); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YCR011C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562095;14562106;1574125;1626432;16847258;17322287;17563356;1789009;18407956;19779198;20702584;21177495;22218487;23749301;24374639;24909858;32597660;33481703;33491328", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VR20", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P25371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25379-1", "uniprot_id": "STDH_YEAST", "mass": 39301.0, "length": 360, "protein_name": "Catabolic L-serine/threonine dehydratase", "gene_name": "CHA1", "organism": "Yeast", "refseq_name": "L-serine/L-threonine ammonia-lyase CHA1", "refseq_ac": "NP_001018030", "gene_names_uniprotkb": "CHA1; YCL64C", "gene_names_refseq": "CHA1", "protein_names_uniprotkb": "Catabolic L-serine/threonine dehydratase; L-serine deaminase; L-threonine deaminase", "protein_names_refseq": "L-serine/L-threonine ammonia-lyase CHA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL064C); (R-SCE-8849175); (R-SCE-977347)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14562095;14562106;1574125;1628804;16823961;22814378;24374639", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQV4", "ec_number_list": "4.3.1.19;4.3.1.17", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003941 L-serine ammonia-lyase activity;GO:0004794 threonine deaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006567 L-threonine catabolic process;GO:0006565 L-serine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25379-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25381-1", "uniprot_id": "RRT12_YEAST", "mass": 55068.0, "length": 491, "protein_name": "Subtilase-type proteinase RRT12", "gene_name": "RRT12", "organism": "Yeast", "refseq_name": "Rrt12p", "refseq_ac": "NP_009974", "gene_names_uniprotkb": "RRT12; OSW3; YCR45C", "gene_names_refseq": "OSW3; RRT12", "protein_names_uniprotkb": "Subtilase-type proteinase RRT12; 3.4.21.-; Outer spore wall protein 3; Regulator of rDNA transcription protein 12", "protein_names_refseq": "Rrt12p", "tax_id": 559292, "disease": "familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390)", "pathway": " (sce:YCR045C); (R-SCE-8866427); (R-SCE-8964038)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1574125;19270272;19756047;19779569;24374639", "class_list": "", "function": "Subtilisin-related protease involved in the formation of a protective dityrosine layer required for spore wall assembly. Identified in a screen for mutants with increased levels of rDNA transcription., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VR54", "ec_number_list": "3.4.21.48;3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005619 ascospore wall", "go_biological_process": "GO:0006508 proteolysis;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25390-1", "uniprot_id": "SSK22_YEAST", "mass": 152718.0, "length": 1331, "protein_name": "Serine/threonine-protein kinase SSK22", "gene_name": "SSK22", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase kinase kinase SSK22", "refseq_ac": "NP_009998", "gene_names_uniprotkb": "SSK22; YCR73C", "gene_names_refseq": "SSK22", "protein_names_uniprotkb": "Serine/threonine-protein kinase SSK22; 2.7.11.1; MAP kinase kinase kinase SSK22; Suppressor of sensor kinase 22", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase SSK22", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR073C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;1574125;19779198;20489023;21177495;23749301;24374639;33481703;33491328;7624781", "class_list": "", "function": "Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR75", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051403 stress-activated MAPK cascade;GO:0038066 p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P25390-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25559-1", "uniprot_id": "DCC1_YEAST", "mass": 44074.0, "length": 380, "protein_name": "Sister chromatid cohesion protein DCC1", "gene_name": "DCC1", "organism": "Yeast", "refseq_name": "Dcc1p", "refseq_ac": "NP_009913", "gene_names_uniprotkb": "DCC1; YCL16C", "gene_names_refseq": "DCC1", "protein_names_uniprotkb": "Sister chromatid cohesion protein DCC1; Defective in sister chromatid cohesion protein 1", "protein_names_refseq": "Dcc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL016C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11389843;14562106;1574125;15964801;18407956;24374639;33491328", "class_list": "", "function": "Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQZ8;Q8NIM7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006260 DNA replication;GO:0007064 mitotic sister chromatid cohesion;GO:0034088 maintenance of mitotic sister chromatid cohesion;GO:0034398 telomere tethering at nuclear periphery;GO:0035753 maintenance of DNA trinucleotide repeats", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25559-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25560-1", "uniprot_id": "RER1_YEAST", "mass": 22270.0, "length": 188, "protein_name": "Protein RER1", "gene_name": "RER1", "organism": "Yeast", "refseq_name": "protein retrieval receptor", "refseq_ac": "NP_009925", "gene_names_uniprotkb": "RER1; YCL1W", "gene_names_refseq": "RER1", "protein_names_uniprotkb": "Protein RER1; Retention of ER proteins 1", "protein_names_refseq": "protein retrieval receptor", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL001W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;1574125;16847258;21126336;24374639;33491328;8367481;8589449;9275186", "class_list": "", "function": "Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Required for correct localization of SEC12, SEC71 and SEC63 in the endoplasmic reticulum., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR09", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0030137 COPI-coated vesicle;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P25560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25566-1", "uniprot_id": "MXR2_YEAST", "mass": 19279.0, "length": 168, "protein_name": "Peptide methionine sulfoxide reductase 2", "gene_name": "MXR2", "organism": "Yeast", "refseq_name": "peptide-methionine (R)-S-oxide reductase", "refseq_ac": "NP_009897", "gene_names_uniprotkb": "MXR2; MSRB; YCL33C", "gene_names_refseq": "MXR2", "protein_names_uniprotkb": "Peptide methionine sulfoxide reductase 2; 1.8.4.12", "protein_names_refseq": "peptide-methionine (R)-S-oxide reductase", "tax_id": 559292, "disease": "autosomal recessive nonsyndromic deafness 74 (Disease Ontology:DOID:0110523)", "pathway": " (sce:YCL033C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;15141092;1574125;19202110;24374639;33491328", "class_list": "", "function": "Methionine-R-sulfoxide reductase which catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. Protects iron-sulfur clusters from oxidative inactivation along with MXR1. Involved in the regulation of lifespan., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQY2", "ec_number_list": "1.8.4.12", "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25566-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25578-1", "uniprot_id": "PGPS1_YEAST", "mass": 59370.0, "length": 521, "protein_name": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase", "gene_name": "PGS1", "organism": "Yeast", "refseq_name": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase", "refseq_ac": "NP_009923", "gene_names_uniprotkb": "PGS1; PEL1; YCL003W; YCL3W; YCL4W", "gene_names_refseq": "PEL1; PGS1; YCL003W", "protein_names_uniprotkb": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; 2.7.8.5; PGP synthase; Phosphatidylglycerophosphate synthase", "protein_names_refseq": "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL004W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1574125;18407956;24374639;8252640;8553693;9545322;9799363", "class_list": "", "function": "Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR07;O93974;P25570;P87011", "ec_number_list": "2.7.8.5", "go_molecular_function": "GO:0005524 ATP binding;GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25578-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25583-1", "uniprot_id": "MET14_YEAST", "mass": 38672.0, "length": 335, "protein_name": "Karyogamy protein KAR4", "gene_name": "KAR4", "organism": "Yeast", "refseq_name": "Kar4p", "refseq_ac": "NP_009876", "gene_names_uniprotkb": "KAR4; YCL432; YCL55W", "gene_names_refseq": "KAR4", "protein_names_uniprotkb": "Karyogamy protein KAR4", "protein_names_refseq": "Kar4p", "tax_id": 559292, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292)", "pathway": " (sce:YCL055W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1441748;14562095;14562106;1574125;18407956;19520826;19795423;19823750;24374639;33491328;36930734;8754797", "class_list": "", "function": "Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation (PubMed:36930734, PubMed:8754797). May assist STE12 in the pheromone-dependent expression of KAR3 and CIK1 (PubMed:8754797)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQW2", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016556 mRNA modification;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051321 meiotic cell cycle;GO:0000742 karyogamy involved in conjugation with cellular fusion;GO:2000221 negative regulation of pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P25583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25587-1", "uniprot_id": "LDB16_YEAST", "mass": 29024.0, "length": 256, "protein_name": "Protein LDB16", "gene_name": "LDB16", "organism": "Yeast", "refseq_name": "Ldb16p", "refseq_ac": "NP_009922", "gene_names_uniprotkb": "LDB16; YCL5W", "gene_names_refseq": "LDB16", "protein_names_uniprotkb": "Protein LDB16; Low dye-binding protein 16", "protein_names_refseq": "Ldb16p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL005W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562095;14562106;1574125;15993632;16847258;17287358;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;32597660;33481703;33491328", "class_list": "", "function": "May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR06;Q8NIM5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0019216 regulation of lipid metabolic process;GO:0034389 lipid droplet organization;GO:0090155 negative regulation of sphingolipid biosynthetic process;GO:0140042 lipid droplet formation;GO:1990044 protein localization to lipid droplet", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P25587-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25594-1", "uniprot_id": "VBA3_YEAST", "mass": 50225.0, "length": 458, "protein_name": "Vacuolar basic amino acid transporter 3", "gene_name": "VBA3", "organism": "Yeast", "refseq_name": "basic amino acid transporter", "refseq_ac": "NP_009864", "gene_names_uniprotkb": "VBA3; YCL69W", "gene_names_refseq": "VBA3", "protein_names_uniprotkb": "Vacuolar basic amino acid transporter 3", "protein_names_refseq": "basic amino acid transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL069W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15572352;1574125;16847258;24374639", "class_list": "", "function": "Transporter required for vacuolar uptake of histidine and lysine., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQV0", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0015802 basic amino acid transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25594-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25596-1", "uniprot_id": "GEX1_YEAST", "mass": 68921.0, "length": 615, "protein_name": "Glutathione exchanger 1", "gene_name": "GEX1", "organism": "Yeast", "refseq_name": "glutathione exchanger", "refseq_ac": "NP_009863", "gene_names_uniprotkb": "GEX1; YCL73C", "gene_names_refseq": "GEX1", "protein_names_uniprotkb": "Glutathione exchanger 1", "protein_names_refseq": "glutathione exchanger", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL073C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14561723;1574125;16847258;21126336;21490148;24374639;8771713", "class_list": "", "function": "Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQU9;P25597;P25599;P87002;Q8NIN5", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0034634 glutathione transmembrane transporter activity;GO:0015343 siderophore-iron transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0034775 glutathione transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25621-1", "uniprot_id": "FEN2_YEAST", "mass": 58256.0, "length": 512, "protein_name": "Pantothenate transporter FEN2", "gene_name": "FEN2", "organism": "Yeast", "refseq_name": "Fen2p", "refseq_ac": "NP_009957", "gene_names_uniprotkb": "FEN2; YCR28C", "gene_names_refseq": "FEN2", "protein_names_uniprotkb": "Pantothenate transporter FEN2; Fenpropimorph resistance protein 2", "protein_names_refseq": "Fen2p", "tax_id": 559292, "disease": "autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); lysosomal storage disease (Disease Ontology:DOID:3211); sialuria (Disease Ontology:DOID:3659)", "pathway": " (sce:YCR028C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10373490;1332309;14562106;1574125;16847258;23749301;24374639;32597660;33481703;8313894;8771708", "class_list": "", "function": "Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR38", "ec_number_list": "", "go_molecular_function": "GO:0015233 pantothenate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015887 pantothenate transmembrane transport;GO:0006897 endocytosis;GO:0098717 pantothenate import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P25621-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25625-1", "uniprot_id": "PER1_YEAST", "mass": 42541.0, "length": 357, "protein_name": "Protein PER1", "gene_name": "PER1", "organism": "Yeast", "refseq_name": "Per1p", "refseq_ac": "NP_009973", "gene_names_uniprotkb": "PER1; COS16; YCR44C", "gene_names_refseq": "COS16; PER1", "protein_names_uniprotkb": "Protein PER1; Protein processing in the ER protein 1", "protein_names_refseq": "Per1p", "tax_id": 559292, "disease": "hyperphosphatasia with impaired intellectual development syndrome (Disease Ontology:DOID:0070431); hyperphosphatasia with impaired intellectual development syndrome 4 (Disease Ontology:DOID:0070436); chronic asthma (Disease Ontology:DOID:0080809); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (sce:YCR044C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;1574125;16847258;17021251;24374639", "class_list": "", "function": "Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for efficient transport of GPI-anchor proteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VR53", "ec_number_list": "", "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0030026 intracellular manganese ion homeostasis;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25625-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25626-1", "uniprot_id": "IMG1_YEAST", "mass": 19394.0, "length": 169, "protein_name": "Large ribosomal subunit protein bL19m", "gene_name": "IMG1", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL19m IMG1", "refseq_ac": "NP_009975", "gene_names_uniprotkb": "IMG1; PETCR46; YCR46C", "gene_names_refseq": "IMG1; bL19m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL19m; 54S ribosomal protein IMG1, mitochondrial; Integrity of mitochondrial genome protein 1; PetCR46", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL19m IMG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR046C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12392552;14562095;14562106;14576278;1574125;17322287;24374639;24675956;25609543;33491328;8771712", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543). bL19m is essential for respiration (PubMed:8771712)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR55", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P25626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25628-1", "uniprot_id": "ARE1_YEAST", "mass": 71613.0, "length": 610, "protein_name": "Sterol O-acyltransferase 1", "gene_name": "ARE1", "organism": "Yeast", "refseq_name": "sterol acyltransferase", "refseq_ac": "NP_009978", "gene_names_uniprotkb": "ARE1; SAT2; YCR48W", "gene_names_refseq": "ARE1; SAT2", "protein_names_uniprotkb": "Sterol O-acyltransferase 1; 2.3.1.-; Sterol-ester synthase 1", "protein_names_refseq": "sterol acyltransferase", "tax_id": 559292, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (sce:YCR048W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10672016;1574125;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;22218487;23749301;24374639;24909858;30516470;32597660;33481703;33491328;8650549", "class_list": "", "function": "Sterol O-acyltransferase that catalyzes the formation of stery esters., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR57", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0034737 ergosterol O-acyltransferase activity;GO:0034738 lanosterol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016125 sterol metabolic process;GO:0008204 ergosterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P25628-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26343-1", "uniprot_id": "DAL80_YEAST", "mass": 30166.0, "length": 269, "protein_name": "Nitrogen regulatory protein DAL80", "gene_name": "DAL80", "organism": "Yeast", "refseq_name": "Dal80p", "refseq_ac": "NP_012959", "gene_names_uniprotkb": "DAL80; UGA43", "gene_names_refseq": "DAL80; UGA43", "protein_names_uniprotkb": "Nitrogen regulatory protein DAL80; Regulatory protein UGA43", "protein_names_refseq": "Dal80p", "tax_id": 559292, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 21 (Disease Ontology:DOID:0111947); pre-eclampsia (Disease Ontology:DOID:10591); aplastic anemia (Disease Ontology:DOID:12449); depressive disorder (Disease Ontology:DOID:1596); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myeloid leukemia (Disease Ontology:DOID:8692); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YKR034W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1525858;17563356;1944286;24374639;8196765", "class_list": "", "function": "Negative regulator of multiple nitrogen catabolic genes including the allantoin pathway genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX97", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042128 nitrate assimilation;GO:0090295 nitrogen catabolite repression of transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P26343-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26725-1", "uniprot_id": "YUR1_YEAST", "mass": 50836.0, "length": 428, "protein_name": "Probable mannosyltransferase YUR1", "gene_name": "YUR1", "organism": "Yeast", "refseq_name": "mannosyltransferase YUR1", "refseq_ac": "NP_012396", "gene_names_uniprotkb": "YUR1; J0657", "gene_names_refseq": "YUR1", "protein_names_uniprotkb": "Probable mannosyltransferase YUR1; 2.4.1.-", "protein_names_refseq": "mannosyltransferase YUR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL139C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;2041753;24374639;8641269;8813765", "class_list": "", "function": "Possible glycosyltransferase involved in N-linked glycosylation. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VW45", "ec_number_list": "", "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P26725-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26798-1", "uniprot_id": "INO2_YEAST", "mass": 34234.0, "length": 304, "protein_name": "Protein INO2", "gene_name": "INO2", "organism": "Yeast", "refseq_name": "Ino2p", "refseq_ac": "NP_010408", "gene_names_uniprotkb": "INO2; DIE1; SCS1; YD9727.18C", "gene_names_refseq": "DIE1; INO2; SCS1", "protein_names_uniprotkb": "Protein INO2", "protein_names_refseq": "Ino2p", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDR123C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;1620625;17322287;24374639;7565092;8125958;8188619;9169867", "class_list": "", "function": "Positive regulatory factor required for depression of the coregulated phospholipid biosynthetic enzymes. Also involved in the expression of ITR1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSA9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P26798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27344-1", "uniprot_id": "DPB3_YEAST", "mass": 22665.0, "length": 201, "protein_name": "DNA polymerase epsilon subunit C", "gene_name": "DPB3", "organism": "Yeast", "refseq_name": "DNA polymerase epsilon noncatalytic subunit", "refseq_ac": "NP_009837", "gene_names_uniprotkb": "DPB3; YBR2015", "gene_names_refseq": "DPB3", "protein_names_uniprotkb": "DNA polymerase epsilon subunit C; DNA polymerase II subunit C", "protein_names_refseq": "DNA polymerase epsilon noncatalytic subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR278W); (R-SCE-6782135); (R-SCE-68952); (R-SCE-68962)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "11024162;12124389;12571237;14562106;17287358;17330950;17563356;18407956;1923754;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33481703;33491328;7813418;8091861", "class_list": "", "function": "As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS3", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0008623 CHRAC", "go_biological_process": "GO:0006272 leading strand elongation;GO:0042276 error-prone translesion synthesis;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P27344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27929-1", "uniprot_id": "NAM9_YEAST", "mass": 56356.0, "length": 486, "protein_name": "Small ribosomal subunit protein uS4m", "gene_name": "NAM9", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein uS4m NAM9", "refseq_ac": "NP_014262", "gene_names_uniprotkb": "NAM9; MNA6; N1211; N1840", "gene_names_refseq": "MNA6; NAM9; uS4m", "protein_names_uniprotkb": "Small ribosomal subunit protein uS4m; 37S ribosomal protein NAM9, mitochondrial; Nuclear accommodation of mitochondria protein 9", "protein_names_refseq": "mitochondrial 37S ribosomal protein uS4m NAM9", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL137C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10529174;11278769;12392552;14562095;14562106;14576278;1729612;19684113;24374639;25609543;28154081;7557422;8619318;9169873", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W145", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P27929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28006-1", "uniprot_id": "GAC1_YEAST", "mass": 88533.0, "length": 793, "protein_name": "Serine/threonine-protein phosphatase 1 regulatory subunit GAC1", "gene_name": "GAC1", "organism": "Yeast", "refseq_name": "protein phosphatase regulator GAC1", "refseq_ac": "NP_014821", "gene_names_uniprotkb": "GAC1", "gene_names_refseq": "GAC1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 1 regulatory subunit GAC1", "protein_names_refseq": "protein phosphatase regulator GAC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR178C); (R-SCE-3322077)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1310938;19779198;22814378;23749301;24374639;33491328;9169874", "class_list": "", "function": "Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2N4;Q08551", "ec_number_list": "", "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0005979 regulation of glycogen biosynthetic process;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28006-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28239-1", "uniprot_id": "IPYR2_YEAST", "mass": 35573.0, "length": 310, "protein_name": "Inorganic pyrophosphatase, mitochondrial", "gene_name": "PPA2", "organism": "Yeast", "refseq_name": "inorganic diphosphatase PPA2", "refseq_ac": "NP_013994", "gene_names_uniprotkb": "PPA2; IPP2; YM8156.09", "gene_names_refseq": "IPP2; PPA2", "protein_names_uniprotkb": "Inorganic pyrophosphatase, mitochondrial; 3.6.1.1; PPase; Pyrophosphate phospho-hydrolase", "protein_names_refseq": "inorganic diphosphatase PPA2", "tax_id": 559292, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); myocarditis (Disease Ontology:DOID:820)", "pathway": " (sce:YMR267W); (R-SCE-379716); (R-SCE-71737)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1321599;14562106;1648084;24374639;33491328;9169872", "class_list": "", "function": "Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W093", "ec_number_list": "3.6.1.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004427 inorganic diphosphate phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28273-1", "uniprot_id": "OPLA_YEAST", "mass": 140428.0, "length": 1286, "protein_name": "5-oxoprolinase", "gene_name": "OXP1", "organism": "Yeast", "refseq_name": "5-oxoprolinase", "refseq_ac": "NP_012707", "gene_names_uniprotkb": "OXP1", "gene_names_refseq": "OXP1", "protein_names_uniprotkb": "5-oxoprolinase; 3.5.2.9; 5-OPase; 5-oxo-L-prolinase; Pyroglutamase", "protein_names_refseq": "5-oxoprolinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL215C); (R-SCE-174403)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562095;14562106;1511880;18407956;19779198;20349993;20402795;22814378;23749301;24374639;30516470;32597660;33481703;33491328;7941750;8196765", "class_list": "", "function": "Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWY8;O60212", "ec_number_list": "3.5.2.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P28273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28584-1", "uniprot_id": "TRK2_YEAST", "mass": 101087.0, "length": 889, "protein_name": "Low-affinity potassium transport protein", "gene_name": "TRK2", "organism": "Yeast", "refseq_name": "Trk2p", "refseq_ac": "NP_012976", "gene_names_uniprotkb": "TRK2; RPD2", "gene_names_refseq": "RPD2; TRK2", "protein_names_uniprotkb": "Low-affinity potassium transport protein", "protein_names_refseq": "Trk2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR050W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16847258;2072919;24374639;33491328;8196765", "class_list": "", "function": "This protein is required for low-affinity potassium transport., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB1", "ec_number_list": "", "go_molecular_function": "GO:0015079 potassium ion transmembrane transporter activity;GO:0140107 high-affinity potassium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0006874 intracellular calcium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28777-1", "uniprot_id": "AROC_YEAST", "mass": 40838.0, "length": 376, "protein_name": "Chorismate synthase ARO2", "gene_name": "ARO2", "organism": "Yeast", "refseq_name": "bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2", "refseq_ac": "NP_011367", "gene_names_uniprotkb": "ARO2", "gene_names_refseq": "ARO2", "protein_names_uniprotkb": "Chorismate synthase ARO2; 1.5.1.38; 4.2.3.5; 5-enolpyruvylshikimate-3-phosphate phospholyase; Aromatic amino acid requiring protein 2", "protein_names_refseq": "bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL148W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;14573601;1837329;18407956;19779198;21126336;22814378;22842922;23749301;24374639;32597660;33481703;33491328;361708;8971708;9046099;9169869", "class_list": "", "function": "Bifunctional chorismate synthase and flavin reductase that catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is the last common intermediate in the synthesis of the three aromatic amino acids phenylalanine, tyrosine and tryptophan (PubMed:8971708). Also acts as a flavin reductase (FR) able to generate reduced flavin mononucleotide in the presence of NADPH (PubMed:8971708)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VU01", "ec_number_list": "4.2.3.5;1.5.1.38;1.5.1.39", "go_molecular_function": "GO:0010181 FMN binding;GO:0042602 riboflavin reductase (NADPH) activity;GO:0004107 chorismate synthase activity;GO:0052873 FMN reductase (NADPH) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008652 amino acid biosynthetic process;GO:0009073 aromatic amino acid family biosynthetic process;GO:0009423 chorismate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P28777-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28789-1", "uniprot_id": "HEM3_YEAST", "mass": 36675.0, "length": 327, "protein_name": "Porphobilinogen deaminase", "gene_name": "HEM3", "organism": "Yeast", "refseq_name": "hydroxymethylbilane synthase", "refseq_ac": "NP_010076", "gene_names_uniprotkb": "HEM3; D1057", "gene_names_refseq": "HEM3; OLE2", "protein_names_uniprotkb": "Porphobilinogen deaminase; 2.5.1.61; HMBS; Hydroxymethylbilane synthase; PBG; Pre-uroporphyrinogen synthase", "protein_names_refseq": "hydroxymethylbilane synthase", "tax_id": 559292, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); cancer (Disease Ontology:DOID:162); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); seminoma (Disease Ontology:DOID:4440); liver carcinoma (Disease Ontology:DOID:686)", "pathway": " (sce:YDL205C); (R-SCE-189451)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;1508149;15905473;19795423;19823750;21126336;22814378;24374639;33491328;9169867", "class_list": "", "function": "Catalyzes the tetrapolymerization of the monopyrrole porphobilinogen (PBG) into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRE9;Q2VQW9", "ec_number_list": "2.5.1.61", "go_molecular_function": "GO:0004418 hydroxymethylbilane synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P28789-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30606-1", "uniprot_id": "ITR2_YEAST", "mass": 66710.0, "length": 609, "protein_name": "Myo-inositol transporter 2", "gene_name": "ITR2", "organism": "Yeast", "refseq_name": "myo-inositol transporter ITR2", "refseq_ac": "NP_014538", "gene_names_uniprotkb": "ITR2; HRB612", "gene_names_refseq": "HRB612; ITR2", "protein_names_uniprotkb": "Myo-inositol transporter 2", "protein_names_refseq": "myo-inositol transporter ITR2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL103W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12748633;14562106;16233524;16847258;19779198;2040626;22814378;24374639;33491328;7502582;9169874", "class_list": "", "function": "Minor transporter for myo-inositol., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1W5", "ec_number_list": "", "go_molecular_function": "GO:0005366 myo-inositol:proton symporter activity;GO:0005365 myo-inositol transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015798 myo-inositol transport;GO:1904679 myo-inositol import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P30606-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31334-1", "uniprot_id": "RM09_YEAST", "mass": 29790.0, "length": 269, "protein_name": "Large ribosomal subunit protein uL3m", "gene_name": "MRPL9", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL3m MRPL9", "refseq_ac": "NP_011736", "gene_names_uniprotkb": "MRPL9; G8520", "gene_names_refseq": "MRPL9; uL3m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3m; 54S ribosomal protein L9, mitochondrial; YmL9", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL3m MRPL9", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 9 (Disease Ontology:DOID:0111472)", "pathway": " (sce:YGR220C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;14576278;1597181;17322287;24374639;24675956;25609543;3060376;33491328;8701610;9169869", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV02", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P31334-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31379-1", "uniprot_id": "LDS1_YEAST", "mass": 37050.0, "length": 325, "protein_name": "Outer spore wall protein LDS1", "gene_name": "LDS1", "organism": "Yeast", "refseq_name": "Lds1p", "refseq_ac": "NP_009384", "gene_names_uniprotkb": "LDS1; YAL003", "gene_names_refseq": "LDS1", "protein_names_uniprotkb": "Outer spore wall protein LDS1; Lipid droplets in sporulation protein 1", "protein_names_refseq": "Lds1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL018C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1561836;16847258;23966878;24374639;24390141;7731988;8458570", "class_list": "", "function": "Involved in spore wall assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005619 ascospore wall;GO:0005628 prospore membrane", "go_biological_process": "GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P31379-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31381-1", "uniprot_id": "FUN26_YEAST", "mass": 58317.0, "length": 517, "protein_name": "Nucleoside transporter FUN26", "gene_name": "FUN26", "organism": "Yeast", "refseq_name": "nucleoside transmembrane transporter FUN26", "refseq_ac": "NP_009380", "gene_names_uniprotkb": "FUN26", "gene_names_refseq": "FUN26", "protein_names_uniprotkb": "Nucleoside transporter FUN26", "protein_names_refseq": "nucleoside transmembrane transporter FUN26", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); histiocytosis-lymphadenopathy plus syndrome (Disease Ontology:DOID:0111278); brain ischemia (Disease Ontology:DOID:2316); diffuse idiopathic skeletal hyperostosis (Disease Ontology:DOID:6652)", "pathway": " (sce:YAL022C); (R-SCE-83936); (R-SCE-9748787); (R-SCE-9755088)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10827169;14562106;17330950;18407956;19779198;20702584;21126336;24374639;32597660;33481703;33491328;7731988;8458570", "class_list": "", "function": "Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPJ6", "ec_number_list": "", "go_molecular_function": "GO:0015205 nucleobase transmembrane transporter activity;GO:0005337 nucleoside transmembrane transporter activity;GO:0034257 nicotinamide riboside transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015858 nucleoside transport;GO:0055085 transmembrane transport;GO:0034258 nicotinamide riboside transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P31381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31386-1", "uniprot_id": "ATS1_YEAST", "mass": 36467.0, "length": 333, "protein_name": "Protein KTI13", "gene_name": "ATS1", "organism": "Yeast", "refseq_name": "Ats1p", "refseq_ac": "NP_009382", "gene_names_uniprotkb": "ATS1; FUN28; KTI13; YAL006", "gene_names_refseq": "ATS1; DPH8; FUN28; KTI13", "protein_names_uniprotkb": "Protein KTI13; Alpha-tubulin suppressor 1; Kluyveromyces lactis toxin-insensitive protein 13", "protein_names_refseq": "Ats1p", "tax_id": 559292, "disease": "atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (sce:YAL020C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1561836;18466297;18627462;24374639;25543256;25604895;27694803;7731988;8070652;8144453;8458570", "class_list": "", "function": "Together with KTI11; associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex (PubMed:18466297, PubMed:25543256). Association with the elongator complex is mediated via interaction with KTI11 (PubMed:18466297, PubMed:25543256). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:25543256). Together with KTI11; also required for diphthamide biosynthesis; diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:25543256). May participate in regulatory interactions between microtubules and the cell cycle (PubMed:8070652)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPJ8", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0002098 tRNA wobble uridine modification;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P31386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31787-1", "uniprot_id": "ACBP_YEAST", "mass": 10061.0, "length": 87, "protein_name": "Acyl-CoA-binding protein", "gene_name": "ACB1", "organism": "Yeast", "refseq_name": "long-chain fatty acid transporter ACB1", "refseq_ac": "NP_011551", "gene_names_uniprotkb": "ACB1; ACB", "gene_names_refseq": "ACB1", "protein_names_uniprotkb": "Acyl-CoA-binding protein; ACBP", "protein_names_refseq": "long-chain fatty acid transporter ACB1", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cardiovascular system disease (Disease Ontology:DOID:1287); morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (sce:YGR037C); (R-SCE-77289)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1454809;14562106;15690348;16273108;22106047;24374639;33481703;39528796;9169869;9290212;9434347", "class_list": "", "function": "Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. Enhances the in vitro activity of the ceramide synthase complex (PubMed:39528796)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUH4;Q45U46", "ec_number_list": "", "go_molecular_function": "GO:0036042 long-chain fatty acyl-CoA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P31787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32469-1", "uniprot_id": "DPH5_YEAST", "mass": 33847.0, "length": 300, "protein_name": "Diphthine methyl ester synthase", "gene_name": "DPH5", "organism": "Yeast", "refseq_name": "diphthine synthase", "refseq_ac": "NP_013273", "gene_names_uniprotkb": "DPH5; L9470.17", "gene_names_refseq": "DPH5", "protein_names_uniprotkb": "Diphthine methyl ester synthase; 2.1.1.314; Diphthamide biosynthesis methyltransferase", "protein_names_refseq": "diphthine synthase", "tax_id": 559292, "disease": "neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties (Disease Ontology:DOID:0070479)", "pathway": " (sce:YLR172C); (R-SCE-5358493)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "14562095;14562106;1508200;17322287;17330950;18407956;18627462;19684113;19779198;19795423;19823750;20702584;21126336;23749301;24374639;24739148;32597660;33481703;33491328;8373805;9169871", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYH6;Q6Q5L4", "ec_number_list": "3.6.5.-;2.1.1.314", "go_molecular_function": "GO:0004164 diphthine synthase activity;GO:0141133 diphthine methyl ester synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32469-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36164-1", "uniprot_id": "TVP38_YEAST", "mass": 38311.0, "length": 337, "protein_name": "Golgi apparatus membrane protein TVP38", "gene_name": "TVP38", "organism": "Yeast", "refseq_name": "Tvp38p", "refseq_ac": "NP_013014", "gene_names_uniprotkb": "TVP38; YKR408", "gene_names_refseq": "TVP38", "protein_names_uniprotkb": "Golgi apparatus membrane protein TVP38; TLG2-vesicle protein of 38 kDa", "protein_names_refseq": "Tvp38p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR088C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;16107716;16847258;17178117;17322287;18407956;19779198;24374639;30093494;33481703;33491328;8196765;8203164", "class_list": "", "function": "Golgi membrane protein involved in vesicular trafficking and spindle migration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0000022 mitotic spindle elongation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P36164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38166-1", "uniprot_id": "SFT2_YEAST", "mass": 24274.0, "length": 215, "protein_name": "Protein transport protein SFT2", "gene_name": "SFT2", "organism": "Yeast", "refseq_name": "Sft2p", "refseq_ac": "NP_009448", "gene_names_uniprotkb": "SFT2; YBL0812", "gene_names_refseq": "SFT2", "protein_names_uniprotkb": "Protein transport protein SFT2", "protein_names_refseq": "Sft2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL102W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10406798;14562106;16847258;17322287;18407956;22814378;23749301;24374639;33481703;33491328;7502586;7596416;7813418", "class_list": "", "function": "Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. Can be partially replaced by GOT1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPQ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0000138 Golgi trans cisterna", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53914-1", "uniprot_id": "NAT10_YEAST", "mass": 119348.0, "length": 1056, "protein_name": "RNA cytidine acetyltransferase", "gene_name": "KRE33", "organism": "Yeast", "refseq_name": "ribosome biosynthesis protein KRE33", "refseq_ac": "NP_014267", "gene_names_uniprotkb": "KRE33; N1216; N1858; NAT10; RRA1", "gene_names_refseq": "KRE33; RRA1", "protein_names_uniprotkb": "RNA cytidine acetyltransferase; 18S rRNA cytosine acetyltransferase; 2.3.1.-; Killer toxin-resistance protein 33; Ribosomal RNA cytidine acetyltransferase 1", "protein_names_refseq": "ribosome biosynthesis protein KRE33", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL132W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12150911;12663529;14562095;18407956;19779198;19795423;19823750;21126336;22814378;23749301;24374639;25086048;25653167;32597660;33481703;33491328;8619318;9169873", "class_list": "", "function": "RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1280 and 1773 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25086048, PubMed:25653167). Catalyzes the formation of ac4C at position 12 in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167)., [UniProtKB, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W150", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0051392 tRNA cytidine N4-acetyltransferase activity;GO:1990883 18S rRNA cytidine N-acetyltransferase activity;GO:0005524 ATP binding;GO:0030515 snoRNA binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0051391 tRNA acetylation;GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA;GO:0016556 mRNA modification;GO:0002101 tRNA wobble cytosine modification;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53914-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01519-1", "uniprot_id": "COX12_YEAST", "mass": 9788.0, "length": 83, "protein_name": "Cytochrome c oxidase subunit 12, mitochondrial", "gene_name": "COX12", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit VIb", "refseq_ac": "NP_013139", "gene_names_uniprotkb": "COX12", "gene_names_refseq": "COX12", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 12, mitochondrial; Cytochrome c oxidase polypeptide VIb", "protein_names_refseq": "cytochrome c oxidase subunit VIb", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 7 (Disease Ontology:DOID:0070494); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (sce:YLR038C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10764779;10775262;1331057;1331058;14562106;17322287;17761666;21126336;22814378;22984289;24374639;30598554;30598556;33481703;33491328;7851399;9169871", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY41;Q9URA6", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q01519-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03529-1", "uniprot_id": "SCS7_YEAST", "mass": 44881.0, "length": 384, "protein_name": "Ceramide very long chain fatty acid hydroxylase SCS7", "gene_name": "SCS7", "organism": "Yeast", "refseq_name": "fatty acid alpha-hydroxylase", "refseq_ac": "NP_013999", "gene_names_uniprotkb": "SCS7; FAH1; YM8156.14C", "gene_names_refseq": "FAH1; SCS7", "protein_names_uniprotkb": "Ceramide very long chain fatty acid hydroxylase SCS7; 1.14.18.6; 1.14.18.7; 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase SCS7; Ceramide VLCFA hydroxylase SCS7; Dihydroceramide fatty acyl 2-hydroxylase SCS7; Sphingolipid alpha-hydroxylase; Suppressor of calcium sensitivity 7", "protein_names_refseq": "fatty acid alpha-hydroxylase", "tax_id": 559292, "disease": "hereditary spastic paraplegia 35 (Disease Ontology:DOID:0110786)", "pathway": " (sce:YMR272C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10922463;12006573;14562095;14562106;16652392;16847258;17322287;19074599;21126336;23749301;24374639;26515067;26977056;33481703;33491328;9169872;9353282;9368039;9559540", "class_list": "", "function": "Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids (PubMed:16652392, PubMed:19074599, PubMed:26977056, PubMed:9353282, PubMed:9368039, PubMed:9559540). Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2 (PubMed:26977056, PubMed:9368039)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W098", "ec_number_list": "1.14.18.6;1.14.18.7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0020037 heme binding;GO:0080132 fatty acid 2-hydroxylase activity;GO:0102772 sphingolipid C4-monooxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0006673 inositol phosphoceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q03529-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04371-1", "uniprot_id": "ARMT1_YEAST", "mass": 54129.0, "length": 470, "protein_name": "Damage-control phosphatase YMR027W", "gene_name": "YM9711.17", "organism": "Yeast", "refseq_name": "putative methyltransferase", "refseq_ac": "NP_013740", "gene_names_uniprotkb": "YM9711.17", "gene_names_refseq": "", "protein_names_uniprotkb": "Damage-control phosphatase YMR027W; 3.1.3.-; Sugar phosphate phosphatase YMR027W", "protein_names_refseq": "putative methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR027W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11598186;14562106;18085829;23749301;24374639;27322068;33491328;9169872", "class_list": "", "function": "Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (PubMed:27322068). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (PubMed:27322068)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZK1", "ec_number_list": "3.1.3.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016791 phosphatase activity;GO:0097023 fructose 6-phosphate aldolase activity;GO:0103026 fructose-1-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04401-1", "uniprot_id": "SDHF3_YEAST", "mass": 15783.0, "length": 133, "protein_name": "Succinate dehydrogenase assembly factor 3, mitochondrial", "gene_name": "SDH7", "organism": "Yeast", "refseq_name": "Sdh7p", "refseq_ac": "NP_010799", "gene_names_uniprotkb": "SDH7; ACN9; D9719.16", "gene_names_refseq": "ACN9; SDH7", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 3, mitochondrial; Acetate non-utilizing protein 9; SDH assembly factor 3; SDHAF3", "protein_names_refseq": "Sdh7p", "tax_id": 559292, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537)", "pathway": " (sce:YDR511W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10103055;10328823;14562095;14562106;16823961;17322287;19837041;21126336;24374639;24954417;8878673;9169867", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDH2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. Acts together with SDHAF1 (SDH6)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTD2;Q02562", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006111 regulation of gluconeogenesis;GO:0034553 mitochondrial respiratory chain complex II assembly;GO:0015976 carbon utilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q04401-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04603-1", "uniprot_id": "DPB4_YEAST", "mass": 21997.0, "length": 196, "protein_name": "DNA polymerase epsilon subunit D", "gene_name": "DPB4", "organism": "Yeast", "refseq_name": "DNA polymerase epsilon noncatalytic subunit", "refseq_ac": "NP_010406", "gene_names_uniprotkb": "DPB4", "gene_names_refseq": "DPB4", "protein_names_uniprotkb": "DNA polymerase epsilon subunit D; DNA polymerase II subunit D", "protein_names_refseq": "DNA polymerase epsilon noncatalytic subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR121W); (R-SCE-6782135); (R-SCE-68952); (R-SCE-68962)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "11024162;11081629;11238944;11533234;12124389;12571237;14562106;14673157;15024052;17322287;17563356;18407956;20190278;21126336;21177495;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. Also functions as a component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSA7", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0008623 CHRAC", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q04603-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04781-1", "uniprot_id": "LTN1_YEAST", "mass": 180186.0, "length": 1562, "protein_name": "E3 ubiquitin-protein ligase listerin", "gene_name": "RKR1", "organism": "Yeast", "refseq_name": "ubiquitin-protein ligase RKR1", "refseq_ac": "NP_013975", "gene_names_uniprotkb": "RKR1; LTN1; YM9408.09C; YM9920.01C", "gene_names_refseq": "LTN1; RKR1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase listerin; 2.3.2.27; RING domain mutant killed by rtf1 deletion protein 1; RING-type E3 ubiquitin transferase listerin", "protein_names_refseq": "ubiquitin-protein ligase RKR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR247C); (R-SCE-983168); (R-SCE-9954709)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "14562106;17283062;19684113;19795423;19823750;20835226;23178123;23479637;23749301;23825054;24261871;24374639;25349383;25554787;26055716;26934223;27129255;27385828;31133701;33481703;33491328;36804914;9169872", "class_list": "", "function": "E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123, PubMed:26055716, PubMed:26934223, PubMed:27385828, PubMed:31133701, PubMed:36804914). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons (PubMed:20835226, PubMed:23825054, PubMed:24261871, PubMed:26934223, PubMed:31133701). Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:26055716, PubMed:27129255). May indirectly play a role in chromatin function and transcription (PubMed:17283062)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W074;Q04029", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;3.6.4.6;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:1990112 RQC complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0031509 subtelomeric heterochromatin formation;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q04781-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05871-1", "uniprot_id": "ECI1_YEAST", "mass": 31698.0, "length": 280, "protein_name": "3,2-trans-enoyl-CoA isomerase", "gene_name": "ECI1", "organism": "Yeast", "refseq_name": "dodecenoyl-CoA isomerase", "refseq_ac": "NP_013386", "gene_names_uniprotkb": "ECI1", "gene_names_refseq": "ECI1", "protein_names_uniprotkb": "3,2-trans-enoyl-CoA isomerase; 5.3.3.8; D3,D2-enoyl-CoA isomerase; Delta(3),Delta(2)-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase", "protein_names_refseq": "dodecenoyl-CoA isomerase", "tax_id": 559292, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YLR284C); (R-SCE-390247); (R-SCE-9033241)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10381339;10944342;11302517;11399063;14741345;24374639;26527136;9169871;9837886", "class_list": "", "function": "Essential for the beta oxidation of unsaturated fatty acids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYS8", "ec_number_list": "1.11.1.6;1.6.2.4;1.1.1.42;1.3.1.124;2.3.1.7;4.1.2.63;3.1.2.2;2.3.2.27;5.3.3.8;3.4.24.-;3.6.1.-;3.6.1.56;3.6.1.77", "go_molecular_function": "GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q05871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06287-1", "uniprot_id": "NEP1_YEAST", "mass": 27895.0, "length": 252, "protein_name": "Ribosomal RNA small subunit methyltransferase NEP1", "gene_name": "EMG1", "organism": "Yeast", "refseq_name": "18S rRNA pseudouridine methyltransferase", "refseq_ac": "NP_013287", "gene_names_uniprotkb": "EMG1; L9470.5; NEP1", "gene_names_refseq": "EMG1; NEP1", "protein_names_uniprotkb": "Ribosomal RNA small subunit methyltransferase NEP1; 18S rRNA (pseudouridine(1189)-N1)-methyltransferase; 18S rRNA Psi1189 methyltransferase; 2.1.1.260; Essential for mitotic growth protein 1; Nucleolar essential protein 1", "protein_names_refseq": "18S rRNA pseudouridine methyltransferase", "tax_id": 559292, "disease": "Bowen-Conradi syndrome (Disease Ontology:DOID:0050684)", "pathway": " (sce:YLR186W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11694595;11935223;15590835;17322287;18063569;18208838;19795423;19823750;20972225;21087996;24374639;33491328;9169871", "class_list": "", "function": "S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1189 (Psi1189) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. N1-methylation is independent on acp-modification at the N3-position of U1191. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 (RPS19A/RPS19B) during the formation of pre-ribosomes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYI9;E9P8U2", "ec_number_list": "2.1.1.-;2.7.11.1;3.6.4.13;2.1.1.260;3.6.5.-;3.1.13.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0019843 rRNA binding;GO:0070037 rRNA (pseudouridine) methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0034399 nuclear periphery", "go_biological_process": "GO:0031167 rRNA methylation;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q06287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06407-1", "uniprot_id": "RGA2_YEAST", "mass": 113291.0, "length": 1009, "protein_name": "Rho-type GTPase-activating protein 2", "gene_name": "RGA2", "organism": "Yeast", "refseq_name": "GTPase-activating protein RGA2", "refseq_ac": "NP_010667", "gene_names_uniprotkb": "RGA2; D9481.4", "gene_names_refseq": "RGA2", "protein_names_uniprotkb": "Rho-type GTPase-activating protein 2", "protein_names_refseq": "GTPase-activating protein RGA2", "tax_id": 559292, "disease": "Duane retraction syndrome (Disease Ontology:DOID:12557)", "pathway": " (sce:YDR379W); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013148); (R-SCE-9013149); (R-SCE-9013423); (R-SCE-9013424); (R-SCE-9035034)", "pathway_count": 8, "publication_count": 24, "publication_id_list": "12455995;14517318;14562106;17330950;17563356;17853895;17981141;18166650;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9169867", "class_list": "", "function": "GTPase-activating protein (GAP) for CDC42, accelerating hydrolysis of GTP to GDP by CDC42 thereby inactivating CDC42 (PubMed:12455995, PubMed:17981141). Involved in the formation of the mature septin ring at the mother-bud neck (PubMed:14517318)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 59, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VT11", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030427 site of polarized growth;GO:0032153 cell division site", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0030010 establishment of cell polarity;GO:0031106 septin ring organization", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q06407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06510-1", "uniprot_id": "TAZ_YEAST", "mass": 44188.0, "length": 381, "protein_name": "Tafazzin", "gene_name": "TAZ1", "organism": "Yeast", "refseq_name": "lysophosphatidylcholine acyltransferase", "refseq_ac": "NP_015466", "gene_names_uniprotkb": "TAZ1", "gene_names_refseq": "TAZ1", "protein_names_uniprotkb": "Tafazzin; 2.3.1.-; Taz", "protein_names_refseq": "lysophosphatidylcholine acyltransferase", "tax_id": 559292, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); visceral heterotaxy (Disease Ontology:DOID:0050545); cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (sce:YPR140W); (R-SCE-1268020); (R-SCE-1482798)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "14562095;14562106;14576278;14651618;15588229;16135531;16880272;17322287;24078306;24374639;28202545;29091407;9169875", "class_list": "", "function": "Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (PubMed:14651618, PubMed:28202545, PubMed:29091407). Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (PubMed:16135531). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor (By similarity). CoA-independent, it can reshuffle molecular species within a single phospholipid class (PubMed:15588229). Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes. Essential for the final stage of spermatogenesis, spermatid individualization (By similarity). Required for the initiation of mitophagy (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4D8;Q6B2J1", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport;GO:0035965 cardiolipin acyl-chain remodeling;GO:0008654 phospholipid biosynthetic process;GO:0032048 cardiolipin metabolic process;GO:0007007 inner mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q06510-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08096-1", "uniprot_id": "RCL1_YEAST", "mass": 40171.0, "length": 367, "protein_name": "rRNA processing protein RCL1", "gene_name": "RCL1", "organism": "Yeast", "refseq_name": "rRNA-processing endoribonuclease", "refseq_ac": "NP_014633", "gene_names_uniprotkb": "RCL1; RTC1", "gene_names_refseq": "RCL1", "protein_names_uniprotkb": "rRNA processing protein RCL1; RNA 3'-terminal phosphate cyclase-like protein 1", "protein_names_refseq": "rRNA-processing endoribonuclease", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL010W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10790377;11565748;14562106;16307926;16376378;22814378;24374639;25064857;27419870;27980088;28244370;28945246;32943521;32943522;33326748;33491328;35650250;9169874", "class_list": "", "function": "Does not have cyclase activity (PubMed:10790377). Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (PubMed:10790377, PubMed:11565748, PubMed:16307926, PubMed:16376378, PubMed:25064857). RCL1 activates BMS1 by promoting GDP/GTP exchange (PubMed:16307926, PubMed:16376378)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W257", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:2000232 regulation of rRNA processing;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q08096-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08965-1", "uniprot_id": "BMS1_YEAST", "mass": 135571.0, "length": 1183, "protein_name": "Ribosome biogenesis protein BMS1", "gene_name": "BMS1", "organism": "Yeast", "refseq_name": "GTPase BMS1", "refseq_ac": "NP_015107", "gene_names_uniprotkb": "BMS1", "gene_names_refseq": "BMS1", "protein_names_uniprotkb": "Ribosome biogenesis protein BMS1; 3.6.5.-", "protein_names_refseq": "GTPase BMS1", "tax_id": 559292, "disease": "nonsyndromic aplasia cutis congenita (Disease Ontology:DOID:0080661)", "pathway": " (sce:YPL217C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "11565748;11565749;16307926;16376378;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21177495;23749301;24374639;25064857;27419870;27980088;28244370;28945246;30516470;32943521;32943522;33326748;33481703;33491328;35650250;36263816;9169875", "class_list": "", "function": "GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2 (PubMed:11565748, PubMed:11565749, PubMed:16307926, PubMed:16376378). Controls access of pre-ribosomal RNA intermediates to RCL1 during ribosome biogenesis by binding of RCL1 in a GTP-dependent manner and, via its affinity to U3 snoRNA, delivering it to pre-ribosomes (PubMed:16307926, PubMed:16376378). GTP-binding and/or GTP hydrolysis may induce conformational rearrangements within the BMS1-RCL1 complex allowing the interaction of RCL1 with its RNA substrate (PubMed:25064857). Required for RCL1 import into the nucleus (PubMed:25064857)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3F3", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;2.1.1.-;2.7.11.1;3.6.5.4;3.6.5.5;3.6.4.13;2.1.1.260;3.1.13.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:2000232 regulation of rRNA processing;GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q08965-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12052-1", "uniprot_id": "TGS1_YEAST", "mass": 36527.0, "length": 315, "protein_name": "Trimethylguanosine synthase", "gene_name": "TGS1", "organism": "Yeast", "refseq_name": "RNA methyltransferase", "refseq_ac": "NP_015168", "gene_names_uniprotkb": "TGS1; P2573", "gene_names_refseq": "TGS1", "protein_names_uniprotkb": "Trimethylguanosine synthase; 2.1.1.-; Cap-specific guanine-N(2) methyltransferase; snRNA/snoRNA cap hypermethylase", "protein_names_refseq": "RNA methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL157W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11983179;12907733;14562095;15340060;17563356;18775984;18840651;19684113;19779198;20702584;21177495;24374639;33481703;33491328;8948103;9169875", "class_list": "", "function": "Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3L1", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0071164 RNA cap trimethylguanosine synthase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0017126 nucleologenesis;GO:0008033 tRNA processing;GO:0032210 regulation of telomere maintenance via telomerase;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12052-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12093-1", "uniprot_id": "MTU1_YEAST", "mass": 47049.0, "length": 417, "protein_name": "Mitochondrial tRNA-specific 2-thiouridylase 1", "gene_name": "SLM3", "organism": "Yeast", "refseq_name": "tRNA-5-taurinomethyluridine 2-sulfurtransferase", "refseq_ac": "NP_010251", "gene_names_uniprotkb": "SLM3; D2761; MTO2; MTU1", "gene_names_refseq": "MTO2; MTU1; SLM3", "protein_names_uniprotkb": "Mitochondrial tRNA-specific 2-thiouridylase 1; 2.8.1.13; Mitochondrial translation optimization protein 2; Synthetic lethal with MSS4 3", "protein_names_refseq": "tRNA-5-taurinomethyluridine 2-sulfurtransferase", "tax_id": 559292, "disease": "infantile liver failure syndrome (Disease Ontology:DOID:0080716); transient infantile liver failure (Disease Ontology:DOID:0080778); aminoglycoside-induced deafness (Disease Ontology:DOID:0111734); inner ear disease (Disease Ontology:DOID:2952); MERRF syndrome (Disease Ontology:DOID:310); liver disease (Disease Ontology:DOID:409)", "pathway": " (sce:YDL033C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;15509579;15944150;17706197;19684113;24374639;9169867", "class_list": "", "function": "Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRW0;Q6IUF4", "ec_number_list": "2.8.1.13", "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0103016 tRNA-uridine 2-sulfurtransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0006400 tRNA modification;GO:1990799 mitochondrial tRNA wobble position uridine thiolation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q12093-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12150-1", "uniprot_id": "CSF1_YEAST", "mass": 338258.0, "length": 2958, "protein_name": "Protein CSF1", "gene_name": "CSF1", "organism": "Yeast", "refseq_name": "Csf1p", "refseq_ac": "NP_013188", "gene_names_uniprotkb": "CSF1; TWEEK", "gene_names_refseq": "CSF1", "protein_names_uniprotkb": "Protein CSF1; BLTP1; Bridge-like lipid transfer protein family member 1; Cold sensitive for fermentation protein 1", "protein_names_refseq": "Csf1p", "tax_id": 559292, "disease": "Alkuraya-Kucinskas syndrome (Disease Ontology:DOID:0111555)", "pathway": " (sce:YLR087C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10781556;19779198;24374639;33491328;35015055;9169871", "class_list": "", "function": "Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (PubMed:35015055). Required for the glucose and other nutrients uptake at low temperature (PubMed:10781556)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 23, "predicted_n_glycosites": 23, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "D6VY87", "ec_number_list": "", "go_molecular_function": "GO:1904121 phosphatidylethanolamine transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0055091 phospholipid homeostasis;GO:0051604 protein maturation;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12150-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12196-1", "uniprot_id": "RIO1_YEAST", "mass": 56122.0, "length": 484, "protein_name": "Serine/threonine-protein kinase RIO1", "gene_name": "RIO1", "organism": "Yeast", "refseq_name": "protein kinase RIO1", "refseq_ac": "NP_014762", "gene_names_uniprotkb": "RIO1; O3266; RRP10; YOR3266C", "gene_names_refseq": "RIO1; RRP10", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO1; 2.7.11.1; 3.6.1.-; Ribosomal RNA-processing protein 10", "protein_names_refseq": "protein kinase RIO1", "tax_id": 559292, "disease": "colon cancer (Disease Ontology:DOID:219)", "pathway": " (sce:YOR119C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11483523;11972772;12135737;12612080;17725716;18407956;23749301;24374639;24948609;33481703;33491328;34965436;8904341;9169874;9200815", "class_list": "", "function": "Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA. Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit. The association with the very late 40S subunit intermediate seems to follow RIO2 association with precursors of the 40S subunit and may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. Has a role in the cell cycle where it is required for entrance into S-phase and in the control of the onset of anaphase. Appears to also be involved in the maintenance of chromosome stability and correct mitotic segregation., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 35, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2H8;Q00602", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;3.6.4.13;2.7.12.2;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;2.7.12.1;2.7.11.24;3.6.4.-;5.6.1.4;2.7.11.17;2.7.11.23;2.7.11.25;3.6.4.12;2.7.11.13;2.1.1.309;3.6.4.6;5.6.2.5;3.1.26.-;2.7.11.21;2.7.1.67;3.6.1.-;2.3.2.27;3.1.26.5;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;7.2.2.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000776 kinetochore", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0007096 regulation of exit from mitosis;GO:0016479 negative regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12328-1", "uniprot_id": "TIM22_YEAST", "mass": 21864.0, "length": 207, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM22", "gene_name": "TIM22", "organism": "Yeast", "refseq_name": "translocation channel protein TIM22", "refseq_ac": "NP_010064", "gene_names_uniprotkb": "TIM22; D0884", "gene_names_refseq": "TIM22", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM22", "protein_names_refseq": "translocation channel protein TIM22", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 43 (Disease Ontology:DOID:0112116); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (sce:YDL217C); (R-SCE-1268020)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10397776;10648604;11864609;12637749;17322287;24374639;27265872;39753782;8955274;9046097;9169867;9430585;9495346", "class_list": "", "function": "Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins, such as mitochondrial carrier family members, into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps. Mediates the insertion of precursor proteins in a 3 step process. After the precursor is tethered to the translocase without losing energy from the Delta(psi), 2 energy-requiring steps are needed. First, Delta(psi) acts on the precursor protein and promotes its docking in the translocase complex. Then, Delta(psi) and an internal signal peptide together induce rapid gating transitions in one pore and closing of the other pore and drive membrane insertion to completion., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRD7", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12328-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12383-1", "uniprot_id": "TRM13_YEAST", "mass": 54095.0, "length": 476, "protein_name": "tRNA:m(4)X modification enzyme TRM13", "gene_name": "TRM13", "organism": "Yeast", "refseq_name": "tRNA:m4X modification enzyme", "refseq_ac": "NP_014516", "gene_names_uniprotkb": "TRM13", "gene_names_refseq": "TRM13", "protein_names_uniprotkb": "tRNA:m(4)X modification enzyme TRM13; 2.1.1.225; tRNA methylase 13", "protein_names_refseq": "tRNA:m4X modification enzyme", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL125W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;17242307;18407956;22814378;24374639;32053677;32597660;33481703;33491328;8896265;9169874", "class_list": "", "function": "tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1U3", "ec_number_list": "2.1.1.225", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0106050 tRNA 2'-O-methyltransferase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q12383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E793-1", "uniprot_id": "BOL1_YEAST", "mass": 12537.0, "length": 110, "protein_name": "BolA-like protein 1", "gene_name": "BOL1", "organism": "Yeast", "refseq_name": "Bol1p", "refseq_ac": "NP_075206", "gene_names_uniprotkb": "BOL1", "gene_names_refseq": "BOL1", "protein_names_uniprotkb": "BolA-like protein 1", "protein_names_refseq": "Bol1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL044W-A)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24374639;27532772;27532773;33491328;7731988", "class_list": "", "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH) (PubMed:27532772). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532772). Probably acts together with the monothiol glutaredoxin GRX5, earlier than BOL3 and NFU1 in the [4Fe-4S] cluster insertion process (PubMed:27532773). Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (PubMed:27532772)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3E793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38242-1", "uniprot_id": "ALG14_YEAST", "mass": 27035.0, "length": 237, "protein_name": "UDP-N-acetylglucosamine transferase subunit ALG14", "gene_name": "ALG14", "organism": "Yeast", "refseq_name": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14", "refseq_ac": "NP_009626", "gene_names_uniprotkb": "ALG14; YBR0711", "gene_names_refseq": "ALG14", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transferase subunit ALG14; Asparagine-linked glycosylation protein 14", "protein_names_refseq": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14", "tax_id": 559292, "disease": "congenital myasthenic syndrome 15 (Disease Ontology:DOID:0110658)", "pathway": " (sce:YBR070C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;15282802;15615718;16100110;17563356;17686769;24374639;24440502;7813418;7985423", "class_list": "", "function": "Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ69", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005811 lipid droplet;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38332-1", "uniprot_id": "DPH7_YEAST", "mass": 43308.0, "length": 387, "protein_name": "Diphthine methyltransferase", "gene_name": "RRT2", "organism": "Yeast", "refseq_name": "diphthamide synthase", "refseq_ac": "NP_009805", "gene_names_uniprotkb": "RRT2; DPH7; ERE1; YBR1634", "gene_names_refseq": "DPH7; ERE1; RRT2", "protein_names_uniprotkb": "Diphthine methyltransferase; 3.1.1.97; Diphthamide biosynthesis protein 7; Endosomal recycling protein 1; Regulator of rDNA transcription protein 2", "protein_names_refseq": "diphthamide synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR246W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;17322287;19270272;19965467;21880895;22188241;23468660;24374639;24739148;33491328;7813418", "class_list": "", "function": "Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EFT1 and EFT2). Also plays a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Identified in a screen for mutants with decreased levels of rDNA transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP2", "ec_number_list": "3.6.5.-;3.1.1.97", "go_molecular_function": "GO:0061685 diphthine methylesterase activity;GO:0051723 protein methylesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0032456 endocytic recycling;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38332-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38345-1", "uniprot_id": "SDHF4_YEAST", "mass": 15504.0, "length": 138, "protein_name": "Succinate dehydrogenase assembly factor 4, mitochondrial", "gene_name": "SDH8", "organism": "Yeast", "refseq_name": "Sdh8p", "refseq_ac": "NP_009828", "gene_names_uniprotkb": "SDH8; FMP21; YBR1737", "gene_names_refseq": "FMP21; SDH8", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 4, mitochondrial; Found in mitochondrial proteome protein 21; SDH assembly factor 4; SDHAF4", "protein_names_refseq": "Sdh8p", "tax_id": 559292, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (sce:YBR269C); (R-SCE-9854311)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12748633;14562095;14576278;18407956;21126336;21177495;23749301;24374639;24954416;33481703;33491328;7813418", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SDH1 in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDH2 into the SDH catalytic dimer., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR5", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034614 cellular response to reactive oxygen species;GO:1904231 positive regulation of succinate dehydrogenase activity;GO:0034553 mitochondrial respiratory chain complex II assembly;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38345-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38523-1", "uniprot_id": "GRPE_YEAST", "mass": 26066.0, "length": 228, "protein_name": "GrpE protein homolog, mitochondrial", "gene_name": "MGE1", "organism": "Yeast", "refseq_name": "mitochondrial nucleotide exchange factor MGE1", "refseq_ac": "NP_014875", "gene_names_uniprotkb": "MGE1; GRPE1; GRPE; O5099; YGE1", "gene_names_refseq": "MGE1; YGE1", "protein_names_uniprotkb": "GrpE protein homolog, mitochondrial", "protein_names_refseq": "mitochondrial nucleotide exchange factor MGE1", "tax_id": 559292, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (sce:YOR232W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11273703;16107694;24374639;33491328;7628446;8022808;8112465;8168496;8972580;9169874", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins and the association of SSC1 with TIM44., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2T6", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042026 protein refolding;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38523-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38857-1", "uniprot_id": "MPC2_YEAST", "mass": 14555.0, "length": 129, "protein_name": "Mitochondrial pyruvate carrier 2", "gene_name": "MPC2", "organism": "Yeast", "refseq_name": "mitochondrial pyruvate carrier", "refseq_ac": "NP_012032", "gene_names_uniprotkb": "MPC2", "gene_names_refseq": "MPC2", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 2; MPC2", "protein_names_refseq": "mitochondrial pyruvate carrier", "tax_id": 559292, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (sce:YHR162W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;17322287;22628554;22628558;24374639;25672363;30979775;8091229", "class_list": "", "function": "Together with MCP1, mediates the uptake of pyruvate into mitochondria under fermentative conditions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLB1", "ec_number_list": "", "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:7770001 mitochondrial pyruvate carrier complex", "go_biological_process": "GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38857-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38862-1", "uniprot_id": "ATG7_YEAST", "mass": 71428.0, "length": 630, "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "organism": "Yeast", "refseq_name": "Atg7p", "refseq_ac": "NP_012041", "gene_names_uniprotkb": "ATG7; APG7; CVT2", "gene_names_refseq": "APG11; APG7; ATG7; CVT2", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; Cytoplasm to vacuole targeting protein 2", "protein_names_refseq": "Atg7p", "tax_id": 559292, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); cardiac arrest (Disease Ontology:DOID:0060319); autosomal recessive spinocerebellar ataxia 31 (Disease Ontology:DOID:0070412); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertension (Disease Ontology:DOID:10763); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); high grade glioma (Disease Ontology:DOID:3070); myocardial infarction (Disease Ontology:DOID:5844); paraplegia (Disease Ontology:DOID:607); nervous system disease (Disease Ontology:DOID:863); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (sce:YHR171W); (R-SCE-1632852); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 34, "publication_id_list": "10233148;10233150;11100732;11139573;11149920;12965207;14536056;15277523;16027116;16874032;17227760;17632063;17890363;18497569;18544538;18701704;18725539;19061865;19302372;21193819;22055190;22055191;22056771;22768199;22785534;23142976;23660403;24374639;29295865;33491328;7593182;8091229;8224160;9759731", "class_list": "", "function": "E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLC0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0019778 Atg12 activating enzyme activity;GO:0019779 Atg8 activating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0000422 autophagy of mitochondrion;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P38862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38874-1", "uniprot_id": "ELP5_YEAST", "mass": 35220.0, "length": 309, "protein_name": "Elongator complex protein 5", "gene_name": "IKI1", "organism": "Yeast", "refseq_name": "Elongator subunit IKI1", "refseq_ac": "NP_012057", "gene_names_uniprotkb": "IKI1; ELP5; HAP2; TOT5", "gene_names_refseq": "ELP5; HAP2; IKI1; TOT5", "protein_names_uniprotkb": "Elongator complex protein 5; Gamma-toxin target 5; HAT-associated protein 2; Protein IKI1", "protein_names_refseq": "Elongator subunit IKI1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR187W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10024884;11296232;11390369;11435442;11689709;11904415;13680368;14562095;14562106;15769872;15780940;18627462;22343726;22556426;24374639;25569479;27872205;27974378;29332244;31309145;8091229;9145530", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38874-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38991-1", "uniprot_id": "AURK_YEAST", "mass": 42946.0, "length": 367, "protein_name": "Aurora kinase", "gene_name": "IPL1", "organism": "Yeast", "refseq_name": "aurora kinase", "refseq_ac": "NP_015115", "gene_names_uniprotkb": "IPL1", "gene_names_refseq": "IPL1; PAC15", "protein_names_uniprotkb": "Aurora kinase; 2.7.11.1; Increase-in-ploidy protein 1; Spindle assembly checkpoint kinase", "protein_names_refseq": "aurora kinase", "tax_id": 559292, "disease": "spermatogenic failure 5 (Disease Ontology:DOID:0070183); urinary bladder cancer (Disease Ontology:DOID:11054); brain cancer (Disease Ontology:DOID:1319); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); invasive ductal carcinoma (Disease Ontology:DOID:3008); uterine cancer (Disease Ontology:DOID:363); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YPL209C); (R-SCE-8854050)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10385519;10975519;11724818;11853667;12408861;14562106;17287358;17322287;17563356;18079178;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22561345;23454383;23749301;24374639;24558497;32597660;33481703;33491328;8007975;9169875", "class_list": "", "function": "Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis (PubMed:11853667, PubMed:12408861). Has a role in error-correction of aberrent kinetochore-microtubule attachments to ensure that sister kinetochores become bioriented and connect to opposite poles by promoting spindle assembly checkpoint signaling (PubMed:11724818, PubMed:11853667, PubMed:12408861). Acts in opposition to the phosphatase PP1 (PubMed:10975519). Not required for kinetochore detachment from microtubules during replication of centromeric DNA (PubMed:18079178). Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (PubMed:10975519). Phosphorylates CNN1, which contributes to the enrichment of CNN1 on anaphase kinetochores (PubMed:22561345). Phosphorylates RGD1 (PubMed:23454383)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3G1", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0044774 mitotic DNA integrity checkpoint signaling;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0018107 peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P38991-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39083-1", "uniprot_id": "RGA1_YEAST", "mass": 112832.0, "length": 1007, "protein_name": "Rho-type GTPase-activating protein 1", "gene_name": "RGA1", "organism": "Yeast", "refseq_name": "GTPase-activating protein RGA1", "refseq_ac": "NP_014770", "gene_names_uniprotkb": "RGA1; DBM1; O3290; THE1; YOR3290W", "gene_names_refseq": "DBM1; RGA1; THE1", "protein_names_uniprotkb": "Rho-type GTPase-activating protein 1", "protein_names_refseq": "GTPase-activating protein RGA1", "tax_id": 559292, "disease": "Duane retraction syndrome (Disease Ontology:DOID:12557)", "pathway": " (sce:YOR127W); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013148); (R-SCE-9013149); (R-SCE-9013423); (R-SCE-9013424); (R-SCE-9035034)", "pathway_count": 8, "publication_count": 23, "publication_id_list": "1454852;14562106;15665377;17330950;18407956;19684113;19779198;19795423;19823750;20489023;23749301;24374639;25860339;32597660;33229814;33481703;33491328;34680163;7498791;8657111;8904341;9169874;9200815", "class_list": "", "function": "GTPase-activating protein (GAP) for CDC42 and/or RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G protein and the MAP kinase module. Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2. Involved in the control of polarized cell growth and proper bud site selection., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 51, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W2I5;P39934", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030427 site of polarized growth", "go_biological_process": "GO:0007015 actin filament organization;GO:0007264 small GTPase-mediated signal transduction;GO:0030010 establishment of cell polarity;GO:0031106 septin ring organization;GO:0007119 budding cell isotropic bud growth", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P39083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39730-1", "uniprot_id": "IF2P_YEAST", "mass": 112268.0, "length": 1002, "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "FUN12", "organism": "Yeast", "refseq_name": "translation initiation factor eIF5B", "refseq_ac": "NP_009365", "gene_names_uniprotkb": "FUN12", "gene_names_refseq": "FUN12; yIF2", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5B; 3.6.5.3; Translation initiation factor IF-2; eIF-5B", "protein_names_refseq": "translation initiation factor eIF5B", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL035W); (R-SCE-72706)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "12008673;12471154;12507428;14562106;17330950;17563356;17913624;18976658;19029250;19779198;20702584;21126336;21177495;22751017;23749301;24200810;24374639;24686316;25478828;32597660;33481703;33491328;7731988;8076820;9624054", "class_list": "", "function": "Plays a role in translation initiation (PubMed:9624054). Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:12008673, PubMed:12471154, PubMed:12507428). GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome (PubMed:25478828). The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes (PubMed:12507428, PubMed:18976658, PubMed:19029250). Stimulates 20S pre-rRNA cleavage to mature 18S rRNA by PIN-domain endonuclease NOB1 (PubMed:22751017)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI2", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P39730-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39976-1", "uniprot_id": "DLD3_YEAST", "mass": 55225.0, "length": 496, "protein_name": "D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3", "gene_name": "DLD3", "organism": "Yeast", "refseq_name": "D-lactate dehydrogenase", "refseq_ac": "NP_010843", "gene_names_uniprotkb": "DLD3", "gene_names_refseq": "DLD3", "protein_names_uniprotkb": "D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; 1.1.2.4; 1.1.99.40; D-2HG--pyruvate transhydrogenase DLD3; D-LCR; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase", "protein_names_refseq": "D-lactate dehydrogenase", "tax_id": 559292, "disease": "D-2-hydroxyglutaric aciduria 1 (Disease Ontology:DOID:0111351); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YEL071W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10509019;12872131;14562106;18407956;19795423;19823750;22814378;24374639;26774271;33481703;33491328;9169868", "class_list": "", "function": "Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate. Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLI0", "ec_number_list": "1.1.2.4;1.1.99.40", "go_molecular_function": "GO:0071949 FAD binding;GO:0004458 D-lactate dehydrogenase (cytochrome) activity;GO:0099615 (R)-2-hydroxyglutarate-pyruvate transhydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0019249 lactate biosynthetic process;GO:0030447 filamentous growth", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P39976-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39986-1", "uniprot_id": "SPF1_YEAST", "mass": 135269.0, "length": 1215, "protein_name": "Endoplasmic reticulum transmembrane helix translocase", "gene_name": "SPF1", "organism": "Yeast", "refseq_name": "ion-transporting P-type ATPase SPF1", "refseq_ac": "NP_010883", "gene_names_uniprotkb": "SPF1; COD1", "gene_names_refseq": "COD1; PER9; PIO1; SPF1", "protein_names_uniprotkb": "Endoplasmic reticulum transmembrane helix translocase; 7.4.2.-; Complexed with DOR1 protein 1; Endoplasmic reticulum P5A-ATPase; Sensitivity to the P.farinosa killer toxin protein 1", "protein_names_refseq": "ion-transporting P-type ATPase SPF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL031W); (R-SCE-936837)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10361284;12058017;14562106;16847258;17563356;18407956;22745129;22814378;22918956;23749301;24374639;24392018;30785834;32353073;32597660;32973005;33481703;33491328;9169868", "class_list": "", "function": "Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:22918956, PubMed:32973005). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLL8", "ec_number_list": "7.4.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0043335 protein unfolding;GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0030026 intracellular manganese ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P39986-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40032-1", "uniprot_id": "TPA1_YEAST", "mass": 74041.0, "length": 644, "protein_name": "Prolyl 3,4-dihydroxylase TPA1", "gene_name": "TPA1", "organism": "Yeast", "refseq_name": "oxidative DNA demethylase", "refseq_ac": "NP_010969", "gene_names_uniprotkb": "TPA1", "gene_names_refseq": "TPA1", "protein_names_uniprotkb": "Prolyl 3,4-dihydroxylase TPA1; 1.14.11.-; Termination and polyadenylation protein 1; uS12 prolyl 3,4-dihydroxylase", "protein_names_refseq": "oxidative DNA demethylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER049W); (R-SCE-9629569)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "14562095;14562106;16809762;18407956;19779198;20040577;20489023;20630870;23749301;24374639;24550462;25728928;33481703;33491328;9169868", "class_list": "", "function": "Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-64' of small ribosomal subunit uS12 (RPS23A and RPS23B), thereby regulating protein translation termination efficiency. Part of a messenger ribonucleoprotein (mRNP) complex at the 3'-UTR of mRNAs. It associates specifically with components of the translation termination complex and is involved in both translation termination and in regulation of normal mRNA decay through translation termination-coupled poly(A) shortening., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLV1", "ec_number_list": "1.14.11.-", "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0031543 peptidyl-proline dioxygenase activity;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0006415 translational termination;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0006450 regulation of translational fidelity;GO:0018188 peptidyl-proline di-hydroxylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40032-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40034-1", "uniprot_id": "JHD1_YEAST", "mass": 56530.0, "length": 492, "protein_name": "JmjC domain-containing histone demethylation protein 1", "gene_name": "JHD1", "organism": "Yeast", "refseq_name": "[Histone H3]-lysine-36 demethylase", "refseq_ac": "NP_010971", "gene_names_uniprotkb": "JHD1", "gene_names_refseq": "JHD1; KDM2", "protein_names_uniprotkb": "JmjC domain-containing histone demethylation protein 1; 1.14.11.27; Jumonji/ARID domain-containing protein 1; ScJHDM1; [Histone-H3]-lysine-36 demethylase 1", "protein_names_refseq": "[Histone H3]-lysine-36 demethylase", "tax_id": 559292, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Siderius type (Disease Ontology:DOID:0060812); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); prostate cancer (Disease Ontology:DOID:10283); melanoma (Disease Ontology:DOID:1909); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YER051W); (R-SCE-2299718); (R-SCE-3214842); (R-SCE-983168)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14562106;16362057;24374639;33334889;35183557;9169868", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Does not demethylate H3 'Lys-4' nor 'Lys-79'., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLV3", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0032452 histone demethylase activity;GO:0140680 histone H3K36me/H3K36me2 demethylase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40344-1", "uniprot_id": "ATG3_YEAST", "mass": 35887.0, "length": 310, "protein_name": "Autophagy-related protein 3", "gene_name": "ATG3", "organism": "Yeast", "refseq_name": "Atg3p", "refseq_ac": "NP_014404", "gene_names_uniprotkb": "ATG3; APG3; AUT1; N2040", "gene_names_refseq": "APG3; ATG3; AUT1", "protein_names_uniprotkb": "Autophagy-related protein 3; Autophagy-related E2-like conjugation enzyme ATG3", "protein_names_refseq": "Atg3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR007C); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 39, "publication_id_list": "11058089;11100732;11139573;11149920;11689437;12965207;14536056;14562095;14562106;15277523;17012800;17227760;17632063;17890363;17986448;18544538;18701704;18725539;19235764;19285500;19303850;20615880;21193819;22055190;22055191;22056771;22240591;22539722;22768199;23142976;23503366;24374639;30510114;33491328;7900425;8050581;8224160;9023185;9169873", "class_list": "", "function": "E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1I2", "ec_number_list": "", "go_molecular_function": "GO:0019776 Atg8-family ligase activity;GO:0141046 Atg8-family conjugating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000407 phagophore assembly site;GO:0061908 phagophore", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006612 protein targeting to membrane;GO:0000422 autophagy of mitochondrion;GO:0006501 C-terminal protein lipidation;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P40344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40492-1", "uniprot_id": "FYV10_YEAST", "mass": 59894.0, "length": 516, "protein_name": "GID complex subunit 9", "gene_name": "FYV10", "organism": "Yeast", "refseq_name": "glucose-induced degradation complex subunit FYV10", "refseq_ac": "NP_012169", "gene_names_uniprotkb": "FYV10; GID9", "gene_names_refseq": "FYV10; GID9", "protein_names_uniprotkb": "GID complex subunit 9; 2.3.2.27; Function required for yeast viability protein 10; Glucose-induced degradation protein 9; Probable E3 ubiquitin-protein ligase GID9", "protein_names_refseq": "glucose-induced degradation complex subunit FYV10", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL097W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12663529;12686616;14562095;14562106;16872538;17322287;18508925;19779198;22044534;22645139;24374639;31708416;33481703;33491328;33905682;38113892;9169870", "class_list": "", "function": "Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations (PubMed:12686616, PubMed:22044534, PubMed:31708416). Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:31708416). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes (PubMed:12686616, PubMed:22044534, PubMed:22645139). May catalyze ubiquitination of target proteins in complex with RMD5 (Probable). Required for survival upon exposure to K1 killer toxin (PubMed:12663529)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVJ0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034657 GID complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P40492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40857-1", "uniprot_id": "HACD_YEAST", "mass": 24511.0, "length": 217, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PHS1", "gene_name": "PHS1", "organism": "Yeast", "refseq_name": "enoyl-CoA hydratase PHS1", "refseq_ac": "NP_012438", "gene_names_uniprotkb": "PHS1; J0902", "gene_names_refseq": "PHS1", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PHS1; 3-hydroxyacyl-CoA dehydratase PHS1; 4.2.1.134; HACD; PTPLA homolog involved in sphingolipid biosynthesis protein 1", "protein_names_refseq": "enoyl-CoA hydratase PHS1", "tax_id": 559292, "disease": "congenital myopathy (Disease Ontology:DOID:0081337); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YJL097W); (R-SCE-75876)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;16847258;17322287;17719544;18272525;23416297;24374639;7871887;8641269", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW87", "ec_number_list": "4.2.1.134", "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0007034 vacuolar transport;GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40857-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41814-1", "uniprot_id": "TRM6_YEAST", "mass": 54389.0, "length": 478, "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "GCD10", "organism": "Yeast", "refseq_name": "tRNA 1-methyladenosine methyltransferase subunit GCD10", "refseq_ac": "NP_014337", "gene_names_uniprotkb": "GCD10; N2422; TIF33; TRM6", "gene_names_refseq": "GCD10; TRM6", "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; General control non-derepressible protein 10; Protein GCD10; tRNA(m1A58)-methyltransferase subunit TRM6; tRNA(m1A58)MTase subunit TRM6", "protein_names_refseq": "tRNA 1-methyladenosine methyltransferase subunit GCD10", "tax_id": 559292, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (sce:YNL062C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10779558;14562106;17563356;18407956;19795423;19823750;21126336;23749301;24374639;27582183;32597660;33481703;33491328;7542616;8533472;9169873;9851972", "class_list": "", "function": "Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:10779558, PubMed:9851972). Also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency (PubMed:7542616)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1B8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031515 tRNA (m1A) methyltransferase complex", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P41814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42935-1", "uniprot_id": "ELP2_YEAST", "mass": 89411.0, "length": 788, "protein_name": "Elongator complex protein 2", "gene_name": "ELP2", "organism": "Yeast", "refseq_name": "Elongator subunit ELP2", "refseq_ac": "NP_011716", "gene_names_uniprotkb": "ELP2; G7725; TOT2", "gene_names_refseq": "ELP2; KTI3; TOT2", "protein_names_uniprotkb": "Elongator complex protein 2; Gamma-toxin target 2", "protein_names_refseq": "Elongator subunit ELP2", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 58 (Disease Ontology:DOID:0081220); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (sce:YGR200C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10024884;11296232;11435442;11689709;11904415;12139626;13680368;14562095;14562106;15138274;15769872;15780940;17287358;17322287;18627462;18755837;22343726;24374639;25569479;25960406;27694803;27872205;27974378;29332244;31309145;33491328;8904340;9169869", "class_list": "", "function": "Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837, PubMed:31309145). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368). ELP2 binds to microtubules (PubMed:25960406). Independently, ELP2 may be involved in polarized exocytosis (PubMed:15138274, PubMed:15780940)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUY2;E9P8V1", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0015031 protein transport;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P42935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43585-1", "uniprot_id": "VTC2_YEAST", "mass": 95441.0, "length": 828, "protein_name": "Vacuolar transporter chaperone complex subunit 2", "gene_name": "VTC2", "organism": "Yeast", "refseq_name": "vacuolar transporter chaperone", "refseq_ac": "NP_116651", "gene_names_uniprotkb": "VTC2; PHM1", "gene_names_refseq": "PHM1; VTC2", "protein_names_uniprotkb": "Vacuolar transporter chaperone complex subunit 2; Phosphate metabolism protein 1; PolyP polymerase; SPX-dependent polyphosphate polymerase VTC subunit 2; Vacuolar membrane polyphosphate polymerase accessory subunit 2", "protein_names_refseq": "vacuolar transporter chaperone", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL004W)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10480897;11102525;11823419;12584253;14562106;15665377;16847258;17079729;17287358;17330950;17563356;18407956;19390046;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;25315834;27080106;27587415;28186404;30516470;32597660;33481703;33491328;34965436;7670463;8789262", "class_list": "", "function": "Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:19390046, PubMed:25315834). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106). The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTM5", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0000822 inositol hexakisphosphate binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007034 vacuolar transport;GO:0042144 vacuole fusion, non-autophagic;GO:0008104 intracellular protein localization;GO:0061736 engulfment of target by autophagosome;GO:0006797 polyphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P43585-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46959-1", "uniprot_id": "TRM61_YEAST", "mass": 43920.0, "length": 383, "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61", "gene_name": "GCD14", "organism": "Yeast", "refseq_name": "tRNA 1-methyladenosine methyltransferase subunit GCD14", "refseq_ac": "NP_012410", "gene_names_uniprotkb": "GCD14; J0710; TRM61", "gene_names_refseq": "GCD14; TRM61", "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; 2.1.1.220; General control non-derepressible protein 14; Protein GCD14; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)MTase subunit TRM61", "protein_names_refseq": "tRNA 1-methyladenosine methyltransferase subunit GCD14", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL125C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10779558;14562106;18407956;19779198;23749301;24374639;27582183;33481703;33491328;8641269;8948101;9539420;9851972", "class_list": "", "function": "Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:10779558, PubMed:9851972). GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency (PubMed:9539420)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VW61", "ec_number_list": "2.1.1.220", "go_molecular_function": "GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031515 tRNA (m1A) methyltransferase complex", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P46959-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50076-1", "uniprot_id": "ALG10_YEAST", "mass": 61793.0, "length": 525, "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "DIE2", "organism": "Yeast", "refseq_name": "dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase", "refseq_ac": "NP_011743", "gene_names_uniprotkb": "DIE2; ALG10; G8547", "gene_names_refseq": "ALG10; DIE2", "protein_names_uniprotkb": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; 2.4.1.256; Alpha-1,2-glucosyltransferase ALG10-A; Alpha-2-glucosyltransferase ALG10; Asparagine-linked glycosylation protein 10; Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10", "protein_names_refseq": "dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase", "tax_id": 559292, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); long QT syndrome 2 (Disease Ontology:DOID:0110645)", "pathway": " (sce:YGR227W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24374639;7565092;8701610;9169869;9597543", "class_list": "", "function": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VV08", "ec_number_list": "2.4.1.256", "go_molecular_function": "GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity;GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50076-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52491-1", "uniprot_id": "UBC12_YEAST", "mass": 21203.0, "length": 188, "protein_name": "NEDD8-conjugating enzyme UBC12", "gene_name": "UBC12", "organism": "Yeast", "refseq_name": "NEDD8-conjugating protein UBC12", "refseq_ac": "NP_013409", "gene_names_uniprotkb": "UBC12; L2142.3", "gene_names_refseq": "UBC12", "protein_names_uniprotkb": "NEDD8-conjugating enzyme UBC12; 2.3.2.34; RUB1-conjugating enzyme; Ubiquitin carrier protein 12", "protein_names_refseq": "NEDD8-conjugating protein UBC12", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR306W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21940857;24374639;9169871;9545234", "class_list": "", "function": "Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins. The major substrate is CDC53/Cullin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYU9", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53144-1", "uniprot_id": "YGK1_YEAST", "mass": 25297.0, "length": 215, "protein_name": "5'-deoxynucleotidase YGK1", "gene_name": "YGK1", "organism": "Yeast", "refseq_name": "5'-deoxynucleotidase", "refseq_ac": "NP_011414", "gene_names_uniprotkb": "YGK1", "gene_names_refseq": "YGK1", "protein_names_uniprotkb": "5'-deoxynucleotidase YGK1; 3.1.3.89", "protein_names_refseq": "5'-deoxynucleotidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL101W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;24374639;29752939;9169869;9290212", "class_list": "", "function": "Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU44", "ec_number_list": "3.1.3.89", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0002953 5'-deoxynucleotidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009159 deoxyribonucleoside monophosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53144-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53230-1", "uniprot_id": "TAM41_YEAST", "mass": 44200.0, "length": 385, "protein_name": "Phosphatidate cytidylyltransferase, mitochondrial", "gene_name": "TAM41", "organism": "Yeast", "refseq_name": "putative phosphatidate cytidylyltransferase", "refseq_ac": "NP_011560", "gene_names_uniprotkb": "TAM41; MMP37", "gene_names_refseq": "MMP37; TAM41", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase, mitochondrial; 2.7.7.41; CDP-DAG synthase; CDP-diacylglycerol synthase; Mitochondrial import protein MMP37; Mitochondrial matrix protein of 37 kDa; Mitochondrial translocator assembly and maintenance protein 41", "protein_names_refseq": "putative phosphatidate cytidylyltransferase", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 56 (Disease Ontology:DOID:0070429); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YGR046W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14690591;16273108;16790493;16943180;19114592;20485265;23623749;24374639;9169869", "class_list": "", "function": "Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUI3;Q45U38", "ec_number_list": "2.7.7.41", "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53290-1", "uniprot_id": "RAGCD_YEAST", "mass": 38600.0, "length": 341, "protein_name": "GTP-binding protein GTR2", "gene_name": "GTR2", "organism": "Yeast", "refseq_name": "Gtr2p", "refseq_ac": "NP_011679", "gene_names_uniprotkb": "GTR2", "gene_names_refseq": "GTR2", "protein_names_uniprotkb": "GTP-binding protein GTR2; 3.6.5.-", "protein_names_refseq": "Gtr2p", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); follicular lymphoma (Disease Ontology:DOID:0050873); renal hypomagnesemia 7, with or without dilated cardiomyopathy (Disease Ontology:DOID:0060972); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (sce:YGR163W); (R-SCE-165159); (R-SCE-9639288)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "14562095;14562106;15989961;16732272;19823750;21816923;24374639;26510498;28993463;32801125;33491328;9169869;9290212", "class_list": "", "function": "GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (PubMed:15989961, PubMed:26510498, PubMed:28993463, PubMed:32801125). Also required for TORC1 inactivation during nitrogen starvation (PubMed:28993463). Required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Involved in the regulation of microautophagy (PubMed:15989961)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUU7", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.1.-.-;7.1.2.2;3.6.5.4;3.6.5.5;2.7.1.67;2.7.11.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045121 membrane raft;GO:0031902 late endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010507 negative regulation of autophagy;GO:0034599 cellular response to oxidative stress;GO:0032008 positive regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53290-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53318-1", "uniprot_id": "COQ6_YEAST", "mass": 53527.0, "length": 479, "protein_name": "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial", "gene_name": "COQ6", "organism": "Yeast", "refseq_name": "putative N,N-dimethylaniline monooxygenase COQ6", "refseq_ac": "NP_011771", "gene_names_uniprotkb": "COQ6; G9165", "gene_names_refseq": "COQ6", "protein_names_uniprotkb": "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; 1.14.15.45; 1.14.15.46; 2-methoxy-6-polyprenolphenol 4-hydroxylase; 3.5.-.-; Ubiquinone C4-deaminase", "protein_names_refseq": "putative N,N-dimethylaniline monooxygenase COQ6", "tax_id": 559292, "disease": "primary coenzyme Q10 deficiency 6 (Disease Ontology:DOID:0070243); nephrotic syndrome (Disease Ontology:DOID:1184); schwannomatosis (Disease Ontology:DOID:3204)", "pathway": " (sce:YGR255C); (R-SCE-2142789)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12721307;14562106;14576278;17391640;21944752;24374639;24406904;26260787;26808124;9133741;9169869", "class_list": "", "function": "FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-hexaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-hexaprenyl)benzoic acid (PubMed:21944752). Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-hexaprenyl)phenol to 2-methoxy-6-(all-trans-hexaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6 (PubMed:21944752). Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a two step process (PubMed:26260787). HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB (PubMed:26260787)., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV35;Q05674;Q05675", "ec_number_list": "4.1.1.130;2.1.1.-;2.1.1.114;2.1.1.64;2.7.-.-;1.14.99.60;1.14.13.253;2.1.1.201;3.5.-.-;1.14.15.45;1.14.15.46", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008681 2-octaprenyl-6-methoxyphenol hydroxylase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00582-1", "uniprot_id": "RAGAB_YEAST", "mass": 35847.0, "length": 310, "protein_name": "GTP-binding protein GTR1", "gene_name": "GTR1", "organism": "Yeast", "refseq_name": "Rag GTPase GTR1", "refseq_ac": "NP_013585", "gene_names_uniprotkb": "GTR1; YM7056.05", "gene_names_refseq": "GTR1", "protein_names_uniprotkb": "GTP-binding protein GTR1; 3.6.5.-", "protein_names_refseq": "Rag GTPase GTR1", "tax_id": 559292, "disease": "ragopathy (Disease Ontology:DOID:0061140)", "pathway": " (sce:YML121W); (R-SCE-165159); (R-SCE-9639288)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "14562106;1620108;16732272;17322287;21816923;24374639;26510498;28483912;28993463;29698392;32801125;9169872", "class_list": "", "function": "GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (PubMed:26510498, PubMed:28993463, PubMed:32801125). Also required for TORC1 inactivation during nitrogen starvation (PubMed:28993463). Required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Functionally associated with the inorganic phosphate transporter PHO84, and may be involved in regulating its function or localization (PubMed:1620108)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0G3", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.1.-.-;7.1.2.2;3.6.5.4;3.6.5.5;2.7.1.67;2.7.11.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006360 transcription by RNA polymerase I;GO:0031509 subtelomeric heterochromatin formation;GO:0010507 negative regulation of autophagy;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q00582-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02201-1", "uniprot_id": "OSH6_YEAST", "mass": 51588.0, "length": 448, "protein_name": "Oxysterol-binding protein homolog 6", "gene_name": "OSH6", "organism": "Yeast", "refseq_name": "oxysterol-binding protein OSH6", "refseq_ac": "NP_012928", "gene_names_uniprotkb": "OSH6; YK102", "gene_names_refseq": "OSH6", "protein_names_uniprotkb": "Oxysterol-binding protein homolog 6; LTP; Lipid-transfer protein Osh6; ORP 6; OSBP-related protein 6; Oxysterol-binding phosphatidylserine transferase; Oxysterol-binding protein-related protein 6", "protein_names_refseq": "oxysterol-binding protein OSH6", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR003W); (R-SCE-1482801); (R-SCE-192105)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "11238399;1441752;14562106;15173322;16096648;16156791;17287358;19795423;19823750;20008566;22814378;23749301;23934110;24374639;26206936;30516470;32597660;33481703;33491328;8196765", "class_list": "", "function": "Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322, PubMed:16156791, PubMed:23934110, PubMed:26206936). Catalyzes the lipid countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM). Specifically exchanges phosphatidylserine (PS) with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport (PubMed:23934110, PubMed:26206936). Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936). Also binds phosphatidic acid (PA) (PubMed:16156791)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT9", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015914 phospholipid transport;GO:0016125 sterol metabolic process;GO:0006887 exocytosis;GO:0030011 maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q02201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02884-1", "uniprot_id": "ELP4_YEAST", "mass": 51156.0, "length": 456, "protein_name": "Elongator complex protein 4", "gene_name": "ELP4", "organism": "Yeast", "refseq_name": "Elongator subunit ELP4", "refseq_ac": "NP_015224", "gene_names_uniprotkb": "ELP4; HAP1; TOT7", "gene_names_refseq": "ELP4; HAP1; KTI9; TOT7", "protein_names_uniprotkb": "Elongator complex protein 4; Gamma-toxin target 7; HAT-associated protein 1", "protein_names_refseq": "Elongator subunit ELP4", "tax_id": 559292, "disease": "aniridia (Disease Ontology:DOID:12271)", "pathway": " (sce:YPL101W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10024884;11296232;11390369;11435442;11689709;11904415;13680368;14562106;15138274;15769872;15772087;15780940;17330950;18407956;18755837;19779198;20702584;22343726;22556426;24374639;25569479;26046779;27872205;27974378;29332244;31309145;32597660;33481703;33491328;9169875", "class_list": "", "function": "Component of the elongator complex, a multiprotein complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3R5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q02884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02908-1", "uniprot_id": "ELP3_YEAST", "mass": 63657.0, "length": 557, "protein_name": "Elongator complex protein 3", "gene_name": "ELP3", "organism": "Yeast", "refseq_name": "Elongator subunit ELP3", "refseq_ac": "NP_015239", "gene_names_uniprotkb": "ELP3; HPA1; TOT3", "gene_names_refseq": "ELP3; HPA1; KAT9; KTI8; TOT3", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.311; Gamma-toxin target 3; tRNA uridine(34) acetyltransferase", "protein_names_refseq": "Elongator subunit ELP3", "tax_id": 559292, "disease": "familial dysautonomia (Disease Ontology:DOID:11589)", "pathway": " (sce:YPL086C)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10024884;10445034;11296232;11435442;11689709;11904415;12872131;13680368;14562095;14562106;15138274;15769872;15772087;15780940;16420352;17018299;18627462;18755837;18986986;19779198;21912530;22343726;23749301;24374639;25960406;27455459;27694803;27872205;27974378;31309145;33481703;33491328;9169875", "class_list": "", "function": "Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:17018299, PubMed:18755837, PubMed:21912530, PubMed:31309145). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). The complex functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368). Independently, ELP3 may be involved in polarized exocytosis (PubMed:15780940)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3T1", "ec_number_list": "2.3.1.311", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0106261 tRNA uridine(34) acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0002098 tRNA wobble uridine modification;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q02908-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03921-1", "uniprot_id": "DOP1_YEAST", "mass": 194688.0, "length": 1698, "protein_name": "Protein DOP1", "gene_name": "DOP1", "organism": "Yeast", "refseq_name": "Dop1p", "refseq_ac": "NP_010425", "gene_names_uniprotkb": "DOP1; YD9302.17C", "gene_names_refseq": "DOP1", "protein_names_uniprotkb": "Protein DOP1", "protein_names_refseq": "Dop1p", "tax_id": 559292, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (sce:YDR141C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10931277;14562095;14562106;16219684;16301316;17330950;17563356;18407956;19779198;21126336;23749301;24374639;28404745;32597660;33481703;33491328;9169867", "class_list": "", "function": "Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum (PubMed:16301316). Required for normal cellular morphogenesis (PubMed:10931277)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSC4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0000902 cell morphogenesis;GO:0042147 retrograde transport, endosome to Golgi;GO:0006895 Golgi to endosome transport;GO:0000301 retrograde transport, vesicle recycling within Golgi", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03921-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04305-1", "uniprot_id": "UTP15_YEAST", "mass": 57686.0, "length": 513, "protein_name": "U3 small nucleolar RNA-associated protein 15", "gene_name": "UTP15", "organism": "Yeast", "refseq_name": "snoRNA-binding rRNA-processing protein UTP15", "refseq_ac": "NP_013811", "gene_names_uniprotkb": "UTP15; YM9582.18", "gene_names_refseq": "UTP15", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 15; U three protein 15; U3 protein 15 required for transcription; U3 snoRNA-associated protein 15; t-UTP15", "protein_names_refseq": "snoRNA-binding rRNA-processing protein UTP15", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR093W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12068309;14562106;15489292;18407956;24374639;33481703;33491328;9169872", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZR6", "ec_number_list": "", "go_molecular_function": "GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0033553 rDNA heterochromatin;GO:0034455 t-UTP complex;GO:0030686 90S preribosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04868-1", "uniprot_id": "ELP6_YEAST", "mass": 30574.0, "length": 273, "protein_name": "Elongator complex protein 6", "gene_name": "ELP6", "organism": "Yeast", "refseq_name": "Elongator subunit ELP6", "refseq_ac": "NP_014043", "gene_names_uniprotkb": "ELP6; HAP3; TOT6; YM9924.04", "gene_names_refseq": "ELP6; HAP3; KTI4; TOT6", "protein_names_uniprotkb": "Elongator complex protein 6; Gamma-toxin target 6; HAT-associated protein 3", "protein_names_refseq": "Elongator subunit ELP6", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR312W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10024884;11296232;11390369;11435442;11689709;11904415;13680368;15769872;15780940;17322287;18755837;22343726;22556426;24374639;27872205;27974378;29332244;31309145;33491328;9169872", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:11296232). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q04868-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06706-1", "uniprot_id": "ELP1_YEAST", "mass": 152990.0, "length": 1349, "protein_name": "Elongator complex protein 1", "gene_name": "IKI3", "organism": "Yeast", "refseq_name": "Elongator subunit IKI3", "refseq_ac": "NP_013488", "gene_names_uniprotkb": "IKI3; ELP1; L3502.7; TOT1", "gene_names_refseq": "ELP1; IKI3; KTI7; TOT1", "protein_names_uniprotkb": "Elongator complex protein 1; Gamma-toxin target 1; Protein IKI3", "protein_names_refseq": "Elongator subunit IKI3", "tax_id": 559292, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); medulloblastoma (Disease Ontology:DOID:0050902); scoliosis (Disease Ontology:DOID:0060249); familial dysautonomia (Disease Ontology:DOID:11589); asthma (Disease Ontology:DOID:2841); kyphosis (Disease Ontology:DOID:4667)", "pathway": " (sce:YLR384C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10024884;11296232;11435442;11689709;11904415;12139626;12424236;13680368;14562095;14562106;15769872;15780940;18755837;22343726;24374639;24750273;25569479;25960406;26261306;27694803;27872205;27974378;29332244;31309145;32597660;33481703;33491328;9145530;9169871", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837, PubMed:25569479, PubMed:31309145). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:12424236). May also be involved in sensitivity to Pichia inositovora toxin (PubMed:13680368). ELP1/IKI3 binds to tRNA, mediating interaction of the elongator complex with tRNA (PubMed:24750273). Independently, may be involved in polarized exocytosis (PubMed:15780940)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ19;O00036", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0015031 protein transport;GO:0002098 tRNA wobble uridine modification;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q06706-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06833-1", "uniprot_id": "NVJ2_YEAST", "mass": 87324.0, "length": 770, "protein_name": "Nucleus-vacuole junction protein 2", "gene_name": "NVJ2", "organism": "Yeast", "refseq_name": "Nvj2p", "refseq_ac": "NP_015416", "gene_names_uniprotkb": "NVJ2", "gene_names_refseq": "NVJ2", "protein_names_uniprotkb": "Nucleus-vacuole junction protein 2", "protein_names_refseq": "Nvj2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR091C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "14562095;14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22250200;23749301;24374639;24909858;28011845;30516470;32597660;33229814;33481703;33491328;36897280;9169875", "class_list": "", "function": "During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, induces contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation., [UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6W491", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0035621 ER to Golgi ceramide transport", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q06833-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07914-1", "uniprot_id": "TIM14_YEAST", "mass": 17910.0, "length": 168, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM14", "gene_name": "PAM18", "organism": "Yeast", "refseq_name": "Pam18p", "refseq_ac": "NP_013108", "gene_names_uniprotkb": "PAM18; TIM14", "gene_names_refseq": "PAM18; TIM14", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM14; Presequence translocated-associated motor subunit PAM18", "protein_names_refseq": "Pam18p", "tax_id": 559292, "disease": "3-methylglutaconic aciduria type 5 (Disease Ontology:DOID:0110000)", "pathway": " (sce:YLR008C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14517234;14605210;14638855;14981507;15218029;16105940;16107694;17322287;24374639;9169871", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY10", "ec_number_list": "", "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q07914-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08484-1", "uniprot_id": "GYP1_YEAST", "mass": 73289.0, "length": 637, "protein_name": "GTPase-activating protein GYP1", "gene_name": "GYP1", "organism": "Yeast", "refseq_name": "GTPase-activating protein GYP1", "refseq_ac": "NP_014713", "gene_names_uniprotkb": "GYP1; YOR29-21", "gene_names_refseq": "GYP1; YOR29-21", "protein_names_uniprotkb": "GTPase-activating protein GYP1; GAP for YPT1", "protein_names_refseq": "GTPase-activating protein GYP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR070C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10508155;11013213;11118206;11359917;14562106;16855591;17563356;18407956;19386605;19684113;19779198;20702584;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9133743;9169874", "class_list": "", "function": "GTPase-activating protein (GAP) that stimulates specifically the intrinsic GTPase activity of Ypt/Rab-type GTPases YPT1 and YPT7 (PubMed:11359917, PubMed:19386605). Functions on the Golgi as a negative regulator of YPT1 (PubMed:11359917). Functions on the vacuole as a negative regulator of YPT7 (PubMed:11118206, PubMed:19386605). It is also active on SEC4 and YPT51 (PubMed:10508155). Provides a catalytic arginine (arginine finger) and glutamine (glutamine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable) (PubMed:16855591)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W2D3;O00028", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005795 Golgi stack", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q08484-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12068-1", "uniprot_id": "GRE2_YEAST", "mass": 38170.0, "length": 342, "protein_name": "NADPH-dependent methylglyoxal reductase GRE2", "gene_name": "GRE2", "organism": "Yeast", "refseq_name": "methylglyoxal reductase (NADPH-dependent) GRE2", "refseq_ac": "NP_014490", "gene_names_uniprotkb": "GRE2", "gene_names_refseq": "GRE2", "protein_names_uniprotkb": "NADPH-dependent methylglyoxal reductase GRE2; 1.1.1.265; 1.1.1.283; 3-methylbutanal reductase; Genes de respuesta a estres protein 2; Isovaleraldehyde reductase", "protein_names_refseq": "methylglyoxal reductase (NADPH-dependent) GRE2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL151W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10347154;10407268;11401713;12722185;14562095;14562106;16598690;16999827;17322287;18407956;20111861;20237665;20480039;21126336;24374639;24879127;33481703;33491328;3896793;8553699;9169874", "class_list": "", "function": "Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde as an alternative to detoxification of MG by glyoxalase I GLO1. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation (PubMed:12722185, PubMed:3896793). Also catalyzes the reduction of 3-methylbutanal to 3-methylbutanol. Acts as a suppressor of 3-methylbutanol-induced filamentation by modulating the levels of 3-methylbutanal, the signal to which cells respond by filamentation (PubMed:16999827). Also involved in ergosterol metabolism (PubMed:16598690)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1R9", "ec_number_list": "1.1.1.2;1.6.-.-;1.1.1.265;1.1.1.283", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0043892 methylglyoxal reductase (NADPH) activity;GO:0046568 3-methylbutanal reductase [NAD(P)H] activity;GO:0052675 3-methylbutanal reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0008204 ergosterol metabolic process;GO:0030447 filamentous growth", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12068-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28737-1", "uniprot_id": "MSP1_YEAST", "mass": 40343.0, "length": 362, "protein_name": "Outer mitochondrial transmembrane helix translocase", "gene_name": "MSP1", "organism": "Yeast", "refseq_name": "protein-degrading AAA family ATPase MSP1", "refseq_ac": "NP_011542", "gene_names_uniprotkb": "MSP1; YTA4", "gene_names_refseq": "MSP1; YTA4", "protein_names_uniprotkb": "Outer mitochondrial transmembrane helix translocase; 7.4.2.-; Mitochondrial sorting of proteins; Tat-binding homolog 4", "protein_names_refseq": "protein-degrading AAA family ATPase MSP1", "tax_id": 559292, "disease": "hyperekplexia 4 (Disease Ontology:DOID:0080581)", "pathway": " (sce:YGR028W); (R-SCE-9603798)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;1552903;17322287;24374639;24440502;24821790;24843043;28712723;28906250;30858337;31445887;32541053;33491328;7754704;8226973;9169869;9290212", "class_list": "", "function": "Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24821790, PubMed:24843043, PubMed:28712723, PubMed:28906250, PubMed:30858337, PubMed:31445887). Specifically recognizes and binds exposed hydrophobic surfaces of mistargeted tail-anchored transmembrane proteins (PubMed:30858337). Acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (PubMed:24821790, PubMed:24843043, PubMed:28712723, PubMed:28906250, PubMed:30858337, PubMed:32541053). Able to unfold protein substrates by processive threading through its central pore (PubMed:32541053). Once extracted from the mitochondrion outer membrane, substrate proteins are then transferred to the endoplasmic reticulum, where they are ubiquitinated and degraded by the proteasome (PubMed:31445887). Also mediates extraction of excess tail-anchored proteins from the peroxisomal membrane (PubMed:28906250). In normal conditions, MSP1 translocase activity is inhibited by PEX3 at peroxisomes; only catalyzes removal of excess tail-anchored proteins (PubMed:28906250)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUG3", "ec_number_list": "7.4.2.-;1.2.1.3;1.2.1.64", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140567 membrane protein dislocase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006626 protein targeting to mitochondrion;GO:0045047 protein targeting to ER;GO:0034214 protein hexamerization;GO:0140570 extraction of mislocalized protein from mitochondrial outer membrane", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P28737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29311-1", "uniprot_id": "BMH1_YEAST", "mass": 30091.0, "length": 267, "protein_name": "Protein BMH1", "gene_name": "BMH1", "organism": "Yeast", "refseq_name": "14-3-3 family protein BMH1", "refseq_ac": "NP_011104", "gene_names_uniprotkb": "BMH1", "gene_names_refseq": "APR6; BMH1", "protein_names_uniprotkb": "Protein BMH1", "protein_names_refseq": "14-3-3 family protein BMH1", "tax_id": 559292, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); left ventricular noncompaction (Disease Ontology:DOID:0060480)", "pathway": " (sce:YER177W); (R-SCE-3371453); (R-SCE-3371511); (R-SCE-5625740); (R-SCE-75035)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "12551942;1378790;14562106;17287358;19779198;19795423;19805817;19823750;19860830;20702584;21126336;21177495;22106047;22320399;23749301;24374639;24909858;29087344;30516470;33441790;33481703;33491328;9169868;9298649", "class_list": "", "function": "Involved in growth regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM86;Q06854", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0008047 enzyme activator activity;GO:0050815 phosphoserine residue binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P29311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32337-1", "uniprot_id": "IMB3_YEAST", "mass": 121031.0, "length": 1089, "protein_name": "Importin subunit beta-3", "gene_name": "PSE1", "organism": "Yeast", "refseq_name": "importin PSE1", "refseq_ac": "NP_014039", "gene_names_uniprotkb": "PSE1; KAP121; YM9952.10C", "gene_names_refseq": "KAP121; PSE1", "protein_names_uniprotkb": "Importin subunit beta-3; Karyopherin subunit beta-3; Karyopherin-121; Protein secretion enhancer 1", "protein_names_refseq": "importin PSE1", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YMR308C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11274141;11423015;11694505;14562106;1522152;15367670;15522095;19779198;22814378;23541588;24374639;33491328;9169872;9182759;9238021;9321403", "class_list": "", "function": "Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for classical and arginine/glycine-rich nuclear localization signals (cNLS and rg-NLS) in cargo substrates (PubMed:15367670). Its predominant cargo substrate seems to be ribosomal proteins and ribosome biogenesis trans- and cis-acting factors (PubMed:15367670, PubMed:9182759, PubMed:9321403). Required for nuclear transport of YAP1, NOP1 and SOF1 (PubMed:11274141, PubMed:15367670). Mediates the nuclear import of histones H3 and H4 (PubMed:11694505). Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015). At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo (PubMed:9321403). The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Plays a role in protein secretion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D5", "ec_number_list": "", "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0007088 regulation of mitotic nuclear division;GO:0006606 protein import into nucleus;GO:0060188 regulation of protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32357-1", "uniprot_id": "AAR2_YEAST", "mass": 41688.0, "length": 355, "protein_name": "A1 cistron-splicing factor AAR2", "gene_name": "AAR2", "organism": "Yeast", "refseq_name": "U5 snRNP complex subunit AAR2", "refseq_ac": "NP_009479", "gene_names_uniprotkb": "AAR2; YBL06.06; YBL0611", "gene_names_refseq": "AAR2", "protein_names_uniprotkb": "A1 cistron-splicing factor AAR2", "protein_names_refseq": "U5 snRNP complex subunit AAR2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL074C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11720285;14562106;18407956;1922071;19779198;21764848;2188113;23354046;24374639;33481703;33491328;7813418;7992509", "class_list": "", "function": "Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPS8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005682 U5 snRNP", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32357-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32361-1", "uniprot_id": "IRE1_YEAST", "mass": 126976.0, "length": 1115, "protein_name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "gene_name": "IRE1", "organism": "Yeast", "refseq_name": "bifunctional endoribonuclease/protein kinase IRE1", "refseq_ac": "NP_011946", "gene_names_uniprotkb": "IRE1; ERN1", "gene_names_refseq": "ERN1; IRE1", "protein_names_uniprotkb": "Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1", "protein_names_refseq": "bifunctional endoribonuclease/protein kinase IRE1", "tax_id": 559292, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); oropharynx cancer (Disease Ontology:DOID:8557)", "pathway": " (sce:YHR079C); (R-SCE-381070)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "14562106;1625574;16365312;16990850;18191223;19779198;20489023;21317875;23749301;24374639;28559428;32597660;33481703;33491328;33502312;33627709;8091229;8358794;8663458;8670804;9323131;9528768", "class_list": "", "function": "Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:8663458, PubMed:8670804, PubMed:9528768). The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes (PubMed:18191223, PubMed:9323131)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D3DL29", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0036498 IRE1-mediated unfolded protein response;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32368-1", "uniprot_id": "SAC1_YEAST", "mass": 71125.0, "length": 623, "protein_name": "Phosphatidylinositol-3-phosphatase SAC1", "gene_name": "SAC1", "organism": "Yeast", "refseq_name": "phosphatidylinositol-3-phosphatase SAC1", "refseq_ac": "NP_012710", "gene_names_uniprotkb": "SAC1; RSD1", "gene_names_refseq": "RSD1; SAC1", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphatase SAC1; 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Recessive suppressor of secretory defect", "protein_names_refseq": "phosphatidylinositol-3-phosphatase SAC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL212W); (R-SCE-1483248); (R-SCE-1660514); (R-SCE-1660516)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10625610;11514624;11792713;14562106;16847258;20182505;22106047;24374639;2687291;33481703;33491328;7941750;8196765;8314848", "class_list": "", "function": "Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:10625610, PubMed:11792713). Has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10625610). May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton (PubMed:11514624)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ1", "ec_number_list": "3.1.3.64", "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:0090156 intracellular sphingolipid homeostasis;GO:0061909 autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32776-1", "uniprot_id": "TFB1_YEAST", "mass": 72894.0, "length": 642, "protein_name": "General transcription and DNA repair factor IIH subunit TFB1", "gene_name": "TFB1", "organism": "Yeast", "refseq_name": "TFIIH/NER complex subunit TFB1", "refseq_ac": "NP_010597", "gene_names_uniprotkb": "TFB1; D9740.3", "gene_names_refseq": "TFB1", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH subunit TFB1; RNA polymerase II transcription factor B 73 kDa subunit; RNA polymerase II transcription factor B p73 subunit; RNA polymerase II transcription factor B subunit 1; TFIIH subunit TFB1", "protein_names_refseq": "TFIIH/NER complex subunit TFB1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR311W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 14, "publication_id_list": "1445600;14500720;14562106;17322287;18407956;22373916;22411836;23295669;24374639;33491328;7813015;7961739;8631896;9169867", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSU0;E9P948", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005675 transcription factor TFIIH holo complex;GO:0000112 nucleotide-excision repair factor 3 complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006281 DNA repair;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32791-1", "uniprot_id": "FRE1_YEAST", "mass": 78854.0, "length": 686, "protein_name": "Ferric/cupric reductase transmembrane component 1", "gene_name": "FRE1", "organism": "Yeast", "refseq_name": "ferric/cupric-chelate reductase", "refseq_ac": "NP_013315", "gene_names_uniprotkb": "FRE1; L8167.2", "gene_names_refseq": "FRE1", "protein_names_uniprotkb": "Ferric/cupric reductase transmembrane component 1; 1.16.1.9; Ferric-chelate reductase 1", "protein_names_refseq": "ferric/cupric-chelate reductase", "tax_id": 559292, "disease": "chronic granulomatous disease (Disease Ontology:DOID:3265)", "pathway": " (sce:YLR214W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10341420;11120744;12954629;1431884;14562106;15288128;1570306;16000801;16024809;17507646;24374639;33481703;33491328;7720713;7814363;8662826;8662973;8940093;9153234;9169871;9200812;9726978", "class_list": "", "function": "Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VYL5", "ec_number_list": "1.16.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0052851 ferric-chelate reductase (NADPH) activity;GO:0000293 ferric-chelate reductase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0015677 copper ion import;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32794-1", "uniprot_id": "AFG2_YEAST", "mass": 84748.0, "length": 780, "protein_name": "ATPase family gene 2 protein", "gene_name": "AFG2", "organism": "Yeast", "refseq_name": "AAA family ATPase AFG2", "refseq_ac": "NP_013501", "gene_names_uniprotkb": "AFG2; DRG1; L8084.16", "gene_names_refseq": "AFG2; DRG1", "protein_names_uniprotkb": "ATPase family gene 2 protein; 3.6.4.10; Diazaborine resistance gene 1 protein", "protein_names_refseq": "AAA family ATPase AFG2", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR397C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12006565;14562106;17322287;17646390;23185031;24371142;24374639;33491328;8109176;9169871", "class_list": "", "function": "ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (PubMed:12006565, PubMed:17646390, PubMed:23185031, PubMed:24371142). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RLP24 from the pre-ribosomal particles (PubMed:17646390, PubMed:23185031, PubMed:24371142). This step facilitates the subsequent release of other shuttling proteins such as NOG1 and allows the transition of the pre-ribosomal particles to later maturation forms that bind REI1 (PubMed:17646390, PubMed:23185031, PubMed:24371142). Essential for viability (PubMed:24371142, PubMed:8109176)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ32", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0009410 response to xenobiotic stimulus;GO:0034214 protein hexamerization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32794-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32799-1", "uniprot_id": "COX13_YEAST", "mass": 15021.0, "length": 129, "protein_name": "Cytochrome c oxidase subunit 13, mitochondrial", "gene_name": "COX13", "organism": "Yeast", "refseq_name": "cytochrome c oxidase subunit VIa", "refseq_ac": "NP_011324", "gene_names_uniprotkb": "COX13; G1341", "gene_names_refseq": "COX13", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 13, mitochondrial; Cytochrome c oxidase polypeptide VIa", "protein_names_refseq": "cytochrome c oxidase subunit VIa", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 18 (Disease Ontology:DOID:0070503); Charcot-Marie-Tooth disease recessive intermediate D (Disease Ontology:DOID:0110203); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (sce:YGL191W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10764779;10775262;1331058;17322287;24374639;30598554;30598556;7851399;8395517;9046087;9169869", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTW3", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0009060 aerobic respiration;GO:1902600 proton transmembrane transport;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32799-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32906-1", "uniprot_id": "MNS1_YEAST", "mass": 63057.0, "length": 549, "protein_name": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "gene_name": "MNS1", "organism": "Yeast", "refseq_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase", "refseq_ac": "NP_012665", "gene_names_uniprotkb": "MNS1; J2110", "gene_names_refseq": "MNS1", "protein_names_uniprotkb": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; 3.2.1.113; 3.2.1.209; ER alpha-1,2-mannosidase; Man(9)-alpha-mannosidase", "protein_names_refseq": "mannosyl-oligosaccharide 1,2-alpha-mannosidase", "tax_id": 559292, "disease": "Rafiq syndrome (Disease Ontology:DOID:0081097)", "pathway": " (sce:YJR131W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10675327;12090241;14562106;1714453;24374639;8641269", "class_list": "", "function": "Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations it further trims the carbohydrates to Man(5)GlcNAc(2)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VWU9", "ec_number_list": "3.2.1.113;3.2.1.209", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway;GO:0035977 protein deglycosylation involved in glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32906-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33201-1", "uniprot_id": "MRT4_YEAST", "mass": 27058.0, "length": 236, "protein_name": "Ribosome assembly factor MRT4", "gene_name": "MRT4", "organism": "Yeast", "refseq_name": "ribosome assembly factor MRT4", "refseq_ac": "NP_012916", "gene_names_uniprotkb": "MRT4; YKL160", "gene_names_refseq": "MRT4", "protein_names_uniprotkb": "Ribosome assembly factor MRT4; mRNA turnover protein 4", "protein_names_refseq": "ribosome assembly factor MRT4", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL009W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10471698;11583614;14562106;1481574;18407956;19346338;19789271;19797078;20702584;24374639;24662372;33481703;33491328;8196765;8488728", "class_list": "", "function": "Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXS7", "ec_number_list": "", "go_molecular_function": "GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0042273 ribosomal large subunit biogenesis;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P33201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33892-1", "uniprot_id": "GCN1_YEAST", "mass": 296698.0, "length": 2672, "protein_name": "eIF-2-alpha kinase activator GCN1", "gene_name": "GCN1", "organism": "Yeast", "refseq_name": "Gcn1p", "refseq_ac": "NP_011320", "gene_names_uniprotkb": "GCN1; G1318", "gene_names_refseq": "AAS103; GCN1; NDR1", "protein_names_uniprotkb": "eIF-2-alpha kinase activator GCN1; General control non-derepressible protein 1; Translational activator GCN1", "protein_names_refseq": "Gcn1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL195W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10733573;10775272;10801780;11101534;11350982;14562106;15126500;15722345;17330950;19448108;19779198;19795423;19823750;21239490;21849502;22404850;22888004;24333428;24374639;25437641;28526057;33338396;33481703;33491328;33790014;36441697;7621831;8497269;9046087;9169869;9234705", "class_list": "", "function": "Ribosome collision sensor that activates a translation quality control pathway when a ribosome has stalled during translation (PubMed:33790014). Directly binds to the ribosome and acts as a sentinel for colliding ribosomes (By similarity). GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of GCN2 in response to low amino acid, carbon, or purine availability (PubMed:10733573, PubMed:24333428, PubMed:33338396, PubMed:8497269). Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes: during this process, GCN1 acts as a chaperone to facilitate delivery of uncharged tRNAs that enter the A-site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) (PubMed:15722345, PubMed:36441697, PubMed:7621831, PubMed:9234705). eIF-2-alpha/SUI2 phosphorylation converts eIF-2-alpha/SUI2 into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator GCN4, and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:10801780, PubMed:11350982, PubMed:15722345, PubMed:8497269)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 37, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTV8", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019887 protein kinase regulator activity;GO:0043022 ribosome binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0043008 ATP-dependent protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0001934 positive regulation of protein phosphorylation;GO:0006417 regulation of translation;GO:0033674 positive regulation of kinase activity;GO:0006448 regulation of translational elongation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P33892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35844-1", "uniprot_id": "KES1_YEAST", "mass": 49492.0, "length": 434, "protein_name": "Oxysterol-binding protein homolog 4", "gene_name": "KES1", "organism": "Yeast", "refseq_name": "oxysterol-binding protein KES1", "refseq_ac": "NP_015180", "gene_names_uniprotkb": "KES1; BSR3; LPI3C; OSH4; P2614", "gene_names_refseq": "BSR3; KES1; LPI3; OSH4", "protein_names_uniprotkb": "Oxysterol-binding protein homolog 4; Bypass SECl4 recessive protein 3; KRE11-1 suppressor protein 1; ORP 4; OSBP-related protein 4; Oxysterol-binding protein-related protein 4; Protein KES1", "protein_names_refseq": "oxysterol-binding protein KES1", "tax_id": 559292, "disease": "autosomal dominant nonsyndromic deafness 67 (Disease Ontology:DOID:0110588); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (sce:YPL145C); (R-SCE-1482801); (R-SCE-192105)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "11238399;11916983;14562106;15173322;16136145;16585271;17220896;17322287;18407956;19779198;19795423;19823750;20008566;21126336;22162133;23749301;23756172;24213531;24374639;25849868;26206936;29487131;32597660;33481703;33491328;8017104;8948103;8978672;9169875", "class_list": "", "function": "Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322, PubMed:16136145, PubMed:20008566, PubMed:22162133). Involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum. Specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/Golgi interface, SAC1 may drive PS transport (PubMed:16136145, PubMed:22162133, PubMed:25849868). Displays a similar affinity for PI4P and sterols (PubMed:22162133). Binds sterol and PI4P in a mutually exclusive manner (PubMed:22162133). Involved in ergosterol transport from the plasma membrane (PM) to the ER (PubMed:16585271). Mediates sterol transport from the ER to mitochondria (PubMed:29487131). Involved in the negative regulation of Golgi-derived transport vesicle biogenesis (PubMed:8978672). Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos (PubMed:24213531)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3M4;E9P8U8", "ec_number_list": "", "go_molecular_function": "GO:0008142 oxysterol binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008289 lipid binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006665 sphingolipid metabolic process;GO:0006892 post-Golgi vesicle-mediated transport;GO:0006887 exocytosis;GO:0030011 maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P35844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36010-1", "uniprot_id": "NDK_YEAST", "mass": 17167.0, "length": 153, "protein_name": "Nucleoside diphosphate kinase", "gene_name": "YNK1", "organism": "Yeast", "refseq_name": "nucleoside diphosphate kinase", "refseq_ac": "NP_012856", "gene_names_uniprotkb": "YNK1; NDK1; YKL333; YNK", "gene_names_refseq": "NDK1; YNK1", "protein_names_uniprotkb": "Nucleoside diphosphate kinase; 2.7.4.6; NDK; NDP kinase", "protein_names_refseq": "nucleoside diphosphate kinase", "tax_id": 559292, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); ovary epithelial cancer (Disease Ontology:DOID:2152); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); teratoma (Disease Ontology:DOID:3307); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (sce:YKL067W); (R-SCE-499943); (R-SCE-6798695); (R-SCE-9748787); (R-SCE-9755088)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "12472466;14562106;1659321;16823961;16957983;17322287;18407956;18607079;18983998;22984289;23749301;24374639;33481703;33491328;4576138;5793714;8091863;8196765;8392963", "class_list": "", "function": "Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (PubMed:5793714). Required for repair of UV radiation- and etoposide-induced DNA damage (PubMed:18983998)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXM0", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0006183 GTP biosynthetic process;GO:0006228 UTP biosynthetic process;GO:0006241 CTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P36010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36077-1", "uniprot_id": "SRX1_YEAST", "mass": 13854.0, "length": 127, "protein_name": "Sulfiredoxin", "gene_name": "SRX1", "organism": "Yeast", "refseq_name": "sulfiredoxin", "refseq_ac": "NP_012837", "gene_names_uniprotkb": "SRX1", "gene_names_refseq": "SRX1", "protein_names_uniprotkb": "Sulfiredoxin; 1.8.98.2; Sulphiredoxin", "protein_names_refseq": "sulfiredoxin", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL086W); (R-SCE-9818027)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562095;14562106;14586471;17322287;24374639;33481703;33491328;8196765", "class_list": "", "function": "Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK2", "ec_number_list": "1.11.1.24;1.8.98.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0032542 sulfiredoxin activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0032272 negative regulation of protein polymerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P36077-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36152-1", "uniprot_id": "DRE2_YEAST", "mass": 38543.0, "length": 348, "protein_name": "Fe-S cluster assembly protein DRE2", "gene_name": "DRE2", "organism": "Yeast", "refseq_name": "electron carrier DRE2", "refseq_ac": "NP_012997", "gene_names_uniprotkb": "DRE2", "gene_names_refseq": "DRE2", "protein_names_uniprotkb": "Fe-S cluster assembly protein DRE2; Anamorsin homolog", "protein_names_refseq": "electron carrier DRE2", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR071C)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "12759774;14562095;14562106;16432255;17330950;17563356;18407956;18625724;19194512;19684113;19779198;19795423;19823750;20702584;20802492;21126336;21177495;21700214;21902732;21931161;22218487;22487307;23749301;24374639;24733891;27166425;27672211;30516470;31040179;33481703;33491328;34965436;8196765", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins (PubMed:18625724, PubMed:19194512, PubMed:20802492, PubMed:21902732, PubMed:31040179). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18 (PubMed:20802492). TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2 (PubMed:21931161, PubMed:24733891). Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death (PubMed:19194512)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXD2", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0034599 cellular response to oxidative stress;GO:0045019 negative regulation of nitric oxide biosynthetic process;GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P36152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36163-1", "uniprot_id": "OMA1_YEAST", "mass": 39328.0, "length": 345, "protein_name": "Mitochondrial metalloendopeptidase OMA1", "gene_name": "OMA1", "organism": "Yeast", "refseq_name": "metalloendopeptidase", "refseq_ac": "NP_013013", "gene_names_uniprotkb": "OMA1; YKR407", "gene_names_refseq": "OMA1", "protein_names_uniprotkb": "Mitochondrial metalloendopeptidase OMA1; 3.4.24.-", "protein_names_refseq": "metalloendopeptidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR087C); (R-SCE-169911); (R-SCE-9840373)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12748633;12963738;14562095;22219186;24374639;24648523;26365306;27325672;31044600;8196765;8203164", "class_list": "", "function": "Protease that is part of the quality control system in the inner membrane of mitochondria (PubMed:12963738, PubMed:22219186, PubMed:24648523, PubMed:27325672). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OXA1 and COX1 (PubMed:12963738, PubMed:22219186, PubMed:24648523). Cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins (PubMed:12963738, PubMed:27325672). Cleaves the misfolded multi-pass membrane protein OXA1 (PubMed:12963738). Involved in quality control of cytochrome oxidase assembly: mediates the cleavage of COX1 in cells lacking COA2 (PubMed:22219186). Required for the stability of the respiratory supercomplexes (PubMed:26365306). Required for TOR signaling (PubMed:27325672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE7", "ec_number_list": "3.4.24.-;3.6.5.5", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0031929 TOR signaling;GO:0035694 mitochondrial protein catabolic process;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0141164 mitochondrial protein quality control", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37299-1", "uniprot_id": "QCR10_YEAST", "mass": 8593.0, "length": 77, "protein_name": "Cytochrome b-c1 complex subunit 10, mitochondrial", "gene_name": "QCR10", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase subunit 10", "refseq_ac": "NP_011864", "gene_names_uniprotkb": "QCR10; YHR001BW", "gene_names_refseq": "QCR10", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 10, mitochondrial; Complex III subunit 10; Complex III subunit XI; Ubiquinol-cytochrome c oxidoreductase subunit 10; Ubiquinol-cytochrome c reductase 8.5 kDa protein", "protein_names_refseq": "ubiquinol--cytochrome-c reductase subunit 10", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR001W-A); (R-SCE-9865878)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10764779;10775262;1325905;14562106;24374639;30598554;30598556;8091229;8175712", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). QCR10 has a role in CIII assembly and RIP1 stability (PubMed:30598554, PubMed:30598556, PubMed:8175712)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKR8;O13538;Q9T2W2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P37299-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38816-1", "uniprot_id": "TRXB2_YEAST", "mass": 37087.0, "length": 342, "protein_name": "Thioredoxin reductase 2, mitochondrial", "gene_name": "TRR2", "organism": "Yeast", "refseq_name": "thioredoxin-disulfide reductase TRR2", "refseq_ac": "NP_011974", "gene_names_uniprotkb": "TRR2", "gene_names_refseq": "TRR2", "protein_names_uniprotkb": "Thioredoxin reductase 2, mitochondrial; 1.8.1.9", "protein_names_refseq": "thioredoxin-disulfide reductase TRR2", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR106W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10037727;14562106;16823961;17322287;24374639;8091229", "class_list": "", "function": "Acts on mitochondrial thioredoxin 3. Implicated in the defense against oxidative stress., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL56", "ec_number_list": "1.8.1.9", "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39007-1", "uniprot_id": "STT3_YEAST", "mass": 81529.0, "length": 718, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3", "gene_name": "STT3", "organism": "Yeast", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3", "refseq_ac": "NP_011493", "gene_names_uniprotkb": "STT3", "gene_names_refseq": "STT3", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3; 2.4.99.18; Oligosaccharyl transferase subunit STT3; Staurosporine and temperature sensitivity protein 3", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3", "tax_id": 559292, "disease": "congenital disorder of glycosylation Iw (Disease Ontology:DOID:0080572); congenital disorder of glycosylation Ix (Disease Ontology:DOID:0080573)", "pathway": " (sce:YGL022W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10677492;11580295;12359722;14562095;14562106;15507441;15781470;15831493;15886282;16096345;16096346;16297388;16847258;22865878;24374639;29301962;29466327;7588624;7590309;9169869;9405463;9435788", "class_list": "", "function": "Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:12359722). This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (PubMed:29301962)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VUB5", "ec_number_list": "2.4.99.18", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P39007-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39515-1", "uniprot_id": "TIM17_YEAST", "mass": 16584.0, "length": 158, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM17", "gene_name": "TIM17", "organism": "Yeast", "refseq_name": "protein transporter TIM17", "refseq_ac": "NP_012392", "gene_names_uniprotkb": "TIM17; J0648; MIM17; MPI2; SMS1", "gene_names_refseq": "MIM17; MPI2; SMS1; TIM17", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM17; Mitochondrial inner membrane protein MIM17; Mitochondrial protein import protein 2", "protein_names_refseq": "protein transporter TIM17", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL143W); (R-SCE-1268020)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562106;15618217;15797382;17322287;24374639;27265872;39753782;7919535;8050569;8050570;8641269;8813765", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW42;Q02310", "ec_number_list": "", "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P39515-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46673-1", "uniprot_id": "NUP85_YEAST", "mass": 84898.0, "length": 744, "protein_name": "Nucleoporin NUP85", "gene_name": "NUP85", "organism": "Yeast", "refseq_name": "Nup85p", "refseq_ac": "NP_012576", "gene_names_uniprotkb": "NUP85; J1624; RAT9", "gene_names_refseq": "NUP85; RAT9", "protein_names_uniprotkb": "Nucleoporin NUP85; Nuclear pore protein NUP85", "protein_names_refseq": "Nup85p", "tax_id": 559292, "disease": "nephrotic syndrome type 17 (Disease Ontology:DOID:0080392)", "pathway": " (sce:YJR042W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10684247;11071906;11823431;12543930;12730220;12791264;14562106;21126336;24374639;33491328;7668047;8565072;8641269;8816998;9774696", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWL3", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0045893 positive regulation of DNA-templated transcription;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P46673-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46984-1", "uniprot_id": "GON7_YEAST", "mass": 13605.0, "length": 123, "protein_name": "EKC/KEOPS complex subunit GON7", "gene_name": "GON7", "organism": "Yeast", "refseq_name": "chromatin DNA-binding EKC/KEOPS complex subunit GON7", "refseq_ac": "NP_012351", "gene_names_uniprotkb": "GON7; J0420; LDB6; PCC2", "gene_names_refseq": "GON7; LDB6; PCC2", "protein_names_uniprotkb": "EKC/KEOPS complex subunit GON7; Low-dye-binding protein 6; Polarized growth chromatin-associated controller 2", "protein_names_refseq": "chromatin DNA-binding EKC/KEOPS complex subunit GON7", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL184W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10681550;14562106;14690591;16564010;16874308;17322287;21183954;21459853;22814378;23258706;23620299;24374639;33481703;8641269", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW06", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000408 EKC/KEOPS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000723 telomere maintenance;GO:1990145 maintenance of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P46984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49687-1", "uniprot_id": "NU145_YEAST", "mass": 145661.0, "length": 1317, "protein_name": "Nucleoporin NUP145", "gene_name": "NUP145", "organism": "Yeast", "refseq_name": "nucleocytoplasmic transporter NUP145", "refseq_ac": "NP_011423", "gene_names_uniprotkb": "NUP145; RAT10", "gene_names_refseq": "NUP145; RAT10", "protein_names_uniprotkb": "Nucleoporin NUP145; 3.4.21.-; Nuclear pore protein NUP145", "protein_names_refseq": "nucleocytoplasmic transporter NUP145", "tax_id": 559292, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YGL092W)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "10542288;10638763;10684247;11823431;11875433;12604785;12791264;14562106;15039779;15665377;17287358;17330950;17563356;18160040;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8044840;8195299;8524308;9169869;9290212;9305650", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP145 is autocatalytically cleaved in vivo in 2 polypeptides which assume different functions in the NPC. NUP145N as one of the FG repeat nucleoporins participates in karyopherin interactions and contains part of the autocatalytic cleavage activity. NUP145C as part of the NUP84 complex is involved in nuclear poly(A)+ RNA and tRNA export. It is also required for normal NPC distribution (probably through interactions with MLP1 and MLP2) and NPC assembly, as well as for normal nuclear envelope organization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 34, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VU53", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044614 nuclear pore cytoplasmic filaments;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0031509 subtelomeric heterochromatin formation;GO:0006409 tRNA export from nucleus;GO:0046822 regulation of nucleocytoplasmic transport;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P49687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53112-1", "uniprot_id": "PEX14_YEAST", "mass": 38420.0, "length": 341, "protein_name": "Peroxisomal membrane protein PEX14", "gene_name": "PEX14", "organism": "Yeast", "refseq_name": "Pex14p", "refseq_ac": "NP_011362", "gene_names_uniprotkb": "PEX14; G1870", "gene_names_refseq": "PEX14", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX14; Peroxin-14", "protein_names_refseq": "Pex14p", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 13A (Disease Ontology:DOID:0080487)", "pathway": " (sce:YGL153W); (R-SCE-9033241); (R-SCE-9603798)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10087260;12453410;14562106;17322287;18407956;19779198;19795423;19823750;20154681;22814378;23749301;24374639;27678487;33042991;33323485;33481703;33491328;34965436;8585324;9094717;9169869;9425153", "class_list": "", "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor or the PEX7-PEX21 or PEX7-PEX18 receptor complex (PubMed:20154681, PubMed:9094717, PubMed:33323485). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (PubMed:20154681). Mechanistically, PEX5 (or PEX7-PEX21) receptor along with cargo proteins associates with the PEX14 and PEX17 subunits of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:20154681)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTZ8", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P53112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53323-1", "uniprot_id": "BUD32_YEAST", "mass": 29936.0, "length": 261, "protein_name": "EKC/KEOPS complex subunit BUD32", "gene_name": "BUD32", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase BUD32", "refseq_ac": "NP_011778", "gene_names_uniprotkb": "BUD32; LDB14", "gene_names_refseq": "BUD32; LDB14", "protein_names_uniprotkb": "EKC/KEOPS complex subunit BUD32; 2.7.11.1; 3.6.-.-; Atypical serine/threonine protein kinase BUD32; Bud site selection protein 32; Low-dye-binding protein 14; piD261", "protein_names_refseq": "serine/threonine protein kinase BUD32", "tax_id": 559292, "disease": "Galloway-Mowat syndrome 4 (Disease Ontology:DOID:0080246)", "pathway": " (sce:YGR262C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11452010;12023889;14562095;14562106;16564010;16874308;17322287;19021767;21183954;21459853;23258706;23620299;24374639;25735745;33491328;9090059;9169869", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Important for bud site selection., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV41", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;2.3.1.234;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000723 telomere maintenance;GO:1990145 maintenance of translational fidelity;GO:0002949 tRNA threonylcarbamoyladenosine modification", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53323-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00955-1", "uniprot_id": "ACAC_YEAST", "mass": 250353.0, "length": 2233, "protein_name": "Acetyl-CoA carboxylase", "gene_name": "ACC1", "organism": "Yeast", "refseq_name": "acetyl-CoA carboxylase ACC1", "refseq_ac": "NP_014413", "gene_names_uniprotkb": "ACC1; ABP2; FAS3; MTR7; N3175", "gene_names_refseq": "ABP2; ACC1; FAS3; MTR7", "protein_names_uniprotkb": "Acetyl-CoA carboxylase; 6.4.1.2; ACC; Fatty acid synthetase 3; mRNA transport-defective protein 7", "protein_names_refseq": "acetyl-CoA carboxylase ACC1", "tax_id": 559292, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YNR016C); (R-SCE-196780); (R-SCE-200425); (R-SCE-75105)", "pathway_count": 4, "publication_count": 43, "publication_id_list": "10757783;11875433;12663926;12730220;1350093;1359536;14562106;15079078;15610732;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24803522;24909858;26458104;27073141;27821475;27990296;29422886;30516470;32597660;33481703;33491328;6103540;6108218;7916271;8098706;8127678;8943372;9169873;9438137", "class_list": "", "function": "Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 58, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1J1", "ec_number_list": "2.7.11.1;6.3.4.14;6.4.1.2;6.3.4.-;6.3.4.10;6.3.4.11;6.3.4.15;6.3.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity", "go_cellular_component": "GO:0009317 acetyl-CoA carboxylase complex;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process;GO:0006085 acetyl-CoA biosynthetic process;GO:0042759 long-chain fatty acid biosynthetic process;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q00955-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02776-1", "uniprot_id": "TIM50_YEAST", "mass": 55099.0, "length": 476, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM50", "gene_name": "TIM50", "organism": "Yeast", "refseq_name": "protein translocase subunit TIM50", "refseq_ac": "NP_015262", "gene_names_uniprotkb": "TIM50", "gene_names_refseq": "TIM50", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM50", "protein_names_refseq": "protein translocase subunit TIM50", "tax_id": 559292, "disease": "3-methylglutaconic aciduria type 9 (Disease Ontology:DOID:0070002); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YPL063W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12437924;12437925;14532110;14562095;14562106;14690591;15797382;24374639;32597660;9169875", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex. Does not act as a structural subunit of the TIM23 complex but plays a dynamic role in protein import. Has no phosphatase activity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3V2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0046902 regulation of mitochondrial membrane permeability;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q02776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05568-1", "uniprot_id": "PEX10_YEAST", "mass": 39099.0, "length": 337, "protein_name": "Peroxisome biogenesis factor 10", "gene_name": "PEX10", "organism": "Yeast", "refseq_name": "ubiquitin-protein ligase peroxin 10", "refseq_ac": "NP_010551", "gene_names_uniprotkb": "PEX10; D9954.8; PAS4", "gene_names_refseq": "PAS4; PEX10", "protein_names_uniprotkb": "Peroxisome biogenesis factor 10; 2.3.2.27; Peroxin-10; Peroxisomal biogenesis factor 10; Peroxisome assembly protein 10", "protein_names_refseq": "ubiquitin-protein ligase peroxin 10", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 6A (Disease Ontology:DOID:0080481); Peroxisome biogenesis disorder 6B (Disease Ontology:DOID:0081435); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (sce:YDR265W); (R-SCE-9033241)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12876220;15283676;17322287;18644345;19687296;22471590;22814378;24374639;27678487;33491328;35768507;9169867", "class_list": "", "function": "E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:18644345, PubMed:19687296, PubMed:22471590, PubMed:35768507). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:15283676, PubMed:18644345, PubMed:35768507). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (PubMed:35768507)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSP9;E9P8T2", "ec_number_list": "1.11.1.6;2.3.2.23;1.6.2.4;1.1.1.42;2.3.1.16;1.3.1.124;2.3.1.7;4.1.2.63;3.1.2.2;2.3.2.27;5.3.3.8;3.4.24.-;3.6.1.-;3.6.1.56;3.6.1.77", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0016558 protein import into peroxisome matrix", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05568-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38777-1", "uniprot_id": "FSH1_YEAST", "mass": 27339.0, "length": 243, "protein_name": "Family of serine hydrolases 1", "gene_name": "FSH1", "organism": "Yeast", "refseq_name": "putative serine hydrolase", "refseq_ac": "NP_011915", "gene_names_uniprotkb": "FSH1", "gene_names_refseq": "FSH1", "protein_names_uniprotkb": "Family of serine hydrolases 1; 3.1.-.-", "protein_names_refseq": "putative serine hydrolase", "tax_id": 559292, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (sce:YHR049W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14645503;15802654;17322287;24374639;33481703;33491328;8091229", "class_list": "", "function": "Serine hydrolase of unknown specificity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKZ7", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0016788 hydrolase activity, acting on ester bonds;GO:0004622 phosphatidylcholine lysophospholipase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38777-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38790-1", "uniprot_id": "HTD2_YEAST", "mass": 33055.0, "length": 280, "protein_name": "Hydroxyacyl-thioester dehydratase type 2, mitochondrial", "gene_name": "HTD2", "organism": "Yeast", "refseq_name": "hydroxyacyl-thioester dehydratase HTD2", "refseq_ac": "NP_011934", "gene_names_uniprotkb": "HTD2; RMD12", "gene_names_refseq": "HTD2; RMD12", "protein_names_uniprotkb": "Hydroxyacyl-thioester dehydratase type 2, mitochondrial; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 4.2.1.-", "protein_names_refseq": "hydroxyacyl-thioester dehydratase HTD2", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR067W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;15387819;16823961;24374639;8091229", "class_list": "", "function": "Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis. Required for respiratory growth and for normal mitochondrial morphology., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL16", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38790-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39724-1", "uniprot_id": "BOL3_YEAST", "mass": 13356.0, "length": 118, "protein_name": "BolA-like protein 3", "gene_name": "BOL3", "organism": "Yeast", "refseq_name": "Bol3p", "refseq_ac": "NP_009353", "gene_names_uniprotkb": "BOL3; AIM1", "gene_names_refseq": "AIM1; BOL3", "protein_names_uniprotkb": "BolA-like protein 3; Altered inheritance of mitochondria protein 1", "protein_names_refseq": "Bol3p", "tax_id": 559292, "disease": "multiple mitochondrial dysfunctions syndrome 2 (Disease Ontology:DOID:0080134)", "pathway": " (sce:YAL046C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;19300474;24374639;27532772;27532773;7731988", "class_list": "", "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates [4Fe-4S] cluster insertion into a subset of mitochondrial proteins such as lipoyl synthase (LS) and succinate dehydrogenase (SDH) (PubMed:27532772, PubMed:27532773). Required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532772). Acts together with NFU1, later than BOL1 and GRX5 in the [4Fe-4S] cluster insertion process (PubMed:27532773). Not required for [2Fe-2S] cluster insertion into mitochondrial proteins (PubMed:27532772)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P39724-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40351-1", "uniprot_id": "ALG8_YEAST", "mass": 67385.0, "length": 577, "protein_name": "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase", "gene_name": "ALG8", "organism": "Yeast", "refseq_name": "dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase", "refseq_ac": "NP_014710", "gene_names_uniprotkb": "ALG8; YOR29-18", "gene_names_refseq": "ALG8; YOR29-18", "protein_names_uniprotkb": "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; 2.4.1.265; Asparagine-linked glycosylation protein 8; Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase", "protein_names_refseq": "dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); polycystic liver disease 3 (Disease Ontology:DOID:0060976); congenital disorder of glycosylation Ih (Disease Ontology:DOID:0080560)", "pathway": " (sce:YOR067C); (R-SCE-446193)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16847258;24374639;3536907;8016100;9133743;9169874", "class_list": "", "function": "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol. Glc(2)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG10, the following enzyme in the biosynthetic pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2D0", "ec_number_list": "2.4.1.265", "go_molecular_function": "GO:0042283 dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41734-1", "uniprot_id": "IAH1_YEAST", "mass": 27346.0, "length": 238, "protein_name": "Isoamyl acetate-hydrolyzing esterase", "gene_name": "IAH1", "organism": "Yeast", "refseq_name": "isoamyl acetate-hydrolyzing esterase", "refseq_ac": "NP_014769", "gene_names_uniprotkb": "IAH1; EST2; O3287; YOR3287C", "gene_names_refseq": "IAH1", "protein_names_uniprotkb": "Isoamyl acetate-hydrolyzing esterase; 3.1.1.112", "protein_names_refseq": "isoamyl acetate-hydrolyzing esterase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR126C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10855721;17322287;21069734;24374639;8904341;9169874;9200815", "class_list": "", "function": "Plays a crucial role in the hydrolysis of isoamyl acetate in sake mash (Ref.2). Hydrolyzes short chain esters from acetate (C2) to hexanoate (C6), showing more specificity for shorter chain exters. No activity for decanoate (C10) esters (PubMed:21069734)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2I4;Q92313", "ec_number_list": "3.1.1.112", "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "", "go_biological_process": "GO:0006083 acetate metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P41734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47163-1", "uniprot_id": "EFM3_YEAST", "mass": 39024.0, "length": 339, "protein_name": "Protein-lysine N-methyltransferase EFM3", "gene_name": "EFM3", "organism": "Yeast", "refseq_name": "protein-lysine N-methyltransferase", "refseq_ac": "NP_012663", "gene_names_uniprotkb": "EFM3; J2061", "gene_names_refseq": "EFM3", "protein_names_uniprotkb": "Protein-lysine N-methyltransferase EFM3; 2.1.1.-; Elongation factor methyltransferase 3", "protein_names_refseq": "protein-lysine N-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR129C); (R-SCE-8876725)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;14562106;18407956;22814378;24374639;25086354;25231979;25231983;8641269", "class_list": "", "function": "S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono-, di- and trimethylates elongation factor 2 (EFT1/EFT2) at 'Lys-509'., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWU7", "ec_number_list": "3.6.5.-;2.1.1.-", "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0018023 peptidyl-lysine trimethylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53600-1", "uniprot_id": "COPZ_YEAST", "mass": 21688.0, "length": 189, "protein_name": "Coatomer subunit zeta", "gene_name": "RET3", "organism": "Yeast", "refseq_name": "coatomer subunit zeta", "refseq_ac": "NP_015315", "gene_names_uniprotkb": "RET3; LPA7W; YP8132.03", "gene_names_refseq": "RET3", "protein_names_uniprotkb": "Coatomer subunit zeta; Zeta-COP; Zeta-coat protein", "protein_names_refseq": "coatomer subunit zeta", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL010W); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17322287;24374639;8617224;9058184;9169875", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (PubMed:9058184). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (PubMed:9058184)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W402", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53600-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05506-1", "uniprot_id": "SYRC_YEAST", "mass": 69525.0, "length": 607, "protein_name": "Arginine--tRNA ligase, cytoplasmic", "gene_name": "D9651.10", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "D9651.10", "gene_names_refseq": "", "protein_names_uniprotkb": "Arginine--tRNA ligase, cytoplasmic; 6.1.1.19; ArgRS; Arginyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 6 (Disease Ontology:DOID:0060275)", "pathway": " (sce:YDR341C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11060012;14562106;17330950;17563356;18407956;19779198;19795423;19823750;22814378;23749301;24374639;32597660;33481703;33491328;9169867;9736621", "class_list": "", "function": "Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSX2", "ec_number_list": "6.1.1.19", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0005524 ATP binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q05506-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08726-1", "uniprot_id": "GPN2_YEAST", "mass": 39724.0, "length": 347, "protein_name": "GPN-loop GTPase 2", "gene_name": "GPN2", "organism": "Yeast", "refseq_name": "GTPase GPN2", "refseq_ac": "NP_014905", "gene_names_uniprotkb": "GPN2", "gene_names_refseq": "GPN2", "protein_names_uniprotkb": "GPN-loop GTPase 2; 3.6.5.-; ATP-binding domain 1 family member B homolog", "protein_names_refseq": "GTPase GPN2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR262W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14690591;18439903;21532343;21844196;23267056;23324351;24374639;9153759;9169874", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase RNA polymerase II and III (RNAPII and RNAPIII) complexes, ensuring their proper nuclear import (PubMed:23267056). Required for establishment of sister chromatid cohesion (PubMed:18439903)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2W3", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08726-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E731-1", "uniprot_id": "COX19_YEAST", "mass": 11105.0, "length": 98, "protein_name": "Cytochrome c oxidase assembly protein COX19", "gene_name": "COX19", "organism": "Yeast", "refseq_name": "Cox19p", "refseq_ac": "NP_013082", "gene_names_uniprotkb": "COX19", "gene_names_refseq": "COX19", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX19", "protein_names_refseq": "Cox19p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL018C-A)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12171940;14562095;14562106;22984289;24374639;25926683;9169871", "class_list": "", "function": "Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:12171940, PubMed:25926683). Acts as a COX11 chaperone that supports COX11 copper coordination (PubMed:25926683). Cannot compensate for the absence of COX11 (PubMed:25926683)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXY5", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0051604 protein maturation;GO:0030001 metal ion transport;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3E731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E785-1", "uniprot_id": "SDHF1_YEAST", "mass": 9352.0, "length": 79, "protein_name": "Succinate dehydrogenase assembly factor 1, mitochondrial", "gene_name": "SDH6", "organism": "Yeast", "refseq_name": "Sdh6p", "refseq_ac": "NP_076888", "gene_names_uniprotkb": "SDH6; smORF139; smORF8", "gene_names_refseq": "SDH6", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 1, mitochondrial; SDH assembly factor 1; SDHAF1", "protein_names_refseq": "Sdh6p", "tax_id": 559292, "disease": "mitochondrial complex II deficiency (Disease Ontology:DOID:0060537)", "pathway": " (sce:YDR379C-A)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11152879;12566404;14562095;14562106;19465911;24374639;24954417;9169867", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDH2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. Acts together with SDHAF3 (SDH7)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT12", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0034553 mitochondrial respiratory chain complex II assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3E785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14284-1", "uniprot_id": "DPOZ_YEAST", "mass": 172957.0, "length": 1504, "protein_name": "DNA polymerase zeta catalytic subunit", "gene_name": "REV3", "organism": "Yeast", "refseq_name": "DNA-directed DNA polymerase", "refseq_ac": "NP_015158", "gene_names_uniprotkb": "REV3; P2535; PSO1", "gene_names_refseq": "PSO1; REV3", "protein_names_uniprotkb": "DNA polymerase zeta catalytic subunit; 2.7.7.7; Protein reversionless 3", "protein_names_refseq": "DNA-directed DNA polymerase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL167C); (R-SCE-110312)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10931348;11316789;16452144;20388628;22119860;24049079;24374639;2676986;33491328;8658138;8948103;9169875", "class_list": "", "function": "Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS) (PubMed:2676986, PubMed:8658138, PubMed:11316789). Has a role in the bypass of abasic sites and T-T (6-4) UV photoproducts; this process is dependent on the REV1 non-catalytic activity (PubMed:10931348, PubMed:11316789). Highly inefficient in incorporating nucleotides opposite the AP site, but efficiently extends from nucleotides, particularly an A, inserted opposite the lesion (PubMed:11316789). Together with deoxycytidyl transferase REV1, involved in translesion synthesis of the 1,N6-ethenoadenine DNA adduct; the deoxycytidyl transferase catalyzes insertion of cytosine opposite the lesion, followed by extension synthesis by DNA polymerase zeta (PubMed:20388628). REV1 and DNA polymerase zeta are similarly activated when replication forks are stalled at non-canonical hairpin DNA structures; REV1 incorporates a cytosine across from the base of the structure, which triggers a template-switching event that allows for hairpin bypass, but is highly mutagenic due to the use of an ectopic DNA template and the involvement of the low-fidelity DNA polymerase zeta (PubMed:24049079). Not required for the bypass of T-T cyclobutane dimers (PubMed:10931348). Also functions in the mitochondrion (PubMed:16452144)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3K1", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis;GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P14284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14742-1", "uniprot_id": "GFA1_YEAST", "mass": 80047.0, "length": 717, "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing]", "gene_name": "GFA1", "organism": "Yeast", "refseq_name": "glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1", "refseq_ac": "NP_012818", "gene_names_uniprotkb": "GFA1; YKL457", "gene_names_refseq": "GFA1", "protein_names_uniprotkb": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; 2.6.1.16; D-fructose-6-phosphate amidotransferase; GFAT; Hexosephosphate aminotransferase", "protein_names_refseq": "glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1", "tax_id": 559292, "disease": "congenital myasthenic syndrome 12 (Disease Ontology:DOID:0110660); familial hyperlipidemia (Disease Ontology:DOID:1168); Machado-Joseph disease (Disease Ontology:DOID:1440); hyperinsulinism (Disease Ontology:DOID:2018); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YKL104C); (R-SCE-446210)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "14562106;15665377;15699032;17563356;18407956;19684113;19779198;20702584;21126336;21177495;22218487;23749301;24374639;2656689;32597660;33481703;33491328;8109175;8196765", "class_list": "", "function": "Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXI4", "ec_number_list": "2.6.1.16", "go_molecular_function": "GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006047 UDP-N-acetylglucosamine metabolic process;GO:0006002 fructose 6-phosphate metabolic process;GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P14742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14907-1", "uniprot_id": "NSP1_YEAST", "mass": 86516.0, "length": 823, "protein_name": "Nucleoporin NSP1", "gene_name": "NSP1", "organism": "Yeast", "refseq_name": "FG-nucleoporin NSP1", "refseq_ac": "NP_012494", "gene_names_uniprotkb": "NSP1; J1207", "gene_names_refseq": "NSP1", "protein_names_uniprotkb": "Nucleoporin NSP1; Nuclear pore protein NSP1; Nucleoskeletal-like protein; p110", "protein_names_refseq": "FG-nucleoporin NSP1", "tax_id": 559292, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); striatonigral degeneration (Disease Ontology:DOID:4751)", "pathway": " (sce:YJL041W)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10684247;10889207;10952996;11352936;11387327;11689687;11739405;12372823;12604785;12791264;14562106;15039779;17563356;18407956;19779198;2112428;21126336;21177495;22218487;23749301;24374639;25646085;3072197;32597660;33229814;33481703;33491328;8641269;9017593;9461539;9774653;9843582;9891088", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NSP1 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, pre-ribosome, signal recognition particle (SRP), and protein transport., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6VWE3", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0034399 nuclear periphery", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:0006409 tRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P14907-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15303-1", "uniprot_id": "SEC23_YEAST", "mass": 85385.0, "length": 768, "protein_name": "Protein transport protein SEC23", "gene_name": "SEC23", "organism": "Yeast", "refseq_name": "GTPase-activating protein SEC23", "refseq_ac": "NP_015507", "gene_names_uniprotkb": "SEC23; P9705.14", "gene_names_refseq": "SEC23", "protein_names_uniprotkb": "Protein transport protein SEC23", "protein_names_refseq": "GTPase-activating protein SEC23", "tax_id": 559292, "disease": "craniolenticulosutural dysplasia (Disease Ontology:DOID:0070307); Cowden syndrome 7 (Disease Ontology:DOID:0081003); congenital dyserythropoietic anemia type II (Disease Ontology:DOID:0111401); Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": " (sce:YPR181C); (R-SCE-204005); (R-SCE-5694530); (R-SCE-983170)", "pathway_count": 4, "publication_count": 47, "publication_id_list": "10198022;10564255;10712514;10720463;11086000;11389436;11535824;11560939;11717432;11726510;12235121;12239560;12671686;12778054;12941276;14627716;1498369;16269340;17261844;17287728;18407956;19779198;21532587;2188733;22814378;24374639;2670558;3049622;3293799;33481703;33491328;6996832;7026045;7593161;7925484;8451644;8548805;8909535;8930902;9023343;9169875;9325247;9427388;9428766;9568718;9624457;9685263", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC23 interacts with BET3 in order to target TRAPPI complex to COPII involved in internalization of plasma membrane proteins like the maltose transporter., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4I1", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0070863 positive regulation of protein exit from endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P15303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15436-1", "uniprot_id": "DPOD_YEAST", "mass": 124619.0, "length": 1097, "protein_name": "DNA polymerase delta catalytic subunit", "gene_name": "POL3", "organism": "Yeast", "refseq_name": "DNA-directed DNA polymerase delta POL3", "refseq_ac": "NP_010181", "gene_names_uniprotkb": "POL3; CDC2; D2366; TEX1", "gene_names_refseq": "CDC2; HPR6; POL3; TEX1", "protein_names_uniprotkb": "DNA polymerase delta catalytic subunit; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-; DNA polymerase III", "protein_names_refseq": "DNA-directed DNA polymerase delta POL3", "tax_id": 559292, "disease": "immunodeficiency 120 (Disease Ontology:DOID:0061086); endometrial cancer (Disease Ontology:DOID:1380); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YDL102W); (R-SCE-69166); (R-SCE-69183)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "11568188;14562095;1648480;17287358;17330950;1741270;17563356;18407956;19779198;22119860;23749301;24374639;2670563;31488849;32597660;33481703;33491328;8896274;9169867", "class_list": "", "function": "Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication (PubMed:22119860, PubMed:2670563, PubMed:31488849). Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (PubMed:31488849). Participates in leading strand synthesis during replication initiation and termination (PubMed:31488849). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (PubMed:1648480)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRP8", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;5.6.2.3;2.7.7.-;3.1.11.-;3.1.-.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008296 3'-5'-DNA exonuclease activity;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005829 cytosol;GO:0005657 replication fork", "go_biological_process": "GO:0006278 RNA-templated DNA biosynthetic process;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P15436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15442-1", "uniprot_id": "GCN2_YEAST", "mass": 190193.0, "length": 1659, "protein_name": "eIF-2-alpha kinase GCN2", "gene_name": "GCN2", "organism": "Yeast", "refseq_name": "serine/threonine-protein kinase GCN2", "refseq_ac": "NP_010569", "gene_names_uniprotkb": "GCN2; AAS1", "gene_names_refseq": "AAS102; AAS1; GCN2; NDR2", "protein_names_uniprotkb": "eIF-2-alpha kinase GCN2; 2.7.11.1; General control non-derepressible protein 2; Serine/threonine-protein kinase GCN2", "protein_names_refseq": "serine/threonine-protein kinase GCN2", "tax_id": 559292, "disease": "pulmonary venoocclusive disease 2 (Disease Ontology:DOID:0081269); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YDR283C)", "pathway_count": 1, "publication_count": 48, "publication_id_list": "10733573;10775272;10801780;10983975;11101534;11250908;11350982;12070158;12654728;1448107;14562106;15665377;15964839;17202131;17287358;1739968;18407956;19114556;19779198;20077113;2038314;20404097;20489023;20702584;21126336;21177495;21849502;2188100;22218487;22888004;23749301;24333428;24374639;2660141;32597660;3290651;33338396;33481703;33491328;34965436;7621831;7623840;8336737;8798780;9169867;9430731;9528799;9566889", "class_list": "", "function": "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52' in response to low amino acid, carbon, or purine availability (PubMed:10733573, PubMed:10983975, PubMed:17202131, PubMed:1739968, PubMed:33338396, PubMed:7623840, PubMed:8336737, PubMed:8798780, PubMed:9528799). Required for adapatation to nutrient starvation by acting as a key component of the integrated stress response (ISR), by which cells alter their translational and transcriptional output in response to starvation (PubMed:10733573, PubMed:10983975, PubMed:17202131, PubMed:1739968, PubMed:33338396, PubMed:7623840, PubMed:8336737, PubMed:8798780, PubMed:9528799). Converts phosphorylated eIF-2-alpha/SUI2 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator GCN4, and hence allowing GCN4-mediated reprogramming of transcription to alleviate nutrient depletion (PubMed:10733573, PubMed:10801780, PubMed:11350982, PubMed:1739968, PubMed:2188100, PubMed:24333428, PubMed:2660141, PubMed:33338396, PubMed:7621831, PubMed:7623840, PubMed:8798780). Binds uncharged tRNAs (PubMed:10983975, PubMed:7623840). Binds to aminoacylated tRNA(Phe) less tightly than to deacylated tRNA(Phe) (PubMed:10983975). Binds to double-stranded RNA (PubMed:9430731)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 40, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSR3", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;3.6.5.3;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0015935 small ribosomal subunit", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0046777 protein autophosphorylation;GO:0006412 translation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P15442-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15625-1", "uniprot_id": "SYFA_YEAST", "mass": 57511.0, "length": 503, "protein_name": "Phenylalanine--tRNA ligase alpha subunit", "gene_name": "FRS2", "organism": "Yeast", "refseq_name": "phenylalanine--tRNA ligase subunit alpha", "refseq_ac": "NP_116631", "gene_names_uniprotkb": "FRS2", "gene_names_refseq": "FRS2", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase alpha subunit; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase alpha subunit", "protein_names_refseq": "phenylalanine--tRNA ligase subunit alpha", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL022C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18407956;19779198;21126336;23749301;24374639;2644133;3049607;33481703;33491328;7670463;9298649", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTK8", "ec_number_list": "6.1.1.20", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004826 phenylalanine-tRNA ligase activity", "go_cellular_component": "GO:0009328 phenylalanine-tRNA ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006432 phenylalanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P15625-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15646-1", "uniprot_id": "FBRL_YEAST", "mass": 34465.0, "length": 327, "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "NOP1", "organism": "Yeast", "refseq_name": "rRNA methyltransferase NOP1", "refseq_ac": "NP_010270", "gene_names_uniprotkb": "NOP1; D2870; LOT3", "gene_names_refseq": "LOT3; NOP1", "protein_names_uniprotkb": "rRNA 2'-O-methyltransferase fibrillarin; 2.1.1.-; Histone-glutamine methyltransferase; Nucleolar protein 1; U3 small nucleolar RNA-associated protein NOP1; U3 snoRNA-associated protein NOP1", "protein_names_refseq": "rRNA methyltransferase NOP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL014W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "12068309;12215523;12756332;17563356;1825809;22106047;2298745;23865587;24352239;24374639;26046779;26081071;2686980;28244370;28945246;31756331;32597660;32943521;32943522;33326748;33481703;33483369;33491328;33856219;8508778;9169867;9372940", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:12215523, PubMed:1825809, PubMed:2686980). Site specificity is provided by a guide RNA that base pairs with the substrate (PubMed:1825809, PubMed:2686980). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (PubMed:1825809, PubMed:2686980). Involved in the biogenesis of the 18S rRNA (PubMed:1825809, PubMed:2686980). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRX5;P89890", "ec_number_list": "2.1.1.-;2.7.11.1;3.6.4.13;2.1.1.260;3.6.5.-;3.1.13.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0008171 O-methyltransferase activity;GO:0008649 rRNA methyltransferase activity;GO:1990259 histone H2AQ104 methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031428 box C/D methylation guide snoRNP complex;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006364 rRNA processing;GO:0000494 box C/D sno(s)RNA 3'-end processing;GO:0030490 maturation of SSU-rRNA;GO:0006356 regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P15646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16664-1", "uniprot_id": "RGP1_YEAST", "mass": 75317.0, "length": 663, "protein_name": "Guanine nucleotide exchange factor subunit RGP1", "gene_name": "RGP1", "organism": "Yeast", "refseq_name": "Rgp1p", "refseq_ac": "NP_010421", "gene_names_uniprotkb": "RGP1; YD9302.13", "gene_names_refseq": "RGP1", "protein_names_uniprotkb": "Guanine nucleotide exchange factor subunit RGP1; Reduced growth phenotype protein 1; Rgp1p", "protein_names_refseq": "Rgp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR137W); (R-SCE-6811440); (R-SCE-8876198)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10990452;11689439;14562106;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;2179863;23749301;24374639;30516470;32597660;33481703;33491328;9169867", "class_list": "", "function": "Required for proper mitotic growth., [UniProtKB]; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSC0;Q03915", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0051301 cell division;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P16664-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21951-1", "uniprot_id": "DPOE_YEAST", "mass": 255671.0, "length": 2222, "protein_name": "DNA polymerase epsilon catalytic subunit A", "gene_name": "POL2", "organism": "Yeast", "refseq_name": "DNA polymerase epsilon catalytic subunit", "refseq_ac": "NP_014137", "gene_names_uniprotkb": "POL2; DUN2; N0825", "gene_names_refseq": "DUN2; POL2", "protein_names_uniprotkb": "DNA polymerase epsilon catalytic subunit A; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-; DNA polymerase II subunit A", "protein_names_refseq": "DNA polymerase epsilon catalytic subunit", "tax_id": 559292, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); duodenum cancer (Disease Ontology:DOID:10021); prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); cancer (Disease Ontology:DOID:162); ascending colon cancer (Disease Ontology:DOID:218); ovarian cancer (Disease Ontology:DOID:2394); kidney cancer (Disease Ontology:DOID:263); endometrial carcinoma (Disease Ontology:DOID:2871); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); anaplastic astrocytoma (Disease Ontology:DOID:3078); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); endometrial serous adenocarcinoma (Disease Ontology:DOID:5750); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YNL262W); (R-SCE-6782135); (R-SCE-68952); (R-SCE-68962)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "11024162;12124389;12571237;14562106;1537345;17563356;19779198;21126336;2169349;22119860;24374639;31488849;32597660;33491328;8740425;9169873", "class_list": "", "function": "Catalytic component of the DNA polymerase epsilon complex which participates in chromosomal DNA replication (PubMed:1537345). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (PubMed:31488849). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (PubMed:12124389)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0T1", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;2.7.11.22;2.7.7.6;2.7.11.23;2.7.11.1;5.6.2.3;3.1.-.-;2.7.7.-;3.1.11.-;3.6.4.12;2.3.2.27;3.6.4.-;3.4.19.12;5.2.1.8;5.6.2.4", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005657 replication fork", "go_biological_process": "GO:0035822 gene conversion;GO:0006272 leading strand elongation;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P21951-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22289-1", "uniprot_id": "QCR9_YEAST", "mass": 7476.0, "length": 66, "protein_name": "Cytochrome b-c1 complex subunit 9, mitochondrial", "gene_name": "QCR9", "organism": "Yeast", "refseq_name": "ubiquinol--cytochrome-c reductase subunit 9", "refseq_ac": "NP_011699", "gene_names_uniprotkb": "QCR9; UCR9", "gene_names_refseq": "QCR9; UCR9", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 9, mitochondrial; Complex III subunit 9; Complex III subunit X; Cytochrome c1 non-heme 7.3 kDa protein; Ubiquinol-cytochrome c oxidoreductase subunit 9; Ubiquinol-cytochrome c reductase 7.3 kDa protein", "protein_names_refseq": "ubiquinol--cytochrome-c reductase subunit 9", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR183C); (R-SCE-611105); (R-SCE-9865878)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10764779;10775262;10873857;11880631;14562106;18390544;2174427;24374639;30598554;30598556;9133739;9169869", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0009060 aerobic respiration;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P22289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22515-1", "uniprot_id": "UBA1_YEAST", "mass": 114266.0, "length": 1024, "protein_name": "Ubiquitin-activating enzyme E1 1", "gene_name": "UBA1", "organism": "Yeast", "refseq_name": "E1 ubiquitin-activating protein UBA1", "refseq_ac": "NP_012712", "gene_names_uniprotkb": "UBA1", "gene_names_refseq": "UBA1", "protein_names_uniprotkb": "Ubiquitin-activating enzyme E1 1; 6.2.1.45", "protein_names_refseq": "E1 ubiquitin-activating protein UBA1", "tax_id": 559292, "disease": "VEXAS syndrome (Disease Ontology:DOID:0080828); X-linked spinal muscular atrophy 2 (Disease Ontology:DOID:0111827)", "pathway": " (sce:YKL210W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;17287358;18407956;18662542;19779198;1989885;19920177;22106047;22814378;24374639;24816100;2569166;30516470;33481703;33491328;35970836;8196765", "class_list": "", "function": "E1 ubiquitin-activating enzyme that catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (By similarity). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:18662542, PubMed:1989885, PubMed:24816100, PubMed:35970836). The RSP5-UBA1-UBC5 ubiquitin ligase complex ubiquitinates RPO21 forming 'Lys-63'-linked polyubiquitin chains (PubMed:19920177)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ3", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004839 ubiquitin activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P22515-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23254-1", "uniprot_id": "TKT1_YEAST", "mass": 73806.0, "length": 680, "protein_name": "Transketolase 1", "gene_name": "TKL1", "organism": "Yeast", "refseq_name": "transketolase TKL1", "refseq_ac": "NP_015399", "gene_names_uniprotkb": "TKL1; YP9499.29C", "gene_names_refseq": "TKL1", "protein_names_uniprotkb": "Transketolase 1; 2.2.1.1; TK 1", "protein_names_refseq": "transketolase TKL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR074C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11773632;14562106;15665377;1628611;17287358;17330950;1737042;1812485;18186462;18407956;19779198;20702584;22106047;22814378;23749301;24374639;30516470;32597660;33481703;33491328;8144674;8176731;8226984;8521838;8999873;9119035;9169875;9398292", "class_list": "", "function": "Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (PubMed:8521838). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (PubMed:8521838)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W478", "ec_number_list": "2.2.1.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004802 transketolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006098 pentose-phosphate shunt", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P23254-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23644-1", "uniprot_id": "TOM40_YEAST", "mass": 42038.0, "length": 387, "protein_name": "Mitochondrial import receptor subunit TOM40", "gene_name": "TOM40", "organism": "Yeast", "refseq_name": "TOM complex pore protein TOM40", "refseq_ac": "NP_013930", "gene_names_uniprotkb": "TOM40; ISP42; MOM38; YM8325.04", "gene_names_refseq": "ISP42; MOM38; TOM40", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40; Mitochondrial import site protein ISP42; Translocase of outer membrane 40 kDa subunit", "protein_names_refseq": "TOM complex pore protein TOM40", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (sce:YMR203W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10427088;14690591;17322287;21215441;21944719;2250717;24374639;9169872;9774667", "class_list": "", "function": "Channel-forming protein essential for import of protein precursors into mitochondria., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W028;Q6B1Q9", "ec_number_list": "", "go_molecular_function": "GO:0015288 porin activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0046930 pore complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0006811 monoatomic ion transport;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23644-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24309-1", "uniprot_id": "DBR1_YEAST", "mass": 47741.0, "length": 405, "protein_name": "Lariat debranching enzyme", "gene_name": "DBR1", "organism": "Yeast", "refseq_name": "RNA lariat debranching enzyme", "refseq_ac": "NP_012773", "gene_names_uniprotkb": "DBR1; PRP26; YKL604", "gene_names_refseq": "DBR1; PRP26", "protein_names_uniprotkb": "Lariat debranching enzyme; 3.1.4.-", "protein_names_refseq": "RNA lariat debranching enzyme", "tax_id": 559292, "disease": "brain disease (Disease Ontology:DOID:936)", "pathway": " (sce:YKL149C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14716018;1518827;17330950;1850323;19779198;23749301;24374639;33481703;33491328;35459748;8091859;8196765", "class_list": "", "function": "Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:35459748). It also participates in Ty1 retrovirus-like transposition via an RNA lariat intermediate in cDNA synthesis (PubMed:14716018)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX48", "ec_number_list": "", "go_molecular_function": "GO:0008419 RNA lariat debranching enzyme activity;GO:0003723 RNA binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016074 sno(s)RNA metabolic process;GO:0000375 RNA splicing, via transesterification reactions;GO:0032197 retrotransposition;GO:0000398 mRNA splicing, via spliceosome;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P24309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24384-1", "uniprot_id": "PRP22_YEAST", "mass": 130011.0, "length": 1145, "protein_name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22", "gene_name": "PRP22", "organism": "Yeast", "refseq_name": "DEAH-box ATP-dependent RNA helicase PRP22", "refseq_ac": "NP_010929", "gene_names_uniprotkb": "PRP22", "gene_names_refseq": "PRP22", "protein_names_uniprotkb": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22; 3.6.4.13", "protein_names_refseq": "DEAH-box ATP-dependent RNA helicase PRP22", "tax_id": 559292, "disease": "", "pathway": " (sce:YER013W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11884590;14562106;15665377;17330950;18407956;19779198;1992352;20702584;23096351;23749301;24374639;32597660;33481703;33491328;9169868", "class_list": "", "function": "Acts late in the splicing of pre-mRNA. Mediates the release of the spliced mRNA from spliceosomes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR0", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0071021 U2-type post-spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P24384-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24482-1", "uniprot_id": "DPB2_YEAST", "mass": 78340.0, "length": 689, "protein_name": "DNA polymerase epsilon subunit B", "gene_name": "DPB2", "organism": "Yeast", "refseq_name": "DNA polymerase epsilon noncatalytic subunit", "refseq_ac": "NP_015501", "gene_names_uniprotkb": "DPB2; P9705.7", "gene_names_refseq": "DPB2", "protein_names_uniprotkb": "DNA polymerase epsilon subunit B; DNA polymerase II subunit 2", "protein_names_refseq": "DNA polymerase epsilon noncatalytic subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR175W); (R-SCE-6782135); (R-SCE-68952); (R-SCE-68962)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "11024162;12124389;12571237;12748633;14562095;14562106;14747467;19779198;2052544;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "As accessory component of the DNA polymerase epsilon complex participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4H6;Q06622", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042276 error-prone translesion synthesis;GO:0006261 DNA-templated DNA replication;GO:0045005 DNA-templated DNA replication maintenance of fidelity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P24482-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25382-1", "uniprot_id": "NLE1_YEAST", "mass": 57026.0, "length": 515, "protein_name": "Ribosome assembly protein 4", "gene_name": "RSA4", "organism": "Yeast", "refseq_name": "Rsa4p", "refseq_ac": "NP_009997", "gene_names_uniprotkb": "RSA4; YCR72C", "gene_names_refseq": "RSA4", "protein_names_uniprotkb": "Ribosome assembly protein 4; Notchless protein homolog 1; Ribosome biogenesis factor RSA4", "protein_names_refseq": "Rsa4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR072C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "1574125;16221974;16702403;17322287;17330950;18407956;18658244;19737519;20542003;24374639;24662372;25404745;26619264;27251291;33491328", "class_list": "", "function": "Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin (MDN1/REA1), which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR74;Q8NKJ4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000027 ribosomal large subunit assembly;GO:0110136 protein-RNA complex remodeling", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P25382-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25554-1", "uniprot_id": "SGF29_YEAST", "mass": 29381.0, "length": 259, "protein_name": "SAGA complex subunit SGF29", "gene_name": "SGF29", "organism": "Yeast", "refseq_name": "Sgf29p", "refseq_ac": "NP_009917", "gene_names_uniprotkb": "SGF29; YCL10C", "gene_names_refseq": "SGF29", "protein_names_uniprotkb": "SAGA complex subunit SGF29; 29 kDa SAGA-associated factor; SAGA histone acetyltransferase complex 29 kDa subunit; SAGA-associated factor 29", "protein_names_refseq": "Sgf29p", "tax_id": 559292, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (sce:YCL010C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10026213;10864329;12052880;14562106;15260971;15647753;15665377;1574125;17330950;18407956;19779198;21685874;21734642;22224423;23749301;24307402;24374639;25216679;28918903;32597660;33481703;33491328;33864814", "class_list": "", "function": "Chromatin reader component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10026213, PubMed:10864329, PubMed:15647753, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:22224423). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:15647753). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:21685874). Component of the ADA histone acetyltransferase complex, which preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (PubMed:10026213). SGF29 is also required for heterochromatin boundary formation function, prevention of the spread of gene silencing at the HMR locus (PubMed:24307402)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR02;P87008", "ec_number_list": "", "go_molecular_function": "GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000124 SAGA complex;GO:0140671 ADA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008104 intracellular protein localization;GO:0072742 SAGA complex localization to transcription regulatory region", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P25554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25627-1", "uniprot_id": "BUD23_YEAST", "mass": 30742.0, "length": 275, "protein_name": "18S rRNA (guanine(1575)-N(7))-methyltransferase", "gene_name": "BUD23", "organism": "Yeast", "refseq_name": "18S rRNA (guanine1575-N7)-methyltransferase", "refseq_ac": "NP_009976", "gene_names_uniprotkb": "BUD23; YCR47C", "gene_names_refseq": "BUD23", "protein_names_uniprotkb": "18S rRNA (guanine(1575)-N(7))-methyltransferase; 2.1.1.309; Bud site selection protein 23", "protein_names_refseq": "18S rRNA (guanine1575-N7)-methyltransferase", "tax_id": 559292, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (sce:YCR047C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11452010;12872006;1304897;14562095;14562106;1574125;17322287;18332120;22493060;22956767;23233232;23604635;24374639;24710271;33491328;9873020", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of guanine 1575 (m7G1575) in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Required for efficient cleavage of the primary 35S precursor rRNA at site A2. Involved in positioning the proximal bud pole signal., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR56", "ec_number_list": "2.1.1.309;2.7.11.1;3.1.26.5;3.1.-.-;3.6.1.-", "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070476 rRNA (guanine-N7)-methylation;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P25627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27999-1", "uniprot_id": "RPB9_YEAST", "mass": 14288.0, "length": 122, "protein_name": "DNA-directed RNA polymerase II subunit RPB9", "gene_name": "RPB9", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase II core subunit RPB9", "refseq_ac": "NP_011445", "gene_names_uniprotkb": "RPB9", "gene_names_refseq": "RPB9; SSU73", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB9; B12.6; DNA-directed RNA polymerase II 14.2 kDa polypeptide; DNA-directed RNA polymerase II subunit 9; RNA polymerase II subunit B9", "protein_names_refseq": "DNA-directed RNA polymerase II core subunit RPB9", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL070C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 16, "publication_count": 24, "publication_id_list": "10938084;11313498;11313499;11805306;12411509;12746495;12746498;12914699;14562106;14580350;14963322;15537538;15591044;15610738;16341226;16765890;17322287;18407956;1918023;24374639;33481703;33491328;9169869;9290212", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation. Involved in DNA repair of damage in the transcribed strand. Mediates a transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU72", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P27999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30822-1", "uniprot_id": "XPO1_YEAST", "mass": 124104.0, "length": 1084, "protein_name": "Exportin-1", "gene_name": "CRM1", "organism": "Yeast", "refseq_name": "exportin CRM1", "refseq_ac": "NP_011734", "gene_names_uniprotkb": "CRM1; G8514; KAP124; XPO1", "gene_names_refseq": "CRM1; KAP124; XPO1", "protein_names_uniprotkb": "Exportin-1; Chromosome region maintenance protein 1; Karyopherin-124", "protein_names_refseq": "exportin CRM1", "tax_id": 559292, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); extrahepatic bile duct carcinoma (Disease Ontology:DOID:4682); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YGR218W); (R-SCE-5687128); (R-SCE-9856649)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "1448080;14562095;14562106;15020406;15769879;18407956;19779198;24374639;33491328;8701610;9169869;9323132", "class_list": "", "function": "Receptor for the leucine-rich nuclear export signal (NES)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV01", "ec_number_list": "", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0030620 U2 snRNA binding;GO:0031267 small GTPase binding;GO:0030619 U1 snRNA binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000776 kinetochore;GO:0005816 spindle pole body", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0071528 tRNA re-export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006409 tRNA export from nucleus;GO:0051168 nuclear export", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P30822-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32366-1", "uniprot_id": "VA0D_YEAST", "mass": 39791.0, "length": 345, "protein_name": "V-type proton ATPase subunit d", "gene_name": "VMA6", "organism": "Yeast", "refseq_name": "H(+)-transporting V0 sector ATPase subunit d", "refseq_ac": "NP_013552", "gene_names_uniprotkb": "VMA6; L9324.8", "gene_names_refseq": "VMA6", "protein_names_uniprotkb": "V-type proton ATPase subunit d; V-ATPase 39 kDa subunit; V-ATPase subunit M39; V-ATPase subunit d; Vacuolar proton pump subunit d", "protein_names_refseq": "H(+)-transporting V0 sector ATPase subunit d", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (sce:YLR447C); (R-SCE-1222556); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "14562095;14562106;22814378;24374639;27776355;29526695;33481703;8509410;9169871", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8509410). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8509410). This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector (PubMed:8509410). Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (PubMed:8509410)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ81", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32529-1", "uniprot_id": "RPA12_YEAST", "mass": 13661.0, "length": 125, "protein_name": "DNA-directed RNA polymerase I subunit RPA12", "gene_name": "RPA12", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase I core subunit RPA12", "refseq_ac": "NP_012597", "gene_names_uniprotkb": "RPA12; J1747; RRN4", "gene_names_refseq": "RPA12; RRN4", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA12; A12.2; A12; DNA-directed RNA polymerase I 13.7 kDa polypeptide", "protein_names_refseq": "DNA-directed RNA polymerase I core subunit RPA12", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR063W); (R-SCE-73762); (R-SCE-73772)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11918799;12145213;12407181;14562095;14562106;15073335;17322287;18160037;18407956;24153182;24153184;24374639;33481703;33491328;8417319;8641269;8840504", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Proposed to contribute to the polymerase catalytic activity and form the polymerase active center together with the two largest subunits. Subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. Involved in transcriptional termination., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWN4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32529-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32863-1", "uniprot_id": "RAD54_YEAST", "mass": 101754.0, "length": 898, "protein_name": "DNA repair and recombination protein RAD54", "gene_name": "RAD54", "organism": "Yeast", "refseq_name": "DNA-dependent ATPase RAD54", "refseq_ac": "NP_011352", "gene_names_uniprotkb": "RAD54; G1821", "gene_names_refseq": "RAD54; XRS1", "protein_names_uniprotkb": "DNA repair and recombination protein RAD54; 3.6.4.-", "protein_names_refseq": "DNA-dependent ATPase RAD54", "tax_id": 559292, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); sclerocornea (Disease Ontology:DOID:0060252); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (sce:YGL163C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12453424;17563356;18407956;1916269;19917248;20190278;21126336;23749301;24374639;31492866;32502392;32597660;33481703;33491328;7610042;8585324;9169869;9590697", "class_list": "", "function": "Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:12453424). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism (PubMed:32502392). Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized (PubMed:31492866). Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (PubMed:12453424)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTY8", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0015616 DNA translocase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007131 reciprocal meiotic recombination;GO:0000722 telomere maintenance via recombination;GO:0032392 DNA geometric change;GO:0030491 heteroduplex formation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32908-1", "uniprot_id": "SMC1_YEAST", "mass": 141280.0, "length": 1225, "protein_name": "Structural maintenance of chromosomes protein 1", "gene_name": "SMC1", "organism": "Yeast", "refseq_name": "cohesin subunit SMC1", "refseq_ac": "NP_116647", "gene_names_uniprotkb": "SMC1; CHL10", "gene_names_refseq": "CHL10; SMC1", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 1; DA-box protein SMC1", "protein_names_refseq": "cohesin subunit SMC1", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 85 (Disease Ontology:DOID:0070380); Cornelia de Lange syndrome 2 (Disease Ontology:DOID:0080506); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YFL008W); (R-SCE-2468052); (R-SCE-2500257); (R-SCE-3108214)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11983169;14562106;18407956;19795423;19823750;21126336;22031224;23749301;24374639;33481703;33491328;7670463;8276886;9990856", "class_list": "", "function": "Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTM2", "ec_number_list": "", "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0005634 nucleus;GO:0008278 cohesin complex", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0000070 mitotic sister chromatid segregation;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32908-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36037-1", "uniprot_id": "DOA1_YEAST", "mass": 79506.0, "length": 715, "protein_name": "Protein DOA1", "gene_name": "DOA1", "organism": "Yeast", "refseq_name": "Doa1p", "refseq_ac": "NP_012709", "gene_names_uniprotkb": "DOA1; UFD3; ZZZ4", "gene_names_refseq": "DOA1; UFD3; ZZZ4", "protein_names_uniprotkb": "Protein DOA1; Degradation of alpha protein 1; Ubiquitin fusion degradation protein 3", "protein_names_refseq": "Doa1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL213C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "14562095;14562106;15096053;16427015;16428438;17563356;18407956;18508771;19779198;19795423;19805280;19823750;20508643;21063153;21070969;2111732;21126336;22814378;23525333;23749301;24374639;27044889;32597660;33229814;33481703;33491328;7615550;7941750;8196765;8890162", "class_list": "", "function": "Ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation (PubMed:18508771, PubMed:19805280, PubMed:20508643, PubMed:2111732, PubMed:27044889, PubMed:8890162). Acts as a ubiquitinated substrate-recruiting adapter for chaperone ATPase CDC48 by binding mono- or polyubiquitin chains (PubMed:15096053, PubMed:16427015, PubMed:16428438, PubMed:27044889). Depending on the context, promotes or prevents proteasomal degradation of ubiquitinated proteins (PubMed:19805280, PubMed:2111732, PubMed:27044889, PubMed:8890162). Involved in the ubiquitin fusion degradation (UFD) pathway by promoting the degradation of ubiquitinated proteins (PubMed:19805280, PubMed:2111732, PubMed:27044889, PubMed:8890162). Involved in the mitochondria-associated degradation pathway (MAD) by promoting the degradation of several ubiquitinated membrane proteins (PubMed:27044889). By competing with UFD2 to bind CDC48, prevents the multi-ubiquitination and subsequent degradation of UFD2-dependent substrates (PubMed:16427015). Required for ribophagy, a process which relocalizes ribosomal particles into the vacuole for degradation in response to starvation (PubMed:20508643). Involved in the ubiquitin-mediated sorting of membrane proteins into multivesicular bodies (MVBs) (PubMed:18508771). In addition, plays an essential role in maintaining cellular ubiquitin levels (PubMed:16427015, PubMed:16428438, PubMed:18508771, PubMed:19805280, PubMed:7615550). May affect indirectly the degradation of ubiquitinylated proteins by regulating cellular ubiquitin levels (PubMed:23525333, PubMed:7615550)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ0", "ec_number_list": "", "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0140036 ubiquitin-modified protein reader activity;GO:0044877 protein-containing complex binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010008 endosome membrane;GO:0032473 cytoplasmic side of mitochondrial outer membrane", "go_biological_process": "GO:0010992 ubiquitin recycling;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process;GO:0070314 G1 to G0 transition", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P36037-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38182-1", "uniprot_id": "ATG8_YEAST", "mass": 13627.0, "length": 117, "protein_name": "Autophagy-related protein 8", "gene_name": "ATG8", "organism": "Yeast", "refseq_name": "ubiquitin-like protein ATG8", "refseq_ac": "NP_009475", "gene_names_uniprotkb": "ATG8; APG8; AUT7; CVT5; YBL0732", "gene_names_refseq": "APG8; ATG8; AUT7; CVT5", "protein_names_uniprotkb": "Autophagy-related protein 8; Autophagy-related ubiquitin-like modifier ATG8; Cytoplasm to vacuole targeting protein 5", "protein_names_refseq": "ubiquitin-like protein ATG8", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); liver cirrhosis (Disease Ontology:DOID:5082); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (sce:YBL078C); (R-SCE-1632852); (R-SCE-8854214); (R-SCE-8934903)", "pathway_count": 4, "publication_count": 72, "publication_id_list": "10525546;10681575;10837468;11038174;11100732;11139573;11149920;11675395;11689437;12479808;14536056;14562106;15155809;15194695;15277523;15449304;15659643;16079147;16221887;16680092;17132049;17295840;17322287;17404498;17632063;17699586;17700056;18077553;18508918;18625846;18725539;19021777;19088501;19285500;19398890;19619494;20065092;20154084;20382112;20428927;20615880;20639194;20855502;20855505;20952643;21429936;22055191;22056771;22144692;22240591;22308029;22539722;22622160;22652539;22733735;22768199;22778255;22814378;22885598;23064152;23549786;24374639;28330855;30510114;34088313;38832010;38964378;7502586;7593182;7813418;8224160;9649430", "class_list": "", "function": "Has a lipidation-independent vacuolar function to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT) when cells enter stationary phase., [UniProtKB, PubMed]; Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosome formation (PubMed:10525546, PubMed:10681575, PubMed:10837468, PubMed:11038174, PubMed:11149920, PubMed:16680092, PubMed:18508918, PubMed:19398890, PubMed:21429936, PubMed:7593182, PubMed:8224160). With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton (PubMed:9649430). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:17404498, PubMed:22768199). Also participates in membrane fusion events that take place in the early secretory pathway (PubMed:10837468). Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (PubMed:17132049). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (PubMed:11100732, PubMed:17632063, PubMed:20855502). Moreover not only conjugation, but also subsequent ATG8-PE deconjugation is an important step required to facilitate multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components (PubMed:17632063, PubMed:20855502, PubMed:22622160). Also plays a role in regulation of filamentous growth (PubMed:17700056)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPS5", "ec_number_list": "", "go_molecular_function": "GO:0008429 phosphatidylethanolamine binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0016241 regulation of macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 7.3, "record_id": "P38182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39875-1", "uniprot_id": "EXO1_YEAST", "mass": 80162.0, "length": 702, "protein_name": "Exodeoxyribonuclease 1", "gene_name": "EXO1", "organism": "Yeast", "refseq_name": "Rad2 family nuclease EXO1", "refseq_ac": "NP_014676", "gene_names_uniprotkb": "EXO1; DHS1; OR26.23", "gene_names_refseq": "DHS1; EXO1", "protein_names_uniprotkb": "Exodeoxyribonuclease 1; 3.1.-.-; EXO I; Exodeoxyribonuclease I; Exonuclease I; Protein DHS1", "protein_names_refseq": "Rad2 family nuclease EXO1", "tax_id": 559292, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (sce:YOR033C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11102356;14562106;15629726;17563356;18407956;18756267;24374639;32020204;33491328;7764548;9111347;9169874;9207118", "class_list": "", "function": "5'->3' double-stranded DNA exonuclease involved in mismatch repair and eventually also in mitotic recombination between direct repeats. Also has a minor role in the correction of large DNA mismatches that occur in the heteroduplex DNA during meiotic recombination at the HIS4 locus., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W299", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006298 mismatch repair;GO:0000706 meiotic DNA double-strand break processing;GO:0000729 DNA double-strand break processing;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P39875-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40395-1", "uniprot_id": "RIC1_YEAST", "mass": 121650.0, "length": 1056, "protein_name": "Guanine nucleotide exchange factor subunit RIC1", "gene_name": "RIC1", "organism": "Yeast", "refseq_name": "Ric1p", "refseq_ac": "NP_013140", "gene_names_uniprotkb": "RIC1", "gene_names_refseq": "RIC1", "protein_names_uniprotkb": "Guanine nucleotide exchange factor subunit RIC1; Protein RIC1; Ribosome control protein 1; Ric1p", "protein_names_refseq": "Ric1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR039C); (R-SCE-6811440); (R-SCE-8876198)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10990452;11160819;11689439;14562095;14562106;24374639;33491328;9169871", "class_list": "", "function": "The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates YPT6 by exchanging bound GDP for free GTP. It is thereby required for efficient fusion of endosome-derived vesicles with the Golgi. The RIC1-RGP1 participates in the recycling of SNC1, presumably by mediating fusion of endosomal vesicles with the Golgi compartment. May also be indirectly involved in the transcription of both ribosomal protein genes and ribosomal RNA., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY42", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40395-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47017-1", "uniprot_id": "LSM1_YEAST", "mass": 20307.0, "length": 172, "protein_name": "LSM1-LSM7 complex subunit LSM1", "gene_name": "LSM1", "organism": "Yeast", "refseq_name": "Lsm1p", "refseq_ac": "NP_012411", "gene_names_uniprotkb": "LSM1; J0714; SPB8", "gene_names_refseq": "LSM1; SPB8", "protein_names_uniprotkb": "LSM1-LSM7 complex subunit LSM1; SPB8 protein", "protein_names_refseq": "Lsm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL124C); (R-SCE-430039)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10747033;10761922;10913177;14562095;14562106;17322287;24139796;24374639;24513854;30059503;32597660;33491328;8641269;8948101;9710590", "class_list": "", "function": "Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step (PubMed:10747033, PubMed:10913177, PubMed:10761922, PubMed:24513854). Together with PAT1, the LSM1-LSM7 complex binds to osmotic stress-activated mRNAs to attenuate the osmotic stress response, probably by limiting ribosome access to the mRNA and consequently translation (PubMed:30059503)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW62", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:1990904 ribonucleoprotein complex;GO:1990726 Lsm1-7-Pat1 complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397 mRNA processing;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P47017-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49334-1", "uniprot_id": "TOM22_YEAST", "mass": 16790.0, "length": 152, "protein_name": "Mitochondrial import receptor subunit TOM22", "gene_name": "TOM22", "organism": "Yeast", "refseq_name": "Tom22p", "refseq_ac": "NP_014268", "gene_names_uniprotkb": "TOM22; MAS17; MAS22; MOM22; N1217; N1862", "gene_names_refseq": "MAS17; MAS22; MOM22; TOM22", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM22; Mitochondrial 17 kDa assembly protein; Mitochondrial 22 kDa outer membrane protein; Protein MAS17; Translocase of outer membrane 22 kDa subunit", "protein_names_refseq": "Tom22p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL131W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10519552;11276259;14562106;18407956;19684113;19779198;19795423;19823750;20702584;21177495;21944719;22118465;22814378;23749301;24374639;30516470;33481703;33491328;34965436;7760834;7805891;7991567;8619318;9169873;9774667", "class_list": "", "function": "Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W151;Q36757", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P49334-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54860-1", "uniprot_id": "UFD2_YEAST", "mass": 109916.0, "length": 961, "protein_name": "E4 ubiquitin-protein ligase UFD2", "gene_name": "UFD2", "organism": "Yeast", "refseq_name": "ubiquitin-ubiquitin ligase UFD2", "refseq_ac": "NP_010091", "gene_names_uniprotkb": "UFD2; D1255", "gene_names_refseq": "UFD2", "protein_names_uniprotkb": "E4 ubiquitin-protein ligase UFD2; 2.3.2.27; RING-type E3 ubiquitin transferase UFD2; UB fusion protein 2; Ubiquitin conjugation factor E4; Ubiquitin fusion degradation protein 2", "protein_names_refseq": "ubiquitin-ubiquitin ligase UFD2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL190C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10089879;14562095;14562106;15121879;15240124;15652483;16427015;17890322;18191224;20159987;20427284;21126336;22814378;24374639;33491328;7615550;8896272;9169867", "class_list": "", "function": "E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to CDC48 and elongates mono- and diubiquitinated ERAD substrates presented by the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to RAD23 and DSK2, which target them to the proteasome. Has E3 ubiquitin-protein ligase activity, accepting ubiquitin from its cognate E2 ubiquitin-conjugating enzyme UBC4. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. Promotes ubiquitin chain elongation at 'Lys-48' on the DOA10 substrate PEX29. Also involved in the proteolytic processing of the ER-bound transcription factor SPT23., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRG3", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0071361 cellular response to ethanol;GO:0016567 protein ubiquitination;GO:0031398 positive regulation of protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P54860-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03020-1", "uniprot_id": "ISU1_YEAST", "mass": 17895.0, "length": 165, "protein_name": "Iron sulfur cluster assembly protein 1, mitochondrial", "gene_name": "ISU1", "organism": "Yeast", "refseq_name": "iron-binding protein ISU1", "refseq_ac": "NP_015190", "gene_names_uniprotkb": "ISU1; NUA1", "gene_names_refseq": "ISU1; NUA1", "protein_names_uniprotkb": "Iron sulfur cluster assembly protein 1, mitochondrial; Iron sulfur cluster scaffold protein 1", "protein_names_refseq": "iron-binding protein ISU1", "tax_id": 559292, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (sce:YPL135W); (R-SCE-1362409); (R-SCE-9865881)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10468587;10588895;12756240;12947415;12970193;14562106;14741370;15123690;15143178;16341089;16431909;16823961;20815377;22306468;23615440;23946486;24374639;25228696;25358379;25973573;26941001;27738674;28548666;31040179;9169875", "class_list": "", "function": "Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:10588895, PubMed:12970193, PubMed:14741370, PubMed:15123690, PubMed:16341089, PubMed:27738674, PubMed:31040179). First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2 (PubMed:12970193, PubMed:16341089, PubMed:31040179). In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins (PubMed:12970193, PubMed:23615440). Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH (PubMed:12970193, PubMed:14741370, PubMed:16341089, PubMed:25358379, PubMed:31040179). Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1 (PubMed:14741370, PubMed:15123690, PubMed:16431909, PubMed:23615440, PubMed:31040179). ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (PubMed:10588895). Also involved in production of a sulfur precursor required for thiolation of cytoplasmic tRNAs (PubMed:31040179)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3N2", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008198 ferrous iron binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q03020-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08491-1", "uniprot_id": "SKI7_YEAST", "mass": 84779.0, "length": 747, "protein_name": "Superkiller protein 7", "gene_name": "SKI7", "organism": "Yeast", "refseq_name": "Ski7p", "refseq_ac": "NP_014719", "gene_names_uniprotkb": "SKI7; YOR29-27", "gene_names_refseq": "SKI7", "protein_names_uniprotkb": "Superkiller protein 7", "protein_names_refseq": "Ski7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR076C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10074137;11027292;11514438;11532933;11910110;12730603;12769863;12881429;14562106;14671320;15933721;16043509;16829593;17173052;17287358;18407956;19046973;24374639;32597660;33491328;6371496;9133743;9169874", "class_list": "", "function": "Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD). May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2D9;O00032", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0070651 nonfunctional rRNA decay;GO:0006417 regulation of translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q08491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12019-1", "uniprot_id": "MDN1_YEAST", "mass": 559308.0, "length": 4910, "protein_name": "Midasin", "gene_name": "MDN1", "organism": "Yeast", "refseq_name": "AAA family ATPase midasin", "refseq_ac": "NP_013207", "gene_names_uniprotkb": "MDN1; L2901; L8004.13; REA1", "gene_names_refseq": "MDN1; REA1", "protein_names_uniprotkb": "Midasin; Dynein-related AAA-ATPase REA1; MIDAS-containing protein; Ribosome export/assembly protein 1", "protein_names_refseq": "AAA family ATPase midasin", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR106C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "11583615;12102729;12374754;14562106;15260980;15528184;17330950;18407956;19684113;19737519;19779198;19795423;19823750;20542003;21126336;21177495;22218487;23749301;24240281;24374639;26619264;32597660;33481703;33491328;9090053;9169871", "class_list": "", "function": "Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (PubMed:15260980, PubMed:15528184, PubMed:19737519, PubMed:20542003). At an early stage in 60S maturation, mediates the dissociation of the NOP7 complex (YTM1-ERB1-NOP7) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (PubMed:20542003). Subsequently recruited to the nucleoplasmic particles through interaction with the RIX1 complex. This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (PubMed:26619264). After remodeling, removes the ribosome biogenesis factor RSA4 in an ATP hydrolysis-driven step from pre-60S ribosomal subunits, rendering them competent for export from the nucleoplasm to the cytoplasm (PubMed:19737519, PubMed:20542003). Activates the GTPase activity of NOG2, which disengages from the pre-60S particle upon GTP hydrolysis, thus freeing its binding site for the nuclear export factor NMD3 (PubMed:24240281)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYA6;Q7LGX0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly;GO:2000200 regulation of ribosomal subunit export from nucleus;GO:0110136 protein-RNA complex remodeling", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q12019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12133-1", "uniprot_id": "SPC3_YEAST", "mass": 21349.0, "length": 184, "protein_name": "Signal peptidase complex subunit 3", "gene_name": "SPC3", "organism": "Yeast", "refseq_name": "signal peptidase complex subunit SPC3", "refseq_ac": "NP_013167", "gene_names_uniprotkb": "SPC3; L2186", "gene_names_refseq": "SPC3", "protein_names_uniprotkb": "Signal peptidase complex subunit 3; Microsomal signal peptidase subunit 3", "protein_names_refseq": "signal peptidase complex subunit SPC3", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR066W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10206957;14562095;14562106;17322287;22814378;24374639;9148930;9148931;9169871", "class_list": "", "function": "Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:9148930, PubMed:9148931). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (PubMed:9148930, PubMed:9148931). Essential for viability (PubMed:9148930, PubMed:9148931)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VY67", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12133-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12136-1", "uniprot_id": "SAS10_YEAST", "mass": 70259.0, "length": 610, "protein_name": "Something about silencing protein 10", "gene_name": "SAS10", "organism": "Yeast", "refseq_name": "rRNA-processing protein SAS10", "refseq_ac": "NP_010128", "gene_names_uniprotkb": "SAS10; D1545; UTP3", "gene_names_refseq": "SAS10; UTP3", "protein_names_uniprotkb": "Something about silencing protein 10; U three protein 3; U3 small nucleolar RNA-associated protein 3; U3 snoRNA-associated protein 11", "protein_names_refseq": "rRNA-processing protein SAS10", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL153C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "12068309;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8972581;9169867;9611201", "class_list": "", "function": "Primarily required at the G2/M phase. Essential for viability: involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRJ7;Q05842", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q12136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12154-1", "uniprot_id": "GET3_YEAST", "mass": 39354.0, "length": 354, "protein_name": "ATPase GET3", "gene_name": "GET3", "organism": "Yeast", "refseq_name": "guanine nucleotide exchange factor GET3", "refseq_ac": "NP_010183", "gene_names_uniprotkb": "GET3; ARR4; D2371", "gene_names_refseq": "ARR4; GET3", "protein_names_uniprotkb": "ATPase GET3; 3.6.-.-; Arsenical pump-driving ATPase; Arsenite-stimulated ATPase; Golgi to ER traffic protein 3; Guided entry of tail-anchored proteins 3", "protein_names_refseq": "guanine nucleotide exchange factor GET3", "tax_id": 559292, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDL100C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11805837;12680698;14562095;14562106;16260785;16269340;16816426;17322287;18724936;19675567;19706470;19956640;20015340;21719644;21866104;22684149;24374639;24392163;32910895;33481703;8923743;9169867", "class_list": "", "function": "ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRQ0;Q6B1B6", "ec_number_list": "3.6.-.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0043529 GET complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0045048 protein insertion into ER membrane;GO:0046685 response to arsenic-containing substance;GO:0034599 cellular response to oxidative stress;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q12154-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07884-1", "uniprot_id": "MOD5_YEAST", "mass": 50237.0, "length": 428, "protein_name": "tRNA dimethylallyltransferase", "gene_name": "MOD5", "organism": "Yeast", "refseq_name": "tRNA dimethylallyltransferase", "refseq_ac": "NP_014917", "gene_names_uniprotkb": "MOD5", "gene_names_refseq": "MOD5", "protein_names_uniprotkb": "tRNA dimethylallyltransferase; 2.5.1.75; DMATase; IPP transferase; IPPT; IPTase; Isopentenyl-diphosphate: tRNA isopentenyltransferase; tRNA isopentenyltransferase", "protein_names_refseq": "tRNA dimethylallyltransferase", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 35 (Disease Ontology:DOID:0111464); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (sce:YOR274W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10618371;14562106;1850093;18852462;1946403;21873461;22517861;24374639;3031456;3031457;8139535;8896271;9169874", "class_list": "", "function": "Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity. Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2X4;Q12203", "ec_number_list": "2.5.1.75", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0052381 tRNA dimethylallyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C0W9-1", "uniprot_id": "RL11A_YEAST", "mass": 19720.0, "length": 174, "protein_name": "Large ribosomal subunit protein uL5A", "gene_name": "RPL11A", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL5 RPL11A", "refseq_ac": "NP_015427", "gene_names_uniprotkb": "RPL11A; P8283.14; RP39A; RPL16A", "gene_names_refseq": "RPL11A", "protein_names_uniprotkb": "Large ribosomal subunit protein uL5A; 60S ribosomal protein L11-A; L16; RP39; YL22", "protein_names_refseq": "60S ribosomal protein uL5 RPL11A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 7 (Disease Ontology:DOID:0111878); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (sce:YPR102C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 22, "publication_id_list": "10601260;11283598;11701127;14562095;14562106;14976550;1544921;17287358;17322287;21109664;22096102;22522802;22814378;23118189;24374639;24524803;32597660;37291423;6090215;7510288;9169875;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4A0;P06380", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P0C0W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32048-1", "uniprot_id": "SYKM_YEAST", "mass": 66128.0, "length": 576, "protein_name": "Lysine--tRNA ligase, mitochondrial", "gene_name": "MSK1", "organism": "Yeast", "refseq_name": "lysine--tRNA ligase MSK1", "refseq_ac": "NP_014326", "gene_names_uniprotkb": "MSK1; N2364", "gene_names_refseq": "MSK1", "protein_names_uniprotkb": "Lysine--tRNA ligase, mitochondrial; 6.1.1.6; LysRS; Lysyl-tRNA synthetase", "protein_names_refseq": "lysine--tRNA ligase MSK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL073W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;18407956;2016746;24374639;8701611;9169873", "class_list": "", "function": "Catalyzes the attachment of lysine to tRNA(Lys) in the mitochondrion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1A6", "ec_number_list": "6.1.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004824 lysine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0008033 tRNA processing;GO:0032543 mitochondrial translation;GO:0006430 lysyl-tRNA aminoacylation;GO:0070154 mitochondrial lysyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32190-1", "uniprot_id": "GLPK_YEAST", "mass": 79824.0, "length": 709, "protein_name": "Glycerol kinase", "gene_name": "GUT1", "organism": "Yeast", "refseq_name": "glycerol kinase", "refseq_ac": "NP_011831", "gene_names_uniprotkb": "GUT1", "gene_names_refseq": "GUT1", "protein_names_uniprotkb": "Glycerol kinase; 2.7.1.30; ATP:glycerol 3-phosphotransferase; GK; Glycerokinase", "protein_names_refseq": "glycerol kinase", "tax_id": 559292, "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363); familial hypercholesterolemia (Disease Ontology:DOID:13810)", "pathway": " (sce:YHL032C); (R-SCE-75109)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17563356;24374639;32597660;33229814;33491328;8091229;8358828", "class_list": "", "function": "Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DKT6", "ec_number_list": "2.7.1.30", "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32190-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32191-1", "uniprot_id": "GPDM_YEAST", "mass": 72389.0, "length": 649, "protein_name": "Glycerol-3-phosphate dehydrogenase, mitochondrial", "gene_name": "GUT2", "organism": "Yeast", "refseq_name": "glycerol-3-phosphate dehydrogenase", "refseq_ac": "NP_012111", "gene_names_uniprotkb": "GUT2", "gene_names_refseq": "GUT2", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase, mitochondrial; 1.1.5.3; GPD-M; GPDH-M", "protein_names_refseq": "glycerol-3-phosphate dehydrogenase", "tax_id": 559292, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YIL155C); (R-SCE-1483166); (R-SCE-163560)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11502169;14562106;17322287;21126336;22984289;24374639;33491328;8256521;9169870", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVD2;E9P8Y2", "ec_number_list": "1.1.5.3", "go_molecular_function": "GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0006127 glycerol-3-phosphate shuttle;GO:0006071 glycerol metabolic process;GO:0006072 glycerol-3-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32191-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32263-1", "uniprot_id": "P5CR_YEAST", "mass": 30132.0, "length": 286, "protein_name": "Pyrroline-5-carboxylate reductase", "gene_name": "PRO3", "organism": "Yeast", "refseq_name": "pyrroline-5-carboxylate reductase", "refseq_ac": "NP_010940", "gene_names_uniprotkb": "PRO3; ORE2", "gene_names_refseq": "ORE2; PRO3", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase; 1.5.1.2; P5C reductase; P5CR", "protein_names_refseq": "pyrroline-5-carboxylate reductase", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy 10 (Disease Ontology:DOID:0060788); autosomal recessive cutis laxa type IIB (Disease Ontology:DOID:0070137); autosomal recessive cutis laxa type IIIB (Disease Ontology:DOID:0070138)", "pathway": " (sce:YER023W); (R-SCE-8964539)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;1508147;1592829;18407956;22106047;23749301;24374639;32597660;33481703;33491328;9169868", "class_list": "", "function": "Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline, the final step in proline biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS2", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32331-1", "uniprot_id": "YMC1_YEAST", "mass": 33376.0, "length": 307, "protein_name": "Mitochondrial glycine transporter YMC1", "gene_name": "YMC1", "organism": "Yeast", "refseq_name": "organic acid transporter", "refseq_ac": "NP_015383", "gene_names_uniprotkb": "YMC1; YP9499.14", "gene_names_refseq": "YMC1", "protein_names_uniprotkb": "Mitochondrial glycine transporter YMC1; Yeast mitochondrial carrier protein 1", "protein_names_refseq": "organic acid transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR058W); (R-SCE-70635)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10930523;16823961;24374639;26821380;29897761;8488731;9169875", "class_list": "", "function": "Secondary mitochondrial glycine transporter required for the biosynthesis of heme at high glycine concentrations. Imports the precursor glycine into the mitochondrial matrix, where it is condensed with succinyl-CoA to produce 5-aminolevulinate (ALA), the first step of heme biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W464;Q12002", "ec_number_list": "", "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0006783 heme biosynthetic process;GO:1990575 mitochondrial L-ornithine transmembrane transport;GO:1904983 glycine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32331-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32339-1", "uniprot_id": "HMX1_YEAST", "mass": 37179.0, "length": 317, "protein_name": "Heme-binding protein HMX1", "gene_name": "HMX1", "organism": "Yeast", "refseq_name": "Hmx1p", "refseq_ac": "NP_013306", "gene_names_uniprotkb": "HMX1; L8167.18", "gene_names_refseq": "HMX1", "protein_names_uniprotkb": "Heme-binding protein HMX1", "protein_names_refseq": "Hmx1p", "tax_id": 559292, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); Parkinsonism (Disease Ontology:DOID:0080855); berylliosis (Disease Ontology:DOID:10322); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); IgA vasculitis (Disease Ontology:DOID:11123); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); varicocele (Disease Ontology:DOID:12337); malaria (Disease Ontology:DOID:12365); retinal ischemia (Disease Ontology:DOID:12510); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Sjogren's syndrome (Disease Ontology:DOID:12894); intracranial vasospasm (Disease Ontology:DOID:13100); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); pneumothorax (Disease Ontology:DOID:1673); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); hemochromatosis (Disease Ontology:DOID:2352); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); coronary restenosis (Disease Ontology:DOID:4247); brain edema (Disease Ontology:DOID:4724); esophageal cancer (Disease Ontology:DOID:5041); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); ileus (Disease Ontology:DOID:8440); lung disease (Disease Ontology:DOID:850); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (sce:YLR205C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11112771;11566881;12699699;12840010;12844361;1523888;24374639;9169871", "class_list": "", "function": "Plays an important role in the degradation of heme under conditions of iron deprivation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK6;Q05782;Q86ZS9", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006879 intracellular iron ion homeostasis;GO:0042167 heme catabolic process;GO:0006788 heme oxidation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32341-1", "uniprot_id": "VPH2_YEAST", "mass": 25287.0, "length": 215, "protein_name": "Vacuolar ATPase assembly integral membrane protein VPH2", "gene_name": "VPH2", "organism": "Yeast", "refseq_name": "Vph2p", "refseq_ac": "NP_012803", "gene_names_uniprotkb": "VPH2; CLS10; VMA12; YKL520", "gene_names_refseq": "CLS10; VMA12; VPH2", "protein_names_uniprotkb": "Vacuolar ATPase assembly integral membrane protein VPH2; Protein VMA12", "protein_names_refseq": "Vph2p", "tax_id": 559292, "disease": "congenital disorder of glycosylation type IIp (Disease Ontology:DOID:0070268)", "pathway": " (sce:YKL119C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;1514329;1561835;16847258;19779198;22814378;24374639;33481703;33491328;8196765;8419376;8465604;9325326", "class_list": "", "function": "Required for vacuolar ATPase assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXH1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:1990871 Vma12-Vma22 assembly complex", "go_biological_process": "GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32343-1", "uniprot_id": "SSH4_YEAST", "mass": 65061.0, "length": 579, "protein_name": "Protein SSH4", "gene_name": "SSH4", "organism": "Yeast", "refseq_name": "Ssh4p", "refseq_ac": "NP_012798", "gene_names_uniprotkb": "SSH4; MLF4; YKL529", "gene_names_refseq": "MLF4; SSH4", "protein_names_uniprotkb": "Protein SSH4; Multicopy suppressor of leflunomide protein 4; Suppressor of SHR3 null mutation protein 4", "protein_names_refseq": "Ssh4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL124W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;1514329;17287526;17330950;18407956;19779198;20702584;22106047;22218487;23749301;24374639;24909858;32597660;33481703;33491328;8196765;9610367", "class_list": "", "function": "Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane. Confers leflunomide resistance when overexpressed., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VX71", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0010008 endosome membrane;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32343-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32344-1", "uniprot_id": "COX24_YEAST", "mass": 12772.0, "length": 111, "protein_name": "Small ribosomal subunit protein bS22, mitochondrial", "gene_name": "QRI5", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein mS38 QRI5", "refseq_ac": "NP_013305", "gene_names_uniprotkb": "QRI5; COX24", "gene_names_refseq": "COX24; QRI5; mS38", "protein_names_uniprotkb": "Small ribosomal subunit protein bS22, mitochondrial; Mitochondrial mRNA-processing protein COX24; Small ribosomal subunit protein mS38", "protein_names_refseq": "mitochondrial 37S ribosomal protein mS38 QRI5", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR204W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;1523888;16339141;17322287;24374639;25609543;28154081;30968120;38199006;6297789;9169871", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable) (PubMed:30968120). Preferentially stimulates translation initiation of COX1, COX2, and COX3 mRNAs (PubMed:30968120). mS38 is also involved in the splicing of the COX1 mRNA (PubMed:16339141)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0006397 mRNA processing;GO:0032543 mitochondrial translation;GO:0061668 mitochondrial ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32352-1", "uniprot_id": "ERG2_YEAST", "mass": 24896.0, "length": 222, "protein_name": "C-8 sterol isomerase ERG2", "gene_name": "ERG2", "organism": "Yeast", "refseq_name": "C-8 sterol isomerase ERG2", "refseq_ac": "NP_013929", "gene_names_uniprotkb": "ERG2; YM8325.03", "gene_names_refseq": "END11; ERG2", "protein_names_uniprotkb": "C-8 sterol isomerase ERG2; 5.-.-.-; Delta-8--delta-7 sterol isomerase ERG2; Ergosterol biosynthetic protein 2", "protein_names_refseq": "C-8 sterol isomerase ERG2", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); amyotrophic lateral sclerosis type 16 (Disease Ontology:DOID:0060207); autosomal recessive distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111065); sciatic neuropathy (Disease Ontology:DOID:11446); post-traumatic stress disorder (Disease Ontology:DOID:2055); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (sce:YMR202W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10734216;14562106;15716577;17322287;1743517;24374639;32679672;33481703;37604855;9169872", "class_list": "", "function": "C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (Ref.5). ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (Ref.5). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W027", "ec_number_list": "5.-.-.-", "go_molecular_function": "GO:0000247 C-8 sterol isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32352-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32387-1", "uniprot_id": "RM41_YEAST", "mass": 30566.0, "length": 263, "protein_name": "Large ribosomal subunit protein uL23m", "gene_name": "MRP20", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL23m MRP20", "refseq_ac": "NP_010693", "gene_names_uniprotkb": "MRP20; D9509.23; MRPL41", "gene_names_refseq": "MRP20; uL23m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL23m; 54S ribosomal protein L41, mitochondrial; YmL41", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL23m MRP20", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR405W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;14576278;14657017;1544898;19684113;2060626;24374639;24675956;25609543;9151978;9169867", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT37", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32387-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32445-1", "uniprot_id": "RIM1_YEAST", "mass": 15386.0, "length": 135, "protein_name": "Single-stranded DNA-binding protein RIM1, mitochondrial", "gene_name": "RIM1", "organism": "Yeast", "refseq_name": "Rim1p", "refseq_ac": "NP_009958", "gene_names_uniprotkb": "RIM1; YCR28C-A", "gene_names_refseq": "RIM1", "protein_names_uniprotkb": "Single-stranded DNA-binding protein RIM1, mitochondrial; Mitochondrial ssDNA-binding protein", "protein_names_refseq": "Rim1p", "tax_id": 559292, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (sce:YCR028C-A); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1324172;1332309;14562106;1574125;23175612;24374639;30516470;32597660;33481703;33491328", "class_list": "", "function": "This protein binds preferentially and cooperatively to single-stranded DNA (ssDNS). Involved in mitochondrial DNA replication. Stimulates PIF1 helicase activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR39;O11851", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0090297 positive regulation of mitochondrial DNA replication;GO:0006260 DNA replication;GO:0006264 mitochondrial DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32449-1", "uniprot_id": "AROG_YEAST", "mass": 39749.0, "length": 370, "protein_name": "Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited", "gene_name": "ARO4", "organism": "Yeast", "refseq_name": "3-deoxy-7-phosphoheptulonate synthase ARO4", "refseq_ac": "NP_009808", "gene_names_uniprotkb": "ARO4; YBR1701", "gene_names_refseq": "ARO4", "protein_names_uniprotkb": "Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; 2.5.1.54; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase", "protein_names_refseq": "3-deoxy-7-phosphoheptulonate synthase ARO4", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR249C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12540830;1348717;14562106;15665377;18407956;19795423;19823750;22218487;22814378;23749301;24374639;24909858;30516470;33481703;33491328;7813418;8256522;8366040", "class_list": "", "function": "Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP5", "ec_number_list": "2.5.1.54", "go_molecular_function": "GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008652 amino acid biosynthetic process;GO:0043085 positive regulation of catalytic activity;GO:0009073 aromatic amino acid family biosynthetic process;GO:0009423 chorismate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32449-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32451-1", "uniprot_id": "BIOB_YEAST", "mass": 41884.0, "length": 375, "protein_name": "Biotin synthase, mitochondrial", "gene_name": "BIO2", "organism": "Yeast", "refseq_name": "biotin synthase", "refseq_ac": "NP_011802", "gene_names_uniprotkb": "BIO2", "gene_names_refseq": "BIO2", "protein_names_uniprotkb": "Biotin synthase, mitochondrial; 2.8.1.6", "protein_names_refseq": "biotin synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR286C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;24374639;8117110;9090054;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV63", "ec_number_list": "2.8.1.6", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004076 biotin synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009102 biotin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32451-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32459-1", "uniprot_id": "ALLA_YEAST", "mass": 21727.0, "length": 195, "protein_name": "Ureidoglycolate lyase", "gene_name": "DAL3", "organism": "Yeast", "refseq_name": "ureidoglycolate hydrolase", "refseq_ac": "NP_012298", "gene_names_uniprotkb": "DAL3", "gene_names_refseq": "DAL3", "protein_names_uniprotkb": "Ureidoglycolate lyase; 4.3.2.3; Degradation of allantoin protein 3; Ureidoglycolatase; Ureidoglycolate hydrolase", "protein_names_refseq": "ureidoglycolate hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR032C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1776360;24374639;3915539;5965980;9169870", "class_list": "", "function": "Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVW3", "ec_number_list": "4.3.2.3", "go_molecular_function": "GO:0004848 ureidoglycolate hydrolase activity;GO:0050385 ureidoglycolate lyase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0000256 allantoin catabolic process;GO:0006144 purine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32459-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32463-1", "uniprot_id": "ACPM_YEAST", "mass": 13943.0, "length": 125, "protein_name": "Acyl carrier protein, mitochondrial", "gene_name": "ACP1", "organism": "Yeast", "refseq_name": "acyl carrier protein", "refseq_ac": "NP_012729", "gene_names_uniprotkb": "ACP1", "gene_names_refseq": "ACP1", "protein_names_uniprotkb": "Acyl carrier protein, mitochondrial; ACP; NADH-ubiquinone oxidoreductase 9.6 kDa subunit", "protein_names_refseq": "acyl carrier protein", "tax_id": 559292, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734)", "pathway": " (sce:YKL192C); (R-SCE-77289); (R-SCE-9857492)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14562106;17322287;24374639;33491328;8196765;8394042", "class_list": "", "function": "Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX08", "ec_number_list": "", "go_molecular_function": "GO:0000035 acyl binding;GO:0000036 acyl carrier activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0022904 respiratory electron transport chain;GO:0009107 lipoate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32477-1", "uniprot_id": "GSH1_YEAST", "mass": 78254.0, "length": 678, "protein_name": "Glutamate--cysteine ligase", "gene_name": "GSH1", "organism": "Yeast", "refseq_name": "glutamate--cysteine ligase", "refseq_ac": "NP_012434", "gene_names_uniprotkb": "GSH1; J0832", "gene_names_refseq": "GSH1", "protein_names_uniprotkb": "Glutamate--cysteine ligase; 6.3.2.2; GCS; Gamma-ECS; Gamma-glutamylcysteine synthetase", "protein_names_refseq": "glutamate--cysteine ligase", "tax_id": 559292, "disease": "congenital nonspherocytic hemolytic anemia 7 (Disease Ontology:DOID:0111681); cystic fibrosis (Disease Ontology:DOID:1485); liver cirrhosis (Disease Ontology:DOID:5082); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cataract (Disease Ontology:DOID:83); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (sce:YJL101C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;1687097;18407956;24374639;33481703;33491328;7483851;8100487;8641269", "class_list": "", "function": "Catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine (gamma-GC), the first and rate-limiting step in the production of glutathione (GSH)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW83", "ec_number_list": "6.3.2.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004357 glutamate-cysteine ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0042542 response to hydrogen peroxide;GO:0046686 response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32522-1", "uniprot_id": "PT309_YEAST", "mass": 112646.0, "length": 965, "protein_name": "Mitochondrial COX1 translation regulator PET309", "gene_name": "PET309", "organism": "Yeast", "refseq_name": "Pet309p", "refseq_ac": "NP_013168", "gene_names_uniprotkb": "PET309; L2189", "gene_names_refseq": "PET309", "protein_names_uniprotkb": "Mitochondrial COX1 translation regulator PET309", "protein_names_refseq": "Pet309p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR067C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;20489023;24374639;33491328;7664742;9169871;9692914", "class_list": "", "function": "Required for initiation of translation of the COX1 coding region. Also involved in the stability of the intron containing transcript of COX1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY68", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0006396 RNA processing;GO:0007005 mitochondrion organization;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0042780 tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32522-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32524-1", "uniprot_id": "PRP21_YEAST", "mass": 33052.0, "length": 280, "protein_name": "Pre-mRNA-splicing factor PRP21", "gene_name": "PRP21", "organism": "Yeast", "refseq_name": "Prp21p", "refseq_ac": "NP_012332", "gene_names_uniprotkb": "PRP21; J0322; SPP91", "gene_names_refseq": "PRP21; SPP91", "protein_names_uniprotkb": "Pre-mRNA-splicing factor PRP21", "protein_names_refseq": "Prp21p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL203W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11884590;14562106;1505518;17322287;18407956;19779198;21126336;23749301;24374639;32597660;33481703;33491328;7754713;8341697;8641269", "class_list": "", "function": "mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVZ1;Q6Q5G7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P32524-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32559-1", "uniprot_id": "MSS1_YEAST", "mass": 58352.0, "length": 526, "protein_name": "tRNA modification GTPase MSS1, mitochondrial", "gene_name": "MSS1", "organism": "Yeast", "refseq_name": "Mss1p", "refseq_ac": "NP_013736", "gene_names_uniprotkb": "MSS1; PET53; YM9711.13C", "gene_names_refseq": "MSS1; PET53", "protein_names_uniprotkb": "tRNA modification GTPase MSS1, mitochondrial", "protein_names_refseq": "Mss1p", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 23 (Disease Ontology:DOID:0111500); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YMR023C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;15509579;24374639;8392589;9169872;9774408", "class_list": "", "function": "GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Involved in the expression of cytochrome c oxidase subunit 1 (COX1). Works in association with the small subunit of mitoribosomes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ7;Q0PHA7", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0070899 mitochondrial tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32559-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32590-1", "uniprot_id": "HSP79_YEAST", "mass": 77621.0, "length": 693, "protein_name": "Heat shock protein homolog SSE2", "gene_name": "SSE2", "organism": "Yeast", "refseq_name": "adenyl-nucleotide exchange factor SSE2", "refseq_ac": "NP_009728", "gene_names_uniprotkb": "SSE2; HSP; YBR1221", "gene_names_refseq": "SSE2", "protein_names_uniprotkb": "Heat shock protein homolog SSE2", "protein_names_refseq": "adenyl-nucleotide exchange factor SSE2", "tax_id": 559292, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); Chagas disease (Disease Ontology:DOID:12140); Parkinson's disease (Disease Ontology:DOID:14330); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); liver benign neoplasm (Disease Ontology:DOID:916); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YBR169C); (R-SCE-3371453)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;15665377;17322287;17330950;18407956;19684113;19795423;19823750;20702584;21126336;23749301;24374639;33481703;33491328;7813418;8257794;8406043", "class_list": "", "function": "Has a calcium-dependent calmodulin-binding activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQG5", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006457 protein folding;GO:0042026 protein refolding;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32601-1", "uniprot_id": "MSS4_YEAST", "mass": 16126.0, "length": 143, "protein_name": "Protein DSS4", "gene_name": "DSS4", "organism": "Yeast", "refseq_name": "guanine nucleotide exchange factor DSS4", "refseq_ac": "NP_015342", "gene_names_uniprotkb": "DSS4; LPZ16C; YP9531.11C", "gene_names_refseq": "DSS4", "protein_names_uniprotkb": "Protein DSS4", "protein_names_refseq": "guanine nucleotide exchange factor DSS4", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR017C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;24374639;8429886;9169875", "class_list": "", "function": "Guanine-nucleotide-releasing protein that acts on SEC4. Might play a general role in vesicular transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W427;Q12299;Q3S1N1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P32601-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32611-1", "uniprot_id": "RML2_YEAST", "mass": 43786.0, "length": 393, "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "RML2", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL2m RML2", "refseq_ac": "NP_010864", "gene_names_uniprotkb": "RML2; SYGP-ORF37", "gene_names_refseq": "RML2; uL2m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2m; 54S ribosomal protein RML2, mitochondrial; L2", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL2m RML2", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL050C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10320805;11529680;14562106;24374639;24675956;25609543;9079633;9169868", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLK0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0016740 transferase activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32613-1", "uniprot_id": "TCA17_YEAST", "mass": 17354.0, "length": 152, "protein_name": "TRAPP-associated protein TCA17", "gene_name": "TCA17", "organism": "Yeast", "refseq_name": "Tca17p", "refseq_ac": "NP_010866", "gene_names_uniprotkb": "TCA17; SYGP-ORF36", "gene_names_refseq": "TCA17", "protein_names_uniprotkb": "TRAPP-associated protein TCA17; 17 kDa TRAPP complex-associated protein", "protein_names_refseq": "Tca17p", "tax_id": 559292, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); rhabdomyolysis-myalgia syndrome (Disease Ontology:DOID:0080992)", "pathway": " (sce:YEL048C); (R-SCE-204005); (R-SCE-8876198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14562106;17322287;19220810;19416478;24374639;9169868", "class_list": "", "function": "Required, together with the TRAPP II subunit TRS33, for TRAPP II complex assembly or stability, and for proper Golgi localization of TRAPP and the Rab GTPase YPT31., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLK2;Q6Q561", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0065003 protein-containing complex assembly;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32613-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32617-1", "uniprot_id": "IES6_YEAST", "mass": 18533.0, "length": 166, "protein_name": "Chromatin-remodeling complex subunit IES6", "gene_name": "IES6", "organism": "Yeast", "refseq_name": "Ies6p", "refseq_ac": "NP_010870", "gene_names_uniprotkb": "IES6; SYGP-ORF13", "gene_names_refseq": "IES6", "protein_names_uniprotkb": "Chromatin-remodeling complex subunit IES6; Ino eighty subunit 6", "protein_names_refseq": "Ies6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL044W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12887900;14562095;14562106;15184655;15607974;17322287;17562861;23749301;24374639;32597660;33481703;33491328;9169868", "class_list": "", "function": "Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Also involved in the regulation of telomere length., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLK5;Q6Q5Q5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031011 Ino80 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32617-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32656-1", "uniprot_id": "CHAC_YEAST", "mass": 26294.0, "length": 232, "protein_name": "Glutathione-specific gamma-glutamylcyclotransferase", "gene_name": "GCG1", "organism": "Yeast", "refseq_name": "gamma-glutamylcyclotransferase", "refseq_ac": "NP_011090", "gene_names_uniprotkb": "GCG1; SYGP-ORF3", "gene_names_refseq": "GCG1", "protein_names_uniprotkb": "Glutathione-specific gamma-glutamylcyclotransferase; 4.3.2.7; Gamma-GCG", "protein_names_refseq": "gamma-glutamylcyclotransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER163C); (R-SCE-174403)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562095;14562106;17322287;23070364;24374639;27913623;9169868", "class_list": "", "function": "Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase DUG1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM71", "ec_number_list": "4.3.2.7", "go_molecular_function": "GO:0003839 gamma-glutamylcyclotransferase activity;GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006751 glutathione catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32767-1", "uniprot_id": "KA122_YEAST", "mass": 123531.0, "length": 1081, "protein_name": "Importin beta-like protein KAP122", "gene_name": "KAP122", "organism": "Yeast", "refseq_name": "Kap122p", "refseq_ac": "NP_011499", "gene_names_uniprotkb": "KAP122; PDR6", "gene_names_refseq": "KAP122; PDR6", "protein_names_uniprotkb": "Importin beta-like protein KAP122; Karyopherin-122; Pleiotropic drug resistance regulatory protein 6", "protein_names_refseq": "Kap122p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL016W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10525531;10617640;10684247;14562106;16432237;1882553;18838542;24374639;9169869", "class_list": "", "function": "Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUC1", "ec_number_list": "", "go_molecular_function": "GO:0005049 nuclear export signal receptor activity;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0051168 nuclear export;GO:0006606 protein import into nucleus;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32767-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32785-1", "uniprot_id": "FMT_YEAST", "mass": 44617.0, "length": 401, "protein_name": "Methionyl-tRNA formyltransferase, mitochondrial", "gene_name": "FMT1", "organism": "Yeast", "refseq_name": "methionyl-tRNA formyltransferase", "refseq_ac": "NP_009540", "gene_names_uniprotkb": "FMT1; YBL0311; YBL0313", "gene_names_refseq": "FMT1", "protein_names_uniprotkb": "Methionyl-tRNA formyltransferase, mitochondrial; 2.1.2.9; MtFMT", "protein_names_refseq": "methionyl-tRNA formyltransferase", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 15 (Disease Ontology:DOID:0111491); nuclear type mitochondrial complex I deficiency 27 (Disease Ontology:DOID:0112090)", "pathway": " (sce:YBL013W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10781559;12549912;1332308;14562095;14562106;14576278;24374639;30409808;33491328;7813418", "class_list": "", "function": "Formylates methionyl-tRNA in mitochondria and the cytoplasm (PubMed:10781559, PubMed:30409808). Responsible for the formylation of the 8 N-terminally formylated (Nt-formylated) mitochondrial matrix proteins that are encoded by mitochondrial DNA (PubMed:10781559, PubMed:12549912). Nt-formylated proteins in the cytoplasm are strongly up-regulated in stationary phase or upon starvation for specific amino acids (His or Lys) and are targeted for degradation by a PSH1 E3 ubiquitin ligase-mediated fMet/N-end rule pathway. Increased Nt-formylation of cytosolic proteins appears to be important for adaptation to these stresses. Stationary phase-degraded Nt-formylated proteins include histone H3-like centromeric protein CSE4, Mediator complex subunit 3 (PGD1) and small ribosomal subunit protein uS8-A (RPS22A) (PubMed:30409808)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY7;Q6RUA6", "ec_number_list": "2.1.2.9", "go_molecular_function": "GO:0004479 methionyl-tRNA formyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32787-1", "uniprot_id": "MG101_YEAST", "mass": 30091.0, "length": 269, "protein_name": "Mitochondrial genome maintenance protein MGM101", "gene_name": "MGM101", "organism": "Yeast", "refseq_name": "Mgm101p", "refseq_ac": "NP_012678", "gene_names_uniprotkb": "MGM101; J2181; MGM9", "gene_names_refseq": "MGM101; MGM9", "protein_names_uniprotkb": "Mitochondrial genome maintenance protein MGM101", "protein_names_refseq": "Mgm101p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR144W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10209025;14576278;21126336;22814378;24374639;30516470;32597660;33491328;8346025;8641269", "class_list": "", "function": "Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWW3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0000262 mitochondrial chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0036297 interstrand cross-link repair;GO:0000725 recombinational repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32805-1", "uniprot_id": "FZF1_YEAST", "mass": 33994.0, "length": 299, "protein_name": "Zinc finger protein FZF1", "gene_name": "FZF1", "organism": "Yeast", "refseq_name": "Fzf1p", "refseq_ac": "NP_011260", "gene_names_uniprotkb": "FZF1; NCR299; SUL1", "gene_names_refseq": "FZF1; NRC299; RSU1; SUL1", "protein_names_uniprotkb": "Zinc finger protein FZF1; Sulfite resistance protein 1", "protein_names_refseq": "Fzf1p", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (sce:YGL254W); (R-SCE-76061)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;16879422;24374639;33491328;7992510;8322518;8972578;9169869", "class_list": "", "function": "May function as a transcription factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV81;Q2VQB9;Q2VQC2;Q2VQC3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0018890 cyanamide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32831-1", "uniprot_id": "NGR1_YEAST", "mass": 75024.0, "length": 672, "protein_name": "Negative growth regulatory protein NGR1", "gene_name": "NGR1", "organism": "Yeast", "refseq_name": "Ngr1p", "refseq_ac": "NP_009771", "gene_names_uniprotkb": "NGR1; RBP1; YBR1459", "gene_names_refseq": "NGR1; RBP1", "protein_names_uniprotkb": "Negative growth regulatory protein NGR1; RNA-binding protein RBP1", "protein_names_refseq": "Ngr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR212W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;15665377;17563356;18407956;19684113;19779198;20702584;21177495;22814378;23749301;24374639;32597660;33229814;33481703;33491328;7813418;8325883", "class_list": "", "function": "May be an RNA-binding protein involved in control of an RNA processing pathway that influences the regulation of cell growth in early log phase. Can bind to RNA and single-stranded DNA but not double-stranded DNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VQK8", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32831-1", "record_type": "protein" } ]